#=GF ID   Rubella_E1
#=GF AC   PF05748.15
#=GF DE   Rubella membrane glycoprotein E1
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_6726 (release 8.0)
#=GF GA   25.00 25.00;
#=GF TC   28.80 523.70;
#=GF NC   21.70 21.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0543
#=GF RN   [1]
#=GF RM   11682134
#=GF RT   Effect of site-directed asparagine to isoleucine substitutions
#=GF RT   at the N-linked E1 glycosylation sites on rubella virus
#=GF RT   viability. 
#=GF RA   Ramanujam M, Hofmann J, Nakhasi HL, Atreya CD; 
#=GF RL   Virus Res 2001;81:151-156.
#=GF DR   INTERPRO; IPR008820;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Rubella virus (RV), the sole member of the genus Rubivirus
#=GF CC   within the family Togaviridae, is a small enveloped, positive
#=GF CC   strand RNA virus.  The nucleocapsid consists of 40S genomic RNA
#=GF CC   and a single species of capsid protein which is enveloped within
#=GF CC   a host-derived lipid bilayer containing two viral glycoproteins,
#=GF CC   E1 (58 kDa) and E2 (42-46 kDa).  In virus infected cells, RV
#=GF CC   matures by budding either at the plasma membrane, or at the
#=GF CC   internal membranes depending on the cell type and enters
#=GF CC   adjacent uninfected cells by a membrane fusion process in the
#=GF CC   endosome, directed by E1-E2 heterodimers. The heterodimer
#=GF CC   formation is crucial for E1 transport out of the endoplasmic
#=GF CC   reticulum to the Golgi and plasma membrane. In RV E1, a cysteine
#=GF CC   at position 82 is crucial for the E1-E2 heterodimer formation
#=GF CC   and cell surface expression of the two proteins. The E1 has been
#=GF CC   shown to be a type 1 membrane protein, rich in cysteine residues
#=GF CC   with extensive intramolecular disulfide bonds [1].
#=GF SQ   4
#=GS A0A7L5KVN7_9VIRU/517-1016  AC A0A7L5KVN7.1
#=GS POLS_RUBVM/568-1063        AC P08563.2
#=GS POLS_RUBVT/568-1063        AC P07566.1
#=GS G3M8I1_RUBV/568-1063       AC G3M8I1.1
A0A7L5KVN7_9VIRU/517-1016             a-TAALMCGHALFTAGEEARGSIAAVAGARGTVGVPVEVLAVSWTSHPVDGGCFQPWDLEATGACICDVPTDVSCAGLQPAVRLETCERVMAGSPHSCTMWVLNPYSVGGYAQLGSYFADDDSgWYKQYHPTVCRVRAAFDHPSDACWGFAADTTMSVVGVAGYVYHPNKTVNVTHHRAVQRRYTVRVGGTTCNVSAVQPVCSLPSGEMYFELPADPGDLTEYRITLADRADTrRFVPGAPDCFGPAWASPVCARHMPDCSRTVGATPGPPTLRLFAADDLGWHEPVPPGEVWYQPVIGRQPRTCSLNIRAGPYGHAAVEMPEWLLDHTVPDPLLPTEPLRLTLRTTRSIRSGSPMGPPSGVRVEGCWACGTPAALSAELPSGGPCELRVNGRLIGTFPPGPLRTRALIDTAPPYRASCAGTAVDApvAAAVSGPATASFAGVVYGPVTSHVASTSQTWLEWARSHWWALLLATLAALLGSCLLASVARCLFYLRGAIAP-a
POLS_RUBVM/568-1063                   .LTAVVLQGYNPPAYGEEAFTYLCTAPGCATQTPVPVRLAGVRFESKIVDGGCFAPWDLEATGACICEIPTDVSCEGLGAWVPTAPCARIWNGTQRACTFWAVNAYSSGGYAQLASYFNPGGS.YYKQYHPTACEVEPAFGHSDAACWGFPTDTVMSVFALASYVQHPHKTVRVKFHTETRTVWQLSVAGVSCNVTTEHPFCNTPHGQLEVQVPPDPGDLVEYIMNYTGNQQS.RWGLGSPNCHGPDWASPVCQRHSPDCSRLVGATPERPRLRLVDADDPLLRTAPGPGEVWVTPVIGSQARKCGLHIRAGPYGHATVEMPEWIHAHTTSDPWHPPGPLGLKFKTVRPVALPRALAPPRNVRVTGCYQCGTPALVEGLAPGGGNCHLTVNGEDVGAFPPGKFVTAALLNTPPPYQVSCGGESDRA..SARVIDPAAQSFTGVVYGTHTTAVSETRQTWAEWAAAHWWQLTLGAICALLLAGLLACCAKCLYYLRGAIAPR.
POLS_RUBVT/568-1063                   .LTAVVLQGYNPPAYGEEAFTYLCTAPGCATQAPVPVRLAGVRFESKIVDGGCFAPWDLEATGACICEIPTDVSCEGLGAWVPAAPCARIWNGTQRACTFWAVNAYSSGGYAQLASYFNPGGS.YYKQYHPTACEVEPAFGHSDAACWGFPTDTVMSVFALASYVQHPHKTVRVKFHTETRTVWQLSVAGVSCNVTTEHPFCNTPHGQLEVQVPPDPGDLVEYIMNYTGNQQS.RWGLGSPNCHGPDWASPVCQRHSPDCSRLVGATPERPRLRLVDADDPLLRTAPGPGEVWVTPVIGSQARKCGLHIRAGPYGHATVEMPEWIHAHTTSDPWHPPGPLGLKFKTVRPVALPRTLAPPRNVRVTGCYQCGTPALVEGLAPGGGNCHLTVNGEDLGAVPPGKFVTAALLNTPPPYQVSCGGESDRA..TARVIDPAAQSFTGVVYGTHTTAVSETRQTWAEWAAAHWWQLTLGAICALPLAGLLACCAKCLYYLRGAIAPR.
G3M8I1_RUBV/568-1063                  .LTAVVLQGYTPPAYGEEAFTYLCTAPGCATQAPVPVRLAGVRFESKIVDGGCFAPWDLEATGACICEIPTDVSCEGLGAWVPAAPCARIWNGTQRACTFWAVNAYSSGGYAQLASYFNPGGS.YYKQYHPTACDVEPAFGHSDAACWGFPTDTVMSVFALASYVQHPDKTVRVKFHTETRTVWQLSVAGVSCNVTTEHPFCNTPHGQLEVQVPPDPGDLVEYIMNYTGNQQS.RWGLGSPNCHGPDWASPVCQRHSPDCSRLVGATPERPRLRLVDADDPLLRTAPGPGEVWVTPVIGSQARKCGLHIRAGPYGHATVEMPEWIHAHTTSDPWHPPGPLGLKFKTVRPVVLPRALAPPRNVRVTGCYQCGTPALVEGLAPGGGNCHLTVNGEDVGAFPPGKFVTAALLNTPPPYQVSCGGESDRA..SARVIDPAAQSFTGVVYGTHTTAVSETRQTWAEWAAAHWWQLTLGVICALLLAGLLACCAKCLYYLRGAIAPR.
#=GC seq_cons                         .LTAVVLQGYsPPAYGEEAFTYLCTAPGCATQsPVPVRLAGVRFESKIVDGGCFAPWDLEATGACICEIPTDVSCEGLGAWVPsAPCARIWNGTQRACTFWAVNAYSSGGYAQLASYFNPGGS.YYKQYHPTAC-VEPAFGHSDAACWGFPTDTVMSVFALASYVQHPcKTVRVKFHTETRTVWQLSVAGVSCNVTTEHPFCNTPHGQLEVQVPPDPGDLVEYIMNYTGNQQS.RWGLGSPNCHGPDWASPVCQRHSPDCSRLVGATPERPRLRLVDADDPLLRTAPGPGEVWVTPVIGSQARKCGLHIRAGPYGHATVEMPEWIHAHTTSDPWHPPGPLGLKFKTVRPVsLPRsLAPPRNVRVTGCYQCGTPALVEGLAPGGGNCHLTVNGEDlGAFPPGKFVTAALLNTPPPYQVSCGGESDRA..oARVIDPAAQSFTGVVYGTHTTAVSETRQTWAEWAAAHWWQLTLGsICALLLAGLLACCAKCLYYLRGAIAPR.
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