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Database: Pfam
Entry: T4SS_CagC
LinkDB: T4SS_CagC
Original site: T4SS_CagC 
#=GF ID   T4SS_CagC
#=GF AC   PF16943.6
#=GF DE   Cag pathogenicity island, type IV secretory system
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   HMMER:O25278-TCDB
#=GF GA   27.90 27.90;
#=GF TC   28.70 28.60;
#=GF NC   26.90 26.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   15019987
#=GF RT   Comparative analysis of the complete cag pathogenicity island
#=GF RT   sequence in four Helicobacter pylori isolates.
#=GF RA   Blomstergren A, Lundin A, Nilsson C, Engstrand L, Lundeberg J;
#=GF RL   Gene. 2004;328:85-93.
#=GF RN   [2]
#=GF RM   17942650
#=GF RT   Microevolution of Helicobacter pylori type IV secretion systems
#=GF RT   in an ulcer disease patient over a ten-year period.
#=GF RA   Alvi A, Devi SM, Ahmed I, Hussain MA, Rizwan M, Lamouliatte H,
#=GF RA   Megraud F, Ahmed N;
#=GF RL   J Clin Microbiol. 2007;45:4039-4043.
#=GF DR   INTERPRO; IPR031607;
#=GF DR   TC; 3.A.7;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   T4SS_CagC is a family of putative pathogenicity island, type IV,
#=GF CC   conjugal DNA-protein transfer, secretory system proteins from
#=GF CC   Gram-negative bacteria.
#=GF SQ   33
#=GS A0A075LPX3_9BACI/2-108   AC A0A075LPX3.1
#=GS E6LIQ6_ENTI1/9-110       AC E6LIQ6.1
#=GS A0A2R3JZ69_9LACO/5-111   AC A0A2R3JZ69.1
#=GS A0A0R1SL85_9LACO/5-111   AC A0A0R1SL85.1
#=GS X0SRN3_9BACI/12-116      AC X0SRN3.1
#=GS U5SGF7_9LACT/5-111       AC U5SGF7.1
#=GS W6N409_CLOTY/2-112       AC W6N409.1
#=GS A0A0R2L3B6_9LACO/5-111   AC A0A0R2L3B6.1
#=GS A0A2C1K463_9BACI/13-116  AC A0A2C1K463.1
#=GS K0D9D5_LEUCJ/6-114       AC K0D9D5.1
#=GS A0A0K0G9C6_9FIRM/1-90    AC A0A0K0G9C6.1
#=GS A0A1Z5IEJ4_9LACO/5-111   AC A0A1Z5IEJ4.1
#=GS A0A433RNP6_9BACL/6-112   AC A0A433RNP6.1
#=GS A0A1I6U3D2_9BACI/8-112   AC A0A1I6U3D2.1
#=GS A0A377JX76_9ENTE/7-110   AC A0A377JX76.1
#=GS A0A0R2BA24_LACCL/1-90    AC A0A0R2BA24.1
#=GS A0A447FX69_9LACO/6-114   AC A0A447FX69.1
#=GS G9ZNJ2_9LACO/5-111       AC G9ZNJ2.1
#=GS A0A0R1VNY9_9LACO/1-90    AC A0A0R1VNY9.1
#=GS Q6LWE2_LACPL/5-111       AC Q6LWE2.1
#=GS U5SCY9_9LACT/8-111       AC U5SCY9.1
#=GS A0A0D6A5F7_9LACO/5-111   AC A0A0D6A5F7.1
#=GS G9WII9_9LACT/5-111       AC G9WII9.1
#=GS A0A1I3DA45_9LACT/4-109   AC A0A1I3DA45.1
#=GS A0A447FW70_9LACO/5-111   AC A0A447FW70.1
#=GS G9WHR5_9LACT/5-111       AC G9WHR5.1
#=GS A0A150LGG2_9BACI/15-117  AC A0A150LGG2.1
#=GS A0A081BJK8_9LACO/5-111   AC A0A081BJK8.1
#=GS O25278_HELPY/6-107       AC O25278.1
#=GS A0A0D6E0D6_9LACT/5-109   AC A0A0D6E0D6.1
#=GS G8PF94_PEDCP/6-112       AC G8PF94.1
#=GS A0A0A5FZF9_9BACI/11-115  AC A0A0A5FZF9.1
#=GS A0A429ZSC7_9ENTE/7-110   AC A0A429ZSC7.1
A0A075LPX3_9BACI/2-108              ..............pyl-----KTAGVLAFTAG.LF...LivPD.ISFAESD.SSIT.KRINTGVKSIQTVLTGIVVVV....G.IVAALKIIIKHLPG....IDDPHVKNEMWKSLGG.VLLAVGAAAAVIWLLPWIYGLF-k......
E6LIQ6_ENTI1/9-110                  ...........kckles---AVVALGMLVMTNP.VV...-..--.--AATDP.---A.AKLVEAANTIKGVLTALIVVV....G.GIACAKIVIKYLPS....IDDPQEKNIMYKSLGT.ALLVTALGGALVWLVPWAYGL--la.....
A0A2R3JZ69_9LACO/5-111              .................KVKALATTGATTIYLG.LM...N..AQ.VVFAADG.GEVK.SKLTQAGKTIQGILTGLVVLV....G.ICVALFIIIKRMPD....ADDPREKSEVYHAVGR.VAGLVALAAAIIWILPWVYSLFT.......
A0A0R1SL85_9LACO/5-111              .................KVKALATTGATTIYLG.LM...N..AQ.VAFAADG.GEVK.SKLTQAGKTIQGILTGLVVLV....G.ICVALFIIIKRMPD....ADDPREKSEVYHAVGR.VAGLVALAAAIIWLLPWVYSLFT.......
X0SRN3_9BACI/12-116                 wialtilplmllalifv----------------.--...-..PD.ISLAATT.AQVQ.NKLRSGVTAIQLVLSGVVVII....A.IVAGLKIISKHLPG....IDDPHTKNEMWKSLAN.VGYAVAGAAALIWILPWVYNLF-r......
U5SGF7_9LACT/5-111                  ...........rkskvv--SAIMATGLTVMSHP.AI...-..--.-VYGASA.GQVE.AKLQNAGDIVQGILTGLVVLV....G.TVVGLFIIIKRMPA....ADNPHEKNEVYQAVGR.VAGLVALAAAIIWLLPWVYSLF-v......
W6N409_CLOTY/2-112                  .................KIKNKITKCLVSAYTA.ILvldS..TGiVSAASDA.GEVQ.SKLNQGLTTIKVVITSIIAIV....G.VIAAAKIVISKLPS....LDDPNMKNEMWRGVGM.VGAAVAAGGALTWLIPWIYALF-q......
A0A0R2L3B6_9LACO/5-111              .................KVKTLATTGATAIYLG.LM...N..AQ.VVLAADG.GEVK.SKLTSAGKTIQGILTGLVVLV....G.ICVALFIIIKRMPD....ADDPREKSEVYHAVGR.VAGLVALAAAIIWLLPWVYSLFT.......
A0A2C1K463_9BACI/13-116             .......kfvgvlafai-------------LMF.FV...A..PE.IGLAAST.GTVQ.TKIKSGVTAFQTVLTGIVVVV....G.IAASLKIIVKHLPS....IDDPHVKNEMWKSIGG.VLAAIGAAAALIWLLPWVYSLF-k......
K0D9D5_LEUCJ/6-114                  .............kski--TSILASVSTAGYLM.LT...N..AQ.IVLAADG.GEVQ.SKITNAANTIKGILTGIVVLV....G.VCVALFIIIKRLPD....ADDPREKSEVYKAVGR.VAGLVALAAAIVWILPWVYSLFT.......
A0A0K0G9C6_9FIRM/1-90               .......mnflnffils----------------.--...-..--.---AA--.-NVQ.GKINSALLTVQGVLTGIVVTV....G.VCVALFNVVTKLPN....LSDPHEKNQFWKTQGY.ILAGVAFGAAVIWLIPWAYGLFT.......
A0A1Z5IEJ4_9LACO/5-111              .................RMKALTVSSATAIYLG.LM...N..AQ.VVFAADG.GEVK.SKLTSAGKTIQGILTGLVVLV....G.ICVALFIIIKRMPD....ADDPREKSEVYHAVGR.VAGLVALAAAIIWLLPWVYSLFT.......
A0A433RNP6_9BACL/6-112              .........katslvmg-------TALAIVVCY.FI...T..PE.IVFASAG.-QVQ.AKLTNAANVVKGILTALVVLV....G.ICAALFIIIKRMPS....ADDPHEKNEVFKSVGR.VCALVALAAAIIWLLPWLYSLFT.......
A0A1I6U3D2_9BACI/8-112              ....ktskiilaigfly--------------FI.LL...-..PE.VSFAAST.SQVK.TKLNSGFTAIQGVLTGVVVVI....G.VIAAIKIFLKYMPS....LDDPHSKNEMWKSIGG.VGVAVGGAAAAVWLVPWIFSLF-q......
A0A377JX76_9ENTE/7-110              ........ntkfklesa----VIALGTLFITDP.VF...-..--.--AATD-.--PQ.AKLVQAGNTIKGVLTALIVVV....G.GIACAKIVIKYLPS....IDDPQEKNTMYKALGT.ALLVTALGGALVWLVPWAYGL--la.....
A0A0R2BA24_LACCL/1-90               .................----------------.-M...N..AQ.VVLAADG.GEVK.SKLTSAGKTIQGILTGLVVLV....G.ICVALFIIIKRMPD....ADDPREKSEVYHAVGR.VAGLVALAAAIIWLLPWVYSLFT.......
A0A447FX69_9LACO/6-114              .............kski--TSILASVSTAGYLM.LT...N..AQ.IVLAADG.SEVQ.SKITNAANTIKGILTGIVVLV....G.VCVALFIIIKRLPD....ADDPREKSEVYKAVGR.VAGLVALAAAIVWILPWVYSLFT.......
G9ZNJ2_9LACO/5-111                  .................KVKALATTGATAIYLG.LM...N..AQ.VVFAADG.GEVK.SKLTSAGKTIQGILTGLVVLV....G.ICVALFIIIKRMPD....ADDPREKSEVYHAVGR.VAGLVALAAAIIWLLPWVYSLFT.......
A0A0R1VNY9_9LACO/1-90               .................----------------.-M...A..AT.PVLAASG.SEVQ.GKISKALQTIQGILTGIVVLA....G.VCVALWIIIKRMPD....ADDPREKSEVYHAVGR.VAGLVALSAAVIWLLPWFYSLF-s......
Q6LWE2_LACPL/5-111                  .................KVKALATTGATAIYLG.LM...N..TQ.VVLAADG.GEVQ.SKLTSAGKTIQGILTGLVVLV....G.ICVALFIIIKRMPD....ADDPREKSEVYHAVGR.VAGLVALAAAVIWLLPWVYSLFT.......
U5SCY9_9LACT/8-111                  ...............ki-ISAIVATGLTVMSHP.AI...-..--.-VYGASA.GQVE.AKLQNAGDIVQGILTGLVVLV....G.TVVGLFIIIKRMPA....ADNPHEKNEVYQAVGR.VAGLVALAAAIIWLLPWVYSLF-v......
A0A0D6A5F7_9LACO/5-111              .................KVKALATTGATAIYLG.LM...N..AQ.VVFAADG.GEVK.SKLTSAGKTIQGILTGLVVLV....G.ICVALFIIIKRMPD....ADDPREKSEVYHAVGR.VAGLVALAAAIIWILPWVYSLFT.......
G9WII9_9LACT/5-111                  .................KVKVLATTGATAIYLG.LM...N..AQ.VVLAADG.GEVK.SKLTSAGKTIQGILTGLVVLV....G.ICVALFIIIKRMPD....ADDPREKSEVYHAVGR.VAGLVALAAAIIWLLPWVYSLFT.......
A0A1I3DA45_9LACT/4-109              ..........knkliqf------TVGVSALTA-.LT...Y..PT.V-AYASA.TEVQ.SRLTEAGNTIQQLLTGLIVIV....G.ICVALWIIIKRMPS....ADDPQEKSEVYKAVGR.VLGLVAIGAAIVWVVPWVYSLF-q......
A0A447FW70_9LACO/5-111              .................KMKALTVSSATAIYLG.LM...N..TQ.VVLAADG.GEVK.SKLTSAGKTIQGILTGLVVLV....G.ICVALFIIIKRMPD....ADDPREKSEVYHAVGR.VAGLVALAAAIIWLLPWVYSLFT.......
G9WHR5_9LACT/5-111                  .................KIKALATTGATAIYLG.LM...N..AQ.VVLAADG.GEVK.SKLTSAGKTIQGILTGLVVLV....G.ICVALFIIIKRMPD....ADDPREKSEVYHAVGR.VAGLVALAAAIIWLLPWVYSLFT.......
A0A150LGG2_9BACI/15-117             faliafacflyfvaphm----------------.--...-..--.-GLAAETtASVQ.TKIKKGTTGFQTVLTGIAVAV....G.IVASLKIVIKHLPG....IDDPHTKNEMWKSIGN.VILAVAAAAALIWIVPWVYALF-k......
A0A081BJK8_9LACO/5-111              .................KVKALATTGATAIYLG.LM...N..AQ.VVLAADG.GEVK.SKLTSAGKTIQGILTGLVVLV....G.ICVALFIIIKRMPD....ADDPREKSEVYHAVGR.VAGLVALAAAIIWLLPWVYSLFT.......
O25278_HELPY/6-107                  ..........ritdsyk--KVVVTLGLVVTTNP.LM...-..-A.VTSPAEG.----.---VTETKTLVIQIISVLAIV....G.GCA---LGVKGIADiwkiSDDIKRGQATVFAYAQ.PIAMLAVAGGIIYL---------stkfgfn
A0A0D6E0D6_9LACT/5-109              ...ikkakfklettvll-------------VGT.LL...V..SE.PVLAADP.---Q.GKLQDAGNTIKGILTGLIVIV....G.GIACAKIVIKYLPS....IDDPQEKNIMWKSITT.ALGVTALGGSLVWLVPWAYGLF-a......
G8PF94_PEDCP/6-112                  .................KMKALATTGATAIYLG.LM...N..AQ.VVLAAGG.GEVK.SKLTQAGKTIQGILTGLVVLV....G.ICVALFIIIKRMPD....ADDPREKSEVYHAVGR.VAGLVALAAAIIWILPWVYSLFT.......
A0A0A5FZF9_9BACI/11-115             .......fkvvllmsfa------------ALLL.LI...T..PD.FALAAST.SQVQ.SKLNQGAKAIQLVLTSLVVVM....G.IIAAIKIVVKHLPS....IDDAHVKNEMWKGIGQ.VFAGVIAGAALVWIIPWAYSLF-v......
A0A429ZSC7_9ENTE/7-110              ...........dtkfkl--------GSAVVALGtLF...I..TD.LVFAATD.--PQ.AKLVQAGNTIKGVLTALIVVV....G.GIACAKIVIKYLPS....IDDPQEKNTMYKALGT.ALLVTALGGALVWLVPWAYGL--la.....
#=GC seq_cons                       .....................hhs.uhsshhhs.Lh...s..sp.lVhAA-u.upVp.oKLssAupTIQGILTGLVVlV....G.ICVALaIIIKRhPs....ADDP+EKsEVY+AVGR.VuGLVALAAAlIWLLPWVYSLF........
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