#=GF ID RnlA_toxin
#=GF AC PF15935.9
#=GF DE RNase LS, bacterial toxin
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE Pfam-B_18707 (release 26.0)
#=GF GA 27.00 27.00;
#=GF TC 27.20 27.10;
#=GF NC 26.90 26.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 21927020
#=GF RT Regulation of growth and death in Escherichia coli by
#=GF RT toxin-antitoxin systems.
#=GF RA Yamaguchi Y, Inouye M;
#=GF RL Nat Rev Microbiol. 2011;9:779-790.
#=GF RN [2]
#=GF RM 20980243
#=GF RT Escherichia coli rnlA and rnlB compose a novel toxin-antitoxin
#=GF RT system.
#=GF RA Koga M, Otsuka Y, Lemire S, Yonesaki T;
#=GF RL Genetics. 2011;187:123-130.
#=GF DR INTERPRO; IPR031845;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC RnlA_toxin is an RNase LS and a putative toxin of a bacterial
#=GF CC toxin-antitoxin pair. Toxin-antitoxin systems consist of a
#=GF CC stable toxin and an unstable antitoxin. In this case, a novel
#=GF CC type II system, RnlA is the stable toxin that causes inhibition
#=GF CC of cell growth and rapidly degrades T4 late mRNAs to prevent
#=GF CC their expression, and this is neutralised by the activity of the
#=GF CC unstable antitoxin RnlB [1, 2].
#=GF SQ 40
#=GS R5HGM4_9MOLU/92-172 AC R5HGM4.1
#=GS A0A2R5FX74_NOSCO/94-185 AC A0A2R5FX74.1
#=GS A0A845GNN9_9BURK/92-174 AC A0A845GNN9.1
#=GS A0A7U9TIP4_9MOLU/226-308 AC A0A7U9TIP4.1
#=GS A0A7W2ENA5_9BURK/94-179 AC A0A7W2ENA5.1
#=GS A0A1Q2SMK9_9GAMM/94-179 AC A0A1Q2SMK9.1
#=GS A0A1B6BF20_9FIRM/101-188 AC A0A1B6BF20.1
#=GS LSOA_ECO57/90-174 AC O82881.1
#=GS I9LJM3_9FIRM/96-182 AC I9LJM3.1
#=GS A0A1R3T3Z7_9BACT/117-200 AC A0A1R3T3Z7.1
#=GS A0A0F5IPM6_9BACT/92-175 AC A0A0F5IPM6.1
#=GS J4TIL4_9FIRM/226-315 AC J4TIL4.1
#=GS Q6AIF4_DESPS/91-176 AC Q6AIF4.1
#=GS A8H216_SHEPA/99-184 AC A8H216.1
#=GS A0A235F597_9BACI/103-188 AC A0A235F597.1
#=GS A0A5B8YI56_9FLAO/91-174 AC A0A5B8YI56.1
#=GS A0A6B3W4C2_9BACI/314-390 AC A0A6B3W4C2.1
#=GS R1ASA3_9FIRM/101-185 AC R1ASA3.1
#=GS F7Q2N3_9MOLU/227-317 AC F7Q2N3.1
#=GS E6SSM9_BACT6/92-175 AC E6SSM9.1
#=GS A0A420XHI8_9PAST/93-178 AC A0A420XHI8.1
#=GS A0A1G8CD09_9VIBR/97-182 AC A0A1G8CD09.1
#=GS B3PN28_META1/220-308 AC B3PN28.1
#=GS A0A1Y4EVM1_9FIRM/230-321 AC A0A1Y4EVM1.1
#=GS A0A1S2LYS0_9BACI/317-390 AC A0A1S2LYS0.1
#=GS A0A1I0M210_9FIRM/99-183 AC A0A1I0M210.1
#=GS A0A842IX81_9FUSO/99-181 AC A0A842IX81.1
#=GS RNLA_ECOLI/98-183 AC P52129.2
#=GS I5B0B2_9DELT/91-177 AC I5B0B2.1
#=GS A0A1G6W110_PEPNI/227-316 AC A0A1G6W110.1
#=GS A0A8H2QT99_9FIRM/225-312 AC A0A8H2QT99.1
#=GS A0A133YXK3_9FIRM/241-330 AC A0A133YXK3.1
#=GS Q5LEL8_BACFN/92-175 AC Q5LEL8.1
#=GS R7MKU9_9FIRM/179-264 AC R7MKU9.1
#=GS A0A3R6ILL0_9BACT/92-175 AC A0A3R6ILL0.1
#=GS A0A081P3B2_9BACL/96-182 AC A0A081P3B2.1
#=GS Q6LR54_PHOPR/93-183 AC Q6LR54.1
#=GS A0A1D9P153_9FIRM/93-175 AC A0A1D9P153.1
#=GS A0A1M7S085_9DELT/6-76 AC A0A1M7S085.1
#=GS A0A2K9EV90_9RHOB/94-177 AC A0A2K9EV90.1
R5HGM4_9MOLU/92-172 ................qpkqtvfs---------CNKETIEELIKCVE.D.....EFSSEIQ..IK--YYS..NN---RI..RFI.GYNKDHIDITFY.pQTNKVMIQGRPFKTFGIIMTLLSQL--s.........
A0A2R5FX74_NOSCO/94-185 .....................kai---SVSVKNINQDTFNLLIEFLE.ElknedSDVTEIS..-VARISE..ALTKKSI..KVT.SKYNDSLTLTHY.qSTNTLLIQGKPLYGYYQVSYFLAQF--td........
A0A845GNN9_9BURK/92-174 ......................eq--RPLVLQQITEKDWQFMLDHLS.D.....DWKFQVT..-----QE..QLEHGVR.fRVK.KAHGDEVVIHRY..NTGRFLMQGKAREVYGIVSSVLCEL--ap........
A0A7U9TIP4_9MOLU/226-308 ......................gk--NFVVFNNFSDKQFDELFSNIS.T.....DMHEISV..--EDRSD..KDKKCY-..-VL.SYDRERLFVTYYntKRKTLMIQGNQERLFFVLLDNII----ln........
A0A7W2ENA5_9BURK/94-179 ........................ENVNYSLKGITSDSFDPILDCLN.E.....SSDIEIT..--TLRDE..SICKQVT..LRS.VAHQDSLTLTHH.rTTRVLQIQGKPLSCYRRVIFMLTDLLD..........
A0A1Q2SMK9_9GAMM/94-179 .......................k-NLNYSLKGITVDSFDSILDLLK.E.....SGDIEIN..--TLRNE..AVCKRVS..LKS.IAYQDSLTLTHH.rSTRVLQIQGKPLSCYRRVIFMLIDLLD..........
A0A1B6BF20_9FIRM/101-188 .......................k-NSWFVVHPIEKDTIECIIDILE.A.....NIDDNYL..LNKEIST..GLQGRIW..KLK.GKFGEKVVIHYY.nATNKVMVQGKPRLLFTMITTGISELLD..........
LSOA_ECO57/90-174 ........................KNFEYTIPKFSDDDRANLFEFLS.E.....EGITITE..--DNNND..PNCKHQY..IMT.TSNGDRVRAKIY..KRGSIQFQGKYLQIASLINDFMCSILN..........
I9LJM3_9FIRM/96-182 ........................NNRSMTFQNISVEEYNSIIELIK.E.....DTENCSS..ILSEQNS..EN-SNIT..KFE.GKWSDKVTIVYT.kSTKRARVQGRPLLLYNVITSYFNELVD..........
A0A1R3T3Z7_9BACT/117-200 .......................e-RKSVTLNNVGGDNFLAFIETLE.E.....AGYTIKN..--KDIKD..PNIKYSY..KII.GKYKDELNVNYY..NNRTLLAQGRITPLFL-----------dftvqytpll
A0A0F5IPM6_9BACT/92-175 ........................DKKSFTAKGISEEDFDAFIDVLS.E.....SDEIEIT..TVNTDNN..PAIRNQY..HLK.GKYDAKVSIIFY..NNGTLFLQGAVTAFY---IELITEIME..........
J4TIL4_9FIRM/226-315 .......................e-DGSVYFIGFGKQDWICIVNKLN.K....dIESKNIN..KKITISE..SKPKEYCdrLEF.TCKKEKVVINCY..RGDKSYVQGKPSTLLQNIISSAIE---nlk.......
Q6AIF4_DESPS/91-176 .......................k-SVNCTFKGLLEEEFGIFEEYVI.E.....ELPDISS..--KIQKD..DKTKKTI..SYS.GKYSDTVTVTFY.kTTGTTLLQGRPLPAFFEIKAL------fagive....
A8H216_SHEPA/99-184 .......................e-SVNMVVDGFIEESISPVLLCTA.D.....ETYIELQ..---EHHR..EASKIVW.kLIS.IEFQDELTVTLH.tTTRLLQIQGRPLSCYRAFIFNLTELLD..........
A0A235F597_9BACI/103-188 ....................dkpf----FVFKNVEYEDFTTVLNLVK.E.....LDGVSEN..--SNRVV..PGGNQWV..LKS.SVNNETVTISYF.lKTKKAMVQGKPLKLFTETYTYLLNLMD..........
A0A5B8YI56_9FLAO/91-174 ......................na--NSFYLKAIRIEDFNVVLDFLT.H.....DCNAEVL..-SDTKNT..NG--RHI..KLK.GAQGDKMVLNHF..NNGSFQAQGKPRMLFHDTIMILSELLP..........
A0A6B3W4C2_9BACI/314-390 ............htfrinkewsyn-----------------LVGFLG.E.....LEDIEKD..--CIQHE..NPKYEQC..KFV.SAKGDRLNINIY..ETGNVVLQGKPAYLYTEALSFL-----sy........
R1ASA3_9FIRM/101-185 ...................svsfs-------TNINKEKVEFLIEYLN.S.....IKGVELV..-KNETVN..NGYGTLY..QFN.SNIGDKITLTYY.eTTDKLLYQGKIMKLYIEVKNL------leglvn....
F7Q2N3_9MOLU/227-317 .......................n-DGSIYFVGYDVADWKNIIKEISlE.....NDELNNE..NEEI-ESyiEDIKEYLkqIRV.QYINDRLTINCY..KGSKSYVQGKQTVLFQKLISYAIE---klp.......
E6SSM9_BACT6/92-175 ........................DKKSFTAKGISEEDFDAFIDVLS.E.....SDEIEIT..TVNTDNN..PAIRNQY..HLK.GKYDAKVSIIFY..NNGTLFLQGAVTAFY---IELITEIME..........
A0A420XHI8_9PAST/93-178 ......................ks--LNILIKGISNTTMEKIFSEIE.S....iQGINKIN..I-T-PKK..INGGTLY.eLKS.ETFDDQLNLSYY.dKNHNLLIQGRPLSCYKVVAYSLS----md........
A0A1G8CD09_9VIBR/97-182 ........................EQVNLVLKGFIETMLIPVLEVTG.E.....EAHIEIN..--EHSRD..KLKT-VW.kILS.KEYQDEITVTLH.nSTRTLHIQGRPLSCYRAFIFNISELLD..........
B3PN28_META1/220-308 ........................DDGSILFTSFQKQDWLDIIQKLK.E.....KNELNIL..IEEGIVD..ENKKSYLnrLIF.RLDKDKVTINCY..SNNKSYVQGKQSMLFQIIITAAIEMLP..........
A0A1Y4EVM1_9FIRM/230-321 .......................n-DGSVYFVGYSVQDWKTIIQCIN.DenaefADEKTIS..PLTFSQE..TIGTREK..IRV.TQDRNTVVINCY..RNSKTYVQGKQTVLFQKIISTAIELL-g.........
A0A1S2LYS0_9BACI/317-390 ritqewsyklvdfleglediskdc-----------------------.-.....-------..---IHHE..NPKYEQC..KFL.STKGDRLNINIY..ETGKVVLQGKPAYLYTEAMSFLS----y.........
A0A1I0M210_9FIRM/99-183 ...............nngfsvisn-----------EETFNAIIDFLN.E.....FDEAEKIgyNKFNEIG..KAKYEQY..KYK.SNLGDSIVIKFF.eSNSRIQIQGKPLYLFNCVEDI------lvt.......
A0A842IX81_9FUSO/99-181 .......................k-ENHFTLKNIEKEIFETLICLLK.E.....EEE-NFE..IKEENLE..MN--RIK..IES.KIDKMQITMTYY..PTKTLLVQGKPAHCYWSIFKLLIK---le........
RNLA_ECOLI/98-183 ........................EQVNMVLQGFVETSVLPVLELSA.D.....ESHIEFR..----EHS..RNAHTVVwkIIS.TSYQDELTVSLH.iTTGKLQIQGRPLSCYRVFTFNLAALLD..........
I5B0B2_9DELT/91-177 ........................HNNCITYRKIKQDDFELLLEYLD.T.....EEAVKSE..SLEPYKT..NNNHTIF..KIS.SIYKDETTLTQY..ANQTILLQGRPLYIYNVIKSFINELID..........
A0A1G6W110_PEPNI/227-316 .......................n-DGSIYFIGFQKQDWLNMVESLN.Ne..inEEDIKDK..IKVEESS..P--KDYLdkLLL.VFDGQRVIINCY..KGNKSYVQGKQSLLFRKIISLAIE---nlp.......
A0A8H2QT99_9FIRM/225-312 .......................s-DGSIYFIGLDKDSWIQIIKEIQ.Ad..feEEKQKIV..----YKS..EQIKDYL.nKVKvQRGSEKLVINCY..TGQKSYVQGKQSSLFQKLVTYAIE---qlp.......
A0A133YXK3_9FIRM/241-330 .......................n-DGSIYFIGFQKQDWISMVESLN.Ne..inE--ENIE..YNIRVEE..SNPKDYLdkLLL.IFDGQRVIINCY..KGNKSYVQGKQSLLFQKIISLAIE---klp.......
Q5LEL8_BACFN/92-175 ........................DKKSFTAKGISEEDFDAFIDVLS.E.....SDEIEIT..TVNTDNN..PAIRNQY..HLK.GKYDAKVSIIFY..NNGTLFLQGAVTAFY---IELITEIME..........
R7MKU9_9FIRM/179-264 ........................ENASCTFENISDDVFDKLLSYFN.E.....DDRISVV..SDEEKDT..SPKHRAI..QCK.SKFGDKLFIRHY..ENKSVLIQGNPAYIFSQLMYFMS-IQD..........
A0A3R6ILL0_9BACT/92-175 ........................DKKSFTAKGISEEDFDAFIDVLS.E.....SDEIEIT..TVNTDNN..PAIRNQY..HLK.GKYDAKVSIIFY..NNGTLFLQGAVTAFY---IELITEIME..........
A0A081P3B2_9BACL/96-182 .......................k-SKCFVAPNIELDDFRGIVELLK.E.....STYYQSE..-SHSEDI..RGNHELH..KMR.GSYMEEITAHYY.yTTKKVMIQGRPLMLFSEAVSYITELLE..........
Q6LR54_PHOPR/93-183 ........................NKANLVLKGMSSDEIEFVLALMG.De..lvEGEKAFS..ITTANPT..PICQKYT..ITC.DKFKDNIVLLYH.tTTYKLQIQGRALFCYRTLCYHLSALLD..........
A0A1D9P153_9FIRM/93-175 ........................ENTTCSFKKLPYEWGDKLIKYLT.S.....CPGIKIS..-ATEIDK..APKHIEY..DLS.SNYGDKLVINRY..SNGTLVLQGKPAYIFGEAIS-------llsy......
A0A1M7S085_9DELT/6-76 ....................ikmp--------------FKKVLKSLD.D.....SNIKYTQ..---ERNK..DQTGTII..RLK.TKKISSVTITTY..DNGTLLIQSKNTTAYNFVKDC------lly.......
A0A2K9EV90_9RHOB/94-177 ........................ENVNYALKGITSESFDSILDLME.D.....GVEVATN..----RND..ELTKQVT..LKS.VEHHDSLKLTHH.rRTRVLQVQGKPLSCYRRVIFMLTDLLD..........
#=GC seq_cons .........................phshshpshsp-sapsllchLs.-.....psphphs....pppps..sst+phh..hhp.sphpDclslshY..sssplhlQG+shhhaptlhphl.ph............
//
