#=GF ID RuvC_1
#=GF AC PF18516.2
#=GF DE RuvC nuclease domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF06095
#=GF GA 26.20 26.20;
#=GF TC 33.30 108.10;
#=GF NC 26.10 24.00;
#=GF BM hmmbuild --handHMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF NE PF18510;
#=GF NL M9SJC9.1/1010-1167
#=GF RN [1]
#=GF RM 28431230
#=GF RT Structural Basis for Guide RNA Processing and Seed-Dependent DNA
#=GF RT Targeting by CRISPR-Cas12a.
#=GF RA Swarts DC, van der Oost J, Jinek M;
#=GF RL Mol Cell. 2017;66:221-233.
#=GF DR INTERPRO; IPR040852;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is a RuvC nuclease domain found in type V CRISPR-associated
#=GF CC protein Cas12a (Cpf1), used for genome editing applications.
#=GF CC These proteins carry out endoribonuclease activity for
#=GF CC processing its own guide RNAs and RNA-guided DNase activity for
#=GF CC target DNA cleavage. The C-terminal region of Cas12a carries the
#=GF CC RUVC domain, NUC domain Pfam:PF18510 and the arginine-rich
#=GF CC bridge helix (BH). Both the NUC and BH domains are nested in the
#=GF CC RuvC domain. Mutations in the RuvC domain impair cleavage of
#=GF CC both strands in a target DNA duplex, while a mutation in the Nuc
#=GF CC domain impaired target strand cleavage only. This indicates
#=GF CC that the DNA nuclease active sites are located at the interface
#=GF CC of the RuvC and Nuc domains and that cleavage of the non-target
#=GF CC DNA strand by the RuvC domain is a prerequisite for target
#=GF CC strand cleavage by the Nuc domain [1].
#=GF SQ 29
#=GS H3NP38_9FIRM/891-1310 AC H3NP38.1
#=GS R9KJ83_9FIRM/816-1229 AC R9KJ83.1
#=GS A0A2S0VW63_9ALTE/1008-1436 AC A0A2S0VW63.1
#=GS A0A1T4KTI7_9SPIO/888-1321 AC A0A1T4KTI7.1
#=GS A0A2X4PJM6_9PORP/852-1257 AC A0A2X4PJM6.1
#=GS A0A229GIY5_9GAMM/849-1261 AC A0A229GIY5.1
#=GS R7NAK7_9FIRM/864-1304 AC R7NAK7.1
#=GS A0A3R6U2T4_9FIRM/893-1211 AC A0A3R6U2T4.1
#=GS G2Z495_FLABF/903-1318 AC G2Z495.1
#=GS A0A0D6TKF1_9FLAO/859-1272 AC A0A0D6TKF1.1
#=GS A0A3E1EYK1_9FLAO/882-1296 AC A0A3E1EYK1.1
#=GS R7NIP4_9FIRM/805-958 AC R7NIP4.1
#=GS R7NGM0_9FIRM/1-272 AC R7NGM0.1
#=GS A0A066UMX8_9GAMM/960-1373 AC A0A066UMX8.1
#=GS M9SJC9_METAX/822-1223 AC M9SJC9.1
#=GS A0A133Y4S8_9BACT/825-1239 AC A0A133Y4S8.1
#=GS A0A2P2E441_9LEPT/852-1268 AC A0A2P2E441.1
#=GS A0A0E3UUQ3_9FUSO/579-973 AC A0A0E3UUQ3.1
#=GS A0A091FHB8_9DELT/837-1250 AC A0A091FHB8.1
#=GS A0A1D9P5I8_9FIRM/896-1267 AC A0A1D9P5I8.1
#=GS A0A373ACR6_9FIRM/852-1273 AC A0A373ACR6.1
#=GS D7JGI7_9BACT/839-1259 AC D7JGI7.1
#=GS E0S4L0_BUTPB/865-1239 AC E0S4L0.1
#=GS A0A1Q2MH85_9BACT/871-1284 AC A0A1Q2MH85.1
#=GS A0A1T4JZ89_9FIRM/848-1260 AC A0A1T4JZ89.1
#=GS A0A0A7LCY1_9EURY/833-1238 AC A0A0A7LCY1.1
#=GS D8E0G1_PREBR/840-1254 AC D8E0G1.1
#=GS A0A073IR12_9BACT/848-1257 AC A0A073IR12.1
#=GS C4Z1Q1_EUBE2/854-1281 AC C4Z1Q1.1
H3NP38_9FIRM/891-1310 .....i-KTNKNVNQIVQGMIK..DGEIKHIIGIDRGERHLLYYSVIDLEGNIVEQGSLNTLEQnrfd....nstvkVDYQNKLRTREEDRDRAR.KNWTNINKIKELKDGYLSHVVHKLSRLIIKYEAIVIMENLNQGFKRGRFKVERQVYQKFELALMNKLSALSFKEKYD.ErknlEPSGILNPIQACYPVDAYQELQGQNGIVFYLPAAYTsvidpvtgftnlfrlksinsskyeefikkfkniyfdneeedfkfifnykdfakanlvilnnikskdwkistrgerisynskkkey..........................fyvqpteflinklkelnidyenidiiplidnleekakrkilkalfdtfkysvqlrnydfendyiisptaddngnyynsneididkTNLPNNGDANGAFNIARKGLLLKDRIVN-.---SNESKV.DLKIKNEDWINFI-----is.......................................................................
R9KJ83_9FIRM/816-1229 ....al--GENHFNRKVNRLIH..DAENMHIIGIDRGERNLIYLCMIDMKGNIVKQISLNEIISydkn....klehkRNYHQLLKTREDENKSAR.QSWQTIHTIKELKEGYLSQVIHVITDLMVEYNAIVVLEDLNFGFKQGRQKFERQVYQKFEKMLIDKLNYLVDKSKGM.D....EDGGLLHAYQLTDEFKSFKQLGKQSGFLYYIPAWNTskldpttgfvnlfytkyesvekskefinnftsilynqereyfeflfdysaftskaegsrlkwtvcskgervetyrnpkknn.................................ewdtqkidltfelkklfndysislldgdlreqmgkidkadfykkfmklfalivqmrnsderedklispvlnkygaffetgknERMPLDADANGAYNIARKGLWIIEKIKNT.-DVEQLDKV.KLTISNKEWLQYAQE---hi.......................................................................
A0A2S0VW63_9ALTE/1008-1436 ......ANGQDNINARVNQFLA..NNKKINIIGIDRGEKHLLYISVINQQGEVLHQESFNTITNsyqtangekrqvvTDYHQKLDMSEDKRDKAR.KSWSTIENIKELKAGYLSHVVHRLAQLIIEFNAIVALEDLNHGFKRGRFKIEKQVYQKFEKALIDKLSYLAFKDRTScL....ETGHYLNAFQLTSKFKGFNNLGKQSGILFYVNADYTsttdpltgyiknvyktyssvkdstefwqrfnsiryiasenrfefsydladlkqkslesktkqtplaktqwtvsshvtrsyynqqt.........................kqhelfevtariqqllskaeisyqhqndlipalascqskalhkeliwlfnsiltmrvtdsskpsatsendfilspvapyfdsrnlnKQLPENGDANGAYNIARKGIMLLERIGDF.VPEGNKKYP.DLLIRNNDWQNFVQR---pem......................................................................
A0A1T4KTI7_9SPIO/888-1321 aqgnsl-----TMNERVRKFLK..NNPEVNIIGLDRGERHLIYFSLINQKGEILKQFTFNEVERkqnd.....riikVDYHEKLDNREKERDAAR.KNWTAIGKIAELKEGYLSAVIHELTKMMIQYNAVIVMEDLNFGFKRGRFHVEKQVYQKFERMLIDKLNYLVFKDKGF.T....EPGGVLNGYQLAGQFESFQKLGKQSGFLFYVPAGYTskidpksgfadlfnlrdltnvrrkreffskfdsikydsetmsfsfafdyknfdgkgktemaktkwtvfskdkrivyfpknksysdvfptde..............lkqtfeqaeikihddenlldvimeigadlkpdekpnqnvasfwdsllrnfklilqmrnsnaqtgedyiispvkaddgtffdsrnqlslgkeAKLPIDADANGAYHIALKGLELLRRFNET.-DEIKLKKA.DMKISNADWFKFVQEKQY.........................................................................
A0A2X4PJM6_9PORP/852-1257 ...csa---GSKVNDMVNAHIR..EAKDMHVIGIDRGERNLLYICVIDSRGTILDQISLNTIND.............IDYHDLLESRDKDRQQER.RNWQTIEGIKELKQGYLSQAVHRIAELMVAYKAVVALEDLNMGFKRGRQKVESSVYQQFEKQLIDKLNYLVDKKKRP.E....DIGGLLRAYQFTAPFKSFKEMGKQNGFLFYIPAWNTsnidpttgfvnlfhaqyenvdkaksffqkfdsisynpkkdwfefafdyknftkkaegsrsmwilcthgsriknfrnsqkngq...............................wdseefalteafkslfvryeidytadlktaivdekqkdffvdllklfkltvqmrnswkekdldylispvagadgrffdtregnKSLPKDADANGAYNIALKGLWALRQIRQT.---SEGGKL.KLAISNKEWLQFVQERS-y........................................................................
A0A229GIY5_9GAMM/849-1261 ...ntg---FKAFNHQVNTTLKnaDKKDVHIIGIDRGERHLLYVSVIDGDGRIVEQRTLNDIVSisnn....gmsmsTPYHQILDNREKERLAAR.TDWGDIKNIKELKAGYLSHVVHEVVQMMLKYNAMIVLEDLNFGFKHGRFKVEKQVYQNFENALIKKLNYLVLKNADN.H....QLGSVRKALQLTNNFTDIKSIGKQTGFIFYVPAWNTskidpttgfvdllkpryenmaqaqsfisrfkkiaynhqldyfefefdyadfyqktidkkriwtlctygdvryyydhktket.................................ktvnitkelkslldkhdlsyqnghnlvdelanshdksllsgvmyllkvllalryshaqknedfilspvmnkdgvffdsrfadDVLPNNADANGAYHIALKGLWVLNQIQSA.---DNMDKI.DLSISNEQWLHFTQS---r........................................................................
R7NAK7_9FIRM/864-1304 ...gie---DENVNSKIIEYIA..KQDNMNVIGIDRGERNLIYISVIDNKGNIIEQKSFNLVNN.............YDYKNKLKNMEKTRDNAR.KNWQEIGKIKDVKSGYLSGVISKIARMVIDYNAIIVMEDLNKGFKRGRFKVERQVYQKFENMLISKLNYLVFKERKA.D....ENGGILRGYQLTYIPKSIKNVGKQCGCIFYVPAAYTskidpatgfinifdfkkysgsginakvkdkkeflmsmnsiryinecseeyekighrelfafsfdynnfktynvsspvnewtaytygerikklykdgrwlrsevlnltenliklmeqynieykdghdiredishmdetrnadficslfeelkytvqlrnskseaedenydrlvspilnssngfydssdymenennttHTMPKDADANGAYCIALKGLYEINKIKQNwSDDKKFKEN.ELYINVTEWLDYIQNRR-f........................................................................
A0A3R6U2T4_9FIRM/893-1211 ...nyg---YNMINEETKEEIQ..EAG-KAVLSISRSIYDLLYCVLFDKNGKVIEKRSLNIING.............IDYYSLLKKIDKYRKSEKsNNWEYTTRIKDIRTHYIDLAIGEIVKYVTTYDAVIVLEKVNNSFKNKMQMIDNQLFKTFESRLELRLNDCYNKNISD.G....EAGSLTNPYQLTKQG-NLSS--VQNGYVFYLNGAYTnmcpvsgfvnffnfgninalktkk...................................................................................................................................................elllamkkisyinnsfqfefnynsmERFLKDSWKNTT-----------------.---------.------------------kevkktgyvlktdwlitavgpvtrydrekkkngyvadrtqkaydllkehncindngnvlvdtlnntslnavyd
G2Z495_FLABF/903-1318 ......ATGGSYINQTVLEYLQ..NNPEVKIIGLDRGERHLVYLTLIDQQGNILKQESLNTITDsk.........isTPYHKLLDNKENERDLAR.KNWGTVENIKELKEGYISQVVHKIATLMLEENAIVVMEDLNFGFKRGRFKVEKQIYQKLEKMLIDKLNYLVLKDKQP.Q....ELGGLYNALQLTNKFESFQKMGKQSGFLFYVPAWNTskidpttgfvnyfytkyenvdkakaffekfeairfnaekkyfefevkkysdfnpkaegtqqawtictygerietkrqkdqnnkfvs........................tpinltekiedflgknqivygdgnciksqiaskddkaffetllywfkmtlqmrnsetrtdidylispvmndngtfynsrdyeklenPTLPKDADANGAYHIAKKGLMLLNKIDQA.---DLTKKV.DLSISNRDWLQFVQKN--k........................................................................
A0A0D6TKF1_9FLAO/859-1272 ......ATGNSYINQDVLAYLK..DNPEVNIIGLDRGERHLVYLTLIDQKGTILLQESLNVIQDek.........thTPYHTLLDNKEIARDKAR.KNWGSIESIKELKEGYISQVVHKITKMMIEHNAIVVMEDLNFGFKRGRFKVEKQIYQKLEKMLIDKLNYLVLKDKQP.H....ELGGLYNALQLTNKFESFQKMGKQSGFLFYVPAWNTskidpttgfvnyfytkyenvekaktffskfdsilynktkgyfefvvknysdfnpkaadtrqewticthgerietkrqkeqnnn..............................fvsttiqlteqfvnffekvgldlskelktqliaqneksffeelfhllkltlqmrnseshteidylispvanekgifydsrkatASLPIDADANGAYHIAKKGLWIMEQINKT.NSEDDLKKV.KLAISNREWLQYVQQVQ-k........................................................................
A0A3E1EYK1_9FLAO/882-1296 ......AKGTDYINYDVLDYLK..ENPDVKIIGLDRGERHLIYLTLIDQKGKILEQISLNEIVNkkh.......nitTSYHNLLETKEIERDKAR.KNWGTVETIKELKEGYISQVVHKISKMMIEHNAIVVMEDLNMGFKRGRFKVEKQVYQKLEKMLIDKLNYLVLKDRQP.N....EPAGIYNALQLTNKFESFQKLGKQSGFLFYVPAWNTskidpttgfvnlfhvkyesvrksqeffnkfnsikynpkeaifefdfdynefttraegtktnwtvctygdriktfrnpeklnqw.............................dnkeinittafedffgrhnitygngsdiksqlisreekdffselihlfrltlqmrnsktnseidylispvknengffydsrhadKNLPKDADANGAYHIAKKGLQWIKEIQSF.-EGNEWKKL.KLDKTNKGWLKFVQEN--q........................................................................
R7NIP4_9FIRM/805-958 .pdhyw------LNNSVRELLK..KSNKNNIIGIDRGERNLIYVTIINSDGVIVDQINFNIIENsyng.....kkykTDYQKKLNQREEDRQKAR.KTWKTIETIKELKDGYISQVVHQICKLIVQYDAIVVMENLNGGFKRGRTKVEKQVYQKFETMLINKLNYYV------.-....------------------------------------....................................................................................................................................................................................................-----------------------------.---------.------------------vi.......................................................................
R7NGM0_9FIRM/1-272 ......----------------..----------------------------------------.............------------------.------------------------------------------------------------------MNYYVDKGADY.K....ECGGLLKAYQLTNKFETFERIGKQSGIIFYVDPYLTskidpvtgfanllypkyetipkthnfisniddirynrsedyfefdvdydkfpqgsynyrkkwticsygnrikyykdsrnkpasrv..........................vnitekfketfnnagidfvndnikeklllvnskellksfmdtlkltvqlrnseinsdvdyiispvkdrngnfyysenykksneevPTQPQDGDANGAYNIARKGLMIINNLKNT.--DDVTNNE.LLKISKKEWLEFAQKG--dl.......................................................................
A0A066UMX8_9GAMM/960-1373 ...gmt---IKEFNKKVNQSIQ..QYDEVNVIGIDRGERHLLYLTVINSKGEILEQCSLNDITTasan....gtqmtTPYHKILDKREIERLNAR.VGWGEIETIKELKSGYLSHVVHQISQLMLKYNAIVVLEDLNFGFKRGRFKVEKQIYQNFENALIKKLNHLVLKDKAD.D....EIGSYKNALQLTNNFTDLKSIGKQTGFLFYVPAWNTskidpetgfvdllkpryeniaqsqaffgkfdkicynadkdyfefhidyakftdkaknsrqiwticshgdkryvydktanqnkg..............................aakginvndelkslfarhhinekqpnlvmdicqnndkefhkslmyllktllalrysnassdedfilspvandegvffnsaladDTQPQNADANGAYHIALKGLWLLNELKNS.---DDLNKV.KLAIDNQTWLNFAQNR--.........................................................................
M9SJC9_METAX/822-1223 .....a-ISKPNLNKKVIDGII..DDQDLKIIGIDRGERNLIYVTMVDRKGNILYQDSLNILNG.............YDYRKALDVREYDNKEAR.RNWTKVEGIRKMKEGYLSLAVSKLADMIIENNAIIVMEDLNHGFKAGRSKIEKQVYQKFESMLINKLGYMVLKDKSI.D....QSGGALHGYQLANHVTTLASVGKQCGVIFYIPAAFTskidpttgfadlfalsnvknvasmreffskmksviydkaegkfaftfdyldynvksecgrtlwtvytvgerftysrvnr......................................eyvrkvptdiiydalqkagisvegdlrdriaesdgdtlksifyafkyaldmrvenreedyiqspvknasgeffcsknagKSLPQDSDANGAYNIALKGILQLRMLSEQyDPNAESIRL.PL-ITNKAWLTFMQSG--mk.......................................................................
A0A133Y4S8_9BACT/825-1239 ......ATQGTKVNQMVQEEVK..KSKGFHLIGIDRGERNLLYIVVINERGEIIEQCSLNKIVNtyqe.....kehtVDYKALLEKRSQSRLEER.KSWQTIENIKELKGGYLSQVVHKIAQLMIKYNAIAVLEDLNFGFIRTRKKFEFSVYQEFEKKLIDKLGYVVDKKAPI.Q....QEGGLLQAYQLTAPFKSFREMGKQNGFLFYVPAWNTsaidprtgfvnlldtryesiaktkelikklkdirynsqkdwfeidldynafgnrakgsrskwrlcsygeriehtrkqdsngqe..............................esdsmvvlteafkdvftkyqidyrenlkeqlllqsdkaffvdflsllrltlqlrnslsnslidyilspvadengeffdsrkalSNEPQDADANGAYHIALKGLWVLDKIRK-.--TEKVTPA.KLALSNQEWLSFAQEKP-f........................................................................
A0A2P2E441_9LEPT/852-1268 ..sgei----KQFNARVNSYLK..HNKDVKIIGIDRGERHLLYLSLIDQDGKILRQESLNLIKNdqn.......fkaINYQEKLHKKEIERDQAR.KSWGSIENIKELKEGYLSQVVHTISKLMVEHNAIVVLEDLNFGFKRGRQKVERQVYQKFEKMLIEKLNFLVFKDKEM.D....EPGGILKAYQLTDNFVSFEKMGKQTGFVFYVPAWNTskidpktgfvnflhlnyenvnqakeligkfdqirynqdrdwfefqvttdqfftkenapdtrtwiicstptkrfyskrtvngsvs............................tieidvnqklkelfndcnyqdgedlvdrilekdskdffskliaylriltslrqnngeqgfeerdfilspvvgsdgkffnsldasSQEPKDADANGAYHIALKGLMNLHVINET.-DDESLGKP.SWKISNKDWLNFVWQR--ps.......................................................................
A0A0E3UUQ3_9FUSO/579-973 .....k-NTNKNINKNVIDEIK..DCNEYNVIGIDRGERNLISLCIINQNGEIILQKEMNIIQSsd........kynVDYNEKLEIKSKERDNAK.KNWSEIGKIKDLKSGYLSAVVHEIVKLAIEYNAVIILEDLNNGFKNSRKKVDKQIYQKFERALIEKLQFLIFKNYDK.N....EKGGLRNAFQLTPELKNITKVASQQGIIIYTNPAYTskidpttgyaniikksnnneesivkaidkisydkekdmfyfdinlsnssfnltvknvlkkewriytngeriiykdrk.........................................yitlnitqemkdilskcgidylnidnlkqdilknklhkkvyyifelankmrnenkdvdyiispvlnkdgkffmtqeinELTPKDADLNGAYNIALKGKLMIDNLNKK.-------EK.FVFLSNEDWLNFIQG---r........................................................................
A0A091FHB8_9DELT/837-1250 ......AEGIFNMNQRVNQFLK..ANPDINIIGIDRGERHLLYYTLINQKGKILKQDTLNVIANek.........qkVDYHNLLDKKEGDRATAR.QEWGVIETIKELKEGYLSQVIHKLTDLMIENNAIIVMEDLNFGFKRGRQKVEKQVYQKFEKMLIDKLNYLVDKNKKA.N....ELGGLLNAFQLANKFESFQKMGKQNGFIFYVPAWNTsktdpatgfidflkpryenlkqakdffekfdsirlnskadyfefafdfknftgkadggrtkwtvcttnedryawnralnnnrgs...........................qekyditaelkslfdgkvdyksgkdlkqqiasqeladffrtlmkylsvtlslrhnngekgeteqdyilspvadsmgkffdsrkagDDMPKNADANGAYHIALKGLWCLEQISK-.--TDDLKKV.KLAISNKEWLEFMQTL--kg.......................................................................
A0A1D9P5I8_9FIRM/896-1267 .vsdrv---NDMLNDRVIEAMQ..D--GFNIVSVARSTKDMVYALVLDSSLKIIKELSLNVIDG.............VDYYALLHDTYLEKKENK.KLWIYDTENTELKSAYIDLAISEILKLAREYNAVIAVESISDAVKNKYSFIDNQVFKAFENRIAQRLSDLTYKDVVD.G....RPGSVSNPLQLSNNNGN----TYQDGILFFINGAYTrgidpssgftslfdfsrynsiaskrqffskmakisytgdsivfdfdyvdypvhvdtektkwqvklsgdvvvyd..................................................rekkqnkrikdvvneiiiplagktdlngniaenilnkdvpgafveelfrwfryavtgihaqvkgkdefykspvDGNEYNISNMLAFNLAKKLVFRLEYAGES.---KDF---.-----TKEWLNYMQ----a........................................................................
A0A373ACR6_9FIRM/852-1273 ......ASGKEMLNSVAQRYIA..HQNDMHVIGIDRGERNLIYVSVINMQGEIKEQKSFNIINE.............FNYKEKLKEREQSRGAAR.RNWKEIGQIKDLKEGYLSGVIHEIARMMIEYHAIIAMEDLNYGFKRGRFKVERQVYQKFENMLIQKLNYLVFKDRSA.D....EDGGVLRGYQLAYIPDSVKKLGRQCGMIFYVPAAFTskidpttgfvdifnhkayttdqakrefilsfdeicydverqlfrftfdyanfathnvtlarnnwtiytngtrtqkefvnrrvrdkedy...................npkdkmvelleseeiefksgqnllpalkkvsnakvfeelqkivrftvqlrnskseendvdydhvispvlneegkffdsskyknkeekkeSLLPVDADANGAYCIALKGLYIMQAIQKNwSEEKALSPD.VLRLNNNDWFDYIQNKR-y........................................................................
D7JGI7_9BACT/839-1259 ....sv--GGSNINQLVKRHIR..SATDLHIIGIDRGERHLLYLTVIDSRGNIKEQFSLNEIVNeyng.....ntyrTDYHELLDTREGERTEAR.RNWQTIQNIRELKEGYLSQVIHKISELAIKYNAVIVLEDLNFGFMRSRQKVEKQVYQKFEKMLIDKLNYLVDKKKPV.A....ETGGLLRAYQLTGEFESFKTLGKQSGILFYVPAWNTskidpvtgfvnlfdthyeniekakvffdkfksirynsdkdwfefvvddytrfspkaegtrrdwtictqgkriqicrnhqrnnewe.........................gqeidltkafkehfeaygvdiskdlreqintqnkkeffeellrllrltlqmrnsmpssdidylispvandtgcffdsrkqaelkenAVLPMNADANGAYNIARKGLLAIRKMKQE.--ENDSAKI.SLAISNKEWLKFAQTKP-y........................................................................
E0S4L0_BUTPB/865-1239 ......ARTLDYINDKVEEDTQ..DSR-MAVI-VTRNLKDLTYVAVVDEKNNVLEEKSLNEIDG.............VNYRELLKERTKIKYHDKtRLWQYDVSSKGLKEAYVELAVTQISKLATKYNAVVVVESMSSTFKDKFSFLDEQIFKAFEARLCARMSDLSFNTIKE.G....EAGSISNPIQVSNNNG----NSYQDGVIYFLNNAYTrtlcpdtgfvdvfdktrlitmqskrqffakmkdiriddgemlftfnleeyptkrlldrkewtvkiagdgsyfdk................................................dkgeyvyvndivreqiipalledkavfdgnmaekfldktaisgksveliykwfanalygiitkkdgekiyrspiTGTEIDVSKNTTYNFGKKFMF-----KQEyRGDGDFLDA.--------FLNYMQAQ--di.......................................................................
A0A1Q2MH85_9BACT/871-1284 ..agpg-----RFNDKVNKYIA..GNPDIRIIGIDRGERHLLYYSLIDQSGRIVEQGTLNQITStlnsgg.reipktTDYRGLLDTKEKERDKAR.KSWSMIENIKELKSGYLSHIVHKLAKLMVKNNAVVVLEDLNFGFKRGRFKVEKQVYQKFEKALIEKLNYLVFKDARP.A....EPGHYLNAYQLTAPLESFKKLGKQSGFIYYVPAWNTskidpvtgfvnqfyieknsmqylknffgkfdsirfnpdknyfefgfdyknfhnkaakskwticthgdkrswynrkqrkleihn..............................vtenlasllsgkginfadggsikdkilsvddasffkslafnfkltaqlrhtfedngeeidciispvaaadgtffcsetakklnMELPHDADANGAYNIARKGLMVLRQIRES.-------GK.PKPISNADWLDFAQQNE-d........................................................................
A0A1T4JZ89_9FIRM/848-1260 ......ANSKGYINDDVRNVLK..NSEDTYVIGIDRGERNLVYACVVDGNGKLVEQVPLNVIEAdn........gykTDYHKLLNDREEKRNEAR.KSWKTIGNIKELKEGYISQVVHKICQLVVKYDAVIAMEDLNSGFVNSRKKVEKQVYQKFERMLTQKLNYLVDKKLDP.N....EMGGLLNAYQLTNEATKVRN-GRQDGIIFYIPAWLTskidpttgfvnllkpkynsvsaskeffskfdeirynekenyfefsfnydnfpkcnadfkrewtvctygdrirtfrdpennnkfn............................sevvvlndefknlfvefdidytdnlkeqilamdeksfykklmgllsltlqmrnsisknvdvdylispvknsngefydsrnyditSSLPCDADSNGAYNIARKGLWAINQIKQA.---DDETKA.NISIKNSEWLQYAQN---cde......................................................................
A0A0A7LCY1_9EURY/833-1238 ......ANGKKNLNKMVIEKFL..SDEKAHIIGIDRGERNLLYYSIIDRSGKIIDQQSLNVIDG.............FDYREKLNQREIEMKDAR.QSWNAIGKIKDLKEGYLSKAVHEITKMAIQYNAIVVMEELNYGFKRGRFKVEKQIYQKFENMLIDKMNYLVFKDAPD.E....SPGGVLNAYQLTNPLESFAKLGKQTGILFYVPAAYTskidpttgfvnlfntssktnaqerkeflqkfesisysakdggifafafdyrkfgtsktdhknvwtaytngermryikekkr..................................nelfdpskeikealtssgikydggqnilpdilrsnnngliytmyssfiaaiqmrvydgkedyiispiknskgeffrtdpkrRELPIDADANGAYNIALRGELTMRAIAEK.-FDPDSEKMaKLELKHKDWFEFMQTR--gd.......................................................................
D8E0G1_PREBR/840-1254 .....s-TGNTNINQQVIDYLR..TEDDTHIIGIDRGERHLLYLVVIDSHGKIVEQFTLNEIVNeygg.....niyrTNYHDLLDTREQNREKAR.ESWQTIENIKELKEGYISQVIHKITDLMQKYHAVVVLEDLNMGFMRGRQKVEKQVYQKFEEMLINKLNYLVNKKADQ.N....SAGGLLHAYQLTSKFESFQKLGKQSGFLFYIPAWNTskidpvtgfvnlfdtryesidkakaffgkfdsirynadkdwfefafdynnfttkaegtrtnwtictygsrirtfrnqaknsq...............................wdneeidltkaykaffakhginiydnikeaiameteksffedllhllkltlqmrnsitgtttdylispvhdskgnfydsricdNSLPANADANGAYNIARKGLMLIQQIKDS.TSSNRF--K.FSPITNKDWLIFAQEKP-y........................................................................
A0A073IR12_9BACT/848-1257 ......AQGQGNINSDVNLFLR..NNKDVNIIGIDRGERNLVYVSLIDRDGHIKLQKDFNIIGG.............MDYHAKLNQKEKERDTAR.KSWKTIGTIKELKEGYLSQVVHEIVRLAVDNNAVIVMEDLNIGFKRGRFKVEKQVYQKFEKMLIDKLNYLVFKDAGY.D....APCGILKGLQLTEKFESFTKLGKQCGIIFYIPAGYTskidpttgfvnlfnindvsskekqkdfigkldsirfdakrdmftfefdydkfrtyqtsyrkkwavwtngkrivrekdkdgkf...............................rmndrlltedmknilnkyalaykagedilpdvisrdkslaseifyvfkntlqmrnskrdtgedfiispvlnakgrffdsrktdAALPIDADANGAYHIALKGSLVLDAIDEKlKEDGRIDYK.DMAVSNPKWFEFMQTRK-f........................................................................
C4Z1Q1_EUBE2/854-1281 .....v-TARNNVNDMVVKYIA..QNDDIHVIGIDRGERNLIYISVIDSHGNIVKQKSYNILNN.............YDYKKKLVEKEKTREYAR.KNWKSIGNIKELKEGYISGVVHEIAMLIVEYNAIIAMEDLNYGFKRGRFKVERQVYQKFESMLINKLNYFASKEKSV.D....EPGGLLKGYQLTYVPDNIKNLGKQCGVIFYVPAAFTskidpstgfisafnfksistnasrkqffmqfdeirycaekdmfsfgfdynnfdtynitmgktqwtvytngerlqsefnnarrtgktksinlt............etikllledneinyadghdiridmekmdedkkseffaqllslykltvqmrnsyteaeeqengisydkiispvindegeffdsdnykesddkeCKMPKDADANGAYCIALKGLYEVLKIKSE.WTEDGFDRN.CLKLPHAEWLDFIQNKR-y........................................................................
#=GC seq_cons ........ttpplNppVpchlp..ssp-hpIIGIDRGERpLlYlolIDpcGpIlcQtSLNhIss.............sDY+phLcp+Ep-RcpAR.+sWpsIpsIKELK-GYLSpVVHcIscLhlcYNAllVhEDLNhGFKRGRhKVE+QVYQKFEphLIsKLNYLVhKctss.s....EsGGlLpAaQLTsphcohpplGKQsGhlFYlPAh.TSKIDPsTGFlslFphchpssppu+phFtphpshhhpspccha.hhhs.tp.hpttttsppphhhhshssphhthpp.ppptt....................................hth.phhthhhphtthp.tp.ht..htttpppthhhthhhhhphhhthptpptppthshhhssshsspsphhpscptssshPpDADANGAYpIAhKGLhhlppIppp....sphpch.pLtIsNp-WLpFhQpt..h........................................................................
//
