GenomeNet

Database: Pfam
Entry: Pico_P2A
LinkDB: Pico_P2A
Original site: Pico_P2A 
#=GF ID   Pico_P2A
#=GF AC   PF00947.21
#=GF DE   Picornavirus core protein 2A
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_138 (release 3.0)
#=GF GA   21.00 15.00;
#=GF TC   21.00 15.30;
#=GF NC   20.70 14.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0124
#=GF RN   [1]
#=GF RM   10523291
#=GF RT   The structure of the 2A proteinase from a common cold virus: a
#=GF RT   proteinase responsible for the shut-off of host-cell protein
#=GF RT   synthesis. 
#=GF RA   Petersen JF, Cherney MM, Liebig HD, Skern T, Kuechler E, James
#=GF RA   MN; 
#=GF RL   EMBO J 1999;18:5463-5475.
#=GF DR   INTERPRO; IPR000081;
#=GF DR   MEROPS; C3;
#=GF DR   SCOP; 2hrv; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This protein is a protease, involved in cleavage of the
#=GF CC   polyprotein.
#=GF SQ   8
#=GS A0A0V1KJU5_9BILA/1-92      AC A0A0V1KJU5.1
#=GS POLG_POL1M/899-1025        AC P03300.3
#=GS A0A0B5GG60_9PICO/937-1064  AC A0A0B5GG60.1
#=GS A0A0V1KI70_9BILA/1-69      AC A0A0V1KI70.1
#=GS POLG_HRV8A/882-1007        AC P07210.3
#=GS A0A0V0T2H0_9BILA/37-163    AC A0A0V0T2H0.1
#=GS A0A0V1GMQ2_9BILA/254-296   AC A0A0V1GMQ2.1
#=GS A0A0V0T4S7_9BILA/881-996   AC A0A0V0T4S7.1
A0A0V1KJU5_9BILA/1-92                 .........................-------NDWANLVWEDSSRDLLVSSTTAQGCDTIARCDCQTGVY.YCNSKRKHYPVSFSKPSLIYVE....ASEYYPAR......YQSHLMLAAGHSEPGDCGGIF-------------------------------llw....................
POLG_POL1M/899-1025                   .........................NYHLATQDDLQNAVNVMWSRDLLVTESRAQGTDSIARCNCNAGVY.YCESRRKYYPVSFVGPTFQYME....ANNYYPAR......YQSHMLIGHGFASPGDCGGILRCHHGVIGIITAGGEGLVAFSDIRDLYAYEE.......................
A0A0B5GG60_9PICO/937-1064             .................yhwvladw------HNNQRELVWADSDRDVVCFKHKTTHQPK--LCTCKRGY-.WT-ANMCMFNTTKRARFSTWVEgfevESETRGDH......IQLDAIQISKPIPEGWCGSPLFCEHGIVGMATASTDSSSFFTHIASM-----pfvk...................
A0A0V1KI70_9BILA/1-69                 ........................m---------------------------------------------.-----RKHYPVSFSKPSLIFVE....ASEYYPAR......YQSHLMLAVGHSEPGDCGGILRCQHGVVGIVSTGGNGLVGFAD---------.......................
POLG_HRV8A/882-1007                   .........................NLHLFN-SDLDDSILVSYSSDLIIYRTNTEGNDVIPNCDCTECTY.YCHHKDRYFPIRVTAHDWYEIQ....ESEYYPKH......IQYNLLIGEGPCEPGDCGGKLLCKHGVIGMITAGGEGHVAFIDLRKFQCAEE.......................
A0A0V0T2H0_9BILA/37-163               .........................NRHLATHNDWANLVWEDSSRDLLVSSTTAQGCDTIARCDCQTGVY.YCNSKRKHYPVSFSKPSLIYVE....ASEYYPAR......YQSHLMLAAGHSEPGDCGGILRCQHGVVGIVSTGGNGLVGFADVRDLLWLDE.......................
A0A0V1GMQ2_9BILA/254-296              .........................NRHLATHNDWANLVWEDSSRDLLVSSTTAQGCDTIARCNCQTG--.----------------------....--------......----------------------------------------------------.......................
A0A0V0T4S7_9BILA/881-996              .........................NRHLATHNDWANLVWEDSSRDLLVSSTTAQGCDTIARCNCQTGVY.YCNSMRKHYPVSFSKPSLIFVE....ASEYYPAR......YQSHLMLAVGHSEPGDCA----------------------------------meqgvsdyikglgdafgmgftda
#=GC seq_cons                         .........................NhHLhspNDhsNLVWtDSSRDLLVopTsAQGsDoIARCsCpsGsY.YCpupRKaYPVSFotPohhaVE....ASEYYPAR......YQSHLhlusGauEPGDCGGhLhCpHGllGhhosuspu.shF.c................................
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