GenomeNet

Database: Pfam
Entry: Saf_2TM
LinkDB: Saf_2TM
Original site: Saf_2TM 
#=GF ID   Saf_2TM
#=GF AC   PF18303.2
#=GF DE   SAVED-fused 2TM effector domain
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Burroughs AM;0000-0002-2229-8771
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   Laks
#=GF GA   29.50 29.50;
#=GF TC   29.90 36.30;
#=GF NC   27.50 29.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   26590262
#=GF RT   Comparative genomic analyses reveal a vast, novel network of
#=GF RT   nucleotide-centric systems in biological conflicts, immunity and
#=GF RT   signaling.
#=GF RA   Burroughs AM, Zhang D, Schaffer DE, Iyer LM, Aravind L;
#=GF RL   Nucleic Acids Res. 2015;43:10633-10654.
#=GF DR   INTERPRO; IPR041167;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Predicted pore-forming effector domain directly fused to
#=GF CC   predicted SAVED sensor domain. Binding of a ligand via the SAVED
#=GF CC   sensor is predicted to activate the Saf-2TM and initiate a cell
#=GF CC   suicide response. Component of a class of conflict systems
#=GF CC   reliant on the production of second messenger nucleotide or
#=GF CC   nucleotide derivative [1].
#=GF SQ   21
#=GS A0A2U2DQC0_9RHIZ/3-152   AC A0A2U2DQC0.1
#=GS W4QZT7_BACA3/10-155      AC W4QZT7.1
#=GS A0A1G7I4J2_9PROT/3-155   AC A0A1G7I4J2.1
#=GS J2GUT1_9SPHN/1-112       AC J2GUT1.1
#=GS A0A0Q6MFZ1_9RHIZ/8-160   AC A0A0Q6MFZ1.1
#=GS A0A0X8GNB7_9BURK/7-154   AC A0A0X8GNB7.1
#=GS A0A3N9U3C1_9VIBR/1-154   AC A0A3N9U3C1.1
#=GS A0A1V8MAM2_9GAMM/5-149   AC A0A1V8MAM2.1
#=GS F4GRJ5_PUSST/3-155       AC F4GRJ5.1
#=GS C5T076_ACIDE/4-152       AC C5T076.1
#=GS A0A285UUJ7_9RHIZ/3-155   AC A0A285UUJ7.1
#=GS A0A0S3EW60_9SPHN/2-149   AC A0A0S3EW60.1
#=GS D0Z5J0_PHODD/8-156       AC D0Z5J0.1
#=GS A0A3R8MM79_9GAMM/29-172  AC A0A3R8MM79.1
#=GS A0A0Q8BVH6_9RHIZ/3-152   AC A0A0Q8BVH6.1
#=GS A0A0D8CXJ8_9GAMM/2-154   AC A0A0D8CXJ8.1
#=GS A0A327M1P5_9PROT/8-154   AC A0A327M1P5.1
#=GS A0A1I4RIV7_9PSED/1-146   AC A0A1I4RIV7.1
#=GS A0A2A3K0K4_9RHOB/3-155   AC A0A2A3K0K4.1
#=GS Q07GQ9_ROSDO/3-155       AC Q07GQ9.1
#=GS M4S6W7_9SPHN/2-149       AC M4S6W7.1
A0A2U2DQC0_9RHIZ/3-152              ......r-ETIDWAFREFIRFLLRPKGFEVR..IAAGCVAVLVVLLGW.....NFVVKATAPEG.-YSIEV--GSTNaIPEWVQWPLVAIFSA..IFVFCVFMGWRRSTRENELRNRKKVIVIEGRGLREDDGSPLTEAVPA.DIVGNRIG.VLLDLRQR.KDGIVVDPEELL........
W4QZT7_BACA3/10-155                 ......v-ILVIGAIIFFRNMVIQKKEQGYAavLFTTGIVLITNAFGTf...fDNVMQILTMLQ.SNSVEDSLRIQE.SFSDVNYTSLFIGVV..LLLTG--WLFSRY-----IQNKMFILNINGYYDRRIEGHHNELSLSTfEFKEREVD.FVRLFKIN.----KMTPTLA-a.......
A0A1G7I4J2_9PROT/3-155              .......KRHFDNFLTKLIDWWFRITAVERY..LIGTGVTLLIAIFGG.....MPLILELLRFI.LGAVPERIFHFEaELETIDVLIFGAALL..LIVVGIAFAIARFIREARAQSKLRNIVIEARGLRDDDGNPLADTVAK.HQKGTVVP.VLLDLRNR.LDGQVIAPDRAL........
J2GUT1_9SPHN/1-112                  ......m---LNHFLRSLIDWVFRRRSVGAS..LIKVGVPLYALVLV-.....SLTIGVRVPTK.DGPVVFSWDTSG.GAAALSWGVFIVATV..IVLTGLLLVVRDV----RRENRDKVIVIEARGLRDWQGEPL------.--------.--------.------------g.......
A0A0Q6MFZ1_9RHIZ/8-160              .......WNTLDFVVRSLVSWFVRARHAESW..IFRGAVAALVAIHGA.....NWVFKYSGTIG.GESGSIEFGTAGaVPDSILWIITVVCIA..LMLGSAVWAWIRYANEQKRLARKKVFVIEGRGLRDDDGSSLKSAVPE.SITGTRID.YMLDLRQR.KDGVIVEPEDLL........
A0A0X8GNB7_9BURK/7-154              ......l-NRILNILQEFGVLYLRRTPAGM-..FMKYGVLLMLGGPLL.....NISVSSYFKDDkGNFIKASLNSSE.PIWWISAGCFALGFI..FTAIGGYLAWQNY----RIQQRKRIIAIEVRGLTQSVDSPLVAAIPI.LILGQREE.LLIDVRNL.VDGTPAQRQKAL........
A0A3N9U3C1_9VIBR/1-154              ......m-SLFHSVVTKAADYFFRKRSPALI..VFRGGISLLTMTLLG.....NFAFNARYENT.HQAFSINIPSSD.LPISLLTVGFYCGVA..LVVIGLIWEIHRDVAERRKLSRQVVISLEERGLVNTSDSPLSTFIQL.QYKGKRVDpIVIDIRDSlANGAVNYPVP--al......
A0A1V8MAM2_9GAMM/5-149              ....lvy---FKSAIWKFILWLMRPKNI---..IFTTGRLFLVTGFGGgalfsNFSIKH-LSDN.GNNIVVDFSSDQ.VPYLLQHGLWLLGFIgaLILIA-EIIYISL-----GRSRTLVIGIEHIGLKKRISTPLSA----.-FLGRAET.IPIDLTTCyENDKVSNPTKAL........
F4GRJ5_PUSST/3-155                  .......WDTVDFVIRSAARWFFRIRNAENW..IFHGAIAVLIVIHGA.....NWIFKYSGPIF.GTPSSVEFGTVGsIPDGILWSVTAVCAL..LMIASPVWAWKRYVNEQKRLSRKKVFIIEGRGLRDDDGSPLKTAVPD.SIVGTQMD.YLLDLRQH.KDGRIVEPEDLL........
C5T076_ACIDE/4-152                  ....lnw---LMGIGTQLVTWWVRPRNIGLG..MMRWCGMVLVAALSG.....GLLVQLQAGA-.--EYRFMFSTAEgTPAVILYAVSAVALL..GFIVGAVLAGHAHVQDAKVTQVSRVLVAELRGLVDTSDRPLTKAVPP.TLRGRIED.CLVDVRAQ.LSG---------apdvpaal
A0A285UUJ7_9RHIZ/3-155              .......WNTLDFVVRSLVSWFVRARHAESW..IFRGAVAVLVAIHGA.....NWVFKYSGTIG.GESGSIEFGTAGaVPDSILWIITVVCIA..LMLGSAMWAWIRYANEQKRLARKKVFVIEGRGLRDDDGSSLKSAVPE.SITGTRID.YMLDLRQR.KDGVIVEPEDLL........
A0A0S3EW60_9SPHN/2-149              .......KKHFDYFIRSWIDFIFLRPLPGMR..LIKWGVTLILATFA-.....GFALTVGIPTE.NGRIDVSFDSGAgIPAFVLALVLTLASL..MIIGGALWLIVDL----RRESRKQVLAIELRGLRDMSGQPLISAVPT.GIMDRRVS.LLLDIRQG.ADGVLLSPEQAL........
D0Z5J0_PHODD/8-156                  .......MYRLLHWGDLLFKWYTRPKSK---..LFTIGKFLVVSGLSSi..glTTALKIAFITPeGYELTASFFEND.----TGIFILLISSC..FIIVGFFLIIYDALLTIKDSGKANNILVEHIALFKPLSSSFLSTVTK.-AKGKMRC.VKIDLSEYyRDGVLSEPSDAV........
A0A3R8MM79_9GAMM/29-172             kawfqds-------ATRALNWMTRRRSAGGR..LLYVGGAITACTLST.....DWLVSASVGKA.--SFVLSTGEGQ.-PALITKIALFIGLG..LVLVGAILSVSHHVAAARRVARKLIVSVELRGLPGASNATLRDAMSR.DYRVQCSQ.VFLDVRD-.------------flrggeie
A0A0Q8BVH6_9RHIZ/3-152              .......KDTLDWALREFVRFLVRPRGFEGR..IAQGCVPILVALLGW.....DWFVKFAAPDG.---HSLELGSANtIPEWIQLPLIVLFST..IFTFCMLISWRRLVRDNELRNRKKVIVIEGRGLREDDGSPLTEAVPA.DIVGNRIG.VLLDLRQR.RDGIVVDPKELL........
A0A0D8CXJ8_9GAMM/2-154              .......KKAISYFIEKAADWFFRKRSPALI..VLRVGGSILLATLVG.....SWALTLVYKDA.ERSLELGYQSSS.TAQLFFTIGFFVGIA..TIVWGAVWEYQRYRDESKRNAKKKTIVIEQRGLVDTSDSPLGEYVKR.NCSWLVDT.IVNDIRERiIDNVITRPDLAL........
A0A327M1P5_9PROT/8-154              .....nq--LLRRAVAAFIEWRFRKRSASLA..LIGLGVSILVAALG-.....----GLAVRFR.SGDTEFEFGGGA.SF-ALSAVGLAVGAA..LVGLGTWLLLQDRREEREARERKRVLVVEQRGLQRRFSTALREALPR.ALVGQIVE.KVIDVTPYfRDGVLAEQAA--af......
A0A1I4RIV7_9PSED/1-146              ......m---INYFLRSLIDWIFRRRSTGLT..LVRIGVPLLAVVLV-.....GLTIGVEIPTS.QGPLVLKWDSSG.STGVLSYGVFVIASL..IVLIGLGLIIRDI----REEGRKKVIVIEARGLRDWQGQPLASAVPW.SVPGRREQ.VIVDLRQGlVDGQIVSPDVAL........
A0A2A3K0K4_9RHOB/3-155              .......KRHFDNFLTKLIDWWFRTTTIERF..LIQTGVGLLIAIFAG.....APLLLQLLRFF.WGSLPEGAARLEnKLEDIDFYILAVGLV..LIVSGIAFAVARFIGEARAQSKFRNIVIEARGLRDDDGNSLADTVAK.HQKGSVVP.ILLDLRNR.LDGQVIAPERAL........
Q07GQ9_ROSDO/3-155                  .......KRLFESFATKAIDWWFRVSAIERF..LITTAVALLIAIFGG.....VPLIAELLRIA.IGAVPEGYLNAQgKIDAVAGWILGIGFL..MIVVGLGLAIARFAGDAKSRSKKRIVVIEGRGLRDDDGAPLEGTVGK.QVEGQVVP.VLLDLRRR.MDGKVIEPERAL........
M4S6W7_9SPHN/2-149                  .......KKHFDYFVRSWIDFIFLRPLPGMR..LIKWGVTLILATFA-.....GFALTVGIPTE.NGRIDVSFDSGAgIPAFALALVLTLASL..MIIGGALWLFVDL----RRESRKQVIAIELRGLRDMSGQPLISAVPT.GIMNRRVS.LLLDIRQG.ADGVLLSPEQAL........
#=GC seq_cons                       ........phlchhlpphlcWhhRt+ssthh..lhpsGVslLlushus.....shslphth.tt.ttslshpasous.hsthlthhlhsluhh..lllsGhhhthtchhtpt+tpuRK+VllIEtRGLR-ssGsPLtsuVsp.phhGpths.lllDlRpp.hDGhlhpPpphL........
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