GenomeNet

Database: Pfam
Entry: Svs_4_5_6
LinkDB: Svs_4_5_6
Original site: Svs_4_5_6 
#=GF ID   Svs_4_5_6
#=GF AC   PF17381.4
#=GF DE   Seminal vesicle secretory proteins 4/5/6
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   PRODOM:PD067130
#=GF GA   25.00 25.00;
#=GF TC   26.50 26.30;
#=GF NC   19.20 17.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   27486266
#=GF RT   Seminal vesicle proteins SVS3 and SVS4 facilitate SVS2 effect on
#=GF RT   sperm capacitation.
#=GF RA   Araki N, Kawano N, Kang W, Miyado K, Yoshida K, Yoshida M;
#=GF RL   Reproduction. 2016;152:313-321.
#=GF RN   [2]
#=GF RM   11422369
#=GF RT   Synthesis of novel anti-inflammatory peptides derived from the
#=GF RT   amino-acid sequence of the bioactive protein SV-IV.
#=GF RA   Ialenti A, Santagada V, Caliendo G, Severino B, Fiorino F,
#=GF RA   Maffia P, Ianaro A, Morelli F, Di Micco B, Carteni M, Stiuso P,
#=GF RA   Metafora V, Metafora S;
#=GF RL   Eur J Biochem. 2001;268:3399-3406.
#=GF DR   INTERPRO; IPR035409;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   There are seven major proteins involved in murine seminal
#=GF CC   vesicle secretion (SVS1-7). Mouse Svs2-Svs6 genes evolved by
#=GF CC   gene duplication and belong to the same gene family [1]. This
#=GF CC   domain family is found in SVS4/5 and 6. SVS4 is a basic,
#=GF CC   thermostable, secretory protein synthesized by rat seminal
#=GF CC   vesicle epithelium under strict androgen transcriptional
#=GF CC   control. This protein has potent nonspecies-specific
#=GF CC   immunomodulatory, anti-inflammatory, and pro-coagulant
#=GF CC   activities that have been shown to be located in the N-terminal
#=GF CC   region of Svs4 (fragment 1-70) [2]. The N-terminal segment has a
#=GF CC   high amino-acid sequence similarity with the C-terminal segment
#=GF CC   34-66 of uteroglobin, a rabbit steroid-inducible, cytokine-like,
#=GF CC   multifunctional, secreted protein. Furthermore, SVS4 acts as a
#=GF CC   sperm capacitation inhibitor, by interacting with SVS3 and SVS2
#=GF CC   [1].
#=GF SQ   11
#=GS SVS4_MOUSE/24-109        AC P18419.2
#=GS SVS5_MOUSE/22-122        AC P30933.1
#=GS A0A0G2JSZ2_RAT/24-107    AC A0A0G2JSZ2.1
#=GS SVS4_RAT/24-108          AC P02783.1
#=GS D3ZJA4_RAT/24-95         AC D3ZJA4.1
#=GS SVS6_MOUSE/24-95         AC Q64356.1
#=GS F6RYE9_MOUSE/1-49        AC F6RYE9.1
#=GS A0A1A6HJI0_NEOLE/23-106  AC A0A1A6HJI0.1
#=GS A0A0G2JTC7_RAT/24-122    AC A0A0G2JTC7.1
#=GS Q9D268_MOUSE/24-95       AC Q9D268.1
#=GS SVS5_RAT/24-122          AC P04812.1
SVS4_MOUSE/24-109                   ..................................TKEKFLQSEETVRESF..........----SMGSRGHMSRSSEPEVFVRPQDSIGDEASEEMSSssssrRRSKIISSSSDGSNM------EGESSYSKRK.KSRFSQ..........
SVS5_MOUSE/22-122                   ..................................ARERFSQSAEDPSSSHmgikiraggsGSGSAMEEYSVSENSWSNFKSKHPSSISSESFHEESSS.....SSEMSSSGGHFGLKMRGSQAGGGMSSFKTRV.KSRILK..........
A0A0G2JSZ2_RAT/24-107               ..................................TKEKYSQSEEVVSESF..........ASGPSSGSS-DELVRDKPYGPKVSGGSFGEEASEEISS.....RRSKHISRSSGGSNM------EGESSYAKKK.RSRFAQ..........
SVS4_RAT/24-108                     ..................................TKEKYSQSEEVVSESF..........ASGPSSGSSDDELVRDKPYGPKVSGGSFGEEASEEISS.....RRSKHISRSSGGSNM------EGESSYAKKK.RSRFAQ..........
D3ZJA4_RAT/24-95                    ..................................PREKFSQSAEDFSSE-..........-----------------SSEAKIPKSVIHEDVYEEKKF.....TRDMA--SSDDGDDKRSLSAGEIERSFTRKKdKPRFAQ..........
SVS6_MOUSE/24-95                    ..................................PRERFSQAIEEFSSE-..........-----------------SSEANSPKSIVHEEVYEEKKF.....KRNMV--NGEDGEDSKRASAGEIERSYLRKKeKQRFAQ..........
F6RYE9_MOUSE/1-49                   .................................x----------------..........---------------------------SSESFHEESSS.....SSEMSSSGGHFGLKMRGSQAGGGMSSFKTRV.KSRILK..........
A0A1A6HJI0_NEOLE/23-106             mkeklssalsqgpswqdepyqllppyiapgsgdr----------------..........-SSNYKENPCRSESSWSTLKSKSPKSIVSEEAYEERKH.....KKQ----------------------------.------tgdggyddkt
A0A0G2JTC7_RAT/24-122               ..................................PREKFSQSAEDPYSENmnlkilasgrGSSSTFGAYSRSENSRSNFKSKSPSSITREKVNEES--.....RSEMSSTSSHFGLKMRRSHGGGEMNPFETKV.KTRITR..........
Q9D268_MOUSE/24-95                  ..................................PRERFSQAIEEFSSE-..........-----------------SSEANSPKSIVHEEVYEEKKF.....KRNMV--NGEDGEDSKRASAGEIERSYLRKKeKQQFAQ..........
SVS5_RAT/24-122                     ..................................PREKFSQSAEDPYSENmnlkilasgrGSSSTFGAFSRSENSRSNFKSKSPSSITREKVNEES--.....RSEMSSTSSHFGLKMRRSHGGGEMNPFETKV.KTRITR..........
#=GC seq_cons                       ..................................s+E+FSQStEs.ppp.................tt......p.ps.cuKsPpSlspE-spEEpp......++pMs.osuc.G.cM+t.puGtt.sSatpKh.KoRhsp..........
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