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Database: Pfam
Entry: Stn1_C
LinkDB: Stn1_C
Original site: Stn1_C 
#=GF ID   Stn1_C
#=GF AC   PF12659.8
#=GF DE   Telomere capping C-terminal wHTH
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Wood V
#=GF GA   25.00 25.00;
#=GF TC   70.40 69.10;
#=GF NC   24.20 24.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   17715303
#=GF RT   Protection of telomeres by a conserved Stn1-Ten1 complex. 
#=GF RA   Martin V, Du LL, Rozenzhak S, Russell P; 
#=GF RL   Proc Natl Acad Sci U S A. 2007;104:14038-14043.
#=GF RN   [2]
#=GF RM   17293872
#=GF RT   RPA-like proteins mediate yeast telomere function. 
#=GF RA   Gao H, Cervantes RB, Mandell EK, Otero JH, Lundblad V; 
#=GF RL   Nat Struct Mol Biol. 2007;14:208-214.
#=GF RN   [3]
#=GF RM   19884503
#=GF RT   Telomere capping proteins are structurally related to RPA with
#=GF RT   an additional telomere-specific domain.
#=GF RA   Gelinas AD, Paschini M, Reyes FE, Heroux A, Batey RT, Lundblad
#=GF RA   V, Wuttke DS;
#=GF RL   Proc Natl Acad Sci U S A. 2009; [Epub ahead of print]
#=GF DR   INTERPRO; IPR024263;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain consists of tandem winged helix-turn-helix motifs.
#=GF CC   Stn1 and Ten1 are DNA-binding proteins with specificity for
#=GF CC   telomeric DNA substrates and both protect chromosome termini
#=GF CC   from unregulated resection and regulate telomere length. Stn1
#=GF CC   complexes with Ten1 and Cdc13 to function as a telomere-specific
#=GF CC   replication protein A (RPA)-like complex [1]. These three
#=GF CC   interacting proteins associate with the telomeric overhang in
#=GF CC   budding yeast, whereas a single protein known as Pot1
#=GF CC   (protection of telomeres-1) performs this function in fission
#=GF CC   yeast, and a two-subunit complex consisting of POT1 and TPP1
#=GF CC   associates with telomeric ssDNA in humans. S.pombe has Stn1- and
#=GF CC   Ten1-like proteins that are essential for chromosome end
#=GF CC   protection. Stn1 orthologues exist in all species that have
#=GF CC   Pot1, whereas Ten1-like proteins can be found in all fungi.
#=GF CC   Fission yeast Stn1 and Ten1 localise at telomeres in a manner
#=GF CC   that correlates with the length of the ssDNA overhang,
#=GF CC   suggesting that they specifically associate with the telomeric
#=GF CC   ssDNA. Two separate protein complexes are required for
#=GF CC   chromosome end protection in fission yeast. Protection of
#=GF CC   telomeres by multiple proteins with OB-fold domains is conserved
#=GF CC   in eukaryotic evolution [2].
#=GF SQ   23
#=GS A0A0C7N971_9SACH/341-461  AC A0A0C7N971.1
#=GS A0A1G4INE3_9SACH/405-527  AC A0A1G4INE3.1
#=GS G0VA11_NAUCC/355-474      AC G0VA11.1
#=GS S6ENV7_ZYGB2/298-415      AC S6ENV7.1
#=GS A0A1G4K704_9SACH/374-495  AC A0A1G4K704.1
#=GS C5DRU2_ZYGRC/286-405      AC C5DRU2.1
#=GS Q6CTL1_KLULA/318-432      AC Q6CTL1.1
#=GS I6NDY0_ERECY/404-522      AC I6NDY0.1
#=GS G8ZLI6_TORDC/349-467      AC G8ZLI6.1
#=GS W0TFA4_KLUMD/293-403      AC W0TFA4.1
#=GS STN1_YEAST/363-490        AC P38960.1
#=GS STN1_YEAST/363-490        DR PDB; 3K10 A; 363-490;
#=GS STN1_YEAST/363-490        DR PDB; 3KEY A; 363-490;
#=GS A7TGZ8_VANPO/312-430      AC A7TGZ8.1
#=GS C5E2R6_LACTC/334-455      AC C5E2R6.1
#=GS A0A1G4MK88_LACFM/356-475  AC A0A1G4MK88.1
#=GS A0A0X8HVM6_9SACH/337-455  AC A0A0X8HVM6.1
#=GS G8BN07_TETPH/416-535      AC G8BN07.1
#=GS Q74ZP7_ASHGO/313-432      AC Q74ZP7.1
#=GS Q6FM89_CANGA/316-426      AC Q6FM89.1
#=GS J4TSL8_SACK1/363-490      AC J4TSL8.1
#=GS H2AMU0_KAZAF/238-353      AC H2AMU0.1
#=GS J7RPP1_KAZNA/317-438      AC J7RPP1.1
#=GS A0A1X7R6S3_9SACH/343-461  AC A0A1X7R6S3.1
#=GS G0W3X3_NAUDC/401-520      AC G0W3X3.1
A0A0C7N971_9SACH/341-461             .....qqe---DEEASRVFAQAVARLADMGVARVLA.QGRILNLQMLQFCYTQASARIAVLVAMRLNTGVLDFEALCNSVNLL.yQKP.lNGILLDIYKRALRCATEN.PNSLVRSWWIEMSSSSTAV.......VHF---vr
A0A1G4INE3_9SACH/405-527             .......c-PIEELTSTIFRQALETLADWGLIRFFA.QGRILNLATIKKLATSVSQRLSALVTLRLNTGKFEFTKLCYSVHVE.yQSP.mNAIFMAILKRELRKMVQRpNQTLLTSWWIEVITVNSVV.......VHFEY-a.
G0VA11_NAUCC/355-474                 ........KTVEEIKAGIFYDYLERLTKMGLITIST.HGNLIDLKSLKQLSRYCQRRLSTLIRLQSLCINVDYNFIRQKLKIS..NLT..KLAIISIYKETIKVFIKA.SPSLLKSWWIDLKNDTIAL.......IHLEYS..
S6ENV7_ZYGB2/298-415                 ........KPWEQLRTEVFNDMLGKLEQAGLVYFP-.NVHVLDWISLKNLHNYSVERTWTLLKLQCNVGVLDHDYIRKKLSKP..ELT..GKAILDVFKETLRAICEA.YPNFLASWWIDTDKNSSV-.......IHFVY-p.
A0A1G4K704_9SACH/374-495             .......r-SVEEEASFYFTQVLERYVNVGLIGIFA.QGRILNLKTIKACDKYVAQRVAALVALGMNTGKIDFRKTADDLRIAcnKSS..SQILLALHKRALQKIVET.GDTNLAAWWLELINNRCAI.......IRFEY-a.
C5DRU2_ZYGRC/286-405                 ........KPWQQLKSESLYDQLHKLQKSGLLRCHS.NDNLVDLKPLKDLHEYSMHRVLTLIKLQCNTGRIDYNHIRDKLKHC..EFT..KKAIVDIFKESLRRICLL.YPQLLVGWWIGADGGEFSV.......IHFKY-e.
Q6CTL1_KLULA/318-432                 ........KTEPVLHLKFYETFLAQLAEMAIITL--.DSFTINMTNLHNCYRYIITRFQSLINVQIPQITIKYSEIRNFCKLP..LLS..KKLILQMCKHFLNTT---.HIGNLIDWWVDPTSEERYK.......VFFTYS..
I6NDY0_ERECY/404-522                 .....sig----GIKQKLYADVIANFASMGVISVI-.-NQQYIIPAIGSLKQYINSRFETWTKLEIISGKIIYKQVREISGLT..QMT..TMFIIMLVKVLLRKYLSK.MVTSVDNWYLDAKSEVQGYi.....iVRFYY-t.
G8ZLI6_TORDC/349-467                 ........KSLEQLKTETFFRLIDYLVTSGLLKYV-.NRNVIDLMPLKSLYAYCTKRLRALIKMQCYLGTIEVKIIRQKLSLP..SLS..QKAIIDTFKEALRVAAYG.HPNLFTGWWIEINSEKESA.......IHLEY-k.
W0TFA4_KLUMD/293-403                 .....lva-------SASLQHYLNQLEDSEIVSQ--.DDGVLELKNLQHCYRYIMFRFQSLINVQIPHIKIKYEQIKQFCNLH..KLP..NKLILDICKYFFNNT---.HIGNLINWWIEPVSEQSFQ.......VHFTY-a.
STN1_YEAST/363-490                   ........KSFDSLEKEAFRDLVNRLVSQGLIGLKDkTSETFDLLPLKNLFEYAEKRISVLMKLQCYTGTVQLSHVQEKLHLP..YIT..TNGIVDVFKECLKRTKKQ.YPEVLKNWWIDLDPKNGMEdqnsgilLHLEY-a.
#=GR STN1_YEAST/363-490        SS    ........--HHHHHHHHHHHHHHHHHCTTSSEEEETTTTEEE-HHHHHHHHHHHHHHHHHHHCT-SEEEEEHHHHHHHCT-T..T--..HHHHHHHHHHHHHHHHHH.-TTTEEEEEEEE-----------EEEEEEEE--.
A7TGZ8_VANPO/312-430                 ........KGLEDIKIEVFYKLLKTFSKNGLIKYI-.DETEIDLSLLHKIYKNFQRQVSVLILLRCTTGNIDLTKLKQLPDIN..SSS..NIEFADILQESIEKIAKS.SPNLLKIWRIKKIDKNNYK.......LNFVYH..
C5E2R6_LACTC/334-455                 .......r-PVDEVASSLFADVLQRLARAGLISVFA.QGRILNLRVLKNCDDYVTQRIAALVELRSYTGKIDFRRACDLLGLA..RSAplERLLVDLHKRALRRLAAA.SDTPLQSWWIELAGPAAAF.......VHFEYH..
A0A1G4MK88_LACFM/356-475             ......ea--LEDVKMMLFNEVLQRLASMELISLFE.RQKLINIKNLKSCFNYISERISTVVKLGCYTGKIDYRHIRDALGYR..NLT..NYVILELYKEALRHFFAS.THQSNVRWWIDLNNEEVSF.......IHFEY-g.
A0A0X8HVM6_9SACH/337-455             ........KTIKEIKMELYDTSIVYFESMGIIGIA-.GEQKHLIVKLKKLKEFITSRIGTWTKLQLASGKVFYKHVRDRSGLG..NLT..KKFILMLVKAILRHYLSK.SNVKISDWFMETPAPEYIL.......LRLNY-n.
G8BN07_TETPH/416-535                 .....nkf---SHYEFTLLKEYLVDLQKIELIRVNN.AGDTMDLNNLHRLFSYCHKHCKLFINLKYNTVTINHSLIKKKLDIH..KVP..DMVIINIYRESIKNFVNQ.NPRLLKSWFIEVNANRSSI.......LYLKY-p.
Q74ZP7_ASHGO/313-432                 .......a-GLEKTKALLYDSVLAQFCTMGVLSLE-.GSDQIQLHLL-PVKEHIVARIDTWLKLHVRAGKLLYHQVRSTCGLP..QMS..APFIVNLTKVLLRQHISQ.RTELVDSWFLDAKSEERGYl.....lVRFNY-i.
Q6FM89_CANGA/316-426                 .......i-SNDDMQI-ILQEYLSQLITGDVLVIT-.ARNRVSLKKLHALKAYTQKRINLLLKIQALLGTVRYQDVLQSTSMA..-IP..AETIIDAFKESLRTIDAG.-----VAWFIETHQHSFT-.......IHFTYS..
J4TSL8_SACK1/363-490                 ........KSLDTCENETFQNLVDGLANLGLIELRGvASKVLDLLPLRKLFDYAQKRILVLVKLQCYTGTIELHHVQEKLHLP..CIT..INGIISVFKEGLKQTANQ.YPQVLKKWWIDLNSKNGSEdqrngflLHLEY-v.
H2AMU0_KAZAF/238-353                 rsvqpwdp--------AQFILILEKLIALKLIQFN-.--NILLLQPLFDLNTYCNTKIRTIINLKCNLLTIDINFIKNNLNLD.kSMS..HLTIIEIFKINLKLIMKD.--SPIKKWWIDLKDENLSL.......IHLEF-i.
J7RPP1_KAZNA/317-438                 .......y-SQDQLISMIFINELNHLQALHLIRIED.HNNQIMAKPLQNLYHYARGKIRLWIKLRTGVGIVNNVQIIDRLTLD.rEIS..SNVIALVFKLVMDDTVSTlSQNFIRSWFIETKNDNTSW.......VHISY-t.
A0A1X7R6S3_9SACH/343-461             ......pt------KEKYFCTFLTKLENEALISRKKrKQNIINVELLQKLYNYSSQRLKAMITIKCLTITVDTSFVLDKLELNhgSIS..TIIIITIFKIALSRIVSD.KSNHIIDWWIEKRTDAFWL.......IHLKY-d.
G0W3X3_NAUDC/401-520                 ........KSFEEIKSEQFINYIKSLVASTVVELTS.NDNVIDLSILKKVSKYCNERLNISIKLQNLSISIDYKYIKQKLSLK..QFK..NMMIIEIFKENIKIFTMN.TSSIIKNWYIDLKNEKIAI.......VYLEY-y.
#=GC SS_cons                         ........--HHHHHHHHHHHHHHHHHCTTSSEEEETTTTEEE-HHHHHHHHHHHHHHHHHHHCT-SEEEEEHHHHHHHCT-T..T--..HHHHHHHHHHHHHHHHHH.-TTTEEEEEEEE-----------EEEEEEEE--.
#=GC seq_cons                        .........sh-plcpphFtphLspLsshGLIplh..pspllsLpsL+pLhpYsppRlpsLlcLpshoGpl-appl+ppLsLs..pho..sthIlslaKcsL+phspp.psshlpsWWI-hpscptuh.......lHhpY...
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