GenomeNet

Database: Pfam
Entry: RuvC_1
LinkDB: RuvC_1
Original site: RuvC_1 
#=GF ID   RuvC_1
#=GF AC   PF18516.2
#=GF DE   RuvC nuclease domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF06095
#=GF GA   26.20 26.20;
#=GF TC   33.30 108.10;
#=GF NC   26.10 24.00;
#=GF BM   hmmbuild  --handHMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF NE   PF18510;
#=GF NL   M9SJC9.1/1010-1167
#=GF RN   [1]
#=GF RM   28431230
#=GF RT   Structural Basis for Guide RNA Processing and Seed-Dependent DNA
#=GF RT   Targeting by CRISPR-Cas12a.
#=GF RA   Swarts DC, van der Oost J, Jinek M;
#=GF RL   Mol Cell. 2017;66:221-233.
#=GF DR   INTERPRO; IPR040852;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a RuvC nuclease domain found in type V CRISPR-associated
#=GF CC   protein Cas12a (Cpf1), used for genome editing applications.
#=GF CC   These proteins carry out endoribonuclease activity for
#=GF CC   processing its own guide RNAs and RNA-guided DNase activity for
#=GF CC   target DNA cleavage. The C-terminal region of Cas12a carries the
#=GF CC   RUVC domain, NUC domain Pfam:PF18510 and the arginine-rich
#=GF CC   bridge helix (BH). Both the NUC and BH domains are nested in the
#=GF CC   RuvC domain. Mutations in the RuvC domain impair cleavage of
#=GF CC   both strands in a target DNA duplex, while a mutation in the Nuc
#=GF CC   domain impaired target strand cleavage only.  This indicates
#=GF CC   that the DNA nuclease active sites are located at the interface
#=GF CC   of the RuvC and Nuc domains and that cleavage of the non-target
#=GF CC   DNA strand by the RuvC domain is a prerequisite for target
#=GF CC   strand cleavage by the Nuc domain [1].
#=GF SQ   29
#=GS H3NP38_9FIRM/891-1310       AC H3NP38.1
#=GS R9KJ83_9FIRM/816-1229       AC R9KJ83.1
#=GS A0A2S0VW63_9ALTE/1008-1436  AC A0A2S0VW63.1
#=GS A0A1T4KTI7_9SPIO/888-1321   AC A0A1T4KTI7.1
#=GS A0A2X4PJM6_9PORP/852-1257   AC A0A2X4PJM6.1
#=GS A0A229GIY5_9GAMM/849-1261   AC A0A229GIY5.1
#=GS R7NAK7_9FIRM/864-1304       AC R7NAK7.1
#=GS A0A3R6U2T4_9FIRM/893-1211   AC A0A3R6U2T4.1
#=GS G2Z495_FLABF/903-1318       AC G2Z495.1
#=GS A0A0D6TKF1_9FLAO/859-1272   AC A0A0D6TKF1.1
#=GS A0A3E1EYK1_9FLAO/882-1296   AC A0A3E1EYK1.1
#=GS R7NIP4_9FIRM/805-958        AC R7NIP4.1
#=GS R7NGM0_9FIRM/1-272          AC R7NGM0.1
#=GS A0A066UMX8_9GAMM/960-1373   AC A0A066UMX8.1
#=GS M9SJC9_METAX/822-1223       AC M9SJC9.1
#=GS A0A133Y4S8_9BACT/825-1239   AC A0A133Y4S8.1
#=GS A0A2P2E441_9LEPT/852-1268   AC A0A2P2E441.1
#=GS A0A0E3UUQ3_9FUSO/579-973    AC A0A0E3UUQ3.1
#=GS A0A091FHB8_9DELT/837-1250   AC A0A091FHB8.1
#=GS A0A1D9P5I8_9FIRM/896-1267   AC A0A1D9P5I8.1
#=GS A0A373ACR6_9FIRM/852-1273   AC A0A373ACR6.1
#=GS D7JGI7_9BACT/839-1259       AC D7JGI7.1
#=GS E0S4L0_BUTPB/865-1239       AC E0S4L0.1
#=GS A0A1Q2MH85_9BACT/871-1284   AC A0A1Q2MH85.1
#=GS A0A1T4JZ89_9FIRM/848-1260   AC A0A1T4JZ89.1
#=GS A0A0A7LCY1_9EURY/833-1238   AC A0A0A7LCY1.1
#=GS D8E0G1_PREBR/840-1254       AC D8E0G1.1
#=GS A0A073IR12_9BACT/848-1257   AC A0A073IR12.1
#=GS C4Z1Q1_EUBE2/854-1281       AC C4Z1Q1.1
H3NP38_9FIRM/891-1310                  .....i-KTNKNVNQIVQGMIK..DGEIKHIIGIDRGERHLLYYSVIDLEGNIVEQGSLNTLEQnrfd....nstvkVDYQNKLRTREEDRDRAR.KNWTNINKIKELKDGYLSHVVHKLSRLIIKYEAIVIMENLNQGFKRGRFKVERQVYQKFELALMNKLSALSFKEKYD.ErknlEPSGILNPIQACYPVDAYQELQGQNGIVFYLPAAYTsvidpvtgftnlfrlksinsskyeefikkfkniyfdneeedfkfifnykdfakanlvilnnikskdwkistrgerisynskkkey..........................fyvqpteflinklkelnidyenidiiplidnleekakrkilkalfdtfkysvqlrnydfendyiisptaddngnyynsneididkTNLPNNGDANGAFNIARKGLLLKDRIVN-.---SNESKV.DLKIKNEDWINFI-----is.......................................................................
R9KJ83_9FIRM/816-1229                  ....al--GENHFNRKVNRLIH..DAENMHIIGIDRGERNLIYLCMIDMKGNIVKQISLNEIISydkn....klehkRNYHQLLKTREDENKSAR.QSWQTIHTIKELKEGYLSQVIHVITDLMVEYNAIVVLEDLNFGFKQGRQKFERQVYQKFEKMLIDKLNYLVDKSKGM.D....EDGGLLHAYQLTDEFKSFKQLGKQSGFLYYIPAWNTskldpttgfvnlfytkyesvekskefinnftsilynqereyfeflfdysaftskaegsrlkwtvcskgervetyrnpkknn.................................ewdtqkidltfelkklfndysislldgdlreqmgkidkadfykkfmklfalivqmrnsderedklispvlnkygaffetgknERMPLDADANGAYNIARKGLWIIEKIKNT.-DVEQLDKV.KLTISNKEWLQYAQE---hi.......................................................................
A0A2S0VW63_9ALTE/1008-1436             ......ANGQDNINARVNQFLA..NNKKINIIGIDRGEKHLLYISVINQQGEVLHQESFNTITNsyqtangekrqvvTDYHQKLDMSEDKRDKAR.KSWSTIENIKELKAGYLSHVVHRLAQLIIEFNAIVALEDLNHGFKRGRFKIEKQVYQKFEKALIDKLSYLAFKDRTScL....ETGHYLNAFQLTSKFKGFNNLGKQSGILFYVNADYTsttdpltgyiknvyktyssvkdstefwqrfnsiryiasenrfefsydladlkqkslesktkqtplaktqwtvsshvtrsyynqqt.........................kqhelfevtariqqllskaeisyqhqndlipalascqskalhkeliwlfnsiltmrvtdsskpsatsendfilspvapyfdsrnlnKQLPENGDANGAYNIARKGIMLLERIGDF.VPEGNKKYP.DLLIRNNDWQNFVQR---pem......................................................................
A0A1T4KTI7_9SPIO/888-1321              aqgnsl-----TMNERVRKFLK..NNPEVNIIGLDRGERHLIYFSLINQKGEILKQFTFNEVERkqnd.....riikVDYHEKLDNREKERDAAR.KNWTAIGKIAELKEGYLSAVIHELTKMMIQYNAVIVMEDLNFGFKRGRFHVEKQVYQKFERMLIDKLNYLVFKDKGF.T....EPGGVLNGYQLAGQFESFQKLGKQSGFLFYVPAGYTskidpksgfadlfnlrdltnvrrkreffskfdsikydsetmsfsfafdyknfdgkgktemaktkwtvfskdkrivyfpknksysdvfptde..............lkqtfeqaeikihddenlldvimeigadlkpdekpnqnvasfwdsllrnfklilqmrnsnaqtgedyiispvkaddgtffdsrnqlslgkeAKLPIDADANGAYHIALKGLELLRRFNET.-DEIKLKKA.DMKISNADWFKFVQEKQY.........................................................................
A0A2X4PJM6_9PORP/852-1257              ...csa---GSKVNDMVNAHIR..EAKDMHVIGIDRGERNLLYICVIDSRGTILDQISLNTIND.............IDYHDLLESRDKDRQQER.RNWQTIEGIKELKQGYLSQAVHRIAELMVAYKAVVALEDLNMGFKRGRQKVESSVYQQFEKQLIDKLNYLVDKKKRP.E....DIGGLLRAYQFTAPFKSFKEMGKQNGFLFYIPAWNTsnidpttgfvnlfhaqyenvdkaksffqkfdsisynpkkdwfefafdyknftkkaegsrsmwilcthgsriknfrnsqkngq...............................wdseefalteafkslfvryeidytadlktaivdekqkdffvdllklfkltvqmrnswkekdldylispvagadgrffdtregnKSLPKDADANGAYNIALKGLWALRQIRQT.---SEGGKL.KLAISNKEWLQFVQERS-y........................................................................
A0A229GIY5_9GAMM/849-1261              ...ntg---FKAFNHQVNTTLKnaDKKDVHIIGIDRGERHLLYVSVIDGDGRIVEQRTLNDIVSisnn....gmsmsTPYHQILDNREKERLAAR.TDWGDIKNIKELKAGYLSHVVHEVVQMMLKYNAMIVLEDLNFGFKHGRFKVEKQVYQNFENALIKKLNYLVLKNADN.H....QLGSVRKALQLTNNFTDIKSIGKQTGFIFYVPAWNTskidpttgfvdllkpryenmaqaqsfisrfkkiaynhqldyfefefdyadfyqktidkkriwtlctygdvryyydhktket.................................ktvnitkelkslldkhdlsyqnghnlvdelanshdksllsgvmyllkvllalryshaqknedfilspvmnkdgvffdsrfadDVLPNNADANGAYHIALKGLWVLNQIQSA.---DNMDKI.DLSISNEQWLHFTQS---r........................................................................
R7NAK7_9FIRM/864-1304                  ...gie---DENVNSKIIEYIA..KQDNMNVIGIDRGERNLIYISVIDNKGNIIEQKSFNLVNN.............YDYKNKLKNMEKTRDNAR.KNWQEIGKIKDVKSGYLSGVISKIARMVIDYNAIIVMEDLNKGFKRGRFKVERQVYQKFENMLISKLNYLVFKERKA.D....ENGGILRGYQLTYIPKSIKNVGKQCGCIFYVPAAYTskidpatgfinifdfkkysgsginakvkdkkeflmsmnsiryinecseeyekighrelfafsfdynnfktynvsspvnewtaytygerikklykdgrwlrsevlnltenliklmeqynieykdghdiredishmdetrnadficslfeelkytvqlrnskseaedenydrlvspilnssngfydssdymenennttHTMPKDADANGAYCIALKGLYEINKIKQNwSDDKKFKEN.ELYINVTEWLDYIQNRR-f........................................................................
A0A3R6U2T4_9FIRM/893-1211              ...nyg---YNMINEETKEEIQ..EAG-KAVLSISRSIYDLLYCVLFDKNGKVIEKRSLNIING.............IDYYSLLKKIDKYRKSEKsNNWEYTTRIKDIRTHYIDLAIGEIVKYVTTYDAVIVLEKVNNSFKNKMQMIDNQLFKTFESRLELRLNDCYNKNISD.G....EAGSLTNPYQLTKQG-NLSS--VQNGYVFYLNGAYTnmcpvsgfvnffnfgninalktkk...................................................................................................................................................elllamkkisyinnsfqfefnynsmERFLKDSWKNTT-----------------.---------.------------------kevkktgyvlktdwlitavgpvtrydrekkkngyvadrtqkaydllkehncindngnvlvdtlnntslnavyd
G2Z495_FLABF/903-1318                  ......ATGGSYINQTVLEYLQ..NNPEVKIIGLDRGERHLVYLTLIDQQGNILKQESLNTITDsk.........isTPYHKLLDNKENERDLAR.KNWGTVENIKELKEGYISQVVHKIATLMLEENAIVVMEDLNFGFKRGRFKVEKQIYQKLEKMLIDKLNYLVLKDKQP.Q....ELGGLYNALQLTNKFESFQKMGKQSGFLFYVPAWNTskidpttgfvnyfytkyenvdkakaffekfeairfnaekkyfefevkkysdfnpkaegtqqawtictygerietkrqkdqnnkfvs........................tpinltekiedflgknqivygdgnciksqiaskddkaffetllywfkmtlqmrnsetrtdidylispvmndngtfynsrdyeklenPTLPKDADANGAYHIAKKGLMLLNKIDQA.---DLTKKV.DLSISNRDWLQFVQKN--k........................................................................
A0A0D6TKF1_9FLAO/859-1272              ......ATGNSYINQDVLAYLK..DNPEVNIIGLDRGERHLVYLTLIDQKGTILLQESLNVIQDek.........thTPYHTLLDNKEIARDKAR.KNWGSIESIKELKEGYISQVVHKITKMMIEHNAIVVMEDLNFGFKRGRFKVEKQIYQKLEKMLIDKLNYLVLKDKQP.H....ELGGLYNALQLTNKFESFQKMGKQSGFLFYVPAWNTskidpttgfvnyfytkyenvekaktffskfdsilynktkgyfefvvknysdfnpkaadtrqewticthgerietkrqkeqnnn..............................fvsttiqlteqfvnffekvgldlskelktqliaqneksffeelfhllkltlqmrnseshteidylispvanekgifydsrkatASLPIDADANGAYHIAKKGLWIMEQINKT.NSEDDLKKV.KLAISNREWLQYVQQVQ-k........................................................................
A0A3E1EYK1_9FLAO/882-1296              ......AKGTDYINYDVLDYLK..ENPDVKIIGLDRGERHLIYLTLIDQKGKILEQISLNEIVNkkh.......nitTSYHNLLETKEIERDKAR.KNWGTVETIKELKEGYISQVVHKISKMMIEHNAIVVMEDLNMGFKRGRFKVEKQVYQKLEKMLIDKLNYLVLKDRQP.N....EPAGIYNALQLTNKFESFQKLGKQSGFLFYVPAWNTskidpttgfvnlfhvkyesvrksqeffnkfnsikynpkeaifefdfdynefttraegtktnwtvctygdriktfrnpeklnqw.............................dnkeinittafedffgrhnitygngsdiksqlisreekdffselihlfrltlqmrnsktnseidylispvknengffydsrhadKNLPKDADANGAYHIAKKGLQWIKEIQSF.-EGNEWKKL.KLDKTNKGWLKFVQEN--q........................................................................
R7NIP4_9FIRM/805-958                   .pdhyw------LNNSVRELLK..KSNKNNIIGIDRGERNLIYVTIINSDGVIVDQINFNIIENsyng.....kkykTDYQKKLNQREEDRQKAR.KTWKTIETIKELKDGYISQVVHQICKLIVQYDAIVVMENLNGGFKRGRTKVEKQVYQKFETMLINKLNYYV------.-....------------------------------------....................................................................................................................................................................................................-----------------------------.---------.------------------vi.......................................................................
R7NGM0_9FIRM/1-272                     ......----------------..----------------------------------------.............------------------.------------------------------------------------------------------MNYYVDKGADY.K....ECGGLLKAYQLTNKFETFERIGKQSGIIFYVDPYLTskidpvtgfanllypkyetipkthnfisniddirynrsedyfefdvdydkfpqgsynyrkkwticsygnrikyykdsrnkpasrv..........................vnitekfketfnnagidfvndnikeklllvnskellksfmdtlkltvqlrnseinsdvdyiispvkdrngnfyysenykksneevPTQPQDGDANGAYNIARKGLMIINNLKNT.--DDVTNNE.LLKISKKEWLEFAQKG--dl.......................................................................
A0A066UMX8_9GAMM/960-1373              ...gmt---IKEFNKKVNQSIQ..QYDEVNVIGIDRGERHLLYLTVINSKGEILEQCSLNDITTasan....gtqmtTPYHKILDKREIERLNAR.VGWGEIETIKELKSGYLSHVVHQISQLMLKYNAIVVLEDLNFGFKRGRFKVEKQIYQNFENALIKKLNHLVLKDKAD.D....EIGSYKNALQLTNNFTDLKSIGKQTGFLFYVPAWNTskidpetgfvdllkpryeniaqsqaffgkfdkicynadkdyfefhidyakftdkaknsrqiwticshgdkryvydktanqnkg..............................aakginvndelkslfarhhinekqpnlvmdicqnndkefhkslmyllktllalrysnassdedfilspvandegvffnsaladDTQPQNADANGAYHIALKGLWLLNELKNS.---DDLNKV.KLAIDNQTWLNFAQNR--.........................................................................
M9SJC9_METAX/822-1223                  .....a-ISKPNLNKKVIDGII..DDQDLKIIGIDRGERNLIYVTMVDRKGNILYQDSLNILNG.............YDYRKALDVREYDNKEAR.RNWTKVEGIRKMKEGYLSLAVSKLADMIIENNAIIVMEDLNHGFKAGRSKIEKQVYQKFESMLINKLGYMVLKDKSI.D....QSGGALHGYQLANHVTTLASVGKQCGVIFYIPAAFTskidpttgfadlfalsnvknvasmreffskmksviydkaegkfaftfdyldynvksecgrtlwtvytvgerftysrvnr......................................eyvrkvptdiiydalqkagisvegdlrdriaesdgdtlksifyafkyaldmrvenreedyiqspvknasgeffcsknagKSLPQDSDANGAYNIALKGILQLRMLSEQyDPNAESIRL.PL-ITNKAWLTFMQSG--mk.......................................................................
A0A133Y4S8_9BACT/825-1239              ......ATQGTKVNQMVQEEVK..KSKGFHLIGIDRGERNLLYIVVINERGEIIEQCSLNKIVNtyqe.....kehtVDYKALLEKRSQSRLEER.KSWQTIENIKELKGGYLSQVVHKIAQLMIKYNAIAVLEDLNFGFIRTRKKFEFSVYQEFEKKLIDKLGYVVDKKAPI.Q....QEGGLLQAYQLTAPFKSFREMGKQNGFLFYVPAWNTsaidprtgfvnlldtryesiaktkelikklkdirynsqkdwfeidldynafgnrakgsrskwrlcsygeriehtrkqdsngqe..............................esdsmvvlteafkdvftkyqidyrenlkeqlllqsdkaffvdflsllrltlqlrnslsnslidyilspvadengeffdsrkalSNEPQDADANGAYHIALKGLWVLDKIRK-.--TEKVTPA.KLALSNQEWLSFAQEKP-f........................................................................
A0A2P2E441_9LEPT/852-1268              ..sgei----KQFNARVNSYLK..HNKDVKIIGIDRGERHLLYLSLIDQDGKILRQESLNLIKNdqn.......fkaINYQEKLHKKEIERDQAR.KSWGSIENIKELKEGYLSQVVHTISKLMVEHNAIVVLEDLNFGFKRGRQKVERQVYQKFEKMLIEKLNFLVFKDKEM.D....EPGGILKAYQLTDNFVSFEKMGKQTGFVFYVPAWNTskidpktgfvnflhlnyenvnqakeligkfdqirynqdrdwfefqvttdqfftkenapdtrtwiicstptkrfyskrtvngsvs............................tieidvnqklkelfndcnyqdgedlvdrilekdskdffskliaylriltslrqnngeqgfeerdfilspvvgsdgkffnsldasSQEPKDADANGAYHIALKGLMNLHVINET.-DDESLGKP.SWKISNKDWLNFVWQR--ps.......................................................................
A0A0E3UUQ3_9FUSO/579-973               .....k-NTNKNINKNVIDEIK..DCNEYNVIGIDRGERNLISLCIINQNGEIILQKEMNIIQSsd........kynVDYNEKLEIKSKERDNAK.KNWSEIGKIKDLKSGYLSAVVHEIVKLAIEYNAVIILEDLNNGFKNSRKKVDKQIYQKFERALIEKLQFLIFKNYDK.N....EKGGLRNAFQLTPELKNITKVASQQGIIIYTNPAYTskidpttgyaniikksnnneesivkaidkisydkekdmfyfdinlsnssfnltvknvlkkewriytngeriiykdrk.........................................yitlnitqemkdilskcgidylnidnlkqdilknklhkkvyyifelankmrnenkdvdyiispvlnkdgkffmtqeinELTPKDADLNGAYNIALKGKLMIDNLNKK.-------EK.FVFLSNEDWLNFIQG---r........................................................................
A0A091FHB8_9DELT/837-1250              ......AEGIFNMNQRVNQFLK..ANPDINIIGIDRGERHLLYYTLINQKGKILKQDTLNVIANek.........qkVDYHNLLDKKEGDRATAR.QEWGVIETIKELKEGYLSQVIHKLTDLMIENNAIIVMEDLNFGFKRGRQKVEKQVYQKFEKMLIDKLNYLVDKNKKA.N....ELGGLLNAFQLANKFESFQKMGKQNGFIFYVPAWNTsktdpatgfidflkpryenlkqakdffekfdsirlnskadyfefafdfknftgkadggrtkwtvcttnedryawnralnnnrgs...........................qekyditaelkslfdgkvdyksgkdlkqqiasqeladffrtlmkylsvtlslrhnngekgeteqdyilspvadsmgkffdsrkagDDMPKNADANGAYHIALKGLWCLEQISK-.--TDDLKKV.KLAISNKEWLEFMQTL--kg.......................................................................
A0A1D9P5I8_9FIRM/896-1267              .vsdrv---NDMLNDRVIEAMQ..D--GFNIVSVARSTKDMVYALVLDSSLKIIKELSLNVIDG.............VDYYALLHDTYLEKKENK.KLWIYDTENTELKSAYIDLAISEILKLAREYNAVIAVESISDAVKNKYSFIDNQVFKAFENRIAQRLSDLTYKDVVD.G....RPGSVSNPLQLSNNNGN----TYQDGILFFINGAYTrgidpssgftslfdfsrynsiaskrqffskmakisytgdsivfdfdyvdypvhvdtektkwqvklsgdvvvyd..................................................rekkqnkrikdvvneiiiplagktdlngniaenilnkdvpgafveelfrwfryavtgihaqvkgkdefykspvDGNEYNISNMLAFNLAKKLVFRLEYAGES.---KDF---.-----TKEWLNYMQ----a........................................................................
A0A373ACR6_9FIRM/852-1273              ......ASGKEMLNSVAQRYIA..HQNDMHVIGIDRGERNLIYVSVINMQGEIKEQKSFNIINE.............FNYKEKLKEREQSRGAAR.RNWKEIGQIKDLKEGYLSGVIHEIARMMIEYHAIIAMEDLNYGFKRGRFKVERQVYQKFENMLIQKLNYLVFKDRSA.D....EDGGVLRGYQLAYIPDSVKKLGRQCGMIFYVPAAFTskidpttgfvdifnhkayttdqakrefilsfdeicydverqlfrftfdyanfathnvtlarnnwtiytngtrtqkefvnrrvrdkedy...................npkdkmvelleseeiefksgqnllpalkkvsnakvfeelqkivrftvqlrnskseendvdydhvispvlneegkffdsskyknkeekkeSLLPVDADANGAYCIALKGLYIMQAIQKNwSEEKALSPD.VLRLNNNDWFDYIQNKR-y........................................................................
D7JGI7_9BACT/839-1259                  ....sv--GGSNINQLVKRHIR..SATDLHIIGIDRGERHLLYLTVIDSRGNIKEQFSLNEIVNeyng.....ntyrTDYHELLDTREGERTEAR.RNWQTIQNIRELKEGYLSQVIHKISELAIKYNAVIVLEDLNFGFMRSRQKVEKQVYQKFEKMLIDKLNYLVDKKKPV.A....ETGGLLRAYQLTGEFESFKTLGKQSGILFYVPAWNTskidpvtgfvnlfdthyeniekakvffdkfksirynsdkdwfefvvddytrfspkaegtrrdwtictqgkriqicrnhqrnnewe.........................gqeidltkafkehfeaygvdiskdlreqintqnkkeffeellrllrltlqmrnsmpssdidylispvandtgcffdsrkqaelkenAVLPMNADANGAYNIARKGLLAIRKMKQE.--ENDSAKI.SLAISNKEWLKFAQTKP-y........................................................................
E0S4L0_BUTPB/865-1239                  ......ARTLDYINDKVEEDTQ..DSR-MAVI-VTRNLKDLTYVAVVDEKNNVLEEKSLNEIDG.............VNYRELLKERTKIKYHDKtRLWQYDVSSKGLKEAYVELAVTQISKLATKYNAVVVVESMSSTFKDKFSFLDEQIFKAFEARLCARMSDLSFNTIKE.G....EAGSISNPIQVSNNNG----NSYQDGVIYFLNNAYTrtlcpdtgfvdvfdktrlitmqskrqffakmkdiriddgemlftfnleeyptkrlldrkewtvkiagdgsyfdk................................................dkgeyvyvndivreqiipalledkavfdgnmaekfldktaisgksveliykwfanalygiitkkdgekiyrspiTGTEIDVSKNTTYNFGKKFMF-----KQEyRGDGDFLDA.--------FLNYMQAQ--di.......................................................................
A0A1Q2MH85_9BACT/871-1284              ..agpg-----RFNDKVNKYIA..GNPDIRIIGIDRGERHLLYYSLIDQSGRIVEQGTLNQITStlnsgg.reipktTDYRGLLDTKEKERDKAR.KSWSMIENIKELKSGYLSHIVHKLAKLMVKNNAVVVLEDLNFGFKRGRFKVEKQVYQKFEKALIEKLNYLVFKDARP.A....EPGHYLNAYQLTAPLESFKKLGKQSGFIYYVPAWNTskidpvtgfvnqfyieknsmqylknffgkfdsirfnpdknyfefgfdyknfhnkaakskwticthgdkrswynrkqrkleihn..............................vtenlasllsgkginfadggsikdkilsvddasffkslafnfkltaqlrhtfedngeeidciispvaaadgtffcsetakklnMELPHDADANGAYNIARKGLMVLRQIRES.-------GK.PKPISNADWLDFAQQNE-d........................................................................
A0A1T4JZ89_9FIRM/848-1260              ......ANSKGYINDDVRNVLK..NSEDTYVIGIDRGERNLVYACVVDGNGKLVEQVPLNVIEAdn........gykTDYHKLLNDREEKRNEAR.KSWKTIGNIKELKEGYISQVVHKICQLVVKYDAVIAMEDLNSGFVNSRKKVEKQVYQKFERMLTQKLNYLVDKKLDP.N....EMGGLLNAYQLTNEATKVRN-GRQDGIIFYIPAWLTskidpttgfvnllkpkynsvsaskeffskfdeirynekenyfefsfnydnfpkcnadfkrewtvctygdrirtfrdpennnkfn............................sevvvlndefknlfvefdidytdnlkeqilamdeksfykklmgllsltlqmrnsisknvdvdylispvknsngefydsrnyditSSLPCDADSNGAYNIARKGLWAINQIKQA.---DDETKA.NISIKNSEWLQYAQN---cde......................................................................
A0A0A7LCY1_9EURY/833-1238              ......ANGKKNLNKMVIEKFL..SDEKAHIIGIDRGERNLLYYSIIDRSGKIIDQQSLNVIDG.............FDYREKLNQREIEMKDAR.QSWNAIGKIKDLKEGYLSKAVHEITKMAIQYNAIVVMEELNYGFKRGRFKVEKQIYQKFENMLIDKMNYLVFKDAPD.E....SPGGVLNAYQLTNPLESFAKLGKQTGILFYVPAAYTskidpttgfvnlfntssktnaqerkeflqkfesisysakdggifafafdyrkfgtsktdhknvwtaytngermryikekkr..................................nelfdpskeikealtssgikydggqnilpdilrsnnngliytmyssfiaaiqmrvydgkedyiispiknskgeffrtdpkrRELPIDADANGAYNIALRGELTMRAIAEK.-FDPDSEKMaKLELKHKDWFEFMQTR--gd.......................................................................
D8E0G1_PREBR/840-1254                  .....s-TGNTNINQQVIDYLR..TEDDTHIIGIDRGERHLLYLVVIDSHGKIVEQFTLNEIVNeygg.....niyrTNYHDLLDTREQNREKAR.ESWQTIENIKELKEGYISQVIHKITDLMQKYHAVVVLEDLNMGFMRGRQKVEKQVYQKFEEMLINKLNYLVNKKADQ.N....SAGGLLHAYQLTSKFESFQKLGKQSGFLFYIPAWNTskidpvtgfvnlfdtryesidkakaffgkfdsirynadkdwfefafdynnfttkaegtrtnwtictygsrirtfrnqaknsq...............................wdneeidltkaykaffakhginiydnikeaiameteksffedllhllkltlqmrnsitgtttdylispvhdskgnfydsricdNSLPANADANGAYNIARKGLMLIQQIKDS.TSSNRF--K.FSPITNKDWLIFAQEKP-y........................................................................
A0A073IR12_9BACT/848-1257              ......AQGQGNINSDVNLFLR..NNKDVNIIGIDRGERNLVYVSLIDRDGHIKLQKDFNIIGG.............MDYHAKLNQKEKERDTAR.KSWKTIGTIKELKEGYLSQVVHEIVRLAVDNNAVIVMEDLNIGFKRGRFKVEKQVYQKFEKMLIDKLNYLVFKDAGY.D....APCGILKGLQLTEKFESFTKLGKQCGIIFYIPAGYTskidpttgfvnlfnindvsskekqkdfigkldsirfdakrdmftfefdydkfrtyqtsyrkkwavwtngkrivrekdkdgkf...............................rmndrlltedmknilnkyalaykagedilpdvisrdkslaseifyvfkntlqmrnskrdtgedfiispvlnakgrffdsrktdAALPIDADANGAYHIALKGSLVLDAIDEKlKEDGRIDYK.DMAVSNPKWFEFMQTRK-f........................................................................
C4Z1Q1_EUBE2/854-1281                  .....v-TARNNVNDMVVKYIA..QNDDIHVIGIDRGERNLIYISVIDSHGNIVKQKSYNILNN.............YDYKKKLVEKEKTREYAR.KNWKSIGNIKELKEGYISGVVHEIAMLIVEYNAIIAMEDLNYGFKRGRFKVERQVYQKFESMLINKLNYFASKEKSV.D....EPGGLLKGYQLTYVPDNIKNLGKQCGVIFYVPAAFTskidpstgfisafnfksistnasrkqffmqfdeirycaekdmfsfgfdynnfdtynitmgktqwtvytngerlqsefnnarrtgktksinlt............etikllledneinyadghdiridmekmdedkkseffaqllslykltvqmrnsyteaeeqengisydkiispvindegeffdsdnykesddkeCKMPKDADANGAYCIALKGLYEVLKIKSE.WTEDGFDRN.CLKLPHAEWLDFIQNKR-y........................................................................
#=GC seq_cons                          ........ttpplNppVpchlp..ssp-hpIIGIDRGERpLlYlolIDpcGpIlcQtSLNhIss.............sDY+phLcp+Ep-RcpAR.+sWpsIpsIKELK-GYLSpVVHcIscLhlcYNAllVhEDLNhGFKRGRhKVE+QVYQKFEphLIsKLNYLVhKctss.s....EsGGlLpAaQLTsphcohpplGKQsGhlFYlPAh.TSKIDPsTGFlslFphchpssppu+phFtphpshhhpspccha.hhhs.tp.hpttttsppphhhhshssphhthpp.ppptt....................................hth.phhthhhphtthp.tp.ht..htttpppthhhthhhhhphhhthptpptppthshhhssshsspsphhpscptssshPpDADANGAYpIAhKGLhhlppIppp....sphpch.pLtIsNp-WLpFhQpt..h........................................................................
//
DBGET integrated database retrieval system