#=GF ID   Sld7_N
#=GF AC   PF18636.7
#=GF DE   Mitochondrial morphogenesis protein SLD7 N-terminal domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF07592
#=GF GA   25.00 25.00;
#=GF TC   26.50 25.40;
#=GF NC   24.70 23.70;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 81514348 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0616
#=GF RN   [1]
#=GF RM   26249346
#=GF RT   The quaternary structure of the eukaryotic DNA replication
#=GF RT   proteins Sld7 and Sld3.
#=GF RA   Itou H, Shirakihara Y, Araki H;
#=GF RL   Acta Crystallogr D Biol Crystallogr. 2015;71:1649-1656.
#=GF DR   INTERPRO; IPR041564;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The initiation of eukaryotic chromosomal DNA replication
#=GF CC   requires the formation of an active replicative helicase at the
#=GF CC   replication origins of chromosomes. Yeast Sld3 and its metazoan
#=GF CC   counterpart treslin are the hub proteins mediating protein
#=GF CC   associations critical for formation of the helicase. The Sld7
#=GF CC   protein interacts with Sld3, and the complex formed is thought
#=GF CC   to regulate the function of Sld3. Although Sld7 is a
#=GF CC   non-essential DNA replication protein that is found in only a
#=GF CC   limited range of yeasts, its depletion slowed the growth of
#=GF CC   cells and caused a delay in the S phase. Structure analysis
#=GF CC   indicates that the N-terminal domain of Sld7 binds to the
#=GF CC   N-terminal region of Sld3 [1].
#=GF SQ   46
#=GS J8PHV2_SACAR/2-125       AC J8PHV2.1
#=GS SLD7_VANPO/2-142         AC A7TQ35.1
#=GS G0WC75_NAUDC/48-175      AC G0WC75.1
#=GS A0A1G4KGX9_9SACH/1-122   AC A0A1G4KGX9.1
#=GS A5DUC8_LODEL/7-161       AC A5DUC8.1
#=GS A0A1E5RA54_9ASCO/4-125   AC A0A1E5RA54.1
#=GS A0A1E5RUL5_HANUV/2-126   AC A0A1E5RUL5.1
#=GS A0A8H7GQB4_9ASCO/2-86    AC A0A8H7GQB4.1
#=GS A0A1E4RGX3_9ASCO/3-109   AC A0A1E4RGX3.1
#=GS G8Y8V1_PICSO/4-123       AC G8Y8V1.1
#=GS A0A367YPQ4_9ASCO/2-117   AC A0A367YPQ4.1
#=GS W0T9R3_KLUMD/3-132       AC W0T9R3.1
#=GS A0A2V1ANU8_9ASCO/17-112  AC A0A2V1ANU8.1
#=GS A0A421JJA9_9ASCO/1-125   AC A0A421JJA9.1
#=GS G8BX32_TETPH/2-147       AC G8BX32.1
#=GS A0A1E3PNA7_9ASCO/45-181  AC A0A1E3PNA7.1
#=GS A5DPZ9_PICGU/101-202     AC A5DPZ9.2
#=GS A0A367XME6_9ASCO/3-117   AC A0A367XME6.1
#=GS J7SAJ6_KAZNA/3-123       AC J7SAJ6.1
#=GS A0A8J5R6S5_9ASCO/3-125   AC A0A8J5R6S5.1
#=GS A0A2H0ZCE8_CANAR/4-112   AC A0A2H0ZCE8.1
#=GS A0A1X7QWR2_9SACH/2-141   AC A0A1X7QWR2.1
#=GS A0A1G4ME75_LACFM/1-123   AC A0A1G4ME75.1
#=GS Q6BUZ5_DEBHA/6-126       AC Q6BUZ5.2
#=GS A0A4C2EAU6_9SACH/2-121   AC A0A4C2EAU6.1
#=GS A0A512UMU1_9ASCO/3-116   AC A0A512UMU1.1
#=GS G0VHQ3_NAUCC/2-128       AC G0VHQ3.1
#=GS C5M709_CANTT/1-117       AC C5M709.1
#=GS A0A0C7MTM4_9SACH/2-117   AC A0A0C7MTM4.1
#=GS SLD7_ZYGRC/2-121         AC C5DSD6.1
#=GS SLD7_ZYGRC/2-121         DR PDB; 3X37 B; 2-121;
#=GS A0A7H9HZK5_9SACH/2-115   AC A0A7H9HZK5.1
#=GS SLD7_LACTC/1-117         AC C5DJL7.1
#=GS A0A1G4IM72_9SACH/4-124   AC A0A1G4IM72.1
#=GS A0A7H9B5R5_ZYGMR/2-121   AC A0A7H9B5R5.1
#=GS SLD7_EREGS/5-130         AC Q759S0.2
#=GS G8ZP47_TORDE/2-115       AC G8ZP47.1
#=GS SLD7_CANGA/1-132         AC Q6FKM8.1
#=GS SLD7_YEAST/2-125         AC Q08457.1
#=GS G8BDK9_CANPC/8-113       AC G8BDK9.1
#=GS A3GG64_PICST/2-124       AC A3GG64.2
#=GS H2B1I4_KAZAF/2-124       AC H2B1I4.1
#=GS SLD7_KLULA/3-131         AC Q6CJS0.1
#=GS I2GX71_TETBL/1-151       AC I2GX71.1
#=GS Q59ZI8_CANAL/3-123       AC Q59ZI8.1
#=GS A0A4P6XKK2_9ASCO/3-116   AC A0A4P6XKK2.1
#=GS G8JSY5_ERECY/5-138       AC G8JSY5.1
J8PHV2_SACAR/2-125                  ................................................................s-HKLCTLKFILSGK...QGGLVIRDVQLW............GNQLVVNN.PIP.......---EWRGQF..VQYVDLGKLPLWIRSk........dMDT.YRCYSTSATTQAYFKTKL.......KNA.NRAIVLEL..TDKIDQQSQe..........pvYLIIFRE.......NSELYSFRVDLT-m..................................................
SLD7_VANPO/2-142                    .................................................................FEKLAVLKVKLGDR...HSDIVLRDIQLWrkp......ldgDNDNGLDR.SISn....vkEINYLKGEF..LQYIDINKIPLWLRSse......hfSNL.LICFTTSTTTNAFFESKL.......KYI.NRGIVIEV..NSAAAAAAAnny.......qhrYLIFYKN.......GHNVEFIPIDLS-l..................................................
G0WC75_NAUDC/48-175                 .................................................................LKKLKILKIGLGER...HTELKLRDVQLW............IEDNEFHD.NRSalp.qknKVLELNGNF..IQYVDLSKLPFWIRD.........dAQE.NVCFTRSATTLSYFSSKL.......KYK.HRGIVIEI..ISDVPSQE-.............FIVFYRN.......ANTICWFSIDYT-l..................................................
A0A1G4KGX9_9SACH/1-122              .................................................................MSKLLTLTIDVG--...-NGTLIRDVQLW............DMDGEEQR.NGK.......---TYQCKV..MGTIDMKRLPLWVRK..........GKE.YTCFSHSNSTGSYFRSRLa....krRHA.DRAVVLEL..PNEALG-HE.............LAVLYRTis...hgLLSVKCSALDFS-m..................................................
A5DUC8_LODEL/7-161                  asltdgdstfgdiqfwkgscsvsnsdnissnynnekgnknnddknkyknknknknlksndsmpsg--------------...------------............--------.---.......YKGYFKLKA..VSRIKYLSIPVYLVS.........gKSN.FTIFTNNADTEAYFKSQIv....dgKPN.QSSIGDDVglLAKLNS-SK.............YIVFYYS.......MHHVKSFEIDFA-l..................................................
A0A1E5RA54_9ASCO/4-125              ......................................................lqhnrtitlky--------------...SSSIYLRDIQLW............SESASSTS.KPQ......tADSSINYSF..VEYIDLKKLPLFASLstsvrttsrkPPV.STIITSSKQTAYFFIDKL.......ITL.QRCMLIRQ..KTVQN---S.............YLLLFAS.......QD-----------isslqd.............................................
A0A1E5RUL5_HANUV/2-126              ..............................................................elk--------------...--NVILKDINQS............EFEKTVLY.KKKd.....vYDAQNKFKF..LEYVDVRRLPMNLHRy........kQAV.YDVVTTSKVTSHFFLXKL.......VKH.QRHMLVYS..KSC----GK.............YLILYF-.......-------------slpeelrnxsdqvikltdvvdkikmkaldi.....................
A0A8H7GQB4_9ASCO/2-86               ............................................................esdlv--------------...------------............--------.---.......--------F..VSAVNHHKIPLFLVS..........GGP.FDVYTEHQETESYFFHQLv.....rQSE.KTGILAKS..LTE--HADL.............YIVFYVDr....rkGPRVRCYYIDF--cv.................................................
A0A1E4RGX3_9ASCO/3-109              ......................................................ittvvlgapge--------------...----EIRDVQLW............SKGPAPKD.LQD.......------VSW..ISYVNYQMVPVYLIG..........SEN.MMVYSNDDKTNDFFG-KLf.....gYSN.EVGMLFKS..RDE-----E.............YLVFYPDa.....rMMKIRCFIINF--nq.................................................
G8Y8V1_PICSO/4-123                  ...........................................................ldtirl-------------R...YDDYELKDVQVW............CEHTSVDA.NEW.......-WSSQTFIM..ADYIDYRSVPLIFML..........SKP.LHVYSQDGETCSFFKEKLa....dkAVD.NPGMGMLF..RNLANSD-L.............YLAIYVQes...lhTESVRCLPLSL--dl.................................................
A0A367YPQ4_9ASCO/2-117              .......................................................nhigtikihd--------------...STKQVLNDVQLW............SDKETSKL.PNI.......----ASCSS..ISWIKYAEIPLYLTT..........ALP.FAIYSNDPATSDYFRKNLlelplsnNRT.DLGMLCKA..DSD-----T.............YLVFYYE.......DETVKMIVIT---fte................................................
W0T9R3_KLUMD/3-132                  ...............................................................lf--KELVLRLDVG--...-HNTVIRDVQLW............REMDAEKG.HEGg.....pSAKNCLAEV..IGMVSVAKLPLWLDL..........DRR.YRCFTTSETSFRYFNAKLm....rqRHR.NRGILCRI..HSNNDSIE-.............YMLFHKClktdvdaSFEIESIVID---lst................................................
A0A2V1ANU8_9ASCO/17-112             ..................................................gidvrhearlpfrnt--------------...------------............--------.---.......-----SLSH..VAYVNSERIPWFLIS..........QGP.FPVYSSDETTTGYFKEKLa.....rEAL.DRPYIGIL..SKSQDP-QT.............YVVFFIQ.......GNGVRCFCIDFT-t..................................................
A0A421JJA9_9ASCO/1-125              ............................................................mnqvt-------TIRLNSQ...S-GDIIDDIQLW............TDDSVSAK.ELP.......KIIPTSQLFesPRYIKITSIPLYLSF..........GKP.LTVFSSHEDTNIYFKQHLlkfslleNNN.SLGLLVQA..NPN-----I.............YIVFYFEr.....eSEKIMVLILNI--gn.................................................
G8BX32_TETPH/2-147                  .................................................................FNKLAVLKLDLGHR...HNDITLRDIQLW............NKSNLEQQ.HVDkk..sqaKVITMNAKF..LTYVDISCLPIWLINdsn....sshDSE.LYCFTTSNTSLSFFKSKL.......KYN.NRGIVIEI..SKDKNNRNLssrdntnplifsdHIVFYQA.......NNFIQYFYLNID-r..................................................
A0A1E3PNA7_9ASCO/45-181             ...........................................................seqlai--------------...NRSVILEDVQIWstgpgnmlfetpKATEEETE.SNS.......VSKESTLDT..IAFVNPKRVPTWAFS..........SGL.MKVFSSSGATEAYFRQMA.......---.--------..---------.............-------.......-------------ceelekrninttlvgsvstavytiprgllvvtkgvkdtkflllfmelkhti
A5DPZ9_PICGU/101-202                .........................................................ststepas--------------...---QILNDVQLW............GNDNSTFS.GSF.......-------SF..VSYVNVSLIPLYLIS..........GAP.CRVYTTSTITTSFFQNHV.......ASCvGSGTMF--..----VDSQT.............YLVFYSD......tEHNIWGFKIDF--gl.................................................
A0A367XME6_9ASCO/3-117              .......................................................higtikiyds--------------...-TKQVLNDVQLW............SDKETSKL.PNI.......----ASCSS..ISWIKYAEIPLYLTT..........ALP.FAIYSNDPATSDYFRKNLlelplsnNRT.DLGILCKA..DTD-----T.............YFVFYYE.......YETVKMIVIA---fte................................................
J7SAJ6_KAZNA/3-123                  ................................................................l-RDPVVLSFEVSAG...PERVRIRDVQLW............SREAVEAR.SIR.......TQTRCECRF..LGYVSLAKLPLWVWT.........pGEL.YTCHTTSGTTLAYLQAKL.......KRW.DRGIVLQR..VDADNT---.............YWILYRL......dETTVGCTPLNVA-l..................................................
A0A8J5R6S5_9ASCO/3-125              ......................................................lattiqlydsn--------------...----IIDDVQLW............SDTSNFTQ.ELTq....ifTSNLSVHKV..GNYINYTRLPIFLFY..........GHHrLCIYSSNNSTNDYFKNHLvkvsltnPDS.HLGLLFKV..TND-----T.............YLVFYFDf.....eSKTIRAMMLNF--tc.................................................
A0A2H0ZCE8_CANAR/4-112              ......................................ttvtlrheqktvsnidiehesklppki--------------...------------............--------.---.......----GNLEH..VSLVDFEKIPWFLVS..........HGP.FKVFSSDDDTSEFFKTNLaa..vavTEP.HIGILSKS..----QDPQT.............YVVFFFQ.......DMSIRCFCIDFS-t..................................................
A0A1X7QWR2_9SACH/2-141              .................................................................LRQVGVLKFDLGER...HTDIVVKDVQIW............TNNDTLKD.EHQnd...nvSIWSHSGRF..MQYVDLNMLPLWLRPnv.....ssnNST.HICFTTSKATNAYFNSKL.......RDS.RRGIVISF..PSQDTATDSs...........gLWIFYRDedselneDNFVKCFMLDLS-r..................................................
A0A1G4ME75_LACFM/1-123              .................................................................MSKVYILRLDLG--...-NGTKIKDVQVW............DLNADKQQ.KEQ.......---TFDCKI..LGSVDMKRLPLWVEL..........PNE.YVCYSASSTTTSYFRSKLl....qkQYP.DRGLVAEV..LGESATS-E.............YMLFYSEii..dvaRPQIKTSKIDIS-i..................................................
Q6BUZ5_DEBHA/6-126                  ........................................................tisivtdyn--------------...----KVDDIQIW............SNTEGDSK.LGAn.....aLKSNDSFRV..ISYVKCELIPIYLLI..........SKP.LRIYSNNEKTAEFFKKELiq..fsvNYD.HIGLMIKN..ETD---ENL.............FLVLYVEsn...sgDLQIKCIVIDFS-i..................................................
A0A4C2EAU6_9SACH/2-121              .................................................................LEQNAVLKFTLGEK...YDDIIVKDVQLW............SQEPSRPD.GIK.......---QLKGRL..LQYVSMDKLPVWATI.........sGMH.YKVFTWRSSTASYFTSKL.......KNE.NRGIVIDL..LNSYNNSDQ.............LIIFYRK.......LKTVQCLKLNLN-f..................................................
A0A512UMU1_9ASCO/3-116              ..............................................................tak----------LSLQ...TPECLLSDIQIW............SNAELSHP.GSE.......----DRLNL..ISVVNHSKIPLFLVS..........CGP.FDVYSEHHDTEGYFFDTLv.....cSEE.NMGLLAKT..SAE--NSEC.............YVVFYVDr....asAPRVRCYYIDFS-v..................................................
G0VHQ3_NAUCC/2-128                  .................................................................LEKVQVLRIGLGLK...HNGIKLRDVQLW............RDEQTMNN.GNQg.....eKEITLKGEF..ISYIDLRKVPLWLMLpa......tmKEK.NFCFTNSTTTLAYFNSKL.......RYR.HRGIIIEL..ADGNGDDK-.............FIVMYKD.......QNNVRWFCFNIK-l..................................................
C5M709_CANTT/1-117                  ...........................................................mnhitt--------IKIH-E...TSKNVLNDVQLW............SDEETLKL.PNV.......----TSCFS..LSWIRYTALPLHVIT..........SLP.ITIYSNDSATSDYFKKNLlevplsnNKN.EFGILCKA..DTD-----T.............YFVFYYD.......KDAVKMITISF--sd.................................................
A0A0C7MTM4_9SACH/2-117              .........................................kldlddrkvilnlelelknpandg--------------...------------............--------.SHK.......LNSESTARV..AGYIDRAKLPFWVLR..........GAL.YVCLSESSTTAAFFRSKLl....kkRHL.RRGIVASH..EDG------.............HCMFYASpiesdetLFEIHCVELDL--it.................................................
SLD7_ZYGRC/2-121                    .................................................................LEQNAVLKFTLGEK...YDDIIVKDVQLW............SQEPPKAD.GIK.......---QLKGRL..LQYVDMNKLPLWATT.........gSKN.YVVYTWRSSTTSYFASKL.......KNE.NRGIVIDL..LNGTNNNDH.............LLILHRK.......LKKVQCLKLNLN-v..................................................
#=GR SLD7_ZYGRC/2-121         SS    .................................................................-EEEEEEEEE--GG...GTT-EEEEEEEE............ESS---SS.SSE.......---EEEEEE..EEEEEGGGS-GGGGT.........T-EE.EEEE-S-HHHHHHHHHH-.......-ST.TEEEEEEE..-SSSS--SE.............EEEEEEE.......TTEEEEEEEEGG-G..................................................
A0A7H9HZK5_9SACH/2-115              ..............................................................lal---IATLKFNLGSR...YDNIVIRDVQLW............GETGLDGQ.PVR.......---YISGKF..LQYVDLDKLPVWVSC.........sGSL.ATCLTDSGTAIAYFSSKL.......RRE.RRGIVVQA..GDQ------.............FLVLYRD.......RDQVVCLQVDLS-v..................................................
SLD7_LACTC/1-117                    .................................................................MNSECILTLDVG--...-NGVVIQDVQLW............GNSVETQL.PKK.......----GKARV..VAHIDTRKLPLWART..........RGL.FTCFSSSSTTAAYFRAKLl....kdRHA.HRGIVAEL..DKL------.............YLVFFRKeq..spsSFQIECIRLNLA-l..................................................
A0A1G4IM72_9SACH/4-124              .......................................ehglkldvgdgkvflelylerldada--------------...------------............----EGAG.MQS.......KGLARNARV..MSYIDRRKLPLWVRR..........EEC.YACGSESTTTAAYFRSKLm....kqRHV.YRGIVATQ..GSG------.............FCMFFAQqtq.dggVYQIRCVVL----dftl...............................................
A0A7H9B5R5_ZYGMR/2-121              ................................................................f-AKAGVLNFKLGEK...YADTLIRDVQIW............RDVDTAQE.NTK.......-ITTFKGSF..LCYIDMKKLPVWISH..........SSTiSTCLTCSATAKSYFSVKL.......KRL.RRGIVVEL..TEP--LACK.............YVILYRH.......ESRVECLEVELS-v..................................................
SLD7_EREGS/5-130                    ................................................................w-DKWFELRLAVG--...-RGVVLRDVQLW............QRRGSSSS.RPA.......SHTGLTGRL..LQAISLDRLPVWAGR..........SNS.YRCFSSSTTTRAFFAAKLl....rrRHR.ARGLVVEL..APTRAS-KE.............YLIFHKElg..adsHFELCCFTLDLS-r..................................................
G8ZP47_TORDE/2-115                  .................................................................LRQVAVLKFELGSK...NDNVVIRDVQLW............KDVESHEQ.TIR.......---SLKGCF..LQYVDYYKLPLWITG..........IGTvTTCLTGSSTTLAYFTSKL.......RRE.RRGIVIET..TGG------.............YAVLYKS.......ENTVQCLEIDLS-v..................................................
SLD7_CANGA/1-132                    ................................................................m-SLVANLKLSIGSK...NNEFVLRDVQLW............ETSDTSIL.DAGq....lkRVQSYKGRF..VAYVDIKKLPLWIKNq........qSRE.LQCFTRSSTTLRYFSTKL.......GVK.QRGIVFEC..IPLTEKADNqg........ccsYYIFYRN.......ENVVKVVQVDLS-i..................................................
SLD7_YEAST/2-125                    ................................................................s-RKLCTLNFTLSGK...QGSLVIRDIQLW............SNRPTASK.STS.......---ELRGQF..IQYVDLAKLPLWVRSt........nMNT.YRCYSTSATAQAYFKSKL.......RNA.NRGIVIEL..FDKVDQRSQe..........paYLIIFRE.......NTELNCFQVDLT-m..................................................
G8BDK9_CANPC/8-113                  ........................................................ticdadriy--------------...------NDVQFW............SDSDNSMI.IVG.......-----SCEF..ISYIDCNKLPIFLID..........GKS.LSIFSNDPQTEIFFKQKLlqi.tsnADF.RHGLLTKI..GEE-----K.............YVVFYYE.......-TQVRCLVLDFS-k..................................................
A3GG64_PICST/2-124                  .....................................................kklatfvindny--------------...-PSNVLEDVQIW............SGSDTKESdNLS.......SVPTSYERM..PIYVNHRLVPYYLLS..........ARP.LSVFSTSSITSEYFKQTLl....kqAVY.NRDIGILF..KSG--RDET.............YLIFYFDf.....iKKQIMVLIIDFS-r..................................................
H2B1I4_KAZAF/2-124                  .................................................................LDKVAILSFNLGER...RNSITIRDVQLW............KDVADRAT.RGA.......-PKKMKGKF..MQYVDLAKLPIWVKD..........ESE.MLCYSTSSTTVGYFTSKL.......KDE.NRGIVVNI..AKNGNEDPSl...........eFAVIYRD.......VDTIKCFALDTR-r..................................................
SLD7_KLULA/3-131                    .................................................................LEKELILRLNVG--...-HNTVIRDVQLW............REFEDGDG.QIA.......-VKNCLAEV..VGMVNIDKLPFWLNR..........GQR.YQCFTTSETSVNYFRAKLm....rqRHR.NRGIVCKV..TGSQVLTKEq..........feYFLFYKRl.....kTDINASFEIE---smvlhl.............................................
I2GX71_TETBL/1-151                  .................................................................MHKVGVLKFTLGGHsstHNEITLRDVQLWeqk......nnnHESPSEDQ.NLT......ePVHTYKGKF..FQYVSLSRLPNWCFPidny.gnnqdGNQ.SVTFTTSSTTLAYFKSKL.......KTF.DRGIVVEI..SVMDDTRLId..........hlFIIFYSSnkynnskNHNIHWFILDLR-k..................................................
Q59ZI8_CANAL/3-123                  .......................................................ylttiqlyes--------------...-KKNVINDIQLW............STNKTLKL.PTI.......----TSCKP..ISYIKYASLPFYLVY..........CCP.IIVYTDDSDTSDYFKTKLvetpllsN--.--------..---------.............-------.......-------------gksggvggggigllckvdvntflvfyyednvkmlvlkfsk...........
A0A4P6XKK2_9ASCO/3-116              ..........................................................ttslslq--------------...TKTGLLSDIQIW............SDAATSLP.AME.......----SDLFF..VSAVNHHKIPLFLVS..........GGP.FDVYTEHQETESYFFHQLv.....cQSE.KTGVLAKS..LTE--NADL.............YIVFYVDr....rkGPRIRCYYIDF--cv.................................................
G8JSY5_ERECY/5-138                  ................................................................w-GKWAVLEIAVG--...-QGVTVRDVQLW............RESAVTED.SDTsgtmggvEIGLIAGRF..IGSINVEKLPVWVNK..........TGT.YRCYSESWTTCSFFRAKLl....rrRHK.YRGLVVEL..SGRNGAAKE.............YVVFYKQlg..adaQLRVCCSNLDLS-v..................................................
#=GC SS_cons                        .................................................................-EEEEEEEEE--GG...GTT-EEEEEEEE............ESS---SS.SSE.......---EEEEEE..EEEEEGGGS-GGGGT.........T-EE.EEEE-S-HHHHHHHHHH-.......-ST.TEEEEEEE..-SSSS--SE.............EEEEEEE.......TTEEEEEEEEGG-G..................................................
#=GC seq_cons                       ...................................................................................pthhlcDVQLW............pppsstpt.t.t...........hpsch..lsYlchp+LPlalhs..........sps.hpsaosSssTpuYFpsKL.......ppp.pRGllhch..tsp.....t.............YllFYhp.......tpplpshhl-ht.h..................................................
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