GenomeNet

Database: Pfam
Entry: T3SS_needle_reg
LinkDB: T3SS_needle_reg
Original site: T3SS_needle_reg 
#=GF ID   T3SS_needle_reg
#=GF AC   PF09025.11
#=GF DE   YopR, type III needle-polymerisation regulator
#=GF PI   YopR_core;
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1z21
#=GF GA   25.00 25.00;
#=GF TC   69.80 69.80;
#=GF NC   24.20 19.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   YopR_bacterial_protein_domain
#=GF RN   [1]
#=GF RM   15930010
#=GF RT   Crystal structure of the protease-resistant core domain of
#=GF RT   Yersinia pestis virulence factor YopR. 
#=GF RA   Schubot FD, Cherry S, Austin BP, Tropea JE, Waugh DS; 
#=GF RL   Protein Sci. 2005;14:1679-1683.
#=GF RN   [2]
#=GF RM   19968786
#=GF RT   YopR impacts type III needle polymerization in Yersinia species.
#=GF RA   Blaylock B, Berube BJ, Schneewind O;
#=GF RL   Mol Microbiol. 2010;75:221-229.
#=GF DR   INTERPRO; IPR013349;
#=GF DR   TC; 3.A.6;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The YopR core domain, predominantly found in the
#=GF CC   Gammaproteobacteria virulence factor YopR, is composed of five
#=GF CC   alpha-helices, four of which are arranged in an antiparallel
#=GF CC   bundle. Little is known about this domain, though it may
#=GF CC   contribute to the virulence of the protein YopR [1]. YopR
#=GF CC   controls the selective access of early (YscF, YscI and YscP)
#=GF CC   substrates to the type III secretion machines of yersiniae and
#=GF CC   other Gammaproteobacteriae. YopR is a mobile regulatory
#=GF CC   component thought to function as a checkpoints probing the
#=GF CC   completion of discrete intermediary stages in the assembly of
#=GF CC   the type III injection pathway. The location of secreted YopR
#=GF CC   (into the medium) is directly controlling the secretion of YscF,
#=GF CC   the polymerised needle protein Pfam:PF09392, thereby impacting
#=GF CC   the assembly of type III machines [2].
#=GF SQ   11
#=GS Q9I316_PSEAE/27-142      AC Q9I316.1
#=GS D0Z4V1_PHODD/41-173      AC D0Z4V1.1
#=GS U3AM14_9VIBR/67-209      AC U3AM14.1
#=GS A0A0W7U489_9GAMM/28-155  AC A0A0W7U489.1
#=GS Q7N0U6_PHOLL/39-187      AC Q7N0U6.1
#=GS E3BLT3_9VIBR/36-152      AC E3BLT3.1
#=GS YSCH_YERPE/19-164        AC P68590.1
#=GS YSCH_YERPE/19-164        DR PDB; 1Z21 A; 42-145;
#=GS T0PDT9_PHOTE/39-187      AC T0PDT9.1
#=GS B6VK53_PHOAA/39-187      AC B6VK53.1
#=GS A0A1D9IL18_9PSED/2-101   AC A0A1D9IL18.1
#=GS Q87P26_VIBPA/68-208      AC Q87P26.1
Q9I316_PSEAE/27-142                 ...dqvlafeqalggeppaagrrlagleng--------------..--------------------------.-----------.---ALGERLLQRFAQPLQG--LEADRLELKAMLRAELPLGRQQQTFLLQLLGAVEH......APGGEYLAQLARRELQVLIPLNGMLDNLVRNSHKLDLE
D0Z4V1_PHODD/41-173                 ....................sssnknaspv------------QK..STDIVSQSEAKVTAIKEWYALSQERS.VKGTDKASPE-.--------LLGSFSG-RLLADPPKDREELKVLLSEHFPLGAQKEQALWHSWAKLQD......IPDQELLLDMVRKELSFVIQINSMVKNMLTYSHKLELS
U3AM14_9VIBR/67-209                 ...................efkqdghfdlk---------SLMRS..LNKTFN--NQHDVRNALWYSYNQELA.AKGTENASPV-.LFNVLEEELLGTFSA-SIMTDIPQTREDLKARLADFYHLGAHKEQALFHTWAELKS......QPDMAATVDIIRTELGHVITMNALAKNFMTNSHKIELE
A0A0W7U489_9GAMM/28-155             .........................vapvr--------------..-----SDEVSEDVREAKWQRYRA---.SDPPDKALLAE.LVAPVKEAIQARFGQRTGPVIPAIDLPELRGLLREFDPLGKRRETVLLEVLATTPK......GGEGKHVADLLRRELMTLLPRNAMVDNLLRNSHAIDLE
Q7N0U6_PHOLL/39-187                 ..............................QQMLKERQQRWLQGepLENVLGDLDPATQRKVIWQWYQALSSdKQPSQRAQLQAkLIAPVQERLWSQFGGLAGNIKPPLDMPELRKIVREFAPTGRQQETVLLEVLGEIKP......IPGNEYLSDLIRQELKTLIPRNGMVDNLIRNSHKPDLE
E3BLT3_9VIBR/36-152                 .......................rtsdkrv--------------..------------------------SSrEKTPDSNVSSEiSTPSVKDDSFDRFLN-DLMAKMPKDRQELKALLSEHFSLGKHKEQALIHSLKALKEk....gDPGQAPLMDLVQKEWGFLIQTNAMIKNLVTYSHKLDLE
YSCH_YERPE/19-164                   ...................avstlqpvase-----------LKT.qLENKLKSESAEKTREVLWQQYYA---.SNPPDHAVLEV.LATPVREALLARFGQHQGSVVPAIDLPELRSVLQQFDSFGKRWEAILLQVLEGIKPnesqvgLP---YLSELINKELMILLPSNSIVDSLLHNSHQIDMD
#=GR YSCH_YERPE/19-164        SS    ...................XXXXXXXXXXX-----------XXX.XXXXXXXXX-HHHHHHHHHHHHHH---.-SS--HHHHHH.HHHHHHHHHHHHHTT--S---HHHHHHHHHHHHHHHS-SSHHHHHHHHHHHHT----------H---HHHHHHHHHHHHH-XXXXXXXXXXXXXXXXXXX
T0PDT9_PHOTE/39-187                 ..............................QQTLKERQQRWIRGesLEEVLGDFDPATQRKIAWQWYQTLSTdSQPSQRAQLEGkLIAPVQEHLWSQFGGLTLPVKPQLDLPEFRAVVREFAPTGRQQETVLLKVLGEIKS......LDGNEYLSDLIRRELQTLIPRNGMVDNLIRNSHKLDLE
B6VK53_PHOAA/39-187                 ..............................QQMLKERQQRWLQGepLENVLGDLDPTTQHKTLWQWYQTLSPeSQPSQRAQLEArLTTPVQEHLWSQFGGLALPVKPSLDIPELRAIVREFAPTGRQQETVLLKVLGNIKP......LAGNEYLSDLIRRELQTLIPRNGMVDNLLRNSHKLDLE
A0A1D9IL18_9PSED/2-101              hapaevanpvspvalrvlrtldahrdnerq--------------..--------------------------.-----------.------------------------ARAALKDLIKQEAPFAKQQQDALLRVLGEIKP......LPDTAAASRVINTELRHVIPLAGMIDNLMRYTHKPDLE
Q87P26_VIBPA/68-208                 ..............................KEAETVSKQSVLSS..LKDVIS--DPQTQKEALWYAFHQAKS.AKGTDDAVPE-.LLSVLKQELLGDFAG-QLMAEPPTDRAALKAMLAQSFPLGAQKEQALWHCWAELKS......LPEMTSTVDLVREELSFVIQKNAMVKNIMTHSHKLDLS
#=GC SS_cons                        ...................XXXXXXXXXXX-----------XXX.XXXXXXXXX-HHHHHHHHHHHHHH---.-SS--HHHHHH.HHHHHHHHHHHHHTT--S---HHHHHHHHHHHHHHHS-SSHHHHHHHHHHHHT----------H---HHHHHHHHHHHHH-XXXXXXXXXXXXXXXXXXX
#=GC seq_cons                       ..........................................pt...pphhs..ssts.+phhW..apt..s.spsspcA..p..LhsslpEcLhupFus.ph.scPshDhsEL+ulLp-ahPhG+QpEssLL+lLuplKs......lPstphLuDLlR+ELphLIPpNuMVDNLl+NSHKlDLE
//
DBGET integrated database retrieval system