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Database: Pfam
Entry: T3SSipB
LinkDB: T3SSipB
Original site: T3SSipB 
#=GF ID   T3SSipB
#=GF AC   PF16535.6
#=GF DE   Type III cell invasion protein SipB
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   pdb_3tul
#=GF GA   31.00 31.00;
#=GF TC   31.20 31.20;
#=GF NC   30.90 30.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   8801431
#=GF RT   Functional conservation of the Salmonella and Shigella effectors
#=GF RT   of entry into epithelial cells.
#=GF RA   Hermant D, Menard R, Arricau N, Parsot C, Popoff MY;
#=GF RL   Mol Microbiol. 1995;17:781-789.
#=GF RN   [2]
#=GF RM   7608068
#=GF RT   Homologs of the Shigella IpaB and IpaC invasins are required for
#=GF RT   Salmonella typhimurium entry into cultured epithelial cells.
#=GF RA   Kaniga K, Tucker S, Trollinger D, Galan JE;
#=GF RL   J Bacteriol. 1995;177:3965-3971.
#=GF RN   [3]
#=GF RM   10051653
#=GF RT   The Salmonella invasin SipB induces macrophage apoptosis by
#=GF RT   binding to caspase-1.
#=GF RA   Hersh D, Monack DM, Smith MR, Ghori N, Falkow S, Zychlinsky A;
#=GF RL   Proc Natl Acad Sci U S A. 1999;96:2396-2401.
#=GF RN   [4]
#=GF RM   10972796
#=GF RT   Membrane fusion activity of purified SipB, a Salmonella surface
#=GF RT   protein essential for mammalian cell invasion.
#=GF RA   Hayward RD, McGhie EJ, Koronakis V;
#=GF RL   Mol Microbiol. 2000;37:727-739.
#=GF RN   [5]
#=GF RM   14662750
#=GF RT   A Salmonella protein causes macrophage cell death by inducing
#=GF RT   autophagy.
#=GF RA   Hernandez LD, Pypaert M, Flavell RA, Galan JE;
#=GF RL   J Cell Biol. 2003;163:1123-1131.
#=GF RN   [6]
#=GF RM   16159789
#=GF RT   Multinucleated giant cell formation and apoptosis in infected
#=GF RT   host cells is mediated by Burkholderia pseudomallei type III
#=GF RT   secretion protein BipB.
#=GF RA   Suparak S, Kespichayawattana W, Haque A, Easton A, Damnin S,
#=GF RA   Lertmemongkolchai G, Bancroft GJ, Korbsrisate S;
#=GF RL   J Bacteriol. 2005;187:6556-6560.
#=GF RN   [7]
#=GF RM   22975346
#=GF RT   Membrane topology of Salmonella invasion protein SipB confers
#=GF RT   osmotolerance.
#=GF RA   Asakura H, Ekawa T, Sugimoto N, Momose Y, Kawamoto K, Makino S,
#=GF RA   Igimi S, Yamamoto S;
#=GF RL   Biochem Biophys Res Commun. 2012;426:654-658.
#=GF RN   [8]
#=GF RM   22321794
#=GF RT   The structures of coiled-coil domains from type III secretion
#=GF RT   system translocators reveal homology to pore-forming toxins.
#=GF RA   Barta ML, Dickenson NE, Patil M, Keightley A, Wyckoff GJ,
#=GF RA   Picking WD, Picking WL, Geisbrecht BV;
#=GF RL   J Mol Biol. 2012;417:395-405.
#=GF DR   INTERPRO; IPR032391;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   T3SSipB is a family of pathogenic Gram-negative bacterial
#=GF CC   proteins that invade human intestinal cells via the type III
#=GF CC   secretion system translocators. T3SSipB represents the coiled
#=GF CC   -coil region of the proteins and is shown to be homologous in
#=GF CC   activity to the pore-forming toxins of other Gram-negative
#=GF CC   pathogens, such as colicin Ia [1-8].
#=GF SQ   23
#=GS A9MF89_SALAR/82-234       AC A9MF89.1
#=GS A0A2N8GPZ8_9PSED/83-235   AC A0A2N8GPZ8.1
#=GS A0A1H2AC73_9PSED/79-237   AC A0A1H2AC73.1
#=GS A0A0R0D4Y8_9GAMM/94-264   AC A0A0R0D4Y8.1
#=GS A0A0T9K9X7_9GAMM/99-210   AC A0A0T9K9X7.1
#=GS Q326S9_SHIDS/76-231       AC Q326S9.1
#=GS BIPB_BURPS/99-261         AC Q63K34.1
#=GS W0I129_9GAMM/125-292      AC W0I129.1
#=GS G8Q409_PSEFL/86-238       AC G8Q409.1
#=GS A0A014MER1_9GAMM/121-248  AC A0A014MER1.1
#=GS A0A1I5AWH4_9ENTR/113-274  AC A0A1I5AWH4.1
#=GS Q2NVH6_SODGM/125-293      AC Q2NVH6.1
#=GS A0A1I4LK51_9RHOB/19-160   AC A0A1I4LK51.1
#=GS A0A0X1T887_PSEAA/79-238   AC A0A0X1T887.1
#=GS Q7NUS8_CHRVO/81-233       AC Q7NUS8.1
#=GS A0A2X4WDD8_SALER/1-121    AC A0A2X4WDD8.1
#=GS IPAB_SHIFL/76-231         AC P18011.2
#=GS IPAB_SHIFL/76-231         DR PDB; 5WKQ A; 76-231;
#=GS IPAB_SHIFL/76-231         DR PDB; 3U0C B; 76-224;
#=GS IPAB_SHIFL/76-231         DR PDB; 5WKQ B; 76-230;
#=GS IPAB_SHIFL/76-231         DR PDB; 3U0C A; 76-224;
#=GS A0A239S6G5_9BURK/83-235   AC A0A239S6G5.1
#=GS A0A3S4I3Q7_SALBN/82-234   AC A0A3S4I3Q7.1
#=GS A0A1N7SC18_9BURK/107-269  AC A0A1N7SC18.1
#=GS A0A2H9U8V4_9GAMM/81-233   AC A0A2H9U8V4.1
#=GS SIPB_SALTY/82-234         AC Q56019.1
#=GS SIPB_SALTY/82-234         DR PDB; 3TUL B; 83-227;
#=GS SIPB_SALTY/82-234         DR PDB; 3TUL D; 83-226;
#=GS SIPB_SALTY/82-234         DR PDB; 3TUL A; 82-226;
#=GS SIPB_SALTY/82-234         DR PDB; 3TUL C; 84-225;
#=GS A0A0J6RGR6_9NEIS/79-231   AC A0A0J6RGR6.1
A9MF89_SALAR/82-234                  .....................EGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKAMGLQVSKEFQAALGEA..EKATDIYEESIKKMDTAKSVYDTAAKKLTQAQN.............KLQSMDPSDPGYAKAEAAEGQAR--...KE.AKD.....AKTAF..DKAKK.AADLAGTDA..........................KTKTEQADNILTKFQGT-t................................
A0A2N8GPZ8_9PSED/83-235              .................gdlf----TLLMAMISELIGEVDVKKLKNRLAMLQSMAGARQQGHEKLAAEYASAVEAL..EAAEGEIGSSQEHLDQLQERVRQVQGLLDKSEA.............RLAELDPESPEYARELALRDKLK--...GE.LAG.....HTQTL..QKATD.AHLKLIEIA..........................NACAKTLAAVAVKVQE--ag...............................
A0A1H2AC73_9PSED/79-237              ................egefv-----RLIASLVELLGNTSLETLKNRLSLLRSVAQASQQSLQRLSADYAQSLAEL..AAAQGAVDSSQERLEALKARLDQAQFELEAAES.............HLASLDPSSPEYAGALARRDRAMGV...VD.TLQqgfrpVAEAH..VRLLD.TAKVAAVKA..........................EALVRQIQDLA-------vrhpat...........................
A0A0R0D4Y8_9GAMM/94-264              .................qslr----TWALGELQQSLGKQGFDHIEQRRHTHRSTLDARVQRAEHLSAEMRAALDAA..TAAQDAAEAAAGEVGAEQGALEAAREHVQQLQS.............ELDALQPNDPARAAKQEELAA---A...RE.VLQ.....Q---A..QQRFDaAAQALCEAA..........................LELDAK------------lgeldeleatlrgfnqgqamvagyterklssad
A0A0T9K9X7_9GAMM/99-210              ...................dg--SLLLLLTQMLNLSSEMALSKLSSNLSILMSTLDARKKEGERVNAEIDKAMGET..EQALSEFEDAVNQLGSANKNLTQKKEQLDQAKS.............DLDKLKKEGVE--------------...--.---.....-----..-----.---------..........................------------------kddpryisaekkv....................
Q326S9_SHIDS/76-231                  .....................SSQLTLLIGNLIQILGEKSLTALTNKITAWKSQQQARQQKNLEFSDKINTLLSET..EGLTRDYEKQINKLKNADSKIKDLENKINQIQT.............RLSELAPDSPEKKKLRREEIQLTIK...KD.AAV.....KDRTLieQKTLS.IHSKLTDKS..........................MQLEKEIDSFSA-FSNT-a................................
BIPB_BURPS/99-261                    .....................AAKLTELLGVLMSVISASSLDELKQRSDIWNQMSKAAQDNLSRLSDAFQRATDEA..KAAADAAEQAAAAAKQAGADAKAADAAVDAAQKryddavkqglpddRLQSL------KAALEQARQQAGDAhgrAD.ALQ.....ADA--..TKKLD.AASALATQA..........................RACEQQVDDAVNQATQQY.................................
W0I129_9GAMM/125-292                 ...................ma--SLTYIMGTIIKLTGNKSIQQLSNNLAAYLAQSKGTQTAAAAMSAELELAASKW..AECEDNLTAAQQQADQLQSAAAQAKQAASDALK.............SLKEL--------QAQAAKETAA--...--.NGS.....VSPEL..QKKID.AATALCEKAdaeasrtknesdkfvtntlnpaitaaNSSRSNLDAVRAKV----ggf..............................
G8Q409_PSEFL/86-238                  .................gdlf----TLLMAMISELIGEVDVKKLKNRLAMLQSMAGARQQGHENLSAEYAAAVEAM..AAAEGNVGSSQEHLDQLQERVLHFQALLQESEV.............RLAQLDPESPEYAQELALRDQLR--...GD.VAS.....HTQTL..QTATA.AHLKLIEVA..........................NACARTVTAVVAKMQE--ss...............................
A0A014MER1_9GAMM/121-248             ...................le--KLTKLLGRMIELNAQSSMHSLQSNVNSFNAIFESTRSAFNELSSQLIQQGENV..AACQDNLSAAKNQAQEFNGKVSDAQSALSDAQE.............RLKNLEDKALSQKPV-SAELQKQIAe.aKN.SV-.....-----..-----.---------..........................------------------itaqanlnta.......................
A0A1I5AWH4_9ENTR/113-274             ...................ca--MLTELLGKVNALSSDSSITSLITRLKGYTSMMNGAKEAYSSLVDQLEQQGKKW..ASASDACNQAKKEAGQLSKDVTDNQSKLKEAQQ.............TLDNLKAKAAGKNPVPSDLQNQINK...AQ.AAV.....VQA--..QTGLE.TAK------..........................------------------nnsktfidktlnpaidalnssklaldatisesn
Q2NVH6_SODGM/125-293                 ...................ma--SLTYIMGNIIKLTGNKSLQQLSNNLAAYVAQSKGTQTAASAMSEVLKQATSQW..AGCKDDLTAAQEHADQLQSAADQATQAASEALK.............SLKEL---------------QAQAAkeiAD.SGS.....VSPAL..QKKLD.AAKALSEKAdgeasraraesdkfiintlnpaisaeKSSRQNLDAISAKVSG--fi...............................
A0A1I4LK51_9RHOB/19-160              vvgpkdlpvlfrsvgrfvgka-------------------------------------KGMAREFSTAMNQAADQAgvKDVTDTFRSATDGLNKVTNPVKAATDAVKETAK.............SVTDL-NLDPESETGKLAAQRAEDAhkiQE.ATA.....KKA--..QERLD.AEAKAAEEA..........................AAEAKARADAARKATQT-td...............................
A0A0X1T887_PSEAA/79-238              ................egefv-----RLIASLIELLGNANLESLKNRLSMLRAVTQSSQQGLDRLSADYKQALGEL..VAAQGAVDTSQEQLQLLKDRLDQAQIELEAAES.............HLASLDPSSPEYADALARRDAAKAA...LG.GL-.....-QQGF..EAALK.AHLGLLATA..........................KSVAIRTEALARQVQ---aagidgkvvd.......................
Q7NUS8_CHRVO/81-233                  .....................AGKLTLLLGQLMSLLGNVSLSQLESRIATWRAMMEAQVAMGEKLSQEFQDAFKAA..SEATEALKDAVGNYDSAKQAADAAQKKADAAQA.............KVDGMSPDEPGYAEAQAASQQAA--...AD.ALQ.....AKQKA..DKAYD.AAEKARVVA..........................VEKGKVADDLAGKVQGA-n................................
A0A2X4WDD8_SALER/1-121               .....................--------------------------------MIESQKAMGLQVSKEFQAALEEA..EKATDIYEESIKKMDTAKSVYDTAAKKLTQAQN.............KLQSMDPSDPGYAKAEAAEGQAR--...KE.AKD.....AKTAF..DKAKK.AADLAGTDA..........................KTKTEQADNILTKFQGT-t................................
IPAB_SHIFL/76-231                    .....................SSQLTLLIGNLIQILGEKSLTALTNKITAWKSQQQARQQKNLEFSDKINTLLSET..EGLTRDYEKQINKLKNADSKIKDLENKINQIQT.............RLSELDPESPEKKKLSREEIQLTIK...KD.AAV.....KDRTLieQKTLS.IHSKLTDKS..........................MQLEKEIDSFSA-FSNT-a................................
#=GR IPAB_SHIFL/76-231         SS    .....................HHHHHHHHHHHHHHH-SGGGHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.............HHHCS-SS-SHHHHHHHHHHHHHHH...HH.HHH.....HHHHHHHHHHHH.HHHHHHHHH..........................HHHHHHHHCHHH-HHHH-S................................
A0A239S6G5_9BURK/83-235              ....................r-ASLTYLLGRLTELFSHSSLSDLQNRLKQSQLEAASRQAMAEQSQAEFDQAVAAA..TQAMDALDQATQHLADAEQALANAQETLTNTKA.............ALDSATPGTPEYDAAMQAYEAAKSG...YD.AAK.....ARH--..DQAKH.EATQAFEAA..........................KDATRKADDILGKFL---gnq..............................
A0A3S4I3Q7_SALBN/82-234              .....................EGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKEMGIQVSKEFQSALGEA..QEATDLYEASIKKTDTAKSVYDAAAKKLTQAQN.............KLQSLDPADPSYAQAEAAVEQAG--...KE.ATE.....AKEAL..DKAAD.ATVKAGTDA..........................KAKAEKADSILTKFQGTA.................................
A0A1N7SC18_9BURK/107-269             .....................AARLTQIVSDLMKLIGRGSLDELEKNAKLWHALSDAAKEQLENVSRAYKRAAQDA..ADAVAAAKDAADIAERARHEADAADKSAEEAKE.............QLDRAGNNHAPQAELDRLKAEWEKA...RDvAKR.....ADNTA..HAAAS.RAEAAKQQAvda...................snsaADAESA------------vdsavinaqtrl.....................
A0A2H9U8V4_9GAMM/81-233              .....................AGKLALLLGQLMVLMGEVSLSQLEGRLATWRAMMESQNAMGNQLSQELQTALEGA..EKATDAYQSALTALSTSKSALEAAEQKLTQAQV.............SLDALSPDDAGYSQALAARDQAA--...ND.RGQ.....AKQKV..DQAQA.SAELAHSQA..........................VEKGEKADKLLTQAQG--vg...............................
SIPB_SALTY/82-234                    .....................EGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKEMGIQVSKEFQTALGEA..QEATDLYEASIKKTDTAKSVYDAATKKLTQAQN.............KLQSLDPADPGYAQAEAAVEQAG--...KE.ATE.....AKEAL..DKATD.ATVKAGTDA..........................KAKAEKADNILTKFQGTA.................................
#=GR SIPB_SALTY/82-234         SS    .....................XXCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHTTTTT----STHHHHHHHH..HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.............HHTT---------CHHHHHHHHH--...HH.HHH.....HHHHH..HHHHH.HHHHHHHHH..........................HHHHHHHHTXXXXXXXXX.................................
A0A0J6RGR6_9NEIS/79-231              .....................AGKLTLLLGQLMSLLGNVSLSQLESRIATWRAMMEAQVAMGEKLSKEFQDAFKAA..SEATEALKDAVGNYDSAKQAADAAQKKADAALA.............KLNGMSPDDPGYADAQAASQQAS--...GE.AAQ.....AKQKA..DKASE.VAEKARVVA..........................VEKGKIADDLAGKVQGA-n................................
#=GC SS_cons                         .....................HHCHHHHHHHHHHHHHCHCHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHH..HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.............HHCCS-SS-SHHHCHHHHHHHHHHH...HH.HHH.....HHHHHHHHHHHH.HHHHHHHHH..........................HHHHHHHHCHHHXHHHHXS................................
#=GC seq_cons                        .......................pLThLlGpLhpLlGpsSLspLpsRlshapuhhcuppptspplSs-hppAhsps..ptAp-shcsuhpphcpspsshcsAppplspAps.............+LssLsPpsPthups.utpppAt.....t-.usp.....sppth..pcshc.uspthtppA..........................tstscph-slhsphpt..s................................
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