#=GF ID Sld7_N
#=GF AC PF18636.2
#=GF DE Mitochondrial morphogenesis protein SLD7 N-terminal domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF07592
#=GF GA 25.00 25.00;
#=GF TC 26.00 25.00;
#=GF NC 24.30 23.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 26249346
#=GF RT The quaternary structure of the eukaryotic DNA replication
#=GF RT proteins Sld7 and Sld3.
#=GF RA Itou H, Shirakihara Y, Araki H;
#=GF RL Acta Crystallogr D Biol Crystallogr. 2015;71:1649-1656.
#=GF DR INTERPRO; IPR041564;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The initiation of eukaryotic chromosomal DNA replication
#=GF CC requires the formation of an active replicative helicase at the
#=GF CC replication origins of chromosomes. Yeast Sld3 and its metazoan
#=GF CC counterpart treslin are the hub proteins mediating protein
#=GF CC associations critical for formation of the helicase. The Sld7
#=GF CC protein interacts with Sld3, and the complex formed is thought
#=GF CC to regulate the function of Sld3. Although Sld7 is a
#=GF CC non-essential DNA replication protein that is found in only a
#=GF CC limited range of yeasts, its depletion slowed the growth of
#=GF CC cells and caused a delay in the S phase. Structure analysis
#=GF CC indicates that the N-terminal domain of Sld7 binds to the
#=GF CC N-terminal region of Sld3 [1].
#=GF SQ 42
#=GS SLD7_VANPO/2-142 AC A7TQ35.1
#=GS A0A1G4KGX9_9SACH/1-122 AC A0A1G4KGX9.1
#=GS A0A1G4KNZ0_9SACH/7-118 AC A0A1G4KNZ0.1
#=GS A0A1E4RGX3_9ASCO/3-109 AC A0A1E4RGX3.1
#=GS S6EJT8_ZYGB2/1-117 AC S6EJT8.1
#=GS A0A1G4ME75_LACFM/1-123 AC A0A1G4ME75.1
#=GS A5DPZ9_PICGU/101-202 AC A5DPZ9.2
#=GS G0VHQ3_NAUCC/2-128 AC G0VHQ3.1
#=GS A0A1E5RA54_9ASCO/5-125 AC A0A1E5RA54.1
#=GS A5DUC8_LODEL/6-161 AC A5DUC8.1
#=GS G0WC75_NAUDC/48-175 AC G0WC75.1
#=GS H2B1I4_KAZAF/2-124 AC H2B1I4.1
#=GS A0A2V1ANU8_9ASCO/19-112 AC A0A2V1ANU8.1
#=GS A3GG64_PICST/2-124 AC A3GG64.2
#=GS SLD7_CANGA/1-132 AC Q6FKM8.1
#=GS G8JSY5_ERECY/5-138 AC G8JSY5.1
#=GS A0A1G4IM72_9SACH/5-124 AC A0A1G4IM72.1
#=GS SLD7_KLULA/3-132 AC Q6CJS0.1
#=GS G8ZP47_TORDC/2-115 AC G8ZP47.1
#=GS A0A448YKZ7_BRENA/25-142 AC A0A448YKZ7.1
#=GS A0A1E3PNA7_9ASCO/45-181 AC A0A1E3PNA7.1
#=GS SLD7_YEAST/2-125 AC Q08457.1
#=GS A0A2H0ZCE8_CANAR/5-112 AC A0A2H0ZCE8.1
#=GS SLD7_LACTC/1-117 AC C5DJL7.1
#=GS A0A1E5RUL5_HANUV/1-126 AC A0A1E5RUL5.1
#=GS J7SAJ6_KAZNA/3-123 AC J7SAJ6.1
#=GS A0A1X7QWR2_9SACH/2-141 AC A0A1X7QWR2.1
#=GS G8BDK9_CANPC/7-113 AC G8BDK9.1
#=GS SLD7_ZYGRC/2-121 AC C5DSD6.1
#=GS SLD7_ZYGRC/2-121 DR PDB; 3X37 B; 2-121;
#=GS A0A120K2Y2_9SACH/5-130 AC A0A120K2Y2.1
#=GS I2GX71_TETBL/1-151 AC I2GX71.1
#=GS Q6BUZ5_DEBHA/6-126 AC Q6BUZ5.2
#=GS A0A0C7MTM4_9SACH/2-117 AC A0A0C7MTM4.1
#=GS Q59ZI8_CANAL/3-123 AC Q59ZI8.1
#=GS A0A367YPQ4_9ASCO/2-117 AC A0A367YPQ4.1
#=GS SLD7_ASHGO/5-130 AC Q759S0.2
#=GS G8Y8V1_PICSO/4-123 AC G8Y8V1.1
#=GS C5M709_CANTT/1-117 AC C5M709.1
#=GS W0T9R3_KLUMD/3-132 AC W0T9R3.1
#=GS A0A367XME6_9ASCO/3-117 AC A0A367XME6.1
#=GS G8BX32_TETPH/2-147 AC G8BX32.1
#=GS A0A421JJA9_9ASCO/1-125 AC A0A421JJA9.1
SLD7_VANPO/2-142 ..................................................................FEKLAVLKVKLGDR...HSDIVLRDIQLWrkp........ldgDNDNGL.DRSISn....vKEI.NY.LKGEFLQYIDINKIPLWLRSse......hfSNL.LICFTTSTTTNAFFESKL.......KYINRGIVIEV..NSAAAAAAAnny.......qhrYLIFYKN.......GHNVEFIPIDLS-l...................................................
A0A1G4KGX9_9SACH/1-122 ..................................................................MSKLLTLTIDVG--...-NGTLIRDVQLW..............DMDGEE.QRNGK......---.-T.YQCKVMGTIDMKRLPLWVRK..........GKE.YTCFSHSNSTGSYFRSRLa....krRHADRAVVLEL..PNEALG-HE.............LAVLYRTis...hgLLSVKCSALDFS-m...................................................
A0A1G4KNZ0_9SACH/7-118 ....................................mrldlgdgstvldldleavstdapeadmgg--------------...------------..............------.-----......---.--.-YAKVVTYIDRRKLPLWVLR..........RSC.YACCSDSSTTAAYFRSKLl....krRHAHRGIMASY..KHS------.............FCMFYAQqs..epqTFQIRCVILD---fsy.................................................
A0A1E4RGX3_9ASCO/3-109 .......................................................ittvvlgapge--------------...----EIRDVQLW..............SKGPAP.KDLQD......---.--.--VSWISYVNYQMVPVYLIG..........SEN.MMVYSNDDKTNDFFG-KLf.....gYSNEVGMLFKS..RDE-----E.............YLVFYPDa.....rMMKIRCFIINF--nq..................................................
S6EJT8_ZYGB2/1-117 ..................................................................MEQVAVLKFTLGDR...CEDICIKDVQLW..............ASEP-R.QNEVG......--V.KS.LKGRFVQYVDLGKLPLWTTK..........HNAsWTCYTVRSSTLGYFASKL.......KHNRRGIVVEL..VPGGE----.............LLVLHRR.......GSEVHCLRLTN--ei..................................................
A0A1G4ME75_LACFM/1-123 ..................................................................MSKVYILRLDLG--...-NGTKIKDVQVW..............DLNADK.QQKEQ......---.-T.FDCKILGSVDMKRLPLWVEL..........PNE.YVCYSASSTTTSYFRSKLl....qkQYPDRGLVAEV..LGESATSE-.............YMLFYSEii..dvaRPQIKTSKIDIS-i...................................................
A5DPZ9_PICGU/101-202 ..........................................................ststepas--------------...---QILNDVQLW..............GNDNST.FSGS-......---.--.--FSFVSYVNVSLIPLYLIS..........GAP.CRVYTTSTITTSFFQNHV.......ASC-----VGS..GTMFVDSQT.............YLVFYSD......tEHNIWGFKID---fgl.................................................
G0VHQ3_NAUCC/2-128 ..................................................................LEKVQVLRIGLGLK...HNGIKLRDVQLW..............RDEQTM.NNGNQ.....gEKE.IT.LKGEFISYIDLRKVPLWLMLpa......tmKEK.NFCFTNSTTTLAYFNSKL.......RYRHRGIIIEL..ADGNGDDK-.............FIVMYKD.......QNNVRWFCFNIK-l...................................................
A0A1E5RA54_9ASCO/5-125 ........................................................qhnrtitlky--------------...SSSIYLRDIQLW..............SESASS.TSKPQ......TAD.SS.INYSFVEYIDLKKLPLFASLstsvrttsrkP-PvSTIITSSKQTAYFFIDKL.......ITLQRCMLIRQ..KTVQN---S.............YLLLFAS.......QD-----------isslqd..............................................
A5DUC8_LODEL/6-161 tasltdgdstfgdiqfwkgscsvsnsdnissnynnekgnknnddknkyknknknknlksndsmpsg--------------...------------..............------.-----......-YK.GY.FKLKAVSRIKYLSIPVYLVS.........gKSN.FTIFTNNADTEAYFKSQIv....dgKPNQSSIGDDVglLAKLNS-SK.............YIVFYYS.......MHHVKSFEIDFA-l...................................................
G0WC75_NAUDC/48-175 ..................................................................LKKLKILKIGLGER...HTELKLRDVQLW..............IEDNEF.HDNRSal.pqkNKV.LE.LNGNFIQYVDLSKLPFWIRD..........DAQeNVCFTRSATTLSYFSSKL.......KYKHRGIVIEI..ISDVPSQE-.............FIVFYRN.......ANTICWFSIDYT-l...................................................
H2B1I4_KAZAF/2-124 ..................................................................LDKVAILSFNLGER...RNSITIRDVQLW..............KDVADR.ATRGA......--P.KK.MKGKFMQYVDLAKLPIWVKD..........ESE.MLCYSTSSTTVGYFTSKL.......KDENRGIVVNI..AKNGNEDPSl...........eFAVIYRD.......VDTIKCFALDTR-r...................................................
A0A2V1ANU8_9ASCO/19-112 ....................................................dvrhearlpfrnts--------------...------------..............------.-----......---.--.--LSHVAYVNSERIPWFLIS..........QGP.FPVYSSDETTTGYFKEKLa.....rEALDRPYIGIL..SKSQD-PQT.............YVVFFIQ.......GNGVRCFCIDF--tt..................................................
A3GG64_PICST/2-124 ..........................................................kklatfvi-----------NDN...YPSNVLEDVQIW..............SGSDTK.ESDNL......SSV.PT.SYERMPIYVNHRLVPYYLLS..........ARP.LSVFSTSSITSEYFKQTLl....kqAVYNRDIGILF..KSG--RDET.............YLIFYFDf.....iKKQIMVLIIDFS-r...................................................
SLD7_CANGA/1-132 .................................................................m-SLVANLKLSIGSK...NNEFVLRDVQLW..............ETSDTS.ILDAGq....lKRV.QS.YKGRFVAYVDIKKLPLWIKNq........qSRE.LQCFTRSSTTLRYFSTKL.......GVKQRGIVFEC..IPLTEKADNqg........ccsYYIFYRN.......ENVVKVVQVDLS-i...................................................
G8JSY5_ERECY/5-138 .................................................................w-GKWAVLEIAVG--...-QGVTVRDVQLW..............RESAVT.EDSDTsgtmggVEI.GL.IAGRFIGSINVEKLPVWVNK..........TGT.YRCYSESWTTCSFFRAKLl....rrRHKYRGLVVEL..SGRNGAAKE.............YVVFYKQlg..adaQLRVCCSNLDLS-v...................................................
A0A1G4IM72_9SACH/5-124 .....................................hglkldvgdgkvflelylerldadaegag--------------...------------..............------.---MQ......SKG.LA.RNARVMSYIDRRKLPLWVRR..........EEC.YACGSESTTTAAYFRSKLm....kqRHVYRGIVATQ..GSG------.............FCMFFAQ.......-------------qtqdggvyqircvvldftl.................................
SLD7_KLULA/3-132 ..................................................................LEKELILRLNVG--...-HNTVIRDVQLW..............REFEDG.DGQIA......--V.KN.CLAEVVGMVNIDKLPFWLNR..........GQR.YQCFTTSETSVNYFRAKLm....rqRHRNRGIVCKV..TGSQVLTKEq..........feYFLFYKRl.....kTDINASFE-----iesmvlhls...........................................
G8ZP47_TORDC/2-115 ..................................................................LRQVAVLKFELGSK...NDNVVIRDVQLW..............KDVESH.EQTIR......---.-S.LKGCFLQYVDYYKLPLWITG..........IGTvTTCLTGSSTTLAYFTSKL.......RRERRGIVIET..TGG------.............YAVLYKS.......ENTVQCLEIDLS-v...................................................
A0A448YKZ7_BRENA/25-142 ..............................................................slda--------------...-----LSDVRFY..............KRDLAD.QANSSa...leKLL.LD.SELKLVNLVDLDNIPFWLFDr.......svSSD.YLVYTTDPSTEGFFSAVLqa..siiSSKSATLLLET..VKSVREGR-.............YVLVYPV.......INSEERVEIN---tal.................................................
A0A1E3PNA7_9ASCO/45-181 ...........................................................seqlain--------------...-RSVILEDVQIWstgpgnmlfetpkaTE---E.ETESN......SVS.KE.STLDTIAFVNPKRVPTWAFS..........SGL.MKVFSSSGATEAYFRQM-.......-----------..---------.............-------.......-------------aceelekrninttlvgsvstavytiprgllvvtkgvkdtkflllfmelkhti
SLD7_YEAST/2-125 .................................................................s-RKLCTLNFTLSGK...QGSLVIRDIQLW..............SNRPTA.SKSTS......---.-E.LRGQFIQYVDLAKLPLWVRSt........nMNT.YRCYSTSATAQAYFKSKL.......RNANRGIVIEL..FDKVDQRSQe..........paYLIIFRE.......NTELNCFQVDLT-m...................................................
A0A2H0ZCE8_CANAR/5-112 .......................................tvtlrheqktvsnidiehesklppkig--------------...------------..............------.-----......---.--.-NLEHVSLVDFEKIPWFLVS..........HGP.FKVFSSDDDTSEFFKTNLaa..vavTEPHIGIL---..-SKSQDPQT.............YVVFFFQ.......DMSIRCFCIDFS-t...................................................
SLD7_LACTC/1-117 ..................................................................MNSECILTLDVG--...-NGVVIQDVQLW..............GNSVET.QLPKK......---.--.GKARVVAHIDTRKLPLWART..........RGL.FTCFSSSSTTAAYFRAKLl....kdRHAHRGIVAEL..DKL------.............YLVFFRKeq..spsSFQIECIRLNLA-l...................................................
A0A1E5RUL5_HANUV/1-126 ...............................................................mel--------------...-KNVILKDINQS..............EFEKTVlYKKKD......VYD.AQ.NKFKFLEYVDVRRLPMNLHRy........kQAV.YDVVTTSKVTSHFFLXKL.......VKHQRHMLVYS..KSCG----K.............YLILYF-.......-------------slpeelrnxsdqvikltdvvdkikmkaldi......................
J7SAJ6_KAZNA/3-123 .................................................................l-RDPVVLSFEVSAG...PERVRIRDVQLW..............SREAVE.ARSIR......-TQ.TR.CECRFLGYVSLAKLPLWVWT.........pGEL.YTCHTTSGTTLAYLQAKL.......KRWDRGIVLQR..VDADNT---.............YWILYRL......dETTVGCTPLNVA-l...................................................
A0A1X7QWR2_9SACH/2-141 ..................................................................LRQVGVLKFDLGER...HTDIVVKDVQIW..............TNNDTL.KDEHQn...dnVSI.WS.HSGRFMQYVDLNMLPLWLRPnv.....ssnNST.HICFTTSKATNAYFNSKL.......RDSRRGIVISF..PSQDTATDSs...........gLWIFYRDedselneDNFVKCFMLDLS-r...................................................
G8BDK9_CANPC/7-113 .........................................................tticdadri--------------...-----YNDVQFW..............SDSDNS.MIIVG......---.--.-SCEFISYIDCNKLPIFLID..........GKS.LSIFSNDPQTEIFFKQKLlqi.tsnADFRHGLLTKI..GEE-----K.............YVVFYYE.......-TQVRCLVLDFS-k...................................................
SLD7_ZYGRC/2-121 ..................................................................LEQNAVLKFTLGEK...YDDIIVKDVQLW..............SQEPPK.ADGIK......---.-Q.LKGRLLQYVDMNKLPLWATT..........GSKnYVVYTWRSSTTSYFASKL.......KNENRGIVIDL..LNGTNNNDH.............LLILHRK.......LKKVQCLKLNLN-v...................................................
#=GR SLD7_ZYGRC/2-121 SS ..................................................................-EEEEEEEEE--GG...GTT-EEEEEEEE..............ESS---.SSSSE......---.-E.EEEEEEEEEEGGGS-GGGGT..........T-EEEEEE-S-HHHHHHHHHH-.......-STTEEEEEEE..-SSSS--SE.............EEEEEEE.......TTEEEEEEEEGG-G...................................................
A0A120K2Y2_9SACH/5-130 ................................................................lv--QKYILTLDVG--...-HEIVLRDVQLW..............EKCPDG.SPVPD......-KV.VK.TSAVLIGSIDINKLPFWIGK..........THQ.GRCYSNSSTTSAFFRSKLm....rkRRESRALLIEV..SAVGT-SKE.............YLIFYIHpr..dqkTANVAYFELDLA-l...................................................
I2GX71_TETBL/1-151 ..................................................................MHKVGVLKFTLGGHsstHNEITLRDVQLWeqk........nnnHESPSE.DQNLT......EPV.HT.YKGKFFQYVSLSRLPNWCFPidny.gnnqdGNQ.SVTFTTSSTTLAYFKSKL.......KTFDRGIVVEI..SVMDDTRLId..........hlFIIFYSSnkynnskNHNIHWFILDLR-k...................................................
Q6BUZ5_DEBHA/6-126 .........................................................tisivtdyn--------------...----KVDDIQIW..............SNTEGD.SKLGA......NAL.KSnDSFRVISYVKCELIPIYLLI..........SKP.LRIYSNNEKTAEFFKKELiq..fsvNYDHIGLMIKN..ETD---ENL.............FLVLYVEsn...sgDLQIKCIVIDFS-i...................................................
A0A0C7MTM4_9SACH/2-117 ........................................kldlddrkvilnlelelknpandgsh--------------...------------..............------.-----......KLN.SE.STARVAGYIDRAKLPFWVLR..........GAL.YVCLSESSTTAAFFRSKLl....kkRHLRRGIVASH..EDG------.............HCMFYASpiesdetLFEIHCVELDL--it..................................................
Q59ZI8_CANAL/3-123 ........................................................ylttiqlyes--------------...-KKNVINDIQLW..............STNKTL.KLPTI......---.--.TSCKPISYIKYASLPFYLVY..........CCP.IIVYTDDSDTSDYFKTKLvet.pllS----------..---------.............-------.......-------------ngksggvggggigllckvdvntflvfyyednvkmlvlkfsk...........
A0A367YPQ4_9ASCO/2-117 ........................................................nhigtikihd--------------...STKQVLNDVQLW..............SDKETS.KLPNI......---.--.ASCSSISWIKYAEIPLYLTT..........ALP.FAIYSNDPATSDYFRKNLle...lpLSNNRTDLGML..CKAD--SDT.............YLVFYYE.......DETVKMIVIT---fte.................................................
SLD7_ASHGO/5-130 .................................................................w-DKWFELRLAVG--...-RGVVLRDVQLW..............QRRGSS.SSRPA......-SH.TG.LTGRLLQAISLDRLPVWAGR..........SNS.YRCFSSSTTTRAFFAAKLl....rrRHRARGLVVEL..APTRAS-KE.............YLIFHKElg..adsHFELCCFTLDLS-r...................................................
G8Y8V1_PICSO/4-123 ............................................................ldtirl-------------R...YDDYELKDVQVW..............CEHTSV.DANEW......--W.SS.QTFIMADYIDYRSVPLIFML..........SKP.LHVYSQDGETCSFFKEKLa....dkAVDNPGMGMLF..RNLANS-DL.............YLAIYVQes...lhTESVRCLPLSL--dl..................................................
C5M709_CANTT/1-117 ...........................................................mnhitti---------KIH-E...TSKNVLNDVQLW..............SDEETL.KLPNV......---.--.TSCFSLSWIRYTALPLHVIT..........SLP.ITIYSNDSATSDYFKKNLlevplsnNKNEFGILCKA..DTD-----T.............YFVFYYD.......KDAVKMITIS---fsd.................................................
W0T9R3_KLUMD/3-132 ................................................................lf--KELVLRLDVG--...-HNTVIRDVQLW..............REMDAE.KGHEG.....gPSA.KN.CLAEVIGMVSVAKLPLWLDL..........DRR.YRCFTTSETSFRYFNAKLm....rqRHRNRGILCRI..HSNNDSI-E.............YMLFHKClktdvdaSFEIESI------vidlst..............................................
A0A367XME6_9ASCO/3-117 .......................................................higtikiydst--------------...--KQVLNDVQLW..............SDKETS.KLPNI......---.--.ASCSSISWIKYAEIPLYLTT..........ALP.FAIYSNDPATSDYFRKNLlelplsnNRTDLGILCKA..DTD-----T.............YFVFYYE.......YETVKMIVIA---fte.................................................
G8BX32_TETPH/2-147 ..................................................................FNKLAVLKLDLGHR...HNDITLRDIQLW..............NKSNLE.QQHVDkk..sqAKV.IT.MNAKFLTYVDISCLPIWLINdsn....sshDSE.LYCFTTSNTSLSFFKSKL.......KYNNRGIVIEI..SKDKNNRNLssrdntnplifsdHIVFYQA.......NNFIQYFYLNID-r...................................................
A0A421JJA9_9ASCO/1-125 ...............................................................mnq-----VTTIRLNSQ...SGD-IIDDIQLW..............TDDSVS.AKELP......KIIpTS.QLFESPRYIKITSIPLYLSF..........GKP.LTVFSSHEDTNIYFKQHLlkfslleNNNSLGLLVQA..NPN-----I.............YIVFYFEr.....eSEKIMVLILNI--gn..................................................
#=GC SS_cons ..................................................................-EEEEEEEEE--GG...GTT-EEEEEEEE..............ESS---.SSSSE......---.-E.EEEEEEEEEEGGGS-GGGGT..........T-EEEEEE-S-HHHHHHHHHH-.......-STTEEEEEEE..-SSSS--SE.............EEEEEEE.......TTEEEEEEEEGG-G...................................................
#=GC seq_cons ....................................................................................pt.hlcDVQLW..............ppptst.ptt.t...........p.hpschlsYlchp+LPlWlhp..........sp..htsaosSssTsuYFcsKL.......pptpRGllhch..tss...................YllFYhp.......tpplpsh.lsh..h...................................................
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