GenomeNet

Database: Pfam
Entry: S_4TM
LinkDB: S_4TM
Original site: S_4TM 
#=GF ID   S_4TM
#=GF AC   PF18159.2
#=GF DE   SMODS-associating 4TM effector domain
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Burroughs AM;0000-0002-2229-8771
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   Laks
#=GF GA   26.90 26.90;
#=GF TC   30.20 30.20;
#=GF NC   25.60 25.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   26590262
#=GF RT   Comparative genomic analyses reveal a vast, novel network of
#=GF RT   nucleotide-centric systems in biological conflicts, immunity and
#=GF RT   signaling.
#=GF RA   Burroughs AM, Zhang D, Schaffer DE, Iyer LM, Aravind L;
#=GF RL   Nucleic Acids Res. 2015;43:10633-10654.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Predicted pore-forming effector domain found in conserved genome
#=GF CC   contexts with diverse nucleotide synthetases including the SMODS
#=GF CC   synthetases. Predicted to function as a pore-forming effector in
#=GF CC   a class of conflict systems reliant on the production of second
#=GF CC   messenger nucleotide or nucleotide derivatives. S-4TM domains
#=GF CC   are predicted to initiate cell suicide responses upon their
#=GF CC   activation [1].
#=GF SQ   111
#=GS A0A2P5IHI4_9GAMM/2-303   AC A0A2P5IHI4.1
#=GS A0A1I1G6Z4_9ACTN/6-293   AC A0A1I1G6Z4.1
#=GS A0A2T0U5L7_9SPHI/2-290   AC A0A2T0U5L7.1
#=GS I4VJP8_9GAMM/2-292       AC I4VJP8.1
#=GS A0A1I4ABB7_9FIRM/5-263   AC A0A1I4ABB7.1
#=GS A0A0H5CNU5_9PSEU/5-299   AC A0A0H5CNU5.1
#=GS A0A1M5ZAL7_9ACTN/1-250   AC A0A1M5ZAL7.1
#=GS C7RWA4_ACCPU/2-291       AC C7RWA4.1
#=GS A0A1C6SHK1_9ACTN/6-294   AC A0A1C6SHK1.1
#=GS A0A438M081_9ACTN/16-310  AC A0A438M081.1
#=GS A0A2I6S9D1_9RHOO/1-210   AC A0A2I6S9D1.1
#=GS X8FKG1_MYCUL/1-250       AC X8FKG1.1
#=GS A0A2P8AZV3_9ACTN/6-291   AC A0A2P8AZV3.1
#=GS E3E584_PAEPS/6-301       AC E3E584.1
#=GS A0A109CIT0_9BURK/2-291   AC A0A109CIT0.1
#=GS R9MPA1_9FIRM/3-286       AC R9MPA1.1
#=GS V6KRS4_STRRC/7-295       AC V6KRS4.1
#=GS A0A1V4I726_9CLOT/2-288   AC A0A1V4I726.1
#=GS A0A3N5BXC4_9BACI/1-289   AC A0A3N5BXC4.1
#=GS A0A1I2H615_9ACTN/6-303   AC A0A1I2H615.1
#=GS A0A1W1Y3F6_9SPHN/3-291   AC A0A1W1Y3F6.1
#=GS A0A402DPH8_9CELL/3-286   AC A0A402DPH8.1
#=GS R9AWE5_9GAMM/2-305       AC R9AWE5.1
#=GS K0IZU2_AMPXN/6-287       AC K0IZU2.1
#=GS A0A3T0YAE1_9MICC/12-298  AC A0A3T0YAE1.1
#=GS C7Q3J3_CATAD/14-299      AC C7Q3J3.1
#=GS A0A1G7YKC5_9RHIZ/3-292   AC A0A1G7YKC5.1
#=GS A0A3Q8V9V7_9ACTN/1-272   AC A0A3Q8V9V7.1
#=GS A0A0A6RYT6_9GAMM/2-293   AC A0A0A6RYT6.1
#=GS A0A1H9PV55_9BURK/5-294   AC A0A1H9PV55.1
#=GS A0A416R2I8_9FIRM/4-227   AC A0A416R2I8.1
#=GS A0A1C7GT93_9FIRM/4-281   AC A0A1C7GT93.1
#=GS B9XA01_PEDPL/8-298       AC B9XA01.1
#=GS A0A1L3MEB3_9MICO/14-299  AC A0A1L3MEB3.1
#=GS A0A0P0DPQ9_9MICO/1-285   AC A0A0P0DPQ9.1
#=GS A0A1Y4INP5_9FIRM/3-290   AC A0A1Y4INP5.1
#=GS A0A377YZU6_KLEPO/1-119   AC A0A377YZU6.1
#=GS A0A0X8WUI6_9CYAN/2-293   AC A0A0X8WUI6.1
#=GS A0A270B6J7_9SPHN/4-292   AC A0A270B6J7.1
#=GS A0A085FEP9_9RHIZ/1-73    AC A0A085FEP9.1
#=GS A0A328AJ74_9CAUL/3-293   AC A0A328AJ74.1
#=GS A0A1Y0GZD4_9BACT/1-255   AC A0A1Y0GZD4.1
#=GS A0A172UHK5_9MYCO/13-299  AC A0A172UHK5.1
#=GS K9Y0U0_STAC7/2-293       AC K9Y0U0.1
#=GS I4C983_DESTA/3-299       AC I4C983.1
#=GS A0A1H2Z5U5_9PSED/2-303   AC A0A1H2Z5U5.1
#=GS A0A1M5JAF6_9BACT/3-286   AC A0A1M5JAF6.1
#=GS A0A2X2PZC8_RAOPL/2-240   AC A0A2X2PZC8.1
#=GS A0A1W2HAC2_9BACT/6-296   AC A0A1W2HAC2.1
#=GS A0A1I5PZD2_9FIRM/7-262   AC A0A1I5PZD2.1
#=GS A0A0Q0G9L7_9GAMM/2-298   AC A0A0Q0G9L7.1
#=GS A0A0A1DSK4_NOCSI/2-281   AC A0A0A1DSK4.2
#=GS A0A1D2I474_9ACTN/10-292  AC A0A1D2I474.1
#=GS A0A2N0WN21_9GAMM/2-297   AC A0A2N0WN21.1
#=GS A0A416BEP1_9FIRM/1-184   AC A0A416BEP1.1
#=GS R6WMP5_9CLOT/6-287       AC R6WMP5.1
#=GS A0A1C4V2B3_MICEC/6-292   AC A0A1C4V2B3.1
#=GS A0A2N4UCV3_9BURK/2-291   AC A0A2N4UCV3.1
#=GS A0A133XEE2_9RHOO/23-312  AC A0A133XEE2.1
#=GS R5LBQ4_9SPIR/6-291       AC R5LBQ4.1
#=GS A0A0D6A0T1_9LACO/21-306  AC A0A0D6A0T1.1
#=GS A0A250VQU2_STROL/7-295   AC A0A250VQU2.1
#=GS A0A2X2Q0C7_RAOPL/1-146   AC A0A2X2Q0C7.1
#=GS A0A024FGI8_9FLAO/2-284   AC A0A024FGI8.1
#=GS F7VIC8_9PROT/16-303      AC F7VIC8.1
#=GS A0A136PLV7_9ACTN/1-284   AC A0A136PLV7.1
#=GS L7FBN2_9ACTN/6-296       AC L7FBN2.1
#=GS A0A251WAG2_9CYAN/2-293   AC A0A251WAG2.1
#=GS A0A1C6SAK4_9ACTN/16-301  AC A0A1C6SAK4.1
#=GS A0A1C5JBJ9_9ACTN/6-294   AC A0A1C5JBJ9.1
#=GS A0A1Q8C9Y2_9PSEU/5-291   AC A0A1Q8C9Y2.1
#=GS A0A1G8IK48_9BURK/2-291   AC A0A1G8IK48.1
#=GS A0A432LB44_9BACI/5-288   AC A0A432LB44.1
#=GS R7GKI1_9CLOT/2-278       AC R7GKI1.1
#=GS A0A257L2S7_9BACT/2-290   AC A0A257L2S7.1
#=GS D7E2D6_NOSA0/2-38        AC D7E2D6.1
#=GS A0A1X0DT21_9MYCO/1-256   AC A0A1X0DT21.1
#=GS A0A2A2Z5E2_9ACTN/2-260   AC A0A2A2Z5E2.1
#=GS A0A1T4PVQ6_9FUSO/1-279   AC A0A1T4PVQ6.1
#=GS A0A433SEV3_9BURK/2-291   AC A0A433SEV3.1
#=GS A0A0U2PJN9_9ALTE/3-304   AC A0A0U2PJN9.1
#=GS A0A0X3V6W0_9ACTN/1-285   AC A0A0X3V6W0.1
#=GS A0A369XUS9_9FUSO/2-286   AC A0A369XUS9.1
#=GS A0A328YS72_9FLAO/6-297   AC A0A328YS72.1
#=GS A0A372FXZ7_9ACTN/6-293   AC A0A372FXZ7.1
#=GS D0GIV8_9FUSO/3-259       AC D0GIV8.1
#=GS A0A428YTF7_9ACTN/1-277   AC A0A428YTF7.1
#=GS A0A1K1NT26_9FIRM/5-284   AC A0A1K1NT26.1
#=GS G8SGB9_ACTS5/15-306      AC G8SGB9.1
#=GS A0A2T4V0Z5_9DELT/16-299  AC A0A2T4V0Z5.1
#=GS C6D7P5_PAESJ/1-191       AC C6D7P5.1
#=GS A0A1N6JYV9_9BURK/2-290   AC A0A1N6JYV9.1
#=GS A1AY84_PARDP/4-293       AC A1AY84.1
#=GS G7M070_9CLOT/8-313       AC G7M070.1
#=GS A0A0A0BXW2_9CELL/12-297  AC A0A0A0BXW2.1
#=GS A0A1H9RI66_9BURK/16-305  AC A0A1H9RI66.1
#=GS A0A2H9U5B3_9GAMM/1-132   AC A0A2H9U5B3.1
#=GS A0A395LNZ9_9SPHN/2-292   AC A0A395LNZ9.1
#=GS A0A0M8WQN4_9ACTN/6-296   AC A0A0M8WQN4.1
#=GS U2SIW5_9FIRM/4-221       AC U2SIW5.1
#=GS A0A2X2PWT1_RAOPL/2-140   AC A0A2X2PWT1.1
#=GS A0A2N1F5Z9_9FLAO/3-289   AC A0A2N1F5Z9.1
#=GS A0A176T6B5_9FLAO/6-297   AC A0A176T6B5.1
#=GS A0A1I4J5Z4_9BACI/2-301   AC A0A1I4J5Z4.1
#=GS A0A0L0AT10_9ENTR/1-282   AC A0A0L0AT10.1
#=GS A0A132MWY8_9ACTN/16-301  AC A0A132MWY8.1
#=GS A0A0F0LVQ3_9MICO/1-285   AC A0A0F0LVQ3.1
#=GS A0A1C4RA98_9ACTN/24-215  AC A0A1C4RA98.1
#=GS A0A429B461_9ACTN/16-310  AC A0A429B461.1
#=GS A0A3P4B7V8_9BURK/2-291   AC A0A3P4B7V8.1
#=GS A0A0A6UR84_ACTUT/1-280   AC A0A0A6UR84.1
A0A2P5IHI4_9GAMM/2-303              ...........NTLYTSQSTPDNMSLLYAQAHLYNRIKIFSSVNFFISIVLPVLLSVAAA..ILKSrysv.....pqelLSAYMGLYGLIVLTVN-IALSGYISSERRKAATIQEMYDCNVLR..IKWNDLRV..GKKIS..RDN....VF.RAARFY.........qDRPAKAQARFGseGWYV.NKS..YDAPQSVMALLCHGKNFGWDRSLRDRLNVFYIWGISMSLFSLLLYGI..MMKATLNDAL..-FYVVFTLPLIRYILLQFLDNRKSRDRIEKVKDYIDKEISDIKIAGRFNNd....dLNYKLRSIQDEVFSH.RATSPPVPNFIHLRMKKDNEAVYDDYFEE-n.................................................................
A0A1I1G6Z4_9ACTN/6-293              ..........k-SLLSRQTEPEMMALLRAMSGCHARAQRLDNLRMIFSILLGVAGAVVAL..T-GV.............SSTVVTAVGALWALANAVGLGTWSRGQLGRAAVLQEMFDVRLFG..LPWNTVAA..GGEVS..AAE....VS.RLHRAY..........---RGDERYLR..DYYE.--V..PALPTPYDVLACQQQNLGWGARVRRRYAHVVLGGTAVWAVLGVVFGV..TAGLTVSQLL..LQWYVPSLGALLLGLEIYRSQRDVAAEREQALAVMQERIAATVARHGAHGs...aeLFTLARQIQDLIFRS.RQRQTRVPDWFFRRFHAADRHDFQAAMTT-l.................................................................
A0A2T0U5L7_9SPHI/2-290              ...........NRITTAQNEPIQLERLAAQRELYTSAKLYHIWQIFFMVVIPLMLSLLLL..LHEP.............LIPFAAFYGIISAILDPLLFDAVIQRRIEKAAKIQELFDCAVLR..LSPSPLKT..SNDQM..VED....VL.THYNAH..........KKIQSNIEKIK..DWYP.QAI..EVLPYPIARLICQRTNCYWDSRLRRRYSNFVSLLGIGLFIAFMLFGI..TTNKNFNDLV..-LIASALLPLVQFCLKQSKDQKETAKRLDRLVDFAKQAWDEGMSNTSSN-......LEEVSRRLQDEIYDH.RSKSALILNFMYRRFLKKDEEIMNSTAEA-l.................................................................
I4VJP8_9GAMM/2-292                  ...........NSIPNVQNDPAQLHKLAAQRQLYGTAKRILAWQLILTGPIATLSALFAI..AYPE.............ARPFVAIWGATIILVDLFWLSEWQKQKREQGAKAQESFDCDVLN..LPWNQLKA..GSKLD..PEL....IK.EQSDAY..........QAWAVRMPTLR..DWYP.IEF..GQLPLHVARIACQRTNCWWDGKQRRHYGVVVLSAIVVVLMLVLAAAL..FASVSYRDLV..VVVLIPLAPMIVTGTRQYREHTQTAERCDKLKEHANSIWAQAMSGASAGR......LKKACRELQDEICEG.RKRSPPVFDWMFRRLRNRYEGQMSFGAGE-l.................................................................
A0A1I4ABB7_9FIRM/5-263              ..........t-QITQKQNEENMLKCQFASHICFNQAEMLNYFSWFLS----IIGSLLVF..TPSE.............ETSFLIIIPGILGIMT-LVSHNLAKNNVKWGAKMRNYFDNEVFG..LEKPEYTA..EVTHS.iWEK....IN.SIENKYsrlc.qysihATDQSDTPGMK..DWYTfPK-..NYTTSEAAVFECQHQNYWWTNKEYNIRR-IIYLIAFSVLIIAIIVGI..--HYSPIKTL..ACFLGFAVNLYEDFS-----------------------------------......---------------.------------------------------esirchelmvsmktildnpdaesnlslisqlqnyiekrrellilei....................
A0A0H5CNU5_9PSEU/5-299              ..........r-SIDQRQLDGDMVRLQRAAAASHQRGQAVEAVRTTAAGLLAAAGVVVTL..AGPG.............-RQAMAIIGFAWFLVSAFPLRRAAAAIALQGALLQEMFDTSLFR..LPWRTMVA..GDPIP..EAE....VH.RLARRL..........KSGCAKDNRIA.eGWYD.P-T..GGVHHPYDVLMAQEQNLAWDARLRRRYAAVLLTAAACWSLLGAVTGI.lVSGTTLTEVL..LGFYVPSLSAYQLVCEIWAAQQRVAAERERLVRIVTSELRAARPGSLDDVeq..rrLCEVARDVQDGILRT.RVDPTRVPEWFYRRRRPNDEMDFAATTAN-h.................................................................
A0A1M5ZAL7_9ACTN/1-250              ..........m--------------------------------------VIGLGAPVISV..IWPD.............LAVVSGAIAGLWIFLGQSVLISAQSAGVNKAAAVQEQFDFYVFG..MPSSVDR-..STLPS..IEE....IA.TVAGPDp........eLRQTATDEKLL..DWYP.VD-..SSNSGILTVAISQRANASYSDRLLRSTAIVWTSLTVIWAVALIVTTV..VYDLSLATFL..VGIVLPVLPSFLDVVRYVVGIRRAARDRGDLTRSIEIRMRGSTDSI----......EGNDLLVWQESLYEL.RRSTPLVPDLIYKMKWAVNEGAMKTAASQL..................................................................
C7RWA4_ACCPU/2-291                  ...........NEIDKQQVQPRMLNLLRARTLIYRRAKNYQAVGLVISLGLPLVGLAAAA..LFSA.............SKPFIALFALTFSYLEVLFFDPWLRTQLKTAAKLQEDFDCTLLG..MDWNVFLA..GSRVD..PEQ....VF.EDACRT..........-LSAKDEKRLL..DWYP.LTV..NALPLHLARLVCQRTNIWYDSALRKRYRMVLLFGAVAIMFFVGMGSL..WIDTTITSFV..LSTLAPMTPMMIWALRERNRHAATCELLDRLNEDVKKLFDKSRAGATEQE......ISMRSRELQDAIYNH.RVSSPLIFDWIYNRLRSQMEERMNAGAQEL..................................................................
A0A1C6SHK1_9ACTN/6-294              ..........d-SLLRRQNEPEMMSLLHAMSVCHSRAQRLDNLRLAISVAIGAAGAVVAL..TG-V.............SATAVTAVGALWAVANAIGLGTWSRGQVRRAAVLQEMFDVRLFG..LPWNAVAA..GDQLA..PEE....VS.RLDRAY..........---RGGEKYLR..DYYE.--V..PPLPRPYDVLACQQQNLGWGSRLRRRYSYAVLAGVALWMGVGVVFAV..TAGLTVSQLL..VQWFVPSLGALLLGMEIYRGQRDVAAERERAQTILQRRVTAAVRHGDDPSta..pdLLTLARQTQDLIFHS.RQGQARVPDWFFRRFHAADRVDFQAAMAS-l.................................................................
A0A438M081_9ACTN/16-310             ..........r-AIHERQLDDAMLLLQRAAAASHQRGQLLEAVRVTAAVALAAAGVLITL..IGHG.............-RTAVSIVGFFWFVVSAFLLKGLAGNTARQGALLQEMFDIALFH..LPWRATVA..GDPIP..QPD....VR.RLARKL.........pRGGAKDKRITD..GWYD.P-T..NDVHHPYDVFIAQEQNLAWDARLRRRYSHLIAATAILWTTIGLVVGL.aVADATLLDTL..LSFFVPSLAAYQISYEIWSGQRKVADERDRLTKVVNTELHNGRPGPVPDDew..hrLRNVARDVQDGVLRT.RLDTTRVPEWFYKRFRDDDERDFGDTAE--gh................................................................
A0A2I6S9D1_9RHOO/1-210              ..........m-------------------------------------------------..----.............----------------------------KEAATIQELFDCEVLS..LPWRQSVA..GRKPE..YED....IQ.PYAATP..........-LRPERESHLK..SWYE.PCV..ASVPLVYGRLICQRANICYDIRLRKVYKKLLLWGAVGLTAFAFVIGV..ATNLAFRDMV..LSVFVPVAPMLGWVIREHRSQIETIISLQQLKDAFDELWEKALRGDGDLD......IESGARDLQDRIFQH.RTNNPLIFDWIYDLLRKENEDGTRAAAEQL..................................................................
X8FKG1_MYCUL/1-250                  ..........m---------------------------------------MGIVAPPLAV..FFPK.............AAVVVGAVAGVWILLSRTIFKAFGGKLAAQGAAVQEDFDRFVFD..MPPLATRV..-PRPT..PED....VA.ELAGSDt........eVLDRAKQGGLL..GWYP.LD-..RGAAGTVCVAIAQRANAAYSERLQRLNARYWLTVLVVWTVVIVMTSM..IIGTSLTTFL..LGVAAPLLPACLDIGEQLRSSTQACADRRSMADDIEHAVRGTTDNPLND-......--EDLLVWQERLYSL.RRSAPLVPDLIYARTRRKNEEAMNSAAAEL..................................................................
A0A2P8AZV3_9ACTN/6-291              ..........e-SLLTRQNRPDMMALLHAMSVCHRRAQRLDNLRMLLSVTVGVAGAAVAV.tGLPG.............--TAVTAVGALWAVVNAVGLGSWSQGQIRRAAVLQEMFDVELYR..LPWNEVAA..GEPVS..AHE....VS.RLERSF..........---RGGEEYLR..GYYE.--V..PPLPHPYDVLACQHQNLAWGSRLRRRYAYTVLAGVAAWAVAGVLFAV..TTGLTVAELL..LQWFVPALGALLLGLEIYRGQRDVAADRERALAILQRRIDAAAGDPAGTG.....eLLILARRIQDLILLG.RQRQARVPDWFFRRFHAADRVDFQAAMDS-l.................................................................
E3E584_PAEPS/6-301                  ...........NDIFLRQNEDGNIDLLAAQRQMYSEAKRASNYQFAICVVVPILVPFLKA.vALSNm...........iYLGFITLLPLVIIVVNQYFFEKIIKNKKEKAAKFQELFDTNVFK..LSWNNRLS..GSKEF.aTKD....LS.NTAQKY..........KKKHVSLSNLK..NWYP.KEY..STVDISAGRVMCQKVNASWDGEIRASFQSFLIKLLFVCIFLIIAISM..LLNKTFAETL..ISIIAPLFPITFYIFKRYSENKETIVRLDKLTDKADRLWEDVLSGSVEQN.....dLQIQSRKLQDEIYKH.RSSALLIWDWFYLRNRSKQENNMNDTAN--li................................................................
A0A109CIT0_9BURK/2-291              ...........NEIDRKQVETRMLHLLRARTLIYRRAKNVQAVGLIISLVFPIVGLIVSA..LLLP.............SKPFIAFAALMFSFLEVLLLDRWHRTQLKNAAKLQEDFDCTVLR..MDWNTFLV..GNRID..PED....VF.ADACRK..........-LSDKDEQRLI..NWYP.LAV..KELPLHSARLVCQRTNLWYDSALRKRYRRVLLTGCVVLIAGAGVVSL..AIDHTMTTFV..LSTLAPMTPVMIWALRECNRQAATIELLDRLNDEVKKLLDRARSGATEQE......ISMRSRELQDAIFNH.RASSPLIFDWVYNLLRRRMEEQMNAGADQL..................................................................
R9MPA1_9FIRM/3-286                  ...........NGIRLRQNEEHSIEMLAAQRQLYSNAKRYDWLSTALSVWIPFGMAIILV..FIPEd...........sLAGIVSYIVSITSAVISFIVDGIINNKKELAAAIQQKFDTYIYN..MPWDTRIF..GKNRN.lNNE....IA.VYSSKI..........LSDEEEKKSLY..DWYT.PLV..DEKELKEGILSCQRENVWWDVGLRKRFKMGSIMAIIILCIAVFIMGI..CKNESTVKLLwrFAFVAPMLEWLFSTIKQLNKDINELQELDEIINDDESK------------......SMEDLQDIQKLIFIH.RKDCFAIPNFFYKHFKDNDEDKAHRAASM-h.................................................................
V6KRS4_STRRC/7-295                  ..........a-PIVRRQNDEDLLTVLRAGESAHARARRLASARVVVSASLAA-GAVLAV..VVPA.............LQTALTTAGFLWALVYAVGAGSWTESEFRTAALLQETFDTRLYD..IPWNETLA..GNAPS..ADE....IS.RLARRY..........---KGPEERLR..DYYE.I--..RELPRPLDLLSCILQNLAWGARIRRRYAAAVQAGVIGWIVTGVAVGV..ATRMTLASLL..TTWFIPSLGLLLLGADIVRAQRETAAAREHARQVILREMREHAHSGLPPGrv..pdLLVLARQAQDVLLRT.RLAQARVPNWFFRRFLDSDRADFAAAMDE-v.................................................................
A0A1V4I726_9CLOT/2-288              ..........h-RIYKEQNSERILRLQFSQRKHYELAEFYNDLSWVLAIILVI-LSIIGT..KFD-.............LLENVRLLINAILAIGVFMVNKIAISNVKIGAATKEYIDSELFH..LDRKDKYC.dYSMLE.iKES....AL.KMKEKYekey.niqisNTGKDKPAGLK..DWYT.YK-..TDGKDVHVILKCQEENIWWNGVLNKKFLWGIGLFSLVILSLIIEIIM..VNKISLVAII..-NIILLCVSLFCKTIEDLVQAIKYYTYYIKAKSKIEAFETNMNL------......RMKDLMLLQNDINKM.RSIKFLVPNFIHKIYSKK------------lhlmlee...........................................................
A0A3N5BXC4_9BACI/1-289              .........ml----DRQNEEKNILLLKAMRHTYNRAKKVYGIRMTIGVFIPISS-IIFS..LLNQygi.......tgdFSSLFSILGLVWLPVF-YFLNQLENNEIGNGAKIQEEFDTNVFS..LPWNKALV..RTRIS..PED....IQ.EKAIFY..........---KGNISTLR..DWYV.-GL..DSKHYLVNVLLAQRSNLMWAVSLKKRFSKLILIVSILYLIITVAYAC..FIDMSMQSYL..MIIFLPSISVLLYGVSTWWELRKQSNIICELGEDIRIDCEKFVSNEIDL-......DITYCRQYQDAIYVYnRTNSVLIPEWLYWMRRKKDDEKMLE-----vnrrl.............................................................
A0A1I2H615_9ACTN/6-303              .........sv--VRQRQLDATLCHHLRAMSVSHARVQRLAALRIGVSVALAGTGLLAVL..-AGSlnat....aftrsLSITVTVAGALWALLYSLGLASWAHRELLRAALLQETFEVRLFH..LGWNHVLA..GDEVP..AED....VH.KLSSRF..........---RGSEDSLR..VSYA.--M..PSLPSPFDVLARQQQNLAWGGRVRRRYARAVLAGLLAWTAFGLLSAL..LRGSTMVDFL..VQWCVPSLGLLMLGWDTFREQRGIYADRRRVARWSRARCLQAAASSQDPAtr..qeLWLMARQVQDQLFLT.RRRAPRVPSWFFRRYYLQDSSDFTAGLA--am................................................................
A0A1W1Y3F6_9SPHN/3-291              ...........NQITTHQNEPRFLKFLRARSETYREASHWQIAQFVLTVITPLVGAVVAI..MTPD.............ARPYVAAAALVIAMLDSSLIDRIQKQKLKTAARIAEQFDCELLE..MAWNPYAA..GKKVE..PEV....IE.GAALRW..........---PNGEAKLK..GWYP.SAV..EQVPIHLARIICQRTNLWYDGTLREKYSSILLWSAIVIAILLFSVGF..AAQLSLIDFV..AVVIAPVTPVFGWTLREFFRQRDAVEALKFARAEAEALWAAALNGGCEPS.....eCARRSREFQNTIFAR.RANNPLIFPKIYDRLRSSLEIQMNRGAEA-y.................................................................
A0A402DPH8_9CELL/3-286              ..........v-SIAVAQNDPHAQRLLAAQARMYSQAKTMQHARFLVVCVLAAGTVTAAL..LASD.............VRSVIGLVGGVITFVWSQLGGTREKRVVKDAAAVQEQFDTYVFE..LPWNDLGP..VDRVD..PTR....IA.IAAAKY..........-----RGNRTV..DWYP.A-T..GAVARPLDVLICQRSNLGWGAVVHRMYAALLIATLILLVGAGIGVAL..AAGLSAAEWL..AAVAVPLLAPAREILDLVRANRDSEDTKRKAESKIAALWRGAITRQAAV-......TVQDCRVVQDRLVAI.RLSNAHVPDWLDQWWRSRNELAMRDTADS-l.................................................................
R9AWE5_9GAMM/2-305                  ..........s-NIAQRQNEPENIKILQAQRQMYSDVKFRMILIFGVGVILPIIVSFLTF..ALNNdffakl.lafekkDIGYFSACIGIFSAIVVEVISNFLKKMKEDAAKIQEVFDTNVFD..LPWDSINI..GKKPD..HSL....IF.KKSKEF..........NKRHPTYTGFD..DWYT.LKA..ATFKYPEAIAFCQQQNLNWDSSLRKDIVTASKWILVVIILIMLVLGI..INDFTLRNLL..TNVVLLVLPICLFFYKIITENNETIQEMDRLREINENLIDSTISNSLNNT.....nFISKCRQLQTAIYSH.RKSARPIPNWLHKRRKKYQEEESADRMQQ-y.................................................................
K0IZU2_AMPXN/6-287                  ..........s-SIHIRQNLPESIEQLRAQRSCYNIVEKMYIWRMIISIFLPIFSVSMYF..LFDN.............DLANFVLILTGIGLLVCLMLEYYEKTYSVKGAKIQEMFDTQVFQ..INWNTALL..GDKVS..LED....IH.LLALKD..........---KTPESELA..NWYT.G-L..VSDEERINILTAQRMNLSWTHRQKHKFKWVLILTFSIILISSIVIGC..LIKLSLITFL..ITFIFPSLSLYTYLLKNFIEIHIQGKELQRVILLIEQYIENGSP------......KKSDLRSIQDAVYIYgRIPNHIVPNFIYKLLRPKYESSFEKTNKK-l.................................................................
A0A3T0YAE1_9MICC/12-298             ..........a-TIAHRQNDEQALQLLVAQRRFYNRAKRWQSLRWIGILIIGLGGPFFSL..LAPA.............VAVSVAAVTGVWLFAGRTVLALLENRTMLKAACVQEELDQYLFD..MP-DTIDR..SGRPT..PED....IA.LIAADKk........pLRDVAKKEKLV..DWYT.VD-..ADSPGTTTIAIAQRSNAAYTDRLIRTTVTVWAAAAILWLAGLITWAS..ISEVTLATFL..LGALFPVLPAFLDVSEYVMNTWKAARDRADLAATIGRRFSRRDQSI----......EPQDLLVWQERLFDL.RRTTPQVPNWLYKITRARNERAMRQTASH-l.................................................................
C7Q3J3_CATAD/14-299                 ..........a-DIRTRQDEIEHLRRLRAYSHMYNSAQMWRRLRAAGTLALALIAPVVAV..FVPS.............STDTLAAVGAGWLVIGRTVLTRLEQHARGDAVRAHELYDTKLFH..LPWNQSLA..GSPPS..PDD....IV.RAAERV..........----PDHERYH..DWYS.IDL..TGVAWPGDVLLCQRQSMVWSRSDHRAYGNAVLAAGLGWFTAGLVLAV..VKDLSLSDYL..IKIFLPCAPAFLDTSELAHEHRQHSIAREQTENDIRELWNTYRLAPDNL-......PVGETRRIQDSAFQL.RRTGPRVPTFYYRLRRSSSQHATVTATAE-l.................................................................
A0A1G7YKC5_9RHIZ/3-292              ...........NQIPVRQDEEAQLKLLRARTHTYTVATRLMVLQLCLTVLVPVVGAIWGA..ADPQ.............VRPYFTLLALMVLLLDPLWIDQQYKATLKRAAKIAEQFDCTVLE..IGWNPFVV..GDRVE..AED....IH.RAATKY..........-TSGHDDSQLT..GWYP.KAA..GGVPLHLARFICQRTNLRYDSELRRHYASILAGLAVAVAAIVVVLGI..VQQLTLQEWV..L-NIALLSPLLSWSIREFYRQRDTADQQQDLMKFAKTLWERCLEEDGIEN.....eATVKAREFQDAIYAR.RVSSPLVIPLVYKFLRPGLEDEMNEAAS--df................................................................
A0A3Q8V9V7_9ACTN/1-272              .......msar----------------AAARAAYSAVGRIRFLRTTGTVGLAVAAPLVSV..LWPS.............TTGITASVAAVWLVAGRTLMKNWERSWQEKGRKFQEYYDSRLFR..IDWNTALA..GR-I-..-DA....VR.EEMAAC..........-RPRRDLPRDR..DWYE.S-V..PAIPWPYDVLACQMQNALWGRRNHRAYANLLWGLFAATCVAVALVGA..LERLELEDLL..LKLFLPVAPALVDLSELPREHRGAEQAKEKTGDTIADLRDQCEAGR--PV......TAEDCREIQDAIYHL.RGINPAVPSWFHRRLRRKVTAANEAAMQT-l.................................................................
A0A0A6RYT6_9GAMM/2-293              ...........NTIIQDQLTPKQLDRLAAQRQIYSDVKTIQAVYMILSVPCVIVWSLLIV..FIPE.............LTSYAALWGITVTLLGIVIFTPWQNSLKQQAAKIQELFDCDVLQ..LKCSEMKV..SRKPD..TET....IV.EASSKF..........RRKEPEYVSLK..NWYP.VSV..GKLPIALARLVCQRTNCWWDAKLRRRYAMAIIIVVIILTIFVFLLSL..IGGFSLDKFI..LAVLTPLMPIILLGTQHYIENTQSATLLDDLKESTEKLWEQAISGKITLK.....iLETESRELQDEIYHH.RCKSPLIFDWIYRIFRNPHEEQMNKGADS-l.................................................................
A0A1H9PV55_9BURK/5-294              ..........h-QINVEQNKPERLVLLRAQRLFYARAKQYQAWFTLLALVLPLMGVIFGA..SHPE.............IRPYLGFGSIVVLLLEVGVVARLQKEDCKRGAKVQEQFDTEVLK..LDWNQLVA..GRRVD..AEE....VR.AITTTE..........-MSDSERKRLQ..NWYE.VDV..SRLPVQLGRLICQRTNLAYDMRIRRKYVAILIGAAGVISVTLVFVGI..YQGLNLNDLI..LTLCLPVLPLVAYVLREHRKQNDTIETLTTLKSEVEKVWDKALSGASSTE......LTTASRALQDAIYRH.RASNPLVFDWLYNKLRNNEEDQTRHAVER-l.................................................................
A0A416R2I8_9FIRM/4-227              ingipciadif-------------------------------------------------..----.............----------------AFLFSIITSQKVNLASTLRKYFDSYVLD..IQLNQFSEteLRKIReqTEK....IY.LK---Spina.aiqmsNTGSDSPPGVR..NWYTfS--..EFYDGLDAQFECQRQNTWWNSK------MVMIRTIATVVVLFVVGGI..FIALLLSNNI..LNILLCSAGILIKICERIIENWRYLCISRQIDGSQQTI--EVHP------......TKEGIEKLQNLIDER.RSINVLELGWFHNKLANKF-----------sklyekl...........................................................
A0A1C7GT93_9FIRM/4-281              ..........k-SIMERQNEDKMLRYQFSARRHFNLAEKWNYACW---ALLAV--SWASM..FLPDt..........epL-NTIRNVGIVVIDLIATFCAVRTEKNAQLASALRAHFDAYVFG..LE-QLSDF..GNKWE..LDE....IT.LKDKERfpqefdiqtkHNGSDVPPGVK..DWYE.ID-..ESKEGIAAILECHGLNTRWETRLEKYRIIAFIVMLVLLISIMVAMLC..ISAVGPLTVL..LSSVGLIIHI----C-----------------------------------......---------------.------------------------------krinislhryrvmiqintlrdavevsntldsvvllqknineyrafpvlgidlvhklraktwterdr
B9XA01_PEDPL/8-298                  ..........c-DIPEKQNIERSLKHIAAWSHLYGHAKVVAGWQLILSVPCALVMSLVAL..RWPE.............AKTVTTPFSLLFGWIDVLWLDRIQSDRKKVAAKMQEQFDCELFG..LGWNEIRC..SSPPE..TEE....LN.EAADAF..........-RRKDPKANHR..DWYP.VEV..GRLPSSLARLICQRAAVWWDMSQRRKYARWLVAAVATLVVGVVAISF..TADQRVRDMV..LSVYVPIAPAVVWAVRECIRQRDAVSALEKLKGQIEKVFARAISGKQNFG.....eIDRLARHIQDMICDG.RSRNPLFFNFIYRRLRPDHELRMNEKAEEM..................................................................
A0A1L3MEB3_9MICO/14-299             .......amkv-----RQNETQALRLLIAQRRWYRRAKRWLAVRWIGMIIIGLTAPVISV..IWPS.............LAVAAGAVAGLWLFLGRTVLVLMQASITAKAAAVQEQLDFHIFG..MP-RTADR..STLPS..LEE....IS.AIAGPDd........eVEAIAAKEELL..DWYP.IN-..DADAGPVSVAIAQRANASYTDSLLRTTAIVWTVATAAWVIVLVIVSL..LAGLSLSTFL..LGIALPVLPAFLDVVQYVVGVWRSARDRADLARTIAGHLDGSAGP----V......QAEDLVVWQDRMYEL.RRAAPEVPDLLYKLKRKVNERAMTSAARQL..................................................................
A0A0P0DPQ9_9MICO/1-285              ..........m---RERQNHMDALRLLIAQRRIYSVAKRWQSARWVGVMIIGIAAPVLAI..IVPQ.............AAVVVGAVAGAWLFFGRTAFAWGETLKMGRAAAVQEDFDRYVFA..MPVTIART..-TAPT..RED....IA.AIAGDRa........qTLAIARREKLL..DWYP.IS-..PGASGATSVAVSQRANAAYSDRLLRATVAVWASASLGWALLMTIVSM..AAGLSLGTFL..VGVLLPVLPACLDAFEYIRSTFLAARDRRDLAATIESRLLTGAAP----V......DGQELLVWQERIYEL.RQTTPQIPNWLYRLLRPRNEAAMYAAADD-l.................................................................
A0A1Y4INP5_9FIRM/3-290              ...........NSIYAQQNEKFLLECQLAQRDEYSQAKRANQLKSIITLAFAIFSVVVSI.lDCDT.............LSALSSLFAVSLVVFN-KYSDGYISSHKKHAASIQQYIDVTLFSsiIGGATSEW..GELPN..KTD....LA.KTTSKF..........--SGVDTSDMK..NWYS.D-Y..SSLSGEAQVFHCQRENVRWDYGLHKSYICLQLGILLVAVVAMVASMF..IVNPNFIKLIciLSWLTPLVEYIYSVCKEVFESNSLLKKIDAFCDKIENKLSGDNNVS----......IKQELIDLQYKIRER.REVGFLIPDWFYKMRKRKHQKQEDSIAE--ti................................................................
A0A377YZU6_KLEPO/1-119              ..........m-------------------------------------------------..----.............--------------------------------------------..--------..-----..---....--.------..........-----------..----.---..-----------------------------------LLSFLVLLAYGL..WSKSSLEDFL..-FYIVFMLPFFRHVIMLYVENNKSINRIMRVKDFIEKKIQNIKISGIINDd....iLSHDLRSIQDEVYTL.RSTSNPVPNCLHRFMRKNNEAIYDDYFE--dn................................................................
A0A0X8WUI6_9CYAN/2-293              ...........NNIPQAQNTQRSLDLLAAQRQLYSDAKGLQMVSVIMSVPVVIAWSILVA..LFPP.............LAVYAALWGIVATLLELLFFSRLQKSTQEKAAKIQQIFDCEVLQ..FNWASLNC..GVRIE..PET....IV.DASNRY..........KRKKRNLTKLQ..NWYP.ISV..GQLPIHQARIICQRSNVWWDAQLRRRYSKWIVFVLFVLTVIVLLIGL..IGGLTLEKFL..LAVLAPLTPAFVFGLRQYTEHNESAVRLDRLRENAEALVQEIINGRYTPQ.....dLERESYSLQTQIFDN.RRRSPLILDWLYSRLRNEDEEKMNKGAEA-l.................................................................
A0A270B6J7_9SPHN/4-292              ...........NTIPERQNSREMMRLLRARSEIYRRAVIMQKAQLCCTVVVPVICAIVGL..LAPA.............TRPAVAALSLALVLLDIGLIDRSLKKGLKTAALVCEAFDCALLE..MPWNRFAT..GKPVD..PEV....VA.NADRRW..........---PKGEAKLE..NWYP.VIV..GKAPIHVARVVCQRTNLWYDAKLREDYGRYLFLGAFLVVAALVVAGL..AVKLDFADFV..ATILAPATPIVGWAIREAFRQRDAAEAQRTTKSEADALWELIVLGDCPTD.....eCTRRSREFQNSIFQR.RVGNPLIFPMIYDRLRDDMEQDMNLAAE--vl................................................................
A0A085FEP9_9RHIZ/1-73               .........mk-------------------------------------------------..----.............--------------------------------------------..--------..-----..DAT....VQ.EYSSNY..........KDRVGSDDRLV..DWYP.VTA..SLVPEHQARLICQLTNAQYDGRLRAVYRTVVGLVALV----------..----------..--------------------------------------------------......---------------.------------------------------alpcf.............................................................
A0A328AJ74_9CAUL/3-293              ...........NTIPQTQNSERALKFMRARQATYFQASVNQWLQLVVTVLAPVIGAMIGL..NNPA.............TRPYVALASVAASLLDAAVLDRAQRKLLATAAKMAEMFDVEVLQ..LPWNAFVV..GPRLD..AET....IH.GAAERY..........-KGEAKMAKIR..NWYP.VVV..GQAPLPLARIVCQRTNLWYDASLRRTYGGVIVIFAVAVTAGLVGAAI..YLDLKFLDLV..TTAIVPASPVLIWAIRERNRHKDTADAQERVKGESEALWDRAKAGGCSDD.....dCAERSREFQNSIYAR.RVSSPLILPFMYPLLRNRMEAQMNVGAEA-m.................................................................
A0A1Y0GZD4_9BACT/1-255              ........mry----------------------------------LGVFVVAVSAPVLTA..YDEH.............LAVTLATVASVWYVFNIALFKYLERRGAARGAIIQEEFDMKIFC..MPMIAAR-..EPRIL..PED....MV.ALKMPS..........RRAMYSIEKLR..DWYP.IE-..TNSPGRVAIAIAQRANAAYTRRLLLWYASLWLVVLIVWAFVAVWIGL..FRDFSLATFL..LAVVIPILPPLVDAWEEFTVVRLASREREALANEIHDAIAVDAVNEI---......LPEQLLAWQSQLFSL.RRDAPLVPDWLYKLLRNRNEREMLAAAND-m.................................................................
A0A172UHK5_9MYCO/13-299             ..........p-TILARQNDVDSLRLLIAQRKLYSRAKRWLALRWTGMLFIGVGAPVLAL..FWGS.............SALYVGAAASLWLFLGRTLLVLIQNSLTTKAATVQEQFDIFVFD..MPDNKERS..-SMPS..LED....IA.KIVGPSd........kIVETAKREKLL..DWYP.LD-..ATDSGAVSVAVAQRANASYADSLLRSTAIVWGVATALWVVIVSVVSL..LSDVSATTFL..LGVVIPLLPALLDVIQYDLGVWKSAGERRDLAKIIESHLSRVAGAV----......DGQNLLVWQERLFDL.RRSAPEVPDMLYKIRRKINERAMHAAARQL..................................................................
K9Y0U0_STAC7/2-293                  ...........NSITQEQLEHKQLERLAAQRQIYSDAKKIQAINMILSVPAVIVWSILVV..KFPD.............LKIWSAFWGITVTFLGFIVFNPFQKELQEKAAKIQQLFDCDVLQ..LSWNELNS..GKRPE..PEL....IC.QKSRNY..........RRNHSDYSKLK..DWYP.IGV..SQLPIHLGRLVCQRTNCWWDAQLRRRYAYYIQLIIIGLSIFVFLIGF..INGLTLEKFF..LAVFFPLTPVLFFGINQYRDNIEAASRLDRLKDEAESYWRQAINQKLVPQ.....eLTQLSYKLQNSIYDN.RRRNPLIFDWIYNRIRDENEEQMNQGAEA-l.................................................................
I4C983_DESTA/3-299                  ...........NDIPEKQSSDRLLEYLAASSYLYGRAKVRLGCQILFTVLIPILFSIITV..LVGDsqd.......wkhLKVWAVAYGVALSILDVLFLDSEQKRLKLEAAKIQEIFDCELFD..MEWRTFKI..GSKPS..AES....IV.AAAKAY..........KKTAKNEID-K..TWYA.PEV..GDLPLYQGIVACQRSNVMWDANLRRRYNKWIRLILTLAIILTIVIGI..GKQLSVSDLV..LSVFAPISPAILWAIREYRRQVDTCDTLDKLIKHADSLWTKAKDPASSPE.....kITTEARFLQDEIYDH.RRSCPLIFDRIHDWLKDEQEEQMRRGVQEL..................................................................
A0A1H2Z5U5_9PSED/2-303              ...........NTINEDQNSSNSIDRIAAFRQAYKNAKFLGRIQI-ALVFIAFVITLASV..VINSpimpallntpqkdISPTIVVVTLFFTLFEIVFLKVKTSEQIELGAKIQELFDTEIFQ..LSWNSASA..GKKPA..IEK....IN.NLARKH..........FKKNPDTQALQ..NWYS.V-R..PSTPHPLGVLVCQYSCLSWDIELREKIRQSVILISFALTATIALTAV..LLNPDTQSTL..LNIVSIFMPVFTYAHTIYELNNKTIKHTQEIKDLLSDTMDGITPDTDDNW......IMQMCREIQNSIYTY.RASAWPIPEWFYWILRDELEDTMSYSAT--di................................................................
A0A1M5JAF6_9BACT/3-286              ...........NKIQQNLALPYSFDLFKAYSVAYDRAKQLQQIRFIISYVLSIILPLISI..VNAD.............YRPYFSIIGGIWAMIA-FFITIKEKDKIKEAAKIQDEFDTRVFD..LMPNETLV..GSRFS..EWR....IK.ELSAQY..........----KGNEDIK..TWYG.-NL..SHIPYPLNILTSQRSNIIWDWRLRKSYFTALLIALIALFLTGIIVSL..VFKLTLAQYI..ISVFLPGASAFILGIKELLEHYDNYTSKQKLESKLNGIIEKFKKGNNEI-......TDVLLRQFQDVIFLS.RKCTALVPTWYYNWKKDSYNERMQT-----vlnav.............................................................
A0A2X2PZC8_RAOPL/2-240              ...........NAIYTNQSTRENLDLLYAQARVYDRVKNWNRLNFLFSIIVPLLLSLVTV..YNRSrgfv.....dselLSSLLGLYGLLVLTFN-IAISGHISALRRKAASIQEMYDCRVLG..IRRNELKV..-EEIP..RDD....II.RAAAYF.........rDSPEKARKRFGeeGWYV.NKV..YDAPQAVMALLCHGKNLGWDKSLREVLHVFYLSAFIVSPVAMLVYGI..AMKSGLNEIL..-FYVVFTLPVIRYFLLQFLDNRSSMKRSEKLKK-----------------......---------------.------------------------------ir................................................................
A0A1W2HAC2_9BACT/6-296              ..........k-HIIQEQDSEPSIKYLAAQKQLYINGKTTFAFQVLIAVPIPILISIVTP..LLGKe..........eqRIVWIFVLYSIIATFLEFFCEDRAMKLKKLAASIQEKFDTSVLL..IDWNKTLI..SSKPD..DGI....IL.RFYNKY..........-IKKNKLDKLY..GWYS.NEV..LPVNTNIATLLCQRTNCSYDFTLRQRYTNTILLLAAATFLILLIIAG..QNGLTVPNFI..STVLFPSLPVFVLAYKQISTNKEAIENLKELKDLIEGRLETVRINDQV--......EPHLIRQIQDKIYLK.RINSPLLPEWAYNFLKQNLEDEMHFSVKE-k.................................................................
A0A1I5PZD2_9FIRM/7-262              ..........t-EIKKRQNEEENIMMQCASGYYFNIGERTNYICWVFCFLSAA----ISF..KGD-.............--QIFGVIAMLALDILTIVAGYIMTWSVKIAADLRELFDARVLF..NNNEAFDS..-LKRQylKEKalriIS.VHKDHYek.....iskTNGESNPPGKM..DWYTfN--..KDFSPIYSQLECQRQNKWWNKKMVKIRKIILVIILVTLVGTGIIVFS..KVTLSAIGLI..--------------------------------------------------......---------------.------------------------------nafgivmfrvhermrshfkyhdtsvsidtlyesasknisiekienlqkyinerrhlpv........
A0A0Q0G9L7_9GAMM/2-298              ..........t-CIVSNQKQAAAIEAGTAFRYAYNRAKFWKALIWGAALALAFVQTVASV.yIFSGnk........apfDPAYLTIGPLLTFIFIGTFGKYLVNKWQSRGCMIQRLHDYQTMD..I--GDKPS..QLELP..KSL....VM.ELSTKR.........lEQAPGDHEQLE..TWWS.SAL..KDVPYPVGKVIATYSTFAWESELRKRYQGLLVFLLVTCIAIPILVSL..TLNYTILQSL..AFVIGPFTPIIAVILDEWILNRQSLKIAEQLTQGCYSSWDNIIAGKLNND......EMHSATEQHMRYWQNfRQSATPIFEWLYKVSRKKMENNMLVDTAQ-l.................................................................
A0A0A1DSK4_NOCSI/2-281              ..........p-EIRAAQNATENLRLQAAARRLYSRTKLLDGLGLTFSLALALAAPVIAS..MSDR.............AGLWVAALAGVWLFASRLVLAPVARRVQRAAAGVQDSFDAAVLG..TPCGRSLA..-TPAS..GEE....IH.AATREV..........-----DLGRFR..NWYP.AE-..STSPWPLSVALCQRANAVWARRQHRLYGRLLTGATVAVTALGITVAI..TNAQSLQTYL..AVILLPSLPLLLDASELAGAHRAAARKRGAIEAALDEFCRAPDPAT----......ASDTVSAAQRDLLEL.RSRGPLVPDWLYRLVAPRYDDDMRFAARS-a.................................................................
A0A1D2I474_9ACTN/10-292             ..........r-PIAQHQNEPDLVQARAAARLAYSRAGRIRAVQTFGAIGLALLAPLLLL..LRPD.............ASDILAAVAVIWLLAARTALDTWHRRTRLQAVHHQELFDTTLFG..LPWNTSLA..GPRRL.vRET....VA.ARTRPL..........------IPKDH..DWYE.-NV..PDVPWPLDALACQTQNLMWTRRNHRGYAHLLWTALTLTALTAALLAT..AENLTLEQSI..IQLAVPLTPALLDLAELPRLHLEAARAQEQLEEAIDDLLAQRTAGR--PV......TTEDCREIQDGIFER.RAHQPPVPTFVHTRHRAATSAAATARMRD-l.................................................................
A0A2N0WN21_9GAMM/2-297              ..........n-NFNTNQNSDVAIDKLAAQNQLYGDAKNRLGLYLVLSIPVMILLNIIVKplLINDtfrl....gwnfdLTDSIAFYALLLTMFELVYLKPQISKLKQKAAKIQEDFDCTVYE..LEWNDILC..DSKPC..ESE....IK.NSSDKY..........TKKGKSRAVFA..NWYT.PDV..EQIDQVKAILVCQKENLGWDVSQRTKFICFISSISIVVFLLSLIVAF..FLDFTLQSFI..LSAIIPSLPAISFSITNYFENKEAIASKEKLKEATEKV-ENIRN----P-......TIKYARNIQNLIYLN.RVNNSLIFDWFYNYLRDSNQSGISYASKQ-l.................................................................
A0A416BEP1_9FIRM/1-184              ...........-------------------------------------------------..----.............--------------------------------------------..MPWDKRIF..GRDKN.vDHE....IV.THSKKI..........LSNLQEKKQLK..DWYT.PVV..DKKNTIDGILACQRENLGWDVGLRKRFKFASIILFIILVAVILAMGL..WKNERIIDLL..-WRVVFIAPMLKWLLDTIKKLNKDISTLQELDSDINNN--------E-TK......TMEDLQDIQKVIFQH.RKGCYAIPECIYNIFKDNDEDRAYREA---rm................................................................
R6WMP5_9CLOT/6-287                  ...........HKIFKRQNESAMQQLIVAQHYTYTNAKHWCFILFCILVVFPIGINIALF.fDLPD.............FATGILALSSLVLLILGEIIRDYVQGQKQRAAMLQQKFDTYVFN..I-VNQYGI..----D..ENI....IA.EQLEKY..........--KNKDWNRKK..DWYQ.-NY..ENMQDEKAVFYCQKENIDWTNAIGNKYCGFLLISLTVILLSFIVNFI..IHNSSFIRVI..-SIILAMVPLVSYGISSYKKIKHDNYELARINGFINEIDNDLNTMNEFD-......LKNRINVLQVMIYGF.RQTKYLIPDWFENIYHKRRQAIETRKARNH..................................................................
A0A1C4V2B3_MICEC/6-292              ..........e-SLLSRQNQPRMMALLRAMSVCHSRAQRLDNLRMAVSAALGVAGAVVAV.tAAPG.............--TVVTVAGALWAVANALGLGAWSRGQLRQAAVLQEMFDVDLFG..LPWNPVAA..GDRID..AHE....VS.RLERAF..........---RRDEQYLR..DYYE.I--..PPLPAPYDVLACQQQNLGWGSRIRLRYAHTVLGGVVLWSVLGVVFGV..TSGMTVAELL..LQWFVPSLGGLMVGLEVYRTQRDVAVDRTRALAVLRAHLAPAASSEPTAPs....dLLVLARQIQDLIFHS.RRGQARVPDWFFRRFHAADRVDFQVAMT--rf................................................................
A0A2N4UCV3_9BURK/2-291              ...........NEIDEKQIEPRMLNLLRARTLIYRRAKNVQALCLIISLGFPVVGLIVSA..LLLP.............SKPFIALAALVFSFLEVLLLDRWHRAQLKNAAKLQEDFDCAVLQ..MDWNTFLV..GSRID..PED....VF.VDACKK..........-LSNTDEERLI..NWYP.LVV..KELPLHLARLVCQRTNLWYDSALRKRYRLFLLIGCVALVVVAGFASL..AIDHTMTTFV..LSTLAPMTPVMIWALRECNRQAATCELLDRLNDEVKKLWERSRSGATGQE......ISMRSRELQDAIFNH.RASSPLIFDWVYNLLRRRMEERMNAGAE--hw................................................................
A0A133XEE2_9RHOO/23-312             ...........NDIPTRQASDESRDLLRARHRNYRAAKLTQGLLVLVSILLPVIGVWIGS..QVPE.............IRPYLALASLILLVMETALFDRIQKDRLKRGAKLQEQFDTDIFG..LPWNRFVT..GAPVE..YED....VR.RLSAKP..........-LSEKREAHFL..AWYE.VCI..GRLPLYLARLIGQRTNISYDARLRRRYGGWLLTLTLLFGVALLYAGL..YKGLPFPDLI..MTLIVPFLPVLTWALRERMQQANAAISLTNLNGEWGKIWTKALGGADAMA......LTVESRSLQDAIYQH.RERSPLIFDWVYSIFRSVNEDEAHHAAED-l.................................................................
R5LBQ4_9SPIR/6-291                  ..........d-ELNNNQNREENIELLAAQRVLYNEARIYELLIFILTIVIPTLILFIKI..FFENn..........nlFKEVSNIIPIITMLIYIFIYDK-NKDIKNKAAYIQQLFDSKVYD..INFGIKME..--DIE.nSYT....IF.EKSKKI..........LNSEKEKNKLH..NWYN.IDIrcNKLSSFKLILSCQIINIFWSKELKQKYINIISFIILIPILILLIINI..--KLYKINFI..VSAISYMTPLISFFYINIKNVKNEIKELQNVLSNIEIKLNSDNI------......TEKDIIKIQNSIFKY.RKNSVLIFNIFYNFYKQNIEIILKKYF---gks...............................................................
A0A0D6A0T1_9LACO/21-306             ..........e-ELRKRQNDKNNIKRLAAQRRIYSKAKKINYLIFGLVVLIPIVVSVLTT..-IPSlvf......lqnpNVTLLLHAYTVFMVFLQYFLTTHIEKMKKHAAYIQLESDMKVFD..LKWNDCLL..GPKVD.nTEL....VV.KEFDKF..........--PKKDLSDLN..NWYDlSEL..EKKKREEVIRICQRQNLQWNSTLYKRIN--IGFNILIWGSFGIFVFIipFFRLNMAQMInsAVNFIPLITWILDVNKNYQKNKNILDELKKLISNKG--------------......YSNILAVMIEAKFTEyRQNDSLIPDWLYSLFRRKDNKIHQEAQ---tft...............................................................
A0A250VQU2_STROL/7-295              ..........p-PIVEHQNDPEMLRLLRAASASHARAQRLASGHVVVSTVLAV-GAVVGV..FVPV.............ALTPLSLVGLVWAVVYAVGASTWTKNEFRRAALLQETFDTRLFG..LPWNHVLV..SRGPS..ADE....IS.RLARHY..........---RGSPTRLR..DYYE.I--..QDLPRPFDVVACQLQNLGWGSRIRRRYAGFVRTGLVLWCAAGVLVGV..LNRMPLTDVL..MHWYVPSLGLLLLGVDTYQAQQDTVAAREHARKALLTRTEQYARAGALEAqa..agMLSLARQVQDVLLQT.RLTQARVPNWFFNRFLDTDRADFAAAMDEL..................................................................
A0A2X2Q0C7_RAOPL/1-146              ..........m-------------------------------------------------..----.............--------------------------------------------..--------..-----..---....--.------..........-----------..----.---..--------ALLCHGKNLGWDKSLREVLHVFYLSAFIVSPVAMLVYGI..AMKSGLNEIL..-FYVVFTLPVIRYFLLQFLDNRSSMKRSEKLKKYVEKELSGIRVSGRAEEe....qLGYTLRNIQDEMFAY.RASCPPVPNGIQLIMKPKNERIYVDYFE--tn................................................................
A0A024FGI8_9FLAO/2-284              ...........NRITQKQNEPKFIEFLKAQRVAYSQCKTYQVFDL-ISILMAIVLPIIGM..YKSD.............IVNYLGAFGVLWTIIY-LVTENYRKKKTEQGAKIQEQFDTELFE..IPWNQILC..KNKVN..TDT....CI.DLAKEY..........-----DGNDLS..NWYS.LEV.dSSLPKSIAVILCQRINFSWELKLRKRYVTFLIILLVAYYGIFIGFFV..AKNIGFYDIL..-LLIAPSLSFLIYGVQNSLSLKNHIKSKNETLSQIDEILNNHSENQEMP-......TDSTLRQIQDIIYTE.RTVPEKVPDWFYKLSKSKNENRTDNIIK--si................................................................
F7VIC8_9PROT/16-303                 ........gri------QNDPRYLRYLLARRQVQVEITRLLFTQLMVVIALPAVLAVISF..YWPS.............WKPGTSLVALIIALVDILCIDRMQKASLAKSAKLQEAFDCQVFE..LEWNIFIA..GKPLA..DTF....ID.SKAAGY..........-ACNARAGTVE..NWYP.ERL..SELPPSLGRIAAQTLNMLYDEWLRTHYRVLVGLPVILILGLLIFFAA..VEDVNLTALL..LGVLVPTAPLINWCSREVFRQHDALTRLRTTRALNEALWEQALVGDLPAM.....kADTEARHTQDVSYIR.RSTSPAIFEHLYWIRRSSLERRMSERADS-m.................................................................
A0A136PLV7_9ACTN/1-284              ..........m-----RQNKPEMMALLRAMAICHSRAQRLDNLRLSISVFVSLAGAVVAV..TGTS.............-ATVVTAVGATWAAANAVGLGTWSRGQVRRAAVLQEMFDVDLFG..LPWNEVAA..GERLG..SHE....VS.RLDRAY..........---RGSEKYLR..DYYE.--V..PPLPHPYDILACQQQNLGWGARVRRRYAHSVLAGVAVWMLAGATFGL..VAGLTVAQVL..LQWFVPSLGALLLGLEVYRGQRDVAVDRDRALRILHQRIARAVGSGDAGSa...qgLLLLARQAQDLIFRS.RHEQTRVPNWFFQHFHPADRVDFQAAM---vdl...............................................................
L7FBN2_9ACTN/6-296                  ..........t-PIFERQNDPDLLILLKAASVSHRRAKRLASAHVSLSVLLAALG-VAGV..FAPV.............LKTPGTLLGLLWALAYAAGARLWGRGEMRRAALVQEKFDVQLLG..LPWNTVLA.gGTAPP..AEE....VG.RVARRY..........---TGPESRLH..DYFF.E-A..TALSRPLDVFACQLQTLGWGARVRRRYATTVSCALALWTMAGVGTGL..ARSMTVSDLL..LHWFVPSLGLLLLGLDTVAAQRDTAAAREHAQSVLLAAMREHVSRGRPSAdv..pgLLQLARQGQDVLLQT.RLGQVRVPDWFFRRFQTSDREDFVQAMREL..................................................................
A0A251WAG2_9CYAN/2-293              ...........NNISQEQNTQRSLDLLAAQRQLYSDAKGLQMVSVIMSVPVVIAWSILVA..LFPP.............LAVYAALWGIIATLLELIFFSRLQKFTQEKAAKIQQIFDCEVLQ..FNWASLNC..GVRIE..PET....IV.DASNRF..........KRKKRNLAKLP..NWYP.TSV..SKLPIHQARIICQRSNVWWDAQLRRRYSKWIVFVLFALTIIVLLIGL..IGGLTLEKFL..LAVLAPLTPAFVFGLRQYTEHNEAAVRLDRLRENAEALVQEIINRRYTPQ.....dLERESYSLQTQIFDN.RRRSPLIMDWLYSRLRNEDEEKMNKGAESL..................................................................
A0A1C6SAK4_9ACTN/16-301             ..........a-RITQRQDEPQHLNRLLAYSRDYQIAHRWRRARALGTFALAAVGPFISL..FIPA.............TTDLVAAISAGWLVLGRTLLTGMEQRATHHAARVQELYDTNLFH..LPWNTALA..GRKPA..PED....VA.ASARHI..........----TDDTKYR..NWYS.VDL..GTTPWPADVLLCQRQSMVWSRQEHRAYSATILTTGVIWFIIGLVIAL..VRDLSLADYL..IKIFLPSAPAFLDTIELARQHWQHANARQQAEHKIDDLWQAYVTQPDTL-......AISNCREVQDAAFLL.RRNGPRVPNLFYKLRRARSEANTRAGTA--al................................................................
A0A1C5JBJ9_9ACTN/6-294              .........ds--LLRHQSDPEMMAILRAMSVCHARAQRLDGLRLYLSIAICGAGAVVAF..T-GV.............SATAVTAVGALWAVANAVGLASWSNGQIRRAATLQEMFDVDLFG..LPWNTVAA..GERLG..PHE....VS.RLDRAY..........---RGGEVYLR..DYYE.I--..PDLPAPYDVLACQQQNLGWGARLRRRYAYTVLAGVAAWVSVGVVFGV..VAGLTVAQLL..LQWFVPSLGALLLGLEIYRGQRDVAADRDRAMSILQDRITSAVRRPHDPSvq..aeLLTLARQVQDLILHS.RRGQARVPDWFFRRFHAADRVDFQSTMAN-l.................................................................
A0A1Q8C9Y2_9PSEU/5-291              ..........h-RITDRQDSDAALRLLKAVAVTHSYNQRAQTLSFGVSIALAVAGLLIGP..-GSR.............YGTAVALGGTLWAAVYKMVMEPWAERYLRIAATLQERFDTDVLG..LPWNRVVV..GDRVG..EDE....VS.RLSRHF..........---RGDEDRLR..GYYL.--V..ANAAAPYDLLFCLEQNLAWGSRIRLRFAQMTLFMLVLWSVAGVLLTL..ATGATVAGLV..IGWFVPSLGLLLLCLGTYRIQMASTRDRLRVLGLVRAVVDEHSSPVIASPa....eLTLFARQVQDALYHM.RRLQPRLPAWYFQRYHDEDRSDFQVRMREL..................................................................
A0A1G8IK48_9BURK/2-291              ...........NEIDKKQVEPRMLNLLRARTLIYRRAKNVQAAGLVISLVFPIVGLIVSA..LLLP.............SKPFIAFAALMFSFLEVLLLDRWHRAQLKNAAKLQEDFDCTVLQ..MDWNAFLV..GHRID..PED....VF.ADACKQ..........-LSDKDEQRLI..NWYP.VAV..KELPLHLARMVCQRTNLWYDSALRKRYRFALLTGCVVLFASAGFASL..AIDHTMTTFV..LSTLAPMTPAMIWALRECNRQAVTCELLDRLNDEVKKLWDRSRGGATERE......ISTRSRELQDAIFSH.RASSPLIFDWVYNLLRRQMEERMNAGAD--hw................................................................
A0A432LB44_9BACI/5-288              ..........y--INVKQNEPESLRLLAAMRILYTRAKKLRSFRVLITVLLPIVS-ILGL.kYFPN.............LKEELAFIAGVWLVLNRVLFIEIEKSMVRDAAKIQEQFDVDLFK..ISWNNLIV..GEKIP..IER....IM.KLNEMS..........---QEKEEHLK..NWYP.-GL..KSPDHYFNVLLAQRTSIVWDIEQRKFYKNILIWIVILYILIMLGICF..LMNLPTQTLI..ISFLVPSLPLILHLIEITKGHIKRHESLEKVLPKVTVDVENYSRV--DDD......IVNKCRGYQDIVFLT.RCDVNMVPDKIYWLKRNLFDKIAKDT----neaq..............................................................
R7GKI1_9CLOT/2-278                  ....nkvsvrc-------QKQASAKFYYASKRMFAELKILKVLLYILAIV-PVVLQFIPA.vNSNE.............VMSFAYTVISFALTILNEVLSAFFNNHKESAILEHQLYESEITG..STFSKIEY..-DRES..TNS....LN.ELAIRKg........lPKMHSLEESGK..KYHI.SKV.pDDISDDYSYLYLCRLSAAKTNYLLSRIFVFY-AILLGIVICIFTACI..FWKQNTADYL..-KLIIGFYPLVNPFIKNCASCKKTQKNCVKICADIDNFFADGDASI--ER......LARFYYYTQNIEFEM.MVNKPAIYNIF-------------------pamfkrg...........................................................
A0A257L2S7_9BACT/2-290              ...........NNIPERQNQPKQLERLAAQRELYSSAKKFQIFQIVINIIIPVLLSLLAI..KCEE.............VAPYSAFLGVLFSILDVSFIEQEIKNRREKAAKIQELFDCYVLE..LPISPLKV..ITDIT..VEE....IL.IHYHAH..........SKIPTNVEKIR..DWYS.TAV..SNVPLPIARLICQRSNCWWDSRLRKRYSFSLGVLGVIITLFLGYLGI..HEKLSFNNFV..-LIASSISPFILYIIKQYNDQKEAAKRLDDLVNFSSNIWESSFNMDEHE-......ILDNSRKLQDEIFDH.RSKSPLILDFFYNKLRNKDEEIMNKTADS-l.................................................................
D7E2D6_NOSA0/2-38                   ...........NHIPQEQDRQLQLERLAAQRQLYSDAKNIQNISV---------------..----.............--------------------------------------------..--------..-----..---....--.------..........-----------..----.---..-----------------------------------------------..----------..--------------------------------------------------......---------------.------------------------------syl...............................................................
A0A1X0DT21_9MYCO/1-256              .........mf------------------------------AIRVIVVFVLAGTSAACAV..ALPS.............ARSLIGGVGGAVLLLVAFAASSLEKTWRYRAAAIQEKFDTAVFQ..IRWNRHQA..-DQPN..AHD....VN.RAANRY..........-----RGGRDQ..NWYV.S-T..EGTHRPFDLLICQSSNLGWGASMHFLWAWMLIGAFGVLALTLIGVQV.aILRLPVTDFL..LAVGVPFLAPTKEIVEQSVANFDTARSKASAERKITDLWEQGTSGNDTP-......TEQDVREIQDKILQF.RQNNPYIPDWLDSVFHTKNEAAMRSSAQ--ar................................................................
A0A2A2Z5E2_9ACTN/2-260              ..........w----------------------------WRRIRTWGNVLLALTAPLLAV..FLPA.............GASTRGAIAAAWLVLGKTVLKGMEGSATLRAANIQELYDTKLFY..LHWNQALV..GRQPV..PDD....VS.SAARHI..........----RERGPYL..DWYS.IEL..GDTPWPGDVLLCQRQSAVWSRRDHHAYGAFLAIGGGSWAVAIIVFAL..VRDMTLLAFL..VALFLPSAAALLDTIELAREHWQQSTKRRQVEDDIHDVWNRYQARPGDI-......PAEECRRLQDATYLL.RRDGPPVPKWFYDRRRHETAAVTNDGTT--al................................................................
A0A1T4PVQ6_9FUSO/1-279              .........mk----NRQNEERQLSLLCISELLYGRIKKIRLYYN-FFLVLPILLSFFKN.eIIEKiri......tsenLNTFNLIITLAVSLLY-FVFQFLEKENLTKAVKVQEEFDTKVFG..LQWNDLLA..-DQLM..DIE....IK.ELKEEC..........--KNISKKNKK..DWYNfD--..ENLNDNENIFRAQKSAIVYSRKLRERYLNMLLMIGLIIVVVFIIIIW..--KIPLGKII..SDYFLPFYPIFQKYIDTIFKLKNSIFESKSVYKYLEDT---DTIGK----......DISNLRILQDWIFINnRLHAPIIPTLIYKLERSRLE----------iffrdn............................................................
A0A433SEV3_9BURK/2-291              ...........NNIAIKQVEKPMLDLLRAQRLIYSQAKKMQAIFLVVAFILPFISLINNY..LNLA.............FEAWVAFIALIIAFLEALVFEPWFKQQLKTAAKLKEDFDCNVLE..MDWNSFLV..GKKVQ..PEE....IF.QHARKQ..........-FSEEDEKELL..GWYP.DIV..RNLPLHLARLVCQRTNLWYDGELRKGYRGLLLGGVILIVLVVITISL..WINCSMESLV..LSAMTPLAPIVIWTLKEFNRQKDSLDLLVQLDKEVISLFECSRKNGSEKK......ISTWSRELQDAIYNH.RVSNPLIFDWFYKRCRPAMEGQMNAGAE--hw................................................................
A0A0U2PJN9_9ALTE/3-304              ...........NDINRNQNIERSINMIAAFRQKYSEVKRLGFIQVLMSVWIPIFLALLAL..ALKSqiitgmlgishrdISVYVSIYCVFIALADLFLFNRLIDSGKELAAKIQEQFDTSVFG..MPWNTTLA..GIKPD..DEI....IN.SLKNKF.........yRVNSNKREHLT..NWYN.PKV..ADVDKNKGVLLCQRMNLYWDKAIRETVNERTLISLVCWCTFVLVVAL..IQDLSLQTFL..LTAVCPLIPILIYSLKLITDNRKSITTLTRLKEVLESTWMDATNRHL---......TLAKLREVQNEIYQH.RKTNRPISDRFYWKRKDDFENDAQYSIEQM..................................................................
A0A0X3V6W0_9ACTN/1-285              .........mv----DQQNSVAGLRLLKAIAVAHLYNQRAQAASFIVSIILAVTGLLTGA..-HPK.............LAAAIGLAGACWAALYKAVMVPWAERYLRIAAILQEMFDTDLLK..LSWNRVAV..GDRIG..DDE....VS.RLSRHF..........---HRDESRLR..GYYL.--V..ANAAAPYDVLFCLEQNLAWGSRVRLRFAQMMLGLLALWSVAGILLTL..ATDATVARLL..AGWFVPSLGLLLLCLDMYRTQMASTRERLRVLALVRAVIDDPTSTLIATPs....tLAVFTRQVQDTLFHM.RRLQPRLPTWYFQRYHDQDKTDFQVKM---ldl...............................................................
A0A369XUS9_9FUSO/2-286              ..........i-DIKVKQNEENILKLLFSARINYNKASKLNNYLWLLSIITGIFSVTNYF..DISS.............--ENNS-IILLVLVIIGVILHYFIKQNIERGAETKKLIDETLFE..FPTKF-SS..SNILK.iKEG....AL.KLQEKYpeey.erqikNRGDSDARGVK..DWYD.PK-..ETTNFNKTIFQCQKENIFWDKNLLNIYKKLLMSIVFILFVFLL--FD..LYNNSLNIVL..FH-IFGFFNFLSILVRDLHSIKTYFTCSIIMDEKVDILGKNNVI----N-......EIVVLKELQDKINER.RSLLLIVPDFFHKINSKKLH----------kkwksll...........................................................
A0A328YS72_9FLAO/6-297              ..........k-HILETQNENFHIDQLLAQKKIYSNAKILQGILIFITIPLPIIIALILK..FYPTl..........fdEKHWIFVLYLVLASLFEKVLENYVDRYKKLAASIQEAFDTKVLN..IEENESLN..TVNID..NEL....IR.EKSKGP..........RKKSKRVADVT..NWYS.LNI..ISIRTNIASILCQRTNVFYDFSVRKRYNCAMRIIVVLTFIILMVISL..KNDITLKLFL..IEVVIPSIPVFMFAYKEINSNTESIDNLEHLRNLIEVNLNNLTIESNI--......QKPLLRKIQDRIYSN.RILSPLIPDFLYYLIRPKLEDQMNYSVEQ-i.................................................................
A0A372FXZ7_9ACTN/6-293              ..........k-SLLSRQTEPEMMALLRAMSVCHARAQQLDNLRMVLSILIGAVGAVVAI..TGV-.............SSTVVTAVGALWALANAVGLGAWSRGQLGRAAVLQEMFDVRLFG..LPWNTVAA..GDEVS..AAE....VS.RLHRAY..........---RGDETYLR..DYYE.--V..PHLPRPYDVLACQQQNLGWGARIRRRYSHVVLGGTALWAVFGVVFGV..TAGLTVSQLL..LQWYVPSLGALLLGLEIYRSQRDVATEREHALAVVQARITATIERCGEATt...aeLLVLARQVQDLVFRS.RQRQARVPDWFFRRFHLVDRHDFQAAMG--tl................................................................
D0GIV8_9FUSO/3-259                  ..........k-SIYELQNEKDIQKCIIIQKNYYTKAKAFNNFIFIFNVVIIVLFSILSL..LSET.............MKAISILISMIIPYIN-NIFEKEKSKIQKEASDVQQYIDTYLYS..AVLNEESK.yRNQKE.wNNT....LK.KSEMD-..........KLVSKCDEMKE..NWYS.D-Y..SQKKDVEQIYLSQKENINWDNNLRNNYLKLNYVSFFILLIAIFIVVI..LFNLTFVKSM..-LYFAWLLVIINYFQKNISMLKNDIKNQEIMKEIAII-IENNFEKENFKIe....dILELEIKLQDK----.------------------------------i.................................................................
A0A428YTF7_9ACTN/1-277              ..........m-------------NLVRAMAAAHARVQRLEGGRLLASVLVAL-TSIVAA..LTPS.............LAGTVAAIGAGWALLQGWGYSVWIQRELAQAASTQELLDVTLFE..IEWNPVVA..GDPPS..PAE....VS.SLAQRF..........---RGPDDMIV..DYYEiHGV..QDLPRPFDVLACQLQNLHWGARVRRRFAGTVLAVLIGWLVAGMLVGV..VLQVPLGRLL..LIWFLPALGALLMASEIYRRQRDTAATRARVFALVRRRIDAHLEQPGPVG.....dLLVLTRQVQDVIFAT.RRTQARVPDWFFLRFRPRDRIDFQREVAEL..................................................................
A0A1K1NT26_9FIRM/5-284              .........qi--ISNRQNEDLLLKIQYASRRYFNSAEKFNYLSWVLCIASAAMIFVPDS..-APE............lFSNGIPAVLEVFAFVTA----CIFNSKLKNAASLRNYFDSYVLM..IDEDSYTN..IHKQK..LRE....IAlATYNRYkkea.dihihNTGRDKPPGVK..NWYEfK--..NPVADRQAQFECQKQNIWWNKKMVKNRMILLSIILFILISFFVTMFA..LFKSDALSII..VCAIGIILKVVERIIEHYSYHKTSIK-IEAIQSHAERELTAETVK-----......------ELQE-----.------------------------------lingrreipvleiniihklkakrysssyeet...................................
G8SGB9_ACTS5/15-306                 ..........p-SVRQRPIDPALCHLLRAIAVSHARVRRLVALRIVISAVLAGAGLVTVF..AGAStg.........kpLSVTLSVVGVLWALAYSLGLASWADRELHRAALLQESFEVRFFQ..LPWNCMLA..GEEIP..AED....VR.HLSSRY..........---RGDPPR--..DTYE.--M..PNLPRPFDVLVRQQQNLSWGSRVRHRYAQVVMFAMSGWAALGLFTAI..ARNSTITDLF..VQWCVPSLGMFLLGWDTFREQRRVAEDRKRVCGNSRGRCLQLAPAGLDPVvn..qdLCRMARQVQDQLYLS.RSRAPRVPRWFFQRYYTQDSSDFTAGLAE-a.................................................................
A0A2T4V0Z5_9DELT/16-299             ...........NDIGVRQDLEENLERLAALRALYSRAKSVRGASALVATLLAVASPLVTL..YWPK.............GSAGLALGALVWALVELVLLDGLEEKNRQEAALIQEEFDTRVFG..LPWNEAL-..GARPA..PEL....VV.AAGKAG..........----KGDPKLK..GWYA.-DV..SRLPRSLAILLCQRSGLAWDHRSRAWYQTFLAAVALLLALGAVALAM..GTRQSLTEFL..VNFALPVLPAVQHAIKTFKAHRRAGAEQERLRDELASAWEGGLASGGNL-......HEAQLRRVQDRLLLL.RREQTPIPDVLYRLLRPASEATMHEATRR-l.................................................................
C6D7P5_PAESJ/1-191                  ..........m-------------------------------------------------..----.............------------------LLNNREQNYRLKAATLQEKYDNNVFG..LMENKTLI..LKMIS..PEE....IN.FISENQ..........-----KENEEA..VYYS.-NL..SSGDNITNILISQRQNVLSDRILRKMYLNTFKVLLTIVLLLCISFGM..LLGQSLTEFL..IGMLLPTISLISLITQHIKKLSDEIKKNEQVGQLIEIDFQNYCSSKTDHTvlnmekYMSQCREYQKT----.------------------------------ysqk..............................................................
A0A1N6JYV9_9BURK/2-290              ...........NEIARRQNEKQMLAVAWERRRVYDHVKVVQGILVIVSLFMPVLGVIVAV..WAQS.............LKPYVALASLIVGCTDAAFVDRWIKRQMKEGARLQEHFDCSVLE..LPWNRFLS..GSPID..AED....IA.AYRQTC..........--PPGDGGAMR..DWYA.PSV..SRLPVPAARLACQRSNLRYDLSLRRRYCTIVTIAMVVVVVAAFAIAV..VQNPSMSSFV..LSGAVPVMPLVLWGVRERNRQLDASALVERLKAHVEKLWESVLAGAGDNV......LTMSSRELQDAIFSH.RVSSPLVFNWLYSRLRSGLEQQMAGGVE--hs................................................................
A1AY84_PARDP/4-293                  ...........NNIAREQNSEPVLRFLKARTIVYRKANLLVGLQILLTAVVPALMAVAGI..WLLD.............WKSLFALAGLSIALVDMLIIDRRLGKLSVDAAKLAEEFDCRLFS..LPWSEILV..GQRLS..PET....VQ.GYVVKF..........--RQKKEPAIL..NWYP.EAV..STIPRYLGVLLCQRTNLWYDSELRSHYAALIKWAGVVGFILCFVLAW..RLNYTLQTTV..LSIFSPMFPFFAWSIRTYWRQTDVSAAQARNLSSAETLWKQAVRGTLSET.....kLWPEIRDLQNAIYAR.RSASPLILPFLYSVLRPGMENRMSVAAEK-f.................................................................
G7M070_9CLOT/8-313                  ...........NEIINKENLPENLDKLYAQRQIYSDAKVIFGIQIVVTVVFTIVLSLVSN..FFADfittyl.slskelFKSIIFIISALITILDLIVITPYLNNQRILAASIQDSFDCDVLS..ISNNPIKI..-SKPD..VET....IG.KYSLKFi........kKRNEKDKSNMI..NWYYsTNL..DTIKLPFASIMCQRTNCWWDNYLRQSFVKFIISISTFVFLLVTIISL..FKELSIPSFL..LNAFSPFFCLLTFTIKQYKDNCKSINNSNKLKTCCDNIWADILNKTKKED.....eLKDLSRKLQDEIFQS.RSTNPLIFDWYYKRSRNKQEYDTNYTLE--im................................................................
A0A0A0BXW2_9CELL/12-297             ..........a-DIAKAQNADPNLRLLLAQRRFYSRAKRWAGVRGIGTGIIAVAAPLLAA..FVAS.............AAVPAATTAAIWYVLSRVLFRHLERRDATRGASVQEQFDTAIFG..MP--PIAV.rEPRVL..PED....VT.RIVGTR..........RRPAYAVERLR..NWYP.IQ-..EGVPGRIAIAIAQRANVSYTRRLLERHATLWLWVLVGWSLVAVIISL..LARFSLATFL..LAVAIPVLPPLVDAWDEYVSVRAASREREALANEIHDAIAADAAAPIPP-......--EHLVAWQSQLFAL.RRDAPLVPDWLYGLLRRGNEAEMSEAAET-i.................................................................
A0A1H9RI66_9BURK/16-305             ...........NEIIHDQNRDDRLDLLRAQRTYYRRAKRLQTMFLILALILPWVGTIWGT..DDPK.............IRPMLALTSIMLLLFEIGLGTRVQRDWVKTAARIQEQFDTEVFQ..LPWNQFVV..GSKVD..PEV....IR.AVTLKP..........-ITAAQRKKVE..GWYE.HCV..GSIPLLLGRLICQRTNITYDMRVRKAYATGWLVLASVLIAFLMYRGV..HEGLTFSDLL..LNVIVPFIPLAAFVLREHRKQSDTVETLTTLKSEVDKLWAKALKTPSSAE......LAQDSRNLQDAIYRN.RTSNPLVYDWVYWLRRKLNEDLARHGAET-l.................................................................
A0A2H9U5B3_9GAMM/1-132              ..........m-------------------------------------------------..----.............--------SLLVVVFDLFVFTPWVKKWRDNAARIQEVFDTNLFE..LEWNEIVV..GKKPE..YEL....AY.EKAKKY..........GLDAERIVNLK..EWYP.TVI..DKVTSIFGVFFCQRVNIYWDTRMRLRYSLAVRMILVLIELGVMGYGI..YTK-------..--------------------------------------------------......---------------.------------------------------kdm...............................................................
A0A395LNZ9_9SPHN/2-292              ..........q-DIAGRQNKEPYFGLLQARQWLWKIAERWLVIQMVAVIPVPIIGAIIAL..SVPE.............HRASVAVGAILLTLLDALFIDRRYRHAVKVAAKASEAYDTKLFK..LPWNELAA..GPKLQ..PEQ....IT.SARRTW..........-DEKRSSDQLI..DWYP.TSV..DNAPFHVARLICQRVNVTYDSALRMIYSQILFWGAILVALALTGIAL..LSDASLSEVL..LSYLFPIAPLLIFAIREGFRQRDAAEANQQIRNAAQAVVEDVIERGCTAE.....eCTHKSVQLQAAIYTR.RALNPLVAPGLYGLFRNKLEKDMNEGAD--hw................................................................
A0A0M8WQN4_9ACTN/6-296              ..........t-PIFERQNDPDLLILLKAASVSHRRAKRLASAHVSLSVLLAALG-VAGV..FAPV.............LRTPGTLLGLAWALAYAAGARLWGRGEMRRAALLQEKFDVQLLG..LPWNTVLA.gGTAPP..AEE....VG.RVARRY..........---TAPESRLH..DYFF.E-A..TALSRPLDVFACQLQTLGWGARVRRRYATTVTCALVLWTLAGVGTGL..ARSMTVSDLL..LHWFVPSLGLLLLGLDTVAAQRDTAGAREHARSVLLAAMHEHVSHGRPPEdv..paLLQLARQGQDVLLQT.RLGQVRVPDWFFRRFQTSDREDFVQAMREL..................................................................
U2SIW5_9FIRM/4-221                  .......kysd-------------------------------------------------..----.............---------------------GHISAHKKHAASIQQYIDVTLFA..SAIGGTKSewGELPN..KTD....LA.ETISEF..........--SGEDTSDMK..NWYS.D-Y..SSLPGEAQIFHCQRENVRWDYGLHKSYICLQLGILLAAVVAMIVTMF..IVNPDFIKLI..-CILSWLTPLAEYTYSICKEVFESISLLRKIDSFCDQIENKLSGDNSVS-......VKEELIDLQYKIRER.REVGFLIPDWFYKMRKRKHQKQEDSIAE--ti................................................................
A0A2X2PWT1_RAOPL/2-140              ...........NAIYTNQSTRENLDLLYAQARVYDRVKNWNRLNFLFSIIVPLLLSLVTV..YNRSrgfv.....dselLSSLLGLYGLLVLTFN-IAISGHISALRRKAASIQEMYDCRVLG..IRRNELKV..-EEIP..RDD....II.RAAAYF..........RDSPEKS----..----.---..-----------------------------------------------..----------..--------------------------------------------------......---------------.------------------------------tkaiw.............................................................
A0A2N1F5Z9_9FLAO/3-289              ..........e-EIINKENYSENIELLAAQKQLYIIAKRVFALQIILTSVIVVALSIINL..FTDT.............-GKLLSVYSVLIAFLDLLLIKDLIKNYKDKAAKIQEQFDTIVLS..IPPNTLIE..--KVD..LEE....IG.RYARKH..........KEIDPTYSKLK..NWYS.ISI..KEINNSIAKIVCQRSNFVYDYTLRKNYNLALSILIGAMCLTVIVLAI..INESNLIDFF..LVGVLPILPILMLFVQVLKDNKNSNTNLVKLKQVANESWNKVLNNQPID-......ISQTSRNLQDMIYQN.RINSPLIFEWFYNLKRKQLEDEMYYSVD--rl................................................................
A0A176T6B5_9FLAO/6-297              ..........k-KILNLQNQDNQIDDLLAQKTVYSNAKNYQGLLIFITVPLPIIISIIVK..LDPKl..........idQSSYIFALYLVFAAIGEKIVEKIVERLKNIAASIQEQFDCEVLD..IPTNETLN..SLFID..KET....IR.RNSKKA..........RKNKSLVQKVT..SWYS.LNL..KDVKTNIASLLCQRTNITYDYSVRKRYKSTVLVLSILTVVTLFLLSL..FNDLSLQTFL..IEVILPSIPVFMFAYKEINSNTESIDNLNHLRNLIESKLNDVNINSEID-......-QELLRKIQDRIYHN.RVLSPLIPDFIYYFVRTKLEDEMNYSVEK-k.................................................................
A0A1I4J5Z4_9BACI/2-301              ...........NSIVIKQNEQKSIEILAAQRLTYTQGKKLQTSEFFISVVLVVFFNLLSL..VIQNfaeg.....ylteLNIFNAFVVSIALVVSEAVLNPNISKRKEKAAKLQELFDCYVLG..IDHNSIKT..GVLPD..YES....IN.SLYKKF..........ISNKGDINLLQ..DWYS.KDV..ENVPLEYGRIICQRSNFWWDVTLRLKYRQIVIISAIFLLLFLLSVTS..LVGLTFNSFL..INVLMPFLPALILVIRRVNQNSQAIISKKYLKEKVEEVWEDIFVNIKSDS.....eLYDIARELQNEIFEN.RKTNTLIPEFIYMKMRSDQEEDMGYSVNK-m.................................................................
A0A0L0AT10_9ENTR/1-282              ..........m-----------------AMRRTYSQVKFVNWVVFFLSVVISVAIVIFTT..VIKKmglf.....phltIAPYLGYYGIIVLLIT-IVFSTVISSMKKCAATIQEMFDCDVLH..IPWSELKV..GKPVG..RED....IF.KSSRYY..........-KKRNKKDEFL..NWYL.NKD..YEANENVMALLCHAKNFGWDKSQRDVMSKIYFITMLVSFLILLAYGL..WSKSSLEDFL..-FYIVFTLPFFRHVIMLYVENKKSISRIIRVKDFIEKKIQSIKISGMINNd....iLSHELRAIQDEVYAH.RSTSNPVPNCLHRFMRKNNEAIYDDYFE--dn................................................................
A0A132MWY8_9ACTN/16-301             ..........h-RICQRQNETRFREMLAAYSYRYRVASVYRRLRVTGTIALAALAPVFSV..LWPQ.............AAPTLGAVAALWLVLGRTLLDAAEQAHIDRAARIQEYFDTHLFG..LPWNPDLG..REELV..CED....IA.TDARRG..........--PRPDSDRYQ..DWYD.D-D..GATPWPLDVLLCQYQNAAWGRRNHQAYVPWLAAAGAAVFLLGLALAI..TRHMSVSTYL..VQLLLPTSPALLDLALLARDHKRHATAKQRVEDDINNLLNRYLTGEQV--......TATDCRKIQDAIYRL.RRTGPRIPHWFYRSQRQKDTRATAASIQQL..................................................................
A0A0F0LVQ3_9MICO/1-285              ..........m---RERQNHTDALRLLIAQRRIYNVAKRWQSARWVGVMIIGIAAPVLAI..VVPQ.............AAVVVGAIAGAWLFFGRTAFAWGETLKMGRAAAVQEDFDRYVFA..MPVTIART..-TAPT..RED....IA.AIAGDRa........qTLTIARREKLL..DWYP.ISL..-GASGATSVAVSQRANAAYSDRLLRATVAVWASASLGWALLMTIVSL..AAGLSLGTFL..VGVLLPVLPACLDAFEYIRSTFLAARDRRDLAATIESRLLTGAALV----......DGQELLVWQERIYEL.RQTTPQIPNWLYRLLRPRNEAAMHAAAED-l.................................................................
A0A1C4RA98_9ACTN/24-215             .plepctgrag-------------------------------------------------..----.............--------------------------------------------..--------..---PS..ADE....TS.RNARRY..........---RGAPGKLR..DYYE.I--..RDLPRPFDVVACQLQNLGWGARIRSRYATAVQTGLFVWLAAGAVAGI..LTQMTLTSVL..IHWYVPSLGLLLLGVDTYKSQLDTKAAREHARWALRSRIEEYARAGAPPAem..peVLSLARQVQDVLLQT.RLTQARVPDWFFNRFLEADRADFAADMDEL..................................................................
A0A429B461_9ACTN/16-310             ..........r-AIHERQLDDAMLLLQRAAAASHQRGQLLEAVRVTAAVALAGAGVLVTL..-IGH.............GRAPVSIVGFFWFVVSAFLLKGIAGNTARQGALLQEMFDTALFH..LPWRATTA..GDPIP..QPD....VR.RLARKL.........pRGGAKDKRITD..GWYD.P-T..NDVHHPYDVFIAQEQNLAWDARLRRRYSHLIATTTILWTTIGLVAGL.aVADATLLDTL..LSFFVPSLAAYQISYEIWSGQRKVADERDRLAKIVNTELHHGRPGPIPDDew..hrLRNVARDVQDGILRT.RLDTTRVPEWFYKRFRDDDERDFGDTAE--gh................................................................
A0A3P4B7V8_9BURK/2-291              ...........NKIDQKQVETRMLNLLRARTLIYRRAKNVQAVSLIISLVFPIIGLIVSA..LLLP.............SKPFIAFAALMFSFLEVLLLDRWHRAQLKNAAKLQEDFDCTVLQ..MDWNTFLV..GNRID..PED....VF.ADACKR..........-LSDKDEQRLI..NWYP.LAV..KELPLHLARLVCQRTNLWYDSALRKRYRRVLLTGCVVLIAAAGVVSL..AIDHTMTTFV..LSTLAPMTPVMIWALRECNRQAATIELLDHLNDEVKKLWERSRSGAKEQE......ISMWSRELQDAIFNH.RASSPLIFDWVYNLLRKQMEERMNAGAD--hw................................................................
A0A0A6UR84_ACTUT/1-280              .........ma--------------------VSHVRVRRLAAVRIAISVTLAVAGLGAVF..AG-Sinst....pfirsLSLTITVAGAVWALTYAIGVGTWAHRELHRAALLQEMFEVRFFQ..LRWNHVLA..GDELP..AED....VH.KLSSRF..........---RGTEESLR..TSYA.--M..PNLPAPFDVLARQQQNLAWGGRVRRRYAKAVLAAILAWAACGLLTAM..IRGSTVTDFV..VQWCVPSLGMLMLGWDTFRDQRGIFTERRRVARWSRARCLQSAALGQDPLvq..qdLWLMARQVQDQLFLT.RRRAARVPAWFFHRYHTQDSSDFTAGLAEM..................................................................
#=GC seq_cons                       ............pI.pcQsp.p.lphLtAtphhYspAcphpthphhhslhlslhhsllsh..hhss.............htshluhhuhlhhhlthhhhsthtppthcpAAplQEhFDsplhp..lsWNphhs..upchs..s-c....lt.phupch.............ptsppplp..sWYs..th..sslsh.hshlhCQ+pNlhWssplR+pYsthlhhshllhhlhhlhhul..htsholsshl..lshhlPhhshlhhslcphppppcshpphcclpshlcphhpphhsst..........hhp.sRplQDtlapp.Rtssshl.sahaphh+spp-tphptshp..h.................................................................
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