GenomeNet

Database: Pfam
Entry: Sun2_CC2
LinkDB: Sun2_CC2
Original site: Sun2_CC2 
#=GF ID   Sun2_CC2
#=GF AC   PF18580.1
#=GF DE   SUN2 coiled coil domain 2
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF07923
#=GF GA   28.50 28.50;
#=GF TC   28.50 29.10;
#=GF NC   27.80 28.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Coiled-coil
#=GF RN   [1]
#=GF RM   26688217
#=GF RT   Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic
#=GF RT   Regulators.
#=GF RA   Nie S, Ke H, Gao F, Ren J, Wang M, Huo L, Gong W, Feng W;
#=GF RL   Structure. 2016;24:80-91.
#=GF RN   [2]
#=GF RM   22170055
#=GF RT   Structure of Sad1-UNC84 homology (SUN) domain defines features
#=GF RT   of molecular bridge in nuclear envelope.
#=GF RA   Zhou Z, Du X, Cai Z, Song X, Zhang H, Mizuno T, Suzuki E, Yee
#=GF RA   MR, Berezov A, Murali R, Wu SL, Karger BL, Greene MI, Wang Q;
#=GF RL   J Biol Chem. 2012;287:5317-5326.
#=GF DR   SO; 0001080; coiled_coil;
#=GF CC   LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1,
#=GF CC   and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins
#=GF CC   from the inner and outer nuclear membranes (INM and ONM,
#=GF CC   respectively). the formation of LINC complexes by KASH and SUN
#=GF CC   proteins at the nuclear envelope (NE) establishes the physical
#=GF CC   linkage between the cytoskeleton and nuclear lamina, which is
#=GF CC   instrumental for the mechanical force transmission from the
#=GF CC   cytoplasm to the nuclear interior, and is essential for cellular
#=GF CC   processes such as nuclear positioning and migration,
#=GF CC   centrosome-nucleus anchorage, and chromosome dynamics. SUN2
#=GF CC   possesses two coiled-coil domains (CC1 and CC2). These
#=GF CC   coiled-coil domains are also believed to act as rigid spacers to
#=GF CC   delineate the distance between the ONM and INM of the NE.
#=GF CC   Furthermore, the two coiled-coil domains of SUN2 have been
#=GF CC   indicated to be able to directly modulate SUN domain activity
#=GF CC   and regulate the subsequent interactions between the SUN and
#=GF CC   KASH domains. CC2 forms a three-helix bundle to lock the SUN
#=GF CC   domain in an inactive conformation acting as an inhibitory
#=GF CC   component. Structure-based sequence analysis demonstrated that
#=GF CC   several Gly residues are located in the flexible linker regions
#=GF CC   between the three helices which would ideally provide the
#=GF CC   breaks/turns in CC2 for three-helix bundle formation. The last
#=GF CC   helix alpha3 of CC2 (that is immediately connected to the SUN
#=GF CC   domain) has been shown to be an essential segment for promoting
#=GF CC   SUN domain trimerization in the SUN-KASH complex structure
#=GF CC   [1,2].
#=GF SQ   245
#=GS F6RAR8_HORSE/571-629        AC F6RAR8.1
#=GS K7F9C1_PELSI/481-538        AC K7F9C1.1
#=GS A0A218UZX8_9PASE/476-533    AC A0A218UZX8.1
#=GS L5KFC6_PTEAL/681-739        AC L5KFC6.1
#=GS A0A2K5HZG2_COLAP/444-502    AC A0A2K5HZG2.1
#=GS A0A2I3TP25_PANTR/465-523    AC A0A2I3TP25.1
#=GS S7P2L4_MYOBR/550-608        AC S7P2L4.1
#=GS A0A091MIW2_9PASS/636-694    AC A0A091MIW2.1
#=GS A0A286Y1L4_CAVPO/643-701    AC A0A286Y1L4.1
#=GS W5M0J4_LEPOC/693-751        AC W5M0J4.1
#=GS A0A093J9Y3_STRCA/375-432    AC A0A093J9Y3.1
#=GS A0A091E028_FUKDA/491-548    AC A0A091E028.1
#=GS I3LQX0_PIG/553-611          AC I3LQX0.2
#=GS F1RIY7_PIG/678-736          AC F1RIY7.3
#=GS A0A1U7R5T7_MESAU/679-737    AC A0A1U7R5T7.1
#=GS A0A091M890_CARIC/129-186    AC A0A091M890.1
#=GS A0A091HI51_CALAN/478-535    AC A0A091HI51.1
#=GS SUN1_MOUSE/676-734          AC Q9D666.2
#=GS SUN1_MOUSE/676-734          DR PDB; 5YWZ A; 676-734;
#=GS F6S3X7_XENTR/439-496        AC F6S3X7.1
#=GS A0A091W5W8_OPIHO/393-450    AC A0A091W5W8.1
#=GS R4GFT6_CHICK/465-519        AC R4GFT6.2
#=GS J9NSY5_CANLF/489-546        AC J9NSY5.1
#=GS A0A2I3MZC6_PAPAN/444-502    AC A0A2I3MZC6.1
#=GS H3A677_LATCH/479-533        AC H3A677.1
#=GS H7C2K3_HUMAN/265-323        AC H7C2K3.1
#=GS L8Y468_TUPCH/286-344        AC L8Y468.1
#=GS A0A091GKX8_9AVES/629-687    AC A0A091GKX8.1
#=GS A0A2I3HC82_NOMLE/547-605    AC A0A2I3HC82.1
#=GS G3T5D1_LOXAF/503-560        AC G3T5D1.1
#=GS A0A1U8CJT8_MESAU/521-579    AC A0A1U8CJT8.1
#=GS A0A2K5KQ45_CERAT/444-502    AC A0A2K5KQ45.1
#=GS A0A2I3T1E6_PANTR/651-709    AC A0A2I3T1E6.1
#=GS K7D7D4_PANTR/548-606        AC K7D7D4.1
#=GS A0A1D5QLZ0_MACMU/444-502    AC A0A1D5QLZ0.1
#=GS A0A2I3FVI0_NOMLE/584-642    AC A0A2I3FVI0.1
#=GS A0A2I3MVT3_PAPAN/657-715    AC A0A2I3MVT3.1
#=GS A0A099YVU2_TINGU/636-694    AC A0A099YVU2.1
#=GS A0A0A0A9R8_CHAVO/435-492    AC A0A0A0A9R8.1
#=GS A0A287AKA4_PIG/608-666      AC A0A287AKA4.1
#=GS G3I2J5_CRIGR/494-551        AC G3I2J5.1
#=GS H0ZJ94_TAEGU/476-533        AC H0ZJ94.1
#=GS A0A091EXH2_CORBR/477-534    AC A0A091EXH2.1
#=GS A0A093C948_9AVES/436-493    AC A0A093C948.1
#=GS I2CYJ6_MACMU/484-541        AC I2CYJ6.1
#=GS A0A2K5KPZ5_CERAT/547-605    AC A0A2K5KPZ5.1
#=GS A0A096NK39_PAPAN/593-650    AC A0A096NK39.1
#=GS A0A091TUW8_PHORB/143-200    AC A0A091TUW8.1
#=GS A0A091IAQ5_CALAN/641-699    AC A0A091IAQ5.1
#=GS E1BQ86_CHICK/670-728        AC E1BQ86.3
#=GS M7AYJ6_CHEMY/591-649        AC M7AYJ6.1
#=GS A0A2I0MJA5_COLLI/476-533    AC A0A2I0MJA5.1
#=GS A0A099ZY22_CHAVO/629-687    AC A0A099ZY22.1
#=GS G3HUQ1_CRIGR/679-737        AC G3HUQ1.1
#=GS A0A099ZH05_TINGU/446-503    AC A0A099ZH05.1
#=GS Q5U2W0_RAT/520-578          AC Q5U2W0.1
#=GS A0A091TFM0_PHALP/124-181    AC A0A091TFM0.1
#=GS A0A2K5KPZ8_CERAT/694-752    AC A0A2K5KPZ8.1
#=GS A0A2I3TSJ0_PANTR/666-724    AC A0A2I3TSJ0.1
#=GS A0A151N1M1_ALLMI/583-640    AC A0A151N1M1.1
#=GS L5LSQ8_MYODS/447-505        AC L5LSQ8.1
#=GS A0A2K5KQ36_CERAT/584-642    AC A0A2K5KQ36.1
#=GS A0A0P7TFP1_9TELE/305-362    AC A0A0P7TFP1.1
#=GS G7P249_MACFA/572-630        AC G7P249.1
#=GS A0A1U7SNY9_ALLSI/674-731    AC A0A1U7SNY9.1
#=GS A0A1U8C912_MESAU/678-736    AC A0A1U8C912.1
#=GS E7F184_DANRE/343-399        AC E7F184.1
#=GS A0A2K5NL97_CERAT/484-541    AC A0A2K5NL97.1
#=GS G1RYX5_NOMLE/485-542        AC G1RYX5.3
#=GS A0A1V4J9Z8_PATFA/886-943    AC A0A1V4J9Z8.1
#=GS A0A091MXK2_APAVI/645-703    AC A0A091MXK2.1
#=GS M3Z2G3_MUSPF/685-743        AC M3Z2G3.1
#=GS A0A2I3TXJ0_PANTR/577-635    AC A0A2I3TXJ0.1
#=GS A0A151N1Z9_ALLMI/574-631    AC A0A151N1Z9.1
#=GS F6RQM4_MONDO/494-551        AC F6RQM4.1
#=GS U3IMU7_ANAPL/688-746        AC U3IMU7.1
#=GS A0A091GH79_9AVES/463-516    AC A0A091GH79.1
#=GS A0A1U8DGC7_ALLSI/663-720    AC A0A1U8DGC7.1
#=GS F6T6D4_CALJA/491-548        AC F6T6D4.1
#=GS S7QAZ5_MYOBR/484-541        AC S7QAZ5.1
#=GS F7FC46_MACMU/460-517        AC F7FC46.2
#=GS A0A093GF83_DRYPU/466-523    AC A0A093GF83.1
#=GS A0A093J8H0_STRCA/637-695    AC A0A093J8H0.1
#=GS A0A2I3MGV9_PAPAN/547-605    AC A0A2I3MGV9.1
#=GS G1MTG5_MELGA/697-755        AC G1MTG5.2
#=GS G1P0Y4_MYOLU/517-574        AC G1P0Y4.1
#=GS A0A1L8GNT0_XENLA/473-530    AC A0A1L8GNT0.1
#=GS T0MCK8_CAMFR/730-786        AC T0MCK8.1
#=GS A0A1V4KS67_PATFA/670-728    AC A0A1V4KS67.1
#=GS A6QLV1_BOVIN/492-549        AC A6QLV1.1
#=GS SUN2_MOUSE/495-552          AC Q8BJS4.3
#=GS SUN2_MOUSE/495-552          DR PDB; 5ED8 A; 463-520;
#=GS A0A2K5HZA5_COLAP/463-521    AC A0A2K5HZA5.1
#=GS A0A1A6GSL9_NEOLE/677-735    AC A0A1A6GSL9.1
#=GS A0A2I3RKF4_PANTR/444-502    AC A0A2I3RKF4.1
#=GS A0A286ZUE8_PIG/548-606      AC A0A286ZUE8.1
#=GS A0A1S3FUU3_DIPOR/509-566    AC A0A1S3FUU3.1
#=GS A0A091DZT8_FUKDA/702-760    AC A0A091DZT8.1
#=GS A0A2K5NLN8_CERAT/484-541    AC A0A2K5NLN8.1
#=GS A0A2I3SDL1_PANTR/650-708    AC A0A2I3SDL1.1
#=GS A0A0D9RY80_CHLSB/678-736    AC A0A0D9RY80.1
#=GS F6RJG8_HORSE/680-738        AC F6RJG8.1
#=GS A0A2K5JCU8_COLAP/485-542    AC A0A2K5JCU8.1
#=GS A0A226NJP5_CALSU/1210-1268  AC A0A226NJP5.1
#=GS A0A1U7QVN2_MESAU/554-612    AC A0A1U7QVN2.1
#=GS A0A091W1M8_NIPNI/476-533    AC A0A091W1M8.1
#=GS U3KDA8_FICAL/483-540        AC U3KDA8.1
#=GS W5KNM3_ASTMX/777-836        AC W5KNM3.1
#=GS A0A2I3SGD7_PANTR/687-745    AC A0A2I3SGD7.1
#=GS H9GAB9_ANOCA/102-160        AC H9GAB9.1
#=GS A0A091EPT6_CORBR/627-685    AC A0A091EPT6.1
#=GS A0A2I0M0R9_COLLI/670-728    AC A0A2I0M0R9.1
#=GS A0A1U8BK33_MESAU/185-242    AC A0A1U8BK33.1
#=GS E9PHI4_HUMAN/584-642        AC E9PHI4.1
#=GS U3KHQ5_FICAL/669-727        AC U3KHQ5.1
#=GS A0A1V4KS77_PATFA/629-687    AC A0A1V4KS77.1
#=GS A0A2D0Q9N2_ICTPU/401-459    AC A0A2D0Q9N2.1
#=GS H0V6Q8_CAVPO/491-548        AC H0V6Q8.2
#=GS F6RJA0_HORSE/581-639        AC F6RJA0.1
#=GS F7HLL7_MACMU/694-752        AC F7HLL7.2
#=GS A0A1U7SLM8_TARSY/116-173    AC A0A1U7SLM8.1
#=GS H0Y742_HUMAN/472-530        AC H0Y742.1
#=GS A0A093I6F0_DRYPU/632-690    AC A0A093I6F0.1
#=GS A0A226MZT4_CALSU/379-433    AC A0A226MZT4.1
#=GS U3J370_ANAPL/415-469        AC U3J370.1
#=GS A0A2I3SWT4_PANTR/548-606    AC A0A2I3SWT4.1
#=GS W5LYM1_LEPOC/128-183        AC W5LYM1.1
#=GS A0A2I3SQV0_PANTR/514-572    AC A0A2I3SQV0.1
#=GS G3RA70_GORGO/415-473        AC G3RA70.2
#=GS V8NTM3_OPHHA/843-896        AC V8NTM3.1
#=GS G1KHB8_ANOCA/482-535        AC G1KHB8.2
#=GS W5P7L0_SHEEP/577-635        AC W5P7L0.1
#=GS I3KKD7_ORENI/759-819        AC I3KKD7.1
#=GS A0A1S3FSC8_DIPOR/682-740    AC A0A1S3FSC8.1
#=GS H0ZDQ1_TAEGU/327-385        AC H0ZDQ1.1
#=GS A0A218V7D7_9PASE/587-645    AC A0A218V7D7.1
#=GS A0A286ZN31_PIG/462-519      AC A0A286ZN31.1
#=GS A0A087QLR5_APTFO/448-505    AC A0A087QLR5.1
#=GS G1RAI6_NOMLE/650-708        AC G1RAI6.3
#=GS A0A1S3FRE6_DIPOR/632-690    AC A0A1S3FRE6.1
#=GS L5MLD4_MYODS/597-654        AC L5MLD4.1
#=GS A0A2I3TDZ8_PANTR/577-635    AC A0A2I3TDZ8.1
#=GS A0A2I3GJK9_NOMLE/513-571    AC A0A2I3GJK9.1
#=GS A0A091L9Q9_CATAU/265-323    AC A0A091L9Q9.1
#=GS F6SF78_ORNAN/492-549        AC F6SF78.1
#=GS A0A1U7SY63_TARSY/295-353    AC A0A1U7SY63.1
#=GS H2P4E4_PONAB/485-542        AC H2P4E4.1
#=GS A0A2I3HB29_NOMLE/579-637    AC A0A2I3HB29.1
#=GS A0A0Q3XBN0_AMAAE/1260-1317  AC A0A0Q3XBN0.1
#=GS W5Q366_SHEEP/568-625        AC W5Q366.1
#=GS G1LH55_AILME/683-741        AC G1LH55.1
#=GS SUN1_HUMAN/574-632          AC O94901.3
#=GS A0A1A6GVP1_NEOLE/469-526    AC A0A1A6GVP1.1
#=GS A0A2I3M1H7_PAPAN/464-522    AC A0A2I3M1H7.1
#=GS E2R4M4_CANLF/586-644        AC E2R4M4.2
#=GS G5AYT8_HETGA/497-554        AC G5AYT8.1
#=GS W5KAQ0_ASTMX/94-151         AC W5KAQ0.1
#=GS A0A094L9I0_9AVES/622-680    AC A0A094L9I0.1
#=GS A0A087RFV1_APTFO/628-686    AC A0A087RFV1.1
#=GS H2PL98_PONAB/730-788        AC H2PL98.2
#=GS H2QU30_PANTR/585-643        AC H2QU30.2
#=GS A0A091H681_BUCRH/436-493    AC A0A091H681.1
#=GS A0A096N6S5_PAPAN/694-752    AC A0A096N6S5.1
#=GS A0A091MVF4_9PASS/435-492    AC A0A091MVF4.1
#=GS A0A1U7S280_ALLSI/480-537    AC A0A1U7S280.1
#=GS G1THH7_RABIT/387-444        AC G1THH7.2
#=GS H3B4W3_LATCH/685-743        AC H3B4W3.1
#=GS F7B1Y2_CALJA/523-580        AC F7B1Y2.1
#=GS G1LW79_AILME/510-567        AC G1LW79.1
#=GS H3B4W5_LATCH/308-366        AC H3B4W5.1
#=GS A0A1S3WDY4_ERIEU/681-739    AC A0A1S3WDY4.1
#=GS A0A2K5HZF2_COLAP/583-641    AC A0A2K5HZF2.1
#=GS A0A2I2YKV9_GORGO/381-439    AC A0A2I2YKV9.1
#=GS V8NXY7_OPHHA/290-343        AC V8NXY7.1
#=GS A0A2I2ZZ03_GORGO/478-535    AC A0A2I2ZZ03.1
#=GS H0UY87_CAVPO/709-767        AC H0UY87.2
#=GS A0A091WDV9_NIPNI/629-687    AC A0A091WDV9.1
#=GS A0A2I0MJA7_COLLI/463-520    AC A0A2I0MJA7.1
#=GS A0A2I3G549_NOMLE/477-534    AC A0A2I3G549.1
#=GS A0A2I2YDX4_GORGO/481-538    AC A0A2I2YDX4.1
#=GS A0A286ZLF8_PIG/594-652      AC A0A286ZLF8.1
#=GS A0A091QM31_MERNU/433-490    AC A0A091QM31.1
#=GS A0A093BDN0_CHAPE/474-531    AC A0A093BDN0.1
#=GS A0A2I3GPG4_NOMLE/444-502    AC A0A2I3GPG4.1
#=GS A0A2I0M0R1_COLLI/564-622    AC A0A2I0M0R1.1
#=GS A0A2K5HZ57_COLAP/546-604    AC A0A2K5HZ57.1
#=GS F1SNX8_PIG/494-551          AC F1SNX8.3
#=GS A0A093FAW9_GAVST/625-683    AC A0A093FAW9.1
#=GS E2RL48_CANLF/524-581        AC E2RL48.2
#=GS G3TG49_LOXAF/529-587        AC G3TG49.1
#=GS F7AJ01_MOUSE/1-57           AC F7AJ01.1
#=GS A0A0D9R2D4_CHLSB/484-541    AC A0A0D9R2D4.1
#=GS F7I378_CALJA/579-637        AC F7I378.1
#=GS A0A2I3TIC0_PANTR/651-709    AC A0A2I3TIC0.1
#=GS A0A2K5KQ33_CERAT/464-522    AC A0A2K5KQ33.1
#=GS A0A2I3RZ36_PANTR/581-639    AC A0A2I3RZ36.1
#=GS I3M385_ICTTR/682-740        AC I3M385.2
#=GS E2R8J5_CANLF/686-744        AC E2R8J5.2
#=GS A0A2I0M0Q4_COLLI/637-695    AC A0A2I0M0Q4.1
#=GS A0A2I3SZ93_PANTR/585-643    AC A0A2I3SZ93.1
#=GS A0A0G2K016_RAT/678-736      AC A0A0G2K016.1
#=GS H0Y6N5_HUMAN/396-454        AC H0Y6N5.1
#=GS H0WGK7_OTOGA/524-581        AC H0WGK7.1
#=GS A0A2I3TT81_PANTR/478-535    AC A0A2I3TT81.1
#=GS A0A1U8C902_MESAU/613-671    AC A0A1U8C902.1
#=GS A0A093NW29_PYGAD/628-686    AC A0A093NW29.1
#=GS A0A151N1H4_ALLMI/624-681    AC A0A151N1H4.1
#=GS F7I3L0_CALJA/266-324        AC F7I3L0.1
#=GS M3WQ86_FELCA/513-570        AC M3WQ86.2
#=GS A0A1S2ZHB7_ERIEU/490-547    AC A0A1S2ZHB7.1
#=GS A0A2I3MC96_PAPAN/584-642    AC A0A2I3MC96.1
#=GS A0A287B648_PIG/599-657      AC A0A287B648.1
#=GS A0A1S3FWD8_DIPOR/507-564    AC A0A1S3FWD8.1
#=GS A0A093QDB5_9PASS/627-685    AC A0A093QDB5.1
#=GS H2R4A1_PANTR/481-538        AC H2R4A1.1
#=GS H9G4J6_ANOCA/676-734        AC H9G4J6.2
#=GS L9K7J8_TUPCH/519-576        AC L9K7J8.1
#=GS F7CXX7_ORNAN/695-753        AC F7CXX7.2
#=GS A0A287AL99_PIG/520-578      AC A0A287AL99.1
#=GS A0A2I3NC27_PAPAN/678-736    AC A0A2I3NC27.1
#=GS A0A151NHP2_ALLMI/976-1033   AC A0A151NHP2.1
#=GS A0A1L8GH06_XENLA/442-499    AC A0A1L8GH06.1
#=GS F6SWL9_HORSE/676-734        AC F6SWL9.1
#=GS A0A226PCW5_COLVI/379-423    AC A0A226PCW5.1
#=GS A0A091TBZ9_PHALP/624-682    AC A0A091TBZ9.1
#=GS D3ZTT7_RAT/494-551          AC D3ZTT7.1
#=GS I3MTN3_ICTTR/490-547        AC I3MTN3.2
#=GS F6TPB5_HORSE/490-547        AC F6TPB5.1
#=GS M3XGS8_LATCH/635-693        AC M3XGS8.1
#=GS A0A091JBY1_EGRGA/624-682    AC A0A091JBY1.1
#=GS H0X4Z0_OTOGA/676-734        AC H0X4Z0.1
#=GS G5BUE9_HETGA/634-692        AC G5BUE9.1
#=GS A0A091Q7J4_LEPDC/438-495    AC A0A091Q7J4.1
#=GS H3B4W4_LATCH/309-367        AC H3B4W4.1
#=GS W5M0H6_LEPOC/741-799        AC W5M0H6.1
#=GS L5KFV6_PTEAL/553-610        AC L5KFV6.1
#=GS K7FA13_PELSI/695-752        AC K7FA13.1
#=GS G1NL78_MELGA/132-186        AC G1NL78.2
#=GS A0A226PRL6_COLVI/478-536    AC A0A226PRL6.1
#=GS SUN2_HUMAN/481-538          AC Q9UH99.3
#=GS SUN2_HUMAN/481-538          DR PDB; 4DXT A; 522-538;
#=GS SUN2_HUMAN/481-538          DR PDB; 3UNP A; 520-537;
#=GS SUN2_HUMAN/481-538          DR PDB; 4DXR A; 522-538;
#=GS SUN2_HUMAN/481-538          DR PDB; 4DXS A; 522-538;
#=GS SUN2_HUMAN/481-538          DR PDB; 4FI9 A; 523-538;
#=GS A0A287APF8_PIG/632-690      AC A0A287APF8.1
#=GS M7AP36_CHEMY/389-446        AC M7AP36.1
#=GS M3YP27_MUSPF/486-543        AC M3YP27.1
#=GS F6RMJ1_MOUSE/171-229        AC F6RMJ1.1
#=GS A0A1U7UNM7_TARSY/489-546    AC A0A1U7UNM7.1
#=GS F6TCF6_MONDO/691-749        AC F6TCF6.2
#=GS S9XGU1_CAMFR/56-114         AC S9XGU1.1
F6RAR8_HORSE/571-629                   ...v-QVLLRDLELQILKNITHHISVTKQM.pTSETVVS.AVNEAG.ISGITEAQARAIVDNALKL..
K7F9C1_PELSI/481-538                   ....LQDKLRELEHRILASVSEGQRLSARD..AKASIGV.ALQQEG.VTGVTEEQVHVIVNRALQR..
A0A218UZX8_9PASE/476-533               ....LQAELQALERKILAKVLEDRRLSARD..AQAGIGV.ALRQGG.TAGVTEEQVHLIVGQALKR..
L5KFC6_PTEAL/681-739                   ....LQVLLRDLELRILKEVTHRVSVTKQI.pTSETIMS.AVNDAG.VSGITEAQAHVIVNNALKL..
A0A2K5HZG2_COLAP/444-502               ....LHTMLRDLELQILRNVTHHISVTKRL.pASEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A2I3TP25_PANTR/465-523               ....LHTMLRDLQLQILRNVTHHVSVTKRL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
S7P2L4_MYOBR/550-608                   ....LQALLRELELQILKNITHHISVTRQG.pTSEAIMA.AVTSEG.TSGITEAQARVIVNNALKL..
A0A091MIW2_9PASS/636-694               ....LQTLLQDLELQILKNITLHMSVTNQK.vTSEVVTS.AVSNAG.ISGITEAQAQIIVNNALKL..
A0A286Y1L4_CAVPO/643-701               ....LQTLLRDLELQVLKNITHHLVVTGQK.pTSETVVS.AVSEAG.ISGITEEQARVIVNNALKL..
W5M0J4_LEPOC/693-751                   ....LQGRLASLEQRVFKNITSYTSQTKQM.pTAQVVTS.AVNGAG.VTGITEEQVHAIVNNALRL..
A0A093J9Y3_STRCA/375-432               ....LQAELQALERKILAKVLEDRRLSARD..AQAGIGV.ALQQGG.MAGVTEEQVHLIVNQALKR..
A0A091E028_FUKDA/491-548               ....VQAQLQELESKILTHVTEMQGKSARE..AAALLGR.TLQKEG.VVGVTEEQVQRIVKQALQR..
I3LQX0_PIG/553-611                     ....LQVLLRELELGILKNVTHHLAVTKQT.pAPETVVS.AARGAG.ITGITEAQAQVLVNKALKL..
F1RIY7_PIG/678-736                     ....LQVLLRELELGILKNVTHHLAVTKQT.pAPETVVS.AARGAG.ITGITEAQAQVLVNKALKL..
A0A1U7R5T7_MESAU/679-737               ....LQVLLRDLELKVLQNITHHITVTGQV.pTSETIVS.AMSEAG.VSGITEAQAHIIVNNALKL..
A0A091M890_CARIC/129-186               ....LEAELQALEHKILAKILEDRRLSARD..AQGGVGV.ALQQGG.TAGVTEEQVHLIVGQALKR..
A0A091HI51_CALAN/478-535               ....LQAELRALERRILDKVQEDQRLSARD..AQAGIGV.ALRQGG.TTGVTEEQVHLIVAQALKR..
SUN1_MOUSE/676-734                     ....LQVLLHDLELKLLQNITHHITVTGQA.pTSEAIVS.AVNQAG.ISGITEAQAHIIVNNALKL..
#=GR SUN1_MOUSE/676-734          SS    ....HHHHHHHHHHHHHHHHHHHHHHHSS-.--HHHHHH.HHHHTT.-----HHHHHHHHHHHHHH..
F6S3X7_XENTR/439-496                   ....LQKHLVELERKILAGIATERNEWAAR..AHTSVDR.ELQAGG.LSGITREEVHEIVNRAIQ-t.
A0A091W5W8_OPIHO/393-450               ....LQAELQALERKILDKVLEDRRLSAQD..AQAGIGV.ALQQGG.TAGVTEEQVHLIVGQALKR..
R4GFT6_CHICK/465-519                   ....LQAELRALELRILAQMREERGLAARD..---SIGV.ALRQGG.AGGVTEEQVHLIVDQALKR..
J9NSY5_CANLF/489-546                   ....MQAQLQELENKILAHVAEMQGKSARE..AAASLGL.TLQKEG.VIGVTEEQVQRIVNQALKR..
A0A2I3MZC6_PAPAN/444-502               ....LHTMLRDLELQILRNVTHHISVTKRL.pASEVVVS.AVSEAG.ASGITEAQARAIVNNALKL..
H3A677_LATCH/479-533                   ....LQRILQELEGSLRREVST-QGSSFRA..--DVVGE.TLEAAG.ITEVSMEVVSRIVDRALRL..
H7C2K3_HUMAN/265-323                   ....LQTMLRDLQLQILRNVTHHVSVTKQL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNSALKL..
L8Y468_TUPCH/286-344                   ....LQILLRDLELQILKNITYHISVTNQV.pTSETVVS.AVNEAG.ISGITEAQARVIVNNALKL..
A0A091GKX8_9AVES/629-687               ....LQALLQNLEKQILKNITLHMSLTKEK.lTPEVVTN.AVANAG.ISGITEAQVQIIVNNALKL..
A0A2I3HC82_NOMLE/547-605               ....LRTRLRDLELQILRNVTHHVSVTKQL.pTSEAMVS.AVSEVG.ASGITEAQARAIVNNALKL..
G3T5D1_LOXAF/503-560                   ...i-EARLQELESRILAHMAETQGKSVKE..AAASLGL.MLQKEG.MIGVTEEQVHHIVSQALKR..
A0A1U8CJT8_MESAU/521-579               ....LQVLLRDLELKVLQNITHHITVTGQV.pTSETIVS.AMSEAG.VSGITEAQAHIIVNNALKL..
A0A2K5KQ45_CERAT/444-502               ....LHTMLRDLELQILRNVTHHISVTKRL.pASEVVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A2I3T1E6_PANTR/651-709               ....LHTMLRDLQLQILRNVTHHVSVTKRL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
K7D7D4_PANTR/548-606                   ....LHTMLRDLQLQILRNVTHHVSVTKRL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A1D5QLZ0_MACMU/444-502               ....LHTMLRDLELQILRNVTHHISVTKRL.pASEVVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A2I3FVI0_NOMLE/584-642               ....LRTRLRDLELQILRNVTHHVSVTKQL.pTSEAMVS.AVSEVG.ASGITEAQARAIVNNALKL..
A0A2I3MVT3_PAPAN/657-715               ....LHTMLRDLELQILRNVTHHISVTKRL.pASEVVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A099YVU2_TINGU/636-694               ....LQTLLQDLELQILKNITLYMSSTNQK.lTSEVVTN.AVNNAG.VSGITEAQAHVIVNNALKL..
A0A0A0A9R8_CHAVO/435-492               ....LQAELQALEHKILAKVLEDQRLLARD..TRAGIGV.ALQQGG.TMGVTEEQVHLIVGQALKR..
A0A287AKA4_PIG/608-666                 ....LQVLLRELELGILKNVTHHLAVTKQT.pAPETVVS.AARGAG.ITGITEAQAQVLVNKALKL..
G3I2J5_CRIGR/494-551                   ....LHAQLQELESKILASMAEMQGKSARE..AAASLGQ.TLQKEG.VVGVTEEQVHQIVKQALQR..
H0ZJ94_TAEGU/476-533                   ....LQAELQALERKILAKVQEDRRLSARD..AQAGIGV.ALRQGG.TAGVTEEQVHLIVGQALKR..
A0A091EXH2_CORBR/477-534               ....LQAELQALERKILAKVLEDWRLSARD..AQAGIGV.ALRQGG.TAGVTEEQVHLIVGQALKR..
A0A093C948_9AVES/436-493               ....LQAELQALERKILDKVLEDRRLSARD..AKASIGV.ALQQGG.TAGVTEEQVHLIVGQALKR..
I2CYJ6_MACMU/484-541                   ....MQAQLRELESKILTHVAEMQGKSARE..AAASLGM.TLQKEG.VIGVTEEQVHRIVKQALQR..
A0A2K5KPZ5_CERAT/547-605               ....LHTMLRDLELQILRNVTHHISVTKRL.pASEVVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A096NK39_PAPAN/593-650               ....MQAQLRELESKILTHVAEMQGKSARE..AAASLGV.TLQKEG.VIGVTEEQVHRIVKQALQR..
A0A091TUW8_PHORB/143-200               ....LQAELQALERKILAKVLEDRRLSARD..AQGGIGV.AVRQGG.TAGVTEEQVHLIVGQALKR..
A0A091IAQ5_CALAN/641-699               ....LQTSLRELELQILKNISLHLSVTNQK.lTSEVVTN.AVTNAG.ISGITEAQAQVIVNNALKL..
E1BQ86_CHICK/670-728                   ....LQTLLQDLELQILKNITVQMAVTNQR.iTSEVVTN.AVNNAG.ISGITEAQAQIIVNNALKL..
M7AYJ6_CHEMY/591-649                   ....LQVLLQDLELQILKNITLHMSITNQK.pTSEVVTS.AVNNAV.ISGITEAQARIIVNNALKL..
A0A2I0MJA5_COLLI/476-533               ....LQAELQALESKILAKVLEDRRLSAQD..AQARIGV.ALRQGG.ATGVTEEQVHLIVDQALKR..
A0A099ZY22_CHAVO/629-687               ....LQTLLQNLELQILKNITLHMSVTNQK.lTPEVVTN.AVTNAG.ISGITEAVIQIIVNNALKL..
G3HUQ1_CRIGR/679-737                   ....LQVLLHDLELKVLQNITHHVTVTGQA.pTSEAIVS.AMSEAG.ISGITEAQAHIIVNNALKL..
A0A099ZH05_TINGU/446-503               ....LQAELQALERKILAKVLEDRRLSARD..AQAGIGV.ALRQGG.MAGVTEEQVHLIVSQALQR..
Q5U2W0_RAT/520-578                     ....LQVLLHDLELKLLQNITHHITVTGQA.pTSEAIVS.AMSQAG.ISGITEAQAHIIVNNALRL..
A0A091TFM0_PHALP/124-181               ....LQAELQALERKILARVLEDRRLSARD..AQAGMRV.ALQQGG.TAGVTEEQVHLIVGQALRR..
A0A2K5KPZ8_CERAT/694-752               ....LHTMLRDLELQILRNVTHHISVTKRL.pASEVVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A2I3TSJ0_PANTR/666-724               ....LHTMLRDLQLQILRNVTHHVSVTKRL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A151N1M1_ALLMI/583-640               ....LQTLLQDLEMRILKNISFHMSVSNQK.sTSEIVTS.AVNA-G.ISGISEAQARIIVNNALKL..
L5LSQ8_MYODS/447-505                   ....LQALLRELELQILKNITHHISVTRQG.pTSEAIMA.AVTSEG.TSGITEAQARVIVNNALKL..
A0A2K5KQ36_CERAT/584-642               ....LHTMLRDLELQILRNVTHHISVTKRL.pASEVVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A0P7TFP1_9TELE/305-362               ....LQQALGDLERRLLQKLAEEREKEQPD..MWRSVGE.TLQREG.AGAVTVEDIQQIVHRALRL..
G7P249_MACFA/572-630                   ....LHTMLRDLELQILRNVTHHISVTKRL.pASEVVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A1U7SNY9_ALLSI/674-731               ....LQTLLQDLEMRILKNISFHMSVSNQK.sTSEIVTS.AVNA-G.ISGISEAQARIIVNNALKL..
A0A1U8C912_MESAU/678-736               ....LQVLLRDLELKVLQNITHHITVTGQV.pTSETIVS.AMSEAG.VSGITEAQAHIIVNNALKL..
E7F184_DANRE/343-399                   ....LQRALQDLEKQILEKLAHEKG-SSRD..VWRTVGE.TLQQEG.AGAATIQDVKEIVHRAIS-l.
A0A2K5NL97_CERAT/484-541               ....MQAQLRELESKILTHVAEMQGKSARE..AAASLGV.TLQKEG.VIGVTEEQVNRIVKQALQR..
G1RYX5_NOMLE/485-542                   ....MQAQLRELESKILTHVAEMQGKSARE..AAASLGL.TLQKEG.VIGVTEEQVHHIVKQALQR..
A0A1V4J9Z8_PATFA/886-943               ....LQGELQALESKIVAKVLKDRRLSAQD..AQAGIGV.ALRQGG.AAGVTEEQVHLIVDQALKR..
A0A091MXK2_APAVI/645-703               ....LQGLLQDLELQILENITLHMSVTNQK.lTSEVVTN.AVTNAG.ISGITEAQAHIIVKNALKL..
M3Z2G3_MUSPF/685-743                   ....LQALLRDLELQILKNITHYISVTKQV.pDSETVVS.AAKEAG.VSGITEAQARVIVNNALKL..
A0A2I3TXJ0_PANTR/577-635               ....LHTMLRDLQLQILRNVTHHVSVTKRL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A151N1Z9_ALLMI/574-631               ....LQTLLQDLEMRILKNISFHMSVSNQK.sTSEIVTS.AVNA-G.ISGISEAQARIIVNNALKL..
F6RQM4_MONDO/494-551                   ....VQAQLRDLEHRILTQMAEEQGKFVRE..TAARVEQ.TLDKEG.EVGITEEKVHRIVNQALKR..
U3IMU7_ANAPL/688-746                   ....LQTLLQDLELQILKNITQHMAITNQR.vTSEVVTN.VVNNAG.ICGITEAQAQIIVNNALKL..
A0A091GH79_9AVES/463-516               ....LQTELQSLEQKILAKVLEDQALLVQD..VQAGTGV.AVRE--.--GVTEEQVHHIVSQALQR..
A0A1U8DGC7_ALLSI/663-720               ....LQTLLQDLEMRILKNISFHMSVSNQK.sTSEIVTS.AVNA-G.ISGISEAQARIIVNNALKL..
F6T6D4_CALJA/491-548                   ....MQAQLRDLENKILTHIAEMQGKSARE..AAASLGL.TLQKEG.VIGVTEEQVHRIVKQALQR..
S7QAZ5_MYOBR/484-541                   ....MQARLQELEGKILSHVAEMQGKSARE..AVASVGL.RLQKEG.VIGVTEEEVHRIVNQALKR..
F7FC46_MACMU/460-517                   ....MQAQLRELESKILTHVAEMQGKSARE..AAASLGM.TLQKEG.VIGVTEEQVHRIVKQALQR..
A0A093GF83_DRYPU/466-523               ....LQAELQALERKILAKISEDQRLSAQG..AQAGSGV.ALQRGG.TAGVTEEKVHLIVDQALKR..
A0A093J8H0_STRCA/637-695               ....LQTLLQDLELQILKNITLHMSSTNQK.lTSEVVTN.AVNNVG.VSGITEAQARIIVNNALKL..
A0A2I3MGV9_PAPAN/547-605               ....LHTMLRDLELQILRNVTHHISVTKRL.pASEVVVS.AVSEAG.ASGITEAQARAIVNNALKL..
G1MTG5_MELGA/697-755                   ....LQTLLQDLELQILKNITLQMAVTDQR.iTSEVVTN.AVNNAG.ISGITEAQAQIIVNNALKL..
G1P0Y4_MYOLU/517-574                   ....MQARLQELEGKILRHVAEMQGKSAKE..AVASMGL.RLQKEG.VIGVTEEEVQRIVNQALKR..
A0A1L8GNT0_XENLA/473-530               ....LQRHLVELERKILAGIATERNAWAAH..AHTSVDR.ELQAGG.LSGITREEVHDIVNRAIQR..
T0MCK8_CAMFR/730-786                   ....MQAQLQELESKVLAHVAEMQGKSARE..AVASLGL.TLQKEG.VIGVTEE-VHHIVNQALKR..
A0A1V4KS67_PATFA/670-728               ....LQAALRDLELRILKDITLRVSVTNQK.pTSEIVTS.AVTNAG.ISGVTEEQVQVIVNNALKL..
A6QLV1_BOVIN/492-549                   ....MEAQLRDLESRILTHVAEMQGKSARE..AVASLGL.TLQREG.VIGVTEEQVHRIVNQALKR..
SUN2_MOUSE/495-552                     ....MHAQLQELENKILTKMAEMQGKSARE..AAASLGQ.ILQKEG.IVGVTEEQVHRIVKQALQR..
#=GR SUN2_MOUSE/495-552          SS    ....HHHHHHHHHHHHHHHHGGGTTS-HHH..HHHHHHH.HHTTS-.-S---HHHHHHHHHHHTTS..
A0A2K5HZA5_COLAP/463-521               ....LHTMLRDLELQILRNVTHHISVTKRL.pASEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A1A6GSL9_NEOLE/677-735               ...v-QVLLRDLELKVLQNITHHITVTGQS.pTSEAIVS.AMTEAG.ISGITEAQAHIIVNNALKL..
A0A2I3RKF4_PANTR/444-502               ....LHTMLRDLQLQILRNVTHHVSVTKRL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A286ZUE8_PIG/548-606                 ....LQVLLRELELGILKNVTHHLAVTKQT.pAPETVVS.AARGAG.ITGITEAQAQVLVNKALKL..
A0A1S3FUU3_DIPOR/509-566               ...v-HTQLQELERQILAHVAEMQGKSVSQ..AAALLGQ.TLQKEG.VVGVTEEQVHRIVKQALQR..
A0A091DZT8_FUKDA/702-760               ....LQALLRDLELQVLKNITHHLVITGQK.pTSETVVS.AVSGAG.ISGITEAQARVIVNNALKL..
A0A2K5NLN8_CERAT/484-541               ....MQAQLRELESKILTHVAEMQGKSARE..AAASLGV.TLQKEG.VIGVTEEQVNRIVKQALQR..
A0A2I3SDL1_PANTR/650-708               ....LHTMLRDLQLQILRNVTHHVSVTKRL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A0D9RY80_CHLSB/678-736               ....LHTMLRDLELQILRNVTHHIAVTKQL.pASEVVVS.AVSDAG.ASGITEAQARAIVNNALKL..
F6RJG8_HORSE/680-738                   ...v-QVLLRDLELQILKNITHHISVTKQM.pTSETVVS.AVNEAG.ISGITEAQARAIVDNALKL..
A0A2K5JCU8_COLAP/485-542               ....MQAQLRELESKILTHVAEMQGKSARE..AAASLGV.TLQKEG.VIGVTEEQVHRIVKQALQR..
A0A226NJP5_CALSU/1210-1268             ....LQALLQDLELQILKNITLQMAVTNRS.iTSEVVTN.AVTNAG.ISGITEAQAQIIVNNALKL..
A0A1U7QVN2_MESAU/554-612               ....LQVLLRDLELKVLQNITHHITVTGQV.pTSETIVS.AMSEAG.VSGITEAQAHIIVNNALKL..
A0A091W1M8_NIPNI/476-533               ....LQAELRALEHKILAKVLEDRRLSARD..AQAGIGV.ALRQGG.TAGVTEEQVHLIVGQALKR..
U3KDA8_FICAL/483-540                   ....LQAELQALEHKILAKVLEDRRLSARD..AQAGIGV.ALRQGG.TAGVTEEQVHLIVGQALKR..
W5KNM3_ASTMX/777-836                   ....LQASLAALERSILGNVSLQVEQTQQK.pCAETVTKaVLKTTG.DAGLSETQVQLIVQNALKL..
A0A2I3SGD7_PANTR/687-745               ....LHTMLRDLQLQILRNVTHHVSVTKRL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
H9GAB9_ANOCA/102-160                   lrvl----LQDLESRILRNITLHMSVTNTK.sASEVVTS.VVNEAG.IAGITEAQARLIVNNALKL..
A0A091EPT6_CORBR/627-685               ....LQTLLRDLELQILKNITLHMSVTNQK.vTSEVVTN.AVTNAG.ISGITEAQAQIIVNNALKL..
A0A2I0M0R9_COLLI/670-728               ....LQASLRDLELRILKDITLRVSVTNQK.pTSEIVTT.AMTNAG.ISGVTEEQVHVIVNNALKL..
A0A1U8BK33_MESAU/185-242               ....LHAQLQELESKILASMAEMQGKSARE..AAASLGR.TLQKEG.VVGVTEEQVHRIVKQALQR..
E9PHI4_HUMAN/584-642                   ....LQTMLRDLQLQILRNVTHHVSVTKQL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNSALKL..
U3KHQ5_FICAL/669-727                   ....LQTLLRDLELQILKNITLHMSVTNQK.vTSEVVTN.AVTNAG.ISGITEAQAQIIVNNALKL..
A0A1V4KS77_PATFA/629-687               ....LQAALRDLELRILKDITLRVSVTNQK.pTSEIVTS.AVTNAG.ISGVTEEQVQVIVNNALKL..
A0A2D0Q9N2_ICTPU/401-459               ....LQRALEDLEKKILDRLGQEREDKERV.dVWRTVGE.TLQEEG.VGAVSVTDVERIVHRALS-l.
H0V6Q8_CAVPO/491-548                   ....VQAQLQELESKILAHVTKMQGRSAQE..AAALLGQ.TLQKEG.VVGVTEEQVHRIVKQALQR..
F6RJA0_HORSE/581-639                   ...v-QVLLRDLELQILKNITHHISVTKQM.pTSETVVS.AVNEAG.ISGITEAQARAIVDNALKL..
F7HLL7_MACMU/694-752                   ....LHTMLRDLELQILRNVTHHISVTKRL.pASEVVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A1U7SLM8_TARSY/116-173               ....VQTQLQELESRIFAHVTEMQGRSARE..TATSLGL.TLQKEG.MVGVTEEQVHRIVKQALQR..
H0Y742_HUMAN/472-530                   ....LQTMLRDLQLQILRNVTHHVSVTKQL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNSALKL..
A0A093I6F0_DRYPU/632-690               ....LQTLLQDLELKILRNITLHMSVTNQK.lTSEVVTN.AVANAG.ISGITEAQAQMIVNNALKL..
A0A226MZT4_CALSU/379-433               ....LQAELRALELRILAQMREERGLAAPD..---SIGV.ALRQGG.AGGVTEEQVHLIVDQALKR..
U3J370_ANAPL/415-469                   ....LQEELQALEHKILAKMQEERRLSARE..ASAGIGV.ALRPGG.AGGVTEEQVHLIVDQA---..
A0A2I3SWT4_PANTR/548-606               ....LHTMLRDLQLQILRNVTHHVSVTKRL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
W5LYM1_LEPOC/128-183                   ....LQEELQDLEQKILARLVQGEGQEW--..AWHSVDK.ILESED.ITAVTLQDVHAITERALKE..
A0A2I3SQV0_PANTR/514-572               ....LHTMLRDLQLQILRNVTHHVSVTKRL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
G3RA70_GORGO/415-473                   ....LHTMLRDLQLQILRNVTHHVSVTKQL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
V8NTM3_OPHHA/843-896                   ....LQEQLRKLEHKILAKILKDQELSVRD..----VGV.TLHKEG.ITGVTEEQVHHIVNDALKR..
G1KHB8_ANOCA/482-535                   ....LQEHLLALEKKILARISEDQEFSVQN..----VRV.ALQREG.VIGVTQEDVHRIVNQALNR..
W5P7L0_SHEEP/577-635                   ....VQALLRDLELQVLRNITHHISVTRQM.pTSETVVS.AVSGAG.VPGITEAQARVIVNNALKL..
I3KKD7_ORENI/759-819                   ....LQASLASLELSILRNISQQLEAESRAksIVQTVTG.TVRHASaAEGLTEEQVKLIVQNALKL..
A0A1S3FSC8_DIPOR/682-740               ....LQVLLQDLELQVLKNVSHHISVTGQV.pTSEAIVS.AVSEAG.ISGITEAQARVIVNNALKL..
H0ZDQ1_TAEGU/327-385                   ....LQTLLRDLELQILKNITLHMSVTNQK.vTSEVVTN.AVTNAG.ISGITEAQAQIIVNNALKL..
A0A218V7D7_9PASE/587-645               ....LQTLLRDLELQILKNITLHMSVTNQK.vTSEVVTN.AVTNAG.ISGITEAQAQIIVNNALKL..
A0A286ZN31_PIG/462-519                 ....MQAQLQELESKILAHVAEMQGKSARE..AVASLGL.TLQKEG.VIGVTEEQVHRIVKQALKR..
A0A087QLR5_APTFO/448-505               ....LQAELQALERKILAKVLEDRRLSARD..AQAGIGV.ALRQGG.TTGVTEEQVHLIVGQALKR..
G1RAI6_NOMLE/650-708                   ....LRTRLRDLELQILRNVTHHVSVTKQL.pTSEAMVS.AVSEVG.ASGITEAQARAIVNNALKL..
A0A1S3FRE6_DIPOR/632-690               ....LQVLLQDLELQVLKNVSHHISVTGQV.pTSEAIVS.AVSEAG.ISGITEAQARVIVNNALKL..
L5MLD4_MYODS/597-654                   ....MQARLQELEGKILSHVAEMQGKSARE..AAASVGL.RLQKEG.VVGVTEEEVHRIVNQALKR..
A0A2I3TDZ8_PANTR/577-635               ....LHTMLRDLQLQILRNVTHHVSVTKRL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A2I3GJK9_NOMLE/513-571               ....LRTRLRDLELQILRNVTHHVSVTKQL.pTSEAMVS.AVSEVG.ASGITEAQARAIVNNALKL..
A0A091L9Q9_CATAU/265-323               ....LQILLQDLELQILKNITLHMSVRNQK.lTSEVVTN.AVANAG.ISGITEAQAQIIVNNALKL..
F6SF78_ORNAN/492-549                   ....LHDQLQKLEHKILAHLAQERGKSAQE..AAAGLGV.VLRKEG.VTGVTEEQVHHIVSQALKR..
A0A1U7SY63_TARSY/295-353               ....LQATLRGLELQILRNLSHHVSVMKQA.pPAEAVVS.AVKEAG.ISGITEAQAHAIVNNALRL..
H2P4E4_PONAB/485-542                   ....MQAQLRELESKILTHVAEMQGKLARE..AAASLGL.TLQKEG.VIGVTEEQVHHIVKQALQR..
A0A2I3HB29_NOMLE/579-637               ....LRTRLRDLELQILRNVTHHVSVTKQL.pTSEAMVS.AVSEVG.ASGITEAQARAIVNNALKL..
A0A0Q3XBN0_AMAAE/1260-1317             ....-QTELQDLELRILKDINLXMSATKQK.lTPEVITN.AVTNAG.ISGITEEQVQVIVNNALKL..
W5Q366_SHEEP/568-625                   ....MEAQLRDLESKILTHVAEMQGKSARE..AVASLGL.TLQREG.VIGVTEEQVHRIVSQALKR..
G1LH55_AILME/683-741                   ....LQVLLRDLELQILKNVTHYISVTKRV.pDSETVVS.AAKEAG.ISGITEAQARVIVNNALKL..
SUN1_HUMAN/574-632                     ....LQTMLRDLQLQILRNVTHHVSVTKQL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNSALKL..
A0A1A6GVP1_NEOLE/469-526               ....MHAQLQELESKILASMAEMQGKSARE..AAASLGW.TLQKEG.VVGVTEEQVHQXVKQALQR..
A0A2I3M1H7_PAPAN/464-522               ....LHTMLRDLELQILRNVTHHISVTKRL.pASEVVVS.AVSEAG.ASGITEAQARAIVNNALKL..
E2R4M4_CANLF/586-644                   ....LQVLLRDLELQILKNITHYISVTKQV.pDSETVVS.AANEAG.ISGITEAQARVIVNNALKL..
G5AYT8_HETGA/497-554                   ....VQAQLQELESKILTHVTEMQGKSTQE..AAALLGQ.TLQKEG.MVGVTEEQVHQIVKQALQR..
W5KAQ0_ASTMX/94-151                    ....LQRALEALEKKIMDRLGEEREKESGD..VWGTVGV.TLREEG.AGELTVKDVERIVNRALS-l.
A0A094L9I0_9AVES/622-680               ....LQTLLRDLELQILKNITLHMSVTNEK.lTSEVVTN.TVTNAG.ICGITEAQAQVIVNNALKL..
A0A087RFV1_APTFO/628-686               ....LQTLLRDLELQILKNITLHMSVTNQK.lTSEVVTN.VVTNAG.ISGITEAVTQIIVNNALKL..
H2PL98_PONAB/730-788                   ....LHTMLRDLELQILRNVTHHVSVTKQL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
H2QU30_PANTR/585-643                   ....LHTMLRDLQLQILRNVTHHVSVTKRL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A091H681_BUCRH/436-493               ....LQAELQALERKILAKVLEDQRLSARG..AQAGIGV.ALQQGG.AAGVTEEQVHHIVGQALKR..
A0A096N6S5_PAPAN/694-752               ....LHTMLRDLELQILRNVTHHISVTKRL.pASEVVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A091MVF4_9PASS/435-492               ....LQAELQALERKILAKVSEDRRLSARD..AQAGIGV.ALRQGG.TAGVTEEQVHLIVDQALKR..
A0A1U7S280_ALLSI/480-537               ....LQDQLQEMEHRILAKISEDQQMSAQD..ARASVRV.ALQQGG.VMAVTEEEVHLIVNRALKR..
G1THH7_RABIT/387-444                   ....LQAQLRELESKILAQVAETQGTSARE..AAAALSL.TLQREG.VIGVTEEQVHRIVKQALQR..
H3B4W3_LATCH/685-743                   ...f-QSVLQDLEMRILKNITLYRAEFKQM.pTAEVVTG.AITNVG.ITGITEEQARVIVKNALN-l.
F7B1Y2_CALJA/523-580                   ....MQAQLRDLENKILTHIAEMQGKSARE..AAASLGL.TLQKEG.VIGVTEEQVHRIVKQALQR..
G1LW79_AILME/510-567                   ....LQAQLQELESKILAHVAEMQGRSASE..AAASLGL.TLQKEG.VIGVTEEQVQRIVNQALKR..
H3B4W5_LATCH/308-366                   ...f-QSVLQDLEMRILKNITLYRAEFKQM.pTAEVVTG.AITNVG.ITGITEEQARVIVKNALN-l.
A0A1S3WDY4_ERIEU/681-739               ....LQALLRDIEMQILSNVTHHISVTKQT.lTSETVAS.AMSEAG.VSGITEAQARVIVDNALKL..
A0A2K5HZF2_COLAP/583-641               ....LHTMLRDLELQILRNVTHHISVTKRL.pASEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A2I2YKV9_GORGO/381-439               ....LHTMLRDLQLQILRNVTHHVSVTKQL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
V8NXY7_OPHHA/290-343                   ....LQEQLCKLKHKVLAKILKNQELSVQD..----VEI.TLHKEG.ITGLTEEQIHHIVNDALK-h.
A0A2I2ZZ03_GORGO/478-535               ....MQAQLRELESKILTHVAEMQGKSARE..AAASLGL.TLQKEG.VIGVTEEQVHHIVKQALQR..
H0UY87_CAVPO/709-767                   ....LQTLLRDLELQVLKNITHHLVVTGQK.pTSETVVS.AVSEAG.ISGITEEQARVIVNNALKL..
A0A091WDV9_NIPNI/629-687               ....LQTLLRDLELQILKNITLHMSATNQK.vTSEVVTN.AVTNAG.ISGITEAQAQIIVNNALKL..
A0A2I0MJA7_COLLI/463-520               ....LQAELQALESKILAKVLEDRRLSAQD..AQARIGV.ALRQGG.ATGVTEEQVHLIVDQALKR..
A0A2I3G549_NOMLE/477-534               ....MQAQLRELESKILTHVAEMQGKSARE..AAASLGL.TLQKEG.VIGVTEEQVHHIVKQALQR..
A0A2I2YDX4_GORGO/481-538               ....MQAQLRELESKILTHVAEMQGKSARE..AAASLGL.TLQKEG.VIGVTEEQVHHIVKQALQR..
A0A286ZLF8_PIG/594-652                 ....LQVLLRELELGILKNVTHHLAVTKQT.pAPETVVS.AARGAG.ITGITEAQAQVLVNKALKL..
A0A091QM31_MERNU/433-490               ....LQAELQALERKILAKVSEDQRLLARD..AQAGIGV.ALRQGG.TTGVTEEQVHLIVGQALKR..
A0A093BDN0_CHAPE/474-531               ....LQAELQALERKILAKVLEDRRLSARD..AQGGIGV.ALQQGG.TAGVTEEQVHLIVEQALKR..
A0A2I3GPG4_NOMLE/444-502               ....LRTRLRDLELQILRNVTHHVSVTKQL.pTSEAMVS.AVSEVG.ASGITEAQARAIVNNALKL..
A0A2I0M0R1_COLLI/564-622               ....LQASLRDLELRILKDITLRVSVTNQK.pTSEIVTT.AMTNAG.ISGVTEEQVHVIVNNALKL..
A0A2K5HZ57_COLAP/546-604               ....LHTMLRDLELQILRNVTHHISVTKRL.pASEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
F1SNX8_PIG/494-551                     ....MQAQLQELESKILAHVAEMQGKSARE..AVASLGL.TLQKEG.VIGVTEEQVHRIVKQALKR..
A0A093FAW9_GAVST/625-683               ....LQTLLRDLELQILKNITLHMSVTNQK.lTSEVVTN.AVTNAG.ISGITEAQAQIIVNNALKL..
E2RL48_CANLF/524-581                   ....MQAQLQELENKILAHVAEMQGKSARE..AAASLGL.TLQKEG.VIGVTEEQVQRIVNQALKR..
G3TG49_LOXAF/529-587                   ....LQILLRDLELQVLKNITHHISVTKQA.pTSAAVVS.AMHEAG.VPGITEAQARIIVNNALKL..
F7AJ01_MOUSE/1-57                      ..xl----LHDLELKLLQNITHHITVTGQA.pTSEAIVS.AVNQAG.ISGITEAQAHIIVNNALKL..
A0A0D9R2D4_CHLSB/484-541               ....MQAQLRELESKILTHVAEMQGKSARE..AAASLGV.TLQKEG.VIGVTEEQVHRIVKQALQR..
F7I378_CALJA/579-637                   ..lh--MLLRDLELQILRNVTHHISVTKHT.pTSEAVVS.AVSEAG.MSGITEAQARAIVNNALKL..
A0A2I3TIC0_PANTR/651-709               ....LHTMLRDLQLQILRNVTHHVSVTKRL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A2K5KQ33_CERAT/464-522               ....LHTMLRDLELQILRNVTHHISVTKRL.pASEVVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A2I3RZ36_PANTR/581-639               ....LHTMLRDLQLQILRNVTHHVSVTKRL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
I3M385_ICTTR/682-740                   ....LQVLLQDLELQVLKNITHHITVTGQA.pTSEAVVS.AMSNAG.VSGITEEQVRVLVNKALKL..
E2R8J5_CANLF/686-744                   ....LQVLLRDLELQILKNITHYISVTKQV.pDSETVVS.AANEAG.ISGITEAQARVIVNNALKL..
A0A2I0M0Q4_COLLI/637-695               ....LQASLRDLELRILKDITLRVSVTNQK.pTSEIVTT.AMTNAG.ISGVTEEQVHVIVNNALKL..
A0A2I3SZ93_PANTR/585-643               ....LHTMLRDLQLQILRNVTHHVSVTKRL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A0G2K016_RAT/678-736                 ....LQVLLHDLELKLLQNITHHITVTGQA.pTSEAIVS.AMSQAG.ISGITEAQAHIIVNNALRL..
H0Y6N5_HUMAN/396-454                   ....LQTMLRDLQLQILRNVTHHVSVTKQL.pTSEAVVS.AVSEAG.ASGITEAQARAIVNSALKL..
H0WGK7_OTOGA/524-581                   ....MQAQLQELENRILAHMAEMQGKSATE..AAASLGL.TLQKEG.VIGVTEEQVHRIVKQALQR..
A0A2I3TT81_PANTR/478-535               ....MQAQLRELESKILTHVAEMQGKSARE..AAASLGL.TLQKEG.VIGVTEEQVHHIVKQALQR..
A0A1U8C902_MESAU/613-671               ....LQVLLRDLELKVLQNITHHITVTGQV.pTSETIVS.AMSEAG.VSGITEAQAHIIVNNALKL..
A0A093NW29_PYGAD/628-686               ....LQTLLRDLELQILKNITLHMSVTNQK.lTSEVVTN.AVTNAG.ISGITEAVTQIIVNNALKL..
A0A151N1H4_ALLMI/624-681               ....LQTLLQDLEMRILKNISFHMSVSNQK.sTSEIVTS.AVNA-G.ISGISEAQARIIVNNALKL..
F7I3L0_CALJA/266-324                   ..lh--MLLRDLELQILRNVTHHISVTKHT.pTSEAVVS.AVSEAG.MSGITEAQARAIVNNALKL..
M3WQ86_FELCA/513-570                   ....MQVQLRELEGRILAHVAEMRGESARE..AAASLGL.TLQREG.VIGVTEEQVQRIVNQALKR..
A0A1S2ZHB7_ERIEU/490-547               ...v-EAKLQELESKILAHTAKMQGKSAKE..VVASLGL.TLQKEG.ANGMTEEQVHRIVNQALKR..
A0A2I3MC96_PAPAN/584-642               ....LHTMLRDLELQILRNVTHHISVTKRL.pASEVVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A287B648_PIG/599-657                 ....LQVLLRELELGILKNVTHHLAVTKQT.pAPETVVS.AARGAG.ITGITEAQAQVLVNKALKL..
A0A1S3FWD8_DIPOR/507-564               ...v-HTQLQELERQILAHVAEMQGKSVSQ..AAALLGQ.TLQKEG.VVGVTEEQVHRIVKQALQR..
A0A093QDB5_9PASS/627-685               ....LQTLLRDLELQILKNITLHMSVTNQK.lTSEVVTN.AVTNAG.ISGITEAQAQIIVNNALKL..
H2R4A1_PANTR/481-538                   ....MQAQLRELESKILTHVAEMQGKSARE..AAASLGL.TLQKEG.VIGVTEEQVHHIVKQALQR..
H9G4J6_ANOCA/676-734                   lrvl----LQDLESRILRNITLHMSVTNTK.sASEVVTS.VVNEAG.IAGITEAQARLIVNNALKL..
L9K7J8_TUPCH/519-576                   ....MEAQLQELERKILAHVAEMQGQSARE..AAASLGL.TLQREG.VIGVTEAQVHRIVKQALQR..
F7CXX7_ORNAN/695-753                   ....LQVLLQDLELQILKNISLHMSLTKET.pTSETVIT.AVRSVG.ISGITEAQAHTIVNNALKL..
A0A287AL99_PIG/520-578                 ....LQVLLRELELGILKNVTHHLAVTKQT.pAPETVVS.AARGAG.ITGITEAQAQVLVNKALKL..
A0A2I3NC27_PAPAN/678-736               ....LHTMLRDLELQILRNVTHHISVTKRL.pASEVVVS.AVSEAG.ASGITEAQARAIVNNALKL..
A0A151NHP2_ALLMI/976-1033              ....LQDQLQEMEHRILAKISEDQQMSAQD..ARASVRV.ALQQGG.VMAVTEEEVHLIVNRALKR..
A0A1L8GH06_XENLA/442-499               ....LQKHLVELERKILAGIATERNEWAAR..AHTSVDR.ELQAGG.LSEITKKEVHDIVNRAIQR..
F6SWL9_HORSE/676-734                   ...v-QVLLRDLELQILKNITHHISVTKQM.pTSETVVS.AVNEAG.ISGITEAQARAIVDNALKL..
A0A226PCW5_COLVI/379-423               ....LQAELRALELRILAQMREERGLAARD..---SIGV.ALRQGG.AGGVTEE------------sf
A0A091TBZ9_PHALP/624-682               ....LQTLLRDLELQILKNITLHMSVTNQK.lTSEVVTN.AVTNAG.ISGITEAQAQIIVNNALKL..
D3ZTT7_RAT/494-551                     ....MHAQLQELENKILANMAEMQGKSARE..AAASLGQ.TLQKEG.IVGVTEEQVHRIVKQALQR..
I3MTN3_ICTTR/490-547                   ....MQVQLQELESKILSHMAEMQGKSARE..AVASLGL.TLQKEG.MVGVTEEQVHRIVKQALQR..
F6TPB5_HORSE/490-547                   ....IQAQLQELESKILAHMAEMQGKSARE..AAASLGL.TLQKEG.VIGVTEEQVHRIVKQALKR..
M3XGS8_LATCH/635-693                   ...f-QSVLQDLEMRILKNITLYRAEFKQM.pTAEVVTG.AITNVG.ITGITEEQARVIVKNALN-l.
A0A091JBY1_EGRGA/624-682               ....LQTLLRDLELQILKNITLHMSVTNQK.lTSEVVTN.AVTNAG.ISGITEAQAQIIVNNALKL..
H0X4Z0_OTOGA/676-734                   ....LQILLQDLELQILKNITHHISVTKQM.pTSETVVS.AVHKAG.VSGITEAQARVIVNNALKL..
G5BUE9_HETGA/634-692                   ....LQVLLRDLELQVLKNITHHLVVTGQK.lTSETVVS.AVSGAG.ISGITEAQARVIVNNALKL..
A0A091Q7J4_LEPDC/438-495               ....LQAELQALERKILAKVLEDRRLSARD..AQAGIGV.ALRQGG.TAGVTEEQVHLIVGQALKR..
H3B4W4_LATCH/309-367                   ...f-QSVLQDLEMRILKNITLYRAEFKQM.pTAEVVTG.AITNVG.ITGITEEQARVIVKNALN-l.
W5M0H6_LEPOC/741-799                   ....LQGRLASLEQRVFKNITSYTSQTKQM.pTAQVVTS.AVNGAG.VTGITEEQVHAIVNNALRL..
L5KFV6_PTEAL/553-610                   ....MQAQLRELESKVLAHVAEMQGKSARE..AAAILGR.TLQKEG.VIGVTEEEVHRIVNQALKR..
K7FA13_PELSI/695-752                   ....LQVLLQDLELQILKNITLHMSITNQK.pTSEVVTS.AVNA-G.ISGITEAQARIIVNNALKL..
G1NL78_MELGA/132-186                   ....LQAELRALELRILAQMREERGLAARD..---SIGV.ALRQGG.AGGVTEEQVHLIVDQALKR..
A0A226PRL6_COLVI/478-536               ....LQALLQDLELQILKNITLQMAVTNRS.iTSEVVTN.AVNKAG.ISGITEAQAQIIVNNALKL..
SUN2_HUMAN/481-538                     ....MQAQLRELESKILTHVAEMQGKSARE..AAASLSL.TLQKEG.VIGVTEEQVHHIVKQALQR..
#=GR SUN2_HUMAN/481-538          SS    ....XXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXX.XXXXXX.XXS--HHHHHHHHHHHHHH..
A0A287APF8_PIG/632-690                 ....LQVLLRELELGILKNVTHHLAVTKQT.pAPETVVS.AARGAG.ITGITEAQAQVLVNKALKL..
M7AP36_CHEMY/389-446                   ....LQDQLQKLERKILARVSEDQRMSARD..AKASIGV.ALQQEG.VTGVTEEQVHLIVNQALKR..
M3YP27_MUSPF/486-543                   ....MQAQLQELERKILAHVAEMQGKSARE..AAASLGL.TLQKEG.VIGVTEEQVQRIVNQALKR..
F6RMJ1_MOUSE/171-229                   ....LQVLLHDLELKLLQNITHHITVTGQA.pTSEAIVS.AVNQAG.ISGITEAQAHIIVNNALKL..
A0A1U7UNM7_TARSY/489-546               ....VQTQLQELESRIFAHVTEMQGRSARE..TATSLGL.TLQKEG.MVGVTEEQVHRIVKQALQR..
F6TCF6_MONDO/691-749                   ....LQILLRDLELQILKNITHHMSMTKEI.pSSETVVN.AVNSLG.ISGITEAQAHAIVNNALKL..
S9XGU1_CAMFR/56-114                    ....LQVLLRELELQILRNITHHVSVMKQM.pTSEAVVS.AVNEAG.IPGITEAQARAIVDNALKL..
#=GC SS_cons                           ....HHHHHHHHHHHHHHHHHHHCCCHCCH..HHHHHHH.HHCCTT.XSS--HHHHHHHHHHHHHH..
#=GC seq_cons                          ....LQshLp-LEhpILpslocchulospp..sucslss.AlppuG.loGlTEtQs+hIVNpALKh..
//
DBGET integrated database retrieval system