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Database: Pfam
Entry: SAM_Ste50p
LinkDB: SAM_Ste50p
Original site: SAM_Ste50p 
#=GF ID   SAM_Ste50p
#=GF AC   PF09235.11
#=GF DE   Ste50p, sterile alpha motif
#=GF PI   Ste50p-SAM;
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1uqv
#=GF GA   20.90 20.90;
#=GF TC   20.90 20.90;
#=GF NC   20.80 20.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Sterile_alpha_motif
#=GF RN   [1]
#=GF RM   14573615
#=GF RT   Structure of the sterile alpha motif (SAM) domain of the
#=GF RT   Saccharomyces cerevisiae mitogen-activated protein kinase
#=GF RT   pathway-modulating protein STE50 and analysis of its interaction
#=GF RT   with the STE11 SAM. 
#=GF RA   Grimshaw SJ, Mott HR, Stott KM, Nielsen PR, Evetts KA, Hopkins
#=GF RA   LJ, Nietlispach D, Owen D; 
#=GF RL   J Biol Chem. 2004;279:2192-2201.
#=GF DR   INTERPRO; IPR015316;
#=GF DR   SCOP; 1uqv; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The fungal Ste50p SAM domain consists of five helices, which
#=GF CC   form a compact, globular fold. It is required for mediation of
#=GF CC   homodimerisation and heterodimerisation (and in some cases
#=GF CC   oligomerisation) of the protein [1].
#=GF SQ   30
#=GS A0A1G4MGI2_LACFM/14-90      AC A0A1G4MGI2.1
#=GS W0T6F9_KLUMD/2-76           AC W0T6F9.1
#=GS A0A1I7U3F1_9PELO/359-438    AC A0A1I7U3F1.1
#=GS A8XQJ2_CAEBR/129-189        AC A8XQJ2.2
#=GS A7TFA3_VANPO/13-87          AC A7TFA3.1
#=GS A0A261BZX2_9PELO/1029-1105  AC A0A261BZX2.1
#=GS A0A109UVV4_9SACH/69-132     AC A0A109UVV4.1
#=GS A0A1G4KET0_9SACH/14-91      AC A0A1G4KET0.1
#=GS G0W313_NAUDC/65-140         AC G0W313.1
#=GS G8ZQR2_TORDC/22-96          AC G8ZQR2.1
#=GS STE50_YEAST/30-104          AC P25344.1
#=GS STE50_YEAST/30-104          DR PDB; 1UQV A; 30-104;
#=GS STE50_YEAST/30-104          DR PDB; 1Z1V A; 33-102;
#=GS A0A0C7NF16_9SACH/15-106     AC A0A0C7NF16.1
#=GS A0A2G5TZE9_9PELO/57-104     AC A0A2G5TZE9.1
#=GS I2GWM0_TETBL/2-68           AC I2GWM0.1
#=GS H2ATI6_KAZAF/12-86          AC H2ATI6.1
#=GS G8BQ67_TETPH/17-92          AC G8BQ67.1
#=GS A0A1X7R366_9SACH/47-121     AC A0A1X7R366.1
#=GS G0VAU1_NAUCC/37-112         AC G0VAU1.1
#=GS Q6CUY2_KLULA/2-76           AC Q6CUY2.1
#=GS Q6FX88_CANGA/16-90          AC Q6FX88.1
#=GS A0A261C0V1_9PELO/1043-1119  AC A0A261C0V1.1
#=GS J7RW15_KAZNA/42-126         AC J7RW15.1
#=GS Q751W9_ASHGO/75-129         AC Q751W9.1
#=GS S6EX59_ZYGB2/29-106         AC S6EX59.1
#=GS C5DZ24_ZYGRC/18-92          AC C5DZ24.1
#=GS J4TXQ0_SACK1/30-104         AC J4TXQ0.1
#=GS A0A1G4JZE5_9SACH/20-96      AC A0A1G4JZE5.1
#=GS G8JM97_ERECY/97-150         AC G8JM97.1
#=GS C5DK31_LACTC/14-90          AC C5DK31.1
#=GS A0A1G4JVT6_9SACH/10-88      AC A0A1G4JVT6.1
A0A1G4MGI2_LACFM/14-90                 ...........................................d-GYVKWSVKEVGEWCAEK.LQLDG.E..D.L.V..KLQe..cIEEQGIDGDILDELSLQD..CKMIT..G.GN..........VG.RAVRLKVELNRLREKK-h........................
W0T6F9_KLUMD/2-76                      ............................................SGTNEWSTEEVCKKLKAE.LELDD.A..E.T.Y..ILD...rIRENKITGSTLSEITLAD..CKELC..P.DN..........VS.-AVRLKTCINKFVDAEE.........................
A0A1I7U3F1_9PELO/359-438               ............................................EDVHQWSEHHTSHWVETV.LGRVA.N..D.KkF..LDRvnaaVFRNRITGARLLEMTQND..LEHLG..V.HK..........VG.SRIELMKMIRKLGDTQ-k........................
A8XQJ2_CAEBR/129-189                   ............................................DDFWHWSKETVLSWMALV.IPQEH.Q..N.G.V..IGR....LREVDLDGGWLPELA---..-----..-.--..........--.-----------------keqtiknalnltdtqh.........
A7TFA3_VANPO/13-87                     ...........................................v-NCNSWTTQEVVAWCMSS.LGIPQ.D..S.T.L..CNN....LHQHNITGDLLEELTLED..CKELC..G.ND..........RG.LALRFKVLLNKLFESKE.........................
A0A261BZX2_9PELO/1029-1105             ...........................................h-DYYNWKSADLAAWMKSV.LSLDD.R..D.P.L..LQK....MIDEDMDGLVLEEFLRDEsvCITTL..G.VN..........TG.RSIKIKGAIIKVVN---nra......................
A0A109UVV4_9SACH/69-132                ...........................kdksafrvldnvrtnik------------------.-----.-..-.-.-..-TT....FHEHKISGEILPYLSLEN..CKLLF..S.GE..........VR.LAVKFKISLNKLTD---kld......................
A0A1G4KET0_9SACH/14-91                 ............................................EDVTQWGIEEVLIWCEQK.VRFGS.D..A.V.LdqVRD...sFRENEIDGASLLELDLND..CKQLT..D.NN..........SK.LAVQLKLEINRLKH---qkr......................
G0W313_NAUDC/65-140                    ...........................................q-SFMEWSVNDVVKWCFKS.LSLNDiN..D.P.L..IKN....LVDHDISGDVLDELDIND..CKDLC..D.HD..........NK.KAIKLQLAFNKLTDTH-p........................
G8ZQR2_TORDC/22-96                     ............................................DDFTNWTINEVVAWCTSS.LEITE.E..D.L.L..VEK....IRSNEITGELLPELTFED..CKELC..G.GD..........LS.KSIRLKVLLNKLQDD--ad.......................
STE50_YEAST/30-104                     ............................................EDFSQWSVDDVITWCIST.LEVEE.T..D.P.L..CQR....LRENDIVGDLLPELCLQD..CQDLC..D.GD..........LN.KAIKFKILINKMRDSKL.........................
#=GR STE50_YEAST/30-104          SS    ............................................XXTTT--HHHHHHHHHHH.HSS-T.T..S.C.H..HHH....HHHTT--CCCHHHHHHHH..HHHCT..T.S-..........HH.HHHHHHHHHHHHHH-XS.........................
A0A0C7NF16_9SACH/15-106                edvalwgveevliwieqiignfgvenaggegkenakdgpnlakv------------------.-----.-..-.-.-..-QE...nFRENAIDGASLLELDLDD..CKQLM..E.ND..........AK.FAVHLKLEINILR----tqkg.....................
A0A2G5TZE9_9PELO/57-104                ...........................................v-NFQLWSHDQVIVWSKKV.FPGAA.G..T.P.T..IQK....IRNTGIAGDILAEVA---..-----..-.--..........--.-----------------sdp......................
I2GWM0_TETBL/2-68                      .........................................mdy---ENWSIEETSIWADK-.--FEL.G..D.-.-..--K....FLEHGIDGSLLKELEMND..CKEIC..G.GD..........KK.KAVMLKMNLNQLVD---dg.......................
H2ATI6_KAZAF/12-86                     ...........................................g-DYANWTVDEVVSWCKST.LKLPD.D..N.S.L..CLS....LVENDVSGSILKDLTLDD..CKDLC..D.SN..........LK.LAIKLKISINKLNDTS-a........................
G8BQ67_TETPH/17-92                     ...........................................v-NCSKWSAEDVASWCVST.LDIDN.E..S.E.L..YNN....LIEQEISGDLLKELSLQD..CKDLC..GsAN..........LK.LAIKFKLQLNKLL----rken.....................
A0A1X7R366_9SACH/47-121                ...........................................s-NYELWTVDEVINWCIPL.LDITE.D..H.P.L..ISN....IQLNNIDGDVINDLSFED..CKELC..N.GS..........LQ.DTIKLRLALNKLKDN--ns.......................
G0VAU1_NAUCC/37-112                    ............................................ENYEHWSVQEVVTWCSME.LSLAE.S..D.S.L..CQQ....LKINSISGDVLSELTMND..CKELC..S.ND..........LK.RAIKLKIALNKLISD--qds......................
Q6CUY2_KLULA/2-76                      ............................................SGTNEWSTEEVCKKVKAE.LGLTD.G..D.T.F..ILD...rIRENKITGSTLSEITLAD..CKELC..P.DS..........IS.-AVRLKTCINKFVDTEE.........................
Q6FX88_CANGA/16-90                     ............................................DNFDKWTTDEVVQWCGTV.LGKDE.Q..E.P.L..FTR....IRDNNIDGSVLQELTLQD..CKELT..D.ND..........LK.EAIKLKLWLNKLIDSQL.........................
A0A261C0V1_9PELO/1043-1119             ...........................................h-DYYNWKSADLAAWMKSV.LSLDD.R..D.P.L..LQK....MIDEDMDGLVLEEFLRDEsvCITTL..G.VN..........TG.RSIKIKGAIIKVVN---nra......................
J7RW15_KAZNA/42-126                    ...........................................g-DWKEWSVENVVSWCQTS.LNLPD.D..D.V.L..CRQ....LAENEITGDLLPELCLDD..CKELC..T.GDngavpavegtVQ.KAIRFKLMINKLVN---eng......................
Q751W9_ASHGO/75-129                    .....................................taptlds------------------.-----.-..-.-.-..CRR...nFRQHKITGDVLPFLTLDD..CKQLF..D.GD..........AR.LGVKFKIAINGL-----krfe.....................
S6EX59_ZYGB2/29-106                    ..........................................ee--YISWSVEDVVKWCAFS.LEIPE.D..D.A.L..VNQ....LRSNAINGELLGELTLDD..CRELC..E.GD..........LS.LAIRFKVLLNRLQ----qgvdsdv..................
C5DZ24_ZYGRC/18-92                     ...........................................e-EYTRWSVEDVVKWCIFS.LELQD.E..D.P.L..VDQ....LRKNAINGELLGELTLED..CKELC..E.DD..........LS.LAIRFKVLCNRLQ----qgvn.....................
J4TXQ0_SACK1/30-104                    ............................................EDYSQWSVDDVISWCIPT.LEVEE.S..D.V.L..CRN....LRENDIVGDLLPELSLQD..CQELC..E.DD..........LN.KAIKFKILINKLRDTKL.........................
A0A1G4JZE5_9SACH/20-96                 ..........................................ee--LLEWGVDEVLTWCEQK.LAIDE.K..ElP.Q..IRE...rFYQNAIDGPSVLELDLDD..CKQLL..N.ED..........AQ.LAVKLKLEINRLKH---qeh......................
G8JM97_ERECY/97-150                    ...................................idpyssiks------------------.-----.-..-.-.-..--N....FHENAITGDVLPFLSLED..CKRVF..N.ND..........TK.LAVKFKVSINKL-----ervt.....................
C5DK31_LACTC/14-90                     ..........................................ee--VLNWGIDEVSIWCAQK.LALDG.GrrD.K.F..QAN....LKEHGIDGQVLLDLELED..CKQLT..D.ND..........SS.LAVQLKLEVNRLRAQ--kq.......................
A0A1G4JVT6_9SACH/10-88                 .........................................pev---RSWTTDEVCAWCAEV.LRVED.A..D.A.LsaIED...aVRENNIDGQVIGDLTLDD..CKSLV..N.GD..........RR.LAVRFKIELNRLRS---ksqe.....................
#=GC SS_cons                           ............................................XXTTT--HHHHHHHHHHH.HSS-T.T..S.C.H..HHH....HHHTT--CCCHHHHHHHH..HHHCT..T.S-..........HH.HHHHHHHHHHHHHH-XS.........................
#=GC seq_cons                          .............................................shtpWos--VstWCtp..Ltlsc.p..-.s.l..hpp....l+-NsIsGslLsELoLpD..CKcLs..s.s-..........hp.hAl+hKltlNKLhs...pt.......................
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