GenomeNet

Database: Pfam
Entry: RTX_C
LinkDB: RTX_C
Original site: RTX_C 
#=GF ID   RTX_C
#=GF AC   PF08339.11
#=GF DE   RTX C-terminal domain
#=GF AU   Fenech M;0000-0001-7933-4617
#=GF SE   Pfam-B_2178 (release 18.0)
#=GF GA   30.20 30.20;
#=GF TC   30.20 43.70;
#=GF NC   30.00 29.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   8800842
#=GF RT   Biological effects of RTX toxins: the possible role of
#=GF RT   lipopolysaccharide. 
#=GF RA   Czuprynski CJ, Welch RA; 
#=GF RL   Trends Microbiol 1995;3:480-483.
#=GF DR   INTERPRO; IPR013550;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family describes the C-terminal region of various bacterial
#=GF CC   haemolysins and leukotoxins, which belong to the RTX family of
#=GF CC   toxins. These are produced by various Gram negative bacteria,
#=GF CC   such as E. coli (Swiss:P09983) and Actinobacillus
#=GF CC   pleuropneumoniae (Swiss:P15377). RTX toxins may interact with
#=GF CC   lipopolysaccharide (LPS) to functionally impair and eventually
#=GF CC   kill leukocytes [1]. This region is found in association with
#=GF CC   the RTX N-terminal domain (Pfam:PF02382) and multiple
#=GF CC   hemolysin-type calcium-binding repeats (Pfam:PF00353).
#=GF SQ   8
#=GS A0A380TL94_9PAST/810-940   AC A0A380TL94.1
#=GS W0Q9Z2_9PAST/807-938       AC W0Q9Z2.1
#=GS A0A380TW60_9PAST/885-1007  AC A0A380TW60.1
#=GS M4RAK6_BIBTR/809-940       AC M4RAK6.1
#=GS F5S905_9NEIS/813-944       AC F5S905.1
#=GS A0A066UM22_9GAMM/784-916   AC A0A066UM22.1
#=GS A0A238HI88_9NEIS/824-955   AC A0A238HI88.1
#=GS Q46716_ECO57/854-998       AC Q46716.2
A0A380TL94_9PAST/810-940              .AFSDVNLKDLTFKKVDSSLEII-..........NQKGEKVRIGNWFLeddlASTVANYKATN-DRKIEEII.GKGGERITSEQVDKLI..-KEGNN.QISAEALSKVVN.DYNTSKDRQNVSNSLAKLISSVGSFTS..............SSDFRNNL-----gtyv...
W0Q9Z2_9PAST/807-938                  .SFSDSNLKDLTFEKVKYNLVIT-..........NTKKETVTIQNWFReadlAKEVRNYQATK-DEKIEEII.GRNGERITSSQVDDLI..-AKGNG.KIDQNELTKVVD.NYELLKRSRNVTNSLDKLISSVSSFTS..............SNDSRNVLVNPTS.......
A0A380TW60_9PAST/885-1007             y-LSDFSFDRLLVEKVDDNLVLRSn.......esSHNNGVLTIKDWFK....-------EGNKYNHKIEQIV.DKNGRKLTAENLGTYF..KNAP--.--KADNLLNYATkEDQNESNLSSLKTELGKIITNAGNFGVa............kQGN----------tgintaa
M4RAK6_BIBTR/809-940                  .SFSDSNLKDLTFEKVNHHLVIT-..........NTKQEKVTIQNWFReaefAKTIQNYVATR-DDKIEEII.GQNGERITSKQVDELI..-EKGNG.KIAQSELTKVVD.NYQLLKYSRDASNSLDKLISSASAFTS..............SNDSRNVLASPTS.......
F5S905_9NEIS/813-944                  .AFADADLSELTIERTAQGIMIKR..........NDGSGSINMAEWYK....TLSRPNYHGNATDDKIEQII.GKNGDYITSEQIDKLL..KDKQTG.TITSAQLQQLAQeNKSKSIDSGNLASTLNKLIESMASFGS..............RGATASNYLQPAH.......
A0A066UM22_9GAMM/784-916              .AFADANLSELTIERTQEGILIKL..........NDNSGSINVSNWYI....ASKLVNYHGHKTDNKIEHLI.GKDGTYITSEQIDSLL..ENKQVGeKITSQQLQELANkNKSQEISVSDIASSLNKLIGSMALFGT..............ENPVSSNTLQPTT.......
A0A238HI88_9NEIS/824-955              .AFADADLSELTIERTAQGIMIKR..........NDGSGSINMAEWYK....TLSRQNYHGNATDDKIEQII.GKNGDYITSEQIDKLL..KDKQTG.TITSAQLQQLAQeNKSKSIDSGNLASTLNKLIESMASFGS..............RGATASNYLQPAH.......
Q46716_ECO57/854-998                  .HLSDISFDDIAFKRVGNDLIMNKaingvlsfneSNDVNGITFKNWFA....------KDASGADNHLVEVItDKDGREI---KVDKIPhnNNERSG.YIKASNIA----.SEKNMVNITSVANDINKIISSVSGFDSgderlaslynlslhQNNTHSTTLTTTV.......
#=GC seq_cons                         .uFSDusLc-LThE+VspsLlIp...........NssssslslpNWF+....s.ph.NYcusphDcKIEcII.GKNG-cITSEQlDcLl..psKtsG.pIsuspLpplss.NcppphsssslusoLsKLIoSsuuFsS..............pssopsshlpPsp.......
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