#=GF ID   RelB_N
#=GF AC   PF18506.2
#=GF DE   RelB Antitoxin alpha helical domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF01182
#=GF GA   31.00 31.00;
#=GF TC   31.30 32.20;
#=GF NC   30.50 30.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   19712680
#=GF RT   Crystal structure of the antitoxin-toxin protein complex
#=GF RT   RelB-RelE from Methanococcus jannaschii.
#=GF RA   Francuski D, Saenger W;
#=GF RL   J Mol Biol. 2009;393:898-908.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is an alpha helix domain found in the N-terminal region of
#=GF CC   antitoxin RelB. RelE-RelB (RelBE) is a toxin-antitoxin (TA)
#=GF CC   protein complex. It is suggested that the toxic action of RelE
#=GF CC   is counteracted by antitoxin RelB, which wraps around RelE,
#=GF CC   blocks its active site and prevents sterically the binding to
#=GF CC   the ribosomal A-site.The long N-terminal alpha-helix of the
#=GF CC   tightly bound antitoxin RelB covers the presumed active site of
#=GF CC   the toxin RelE that is formed by a central beta-sheet [1].
#=GF SQ   71
#=GS A0A0M9E8A4_9DELT/23-68  AC A0A0M9E8A4.1
#=GS A0A1E3XAZ7_9BACT/21-66  AC A0A1E3XAZ7.1
#=GS K9TZN0_CHRTP/17-63      AC K9TZN0.1
#=GS B0JW48_MICAN/17-63      AC B0JW48.1
#=GS A0A0C1XZ14_9CYAN/17-63  AC A0A0C1XZ14.1
#=GS W6LSJ5_9GAMM/16-62      AC W6LSJ5.1
#=GS A0A286U3H2_9BACT/16-63  AC A0A286U3H2.1
#=GS B7KK06_CYAP7/21-67      AC B7KK06.1
#=GS K9RTY1_SYNP3/17-63      AC K9RTY1.1
#=GS RELB2_METJA/16-61       AC P0CW76.1
#=GS K9W1V9_9CYAN/17-63      AC K9W1V9.1
#=GS A0A2T1G564_9CYAN/21-67  AC A0A2T1G564.1
#=GS A0A2K8SXV6_9NOSO/21-67  AC A0A2K8SXV6.1
#=GS RELB3_METJA/8-53        AC P0CL56.1
#=GS RELB3_METJA/8-53        DR PDB; 3BPQ C; 9-47;
#=GS RELB3_METJA/8-53        DR PDB; 3BPQ A; 8-48;
#=GS A0A0F3GKL9_9BACT/17-63  AC A0A0F3GKL9.1
#=GS K9YWI3_DACSA/17-54      AC K9YWI3.1
#=GS A0A2T1CFV8_9CYAN/20-66  AC A0A2T1CFV8.1
#=GS L8N3W3_9CYAN/1-30       AC L8N3W3.1
#=GS E0UD77_CYAP2/21-67      AC E0UD77.1
#=GS A0A1E3X8A7_9BACT/16-63  AC A0A1E3X8A7.1
#=GS B1WXG6_CROS5/21-67      AC B1WXG6.1
#=GS A0A1W2HAA9_9BACT/17-63  AC A0A1W2HAA9.1
#=GS K9V3E4_9CYAN/17-63      AC K9V3E4.1
#=GS A0A1Z4UIH7_9CYAN/21-67  AC A0A1Z4UIH7.1
#=GS A0A1Z4K2G1_9CYAN/17-63  AC A0A1Z4K2G1.1
#=GS A0A401IG25_APHSA/17-63  AC A0A401IG25.1
#=GS A0A2G4EWS9_9CYAN/21-67  AC A0A2G4EWS9.1
#=GS A0A1Z4JPM9_LEPBY/21-67  AC A0A1Z4JPM9.1
#=GS A0A139X0D1_9CYAN/17-63  AC A0A139X0D1.1
#=GS B4SCP7_PELPB/16-62      AC B4SCP7.1
#=GS S0G3K6_9DELT/17-63      AC S0G3K6.1
#=GS L8N1K0_9CYAN/17-63      AC L8N1K0.1
#=GS A0A2T1E4S8_9CYAN/17-63  AC A0A2T1E4S8.1
#=GS A0A2T1DLS2_9CYAN/17-67  AC A0A2T1DLS2.1
#=GS K7W9K4_9NOST/29-72      AC K7W9K4.1
#=GS B0JHM2_MICAN/21-67      AC B0JHM2.1
#=GS A0A172U736_9GAMM/29-74  AC A0A172U736.1
#=GS A0A1Q4RBF7_9CYAN/17-62  AC A0A1Q4RBF7.1
#=GS A0A433NP47_CHLFR/17-63  AC A0A433NP47.1
#=GS A0A1I5YWZ2_9BACT/17-63  AC A0A1I5YWZ2.1
#=GS A0A1E3XBG3_9BACT/16-64  AC A0A1E3XBG3.1
#=GS K7WRE6_9NOST/15-72      AC K7WRE6.1
#=GS S0FSH9_9DELT/18-64      AC S0FSH9.1
#=GS A0A0F2J2Z3_9BACT/36-82  AC A0A0F2J2Z3.1
#=GS J1L3G5_9EURY/17-63      AC J1L3G5.1
#=GS A0A2H5W3L2_9BACT/16-62  AC A0A2H5W3L2.1
#=GS A0A2T1C4X8_9CYAN/21-67  AC A0A2T1C4X8.1
#=GS A0A2S6CV03_9CYAN/17-61  AC A0A2S6CV03.1
#=GS L8LNF4_9CHRO/21-67      AC L8LNF4.1
#=GS K9TF77_9CYAN/17-63      AC K9TF77.1
#=GS D8FES4_9DELT/17-63      AC D8FES4.1
#=GS A0A126T7U0_9GAMM/16-60  AC A0A126T7U0.1
#=GS A0A1U7I959_9CYAN/21-67  AC A0A1U7I959.1
#=GS E1RI81_METP4/17-63      AC E1RI81.1
#=GS A0A0M1JRT1_9CYAN/21-67  AC A0A0M1JRT1.1
#=GS A0A1Z4LF42_NOSLI/17-63  AC A0A1Z4LF42.1
#=GS A0A401IGP5_APHSA/21-67  AC A0A401IGP5.1
#=GS A0A1U7ITZ0_9CYAN/17-62  AC A0A1U7ITZ0.1
#=GS A0A1C0VB87_9CYAN/17-63  AC A0A1C0VB87.1
#=GS A0A2T1DCR9_9CYAN/23-69  AC A0A2T1DCR9.1
#=GS A0A1Z4S9F3_9NOSO/17-63  AC A0A1Z4S9F3.1
#=GS D7CUH6_TRURR/19-65      AC D7CUH6.1
#=GS D6SU04_9DELT/17-63      AC D6SU04.1
#=GS K9W6L2_9CYAN/21-67      AC K9W6L2.1
#=GS L8M423_9CYAN/17-63      AC L8M423.1
#=GS A0A2D0HAM6_9NOSO/17-63  AC A0A2D0HAM6.1
#=GS K9Q7M0_9NOSO/21-67      AC K9Q7M0.1
#=GS Q1PVU5_KUEST/21-67      AC Q1PVU5.1
#=GS D8FZ04_9CYAN/17-63      AC D8FZ04.1
#=GS B8GGJ2_METPE/17-53      AC B8GGJ2.1
#=GS F4XYN4_9CYAN/144-190    AC F4XYN4.1
A0A0M9E8A4_9DELT/23-68             f--IVLPIKAYQQLI...........DFIEDYGLGLAM....K.E..AENSKRYSRETALRFLDD-e......
A0A1E3XAZ7_9BACT/21-66             t-KIIMDFNDYQRFL...........DWIEDEGLARAM....N.E..VKNEVPLNLEDALKELEK-.......
K9TZN0_CHRTP/17-63                 .IAVQIPIAEFEKIE...........EILEDYGLAQLM....N.E..VKDEKPLSKDEALQQLIK-e......
B0JW48_MICAN/17-63                 .IAVQIPIAEFEKIE...........EILEDYGLGKLI....E.E..VENDQILDKEKALQYLEL-l......
A0A0C1XZ14_9CYAN/17-63             .IAVQISIAEFEKIE...........AILEDYGLVKLM....E.E..VQNEKPLSKDEAIKYYQSL.......
W6LSJ5_9GAMM/16-62                 .VAVQLDMEIFEKIE...........EILENYGLVQFM....L.S..DGYEETLDIHQARNYYKSL.......
A0A286U3H2_9BACT/16-63             .IAVQLDIKTFEKIE...........EIFENYALYHLM....EkE..DNDDETLDLESAKEYYTT-l......
B7KK06_CYAP7/21-67                 .LKVVINFQDYERII...........EAIEDEGLYRAM....M.K..VKDETPLSIEEALAELEQQ.......
K9RTY1_SYNP3/17-63                 .LAVQIPIAVYHQIE...........AVLEDFGLAELM....K.E..VENDELLSGAAAESYYQSL.......
RELB2_METJA/16-61                  k-GVILDYKTFKKIE...........ELLLDYGLLKAM....E.E..VENEEEIDLETAKKLLEQ-.......
K9W1V9_9CYAN/17-63                 .IAVQISISEFTQIE...........EILENYGLVKLM....E.S..AEDNERLSKTQALQYYRSL.......
A0A2T1G564_9CYAN/21-67             s-QVILDYTDYQYFL...........EAIEDRGLLLAM....G.G..VKNETPLNLQQALAELETE.......
A0A2K8SXV6_9NOSO/21-67             .LKVVLEFEVYQRLL...........DAIEDEGLYRAM....Q.A..VKGETPLSRNEALEELEQL.......
RELB3_METJA/8-53                   k-KFFISRKEYEKIE...........EIL-DIGLAKAM....E.E..TKDDELLTYDEIKELLGD-k......
#=GR RELB3_METJA/8-53        SS    ---EEE-CHHHHHHH...........HHH-HHHHHHHH....H.T..TTT--EEECCCHH-XXXX-X......
A0A0F3GKL9_9BACT/17-63             .LAVEIDIDTFNKIE...........EILEDYGLYRLM....T.D..DNDNEMLDIDEAKRFYST-l......
K9YWI3_DACSA/17-54                 .IAVQIPIAEFEKIE...........EILEDYGLVQLM....E.A..VSDDETLN-----------mv.....
A0A2T1CFV8_9CYAN/20-66             r-QVILNFEDYQQLL...........EGLEDEALYQAM....K.T..TINETPMSREEVLKALEE-e......
L8N3W3_9CYAN/1-30                  .--------------...........--MENFGLAKLM....Q.E..VEDDKLLSGDAAYSYYQ--i......
E0UD77_CYAP2/21-67                 .LKVVINFQDYERII...........EAIEDEGLYRAM....K.E..VKDETPLSLEQALAELEQE.......
A0A1E3X8A7_9BACT/16-63             .IAVQLDIKTFKKIE...........EIFKNHALYHLM....Q.E.eDTDDEVLDLEQAKEYYDTL.......
B1WXG6_CROS5/21-67                 .CQVIMDFTDYQKLL...........ETLEDEGLYRAI....M.E..VRQEKPLTVSEALEELEK-s......
A0A1W2HAA9_9BACT/17-63             .VAVQIDINDYEKLE...........QLIEDYALGKYM....E.E..NDPTEVLTLNEAKVLYEK-m......
K9V3E4_9CYAN/17-63                 .IAVQIPIAEFEKIE...........EILENYGLVQLI....E.E..SEDDERFAKDEAWKYYQ--yl.....
A0A1Z4UIH7_9CYAN/21-67             r-KVVMDFQEYLRLL...........EALEDEGLILAM....K.E..VENETPLNLDEALAELEQE.......
A0A1Z4K2G1_9CYAN/17-63             .IAVQIPIADFEKIE...........EILENYGLVKLM....A.E..SEDDERLSKDEAVKYYQ--yl.....
A0A401IG25_APHSA/17-63             .IAVQIPIAEFEKIE...........EILEDYGLGKLI....E.E..VENDETLSKQEALKYLK--li.....
A0A2G4EWS9_9CYAN/21-67             s-QVILDYTDYQYFL...........EAMEDRGLLLAM....G.T..VKNETPLNLHQALAELETE.......
A0A1Z4JPM9_LEPBY/21-67             r-KVVIDITDYRKLI...........EAIEDEGLYRAM....L.E..ARREEPLSLEEARKEMEKE.......
A0A139X0D1_9CYAN/17-63             .IAVQIPIADFEKIE...........EILENYGLAKLM....E.E..SEDNERLSKDKALRYYQSL.......
B4SCP7_PELPB/16-62                 q-SVILDYQIYQKIE...........ELLLDDGLLKAM....E.E..VQDEETVEYEEVRELIKQL.......
S0G3K6_9DELT/17-63                 .IAVQIPIEDFEKIE...........QLLEDYALFHLM....K.D..NQGTELLDQTDAETYYKQL.......
L8N1K0_9CYAN/17-63                 .LAVQIPIAIYNQIE...........EILENFGLAKLM....Q.E..VDDDELLSGDEAYSYYQSL.......
A0A2T1E4S8_9CYAN/17-63             .IAVQIAIADFEHIE...........EILEDFGLVKLM....E.A..TEDSERLSKVDALAYYRSL.......
A0A2T1DLS2_9CYAN/17-67             .VAVQIPIAEFERIE...........EILEDYGLAQLIatpfE.N..SEDGDRLNREDALNYYRSL.......
K7W9K4_9NOST/29-72                 .IAVQIPMTEFEQIE...........EILENYGLAQLM....Q.E..VETDEILSK----------rvfekfl
B0JHM2_MICAN/21-67                 .QQVIINFEDYQQII...........ETYEDTGLYRAM....I.D..VKDETPLTLEEALIELEKE.......
A0A172U736_9GAMM/29-74             .VAVQLDIHTFEKIE...........NVLENYALVQLI....-.N..TDDTETLSIEEAKKYYAG-l......
A0A1Q4RBF7_9CYAN/17-62             .IAVQIPIAEFEKIE...........EILENYGLVKLM....-.E..ADDDERLSKEEALKYYQSL.......
A0A433NP47_CHLFR/17-63             .IAVQIPIADFEKIE...........EILENYGLVQLM....E.E..SKDEERLSKDEAWKYYQ--yl.....
A0A1I5YWZ2_9BACT/17-63             .IAVQLDIKVFKRLE...........EVLEDYALAQYM....K.E..TDTEEKLTLNEAKAYYKKL.......
A0A1E3XBG3_9BACT/16-64             .IAVQLDIKTFEKIE...........EIFENYALSHLM....Q.EedNDDGEILDLEQAKEYYDTL.......
K7WRE6_9NOST/15-72                 .IAVVIPIDIWRKLLptedtsldeltEAIEDYCLNKAM....D.E..SMNTPLLDRNQALAYLEE-e......
S0FSH9_9DELT/18-64                 .IAVQIPIKDFEKIE...........QLLEDYALFHLM....K.D..NQGEELMNQKDAETYYKQL.......
A0A0F2J2Z3_9BACT/36-82             .LAVEIYIETFKKIE...........DILEDYGLYHLM....T.D..DMKAESLSLEQAKEYYRL-e......
J1L3G5_9EURY/17-63                 v-GVIIDIATFERIE...........SILEDYGLAQFI....N.E..ADDEEPLDRAGAQKKI---rgp....
A0A2H5W3L2_9BACT/16-62             .VAVQIDIETFAKIE...........RILEDYALGQLI....A.E..VAEDEALDYESARAYYEQL.......
A0A2T1C4X8_9CYAN/21-67             .QQVVLDFNDYQHLL...........EAIEDESLILAM....K.E..VQNETPLSISEALAELEKE.......
A0A2S6CV03_9CYAN/17-61             .IAVQIPITEFEQIE...........EILENYGLAKLM....E.E..VEDDEILSKNES-------yqift..
L8LNF4_9CHRO/21-67                 .LQIVINFQDYEWII...........ETVEDEGLYRAM....M.E..VKDETPLSFEDALAELEKE.......
K9TF77_9CYAN/17-63                 .IAVQIPIAEFEKIE...........EILENYGLAKLM....E.E..VKDEKSLSKEEALKYYESL.......
D8FES4_9DELT/17-63                 .VAVQIPIDVFERLE...........EILENYGLVQLM....K.E..NDGGETLGVNEAKAYYDRL.......
A0A126T7U0_9GAMM/16-60             .VAVQLDIDTFEKIE...........NVLENYALVQLI....-.N..ADSSEILNFEEAKKYYA--r......
A0A1U7I959_9CYAN/21-67             .QKVVIDFSDYQHLL...........EAIEDEGLIRAM....N.E..VKGETGFTLDEALAELEKE.......
E1RI81_METP4/17-63                 v-GVILDISTFEKIE...........SVIEDFGLAKCI....N.E..ADDEEPLNRSDALKYYRGL.......
A0A0M1JRT1_9CYAN/21-67             r-KVILDFNDYKRLL...........EVIEDEGLYRAM....M.E..VKNETSLDLESALAELEKE.......
A0A1Z4LF42_NOSLI/17-63             .IAVQIPIAEFEKIE...........EILEDYGLAKLM....E.E..VQEEKPLSKDEALKYYQSL.......
A0A401IGP5_APHSA/21-67             .LKVVINFQDYKHII...........EAIEDEGLYRAM....M.E..VKNETPLSLEEALTELEQE.......
A0A1U7ITZ0_9CYAN/17-62             .IAVQIPIAEFEKIE...........EILEDYGLAKLI....K.E..SENEKRLSKEVALNYYR--y......
A0A1C0VB87_9CYAN/17-63             .IAVQIPLEQFEKIE...........EILENYGLAKLI....Q.E..TEDDERLSKEQALNYYNS-i......
A0A2T1DCR9_9CYAN/23-69             r-KVVIDVADYQKLI...........EALEDEGLYRAV....A.E..VRNEIPLSLEEALKEMA--ae.....
A0A1Z4S9F3_9NOSO/17-63             .IAVQIPIAEFEKIE...........EILENYGLAKLM....E.E..VEDEELLSKDEALKYYQSL.......
D7CUH6_TRURR/19-65                 t-HVLLPIEQYEKLL...........EALEDEGLVRAL....R.E..TAGDDLLGPEQARLALEDE.......
D6SU04_9DELT/17-63                 .VAIQIPIQEFEYLE...........EIIENHGLARLM....E.E..AADEEKLSVNEAKDYYQSL.......
K9W6L2_9CYAN/21-67                 k-KVIIDFPDYLRLL...........EAIEDEGLILAM....Q.E..VQHETPLNLNEVLLELEKQ.......
L8M423_9CYAN/17-63                 .IAVQIPIAEFEKIE...........EILEDYGLAQLM....D.E..TKDDKTLNKQEALNYLASL.......
A0A2D0HAM6_9NOSO/17-63             .IAVQIPIAEFEKIE...........EILEDYGLAKLM....E.E..VEEEKPLSKDEALQYYQSL.......
K9Q7M0_9NOSO/21-67                 .LKVVLEFQEYQRLL...........DAIEDEGLYRAM....Q.A..VSGETPLSINEALEELEK-p......
Q1PVU5_KUEST/21-67                 t-KIIMDFDDYQRFL...........DWVEDEGLVLAM....N.E..VENEASMSLEKALNELEK-k......
D8FZ04_9CYAN/17-63                 .IAVQIPLEQFEKIE...........EILENYGLAKLI....E.E..TEDDERLSKEQALNYYNS-i......
B8GGJ2_METPE/17-53                 .QAVIVDLETFNRME...........SIIEDNGLAKFM....E.E..AEEDESL------------yg.....
F4XYN4_9CYAN/144-190               e-KVLIYFQDYERLI...........ESFEDEGLYRAM....M.E..VKDETPLSLEEALAELDKE.......
#=GC SS_cons                       ---EEE-CHHHHHHH...........HHH-HHHHHHHH....H.T..TTT--EEECCCHH-XXXX-X......
#=GC seq_cons                      .luV.Islp-ac+IE...........ElLEDaGLs+hM....p.E..scs-c.Loh--Ahphhcp........
//