GenomeNet

Database: Pfam
Entry: RANK_CRD_2
LinkDB: RANK_CRD_2
Original site: RANK_CRD_2 
#=GF ID   RANK_CRD_2
#=GF AC   PF18278.2
#=GF DE   Receptor activator of the NF-KB cysteine-rich repeat domain 2
#=GF AU   Smart A;0000-0002-6965-5633
#=GF SE   ECOD:EUF04727
#=GF GA   26.80 26.80;
#=GF TC   27.00 29.70;
#=GF NC   25.80 24.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   20483727
#=GF RT   Structural and functional insights of RANKL-RANK interaction and
#=GF RT   signaling.
#=GF RA   Liu C, Walter TS, Huang P, Zhang S, Zhu X, Wu Y, Wedderburn LR,
#=GF RA   Tang P, Owens RJ, Stuart DI, Ren J, Gao B;
#=GF RL   J Immunol. 2010;184:6910-6919.
#=GF DR   INTERPRO; IPR041648;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found in the receptor activator of the NF-KB
#=GF CC   (RANK) present in Mus musculus. RANK and its cognate ligand
#=GF CC   RANKL play a role in bone remodelling, immune function and
#=GF CC   mammary gland development in conjunction with various cytokines
#=GF CC   and hormones. The binding of RANKL to RANK causes trimerisation
#=GF CC   of the receptor, which activates the signalling pathway and
#=GF CC   results in osteoclastogenesis from progenitor cells and the
#=GF CC   activation of mature osteoclasts receptor activator of the
#=GF CC   NF-KB. This domain is the second of four cysteine rich
#=GF CC   pseudo-repeat domains (CRDs) and so is known as CRD2. RANK moves
#=GF CC   via a hinge region between CRD2 and CRD3 to make close contact
#=GF CC   with RANKL [1].
#=GF SQ   180
#=GS A0A091HXS8_CALAN/73-113     AC A0A091HXS8.1
#=GS A0A2K5VA56_MACFA/89-129     AC A0A2K5VA56.1
#=GS A0A2K5QXJ9_CEBCA/89-129     AC A0A2K5QXJ9.1
#=GS F1MTC1_BOVIN/67-107         AC F1MTC1.2
#=GS A0A4D9F393_9SAUR/84-124     AC A0A4D9F393.1
#=GS A0A0Q3TKJ5_AMAAE/1199-1239  AC A0A0Q3TKJ5.1
#=GS A0A2K5IES5_COLAP/75-115     AC A0A2K5IES5.1
#=GS A0A402FGA1_9SAUR/91-131     AC A0A402FGA1.1
#=GS A0A340XEY9_LIPVE/314-354    AC A0A340XEY9.1
#=GS A0A2I3GU77_NOMLE/90-130     AC A0A2I3GU77.1
#=GS L5KID8_PTEAL/73-113         AC L5KID8.1
#=GS A0A2K6PQ96_RHIRO/67-107     AC A0A2K6PQ96.1
#=GS A0A2K5IEQ3_COLAP/75-115     AC A0A2K5IEQ3.1
#=GS A0A2K5IET0_COLAP/75-115     AC A0A2K5IET0.1
#=GS A0A2K6F3K0_PROCO/89-129     AC A0A2K6F3K0.1
#=GS A0A3Q0DI02_TARSY/139-179    AC A0A3Q0DI02.1
#=GS F7DWK7_XENTR/41-81          AC F7DWK7.1
#=GS A0A091EYT5_CORBR/68-108     AC A0A091EYT5.1
#=GS A0A3Q7VJA6_URSAR/91-131     AC A0A3Q7VJA6.1
#=GS A0A2U3VS90_ODORO/248-288    AC A0A2U3VS90.1
#=GS A0A2I0MXD0_COLLI/93-133     AC A0A2I0MXD0.1
#=GS A0A2K5Z9B3_MANLE/64-104     AC A0A2K5Z9B3.1
#=GS A0A2K6PQ77_RHIRO/67-107     AC A0A2K6PQ77.1
#=GS A0A2K5Z993_MANLE/64-104     AC A0A2K5Z993.1
#=GS A0A2R8ZKH5_PANPA/87-127     AC A0A2R8ZKH5.1
#=GS A0A2K5EGC2_AOTNA/90-130     AC A0A2K5EGC2.1
#=GS A0A2K5IF08_COLAP/75-115     AC A0A2K5IF08.1
#=GS A0A2I3TJN8_PANTR/89-129     AC A0A2I3TJN8.1
#=GS H2NWH0_PONAB/89-129         AC H2NWH0.1
#=GS A0A091W9P8_OPIHO/68-108     AC A0A091W9P8.1
#=GS A0A2K6B115_MACNE/89-129     AC A0A2K6B115.1
#=GS L9L9E0_TUPCH/85-125         AC L9L9E0.1
#=GS A0A2R8ZLJ8_PANPA/64-104     AC A0A2R8ZLJ8.1
#=GS H2QEM5_PANTR/87-127         AC H2QEM5.2
#=GS A0A3M0KRZ5_HIRRU/69-109     AC A0A3M0KRZ5.1
#=GS A0A0A0AHX2_CHAVO/68-108     AC A0A0A0AHX2.1
#=GS A0A2K5VA70_MACFA/89-129     AC A0A2K5VA70.1
#=GS K7E0G0_MONDO/90-130         AC K7E0G0.1
#=GS J9NZL3_CANLF/90-130         AC J9NZL3.1
#=GS A0A2I3HA87_NOMLE/90-130     AC A0A2I3HA87.1
#=GS A0A2K6F3M2_PROCO/89-129     AC A0A2K6F3M2.1
#=GS G3STC0_LOXAF/68-108         AC G3STC0.1
#=GS A0A2K5M118_CERAT/89-129     AC A0A2K5M118.1
#=GS A0A091X755_NIPNI/68-108     AC A0A091X755.1
#=GS A0A2K5Z9A8_MANLE/64-104     AC A0A2K5Z9A8.1
#=GS A0A452S060_URSAM/91-131     AC A0A452S060.1
#=GS A0A2K5M0Z5_CERAT/89-129     AC A0A2K5M0Z5.1
#=GS A0A2K5IF03_COLAP/185-225    AC A0A2K5IF03.1
#=GS A0A2I3MHA7_PAPAN/89-129     AC A0A2I3MHA7.1
#=GS A0A093GUJ4_DRYPU/68-108     AC A0A093GUJ4.1
#=GS A0A218UPG2_9PASE/82-122     AC A0A218UPG2.1
#=GS A0A2R8ZRK4_PANPA/64-104     AC A0A2R8ZRK4.1
#=GS A0A2K6KC91_RHIBE/87-127     AC A0A2K6KC91.1
#=GS R0JSP9_ANAPL/52-92          AC R0JSP9.1
#=GS A0A2U4BI36_TURTR/89-129     AC A0A2U4BI36.1
#=GS A0A3Q7WNY7_URSAR/89-129     AC A0A3Q7WNY7.1
#=GS A0A2U4BHR3_TURTR/89-129     AC A0A2U4BHR3.1
#=GS A0A1D5R243_MACMU/89-129     AC A0A1D5R243.1
#=GS TNR11_HUMAN/89-129          AC Q9Y6Q6.1
#=GS I3N3G9_ICTTR/89-129         AC I3N3G9.2
#=GS A0A3L8SMD1_CHLGU/106-146    AC A0A3L8SMD1.1
#=GS H0YUW2_TAEGU/68-108         AC H0YUW2.1
#=GS A0A1L8FSE2_XENLA/90-130     AC A0A1L8FSE2.1
#=GS A0A2I2ZGI0_GORGO/89-129     AC A0A2I2ZGI0.1
#=GS G3HD51_CRIGR/1143-1183      AC G3HD51.1
#=GS A0A2K6B104_MACNE/89-129     AC A0A2K6B104.1
#=GS A0A2I3HHN1_NOMLE/87-127     AC A0A2I3HHN1.1
#=GS A0A0D9S014_CHLSB/34-74      AC A0A0D9S014.1
#=GS G3QNV1_GORGO/89-129         AC G3QNV1.2
#=GS A0A1W2PR41_HUMAN/89-129     AC A0A1W2PR41.1
#=GS M3X7G5_FELCA/89-129         AC M3X7G5.3
#=GS A0A2K6PQ82_RHIRO/67-107     AC A0A2K6PQ82.1
#=GS A0A226NJ44_CALSU/84-124     AC A0A226NJ44.1
#=GS A0A2I3ND23_PAPAN/89-129     AC A0A2I3ND23.1
#=GS A0A2I3SCA0_PANTR/89-129     AC A0A2I3SCA0.1
#=GS A0A1V4JWH1_PATFA/84-124     AC A0A1V4JWH1.1
#=GS A0A2K5Z955_MANLE/64-104     AC A0A2K5Z955.1
#=GS A0A2U3XK71_LEPWE/78-118     AC A0A2U3XK71.1
#=GS F7GWL8_CALJA/89-129         AC F7GWL8.2
#=GS A0A2R8PDN2_CALJA/89-129     AC A0A2R8PDN2.1
#=GS A0A1D5Q245_MACMU/34-74      AC A0A1D5Q245.1
#=GS A0A3Q7UUE8_URSAR/91-131     AC A0A3Q7UUE8.1
#=GS M7C7T0_CHEMY/65-105         AC M7C7T0.1
#=GS A0A2I3MC10_PAPAN/34-74      AC A0A2I3MC10.1
#=GS A0A2K5EGC5_AOTNA/34-74      AC A0A2K5EGC5.1
#=GS A0A1L1RVE1_CHICK/110-130    AC A0A1L1RVE1.2
#=GS A0A2I2ZUF9_GORGO/89-129     AC A0A2I2ZUF9.1
#=GS A0A2K6UHI9_SAIBB/85-125     AC A0A2K6UHI9.1
#=GS A0A2I2UQD4_FELCA/89-129     AC A0A2I2UQD4.2
#=GS A0A2R8ZKH6_PANPA/64-104     AC A0A2R8ZKH6.1
#=GS A0A2R8ZKH9_PANPA/64-104     AC A0A2R8ZKH9.1
#=GS F6WEI9_MACMU/89-129         AC F6WEI9.2
#=GS H9GV25_ANOCA/87-127         AC H9GV25.2
#=GS A0A2K5EG80_AOTNA/90-130     AC A0A2K5EG80.1
#=GS A0A2Y9P9Q0_DELLE/65-105     AC A0A2Y9P9Q0.1
#=GS A4IIS3_XENTR/90-130         AC A4IIS3.1
#=GS M3YYJ4_MUSPF/67-107         AC M3YYJ4.1
#=GS A0A1U7QXX5_MESAU/90-130     AC A0A1U7QXX5.1
#=GS A0A2K5M0Z9_CERAT/89-129     AC A0A2K5M0Z9.1
#=GS A0A2I3GWV7_NOMLE/87-127     AC A0A2I3GWV7.1
#=GS G1SNN2_RABIT/89-129         AC G1SNN2.1
#=GS U3KET4_FICAL/90-130         AC U3KET4.1
#=GS A0A2K5EG55_AOTNA/90-130     AC A0A2K5EG55.1
#=GS G1N029_MELGA/71-111         AC G1N029.1
#=GS A0A2I3M6J3_PAPAN/89-129     AC A0A2I3M6J3.1
#=GS A0A2K5M122_CERAT/89-129     AC A0A2K5M122.1
#=GS H0VSX1_CAVPO/94-134         AC H0VSX1.2
#=GS A0A091IX96_EGRGA/68-108     AC A0A091IX96.1
#=GS A0A093H7I1_STRCA/71-111     AC A0A093H7I1.1
#=GS A0A2K6KC87_RHIBE/87-127     AC A0A2K6KC87.1
#=GS A0A096N6C9_PAPAN/89-129     AC A0A096N6C9.1
#=GS A0A2K6F3J7_PROCO/89-129     AC A0A2K6F3J7.1
#=GS F7AS58_MONDO/90-130         AC F7AS58.2
#=GS A0A093SA83_9PASS/68-108     AC A0A093SA83.1
#=GS A0A493TPI5_ANAPP/84-124     AC A0A493TPI5.1
#=GS A0A2Y9KJH5_ENHLU/106-146    AC A0A2Y9KJH5.1
#=GS A0A2R8ZNB7_PANPA/34-74      AC A0A2R8ZNB7.1
#=GS A0A2K6PQ79_RHIRO/67-107     AC A0A2K6PQ79.1
#=GS A0A2K5QXK3_CEBCA/89-129     AC A0A2K5QXK3.1
#=GS A0A2K6F3N0_PROCO/89-129     AC A0A2K6F3N0.1
#=GS A0A2K5Z943_MANLE/64-104     AC A0A2K5Z943.1
#=GS A0A091FN17_9AVES/68-108     AC A0A091FN17.1
#=GS TNR11_MOUSE/90-130          AC O35305.1
#=GS TNR11_MOUSE/90-130          DR PDB; 4GIQ R; 60-100;
#=GS TNR11_MOUSE/90-130          DR PDB; 5BNQ R; 90-130;
#=GS TNR11_MOUSE/90-130          DR PDB; 3ME4 B; 90-130;
#=GS TNR11_MOUSE/90-130          DR PDB; 3ME4 A; 90-130;
#=GS TNR11_MOUSE/90-130          DR PDB; 3QBQ B; 90-130;
#=GS TNR11_MOUSE/90-130          DR PDB; 3QBQ D; 90-130;
#=GS TNR11_MOUSE/90-130          DR PDB; 3ME2 R; 90-130;
#=GS A0A2K6UHG5_SAIBB/98-138     AC A0A2K6UHG5.1
#=GS A0A452IZL2_9SAUR/84-124     AC A0A452IZL2.1
#=GS K7FKI7_PELSI/83-123         AC K7FKI7.1
#=GS G1Q5Y9_MYOLU/71-107         AC G1Q5Y9.1
#=GS A0A2K5VA50_MACFA/89-129     AC A0A2K5VA50.1
#=GS A0A2K6KC18_RHIBE/87-127     AC A0A2K6KC18.1
#=GS A0A3Q7S3R3_VULVU/68-108     AC A0A3Q7S3R3.1
#=GS K7GN73_PIG/89-129           AC K7GN73.9
#=GS E2QW81_CANLF/89-129         AC E2QW81.2
#=GS A0A2U4BHP5_TURTR/89-129     AC A0A2U4BHP5.1
#=GS A0A2R8P9K9_CALJA/89-129     AC A0A2R8P9K9.1
#=GS G1PUF6_MYOLU/71-107         AC G1PUF6.1
#=GS A0A1S3WCA8_ERIEU/146-186    AC A0A1S3WCA8.1
#=GS G1LI55_AILME/89-129         AC G1LI55.1
#=GS A0A2K5VA61_MACFA/89-129     AC A0A2K5VA61.1
#=GS A0A2K6UHM4_SAIBB/85-125     AC A0A2K6UHM4.1
#=GS A0A099YWB6_TINGU/68-108     AC A0A099YWB6.1
#=GS A0A151NFD7_ALLMI/84-124     AC A0A151NFD7.1
#=GS G1RBB3_NOMLE/87-127         AC G1RBB3.2
#=GS A0A2I3TEW2_PANTR/89-129     AC A0A2I3TEW2.1
#=GS A0A455AV43_PHYMC/129-169    AC A0A455AV43.1
#=GS G3SDV3_GORGO/89-129         AC G3SDV3.2
#=GS A0A2K5QXN0_CEBCA/89-129     AC A0A2K5QXN0.1
#=GS A0A3Q7WCS7_URSAR/34-74      AC A0A3Q7WCS7.1
#=GS I3LLE5_PIG/34-74            AC I3LLE5.2
#=GS A0A452G3M0_CAPHI/67-107     AC A0A452G3M0.1
#=GS A0A3Q0H8Q8_ALLSI/84-124     AC A0A3Q0H8Q8.1
#=GS A0A384AXH0_BALAS/151-191    AC A0A384AXH0.1
#=GS A0A2R8M405_CALJA/89-129     AC A0A2R8M405.1
#=GS A0A2K6PQ90_RHIRO/67-107     AC A0A2K6PQ90.1
#=GS A0A2K6B105_MACNE/89-129     AC A0A2K6B105.1
#=GS G5BCN5_HETGA/134-174        AC G5BCN5.1
#=GS A0A2R8P5V3_CALJA/89-129     AC A0A2R8P5V3.1
#=GS A0A1D5R192_MACMU/89-129     AC A0A1D5R192.1
#=GS A0A1D5QSR2_MACMU/89-129     AC A0A1D5QSR2.1
#=GS A0A2I3RGN8_PANTR/89-129     AC A0A2I3RGN8.1
#=GS A0A2K5M109_CERAT/89-129     AC A0A2K5M109.1
#=GS F7CYP7_HORSE/67-107         AC F7CYP7.2
#=GS A0A2K6B0Z6_MACNE/89-129     AC A0A2K6B0Z6.1
#=GS A0A226PX71_COLVI/84-124     AC A0A226PX71.1
#=GS A0A2I3NCT5_PAPAN/89-129     AC A0A2I3NCT5.1
#=GS A0A2K6F3K8_PROCO/89-129     AC A0A2K6F3K8.1
#=GS H0XJB2_OTOGA/90-130         AC H0XJB2.1
#=GS F7ENY4_ORNAN/69-109         AC F7ENY4.1
#=GS A0A2K5QXH5_CEBCA/89-129     AC A0A2K5QXH5.1
#=GS A0A1S3FE75_DIPOR/105-145    AC A0A1S3FE75.1
#=GS F1M8Z6_RAT/90-130           AC F1M8Z6.2
#=GS A0A1L8FXM9_XENLA/89-129     AC A0A1L8FXM9.1
#=GS A0A2K5VA52_MACFA/89-129     AC A0A2K5VA52.1
#=GS A0A2Y9FXT3_TRIMA/348-388    AC A0A2Y9FXT3.1
#=GS A0A1L1RT12_CHICK/84-104     AC A0A1L1RT12.2
#=GS A0A2K6B110_MACNE/89-129     AC A0A2K6B110.1
#=GS A0A2R8ZNB3_PANPA/64-104     AC A0A2R8ZNB3.1
#=GS A0A087R1Z5_APTFO/68-108     AC A0A087R1Z5.1
#=GS A0A2K5QXI5_CEBCA/89-129     AC A0A2K5QXI5.1
#=GS A0A2I3RWV8_PANTR/89-129     AC A0A2I3RWV8.1
#=GS A0A2K5M140_CERAT/34-74      AC A0A2K5M140.1
A0A091HXS8_CALAN/73-113                ..HKICDQGKALREVNPGNSTFQRQCACTMGYHWNEDCDCCQR...
A0A2K5VA56_MACFA/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2K5QXJ9_CEBCA/89-129                ..HKVCDTGKALVAVDIGNSTAPRRCTCTSGYHWSQDCECCRR...
F1MTC1_BOVIN/67-107                    ..HKVCDPGKALRAVEPGNRTAPRRCACTAGYHWSEDCRCCTR...
A0A4D9F393_9SAUR/84-124                ..HKICDEGRGLIEVNPGNRSYQRQCACTLGYHCNEDCDYCLR...
A0A0Q3TKJ5_AMAAE/1199-1239             ..HKICDQGKALREVNPGNSTFQRQCACTVGYHWNEDCDCCQR...
A0A2K5IES5_COLAP/75-115                ..HKVCDTGKALVAVDAGNSTAPRRCACMAGYHWSQDCECCRR...
A0A402FGA1_9SAUR/91-131                ..HKICDHGKALIEVHPGNSTSHRLCACMAGYHWNEDCDCCRR...
A0A340XEY9_LIPVE/314-354               ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSEDCRCCRR...
A0A2I3GU77_NOMLE/90-130                ..HKVCDTGKALVAVDPGNSTTPRRCACTAGYHWSQDCECCRR...
L5KID8_PTEAL/73-113                    ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSEDCDCCRR...
A0A2K6PQ96_RHIRO/67-107                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2K5IEQ3_COLAP/75-115                ..HKVCDTGKALVAVDAGNSTAPRRCACMAGYHWSQDCECCRR...
A0A2K5IET0_COLAP/75-115                ..HKVCDTGKALVAVDAGNSTAPRRCACMAGYHWSQDCECCRR...
A0A2K6F3K0_PROCO/89-129                ..HKVCDTGKALVAVDPGNRTAPRRCACTAGYHWSQDCECCRR...
A0A3Q0DI02_TARSY/139-179               ..HKVCDIGKALVAADAGNRTVPRRCACMAGYHWSQDCECCRR...
F7DWK7_XENTR/41-81                     ..HHICDSGKALKVAFRGNSTSPRKCVCEKGYHFSQDYEFCN-e..
A0A091EYT5_CORBR/68-108                ..HKICDQGKALKEVNPGNSTFQRQCACTMGYHWNEDCDCCQR...
A0A3Q7VJA6_URSAR/91-131                ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSADCDCCRR...
A0A2U3VS90_ODORO/248-288               ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSADCDCCRR...
A0A2I0MXD0_COLLI/93-133                ..HKICDQGKALREVNPGNSTFQRQCACTTGYHWDEDCDCCQR...
A0A2K5Z9B3_MANLE/64-104                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2K6PQ77_RHIRO/67-107                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2K5Z993_MANLE/64-104                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2R8ZKH5_PANPA/87-127                ..HKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRR...
A0A2K5EGC2_AOTNA/90-130                ..HKVCDTGKALVAVDIGNSTAPRRCTCTAGYHWSQDCECCRR...
A0A2K5IF08_COLAP/75-115                ..HKVCDTGKALVAVDAGNSTAPRRCACMAGYHWSQDCECCRR...
A0A2I3TJN8_PANTR/89-129                ..HKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRR...
H2NWH0_PONAB/89-129                    ..HKVCDTGKALVAVDAGNSTTPRRCACTAGYHWSQDCECCRR...
A0A091W9P8_OPIHO/68-108                ..HKICDQGKALREVNPGNSTFQRQCACTMGYHWNDDCDCCQR...
A0A2K6B115_MACNE/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
L9L9E0_TUPCH/85-125                    ..HKVCDTGKALVAVEPGNRTAPRRCACTTGYHWSQDCGCCRR...
A0A2R8ZLJ8_PANPA/64-104                ..HKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRR...
H2QEM5_PANTR/87-127                    ..HKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRR...
A0A3M0KRZ5_HIRRU/69-109                ..HKICDQGKALREVNPGNSTFQRQCACTMGYHWNEDCDCCQR...
A0A0A0AHX2_CHAVO/68-108                ..HKICDQGKALREVNPGNSTFQRQCACTMGYHWNEDCDCCQR...
A0A2K5VA70_MACFA/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
K7E0G0_MONDO/90-130                    ..HKVCDSGKGLTVVHPGNQTFPRQCACIPGYHWNGDSESCQR...
J9NZL3_CANLF/90-130                    ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSADCDCCRR...
A0A2I3HA87_NOMLE/90-130                ..HKVCDTGKALVAVDPGNSTTPRRCACTAGYHWSQDCECCRR...
A0A2K6F3M2_PROCO/89-129                ..HKVCDTGKALVAVDPGNRTAPRRCACTAGYHWSQDCECCRR...
G3STC0_LOXAF/68-108                    ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSDDCACCRR...
A0A2K5M118_CERAT/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A091X755_NIPNI/68-108                ..HKICDQGKALREVSPGNSTFQRQCACTMGYHWNEDCDCCQR...
A0A2K5Z9A8_MANLE/64-104                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A452S060_URSAM/91-131                ..HKVCDTGKALVAVEPGNRTAPRRCACTTGYHWSADCDCCRR...
A0A2K5M0Z5_CERAT/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2K5IF03_COLAP/185-225               ..HKVCDTGKALVAVDAGNSTAPRRCACMAGYHWSQDCECCRR...
A0A2I3MHA7_PAPAN/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A093GUJ4_DRYPU/68-108                ..HKICDQGKALKEVAPGNSTSQRRCACTVGYHWSEDCDCCQR...
A0A218UPG2_9PASE/82-122                ..HKICDQGKALREVNPGNSTFQRQCACTMGYHWNEDCDCCQR...
A0A2R8ZRK4_PANPA/64-104                ..HKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRR...
A0A2K6KC91_RHIBE/87-127                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
R0JSP9_ANAPL/52-92                     ..HKICDQGKALKEVNPGNSTFQRQCACTTGYHWNEDCDCCQR...
A0A2U4BI36_TURTR/89-129                ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSEDCRCCRR...
A0A3Q7WNY7_URSAR/89-129                ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSADCDCCRR...
A0A2U4BHR3_TURTR/89-129                ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSEDCRCCRR...
A0A1D5R243_MACMU/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
TNR11_HUMAN/89-129                     ..HKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRR...
I3N3G9_ICTTR/89-129                    ..HKVCDTGKALVAVDPGNRTAPRRCACTAGYHWSQDCECCRR...
A0A3L8SMD1_CHLGU/106-146               ..HKICDQGKALREVNPGNSTFQRQCACTMGYHWNEDCDCCQR...
H0YUW2_TAEGU/68-108                    ..HKICDQGKALREVNPGNSTFQRQCACTMGYHWNEDCDCCQR...
A0A1L8FSE2_XENLA/90-130                ..HQICDSGKALKVAFNGNRTSPRKCICEEGYHFSDDYEFCN-k..
A0A2I2ZGI0_GORGO/89-129                ..HKVCDTGKALVAVDAGNSTTPRRCACTAGYHWSQDCECCRR...
G3HD51_CRIGR/1143-1183                 ..HKVCDAGKALVAVDPGNHTAPRRCACTAGYHWNPDCECCRR...
A0A2K6B104_MACNE/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2I3HHN1_NOMLE/87-127                ..HKVCDTGKALVAVDPGNSTTPRRCACTAGYHWSQDCECCRR...
A0A0D9S014_CHLSB/34-74                 ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
G3QNV1_GORGO/89-129                    ..HKVCDTGKALVAVDAGNSTTPRRCACTAGYHWSQDCECCRR...
A0A1W2PR41_HUMAN/89-129                ..HKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRR...
M3X7G5_FELCA/89-129                    ..HKVCDSGKALVAVEPGNRTAPRRCACTAGYHWSADCDCCRR...
A0A2K6PQ82_RHIRO/67-107                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A226NJ44_CALSU/84-124                ..HKICDQGKALREVNPGNSTFQRQCACTTGYHWNEDCDCCQR...
A0A2I3ND23_PAPAN/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2I3SCA0_PANTR/89-129                ..HKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRR...
A0A1V4JWH1_PATFA/84-124                ..HKICDQGKALREVNPGNSTFQRQCACTMGYHWDEDCDCCQR...
A0A2K5Z955_MANLE/64-104                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2U3XK71_LEPWE/78-118                ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSADCDCCRR...
F7GWL8_CALJA/89-129                    ..HKVCDSGKALVAVDIGNSTAPRRCTCMVGYHWSQDCECCRR...
A0A2R8PDN2_CALJA/89-129                ..HKVCDSGKALVAVDIGNSTAPRRCTCMVGYHWSQDCECCRR...
A0A1D5Q245_MACMU/34-74                 ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A3Q7UUE8_URSAR/91-131                ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSADCDCCRR...
M7C7T0_CHEMY/65-105                    ..HKICDEGKGLIEVNPGNSTFQRQCACTLGYHCNEDCDYCLR...
A0A2I3MC10_PAPAN/34-74                 ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2K5EGC5_AOTNA/34-74                 ..HKVCDTGKALVAVDIGNSTAPRRCTCTAGYHWSQDCECCRR...
A0A1L1RVE1_CHICK/110-130               ..HKICDQGKALKEVNPGNS-----------------------icg
A0A2I2ZUF9_GORGO/89-129                ..HKVCDTGKALVAVDAGNSTTPRRCACTAGYHWSQDCECCRR...
A0A2K6UHI9_SAIBB/85-125                ..HKVCDTGKALVAVDIGNSTAPRRCTCTAGYHWSQDCECCRR...
A0A2I2UQD4_FELCA/89-129                ..HKVCDSGKALVAVEPGNRTAPRRCACTAGYHWSADCDCCRR...
A0A2R8ZKH6_PANPA/64-104                ..HKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRR...
A0A2R8ZKH9_PANPA/64-104                ..HKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRR...
F6WEI9_MACMU/89-129                    ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
H9GV25_ANOCA/87-127                    ..HKICDHGRALIEVNPGNSTSQRQCACTAGYHWNEDCDCCRR...
A0A2K5EG80_AOTNA/90-130                ..HKVCDTGKALVAVDIGNSTAPRRCTCTAGYHWSQDCECCRR...
A0A2Y9P9Q0_DELLE/65-105                ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSEDCRCCRR...
A4IIS3_XENTR/90-130                    ..HHICDSGKALKVAFRGNSTSPRKCVCEKGYHFSQDYEFCN-e..
M3YYJ4_MUSPF/67-107                    ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSADCDCCRR...
A0A1U7QXX5_MESAU/90-130                ..HKVCDAGKALVAVDPGNHTAPRRCACTAGYHWNPDCECCRR...
A0A2K5M0Z9_CERAT/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2I3GWV7_NOMLE/87-127                ..HKVCDTGKALVAVDPGNSTTPRRCACTAGYHWSQDCECCRR...
G1SNN2_RABIT/89-129                    ..HKVCDTGKALVAVDPGNSTAPRRCACTAGYHWSQDCECCRR...
U3KET4_FICAL/90-130                    ..HKICDQGKALREVNPGNSTFQRQCACTMGYHWSEDCDCCQR...
A0A2K5EG55_AOTNA/90-130                ..HKVCDTGKALVAVDIGNSTAPRRCTCTAGYHWSQDCECCRR...
G1N029_MELGA/71-111                    ..HKICDQGKALKEVNPGNSTFQRQCACTTGYHWNEDCDCCQR...
A0A2I3M6J3_PAPAN/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2K5M122_CERAT/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
H0VSX1_CAVPO/94-134                    ..HKVCDTGKALVAVDPGNRTAPRRCACTAGYHWSQDCECCRR...
A0A091IX96_EGRGA/68-108                ..HKICDQGKALIEVNPGNSTFQRQCACTMGYHWNEDCDCCQR...
A0A093H7I1_STRCA/71-111                ..HKICDQGKALKEVNPGNSTFQRQCACTTGYHWNDDCDCCQR...
A0A2K6KC87_RHIBE/87-127                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A096N6C9_PAPAN/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2K6F3J7_PROCO/89-129                ..HKVCDTGKALVAVDPGNRTAPRRCACTAGYHWSQDCECCRR...
F7AS58_MONDO/90-130                    ..HKVCDSGKGLTVVHPGNQTFPRQCACIPGYHWNGDSESCQR...
A0A093SA83_9PASS/68-108                ..HKICDQGKALREVNPGNSTFQRQCACTVGYHWDEDCDCCQR...
A0A493TPI5_ANAPP/84-124                ..HKICDQGKALKEVNPGNSTFQRQCACTTGYHWNEDCDCCQR...
A0A2Y9KJH5_ENHLU/106-146               ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSADCDCCRR...
A0A2R8ZNB7_PANPA/34-74                 ..HKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRR...
A0A2K6PQ79_RHIRO/67-107                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2K5QXK3_CEBCA/89-129                ..HKVCDTGKALVAVDIGNSTAPRRCTCTSGYHWSQDCECCRR...
A0A2K6F3N0_PROCO/89-129                ..HKVCDTGKALVAVDPGNRTAPRRCACTAGYHWSQDCECCRR...
A0A2K5Z943_MANLE/64-104                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A091FN17_9AVES/68-108                ..HKICDQGKALREVNPGNSTFQRQCACTMGYHWNEDCDCCRR...
TNR11_MOUSE/90-130                     ..HKVCDAGKALVAVDPGNHTAPRRCACTAGYHWNSDCECCRR...
#=GR TNR11_MOUSE/90-130          SS    ..-----GGGTEEEEETTSSSS--EEEE-TTEEEETTTTEEEE...
A0A2K6UHG5_SAIBB/98-138                ..HKVCDTGKALVAVDIGNSTAPRRCTCTAGYHWSQDCECCRR...
A0A452IZL2_9SAUR/84-124                ..HKICDEGRGLIEVNSGNRTFQRQCACTLGYHCNEDCDFCLR...
K7FKI7_PELSI/83-123                    ..HRICDEGKGLIEVNPGNSTFQRQCACTFGYHCNEDCDYCLR...
G1Q5Y9_MYOLU/71-107                    gp------GKALVPVEPGNRTAPRRCACTAGYHWSEDCDCCRR...
A0A2K5VA50_MACFA/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2K6KC18_RHIBE/87-127                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A3Q7S3R3_VULVU/68-108                ..HKVCDAGKALVAVEPGNRTAPRRCACTAGYHWSADCDCCRR...
K7GN73_PIG/89-129                      ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSEDCHCCRR...
E2QW81_CANLF/89-129                    ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSADCDCCRR...
A0A2U4BHP5_TURTR/89-129                ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSEDCRCCRR...
A0A2R8P9K9_CALJA/89-129                ..HKVCDSGKALVAVDIGNSTAPRRCTCMVGYHWSQDCECCRR...
G1PUF6_MYOLU/71-107                    gp------GKALVPVEPGNRTAPRRCACTAGYHWSEDCDCCRR...
A0A1S3WCA8_ERIEU/146-186               ..HKVCDAGKALVAVEPGNRTAPRRCACTSGYHWSADCRCCRR...
G1LI55_AILME/89-129                    ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSADCDCCRR...
A0A2K5VA61_MACFA/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2K6UHM4_SAIBB/85-125                ..HKVCDTGKALVAVDIGNSTAPRRCTCTAGYHWSQDCECCRR...
A0A099YWB6_TINGU/68-108                ..HKICDQGKALKEVNPGSSTSQRQCACMAGYHWNDDCDCCQR...
A0A151NFD7_ALLMI/84-124                ..HKICDKGKGLEEVNPGNRTFQRQCACHAGYHWDDAWDGCKR...
G1RBB3_NOMLE/87-127                    ..HKVCDTGKALVAVDPGNSTTPRRCACTAGYHWSQDCECCRR...
A0A2I3TEW2_PANTR/89-129                ..HKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRR...
A0A455AV43_PHYMC/129-169               ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSEDCRCCRR...
G3SDV3_GORGO/89-129                    ..HKVCDTGKALVAVDAGNSTTPRRCACTAGYHWSQDCECCRR...
A0A2K5QXN0_CEBCA/89-129                ..HKVCDTGKALVAVDIGNSTAPRRCTCTSGYHWSQDCECCRR...
A0A3Q7WCS7_URSAR/34-74                 ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSADCDCCRR...
I3LLE5_PIG/34-74                       ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSEDCHCCRR...
A0A452G3M0_CAPHI/67-107                ..HKVCDPGKALRAVEPGNRTAPRRCACTAGYHWSEDCRCCSR...
A0A3Q0H8Q8_ALLSI/84-124                ..HKICDKGKGLEEVNPGNRTFQRQCACHAGYHWDDAWDGCKR...
A0A384AXH0_BALAS/151-191               ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSEDCRCCRR...
A0A2R8M405_CALJA/89-129                ..HKVCDSGKALVAVDIGNSTAPRRCTCMVGYHWSQDCECCRR...
A0A2K6PQ90_RHIRO/67-107                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2K6B105_MACNE/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
G5BCN5_HETGA/134-174                   ..HKVCDTGKALVAVDPGNHTAPRRCACTAGYHWSQDCDCCRR...
A0A2R8P5V3_CALJA/89-129                ..HKVCDSGKALVAVDIGNSTAPRRCTCMVGYHWSQDCECCRR...
A0A1D5R192_MACMU/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A1D5QSR2_MACMU/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2I3RGN8_PANTR/89-129                ..HKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRR...
A0A2K5M109_CERAT/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
F7CYP7_HORSE/67-107                    ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSEDCDCCRR...
A0A2K6B0Z6_MACNE/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A226PX71_COLVI/84-124                ..HKICDQGKALREVNPGNSTFQRQCACTTGYHWNEDCDCCQR...
A0A2I3NCT5_PAPAN/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2K6F3K8_PROCO/89-129                ..HKVCDTGKALVAVDPGNRTAPRRCACTAGYHWSQDCECCRR...
H0XJB2_OTOGA/90-130                    ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSQDCECCRR...
F7ENY4_ORNAN/69-109                    .q-RVCDAGKALVAVHPGNSTSQRQCACTQGYHWSDDCDCCRR...
A0A2K5QXH5_CEBCA/89-129                ..HKVCDTGKALVAVDIGNSTAPRRCTCTSGYHWSQDCECCRR...
A0A1S3FE75_DIPOR/105-145               ..HKVCDTGKGLVALDPGNRTAPRRCVCTAGYHWSQDCQCCRR...
F1M8Z6_RAT/90-130                      ..HKVCDAGKALVAVDPGNHTAPRRCACTAGYHWNADCECCRR...
A0A1L8FXM9_XENLA/89-129                ..HHICDSGKALKVEFHGNSTAPRKCVCEEGYHFSHDYEFCN-k..
A0A2K5VA52_MACFA/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2Y9FXT3_TRIMA/348-388               ..HKVCDTGKALVAVEPGNRTAPRRCACTAGYHWSDDCACCRR...
A0A1L1RT12_CHICK/84-104                ..HKICDQGKALKEVNPGNS-----------------------icg
A0A2K6B110_MACNE/89-129                ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
A0A2R8ZNB3_PANPA/64-104                ..HKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRR...
A0A087R1Z5_APTFO/68-108                ..HKICDQGKALREVNPGNSTFQRQCACTMGYHWNEDCDCCQR...
A0A2K5QXI5_CEBCA/89-129                ..HKVCDTGKALVAVDIGNSTAPRRCTCTSGYHWSQDCECCRR...
A0A2I3RWV8_PANTR/89-129                ..HKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRR...
A0A2K5M140_CERAT/34-74                 ..HKVCDTGKALVAVDAGNSTAPRRCACTAGYHWSQDCECCRR...
#=GC SS_cons                           ..-----GGGTEEEEETTSSSS--EEEE-TTEEEETTTTEEEE...
#=GC seq_cons                          ..HKVCDTGKALVAV-sGNSTAPRRCACTAGYHWSpDCECCRR...
//
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