GenomeNet

Database: Pfam
Entry: RET_CLD1
LinkDB: RET_CLD1
Original site: RET_CLD1 
#=GF ID   RET_CLD1
#=GF AC   PF17756.1
#=GF DE   RET Cadherin like domain 1
#=GF PI   Cadherin_12;
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF00333
#=GF GA   26.40 26.40;
#=GF TC   26.40 27.70;
#=GF NC   26.30 26.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   25242331
#=GF RT   RET recognition of GDNF-GFRalpha1 ligand by a composite binding
#=GF RT   site promotes membrane-proximal self-association.
#=GF RA   Goodman KM, Kjaer S, Beuron F, Knowles PP, Nawrotek A, Burns EM,
#=GF RA   Purkiss AG, George R, Santoro M, Morris EP, McDonald NQ;
#=GF RL   Cell Rep. 2014;8:1894-1904.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   RET is a single transmembrane-spanning receptor tyrosine kinase
#=GF CC   (RTK) that plays critical roles in the development of
#=GF CC   vertebrates. Structural analysis indicate that RET contains four
#=GF CC   consecutive cadherin-like domains (CLD). This entry relates to
#=GF CC   the first CLD at the N-terminal. Several regions within RET-CLD1
#=GF CC   have been shown to be important for ligand-coreceptor binding.
#=GF CC   CLD1 and CLD2 have a distinctive clamshell shape and CLD1 is
#=GF CC   essential for CLD2 folding. CLD1 contains 2 sites for GDNF
#=GF CC   receptor alpha 1 binding [1].
#=GF SQ   136
#=GS A0A1V4KJU6_PATFA/20-143  AC A0A1V4KJU6.1
#=GS H2V9H3_TAKRU/25-145      AC H2V9H3.1
#=GS M7B044_CHEMY/4-127       AC M7B044.1
#=GS G3UPL6_MELGA/15-138      AC G3UPL6.1
#=GS U3IA91_ANAPL/31-154      AC U3IA91.1
#=GS A0A093JB64_FULGA/5-128   AC A0A093JB64.1
#=GS F1RG22_PIG/4-129         AC F1RG22.3
#=GS L9KW69_TUPCH/38-163      AC L9KW69.1
#=GS A0A091DS65_FUKDA/28-152  AC A0A091DS65.1
#=GS H2MFY1_ORYLA/4-121       AC H2MFY1.1
#=GS A0A093F326_GAVST/5-128   AC A0A093F326.1
#=GS A0A2K5HW60_COLAP/12-137  AC A0A2K5HW60.1
#=GS A0A1S3GMF6_DIPOR/50-175  AC A0A1S3GMF6.1
#=GS A0A091V1S7_PHORB/5-128   AC A0A091V1S7.1
#=GS H2NA70_PONAB/31-156      AC H2NA70.1
#=GS A0A1U7Q3L7_MESAU/29-154  AC A0A1U7Q3L7.1
#=GS A0A2I4C5X4_9TELE/27-144  AC A0A2I4C5X4.1
#=GS A0A2K5MKU6_CERAT/30-155  AC A0A2K5MKU6.1
#=GS W5KB50_ASTMX/26-146      AC W5KB50.1
#=GS A0A093FL16_TYTAL/5-128   AC A0A093FL16.1
#=GS A0A091UKF4_NIPNI/5-128   AC A0A091UKF4.1
#=GS H3A5G7_LATCH/10-129      AC H3A5G7.1
#=GS A0A091H1X3_BUCRH/5-128   AC A0A091H1X3.1
#=GS A0A2K5HW95_COLAP/4-129   AC A0A2K5HW95.1
#=GS F1PLF6_CANLF/21-147      AC F1PLF6.2
#=GS A0A2I3LXM4_PAPAN/7-132   AC A0A2I3LXM4.1
#=GS G3QLZ3_GORGO/29-154      AC G3QLZ3.1
#=GS A0A091LPX8_CARIC/5-128   AC A0A091LPX8.1
#=GS F6S299_MACMU/30-155      AC F6S299.2
#=GS A0A093CVF5_9AVES/5-128   AC A0A093CVF5.1
#=GS H2Q1T9_PANTR/31-156      AC H2Q1T9.2
#=GS Q4S3R8_TETNG/2-128       AC Q4S3R8.1
#=GS F7G7S6_MONDO/20-145      AC F7G7S6.2
#=GS RET_RAT/29-154           AC G3V9H8.1
#=GS A0A093GHA1_DRYPU/5-128   AC A0A093GHA1.1
#=GS A0A2I3H8C4_NOMLE/21-146  AC A0A2I3H8C4.1
#=GS J9P5A3_CANLF/29-155      AC J9P5A3.1
#=GS A0A2I2ZX13_GORGO/31-156  AC A0A2I2ZX13.1
#=GS G3WA34_SARHA/13-138      AC G3WA34.1
#=GS A0A091PLE8_HALAL/5-128   AC A0A091PLE8.1
#=GS A0A2I3TR47_PANTR/29-154  AC A0A2I3TR47.1
#=GS A0A093R0Z1_PHACA/4-127   AC A0A093R0Z1.1
#=GS A0A099YVI0_TINGU/5-128   AC A0A099YVI0.1
#=GS H2V9H6_TAKRU/21-141      AC H2V9H6.1
#=GS A0A1U7TWQ8_TARSY/3-128   AC A0A1U7TWQ8.1
#=GS A0A0F8CYI8_LARCR/32-151  AC A0A0F8CYI8.1
#=GS A0A091SF24_NESNO/5-128   AC A0A091SF24.1
#=GS K7FDV5_PELSI/20-143      AC K7FDV5.1
#=GS M3WI08_FELCA/31-157      AC M3WI08.2
#=GS H2V9H4_TAKRU/17-137      AC H2V9H4.1
#=GS A0A091K1G9_COLST/5-128   AC A0A091K1G9.1
#=GS A0A091KR79_9GRUI/5-128   AC A0A091KR79.1
#=GS A0A0Q3M0X4_AMAAE/22-145  AC A0A0Q3M0X4.1
#=GS I3JVT0_ORENI/27-147      AC I3JVT0.1
#=GS M4AIY3_XIPMA/30-146      AC M4AIY3.1
#=GS W5N0H5_LEPOC/23-145      AC W5N0H5.1
#=GS A0A151MT35_ALLMI/20-143  AC A0A151MT35.1
#=GS A0A091NLA0_9PASS/1-106   AC A0A091NLA0.1
#=GS A0A1U7R7D4_ALLSI/30-153  AC A0A1U7R7D4.1
#=GS A0A096P476_PAPAN/30-155  AC A0A096P476.1
#=GS A0A091RCP4_MERNU/5-128   AC A0A091RCP4.1
#=GS F7IQQ6_CALJA/5-88        AC F7IQQ6.1
#=GS A0A226N0H0_COLVI/23-140  AC A0A226N0H0.1
#=GS RET_MOUSE/29-154         AC P35546.2
#=GS F6WV32_HORSE/3-128       AC F6WV32.1
#=GS S9WFF8_CAMFR/57-182      AC S9WFF8.1
#=GS A0A1V4KJL4_PATFA/20-143  AC A0A1V4KJL4.1
#=GS F6ZPK1_ORNAN/94-219      AC F6ZPK1.2
#=GS H0Z7B3_TAEGU/5-127       AC H0Z7B3.1
#=GS A0A094L6M5_ANTCR/5-128   AC A0A094L6M5.1
#=GS A0A2I0MF50_COLLI/22-145  AC A0A2I0MF50.1
#=GS H0VQB6_CAVPO/23-147      AC H0VQB6.2
#=GS U3JWM3_FICAL/1-100       AC U3JWM3.1
#=GS F6ZPJ2_ORNAN/94-219      AC F6ZPJ2.2
#=GS A0A1L8FK90_XENLA/20-137  AC A0A1L8FK90.1
#=GS RET_HUMAN/29-154         AC P07949.3
#=GS RET_HUMAN/29-154         DR PDB; 4UX8 A; 29-154;
#=GS RET_HUMAN/29-154         DR PDB; 2X2U A; 29-154;
#=GS RET_HUMAN/29-154         DR PDB; 4UX8 B; 29-154;
#=GS G1S142_NOMLE/29-154      AC G1S142.1
#=GS A0A0P7TPP7_9TELE/1-114   AC A0A0P7TPP7.1
#=GS F1NL49_CHICK/20-143      AC F1NL49.3
#=GS A0A0A0AIM1_CHAVO/5-128   AC A0A0A0AIM1.1
#=GS A0A1W2PSA1_HUMAN/1-102   AC A0A1W2PSA1.1
#=GS G7PEQ9_MACFA/5-130       AC G7PEQ9.1
#=GS A0A2D0QL82_ICTPU/27-151  AC A0A2D0QL82.1
#=GS A0A093P9X3_PYGAD/5-128   AC A0A093P9X3.1
#=GS S7PB67_MYOBR/38-163      AC S7PB67.1
#=GS H2V9H8_TAKRU/2-129       AC H2V9H8.1
#=GS A0A094NP16_9AVES/11-134  AC A0A094NP16.1
#=GS A0A087V3R2_BALRE/4-127   AC A0A087V3R2.1
#=GS G3TIZ2_LOXAF/27-152      AC G3TIZ2.1
#=GS A0A091K456_EGRGA/5-128   AC A0A091K456.1
#=GS A0A0D9REZ9_CHLSB/12-137  AC A0A0D9REZ9.1
#=GS M3Z0Q6_MUSPF/1-108       AC M3Z0Q6.1
#=GS A0A091TJE9_PHALP/5-128   AC A0A091TJE9.1
#=GS F1MS00_BOVIN/28-153      AC F1MS00.2
#=GS A0A1L1RML1_CHICK/20-142  AC A0A1L1RML1.1
#=GS A0A091NNN1_APAVI/5-128   AC A0A091NNN1.1
#=GS A0A091WFB4_OPIHO/5-128   AC A0A091WFB4.1
#=GS H2V9H5_TAKRU/28-148      AC H2V9H5.1
#=GS A0A093HZ58_STRCA/5-128   AC A0A093HZ58.1
#=GS G1MR14_MELGA/30-153      AC G1MR14.1
#=GS F1R376_DANRE/23-140      AC F1R376.2
#=GS H9G9F1_ANOCA/5-132       AC H9G9F1.1
#=GS A0A091LHQ6_CATAU/5-128   AC A0A091LHQ6.1
#=GS A0A1A6GT22_NEOLE/9-134   AC A0A1A6GT22.1
#=GS F7I536_CALJA/31-156      AC F7I536.1
#=GS A0A091GAH5_9AVES/5-128   AC A0A091GAH5.1
#=GS A0A1S3N2X8_SALSA/26-140  AC A0A1S3N2X8.1
#=GS A0A091IUX9_CALAN/5-128   AC A0A091IUX9.1
#=GS A0A1S3RRC1_SALSA/26-141  AC A0A1S3RRC1.1
#=GS G3HKS9_CRIGR/9-134       AC G3HKS9.1
#=GS G3NG57_GASAC/26-144      AC G3NG57.1
#=GS G1MES8_AILME/33-159      AC G1MES8.1
#=GS W5P1A8_SHEEP/41-166      AC W5P1A8.1
#=GS I3LYN9_ICTTR/27-152      AC I3LYN9.2
#=GS Q9BTX6_HUMAN/29-154      AC Q9BTX6.1
#=GS A0A226NKL3_CALSU/25-148  AC A0A226NKL3.1
#=GS A0A1W2PPN7_HUMAN/1-102   AC A0A1W2PPN7.1
#=GS A0A093CL96_TAUER/5-128   AC A0A093CL96.1
#=GS F7DU26_XENTR/11-134      AC F7DU26.1
#=GS A0A091Q7W3_LEPDC/5-128   AC A0A091Q7W3.1
#=GS G1PWX2_MYOLU/9-134       AC G1PWX2.1
#=GS A0A218UTR5_9PASE/20-142  AC A0A218UTR5.1
#=GS H2V9H7_TAKRU/20-141      AC H2V9H7.1
#=GS A0A1S3H9Z7_LINUN/26-157  AC A0A1S3H9Z7.1
#=GS V8P465_OPHHA/30-142      AC V8P465.1
#=GS A8E7C6_DANRE/23-140      AC A8E7C6.1
#=GS A0A091F9U6_CORBR/4-127   AC A0A091F9U6.1
#=GS G1T0Q2_RABIT/29-154      AC G1T0Q2.2
#=GS L5KWJ8_PTEAL/3-128       AC L5KWJ8.1
#=GS G3UR22_MELGA/15-138      AC G3UR22.1
#=GS G5BD17_HETGA/1-95        AC G5BD17.1
#=GS H0X4E9_OTOGA/14-139      AC H0X4E9.1
#=GS A0A087R166_APTFO/5-128   AC A0A087R166.1
#=GS A0A091S7L4_9GRUI/5-128   AC A0A091S7L4.1
#=GS H1A1E9_TAEGU/5-127       AC H1A1E9.1
#=GS F6S7W7_MACMU/30-155      AC F6S7W7.2
A0A1V4KJU6_PATFA/20-143             ...LYFPRKDYSENVYV.....DQPAGTPLLRIHALRDSHGEVAH...FHLCQNLI..ISRARSHENNWFQIREKTGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....ATVFLSLINATA......................................................
H2V9H3_TAKRU/25-145                 ...LYFSQNEYIETVYV.....GQPAGTPVLQVHAMRDGDTERPH...FYLCSM--..NSRRRPAHVSWFRLDISTGVLSLNKTLEESDFASF....YP...SS--QSVKKLSMHVMALPGFTKNSLC.NSRSC....PRINLEFVNATM......................................................
M7B044_CHEMY/4-127                  ...LYFPRKDYSETVYI.....DQPAGTPLLHIRALRDSHGEVAH...FQLCQHLF..IYRVGAYENHWFQIKEKTGLLYLNKSLDRGDFDIL....FG...RNW-VSLPKVTFHVYLSSQPFQGKEC.ETPIS....ALVHLSILNATV......................................................
G3UPL6_MELGA/15-138                 ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGESAH...FHLCQNLI..ISRARSHENHWFQIREKMGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVVLSLINATA......................................................
U3IA91_ANAPL/31-154                 ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGEAAH...FHLCQNLV..ISRARSHENHWFQIREKTGLLYLSRSVDREDFNML....SV...GNW-MTLSKVMLYVFLSSHPFQEKEC.DSATR....TTVVLSLINATA......................................................
A0A093JB64_FULGA/5-128              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHTLRDSHGEVAH...FHLCQNLI..ISRARSHENHWFQIREKTGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSAMR....TTVFLSLINATA......................................................
F1RG22_PIG/4-129                    ...LYFSRDAYWEKLYV.....DQPAGMPLLYVHALQDVPGEVPS...FRLGQHLY.gVYRTRLHENDWIRIQEDTGLLYLNQSLDHSSWEKL....SI...RNGGFPLLTVYLQVFLSPASLRESEC.QWPGC....ARVYFSFINAS-f.....................................................
L9KW69_TUPCH/38-163                 ...LYFSRDTYQEKLYV.....GQPAGTPLLYVRALQDAPGEVPS...FRLGQYLY.gSSRMRLHENSWIRVQEDTGLLYLNRSLDHSSWEKL....SI...RNGGFPLLTVYLHVFLSPVSLREGKC.HWPGC....ACVSFSFINTS-f.....................................................
A0A091DS65_FUKDA/28-152             ...LYFPRDAYWERLYL.....DQPAGTPLLYVHALQDAPGEVPS...FHLGQHLY.gVYHKPLHKNDWIHV-EDTGLLYLNRSLDRNSWEQL....SL...RNGGFPLLTIFLHVFLSSPPLREGEC.HWPGC....TRVYFSFINAS-f.....................................................
H2MFY1_ORYLA/4-121                  ...LYFPQKEYIETVYV.....GQPAGTPVLQVHAMQDSAAERPH...FSLCWA--..---RRPYYASWFHMDVTTGVLYLNRTLEPADFSSQ....YP...TSW--PVKRLSVQAVVSNSFIKGSQC.AAKRK....ALITLDFVNATM......................................................
A0A093F326_GAVST/5-128              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGEVAH...FHLCQNLI..ISRARSHENHWFQIRGRTGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
A0A2K5HW60_COLAP/12-137             ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNQSLDRSSWEKL....SG...RNRGFPLLTVYLKVFLSPTSLREGEC.QWPGC....ARVYFSFFNTS-f.....................................................
A0A1S3GMF6_DIPOR/50-175             ...LYFSRDAYWERLYL.....DQPAGTPLLYVQALRDTPDEVPS...YHLGQHLY.gAYRTRLHENDWIRIQEDTGLLYLNQSLDHSTWEKL....SI...RNGGFPLLTVFLQIFLSSLPVRESEC.QWPTC....ARVYFSFINAS-f.....................................................
A0A091V1S7_PHORB/5-128              ...LYFPRKEYLENVYI.....DQPAGTPLLRIHALRDSHGEVAH...FHLCQNLI..VSRARSHENHWFQIREKTGLLYLSKTLDREDFNML....SV...GNW-MSLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
H2NA70_PONAB/31-156                 ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDTPEEVPS...FHLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDHNSWEKL....SV...RNRGFPLLTVYLKVFLSPTSLRESEC.QWPGC....ARVYFSFFNTS-f.....................................................
A0A1U7Q3L7_MESAU/29-154             ...LYFSRDAYWERLYV.....DQPAGTPLLYVHALRDAPEEVPS...FRLGQHLY.sAYRTRLHENDWIRIHEDTGLLYLNQSLDHSSWEQL....SI...RNGGFPLLTIFLQVFLGSTTQREGEC.HWPGC....ARVYFSFINDS-f.....................................................
A0A2I4C5X4_9TELE/27-144             ...LYFPQKEYIETVYV.....GQPAGTPVLQIHAMLDSDSEKPH...LYLCES--..---RHSPYSTWFHLNPSTGVLSLRKTLEEVDFSSL....SQ...GLW--QRKKLSLQAAVLTTVIRRSQC.NPQKT....AHITLEFXNAS-v.....................................................
A0A2K5MKU6_CERAT/30-155             ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDSPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKL....SG...RNRGFPLLTVYLKVFLSPTSLREGEC.QWPGC....ARVYFSFFNTS-f.....................................................
W5KB50_ASTMX/26-146                 ...LYFPQNLYSETIYV.....GQPAGAPLLQVHSMRETSSERPY...FSLCWR--..NVQKPPLIAAWFHIDPVSGVLYMNKTLEWTDFDSL....SS...SAF-GHAKKLILKVVAA-PGNQRSIC.LHHTK....VDVSLTFLNTTA......................................................
A0A093FL16_TYTAL/5-128              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGEMAH...FHLCQNLI..ISRARSHENHWFQIREKTGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
A0A091UKF4_NIPNI/5-128              ...LYFPRKEYSENVYI.....DQAGGTPLLRIHALRDSHGEVAH...FHLCQNLI..ISRARSHENHWFQIREKTGLLYLSKSLDREDFNML....SV...GSW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
H3A5G7_LATCH/10-129                 ...LYFPKKVYSENVYV.....NQPAGTPLLYLCALREDENEVVR...FKVCRMLV.pHTHSSAKRNKWFEIDENSGFLYLNHTLDKWDFNDL....SK...HSMGDKVAVLKLKLLVS----ASGDC.--ETT....MSVILTVLNTTV......................................................
A0A091H1X3_BUCRH/5-128              ...LYFPRKEYSENVYI.....GQPAGTPLLRIHALKDSYREVAH...FHLCQNLI..ISRARSHENHWFQIREKTGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMVYVFLSSHPFQEKEC.DSATR....TTVFISFINAT-t.....................................................
A0A2K5HW95_COLAP/4-129              ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNQSLDRSSWEKL....SG...RNRGFPLLTVYLKVFLSPTSLREGEC.QWPGC....ARVYFSFFNTS-f.....................................................
F1PLF6_CANLF/21-147                 ...LYFSRDAYWEKLYV.....DQPSGMPLLYVHALRDIPEEVPS...FRLGQHLYgiAYRARLHENDWIRIEEDTGLLYLNRSLDHSTWEKL....SI...RNGGFPVLTIYVQVFLSSASLREGEC.QWPGC....ARVYFSFINTS-f.....................................................
A0A2I3LXM4_PAPAN/7-132              ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDRSSWEKL....SG...RNRGFPLLTVYLKVFLSPTSLREGEC.QWPGC....ARVYFSFFNTS-f.....................................................
G3QLZ3_GORGO/29-154                 ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALQDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKL....SV...RNRGFPLLTVYLKVFLSPTSLREGEC.QWPGC....ARVYFSFFNTS-f.....................................................
A0A091LPX8_CARIC/5-128              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGEAAH...FHLCQNLI..VSRARSHENHWFQIREKTGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
F6S299_MACMU/30-155                 ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDRSSWEKL....SG...RNRGFPLLTVYLKVFLSPTSLREGEC.QWPGC....ARVYFSFFNTS-f.....................................................
A0A093CVF5_9AVES/5-128              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGEVAH...FHLCQNLI..ISRARSHENNWFEIREKTGLFYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSAMR....TTVFLSLINATA......................................................
H2Q1T9_PANTR/31-156                 ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKL....SV...RNRGFPLLTVYLKVFLSPTSLREGEC.QWPGC....ARVYFSFFNTS-f.....................................................
Q4S3R8_TETNG/2-128                  ...LYFSQSEYIETVYV.....GQPAGTPVLQVHALRDNVTELPH...FYLCWV--..KFLRRPAYISWFSLDVNTGVLYLNKTLEESDFASVcepyTS...NQSNQAVKKLSLHVMASPGFTKKPLC.NSRNY....PRITLDFVNAMM......................................................
F7G7S6_MONDO/20-145                 ...LYFSRDTYSEKLYV.....DEPAGTPLLYVHALQDTRGEVPH...FHLGQHLY.sTYRSQSHKNDWFQINEDTGLLYLNQSLDQRALEKL....SA...RNGGFPLRTIYLQVFLSPKPFQEHEC.HWPSC....AKVMLFIINATM......................................................
RET_RAT/29-154                      ...LYFSRDAYWERLYV.....DQPAGTPLLYVHALRDAPGEVPS...FRLGQYLY.gVYRTRLHENDWIHIDSGTGLLYLNQSLDHSSWEQL....SI...RNGGFPLLTVFLQVFLGSTAQREGEC.HWPGC....ARVYFSFINDTF......................................................
A0A093GHA1_DRYPU/5-128              ...LYFPRKEYSENVYV.....DQPAGTPLLHIHALRDSHGEVAH...FHLCQNLV..ISRARSHENHWFQIREKTGLLHLSKSLDREDFNML....SV...GNL-VQLSKVMLYVFLSPHPFQEKEC.DSATR....TTVFLSLINAS-a.....................................................
A0A2I3H8C4_NOMLE/21-146             ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKL....SV...RNRGFPLLTVYLKVFLSPTSLGEGEC.QWPGC....ARVYFSFFNTS-f.....................................................
J9P5A3_CANLF/29-155                 ...LYFSRDAYWEKLYV.....DQPSGMPLLYVHALRDIPEEVPS...FRLGQHLYgiAYRARLHENDWIRIEEDTGLLYLNRSLDHSTWEKL....SI...RNGGFPVLTIYVQVFLSSASLREGEC.QWPGC....ARVYFSFINTS-f.....................................................
A0A2I2ZX13_GORGO/31-156             ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALQDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKL....SV...RNRGFPLLTVYLKVFLSPTSLREGEC.QWPGC....ARVYFSFFNTS-f.....................................................
G3WA34_SARHA/13-138                 ...LYFSRDTYSEKLYI.....DEPVGTPLLYVHALQDARGEVPH...FRLGQHLY.sTYRSQPHKNDWFQINEDTGLLYLNQSLDQRALEKL....SA...RNGGFPLLTIYLQVFLSPKPLRESDC.HWPSC....AKVMLSVINTTM......................................................
A0A091PLE8_HALAL/5-128              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGEVAH...FHLCQNLV..ISRARSHENHWFQIREKTGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
A0A2I3TR47_PANTR/29-154             ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKL....SV...RNRGFPLLTVYLKVFLSPTSLREGEC.QWPGC....ARVYFSFFNTS-f.....................................................
A0A093R0Z1_PHACA/4-127              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGEVAH...FHLCQNLI..ISRARSHENHWFQIREKTGLLYLSKSLDREDFNIL....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
A0A099YVI0_TINGU/5-128              ...LYFPRKEYSENVYI.....DQAAGTPLLHIRALRDSHGEVAH...FHLCQNLV..ISRARSHENHWFQIREKTGLLYLSKNLDREDFNML....SV...GNW-MSLSKVMLYVFLSSHPFQEKEC.DSATR....ATVYLSLINATA......................................................
H2V9H6_TAKRU/21-141                 ...LYFSQNEYIETVYV.....GQPAGTPVLQVHAMRDGDTERPH...FYLCSM--..NSRRRPAHVSWFRLDISTGVLSLNKTLEESDFASF....YP...SS--QSVKKLSMHVMALPGFTKNSLC.NSRSC....PRINLEFVNATM......................................................
A0A1U7TWQ8_TARSY/3-128              ...LYFSRDAYWEKLYV.....DQPAGMPLLYVHALQDAPGEVPS...FRLGQHLY.gAYRTRLHDNNWIRIQEDTGLLYLNRSLDHSSWEKL....SI...RNGGFPLLTVYLQVFLPFMSLREVEC.HWPGC....ARVYFSFINAS-f.....................................................
A0A0F8CYI8_LARCR/32-151             ...LYFPQNEYIETVYV.....GQQAGTPILQVHAMLDSDSERPH...FYLCWT--..-ISHRHPYSSWFNLDINTGILSLNKTLEESDFALL....NQ...KS--PFVMKLSLKAMVLPYFTKKPQC.NSRSF....FRITLDFVNATM......................................................
A0A091SF24_NESNO/5-128              ...LYFPRKEYLENVYI.....DEPAGTPLLRIHTLRDSHGEVAH...FHLCQNLI..ISRARSHENNWFQIREKTGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLMNATA......................................................
K7FDV5_PELSI/20-143                 ...LYFPRKEYSENVYI.....DQPAGTPLLHIHALRDSHGEVAH...FQLCQRLS..IYRVGSYENHWFQIREKTGLLYLNKSLDRGDFDIL....FG...RNW-MSLPKVTFPVYLSSQPFQGKEC.ETSTS....AVVHLFIINATA......................................................
M3WI08_FELCA/31-157                 ...LYFARDAYWEKLYV.....DQPAGMPLLYVHALRDMPEEVPT...FRLGQHLYgiAYRARLHENEWIRIEEDTGLLYLNRSLDHSTWDKL....SI...RNGGFPVLTIYLQVFLSPTSLREGEC.QWPSC....ARVYFSFVNTS-f.....................................................
H2V9H4_TAKRU/17-137                 ...LYFSQNEYIETVYV.....GQPAGTPVLQVHAMRDGDTERPH...FYLCSM--..NSRRRPAHVSWFRLDISTGVLSLNKTLEESDFASF....YP...SS--QSVKKLSMHVMALPGFTKNSLC.NSRSC....PRINLEFVNATM......................................................
A0A091K1G9_COLST/5-128              ...LYFPRKEYSENVYI.....DQPVGTPLLRIHALRDSHGEVAH...FYLCQNLI..VSRARSHENRWFQIREKTGLLYLDKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSAIR....TTVFLSLINATA......................................................
A0A091KR79_9GRUI/5-128              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGEVAH...FHLCQNLI..VSRARSHENNWFQIREKTGLLYLSQSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
A0A0Q3M0X4_AMAAE/22-145             ...LYFPRKEYLENVYI.....DEPAGTPLLRIHTLRDSHGEVAH...FRLCQNLI..ISRARSHENNWFQIXEKTGVLYLSKTLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEXEC.DSATR....TTVFLSLMNATA......................................................
I3JVT0_ORENI/27-147                 ...LYVPQNEYIETVYV.....GQQAGTPVLQVHAMQDNKSEKPH...FYLCPT--..KTAMPSHYGSWFYMNINTGTLFLNKTLEESDFAQL....YQ...RSR--SVRKLFLQTMVRSEFTNKPLC.LMRKP....VQIILDFVNAT-l.....................................................
M4AIY3_XIPMA/30-146                 ...LYFPQKEYTETVYV.....GQPAGTPVLQVHAMLDGRSERPH...FYLCGS--..---RRPPYALWFQMDVQTGELSLSKTLEETDFASL....YQ...NSW--PAKRLTLQVMALNSVSKRAPC.-SRNS....AHITLDFVNGSM......................................................
W5N0H5_LEPOC/23-145                 ...LYFPQKKYSENVFV.....GQPAGTPILQLHVMLDNESETAH...FCLRQLTE..YPKIKL-----FHLDERTGLLSLNRTLDWSDFAPP....S-...NSWTGPVKKLPLLARASQKPFRDKSC.HGQTVhgqdVSIYINFYNTTA......................................................
A0A151MT35_ALLMI/20-143             ...LYFPRREYSENVYI.....DQPAGTPLLHIHALQDFHGEEVH...FQLCQRIL..IHRIGTHENQWFQIKEKTGLLYLNKSLDRGDFDIL....SG...GNW-VSLPKAVLQVSLSSHPFQGKKC.ESPTY....AVVSLFIINATA......................................................
A0A091NLA0_9PASS/1-106              ...--------------.....----GTPLLRIHALKDSPEESAH...FHLCQNLI..ISRARSHENHWFQIREKTGLLYLSKSLDREDFNML....SV...GNW-MSLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLNNATA......................................................
A0A1U7R7D4_ALLSI/30-153             ...LYFPRREYSENVYI.....DQPAGTPLLHIHALQDFHGEEVH...FQLCQRIL..IHRIGTHENQWFQIKEKTGLLYLNKSLDRGDFDIL....SG...GNW-VSLPKAVLQVSLSSHPFQGKKC.ESPTY....AVVSLFIINATA......................................................
A0A096P476_PAPAN/30-155             ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDRSSWEKL....SG...RNRGFPLLTVYLKVFLSPTSLREGEC.QWPGC....ARVYFSFFNTS-f.....................................................
A0A091RCP4_MERNU/5-128              ...LYFPRKEYSENVYI.....DQPAGMPLLRIHALRDSHGEVAH...FHLCQNLI..ISRARSHENHWFQIREKTGLLYLSKTLDREDFNML....SV...GHW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSVINATA......................................................
F7IQQ6_CALJA/5-88                   ...LYFSRDAYWENLYV.....DQLASTPLLYVHALQDTPGEVPS...FCLGQHLY.gTYHMWLHKNNWIPIQEDTGLLYLNWILDQRTWEKL....S-...--------------------------.-----....------------vc....................................................
A0A226N0H0_COLVI/23-140             ...LYFPRKEYSENVYI.....DQPAGTPLLHIHALRDSHGETAH...FHLCQNII..VSRARSHENHWFQIREKMGLLYLSKSLDREDFNML....SE...GMP-FRYNENTTGVSVT---------.-----....------------qrldreereryeliakctvr..................................
RET_MOUSE/29-154                    ...LYFSRDAYWERLYV.....DQPAGTPLLYVHALRDAPGEVPS...FRLGQHLY.gVYRTRLHENDWIRINETTGLLYLNQSLDHSSWEQL....SI...RNGGFPLLTIFLQVFLGSTAQREGEC.HWPGC....TRVYFSFINDTF......................................................
F6WV32_HORSE/3-128                  ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDVPEEVPT...FRLGQHLY.gAYRTRLHENDWIRIQEDTGLLYLNQSLDHSSWEQL....SV...RKGGFPRTPAVKPVFPSATSCPWGKM.TAPIC....QRKFESWIHTS-f.....................................................
S9WFF8_CAMFR/57-182                 ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDVPEEVPS...FRLGQHLY.gAYRTRLHENDWIRIQEDTGLLYLNRSLDHSSWEKL....SI...RNGGFPLLTVYLQVFLSPASLREGEC.QWPGC....ARVYFSFINAS-f.....................................................
A0A1V4KJL4_PATFA/20-143             ...LYFPRKDYSENVYV.....DQPAGTPLLRIHALRDSHGEVAH...FHLCQNLI..ISRARSHENNWFQIREKTGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....ATVFLSLINATA......................................................
F6ZPK1_ORNAN/94-219                 ...LYFPRDTYSEKLYV.....DQPAGTPLLYVQALRDSQQEVPR...FQLGQHLY.gSYRSQLHENLWFQIHEDTGLLYVNRSLGWKDLKSL....RA...LNGGYPLLNIHLHVFLSPKPFWENEC.LWPSC....AKVSLSIINTTA......................................................
H0Z7B3_TAEGU/5-127                  ...LYFPRKEYLENVYI.....DEPAGMPLLRIHALRDSHEEVAH...FHLCQHLI..VPRARPQENNWFQIREKTGLLYLSKSLDREDFNML....SV...GSW-MPLSKVMLYVSVS-HPFQEKDC.DSATR....TTVFLSLINATA......................................................
A0A094L6M5_ANTCR/5-128              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGEVAH...FHLCQNLV..ISRARSHENHWFQIREKTGLLYLSKSLDREDFSML....SV...GNW-MPLSKVMLYVFLSSHPFQENEC.DSATR....TTVFLSLINAT-s.....................................................
A0A2I0MF50_COLLI/22-145             ...LYFPRKEYSENVYV.....DQPAGTPLLRIHALRDSHGEVAH...FHLCQNLI..ISRARSHENNWFQIREKTGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....ATVFLSLINATA......................................................
H0VQB6_CAVPO/23-147                 ...LYFPRDAYREQLYL.....DQPAGTPLLYVHALRDTPEELPS...FHLGQHLY.nIYHKPLHRNDWIRV-EDTGLLYLNRSLDLGSWEQL....SL...RNGGFPLLTIFLHVFLSSPPLREGEC.HWPGC....ARVYFSFINAS-f.....................................................
U3JWM3_FICAL/1-100                  ...--------------.....-----MPLLRIHALKDSPEEVAH...FHLCQNLI..ISR-GRHENNWFQIKEKSGVLYLSKSLDREDFNML....SV...GNW-KPLPKVMLYV----HPFQEKEC.DSTTR....TTVFLSLINGTA......................................................
F6ZPJ2_ORNAN/94-219                 ...LYFPRDTYSEKLYV.....DQPAGTPLLYVQALRDSQQEVPR...FQLGQHLY.gSYRSQLHENLWFQIHEDTGLLYVNRSLGWKDLKSL....RA...LNGGYPLLNIHLHVFLSPKPFWENEC.LWPSC....AKVSLSIINTTA......................................................
A0A1L8FK90_XENLA/20-137             ...LYFLRKDYSENLYM.....DQPAGTLLLQVHVMKDSPLEKPH...F--CQN--..IYLSRL--VHWFRIDEHTGILYLNRSLDRSVYEVF....SQ...GSQ-SSIQKITLKVSIKPQPFLDKDC.DNAPF....ILVYLYFINHT-s.....................................................
RET_HUMAN/29-154                    ...LYFSRDAYWEKLYV.....DQAAGTPLLYVHALRDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKL....SV...RNRGFPLLTVYLKVFLSPTSLREGEC.QWPGC....ARVYFSFFNTS-f.....................................................
#=GR RET_HUMAN/29-154         SS    ...-EES-SEEEEEEET.....TB-TT-EEEE--EE-SSTT----...-EE-SEEE.-GGG-EEEE--SEEE-TTT-EEEESS-B-HHHHHHH....HH...TSTTS---EEEEEEES----------.-TTTE....EEEEEEEESS---.....................................................
G1S142_NOMLE/29-154                 ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKL....SV...RNRGFPLLTVYLKVFLSPTSLGEGEC.QWPGC....ARVYFSFFNTS-f.....................................................
A0A0P7TPP7_9TELE/1-114              ..m---------ESVYV.....GQQAGSPVLQLHAMADTEQERPR...FFLCWS--..NMLKPQHYSSWFTLDENTGILSMNKTLDWSDFSGL....I-...KSTSETVKLLTLTAEAVPRTHGSSGC.GGSLS....VPILISFISATV......................................................
F1NL49_CHICK/20-143                 ...LYFPRKEYSENVYI.....DQPAGAPLLRIHALRDSHGETAH...FHLCQNLI..ISRARSHENHWFQIREKMGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVVLSLINATA......................................................
A0A0A0AIM1_CHAVO/5-128              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGEVAH...FHLCQNLV..ISRARSHENHWFQIREKTGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
A0A1W2PSA1_HUMAN/1-102              ..x-----DAYWEKLYV.....DQAAGTPLLYVHALRDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKL....SV...RTC-----------------------.-----....------------sslkprelcfpetrpsfrir..................................
G7PEQ9_MACFA/5-130                  ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDRSSWEKL....SG...RNRGFPLLTVYLKVFLSPTSLREGEC.QWPGC....ARVYFSFFNTS-f.....................................................
A0A2D0QL82_ICTPU/27-151             ...LYFPQTTYSESIYV.....GQAAGTPVLQVHAMQERASEQPY...FCLYRM--..PVLKPAAYGSWFHIDTVTGVIYMNKTLDWTDFESI....YSsrpVQKGKETMKLTLKVSVD-VMSPKKLC.SQITN....VDVSFTFINATA......................................................
A0A093P9X3_PYGAD/5-128              ...LYFPRKEYLENVYI.....DQPAGTPLLRIHALRDSHGEVAH...FHLCQNLI..VSRARSHENHWFQIREKTGLLYLSKSLDREDFNVL....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
S7PB67_MYOBR/38-163                 ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDAPDEVPS...FRLGQHLY.gAYRKRLHENDWIRIQEDTGLLYLNWSLNHSSWEKL....NI...RNGGFPQLTVYLQVFLLPTPLREGEC.QWPGC....ARIYFSFINAS-f.....................................................
H2V9H8_TAKRU/2-129                  ...LYFSQNEYIETVYV.....GQPAGTPVLQVHAMRDGDTERPH...FYLCSM--..NSRRRPAHVSWFRLDISTGVLSLNKTLEESDFASFc.elYAg.rDPSSQSVKKLSMHVMALPGFTKNSLC.NSRSC....PRINLEFVNATM......................................................
A0A094NP16_9AVES/11-134             ...LYFPRKEYLENVYL.....DQPAGAPLLRIHALRDSHGEVAH...FHLCQNLV..ISRARSHENHWFQIREKTGLLYLSRSLDRDDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
A0A087V3R2_BALRE/4-127              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGETAH...FHLCQNLI..ISRARSHENHWFQIREKTGLLYLSKNLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....ATVFLSLINATA......................................................
G3TIZ2_LOXAF/27-152                 ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHTLQDLPGEVPS...FRLGQHLY.gAYRSRLHENDWIRIQEDMGLLYLNQSLDQSTWEEL....SS...RNGGFPLLTVHLQVFLSPASLREGEC.SGPGC....ARVYFSFINAS-f.....................................................
A0A091K456_EGRGA/5-128              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSRGEATH...FHLCQNLI..VSRARSHENHWFQIREKTGLLYLSKSLDREDFNML....SV...GSW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
A0A0D9REZ9_CHLSB/12-137             ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDRSSWEKL....SG...RNRGFPLLTVYLKVFLSPTFLREGEC.QWPGC....ARVYFSFFNTS-f.....................................................
M3Z0Q6_MUSPF/1-108                  ...--------------.....-----MPLLYVHALRDAPEEVPS...FRLGQHLYgiAYRARLQENDWIRIEEDTGLLYLNRSLDHSAWERL....SI...RNGGFPVLTIYLQVFLSSAFLREGEC.QWPGC....ARVYFSFINTS-f.....................................................
A0A091TJE9_PHALP/5-128              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGEVAH...FHLCQNLI..ISRARSHENHWFQIREKTGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSAMR....TTVFLSLINATA......................................................
F1MS00_BOVIN/28-153                 ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDVPEEVPS...FRLGQHLY.gAYRTRLHENDWVRIQEDTGLLYLNQSLDHSSWEKL....NI...RNGGFPLLTVYLWVFLSPASVREGEC.QWPGC....ARVYFSVINAS-f.....................................................
A0A1L1RML1_CHICK/20-142             ...LYFPRKEYSENVYI.....DQPAGAPLLRIHALRDSHGKQPT...F-ICARII..ISRARSHENHWFQIREKMGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVVLSLINATA......................................................
A0A091NNN1_APAVI/5-128              ...LYFPRKEYSENVYL.....DQPAGTPLLHIHALRDSRGEVTH...FHLCQNLI..ISRARSHENHWFQIKEKTGLLYLSKSLDREDFNML....ST...GNW-MSLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
A0A091WFB4_OPIHO/5-128              ...LYFPRKEYSENVYM.....DQPAGTPLLRIHALRDSHGEVAR...FHLCQNLI..ISRARSLANNWFQIREKTGLLYLSKSLDREDFNML....PV...GNW-IPLSKVVLYVFLSSHPFQEKEC.DSAMR....TTVFLSLINATA......................................................
H2V9H5_TAKRU/28-148                 ...LYFSQNEYIETVYV.....GQPAGTPVLQVHAMRDGDTERPH...FYLCSM--..NSRRRPAHVSWFRLDISTGVLSLNKTLEESDFASF....YP...SS--QSVKKLSMHVMALPGFTKNSLC.NSRSC....PRINLEFVNATM......................................................
A0A093HZ58_STRCA/5-128              ...LYFPRKEYSENVYI.....DQAAGTPLLHIHALRDSHGEAAH...FHLCQNLI..ISRARSHENHWFQIREKTGLLYLSKSLDREDFNML....SV...GNW-MSLSKVMLYVFLSSHPFQEKEC.DSATR....ATVYLSLINATA......................................................
G1MR14_MELGA/30-153                 ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGESAH...FHLCQNLI..ISRARSHENHWFQIREKMGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVVLSLINATA......................................................
F1R376_DANRE/23-140                 ...LYFPQRLYTENIYV.....GQQQGSPLLQVISMREFPTERPY...FFLCSH--..----RDAFTSWFHIDEASGVLYLNKTLEWSDFSSL....RS...GSV-RSPKDLTLKVGVSSTPPMKVMC.TILPT....VEVKLSFINDTA......................................................
H9G9F1_ANOCA/5-132                  ...LYFPRKDYHENVYL.....DQPGGSPLLQIHALKDSEKEKIY...FWLCPQLH..IPGVGIKDNLWFQIKEKTGLLFLNKSLDREDFETLf.liVA...GNW-MSMPKLILQVYLTSQPLQGKDCrESYNK....ALVKLSVINGTM......................................................
A0A091LHQ6_CATAU/5-128              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGEVAH...FHLCQNLI..ISRARSHENHWFQIREKIGLLYLSKSVDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
A0A1A6GT22_NEOLE/9-134              ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDAPEEVPS...FRLGQHLS.sAFRTRLHENDWIRIHEDTGLLYLNQSLDHSSWEQL....SI...RNGGFPLLTIFLQVFLSSATQRGGEC.HWPGC....AHVYFSLINDS-f.....................................................
F7I536_CALJA/31-156                 ...LYFSRDAYWENLYV.....DQPASMPLLYVHALRDTPGEVPS...FRLGRHLY.gTYHTRLHENNWIRIQEDTGLLYLNQSLDQRTWEKL....SV...RNGGFRVFTVYLKVFLSPTSLREGEC.QWPGC....ARVYFSFFNTS-f.....................................................
A0A091GAH5_9AVES/5-128              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGEAAH...FHLCQNLI..ISRARSQENNWFQIREKTGLLYLSRRLDREDFNML....SV...GNW-ISLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLMNATA......................................................
A0A1S3N2X8_SALSA/26-140             ...LYFPQNQYKETVYV.....GQSAGTPVLQVHAMVESDSQRPH...FYLCYL--..---RPPTYAPWFHLDETTGILSMNKTLEWSDFDSA....Y-...KFW-----KLPLSVIAATRPLKKFLCgLSHPT....VQVSLTFINDTA......................................................
A0A091IUX9_CALAN/5-128              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGEVPY...FHLCQNLV..ISRARSHENHWFQIREKTGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVVLSLINATA......................................................
A0A1S3RRC1_SALSA/26-141             ...LYFPQNHYKEAVYV.....GQYAGTPVLQVHAMVESDSQQPH...FYLCWN--..NPQKPPTYAPWFHLDETTGILSMNKTLEWSDFDNK....Y-...KIW-----ILPLTVMAATRPVKSFLC.-GLLT....VRVSLSFINNTV......................................................
G3HKS9_CRIGR/9-134                  ...LYFSRDAYWERLYV.....DQPANTPLLYVHALRDAPEEVPS...FRLGQHLY.sAYRTRLHENDWIRIHEDTGLLYLNQSLDHSSWEQL....SI...RNGGFPLLTIFLQVFLGSTAQREGEC.HWPGC....ARVYFSFINDTF......................................................
G3NG57_GASAC/26-144                 ...LYFPQNEYTETVYV.....GQLAGTPILQVHAMLDSDSERSH...FYLCWT--..NPLRRPAYSSWFNLDINTGTLSLNKTLEESDFASL....Q-...HSW--SVKKLFLLAMVIPTFTRKSQC.-IRNS....PRITLDFVNATM......................................................
G1MES8_AILME/33-159                 ...LYFSRDAYWEKLYV.....DQPAGMPLLYVHALRDVPEEVPS...FRLGQHLYgiAYRARLHENDWIRIEEDTGLLYLNRSLDHSTWEKL....SI...RNGGFPVLTIYLQVFLSSASLREGEC.QWPGC....ARVYFSFVNTS-f.....................................................
W5P1A8_SHEEP/41-166                 ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDVPEEVPS...FRLGQHLY.gAYRTRLHENDWVRIQEDTGLLYLNQSLDHSSWEKL....NI...RNGGFPLLTVYLRVFLSPASLREAEC.QWPGC....ARVYFSVINAS-f.....................................................
I3LYN9_ICTTR/27-152                 ...LYFSRDAYWERLYV.....DQPAGTPLLYVHALRDAPGEVPS...FHLGQHLH.gFHRPRLHENNWIRVQEDTGLVYLNQSLDHTSWEKL....SI...RNGGFPLLTIFLQVFLSSTPLRESEC.QWPGC....ARVYFSFYNTS-f.....................................................
Q9BTX6_HUMAN/29-154                 ...LYFSRDAYWEKLYV.....DQAAGTPLLYVHALRDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKL....SV...RNRGFPLLTVYLKVFLSPTSLREGEC.QWPGC....ARVYFSFFNTS-f.....................................................
A0A226NKL3_CALSU/25-148             ...LYFPRKEYSENVYI.....DQPAGTPLLHIHALRDSHGETAH...FHLCQNII..VSRARSHENHWFQIREKMGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
A0A1W2PPN7_HUMAN/1-102              ..x-----DAYWEKLYV.....DQAAGTPLLYVHALRDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKL....SV...RNVADAPT------------------.-----....------------dltslcrprlspahr.......................................
A0A093CL96_TAUER/5-128              ...LYFPRKEYLENVYM.....DQPAGTPLLRIHALRDSHGEAAH...FHLCQNLI..ISRARSHENHWFQIREKTGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
F7DU26_XENTR/11-134                 ...LYFLTKDYDENLYV.....DQPAGTLLLHIHVMKDSPHETPH...FRLCPNSY..LSRISF--YHWFWIDEHTGILYLNRSLDRSDYEVF...dAA...QGSSLAVQKIILKVSTKPQPFLDNNC.DNAPF....TRVHLTFRNIT-s.....................................................
A0A091Q7W3_LEPDC/5-128              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGEVAH...FHLCQNLI..ISRARSHENHWFQIREKTGLLYLSKHLDREDFNVL....SV...GNW-MSLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFVSLINATA......................................................
G1PWX2_MYOLU/9-134                  ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDAPDEVPS...FRLGQHLY.gAYRKRLHENDWIRIQEDTGLLYLNWSLNHSSWEKL....NI...RNGGFPQLTVYLQVFLLPTPLREGEC.QWPGC....ARIYFSFINAS-f.....................................................
A0A218UTR5_9PASE/20-142             ...LYFPRKEYLENVYI.....EEPAGMPLLRIHALRDSHEEVAH...FHLCQHLI..VPRARPQENNWFQIREKTGLLYLSKSLDREDFNML....SV...GSW-MPLSKVMLYVSVS-HPFQEKDC.DSATR....TTVFLSLINATA......................................................
H2V9H7_TAKRU/20-141                 ...LYFSQNEYIETVYV.....GQPAGTPVLQVHAMRDGDTERPH...FYLCSM--..NSRRRPAHVSWFRLDISTGVLSLNKTLEESDFASF....FI...CRY-DSVKKLSMHVMALPGFTKNSLC.NSRSC....PRINLEFVNATM......................................................
A0A1S3H9Z7_LINUN/26-157             ...LYFTQDNYQEEIST.....DFEAGRNIIKVYALLENEKYRKSngtIYQIQSTL..KCGQRIEEGSVFHINRSTGWISLTKSLEPV-----....--...--------------------------.-----....------------saidhercflltvlatsgnesdvttvritvistnrkppcniaktedvericfrn
V8P465_OPHHA/30-142                 ...LYFPRKTYHENVYL.....EQPEGTPLLQLHALKDSEEEEAF...YCLVPD--..SFGTGS-KNLWFQISERTGLLYLNKSLDTS-----....--...---GSPVAKVILRVFLSSKPFQAKNClGSASM....TVVKLSVLNATM......................................................
A8E7C6_DANRE/23-140                 ...LYFPQRLYTENIYV.....GQQQGSPLLQVISMREFPTERPY...FFLCSH--..----RDAFTSWFHIDEASGVLYLNKTLEWSDFSSL....RS...GSV-RSPKDLTLKVGVSSTPPMKVMC.TILPT....VEVKLSFINDTA......................................................
A0A091F9U6_CORBR/4-127              ...LYFPRKEYLENVYI.....DEPAGLPLLRIHALKDSHEEVAH...FHLCQNLI..ISRARSHENNWFQIREKKGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
G1T0Q2_RABIT/29-154                 ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDAPGEVAS...FRLGQHLY.gAYRTRLHENEWIRIHEDTGLLYLNRSLDQSTWEKL....SL...RNGGFPLLTIFLQVFLSPVSLREAEC.QWPGC....ARVYFSCINSS-f.....................................................
L5KWJ8_PTEAL/3-128                  ...LYFSRDAYWEKLYV.....DQPAGMPLLYVHALRDVPEEVPS...FRLGQYLY.sAYRTRLNENDWIRIQEDTGLLYLNWSLDHSSWEKL....SV...RNGGFPLLTVYLQVFLSPTYLREGEC.QWPGC....ARVYFSFINTS-f.....................................................
G3UR22_MELGA/15-138                 ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGESAH...FHLCQNLI..ISRARSHENHWFQIREKMGLLYLSKSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVVLSLINATA......................................................
G5BD17_HETGA/1-95                   ..m--------------.....-----------------PGEVPR...FHVGQHLY.gVYHKPLHKNDWIRV-EDTGLLYLNRSLDRDSWEQL....SL...RNGGFPLLTIFLHVFLSYPPLREGEC.HWPGC....TRVYFSFINTS-f.....................................................
H0X4E9_OTOGA/14-139                 ...LYFSRDVYWEKLYV.....DQPAGMPLLYVHALQDTPGEVPS...FRLRPYFY.sVSRHRLHKNDWIRIQEDTGLLYLNRSLDHSSWEKL....NH...LNGGYPLLTIHLQVFLSPTSLRESEC.QWPGC....VRVYFSFINAS-f.....................................................
A0A087R166_APTFO/5-128              ...LYFPRKEYLENVYI.....DQPAGTPLLRIHALRDSHGEVAH...FHLCQNLI..VSRARSHENNWFQIREKTGLLYLSKSLDREDFNVL....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSASR....TTVFLSLINATA......................................................
A0A091S7L4_9GRUI/5-128              ...LYFPRKEYSENVYI.....DQPAGTPLLRIHALRDSHGEVAH...FHLCQNLI..ISRARSHENHWFQMRENTGLLYLSRSLDREDFNML....SV...GNW-MPLSKVMLYVFLSSHPFQEKEC.DSATR....TTVFLSLINATA......................................................
H1A1E9_TAEGU/5-127                  ...LYFPRKEYLENVYI.....DEPAGMPLLRIHALRDSHEEVAH...FHLCQHLI..VPRARPQENNWFQIREKTGLLYLSRSLDREDFNML....SV...GSW-MPLSKVMLYVSVS-HPFQEKDC.DSATR....TTVFLSLINATA......................................................
F6S7W7_MACMU/30-155                 ...LYFSRDAYWEKLYV.....DQPAGTPLLYVHALRDAPEEVPS...FRLGQHLY.gTYRTRLHENNWICIQEDTGLLYLNRSLDRSSWEKL....SG...RNRGFPLLTVYLKVFLSPTSLREGEC.QWPGC....ARVYFSFFNTS-f.....................................................
#=GC SS_cons                        ...-EES-SEEEEEEET.....TB-TT-EEEE--EE-SSTT----...-EE-SEEE.-GGG-EEEE--SEEE-TTT-EEEESS-B-HHHHHHH....HH...TSTTS---EEEEEEES----------.-TTTE....EEEEEEEESS---.....................................................
#=GC seq_cons                       ...LYFsRctY.EplYl.....DQPAGTPLLhlHALRDu.sEVsp...F+LsQpLh..h.RsR.HENsWFpIcEcTGLLYLN+SLD+psaphL....Sl...tNh.hPL.pVhLhVFLSspshpEtEC.p.ssp....spValShINuT.......................................................
//
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