GenomeNet

Database: Pfam
Entry: TAD2
LinkDB: TAD2
Original site: TAD2 
#=GF ID   TAD2
#=GF AC   PF18521.2
#=GF DE   Transactivation domain 2
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF05701
#=GF GA   31.00 31.00;
#=GF TC   31.40 31.00;
#=GF NC   30.70 30.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   25753752
#=GF RT   Characterization of the p300 Taz2-p53 TAD2 complex and
#=GF RT   comparison with the p300 Taz2-p53 TAD1 complex.
#=GF RA   Miller Jenkins LM, Feng H, Durell SR, Tagad HD, Mazur SJ, Tropea
#=GF RA   JE, Bai Y, Appella E;
#=GF RL   Biochemistry. 2015;54:2001-2010.
#=GF RN   [2]
#=GF RM   16234232
#=GF RT   Single-stranded DNA mimicry in the p53 transactivation domain
#=GF RT   interaction with replication protein A.
#=GF RA   Bochkareva E, Kaustov L, Ayed A, Yi GS, Lu Y, Pineda-Lucena A,
#=GF RA   Liao JC, Okorokov AL, Milner J, Arrowsmith CH, Bochkarev A;
#=GF RL   Proc Natl Acad Sci U S A. 2005;102:15412-15417.
#=GF RN   [3]
#=GF RM   16793543
#=GF RT   Structure of the Tfb1/p53 complex: Insights into the interaction
#=GF RT   between the p62/Tfb1 subunit of TFIIH and the activation domain
#=GF RT   of p53.
#=GF RA   Di Lello P, Jenkins LM, Jones TN, Nguyen BD, Hara T, Yamaguchi
#=GF RA   H, Dikeakos JD, Appella E, Legault P, Omichinski JG;
#=GF RL   Mol Cell. 2006;22:731-740.
#=GF RN   [4]
#=GF RM   20961098
#=GF RT   Structure of the p53 transactivation domain in complex with the
#=GF RT   nuclear receptor  coactivator binding domain of CREB binding
#=GF RT   protein.
#=GF RA   Lee CW, Martinez-Yamout MA, Dyson HJ, Wright PE;
#=GF RL   Biochemistry. 2010;49:9964-9971.
#=GF RN   [5]
#=GF RM   23063560
#=GF RT   HMGB1-facilitated p53 DNA binding occurs via HMG-Box/p53
#=GF RT   transactivation domain interaction, regulated by the acidic
#=GF RT   tail.
#=GF RA   Rowell JP, Simpson KL, Stott K, Watson M, Thomas JO;
#=GF RL   Structure. 2012;20:2014-2024.
#=GF RN   [6]
#=GF RM   25216154
#=GF RT   Extended string binding mode of the phosphorylated
#=GF RT   transactivation domain of tumor suppressor p53.
#=GF RA   Okuda M, Nishimura Y;
#=GF RL   J Am Chem Soc. 2014;136:14143-14152.
#=GF DR   INTERPRO; IPR040926;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a N-terminal transactivation domain (TAD) domain 2 found
#=GF CC   in p53 proteins. In p53 two TAD domains are found termed TAD1
#=GF CC   (residues 1-39) and TAD2 (residues 40-61), both of which have
#=GF CC   been shown to be able to independently activate gene
#=GF CC   transcription and are intrinsically disordered protein domains
#=GF CC   that adopt a helical conformation for at least part of their
#=GF CC   length when bound. This inherent flexibility allows the TADs to
#=GF CC   adapt to and bind a broad range of proteins. This entry
#=GF CC   describes TAD2 which can independently interact with Taz2 domain
#=GF CC   of the histone acetyltransferase p300 [1]. It has also been
#=GF CC   shown to bind to OB-fold domain of replication protein 70 A
#=GF CC   (RPA) [2] as well as the pleckstrin homology (PH) domain of the
#=GF CC   p62 and Tfb1 subunits of human and yeast TFIIH [3].
#=GF SQ   84
#=GS A0A2I2Y7Z8_GORGO/1-20   AC A0A2I2Y7Z8.1
#=GS A0A2R9A5Q0_PANPA/35-59  AC A0A2R9A5Q0.1
#=GS A0A2I2YW09_GORGO/30-54  AC A0A2I2YW09.1
#=GS A0A2K6QDJ5_RHIRO/35-59  AC A0A2K6QDJ5.1
#=GS G1RF61_NOMLE/35-59      AC G1RF61.2
#=GS A0A2K5JJ56_COLAP/35-59  AC A0A2K5JJ56.1
#=GS A0A2K5JJ89_COLAP/35-59  AC A0A2K5JJ89.1
#=GS A0A1D5Q594_MACMU/44-68  AC A0A1D5Q594.1
#=GS A0A2K6QDJ2_RHIRO/35-59  AC A0A2K6QDJ2.1
#=GS A0A2K5N3J8_CERAT/35-59  AC A0A2K5N3J8.1
#=GS A0A2I2YTF6_GORGO/35-59  AC A0A2I2YTF6.1
#=GS A0A2K6QDH6_RHIRO/35-59  AC A0A2K6QDH6.1
#=GS A0A2I3T303_PANTR/35-59  AC A0A2I3T303.1
#=GS A0A2K6QDJ3_RHIRO/35-59  AC A0A2K6QDJ3.1
#=GS A0A2R9A5P4_PANPA/35-59  AC A0A2R9A5P4.1
#=GS A0A2I3GF05_NOMLE/35-59  AC A0A2I3GF05.1
#=GS P53_HUMAN/35-59         AC P04637.4
#=GS P53_HUMAN/35-59         DR PDB; 2K8F B; 35-39;
#=GS P53_HUMAN/35-59         DR PDB; 5HOU A; 1035-1059;
#=GS P53_HUMAN/35-59         DR PDB; 2MZD B; 1-25;
#=GS P53_HUMAN/35-59         DR PDB; 2B3G B; 35-56;
#=GS P53_HUMAN/35-59         DR PDB; 5HP0 A; 3037-3059;
#=GS P53_HUMAN/35-59         DR PDB; 2GS0 B; 45-58;
#=GS P53_HUMAN/35-59         DR PDB; 2LY4 B; 35-59;
#=GS P53_HUMAN/35-59         DR PDB; 5HPD A; 3035-3059;
#=GS P53_HUMAN/35-59         DR PDB; 2RUK A; 41-59;
#=GS P53_HUMAN/35-59         DR PDB; 2L14 B; 35-59;
#=GS A0A2K6LYM5_RHIBE/35-59  AC A0A2K6LYM5.1
#=GS A0A2K6AAI4_MANLE/35-59  AC A0A2K6AAI4.1
#=GS A0A1I7Q490_MACMU/44-68  AC A0A1I7Q490.1
#=GS A0A2K6QDJ8_RHIRO/35-59  AC A0A2K6QDJ8.1
#=GS A0A2I3HA34_NOMLE/35-59  AC A0A2I3HA34.1
#=GS A0A2I3T645_PANTR/35-59  AC A0A2I3T645.1
#=GS A0A2I3NCU7_PAPAN/35-59  AC A0A2I3NCU7.1
#=GS A0A2K6D4N4_MACNE/44-68  AC A0A2K6D4N4.1
#=GS A0A2I3T5N8_PANTR/35-59  AC A0A2I3T5N8.1
#=GS A0A2K5N3I9_CERAT/35-59  AC A0A2K5N3I9.1
#=GS A0A2I2ZNQ9_GORGO/35-59  AC A0A2I2ZNQ9.1
#=GS A0A2R9A198_PANPA/1-20   AC A0A2R9A198.1
#=GS A0A2K5WN49_MACFA/35-59  AC A0A2K5WN49.1
#=GS A0A2I3MCI3_PAPAN/44-68  AC A0A2I3MCI3.1
#=GS A0A2I3GX68_NOMLE/35-59  AC A0A2I3GX68.1
#=GS A0A2K5JJ67_COLAP/35-59  AC A0A2K5JJ67.1
#=GS A0A2K6LYP2_RHIBE/35-59  AC A0A2K6LYP2.1
#=GS A0A2K5F3V2_AOTNA/36-59  AC A0A2K5F3V2.1
#=GS A0A2K6LYM9_RHIBE/35-59  AC A0A2K6LYM9.1
#=GS A0A2K6LYN1_RHIBE/35-59  AC A0A2K6LYN1.1
#=GS A0A2K6QDI6_RHIRO/35-59  AC A0A2K6QDI6.1
#=GS A0A2I3HEB4_NOMLE/35-59  AC A0A2I3HEB4.1
#=GS A0A2I3LC67_PAPAN/35-59  AC A0A2I3LC67.1
#=GS A0A096P2R8_PAPAN/35-59  AC A0A096P2R8.1
#=GS A0A2K5N3F4_CERAT/35-59  AC A0A2K5N3F4.1
#=GS F7F8L3_MACMU/35-59      AC F7F8L3.1
#=GS A0A2K6AAJ8_MANLE/35-59  AC A0A2K6AAJ8.1
#=GS E9PCY9_HUMAN/35-59      AC E9PCY9.8
#=GS A0A2K5N3Z0_CERAT/44-68  AC A0A2K5N3Z0.1
#=GS G3R2U9_GORGO/35-59      AC G3R2U9.1
#=GS A0A1D5RL03_MACMU/35-59  AC A0A1D5RL03.1
#=GS A0A087WZU8_HUMAN/35-59  AC A0A087WZU8.1
#=GS A0A2K5JJ94_COLAP/38-62  AC A0A2K5JJ94.1
#=GS A0A2R9A2G9_PANPA/35-59  AC A0A2R9A2G9.1
#=GS A0A2K5DXG0_AOTNA/34-60  AC A0A2K5DXG0.1
#=GS E7EQX7_HUMAN/35-59      AC E7EQX7.1
#=GS A0A2I2ZK26_GORGO/35-59  AC A0A2I2ZK26.1
#=GS A0A0D9RG12_CHLSB/35-59  AC A0A0D9RG12.1
#=GS A0A2K5N3M9_CERAT/35-59  AC A0A2K5N3M9.1
#=GS P53_MACMU/35-59         AC P56424.1
#=GS A0A2I3N9A3_PAPAN/35-59  AC A0A2I3N9A3.1
#=GS A0A2K5WN47_MACFA/33-57  AC A0A2K5WN47.1
#=GS A0A2K5DGQ7_AOTNA/29-54  AC A0A2K5DGQ7.1
#=GS S4R334_HUMAN/35-59      AC S4R334.1
#=GS A0A2K6AAN3_MANLE/35-59  AC A0A2K6AAN3.1
#=GS A0A2K6AAQ3_MANLE/35-59  AC A0A2K6AAQ3.1
#=GS A0A2K6LYR5_RHIBE/35-59  AC A0A2K6LYR5.1
#=GS A0A2K6LYQ1_RHIBE/35-59  AC A0A2K6LYQ1.1
#=GS A0A2K5WMM5_MACFA/35-59  AC A0A2K5WMM5.1
#=GS A0A2I3MD32_PAPAN/35-59  AC A0A2I3MD32.1
#=GS A0A2I3SYN1_PANTR/35-59  AC A0A2I3SYN1.1
#=GS A0A2K5JJA8_COLAP/35-59  AC A0A2K5JJA8.1
#=GS A0A2K6QDI9_RHIRO/35-59  AC A0A2K6QDI9.1
#=GS J3KP33_HUMAN/35-59      AC J3KP33.1
#=GS A0A2K6LYM8_RHIBE/35-59  AC A0A2K6LYM8.1
#=GS A0A0U1RQC9_HUMAN/1-20   AC A0A0U1RQC9.1
#=GS A0A2R9A5M5_PANPA/35-59  AC A0A2R9A5M5.1
#=GS A0A2K5JJ46_COLAP/35-59  AC A0A2K5JJ46.1
#=GS A0A2K5WMY7_MACFA/35-59  AC A0A2K5WMY7.1
#=GS P53_MACFA/35-59         AC P56423.2
#=GS E7EMR6_HUMAN/35-59      AC E7EMR6.1
#=GS A0A2I2ZTB3_GORGO/35-59  AC A0A2I2ZTB3.1
#=GS A0A2I3S1V8_PANTR/30-54  AC A0A2I3S1V8.1
#=GS A0A2K6AAH4_MANLE/35-59  AC A0A2K6AAH4.1
#=GS H2NSL2_PONAB/35-59      AC H2NSL2.1
#=GS A0A2K6AAI9_MANLE/44-68  AC A0A2K6AAI9.1
#=GS H2QC53_PANTR/35-59      AC H2QC53.1
A0A2I2Y7Z8_GORGO/1-20              .-----MDDLMLSPDDI..EQWFTEDPG.
A0A2R9A5Q0_PANPA/35-59             .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2I2YW09_GORGO/30-54             .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2K6QDJ5_RHIRO/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
G1RF61_NOMLE/35-59                 .LPSQAMDDLMLSPEDI..AQWFTEDPG.
A0A2K5JJ56_COLAP/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K5JJ89_COLAP/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A1D5Q594_MACMU/44-68             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K6QDJ2_RHIRO/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K5N3J8_CERAT/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2I2YTF6_GORGO/35-59             .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2K6QDH6_RHIRO/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2I3T303_PANTR/35-59             .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2K6QDJ3_RHIRO/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2R9A5P4_PANPA/35-59             .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2I3GF05_NOMLE/35-59             .LPSQAMDDLMLSPEDI..AQWFTEDPG.
P53_HUMAN/35-59                    .LPSQAMDDLMLSPDDI..EQWFTEDPG.
#=GR P53_HUMAN/35-59         SS    .SCSCTTCGGSSGHHHH..HHHHCS-SS.
A0A2K6LYM5_RHIBE/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K6AAI4_MANLE/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A1I7Q490_MACMU/44-68             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K6QDJ8_RHIRO/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2I3HA34_NOMLE/35-59             .LPSQAMDDLMLSPEDI..AQWFTEDPG.
A0A2I3T645_PANTR/35-59             .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2I3NCU7_PAPAN/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K6D4N4_MACNE/44-68             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2I3T5N8_PANTR/35-59             .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2K5N3I9_CERAT/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2I2ZNQ9_GORGO/35-59             .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2R9A198_PANPA/1-20              .-----MDDLMLSPDDI..EQWFTEDPG.
A0A2K5WN49_MACFA/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2I3MCI3_PAPAN/44-68             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2I3GX68_NOMLE/35-59             .LPSQAMDDLMLSPEDI..AQWFTEDPG.
A0A2K5JJ67_COLAP/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K6LYP2_RHIBE/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K5F3V2_AOTNA/36-59             l--SQPMDDLMLSLDDI..AQWFSHGP-v
A0A2K6LYM9_RHIBE/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K6LYN1_RHIBE/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K6QDI6_RHIRO/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2I3HEB4_NOMLE/35-59             .LPSQAMDDLMLSPEDI..AQWFTEDPG.
A0A2I3LC67_PAPAN/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A096P2R8_PAPAN/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K5N3F4_CERAT/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
F7F8L3_MACMU/35-59                 .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K6AAJ8_MANLE/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
E9PCY9_HUMAN/35-59                 .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2K5N3Z0_CERAT/44-68             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
G3R2U9_GORGO/35-59                 .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A1D5RL03_MACMU/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A087WZU8_HUMAN/35-59             .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2K5JJ94_COLAP/38-62             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2R9A2G9_PANPA/35-59             .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2K5DXG0_AOTNA/34-60             l-LSQLVDDLMLSPDDIyiAQWFSQDP-v
E7EQX7_HUMAN/35-59                 .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2I2ZK26_GORGO/35-59             .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A0D9RG12_CHLSB/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K5N3M9_CERAT/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
P53_MACMU/35-59                    .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2I3N9A3_PAPAN/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K5WN47_MACFA/33-57             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K5DGQ7_AOTNA/29-54             l--SQPVDDLMLSPDDIyiAQWFSQDP-v
S4R334_HUMAN/35-59                 .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2K6AAN3_MANLE/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K6AAQ3_MANLE/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K6LYR5_RHIBE/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K6LYQ1_RHIBE/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K5WMM5_MACFA/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2I3MD32_PAPAN/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2I3SYN1_PANTR/35-59             .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2K5JJA8_COLAP/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K6QDI9_RHIRO/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
J3KP33_HUMAN/35-59                 .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2K6LYM8_RHIBE/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A0U1RQC9_HUMAN/1-20              .-----MDDLMLSPDDI..EQWFTEDPG.
A0A2R9A5M5_PANPA/35-59             .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2K5JJ46_COLAP/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
A0A2K5WMY7_MACFA/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
P53_MACFA/35-59                    .LPSQAVDDLMLSPDDL..AQWLTEDPG.
E7EMR6_HUMAN/35-59                 .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2I2ZTB3_GORGO/35-59             .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2I3S1V8_PANTR/30-54             .LPSQAMDDLMLSPDDI..EQWFTEDPG.
A0A2K6AAH4_MANLE/35-59             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
H2NSL2_PONAB/35-59                 .LPSQAVDDLLLSPDDI..AQWFIEDPG.
A0A2K6AAI9_MANLE/44-68             .LPSQAVDDLMLSPDDL..AQWLTEDPG.
H2QC53_PANTR/35-59                 .LPSQAMDDLMLSPDDI..EQWFTEDPG.
#=GC SS_cons                       .SCSCTTCGGSSGHHHH..HHHHCS-SS.
#=GC seq_cons                      .LPSQAVDDLMLSPDDl..AQWhTEDPG.
//
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