#=GF ID   THP2
#=GF AC   PF09432.11
#=GF DE   Tho complex subunit THP2
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Wood V;0000-0001-6330-7526
#=GF SE   manual
#=GF GA   28.00 28.00;
#=GF TC   30.40 88.60;
#=GF NC   27.90 22.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11060033
#=GF RT   A protein complex containing Tho2, Hpr1, Mft1 and a novel
#=GF RT   protein, Thp2, connects transcription elongation with mitotic
#=GF RT   recombination in Saccharomyces cerevisiae. 
#=GF RA   Chavez S, Beilharz T, Rondon AG, Erdjument-Bromage H, Tempst P,
#=GF RA   Svejstrup JQ, Lithgow T, Aguilera A; 
#=GF RL   EMBO J. 2000;19:5824-5834.
#=GF RN   [2]
#=GF RM   12093753
#=GF RT   The yeast THO complex and mRNA export factors link RNA
#=GF RT   metabolism with transcription and genome instability. 
#=GF RA   Jimeno S, Rondon AG, Luna R, Aguilera A; 
#=GF RL   EMBO J. 2002;21:3526-3535.
#=GF DR   INTERPRO; IPR018557;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The THO complex plays a role in coupling transcription
#=GF CC   elongation to mRNA export.  It is composed of subunits THP2,
#=GF CC   HPR1, THO2 and MFT1 [1].
#=GF SQ   25
#=GS G0VDT0_NAUCC/118-246      AC G0VDT0.1
#=GS A0A0C7N7V1_9SACH/121-248  AC A0A0C7N7V1.1
#=GS I6NCT5_ERECY/120-250      AC I6NCT5.1
#=GS G0W885_NAUDC/117-245      AC G0W885.1
#=GS I2GZR0_TETBL/114-242      AC I2GZR0.1
#=GS Q6CXV8_KLULA/119-249      AC Q6CXV8.2
#=GS Q75D17_ASHGO/119-247      AC Q75D17.2
#=GS A7TEX7_VANPO/115-244      AC A7TEX7.1
#=GS C5E1Y6_LACTC/120-243      AC C5E1Y6.1
#=GS J4U4S3_SACK1/115-243      AC J4U4S3.1
#=GS G8BNX6_TETPH/133-261      AC G8BNX6.1
#=GS W0T571_KLUMD/122-252      AC W0T571.1
#=GS THP2_YEAST/115-243        AC O13539.1
#=GS A0A1G4JI36_9SACH/121-251  AC A0A1G4JI36.1
#=GS S6E1D2_ZYGB2/116-244      AC S6E1D2.1
#=GS C5DTV5_ZYGRC/116-244      AC C5DTV5.1
#=GS A0A1G4MJ07_LACFM/120-248  AC A0A1G4MJ07.1
#=GS A0A0X8HTE9_9SACH/120-250  AC A0A0X8HTE9.1
#=GS A0A1G4IRN9_9SACH/121-245  AC A0A1G4IRN9.1
#=GS A0A1G4JP12_9SACH/121-247  AC A0A1G4JP12.1
#=GS H2AVH8_KAZAF/115-243      AC H2AVH8.1
#=GS A0A1X7R5N4_9SACH/118-247  AC A0A1X7R5N4.1
#=GS Q6FQZ2_CANGA/122-250      AC Q6FQZ2.1
#=GS J7RYT2_KAZNA/124-252      AC J7RYT2.1
#=GS G8ZYI7_TORDC/112-240      AC G8ZYI7.1
G0VDT0_NAUCC/118-246                 .LEYVNLLERLSVDLAKQVEISDPSVSK.FVLNDWNPPKGVQAILDKFAD....PSADAALLKMELVHYLDDIKMSRAKYSLENKYSLQDKVVNLNTELNRWRKELDDIEMMMFGDGATSIKKMLANVESLRSKI..
A0A0C7N7V1_9SACH/121-248             .MEHINLVGRLSSKLCDPALASRS----.-AAGDRDDAFDLKQILEAYNSlgdeDVEDTANLKLQLLRWTDSMKMENARFTLENQHILRDKLKSITAEVTQWKKNYESVENTMFGEDPHSIMQTIQRIQKMKPQL..
I6NCT5_ERECY/120-250                 .LKHLKLLNALAVDMCYPLVNQEDTEN-.IAVNKEHYPRELAPVLEEYDAy.gaDIEDIRNLRSKLMQYFENIKSSRAKYLLENKYLLADSLKELTKLVAAWSQKWEHLENILFGDSPASLRKLLQTMETVKASL..
G0W885_NAUDC/117-245                 .LEYINLLQRLSVDLVRQIEISDPNVSK.INVDGWNPPKKIQVLLDKFGE....PDADTRELKIQVQRYLDDIKMSRAKYSLENKYSLQEKLSEVTKAVNQWRAEWDNIEMMLFGDGSNSMKNMLANVESIKSKL..
I2GZR0_TETBL/114-242                 q-KYINMVNRLSVDLAKQIETADIRKDK.YIVDNWLPPKEIEEILQEFTD....DDSEAVRLRARLEQYLDQLKMERVKYTLENRYTIEDKLILANKEVNRWRIEWDKLETLMFGRGPNSLKNMLQKNEQLAEKL..
Q6CXV8_KLULA/119-249                 .MRHLSLVANLSDDLVHKLESSDESNK-.VLVNKNPLPAVLKETVKQYEEi.gdEQQRIENIRAKLFQYLDEIKAGRAKYALENKYILNSTLQQITKEVSEWSQRWTHIENSLFGDSPTSLKKLVQKAENIKEL-l.
Q75D17_ASHGO/119-247                 .LQHLQLVNQLSVELAYPLGRRGSEH--.VTVNREGPPPELVAALAAYDAg..pDAPAAAELRAELLRYLDDIKATRARYLLENKYLLADSLRQLTRDVSSWSQKWESLEGTLFGDAPSSLRSLLRSVDTTKATI..
A7TEX7_VANPO/115-244                 .LVYINLLERLASDLFIQVEDAQFKDNEvIMVDEVAAPVEVQDVLKKYIT....ESSETSVLRDELDKYLNEIKMERAELTIKNKFSLQPTLNELSKEVNYWRKEWDNMEMLMFGDGPNSMKRMMKNIESLRAK-a.
C5E1Y6_LACTC/120-243                 .LEHINLIGRLSSVLTEMLP--------.SELDDSTQNLELAQILEAYNTd.skGSEDTDCLKEKLLDWIDSIKMEKARYSLENQHILRDSLKALTMEVTRWRENYESIEGMMFGENANSISQMLHKVQRLRPQL..
J4U4S3_SACK1/115-243                 .LKYINLLKRLSVDLAKQVEVSDPSVTV.YELDNWVPSEKLQGILEEYCA....PETDIRGVDAQIKNYLGQIKMARAKFGLENKYSLKEGLSTLTKELNHWRKEWDDIEMLMFGDDAHSMKKMIQKIDSLKSEI..
G8BNX6_TETPH/133-261                 .MIYTNLLGRLSVGLIQQVQVSNTENSE.IMINDYPPPEEIVSILEKFNT....ETTETDDLRGQLDDYLQKIKMDRAKYTLENEYLLKDSLLTLSKEVNYWRKEYDNLEMLMFSDGPNTIMKMMKNVDSLRLKV..
W0T571_KLUMD/122-252                 .MRHLSLISNLSDDLVVKLESHDDSNL-.VVTNKDPLPPVLKNTIRKYEEl.gpEQQHIEDIRAALFQYLDDIKAGRAKYALENKYILNTSLQEITKEVSEWSQRWTNIENTLFGDSPNSLKKLIQKADEIKEL-l.
THP2_YEAST/115-243                   .LRYINLLKRLSVDLAKQVEVSDPSVTV.YEMDKWVPSEKLQGILEQYCA....PDTDIRGVDAQIKNYLDQIKMARAKFGLENKYSLKERLSTLTKELNHWRKEWDDIEMLMFGDDAHSMKKMIQKIDSLKSEI..
A0A1G4JI36_9SACH/121-251             f-EHQSLLGRLSASLDLSESANERSV-R.PAKDDDATKNVFHQLLKQYSAt.nsSQDELTKLRDQLMELINDQKLEKAQYSLENQHTLKEVFSQLAHQVTEWKEQFQSLEDIMFGNGPRSMLSLFHEVDKMKP--ll
S6E1D2_ZYGB2/116-244                 .LDYINLLQRLSVDLAKQIEISDREKSA.FEVNSWEPTDRMQTIVEQLAD....PNVDSALLNSQLVEYMDQIKMERAKYTIENKHSLQETLVELNKEVNYWRRNWNAIENLMFGDNSHSIKRMLHSIEILRSKL..
C5DTV5_ZYGRC/116-244                 .LDYVNLLQRLSVDLAKQIEISDPEVSE.FVVDNWSPPDGMQSILEQLAN....PDKDSTHLQSQLDQYLDQIKMERAKYTIENKYSLQETLNEVNKEVNYWRRNWNAIENLMFGDSAHSIKKMLQSIDLLRAKL..
A0A1G4MJ07_LACFM/120-248             .LEHGNLLGRLSSNLGNQMK-QDIDTS-.ISVEV-SKRDTLREIMAKYDSi.dgNDDQPEILRQELLDYIDSMKMEKARYSLVNQYMLSDSYKQLTKEVTQWKHQYESLEGIMFGDNPNSIRSMVYKIESLKEKL..
A0A0X8HTE9_9SACH/120-250             .MKHLKLLNDFSTDMSFPIANQEGTD-H.IVVNREHFPAELLPVLERYDQh.geAVDDTMKLRSEMMQYFENIRSTRAKYHLENKYLIATSLKELTKSVAAWSSKWENLESLLFGDNPNSIRKLLQSVQSIKASI..
A0A1G4IRN9_9SACH/121-245             .LEHTNLIGRLSSNLCDAASAF------.SQVEKED-YFDLESWLQSYKSe.daSVETREILKSRLVSWITSIKMEKARYLVENQHILRDMLKSLTSDVAQWRTNYESIESMLFGDAHNSIAKTLLDITNLRQEL..
A0A1G4JP12_9SACH/121-247             .MEHVNLIGRLSSKFSDSAVSSSKDSS-.----NTGAEFDLEKVLDAYEAe.nsSPQDTEQLKRRLLDWIDSLKMNKARYSLENQYILRDMLKKLTSDVMQWRQNYESVENMMFGGTQNSIVQTLQKIEKLRPS-l.
H2AVH8_KAZAF/115-243                 h-EYVNLLERLSVDLGKQVDISDSNVTE.LVVDDWTPPSELISLLEQYNE....SSSDIELQDSKVDRYLDQLKLLRAKYAMENNYLLKSTLNDLNDEVNYWRREYENIESMMFGNGPNSMKKMLHNVEVLKVK-a.
A0A1X7R5N4_9SACH/118-247             .LEYINLLNRLSVELVKQVDISDPDISE.FVFDNWKPPAELQKIIDNYYG...dENKNFTSLNGDLQDYFNSIKLSRAKYTLENRYVLQRHLTELNKEANYWRGELDNIELLLFGEGPHSIRKVLQNVEVLKNKL..
Q6FQZ2_CANGA/122-250                 .LTYINLLTKLSVNLAKQIEFADHSVSE.FLLEDWKPPHELQSILEKFVD....MEEDPEVLNDQLNKYMDNIKMERAKYSLENKYSLQEQLKTLESELSRWRDAWVNIESLMFGDSPNSMKGMLQNIESMKKEL..
J7RYT2_KAZNA/124-252                 .LEYLNLLGTYAVDLARQIEISDPSVSH.FDIDDWKPPRKLLEILDKFQS....EDCEPIKIRDELQSYLDNIKLSRAKFTLENKHILQDKLGVLSKEVSYWRKEWDNIENMMFGEGSDSMRSMLQTVDSLRSKI..
G8ZYI7_TORDC/112-240                 .LRYVNLLERLSVDLVKEIEIADPTVTE.FVVNKWNPPKGIFEILDELAD....PATDVVAVRSRLNGYLDRIKMERAKYTIENKHSLQGTLRDLNKEVSNWRKEWDSIENVMFGDGSHSMKKMLQNIDSLKSKL..
#=GC seq_cons                        .LcalNLLsRLSVDLscpl-huDssss..hhlschssPpcLpslL-pYss....sss-sppL+ucLhpYlDsIKMpRAKYoLENKYhLp-sLppLoKEVspWRccW-sIEshMFGDussSl++MLpsl-sLKscl..
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