GenomeNet

Database: Pfam
Entry: RXLR_WY
LinkDB: RXLR_WY
Original site: RXLR_WY 
#=GF ID   RXLR_WY
#=GF AC   PF18634.1
#=GF DE   RXLR phytopathogen effector protein WY-domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF07984
#=GF GA   26.20 26.20;
#=GF TC   26.30 26.40;
#=GF NC   26.00 25.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   27458016
#=GF RT   Structural Basis of Host Autophagy-related Protein 8 (ATG8)
#=GF RT   Binding by the Irish  Potato Famine Pathogen Effector Protein
#=GF RT   PexRD54.
#=GF RA   Maqbool A, Hughes RK, Dagdas YF, Tregidgo N, Zess E, Belhaj K,
#=GF RA   Round A, Bozkurt TO, Kamoun S, Banfield MJ;
#=GF RL   J Biol Chem. 2016;291:20270-20282.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Filamentous plant pathogens cause devastating diseases of crops.
#=GF CC   Phytophthora infestans, the Irish potato famine pathogen,
#=GF CC   facilitates disease on its hosts by delivering effector proteins
#=GF CC   that modulate host cell processes to the benefit of the
#=GF CC   parasite, a strategy used by many biotrophic plant pathogens.
#=GF CC   The Phytophthora infestans RXLR-type effector PexRD54 binds
#=GF CC   potato ATG8 via its ATG8 family-interacting motif (AIM) and
#=GF CC   perturbs host-selective autophagy. The N-terminal region of
#=GF CC   PexRD54 contains 5 tandem WY domains. The WY domain is a
#=GF CC   conserved structural unit consisting of three alpha-helices and
#=GF CC   two characteristic hydrophobic amino acids, frequently W (Trp)
#=GF CC   and Y (Tyr), which contribute to a stable hydrophobic core.
#=GF CC   Deletion analysis show that the WY domains of PexRD54 are
#=GF CC   dispensable for ATG8CL binding suggesting an alternative
#=GF CC   function for these domains [1].
#=GF SQ   68
#=GS A0A225UFG3_9STRA/81-125   AC A0A225UFG3.1
#=GS V9FXF0_PHYPR/99-146       AC V9FXF0.1
#=GS A0A225WUY7_9STRA/58-100   AC A0A225WUY7.1
#=GS W2L0H9_PHYPR/122-170      AC W2L0H9.1
#=GS A0A225UUW5_9STRA/114-160  AC A0A225UUW5.1
#=GS D0NBE6_PHYIT/151-198      AC D0NBE6.1
#=GS D0NBE6_PHYIT/151-198      DR PDB; 5L7S A; 151-198;
#=GS V9EQF5_PHYPR/133-180      AC V9EQF5.1
#=GS G4ZAZ4_PHYSP/141-187      AC G4ZAZ4.1
#=GS D0N4Y1_PHYIT/251-298      AC D0N4Y1.1
#=GS D0N0F7_PHYIT/137-183      AC D0N0F7.1
#=GS A0A225VIS1_9STRA/51-97    AC A0A225VIS1.1
#=GS G5A456_PHYSP/143-188      AC G5A456.1
#=GS A0A0W8CZL9_PHYNI/17-64    AC A0A0W8CZL9.1
#=GS A0A225VSB8_9STRA/109-156  AC A0A225VSB8.1
#=GS A0A0W8B9A7_PHYNI/151-198  AC A0A0W8B9A7.1
#=GS A0A225VLX7_9STRA/125-181  AC A0A225VLX7.1
#=GS A0A0W8DZ98_PHYNI/143-190  AC A0A0W8DZ98.1
#=GS A0A0W8BLG4_PHYNI/129-177  AC A0A0W8BLG4.1
#=GS W2R705_PHYPN/151-198      AC W2R705.1
#=GS G4Z977_PHYSP/76-120       AC G4Z977.1
#=GS W2M0R0_PHYPR/30-77        AC W2M0R0.1
#=GS A0A225VE91_9STRA/65-109   AC A0A225VE91.1
#=GS G4ZA51_PHYSP/155-201      AC G4ZA51.1
#=GS V9E690_PHYPR/231-276      AC V9E690.1
#=GS A0A225WDN9_9STRA/134-181  AC A0A225WDN9.1
#=GS D0MUA9_PHYIT/144-188      AC D0MUA9.1
#=GS W2K5I3_PHYPR/45-91        AC W2K5I3.1
#=GS V9EQG9_PHYPR/151-198      AC V9EQG9.1
#=GS W2RJQ2_PHYPN/30-77        AC W2RJQ2.1
#=GS A0A225WRH2_9STRA/136-182  AC A0A225WRH2.1
#=GS G4YGP8_PHYSP/139-181      AC G4YGP8.1
#=GS D0N5N1_PHYIT/239-284      AC D0N5N1.1
#=GS W2Q3F0_PHYPN/122-170      AC W2Q3F0.1
#=GS A0A0W8CPY6_PHYNI/56-103   AC A0A0W8CPY6.1
#=GS W2QUE9_PHYPN/46-91        AC W2QUE9.1
#=GS D0N5N1_PHYIT/140-187      AC D0N5N1.1
#=GS A0A225VKC3_9STRA/140-186  AC A0A225VKC3.1
#=GS G4ZA47_PHYSP/106-153      AC G4ZA47.1
#=GS A0A225V0Y2_9STRA/121-166  AC A0A225V0Y2.1
#=GS W2PWV4_PHYPN/133-180      AC W2PWV4.1
#=GS A0A0W8C2L3_PHYNI/139-184  AC A0A0W8C2L3.1
#=GS W2KST2_PHYPR/151-198      AC W2KST2.1
#=GS W2R650_PHYPN/143-190      AC W2R650.1
#=GS D0NSH8_PHYIT/139-184      AC D0NSH8.1
#=GS G4ZAZ1_PHYSP/134-181      AC G4ZAZ1.1
#=GS G4ZLP0_PHYSP/128-173      AC G4ZLP0.1
#=GS A0A0W8CIW7_PHYNI/108-156  AC A0A0W8CIW7.1
#=GS A0A225WFH1_9STRA/134-179  AC A0A225WFH1.1
#=GS D0NSH6_PHYIT/134-181      AC D0NSH6.1
#=GS G4ZA46_PHYSP/59-106       AC G4ZA46.1
#=GS V9F0J8_PHYPR/122-170      AC V9F0J8.1
#=GS W2R5J3_PHYPN/132-179      AC W2R5J3.1
#=GS A0A0W8CCZ7_PHYNI/152-197  AC A0A0W8CCZ7.1
#=GS V9E0K5_PHYPR/45-91        AC V9E0K5.1
#=GS D0NSH7_PHYIT/134-180      AC D0NSH7.1
#=GS W2MEA6_PHYPR/231-276      AC W2MEA6.1
#=GS W2KTG5_PHYPR/17-64        AC W2KTG5.1
#=GS D0N4Y1_PHYIT/153-200      AC D0N4Y1.1
#=GS W2KT65_PHYPR/143-190      AC W2KT65.1
#=GS D0NWK8_PHYIT/153-200      AC D0NWK8.1
#=GS A0A225VDE2_9STRA/134-179  AC A0A225VDE2.1
#=GS V9ER92_PHYPR/143-190      AC V9ER92.1
#=GS A0A225ULX0_9STRA/134-181  AC A0A225ULX0.1
#=GS V9EQG9_PHYPR/249-296      AC V9EQG9.1
#=GS G4ZLN9_PHYSP/41-86        AC G4ZLN9.1
#=GS W2KR11_PHYPR/56-103       AC W2KR11.1
#=GS A0A225UTQ3_9STRA/128-175  AC A0A225UTQ3.1
#=GS A0A225VEL5_9STRA/86-132   AC A0A225VEL5.1
A0A225UFG3_9STRA/81-125              .....i--KFSDNDIYQ.LLS..KN.TDNSELVVLFYSLKNNESFKSLSESMAK----vv.........
V9FXF0_PHYPR/99-146                  ......DRAFSDLQIYH.LLL..KT.HSAQEVTTLLETAKTTPGLKKIATSVQKSLSG...........
A0A225WUY7_9STRA/58-100              ....ef--AFSDVKLLE.LLE..KK.MSEAELTKLFVSLTKVPGLENLAQSM------i..........
W2L0H9_PHYPR/122-170                 ......ETAFTERELFS.LLR..QSkRTEEELVALSQSLRQVPGMKNIADEMQTYMIL...........
A0A225UUW5_9STRA/114-160             .....l-RWFDDDKIFK.LLQ..KS.KSEDDLVTLFHNLRQVPELKNLADKMQRML--w..........
D0NBE6_PHYIT/151-198                 ......NQAFSDLDIYY.LLL..KT.NSPEQLKLLFETLRHTPGMTKIGASMEKSLSG...........
#=GR D0NBE6_PHYIT/151-198      SS    ......GGGG-HHHHHH.HHH..TT.S-HHHHHHHHHHHHTSTTTHHHHHHHHHHTS-...........
V9EQF5_PHYPR/133-180                 ......ESWFADYKLVE.LLR..KS.KSDAELVTLFQSLRRYSAVKNLADEMQAYMIL...........
G4ZAZ4_PHYSP/141-187                 .....r--SFSDEKIIH.LLL..KF.QSEARLVSLSLSLREIPARKNLADLMQFYL--ve.........
D0N4Y1_PHYIT/251-298                 ......NHWFGDDDMLD.LFR..KT.MPEKDVVTLLHLLRNVPGMKDHGDTMQRFL--fl.........
D0N0F7_PHYIT/137-183                 .....g--WFSDGKLFD.LLR..KT.KPEAELVTLFQSLRGYPNFKDIADKMQSNMIL...........
A0A225VIS1_9STRA/51-97               ...kry---YDDYQMLD.LFR..KV.MPEESVVTLLHSLRQVPGMKNQADTM------lrklf......
G5A456_PHYSP/143-188                 ....gs---FPDYEIYH.LLR..SK.VPEEKLALALESLKQIPDVKNLAETVQNY---ql.........
A0A0W8CZL9_PHYNI/17-64               ......ESWFSDNKLFD.LLR..KV.RSEEELVILFQSLRKYPAIKNLADEMQAYMIL...........
A0A225VSB8_9STRA/109-156             .....q-SAFTDLDLYS.ILR..KT.TSREELVKVFQSLEDVPDLKTLAISIQKSMSG...........
A0A0W8B9A7_PHYNI/151-198             ......EQAFSDLDIYY.LLL..KT.KSAEELSNLLESLQKVPAFKKLAASMQKSLSG...........
A0A225VLX7_9STRA/125-181             .....l-SWFNDVEIVE.LLR..KS.QSDNDLVTLFHNLRQVPGMKNLADELQGFL--lskspssnqlm
A0A0W8DZ98_PHYNI/143-190             ......KTKFSDLDIYY.LLL..RT.NSAEQLKTLPEALRQTPGLIKMGRSMEKSLSG...........
A0A0W8BLG4_PHYNI/129-177             ......ETAFTERELFS.LLR..QSkRTEEELVALSQSLRQVPGMKNIADEMQTYMIL...........
W2R705_PHYPN/151-198                 ......EQAFSDLDIYY.LLL..KT.KSAEELSNLLESLQKVPAFKKLAASMQKSLSG...........
G4Z977_PHYSP/76-120                  ....hr---FTASDIFYtLLA..SK.RTEEEVAVLFASLKKIPGLKKLAEDLQK----a..........
W2M0R0_PHYPR/30-77                   ......DRAFSDLQIYH.LLL..KT.HSAQEVTTLLETAKTTPGLKKIATSVQKSLSG...........
A0A225VE91_9STRA/65-109              .....v--QFSDDDIYQ.LLS..KN.TDNGELAVLFYSLKSNPAFKSLGESMAK----vv.........
G4ZA51_PHYSP/155-201                 .....r--SFSDHQIVV.LLR..KS.HSDEKLVTLSQSLRRIPARKNLAEMMQRYLI-e..........
V9E690_PHYPR/231-276                 ....ds---FSVFQTNQ.LLL..EH.TSPARLVVRLESIKKTPDLEMLAESMQSQL--l..........
A0A225WDN9_9STRA/134-181             .....q-SAFTDLDLYS.ILR..KT.NSREELVKAFQSLEDVPDLRTLATNMQKSMSG...........
D0MUA9_PHYIT/144-188                 .....k-EAFSDLAIYY.LLL..KT.NSEEEVTTLIQSLKNTPGLKKIGASIR-----er.........
W2K5I3_PHYPR/45-91                   ..lllg-----NKKIYE.LLR..QS.NSEEELATLFHSLRQVSGMENFADEMQIFMIL...........
V9EQG9_PHYPR/151-198                 ......EQAFSDLDIYY.LLL..KT.KSAEELSNLLESLQKVPAFKKLAASMQKSLSG...........
W2RJQ2_PHYPN/30-77                   ......DRAFSDLQIYH.LLL..KT.HSAQEVTTLLETAKTTPGLKKIATSVQKSLSG...........
A0A225WRH2_9STRA/136-182             .....k-RDFSDYNMYM.VLK..QS.NSEEKLVELFHSMRRYPEMKDLANTLQMKM--y..........
G4YGP8_PHYSP/139-181                 .....p-----NYDIYT.LLR..SK.VPEDKLAITFESLKQIPDVRNLAETMQNY---ql.........
D0N5N1_PHYIT/239-284                 ....vm---FGDIDMFS.LLQ..KT.MPERELTTLFYSLRKVPNMKNNAETMQRFM--l..........
W2Q3F0_PHYPN/122-170                 ......ETAFTERELFS.LLR..QSkRTEEELVALSQSLRQVPGMKNIADEMQTYMIL...........
A0A0W8CPY6_PHYNI/56-103              ......ESWFADYKLVE.LLR..KS.KSDAELVTLFQSLRRYPAVKNLADEMQAYMIL...........
W2QUE9_PHYPN/46-91                   ...llg-----NKKIYE.LLR..QS.NSEEELATLFHSLRQVSGMENFADEMQIFMIL...........
D0N5N1_PHYIT/140-187                 ......EKAILNLDVYY.LLL..ET.HSNQELMTLLKSLKKTPGLSKFASNIQESLSG...........
A0A225VKC3_9STRA/140-186             ....ny---FYDVEMYQ.LLR..KS.QSDDDLVTLFHNLRQVPEMKNLADKMQRIMLG...........
G4ZA47_PHYSP/106-153                 ......KRWFTDLEVFN.FLR..QT.TPGAELAAVLQSIRLVPGMKKSAEKMQKFLI-r..........
A0A225V0Y2_9STRA/121-166             .....k--SFYDEEIVD.LLR..NS.KSDDELVTLFHNLRQVPEMKNLADKLQRTL--l..........
W2PWV4_PHYPN/133-180                 ......ESWFADYKLVE.LLR..KS.KSDAELVTLFQSLRRYSAVKNLADEMQAYMIL...........
A0A0W8C2L3_PHYNI/139-184             ...llg-----NKKIYE.LLR..QS.NSEEELATLFHSLRQVSGMENFADEMQIFMIL...........
W2KST2_PHYPR/151-198                 ......EQAFSDLDIYY.LLL..KT.KSAEELSNLLESLQKVPAFKKLAASMQKSLSG...........
W2R650_PHYPN/143-190                 ......KTKFSDLDIYY.LLL..RT.NSAEQLKTLPEALRQTPGLIKMGKSMEKSLSG...........
D0NSH8_PHYIT/139-184                 fygddv--------LLD.LLR..KT.KSEEELVRLFQSLRQNPAFKDIAEKMKI----dmvl.......
G4ZAZ1_PHYSP/134-181                 ....yr--SYSNNQVFD.LLR..LS.NSDEELVTLFLSLRRASGMREFADEMQRYL--fl.........
G4ZLP0_PHYSP/128-173                 ....ad--SFTDYQIYK.LLS..RE.VPDEKLALVFESLKQIDDLKSLGETMQKY---q..........
A0A0W8CIW7_PHYNI/108-156             ......ETAFTERELFS.LLR..QSkRTEEELVALSQSLRQVPGMKNIADEMQTYMIL...........
A0A225WFH1_9STRA/134-179             .....a-KEFPDDEIYA.LLK..PI.QTESQLATLFRSMKSIPDLKNMGESMQMY---q..........
D0NSH6_PHYIT/134-181                 ....ka--SFSDDKLFD.LVR..KL.NSEEELVSLFQSLRHYPDIKNIADDMQAYLIL...........
G4ZA46_PHYSP/59-106                  ......NHWFSDGDVFE.ILA..KT.TPQADLAVIFQALRAVPGMKNAATILQQYL--fa.........
V9F0J8_PHYPR/122-170                 ......ETAFTERELFS.LLR..QSkRTEEELVALSQSLRQVPGMKNIADEMQTYMIL...........
W2R5J3_PHYPN/132-179                 ......ESWFSDNKLFD.LLR..KV.RSEEELVILFQSLRKYPAIKNLADEMQAYMIL...........
A0A0W8CCZ7_PHYNI/152-197             ....ds---FSVFQTNQ.LLL..EH.TSPARLVVRLESIKKTPDLEMLAESMQSQL--l..........
V9E0K5_PHYPR/45-91                   ..lllg-----NKKIYE.LLR..QS.NSEEELATLFHSLRQVSGMENFADEMQIFMIL...........
D0NSH7_PHYIT/134-180                 ....vk---FGEDELLS.LLM..KT.RAEEELVSLFQSLRQYPDITKMASDMQASMIL...........
W2MEA6_PHYPR/231-276                 ....ds---FSVFQTNQ.LLL..EH.TSPARLVVRLESIKKTPDLEMLAESMQSQL--l..........
W2KTG5_PHYPR/17-64                   ......ESWFSDNKLFD.LLR..KV.RSEEELVILFQSLRKYPAIKNLADEMQAYMIL...........
D0N4Y1_PHYIT/153-200                 ......NQAFSDLDLYY.LLL..KR.SSGEELKILIESFRKTGALKELGKSMQKSLSG...........
W2KT65_PHYPR/143-190                 ......KTKFSDLDIYY.LLL..RT.NSAEQLKTLPEALRQTPGLIKMGRSMEKSLSG...........
D0NWK8_PHYIT/153-200                 ......NQAFSDLDLYY.LLL..KR.NSAEELKILFESFLKTEGLKDLGKSMQNSLSG...........
A0A225VDE2_9STRA/134-179             ....vk--EFPDAEMYA.LLK..PI.QTESQLATLFQSMKSIPDLKNMGETMQMY---q..........
V9ER92_PHYPR/143-190                 ......KTKFSDLDIYY.LLL..RT.NSAEQLKTLPEALRQTPGLIKMGKSMEKSLSG...........
A0A225ULX0_9STRA/134-181             ....ak--GISDGEIYA.LLKpiQI.QRESQLATLFQSMKSIPDLKNMGETMQMY---q..........
V9EQG9_PHYPR/249-296                 ......DHWFGDIEMLA.LFR..KT.MPEDEVVLLIHKIRNIPGMKNHGDTMQRFL--fl.........
G4ZLN9_PHYSP/41-86                   ....gs---FTDYQIYR.LLS..TK.VPEEKLALVFESLKQIPDLKSLAETMQNY---qi.........
W2KR11_PHYPR/56-103                  ......ESWFADYKLVE.LLR..KS.KSDAELVTLFQSLRRYPAVKNLADEMQAYMIL...........
A0A225UTQ3_9STRA/128-175             ......DHWFTDEQIIN.LLR..NS.KPETELVSFFQSLRQIPDMETFADALQRSMV-l..........
A0A225VEL5_9STRA/86-132              .....e-DYFSDYGLFK.LLK..DS.RPETELLTVLQSMKRIPDMKTRAESMQLYL--f..........
#=GC SS_cons                         ......GGGG-HHHHHH.HHH..TT.S-HHHHHHHHHHHHTSTTTHHHHHHHHHHTS-...........
#=GC seq_cons                        ........hFoDhclap.LLp..+o.pS--ELssLhpSLRpsPuhKslA-sMQp.h.............
//
DBGET integrated database retrieval system