#=GF ID Pro_sub2
#=GF AC PF18513.5
#=GF DE Prodomain subtilisin 2
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF03531
#=GF GA 25.00 25.00;
#=GF TC 40.00 119.10;
#=GF NC 23.10 20.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0570
#=GF RN [1]
#=GF RM 23011838
#=GF RT Solution NMR structure of a sheddase inhibitor prodomain from
#=GF RT the malarial parasite Plasmodium falciparum.
#=GF RA He Y, Chen Y, Oganesyan N, Ruan B, O'Brochta D, Bryan PN, Orban
#=GF RA J;
#=GF RL Proteins. 2012;80:2810-2817.
#=GF DR INTERPRO; IPR040935;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Plasmodium subtilisin 2 (Sub2) is a multidomain protein that
#=GF CC plays an important role in malaria infection. This domain is a
#=GF CC conserved region of the inhibitory prodomain of Sub2 from
#=GF CC Plasmodium falciparum, termed prosub2 which has structural
#=GF CC similarity to bacterial and mammalian subtilisin-like
#=GF CC prodomains.
#=GF SQ 23
#=GS Q7RQ80_PLAYO/496-583 AC Q7RQ80.1
#=GS W7JL77_PLAFA/539-626 AC W7JL77.1
#=GS A0A1D3TIE8_9APIC/560-647 AC A0A1D3TIE8.1
#=GS A0A1D3PCK4_PLAMA/634-721 AC A0A1D3PCK4.1
#=GS A5K529_PLAVS/647-734 AC A5K529.1
#=GS K6UTL2_PLACD/495-582 AC K6UTL2.1
#=GS A0A0L1I767_PLAFA/552-639 AC A0A0L1I767.1
#=GS A0A1Y1JF50_PLAGO/667-754 AC A0A1Y1JF50.1
#=GS A0A0L7M1E8_PLAF4/550-637 AC A0A0L7M1E8.1
#=GS B3L5H8_PLAKH/623-710 AC B3L5H8.1
#=GS W4ISJ2_PLAFP/536-623 AC W4ISJ2.1
#=GS SUB2_PLAF7/553-640 AC Q8IHZ5.1
#=GS A0A0L7KF05_PLAFX/536-623 AC A0A0L7KF05.1
#=GS A0A024VNL3_PLAFA/544-631 AC A0A024VNL3.1
#=GS W7K4R7_PLAFO/553-640 AC W7K4R7.1
#=GS A0A024X5F3_PLAFC/536-623 AC A0A024X5F3.1
#=GS A0A0L0CXI4_PLAFA/555-642 AC A0A0L0CXI4.1
#=GS A0A1A8VTN9_9APIC/563-650 AC A0A1A8VTN9.1
#=GS A0A509AID5_PLABA/501-588 AC A0A509AID5.1
#=GS A0A024WMS6_PLAFA/537-624 AC A0A024WMS6.1
#=GS A0A024W5U5_PLAFA/536-623 AC A0A024W5U5.1
#=GS A0A1J1H6F1_PLARL/356-443 AC A0A1J1H6F1.1
#=GS A0A1A8YW34_9APIC/561-648 AC A0A1A8YW34.1
Q7RQ80_PLAYO/496-583 ..KEQELIFIFHGDLDLHSKKMKTIINEANVKFTKYINMHFKDVKNIRYDISSPINFVCFFIPIIFDMSNLKILKEALIILHNELKNYID
W7JL77_PLAFA/539-626 .s-KQELILVLKGELDLHSKNMKNVINNAKKNLEKYFKEHFKEFDKISYDISTPINFLCIFIPTLFDMNNMDLLKQALLILHNDLHEYVE
A0A1D3TIE8_9APIC/560-647 .s-QQELIFVLRGDLDLHSPFMRKVIRRGNAKFEKYIKKHFKEVEKISYDVSSPINFLCFFVPTVFNMNNFNLLKEALEILFNELKRYTE
A0A1D3PCK4_PLAMA/634-721 .s-NQELIFVLRGDLDLHSPFMKNVIKNANNKFETYIKKNFEEVDKISYDVSSPINFLCFFVPNVFDMNNYHILKEALTILYKELEEYTE
A5K529_PLAVS/647-734 .e-RQELIFVLRGDLDLHSTYMRRVIKRSNAKFEEHIKKNFQQVDSIVYDVSSPINFLCFFVPTVFDMSNFHMLKEALLVLQKELERYME
K6UTL2_PLACD/495-582 ..DKQELIFVLRGDLDLHSAYMKRVIKRSNAKFEQHIKKNFQQVDRIVYDVSSPINFLCFFVPTVFDMSNFHLLKEALLVLQRELERYME
A0A0L1I767_PLAFA/552-639 .s-KQELILVLKGELDLHSKNMKNVINNAKKNLEKYFKEHFKEFDKISYDISTPINFLCIFIPTVFDMNNMDLLKQALLILHNDLHEYVE
A0A1Y1JF50_PLAGO/667-754 .s-KQELIFVLRGDLDLNSTHMRNVIKRGKSKFENQIKKHFEQVDKILYDVSSPINFLCFFVPNVFNMSNFHLLKEALIVLHRELEEYTE
A0A0L7M1E8_PLAF4/550-637 .s-KQELILVLKGELDLHSKNMKNVINNAKKNLEKYFKEHFKEFDKISYDISTPINFLCIFIPTVFDMNNMDLLKQALLILHNDLHEYVE
B3L5H8_PLAKH/623-710 ..DKQELILVLRGDLDLHSPYMKLVIKRSNAKFEQHIKRNFEQIDKIVYDISSPINFLCFFVPTIFDMNNFHLLKEALMVLHKELERYME
W4ISJ2_PLAFP/536-623 .s-KQELILVLKGELDLHSKNMKNVINNAKKNLEKYFKEHFKEFDKISYDISTPINFLCIFIPTVFDMNNMDLLKQALLILHNDLHEYVE
SUB2_PLAF7/553-640 .s-KQELILVLKGELDLHSKNMKNVINNAKKNLEKYFKEHFKEFDKISYDISTPINFLCIFIPTLFDMNNMDLLKQALLILHNDLHEYVE
A0A0L7KF05_PLAFX/536-623 .s-KQELILVLKGELDLHSKNMKNVINNAKKNLEKYFKEHFKEFDKISYDISTPINFLCIFIPTLFDMNNMDLLKQALLILHNDLHEYVE
A0A024VNL3_PLAFA/544-631 .s-KQELILVLKGELDLHSKNMKNVINNAKKNLEKYFKEHFKEFDKISYDISTPINFLCIFIPTLFDMNNMDLLKQALLILHNDLHEYVE
W7K4R7_PLAFO/553-640 .s-KQELILVLKGELDLHSKNMKNVINNAKKNLEKYFKEHFKEFDKISYDISTPINFLCIFIPTLFDMNNMDLLKQALLILHNDLHEYVE
A0A024X5F3_PLAFC/536-623 .s-KQELILVLKGELDLHSKNMKNVINNAKKNLEKYFKEHFKEFDKISYDISTPINFLCIFIPTVFDMNNMDLLKQALLILHNDLHEYVE
A0A0L0CXI4_PLAFA/555-642 .s-KQELILVLKGELDLHSKNMKNVINNAKKNLEKYFKEHFKEFDKISYDISTPINFLCIFIPTVFDMNNMDLLKQALLILHNDLHEYVE
A0A1A8VTN9_9APIC/563-650 .s-QQELIFVLRGDLDLHSPFMRKVIRRGNAKFEKYIKKHFKEVEKISYDVSSPINFLCFFVPTVFNMNNFNLLKEALEILFNELKRYTE
A0A509AID5_PLABA/501-588 ..KEQELIFIFHGNLDLHSKEMKTVINEANAKFTKYINMHFKDVKNIRYDISSPINFVCFFIPIIFDMSNLKILKEALIILNNELKDYID
A0A024WMS6_PLAFA/537-624 .s-KQELILVLKGELDLHSKNMKNVINNAKKNLEKYFKEHFKEFDKISYDISTPINFLCIFIPTLFDMNNMDLLKQALLILHNDLHEYVE
A0A024W5U5_PLAFA/536-623 .s-KQELILVLKGELDLHSKNMKNVINNAKKNLEKYFKEHFKEFDKISYDISTPINFLCIFIPTVFDMNNMDLLKQALLILHNDLHEYVE
A0A1J1H6F1_PLARL/356-443 sw--QELILVLRGELDLHSSHMKNLIVETKNKLESYIKKNFNQVDKISYDVSSPINFICFFFPNVFNMDNLSLLKEALTIIYDELKDYTE
A0A1A8YW34_9APIC/561-648 .s-QQELIFVLRGDLDLHSPYMRKVIRRGNAKFEKYIKKHFKEVEKISYDISSPINFLCFFVPNVFNMNNFNLLKEALEILFNELKKYTE
#=GC seq_cons .S.KQELILVL+G-LDLHSKpMKNVINpAKpphEKYhKcHFKEhDKISYDISoPINFLChFIPTVFDMNNhcLLKpALLILHN-L+EYlE
//
