#=GF ID SpvD
#=GF AC PF05563.16
#=GF DE Salmonella plasmid virulence protein SpvD
#=GF PI Sal_SpvD;
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF SE Pfam-B_7864 (release 8.0)
#=GF GA 25.00 25.00;
#=GF TC 498.90 498.70;
#=GF NC 23.10 18.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 11570190
#=GF RT Sequence polymorphism of the Salmonella plasmid virulence factor
#=GF RT D (SpvD) in Salmonella enterica isolates of animal origin.
#=GF RA Bauerfeind R, Barth S, Weiss R, Baljer G;
#=GF RL Berl Munch Tierarztl Wochenschr 2001;114:404-408.
#=GF RN [2]
#=GF RM 27789710
#=GF RT The Salmonella Effector SpvD Is a Cysteine Hydrolase with a
#=GF RT Serovar-specific Polymorphism Influencing Catalytic Activity,
#=GF RT Suppression of Immune Responses, and Bacterial Virulence.
#=GF RA Grabe GJ, Zhang Y, Przydacz M, Rolhion N, Yang Y, Pruneda JN,
#=GF RA Komander D, Holden DW, Hare SA;
#=GF RL J Biol Chem. 2016;291:25853-25863.
#=GF DR INTERPRO; IPR008834;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family consists of several SpvD plasmid virulence proteins
#=GF CC from different Salmonella species [1].The structure of the
#=GF CC protein from Salmonella typhimurium has been solved and shows a
#=GF CC papain-like fold, with a predicted catalytic triad of Cys73,
#=GF CC His162 and Asp182. The protein has been shown to have
#=GF CC deubiquitinating-like activity, releasing aminoluciferin (AML)
#=GF CC from Ub-AML [2].
#=GF SQ 1
#=GS VSDE_SALTY/1-212 AC P0A2N2.1
VSDE_SALTY/1-212 MRVSGSASSQDIISRINSKNINNNDSNEVKRIKDALCIESKERILYPQNLSRDNLKQMARYVNNTYVHYSGNCVLLSACLHYNIHHRQDILSSKNTASPTVGLDSAIVDKIIFGHELNQSYCLNSIDEVEKEILNRYDIKRESSFIISAENYIAPIIGECRHDFNAVVICEYDKKPYVQFIDSWKTSNILPSLQEIKKHFSSSGEFYVRAYD
#=GC seq_cons MRVSGSASSQDIISRINSKNINNNDSNEVKRIKDALCIESKERILYPQNLSRDNLKQMARYVNNTYVHYSGNCVLLSACLHYNIHHRQDILSSKNTASPTVGLDSAIVDKIIFGHELNQSYCLNSIDEVEKEILNRYDIKRESSFIISAENYIAPIIGECRHDFNAVVICEYDKKPYVQFIDSWKTSNILPSLQEIKKHFSSSGEFYVRAYD
//
