GenomeNet

Database: Pfam
Entry: Radical_SAM
LinkDB: Radical_SAM
Original site: Radical_SAM 
#=GF ID   Radical_SAM
#=GF AC   PF04055.21
#=GF DE   Radical SAM superfamily
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Bateman A
#=GF GA   29.50 29.50;
#=GF TC   29.50 29.50;
#=GF NC   29.40 29.40;
#=GF BM   hmmbuild  --handHMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Radical_SAM
#=GF NE   PF00037;
#=GF NL   O26445.1/48-76
#=GF RN   [1]
#=GF RM   11222759
#=GF RT   Radical SAM, a novel protein superfamily linking unresolved
#=GF RT   steps in familiar biosynthetic pathways with radical mechanisms:
#=GF RT   functional characterization using new analysis and information
#=GF RT   visualization methods. 
#=GF RA   Sofia HJ, Chen G, Hetzler BG, Reyes-Spindola JF, Miller NE; 
#=GF RL   Nucleic Acids Res 2001;29:1097-1106.
#=GF RN   [2]
#=GF RM   17335281
#=GF RT   Anaerobic sulfatase-maturating enzymes: radical SAM enzymes able
#=GF RT   to catalyze in vitro sulfatase post-translational modification. 
#=GF RA   Benjdia A, Leprince J, Guillot A, Vaudry H, Rabot S, Berteau O; 
#=GF RL   J Am Chem Soc. 2007;129:3462-3463.
#=GF RN   [3]
#=GF RM   16766528
#=GF RT   A new type of bacterial sulfatase reveals a novel maturation
#=GF RT   pathway in prokaryotes. 
#=GF RA   Berteau O, Guillot A, Benjdia A, Rabot S; 
#=GF RL   J Biol Chem. 2006;281:22464-22470.
#=GF DR   INTERPRO; IPR007197;
#=GF DR   SCOP; 1olt; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Radical SAM proteins catalyse diverse reactions, including
#=GF CC   unusual methylations, isomerisation, sulphur insertion, ring
#=GF CC   formation, anaerobic oxidation and protein radical formation.
#=GF SQ   122015
#=GS A0A245ZUJ4_9SPHN/10-181     AC A0A245ZUJ4.1
#=GS A0A069ICN2_9BURK/19-176     AC A0A069ICN2.1
#=GS A0A1C4W1X2_MICEC/23-173     AC A0A1C4W1X2.1
#=GS Q0IBC3_SYNS3/66-238         AC Q0IBC3.1
#=GS TYW1_YEAST/473-657          AC Q08960.1
#=GS A9A0S1_DESOH/231-397        AC A9A0S1.1
#=GS D3NQH6_AZOS1/19-190         AC D3NQH6.1
#=GS A0A0A3IS89_9BACI/123-296    AC A0A0A3IS89.1
#=GS Q8TWY5_METKA/122-278        AC Q8TWY5.1
#=GS A0A127APZ8_9DELT/149-321    AC A0A127APZ8.1
#=GS A0A0Q5YRK0_9BRAD/61-202     AC A0A0Q5YRK0.1
#=GS A0A179HXK9_9HYPO/641-800    AC A0A179HXK9.1
#=GS A9D590_9GAMM/64-232         AC A9D590.1
#=GS A0A1G0ZMN8_9BACT/169-338    AC A0A1G0ZMN8.1
#=GS H2YWM4_CIOSA/262-444        AC H2YWM4.1
#=GS K0UJU2_MYCVA/62-223         AC K0UJU2.1
#=GS A0A0D5LP30_9RHIZ/28-191     AC A0A0D5LP30.1
#=GS D3F5N1_CONWI/429-603        AC D3F5N1.1
#=GS A0A142XEN4_9BACT/30-182     AC A0A142XEN4.1
#=GS A0A0K9GY97_9BACI/42-215     AC A0A0K9GY97.1
#=GS A0A2K5KIN1_CERAT/3-149      AC A0A2K5KIN1.1
#=GS A0A1I1GWP2_9GAMM/61-237     AC A0A1I1GWP2.1
#=GS A0A1W2BBM4_9FIRM/33-264     AC A0A1W2BBM4.1
#=GS S3C708_OPHP1/117-325        AC S3C708.1
#=GS A0A179D441_9BACT/20-189     AC A0A179D441.1
#=GS A0A2H3EXI2_9HELO/27-199     AC A0A2H3EXI2.1
#=GS A0A0N0CWU6_9BACI/112-283    AC A0A0N0CWU6.1
#=GS A0A1F5B188_9BACT/93-250     AC A0A1F5B188.1
#=GS A0A1M7F7D8_9FLAO/48-209     AC A0A1M7F7D8.1
#=GS A0A1G1STD9_9BACT/116-289    AC A0A1G1STD9.1
#=GS A0A1V1W228_9ACTN/127-304    AC A0A1V1W228.1
#=GS T0LDD4_9EURY/52-212         AC T0LDD4.1
#=GS A0A1M5XJ51_9FIRM/104-264    AC A0A1M5XJ51.1
#=GS A0A095TDX5_9GAMM/10-181     AC A0A095TDX5.1
#=GS A0A1H9ET93_9SPIO/143-313    AC A0A1H9ET93.1
#=GS A0A177NJG7_9GAMM/27-123     AC A0A177NJG7.1
#=GS A0A239CCI2_9BURK/91-255     AC A0A239CCI2.1
#=GS A0A1I5QCH2_9BRAD/27-151     AC A0A1I5QCH2.1
#=GS S7UK54_DESML/235-394        AC S7UK54.1
#=GS A0A1M5FSS0_9BACT/12-163     AC A0A1M5FSS0.1
#=GS A0A0N5AGH4_9BILA/125-290    AC A0A0N5AGH4.1
#=GS X6KWT9_9RHOB/54-228         AC X6KWT9.2
#=GS A0A250ICM8_9DELT/198-396    AC A0A250ICM8.1
#=GS L9WFY3_9EURY/15-175         AC L9WFY3.1
#=GS A0A1Q3THH1_9SPHI/58-231     AC A0A1Q3THH1.1
#=GS A0A2B4R3K8_STYPI/154-328    AC A0A2B4R3K8.1
#=GS A0A178B6E6_9PLEO/96-263     AC A0A178B6E6.1
#=GS A0A0F8XNL9_9ARCH/78-256     AC A0A0F8XNL9.1
#=GS A0A037Z8Q0_CLOTT/62-222     AC A0A037Z8Q0.1
#=GS A0A0A2T8R8_9BACI/21-187     AC A0A0A2T8R8.1
#=GS MOAA_ALKOO/14-176           AC A8MLW5.1
#=GS A0A1G6E2Q5_9DELT/324-527    AC A0A1G6E2Q5.1
#=GS A0A0U1M0R2_TALIS/116-324    AC A0A0U1M0R2.1
#=GS A0A1F4K2E5_9BURK/82-247     AC A0A1F4K2E5.1
#=GS A0A2G1VBD3_9ALTE/110-325    AC A0A2G1VBD3.1
#=GS RLMN_PROM0/107-281          AC A3PEX0.1
#=GS U2PTH2_9CLOT/177-340        AC U2PTH2.1
#=GS A0A0E3NQY9_9EURY/64-234     AC A0A0E3NQY9.1
#=GS A0A0E9ZVR3_9FLAO/13-182     AC A0A0E9ZVR3.1
#=GS MOAA_ALKMQ/14-176           AC A6TVF9.1
#=GS E4Q177_CALOW/146-318        AC E4Q177.1
#=GS A0A1H7VGP6_9BACT/4-144      AC A0A1H7VGP6.1
#=GS A0A1S9B0G2_9BACT/100-263    AC A0A1S9B0G2.1
#=GS A0A0C2ANQ8_9ACTN/194-380    AC A0A0C2ANQ8.1
#=GS A0A1F5TFJ7_9BACT/5-164      AC A0A1F5TFJ7.1
#=GS A0A1I2QMR2_9CORY/6-182      AC A0A1I2QMR2.1
#=GS A0A1G0WD48_9BACT/10-179     AC A0A1G0WD48.1
#=GS A0A256FZA1_9RHIZ/169-343    AC A0A256FZA1.1
#=GS K9S9M7_9CYAN/117-286        AC K9S9M7.1
#=GS A0A0D2J172_9DELT/25-174     AC A0A0D2J172.1
#=GS A0A1I2FCK6_9GAMM/43-206     AC A0A1I2FCK6.1
#=GS A0A1J5J664_9EURY/64-238     AC A0A1J5J664.1
#=GS A0A1M5VQX8_FLAFR/100-263    AC A0A1M5VQX8.1
#=GS A0A084TNF7_9FLAO/147-323    AC A0A084TNF7.1
#=GS C6LGI7_9FIRM/7-178          AC C6LGI7.1
#=GS Q63PB8_BURPS/203-364        AC Q63PB8.1
#=GS M9RQJ3_9RHOB/56-182         AC M9RQJ3.1
#=GS A0A1G8IPC9_9FLAO/64-226     AC A0A1G8IPC9.1
#=GS A0A1D8P8P3_9FLAO/48-209     AC A0A1D8P8P3.1
#=GS A0A1H3HKE6_9BURK/47-218     AC A0A1H3HKE6.1
#=GS A0A143B8E5_9DELT/33-182     AC A0A143B8E5.1
#=GS A0A1H9E4W2_9FIRM/27-209     AC A0A1H9E4W2.1
#=GS K8EIZ2_9FIRM/81-238         AC K8EIZ2.1
#=GS A0A212TTR8_9ACTN/73-248     AC A0A212TTR8.1
#=GS C5A4P1_THEGJ/121-288        AC C5A4P1.1
#=GS A0A1G0WEE4_9BACT/49-209     AC A0A1G0WEE4.1
#=GS A0A101T6V4_9ACTN/79-242     AC A0A101T6V4.1
#=GS M0F018_9EURY/16-175         AC M0F018.1
#=GS D2RHN0_ARCPA/79-285         AC D2RHN0.1
#=GS A0A1G0SKH4_9BACT/15-201     AC A0A1G0SKH4.1
#=GS A0A136WFA7_9FIRM/189-361    AC A0A136WFA7.1
#=GS A0A1M6G812_9BACT/39-211     AC A0A1M6G812.1
#=GS H8FSH7_PHAMO/99-261         AC H8FSH7.1
#=GS D5E7G8_METMS/55-225         AC D5E7G8.1
#=GS A0A0R0E2G6_9GAMM/17-178     AC A0A0R0E2G6.1
#=GS A0A0Q7NPX7_9NOCA/552-726    AC A0A0Q7NPX7.1
#=GS A0A133ZB45_9ACTN/114-287    AC A0A133ZB45.1
#=GS W4P3S9_9BACE/24-188         AC W4P3S9.1
#=GS A0A1E3XBE0_9BACT/117-275    AC A0A1E3XBE0.1
#=GS A0A1S8W3M1_9FUNG/140-313    AC A0A1S8W3M1.1
#=GS K9SUQ7_9SYNE/171-340        AC K9SUQ7.1
#=GS A0A0T1W3J1_9MYCO/558-732    AC A0A0T1W3J1.1
#=GS A0A1V2ICP3_9ACTN/16-179     AC A0A1V2ICP3.1
#=GS A0A0M2U6P9_9FIRM/89-258     AC A0A0M2U6P9.1
#=GS A0A1I2G5D7_9ACTN/523-697    AC A0A1I2G5D7.1
#=GS B0VJ12_CLOAI/118-274        AC B0VJ12.1
#=GS A0A1J4VN25_9BACT/219-383    AC A0A1J4VN25.1
#=GS W8X0F3_CASDE/191-366        AC W8X0F3.1
#=GS A0A174AHT2_CLOVE/37-211     AC A0A174AHT2.1
#=GS M2PZQ6_9FIRM/38-212         AC M2PZQ6.1
#=GS A0A068YQ54_9BURK/477-683    AC A0A068YQ54.1
#=GS A0A1X9YE66_9SPHN/144-323    AC A0A1X9YE66.1
#=GS V7FAN3_9RHIZ/50-224         AC V7FAN3.1
#=GS A0A1E8FGM9_9ALTE/172-351    AC A0A1E8FGM9.1
#=GS A0A1M6DYW0_9FIRM/94-237     AC A0A1M6DYW0.1
#=GS A0A1Y4K423_9ACTN/162-333    AC A0A1Y4K423.1
#=GS A0A0L0DEI2_THETB/117-295    AC A0A0L0DEI2.1
#=GS A0A0G0JTB2_9BACT/161-374    AC A0A0G0JTB2.1
#=GS G0SWE7_RHOT2/673-838        AC G0SWE7.1
#=GS R6EHI1_9FIRM/146-320        AC R6EHI1.1
#=GS A0A0B3W149_9FIRM/21-224     AC A0A0B3W149.1
#=GS A0A1W9P3K4_9BACT/12-151     AC A0A1W9P3K4.1
#=GS A0A0N0N831_9ACTN/268-434    AC A0A0N0N831.1
#=GS M5CP18_STEMA/141-320        AC M5CP18.1
#=GS A0A075R0J6_BRELA/84-254     AC A0A075R0J6.1
#=GS U3CP34_9VIBR/63-237         AC U3CP34.1
#=GS RIMO_THET8/136-315          AC Q5SJ39.1
#=GS K6Z4Z2_9ALTE/50-223         AC K6Z4Z2.1
#=GS MTAB_BACSU/147-319          AC P54462.1
#=GS D3P818_AZOS1/38-210         AC D3P818.1
#=GS A0A1G7PS93_9DELT/29-167     AC A0A1G7PS93.1
#=GS A0A0J1DMN0_9FIRM/152-324    AC A0A0J1DMN0.1
#=GS A0A218Q5J9_9CYAN/226-391    AC A0A218Q5J9.1
#=GS F8ED55_RUNSL/50-224         AC F8ED55.1
#=GS A0A1Y0HJB0_9PROT/46-213     AC A0A1Y0HJB0.1
#=GS A4IKC5_GEOTN/35-206         AC A4IKC5.1
#=GS A0A1S1XZL5_9GAMM/59-243     AC A0A1S1XZL5.1
#=GS A0A0S4L184_9BACT/31-193     AC A0A0S4L184.1
#=GS A0A0J8GY20_9ALTE/15-176     AC A0A0J8GY20.1
#=GS A0A252CV07_9NOSO/60-234     AC A0A252CV07.1
#=GS A0A101IIC6_9EURY/39-218     AC A0A101IIC6.1
#=GS J0N1H4_9CLOT/23-240         AC J0N1H4.1
#=GS Q81UJ4_BACAN/175-353        AC Q81UJ4.1
#=GS A0A1M5G4W1_9FLAO/108-282    AC A0A1M5G4W1.1
#=GS A0A1K1ME65_RUMFL/99-256     AC A0A1K1ME65.1
#=GS A0A286BW30_9ENTR/95-256     AC A0A286BW30.1
#=GS A0A231R3I8_9BACL/59-233     AC A0A231R3I8.1
#=GS A0A2C6UQH1_NOSLI/1-131      AC A0A2C6UQH1.1
#=GS G3HBA4_CRIGR/77-266         AC G3HBA4.1
#=GS M1V8V1_CYAM1/81-293         AC M1V8V1.1
#=GS A0A256YEG0_9CREN/41-211     AC A0A256YEG0.1
#=GS A0A1W9R810_9BACT/25-189     AC A0A1W9R810.1
#=GS A0A1V5ER06_9BRAD/183-352    AC A0A1V5ER06.1
#=GS A0A0T9P5C9_9GAMM/376-582    AC A0A0T9P5C9.1
#=GS A0A0M1J4H1_9GAMM/24-199     AC A0A0M1J4H1.1
#=GS R6A145_9BACT/26-206         AC R6A145.1
#=GS A9SHU6_PHYPA/137-301        AC A9SHU6.1
#=GS A0A0L0M7Z1_9BURK/27-173     AC A0A0L0M7Z1.1
#=GS A0A151F5J2_9EURY/77-278     AC A0A151F5J2.1
#=GS A3U779_CROAH/58-202         AC A3U779.1
#=GS D7GX28_9FIRM/107-275        AC D7GX28.1
#=GS A0A1T4JSH1_9BACT/51-216     AC A0A1T4JSH1.1
#=GS K2P2E6_9RHIZ/52-216         AC K2P2E6.1
#=GS A0A1F8AIK9_9EURO/445-629    AC A0A1F8AIK9.1
#=GS A0A1T5NGV8_9BACT/27-213     AC A0A1T5NGV8.1
#=GS A0A0Q6A6I7_9BRAD/33-190     AC A0A0Q6A6I7.1
#=GS A0A1M4N8H0_9CLOT/90-257     AC A0A1M4N8H0.1
#=GS A0A1J7C5M3_9GAMM/47-206     AC A0A1J7C5M3.1
#=GS A7HF82_ANADF/173-342        AC A7HF82.1
#=GS A0A2H9I038_9ARCH/143-316    AC A0A2H9I038.1
#=GS A5I7V3_CLOBH/24-223         AC A5I7V3.1
#=GS D4M9W3_9BACT/32-136         AC D4M9W3.1
#=GS A0A109N062_9BACI/106-282    AC A0A109N062.1
#=GS V4RNV8_9ROSI/121-285        AC V4RNV8.1
#=GS K9T3W7_9CYAN/11-151         AC K9T3W7.1
#=GS R5WEB3_9FIRM/199-373        AC R5WEB3.1
#=GS A0A163UKZ0_9BACT/51-211     AC A0A163UKZ0.1
#=GS V4Q8G8_9CAUL/125-301        AC V4Q8G8.1
#=GS A0A085BP68_9FLAO/61-241     AC A0A085BP68.1
#=GS A0A1E7KAK5_9ACTN/533-707    AC A0A1E7KAK5.1
#=GS A0A1H0K773_9PSEU/33-210     AC A0A1H0K773.1
#=GS A0A1M5YKF4_9FIRM/106-279    AC A0A1M5YKF4.1
#=GS D8JUP2_HYPDA/84-264         AC D8JUP2.1
#=GS A0A1D2RFD6_9EURY/179-343    AC A0A1D2RFD6.1
#=GS A0A023BMY0_9FLAO/5-176      AC A0A023BMY0.1
#=GS A0A0D0RR91_STAGA/27-178     AC A0A0D0RR91.1
#=GS A0A151EZ95_9EURY/8-167      AC A0A151EZ95.1
#=GS A0A0S6WXC4_9SPHN/197-336    AC A0A0S6WXC4.1
#=GS A0A1G1F5U3_9BACT/31-214     AC A0A1G1F5U3.1
#=GS D9SUF7_CLOC7/27-210         AC D9SUF7.1
#=GS A0A166CR53_DAUCA/112-281    AC A0A166CR53.1
#=GS Q0JZ70_CUPNH/201-363        AC Q0JZ70.1
#=GS A0A0Q4LPF5_9SPHI/146-319    AC A0A0Q4LPF5.1
#=GS A0A134ABT9_9FIRM/13-184     AC A0A134ABT9.1
#=GS A0A0D6TM47_9FLAO/38-165     AC A0A0D6TM47.1
#=GS A0A0L0AE70_9ENTR/79-235     AC A0A0L0AE70.1
#=GS RLMN_THEEB/102-271          AC Q8DG98.1
#=GS A4XKA1_CALS8/8-179          AC A4XKA1.1
#=GS A0A1M6T3A9_9FLAO/3-171      AC A0A1M6T3A9.1
#=GS A0A0M0BMQ0_9ARCH/229-415    AC A0A0M0BMQ0.1
#=GS A0A101GBA0_9BACT/24-189     AC A0A101GBA0.1
#=GS B4VE29_9ACTN/15-178         AC B4VE29.1
#=GS J2EVK2_9PSED/25-193         AC J2EVK2.1
#=GS A0A1H7S1Q9_9RHOB/75-240     AC A0A1H7S1Q9.1
#=GS A0A136J529_9PEZI/453-638    AC A0A136J529.1
#=GS A0A0D0Q087_KITGR/158-330    AC A0A0D0Q087.1
#=GS A0A0A7JR78_9PSED/23-195     AC A0A0A7JR78.1
#=GS A0A1B3NKD0_9BRAD/27-190     AC A0A1B3NKD0.1
#=GS A0A1T4L023_9FUSO/9-178      AC A0A1T4L023.1
#=GS A0A285NVE6_9EURY/58-247     AC A0A285NVE6.1
#=GS B2V7I2_SULSY/28-204         AC B2V7I2.1
#=GS A0A147KG97_9ACTN/120-297    AC A0A147KG97.1
#=GS A0A1C5DLG9_9ACTN/301-467    AC A0A1C5DLG9.1
#=GS E0STR7_IGNAA/23-189         AC E0STR7.1
#=GS R6D6F5_9BACE/140-312        AC R6D6F5.1
#=GS A0A238UGQ6_9FLAO/57-204     AC A0A238UGQ6.1
#=GS D4IM63_9BACT/63-236         AC D4IM63.1
#=GS A0A133UAX7_9EURY/232-400    AC A0A133UAX7.1
#=GS A0A1J1K0L2_9CYAN/53-237     AC A0A1J1K0L2.1
#=GS A0A174BD34_9CLOT/149-323    AC A0A174BD34.1
#=GS R5UMQ8_9FIRM/184-358        AC R5UMQ8.1
#=GS Q0YRQ9_9CHLB/201-367        AC Q0YRQ9.1
#=GS A0A0K9GET3_9BACI/180-345    AC A0A0K9GET3.1
#=GS B8GJL2_METPE/23-124         AC B8GJL2.1
#=GS R5LL52_9MOLU/144-314        AC R5LL52.1
#=GS A0A1F5AV12_9BACT/23-240     AC A0A1F5AV12.1
#=GS A0A125RCS0_9EURY/66-240     AC A0A125RCS0.1
#=GS A0A1B1AY91_9ACTN/270-433    AC A0A1B1AY91.1
#=GS A0A1G8U5I6_9ACTN/32-187     AC A0A1G8U5I6.1
#=GS A0A226YUS4_9BACI/150-322    AC A0A226YUS4.1
#=GS A0A014NYY5_9BURK/177-360    AC A0A014NYY5.1
#=GS A0A1L8SY42_9ENTE/30-195     AC A0A1L8SY42.1
#=GS A0A2G2DDK5_9DELT/17-166     AC A0A2G2DDK5.1
#=GS M7T9C3_9EURY/81-282         AC M7T9C3.1
#=GS A0A1I5C110_PARPN/95-252     AC A0A1I5C110.1
#=GS A0A098TI44_9CYAN/32-202     AC A0A098TI44.1
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