GenomeNet

Database: Pfam
Entry: TRH
LinkDB: TRH
Original site: TRH 
#=GF ID   TRH
#=GF AC   PF05438.12
#=GF DE   Thyrotropin-releasing hormone (TRH)
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_14384 (release 8.0)
#=GF GA   27.80 27.80;
#=GF TC   31.00 28.10;
#=GF NC   25.70 23.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Thyrotropin-releasing_hormone
#=GF RN   [1]
#=GF RM   10526628
#=GF RT   Thyrotropin-releasing hormone (TRH), a signal peptide of the
#=GF RT   central nervous system. 
#=GF RA   Heuer H, Schafer MK, Bauer K; 
#=GF RL   Acta Med Austriaca 1999;26:119-122.
#=GF RN   [2]
#=GF RM   12467901
#=GF RT   Neuroprotective effect and brain receptor binding of taltirelin,
#=GF RT   a novel thyrotropin-releasing hormone (TRH) analogue, in
#=GF RT   transient forebrain ischemia of C57BL/6J mice. 
#=GF RA   Urayama A, Yamada S, Kimura R, Zhang J, Watanabe Y; 
#=GF RL   Life Sci 2002;72:601-607.
#=GF DR   INTERPRO; IPR008857;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several thyrotropin-releasing hormone
#=GF CC   (TRH) proteins. Thyrotropin-Releasing Hormone (TRH;
#=GF CC   pyroGlu-His-Pro-NH2), originally isolated as a hypothalamic
#=GF CC   neuropeptide hormone, most likely acts also as a neuromodulator
#=GF CC   and/or neurotransmitter in the central nervous system (CNS).
#=GF CC   This interpretation is supported by the identification of a
#=GF CC   peptidase localised on the surface of neuronal cells which has
#=GF CC   been termed TRH-degrading ectoenzyme (TRH-DE) since it
#=GF CC   selectively inactivates TRH [1]. TRH has been used clinically
#=GF CC   for the treatment of spinocerebellar degeneration and
#=GF CC   disturbance of consciousness in humans [2].
#=GF SQ   138
#=GS A0A1U8BQT8_MESAU/127-172  AC A0A1U8BQT8.1
#=GS H2TW66_TAKRU/6-81         AC H2TW66.1
#=GS H2P9C6_PONAB/6-206        AC H2P9C6.1
#=GS D6RFM1_HUMAN/6-202        AC D6RFM1.1
#=GS F7HLL6_CALJA/89-178       AC F7HLL6.1
#=GS G3TEL3_LOXAF/5-91         AC G3TEL3.1
#=GS A0A151MK38_ALLMI/41-262   AC A0A151MK38.1
#=GS F1QKW8_DANRE/3-96         AC F1QKW8.1
#=GS A0A0Q3URX9_AMAAE/84-304   AC A0A0Q3URX9.1
#=GS K7FNZ1_PELSI/6-205        AC K7FNZ1.1
#=GS K7E2N6_MONDO/6-157        AC K7E2N6.1
#=GS A0A093FXE0_GAVST/7-227    AC A0A093FXE0.1
#=GS A0A093ITK7_DRYPU/7-223    AC A0A093ITK7.1
#=GS M3Z0M6_MUSPF/10-211       AC M3Z0M6.1
#=GS I3NCI2_ICTTR/6-204        AC I3NCI2.1
#=GS L9JDC1_TUPCH/126-198      AC L9JDC1.1
#=GS A0A226MKF2_CALSU/22-239   AC A0A226MKF2.1
#=GS A0A091U5R6_PHALP/8-227    AC A0A091U5R6.1
#=GS A0A091QB96_MERNU/7-227    AC A0A091QB96.1
#=GS A0A093ILQ3_FULGA/7-227    AC A0A093ILQ3.1
#=GS A0A099YTJ5_TINGU/7-226    AC A0A099YTJ5.1
#=GS G3WTB0_SARHA/6-156        AC G3WTB0.1
#=GS W5MZE0_LEPOC/6-119        AC W5MZE0.1
#=GS A0A2I2UZ94_FELCA/6-202    AC A0A2I2UZ94.1
#=GS TRH_MOUSE/140-224         AC Q62361.2
#=GS S7PNX2_MYOBR/6-207        AC S7PNX2.1
#=GS A0A2G8L3S2_STIJA/164-319  AC A0A2G8L3S2.1
#=GS G3R1J0_GORGO/4-197        AC G3R1J0.2
#=GS A0A087QJF5_APTFO/7-227    AC A0A087QJF5.1
#=GS A0A1A6HWM7_NEOLE/6-216    AC A0A1A6HWM7.1
#=GS F7HLL2_CALJA/6-207        AC F7HLL2.1
#=GS A0A0P7X5Y1_9TELE/5-216    AC A0A0P7X5Y1.1
#=GS A0A2I4BUQ6_9TELE/6-233    AC A0A2I4BUQ6.1
#=GS W5PU12_SHEEP/45-246       AC W5PU12.1
#=GS A0A093HSA7_STRCA/7-227    AC A0A093HSA7.1
#=GS A0A1U8BQT8_MESAU/6-125    AC A0A1U8BQT8.1
#=GS W5MZE8_LEPOC/6-228        AC W5MZE8.1
#=GS L5M7T1_MYODS/6-207        AC L5M7T1.1
#=GS Q4RJV2_TETNG/1-226        AC Q4RJV2.1
#=GS A0A093TKE2_PHACA/7-227    AC A0A093TKE2.1
#=GS A0A1V4JIY5_PATFA/7-225    AC A0A1V4JIY5.1
#=GS D2HGM5_AILME/6-207        AC D2HGM5.1
#=GS C3ZWL4_BRAFL/145-309      AC C3ZWL4.1
#=GS E2RHA2_CANLF/6-205        AC E2RHA2.1
#=GS A0A091GN18_BUCRH/7-227    AC A0A091GN18.1
#=GS A0A2I2U1H2_FELCA/34-230   AC A0A2I2U1H2.1
#=GS F7B653_HORSE/6-206        AC F7B653.1
#=GS U3KGX4_FICAL/7-224        AC U3KGX4.1
#=GS F7AY27_XENTR/6-214        AC F7AY27.1
#=GS A0A093GNR6_TYTAL/7-225    AC A0A093GNR6.1
#=GS H0XH21_OTOGA/6-206        AC H0XH21.1
#=GS A0A091DAC2_FUKDA/113-180  AC A0A091DAC2.1
#=GS L5K895_PTEAL/6-209        AC L5K895.1
#=GS A0A2K5LKS6_CERAT/6-207    AC A0A2K5LKS6.1
#=GS G3TEL3_LOXAF/88-184       AC G3TEL3.1
#=GS W5KBK9_ASTMX/6-205        AC W5KBK9.1
#=GS A0A096MUB8_PAPAN/6-207    AC A0A096MUB8.1
#=GS F1SPI7_PIG/6-206          AC F1SPI7.1
#=GS A0A091EPA8_CORBR/7-223    AC A0A091EPA8.1
#=GS A0A1L8GPJ3_XENLA/6-214    AC A0A1L8GPJ3.1
#=GS A0A2I2YGS0_GORGO/9-199    AC A0A2I2YGS0.1
#=GS A0A1L8GHM5_XENLA/6-212    AC A0A1L8GHM5.1
#=GS A0A2G9RV07_LITCT/6-117    AC A0A2G9RV07.1
#=GS A0A0D9R9X9_CHLSB/2-203    AC A0A0D9R9X9.1
#=GS A0A091GBU8_9AVES/7-227    AC A0A091GBU8.1
#=GS A0A091DAC2_FUKDA/6-120    AC A0A091DAC2.1
#=GS H3C5L3_TETNG/6-81         AC H3C5L3.1
#=GS A0A091W0N2_NIPNI/7-227    AC A0A091W0N2.1
#=GS H3C5L3_TETNG/78-197       AC H3C5L3.1
#=GS A0A091KUK0_9GRUI/7-227    AC A0A091KUK0.1
#=GS R4GCM4_ANOCA/7-107        AC R4GCM4.1
#=GS G3WTB1_SARHA/6-157        AC G3WTB1.1
#=GS TRH_DANRE/3-70            AC Q5EDF9.1
#=GS G1ND92_MELGA/7-225        AC G1ND92.1
#=GS A0A2I0LUB3_COLLI/6-225    AC A0A2I0LUB3.1
#=GS A0A091Q0D0_LEPDC/7-227    AC A0A091Q0D0.1
#=GS G5C711_HETGA/6-115        AC G5C711.1
#=GS A0A094L2W6_ANTCR/7-227    AC A0A094L2W6.1
#=GS G1P8T9_MYOLU/6-207        AC G1P8T9.1
#=GS TRH_RAT/6-223             AC P01150.1
#=GS G1Q2W0_MYOLU/6-202        AC G1Q2W0.1
#=GS G7PIM4_MACFA/6-207        AC G7PIM4.1
#=GS A6QM11_BOVIN/6-207        AC A6QM11.1
#=GS A0A093NQW3_PYGAD/7-227    AC A0A093NQW3.1
#=GS A0A1S3ENE1_DIPOR/6-122    AC A0A1S3ENE1.1
#=GS A0A1B8XSL2_XENTR/6-214    AC A0A1B8XSL2.1
#=GS A0A1D5R2T3_MACMU/1-164    AC A0A1D5R2T3.1
#=GS H2TW65_TAKRU/6-234        AC H2TW65.1
#=GS G3GS26_CRIGR/6-214        AC G3GS26.1
#=GS A0A091WIM9_OPIHO/7-227    AC A0A091WIM9.1
#=GS H0ZJX5_TAEGU/7-224        AC H0ZJX5.1
#=GS R4GCM4_ANOCA/102-208      AC R4GCM4.1
#=GS A0A218UDP5_9PASE/7-224    AC A0A218UDP5.1
#=GS T0M605_CAMFR/6-209        AC T0M605.1
#=GS M7C513_CHEMY/5-225        AC M7C513.1
#=GS W5MZE0_LEPOC/103-245      AC W5MZE0.1
#=GS F6QAC6_ORNAN/1-82         AC F6QAC6.1
#=GS A0A1S2ZCD1_ERIEU/6-148    AC A0A1S2ZCD1.1
#=GS A0A093IMU8_EURHL/7-227    AC A0A093IMU8.1
#=GS A0A094LDL2_9AVES/8-228    AC A0A094LDL2.1
#=GS A0A093Q948_9PASS/7-227    AC A0A093Q948.1
#=GS Q1T735_ORYLA/6-232        AC Q1T735.1
#=GS A0A091IU67_EGRGA/7-227    AC A0A091IU67.1
#=GS A0A1S3MD66_SALSA/6-221    AC A0A1S3MD66.1
#=GS K7E2N6_MONDO/150-189      AC K7E2N6.1
#=GS A0A1U7V194_TARSY/33-178   AC A0A1U7V194.1
#=GS A0A091U920_PHORB/7-227    AC A0A091U920.1
#=GS G1SQS8_RABIT/7-210        AC G1SQS8.2
#=GS H2QNC9_PANTR/6-205        AC H2QNC9.1
#=GS A0A0A0ACE4_CHAVO/7-227    AC A0A0A0ACE4.1
#=GS B5XBV3_SALSA/6-224        AC B5XBV3.1
#=GS A0A1S2ZCD1_ERIEU/131-188  AC A0A1S2ZCD1.1
#=GS H2TW66_TAKRU/79-187       AC H2TW66.1
#=GS TRH_HUMAN/6-206           AC P20396.1
#=GS TRH_MOUSE/6-125           AC Q62361.2
#=GS M4AS06_XIPMA/6-234        AC M4AS06.1
#=GS L9JDC1_TUPCH/6-134        AC L9JDC1.1
#=GS G3NEZ6_GASAC/6-231        AC G3NEZ6.1
#=GS A0A1S3ENE1_DIPOR/99-190   AC A0A1S3ENE1.1
#=GS F7HLL6_CALJA/6-91         AC F7HLL6.1
#=GS A0A2D0QYL3_ICTPU/3-212    AC A0A2D0QYL3.1
#=GS A0A2K5HPM3_COLAP/6-207    AC A0A2K5HPM3.1
#=GS A0A2G9RV07_LITCT/99-208   AC A0A2G9RV07.1
#=GS TRH_DANRE/68-175          AC Q5EDF9.1
#=GS H2TW67_TAKRU/6-220        AC H2TW67.1
#=GS G1QZG4_NOMLE/6-207        AC G1QZG4.1
#=GS F1QKW8_DANRE/68-177       AC F1QKW8.1
#=GS I3KKT6_ORENI/6-235        AC I3KKT6.1
#=GS H3AN56_LATCH/7-227        AC H3AN56.1
#=GS A0A1U7RQM3_ALLSI/6-227    AC A0A1U7RQM3.1
#=GS A0A226PNL5_COLVI/13-244   AC A0A226PNL5.1
#=GS R0K990_ANAPL/7-227        AC R0K990.1
#=GS G5C711_HETGA/112-178      AC G5C711.1
#=GS TRH_CHICK/7-227           AC Q6ZXC3.2
#=GS A0A2I2YDN3_GORGO/6-207    AC A0A2I2YDN3.1
#=GS M3WV29_FELCA/45-241       AC M3WV29.2
#=GS A0A087Y6U4_POEFO/6-234    AC A0A087Y6U4.2
#=GS A0A091IDK5_CALAN/7-227    AC A0A091IDK5.1
A0A1U8BQT8_MESAU/127-172             .............................gffles------------.------------------......-----..------.----------------.------....-............-----------------.------.----..-.---....-........-WYLDQVKRQH.PGRRSFP...........................WM.E-S.DVT..KRQHP.GRRF....--.--.-----.--------------------.....-------.----------....................--..--.--...----------------------..----------.------spvstqk...........
H2TW66_TAKRU/6-81                    ...................................LLILASVVVCNL.IVCGGQGIPDEDELDRM-......AIDDI.iLQRAEG.LLLQSILRKMQSEDGR.S-GESS....Q............IDWVTKRQHPGKR----.------.----..-.---....-........-----------.-------...........................--.---.---..-----.----....--.--.-----.--------------------.....-------.----------....................--..--.--...----------------------..----------.------..................
H2P9C6_PONAB/6-206                   ...................................LLLALALTLNLT.GVPGGRAQPEAAQQEAVTaa.erpGLDDF..LRQVERlLFLRENIQRLQGDQGE.HSASQI...lQ............SDWLSKRQHPGKR--EE.EEE---.-GVE.eE.EEE....E........GGAVGPHKRQH.PGRREDEa.........................sWS.VDV.TQH..KRQHP.GRRS....--.--.----P.-WLGY--AVPKRQHPGRRLA.....-----DP.KAQRSWEEEE...................eEE..ER.EE...DLMPEKRQHPGKRAL-------..GGPCGPQGA-.-CGQA-g.................
D6RFM1_HUMAN/6-202                   ...................................LLLALALTLNLT.GVPGGRAQPEAAQQEAVTaa.ehpGLDDF..LRQVERlLFLRENIQRLQGDQAS.Q---IF....Q............SDWLSKRQHPGKREEEE.EEG---.-VEE..E.EEE....E........GGAVGPHKRQH.PGRREDEa.........................sWS.VDV.TQH..KRQHP.GRRS....--.--.----P.-WLAY--AVPKRQHPGRRLA.....-----DP.KAQRSWEEEE...................eEE..ER.EE...DLMPEKRQHPGKRAL-------..GGPCGPQGA-.------ygqa..............
F7HLL6_CALJA/89-178                  .................................kg------------.------------------......-----..------.----------------.------....-............-----------------.------.----..-.---....-........--AVGPHKRQH.PGRREDEv.........................sWS.VDA.TQH..KRQHP.GRRS....--.--.----P.-WLGY--AVTRRQHPGRRLA.....-----DP.KAQRS-----....................--..--.--...-LMPEKRQHPGKRAV-------..GSSCEPQGA-.-CG---qav...............
G3TEL3_LOXAF/5-91                    ..................................w--LLLALALTLT.CVPGCRAQPEVAQKEAVTaa.erpGLDDL..LRQAERlLLLREDLQRLRADRGE.RDTEPQt..lQ............LDWLSKRQHPGKT----.------.----..-.---....-........-----------.-------...........................--.---.---..-----.----....--.--.-----.--------------------.....-------.----------....................--..--.--...----------------------..----------.------vgp...............
A0A151MK38_ALLMI/41-262              ...................................LLLLLSLTLSGI.CLNLGQPTLDGGENGERS......HLDDI..LQRAES.ILLKSILKKVEEEEEL.NKEPDA...sE............PDSLSKQQHPGKRFFNE.LEKRQH.PGKR..E.DGE....E........ALYGDIQKRQH.PGKREEDd.........................dLD.RYL.ELQ..KRQHP.GKRS....LW.DQ.YVDAPgIQLTYLNELSKRQHPGKRYL.....VYAKRQH.PGKRGWED--....................EL..DL.GE...-QDLEKRQHPGKRFSDSESPDY..AAPCDLQDDF.NCSKGS..................
F1QKW8_DANRE/3-96                    ..............avcvfvlacvavsgapgvrgq------------.--------------DGP-......AEEEL..FQRAED.LLLRSILTQMEEQNSE.N----D....Q............PEWMEKRQHPGKR----.----QH.PGKR..E.EDL....E.......pEVEMERWRRQH.PGKR---...........................--.---.---..-----.----....--.--.-----.--------------------.....-------.----------....................--..--.--...----------------------..----------.------..................
A0A0Q3URX9_AMAAE/84-304              ..................................p-LLLLCLTLCSV.CLKERSPFPEGSENTGRS......LLDDI..LQRSDS.LILHSVFKKAEKEGEI.NKESNA...pL............PEWLSKRHHLGKKYLSE.LEKRQH.PGKR..D.VEE....D........TSYGDIQKRQH.PGKREIEd.........................dLD.SSL.ELK..KRQHP.GRRS....LL.EQ.DADNPsSQLTYLNELSKRQHLGRRYL.....-IYKYQH.PSKRGWND--....................EV..DL.ND...-RYREKHQHLGKKHWNFDSPDD..AGPCNFQESF.TCNKGS..................
K7FNZ1_PELSI/6-205                   ...................................LLLLLSLTLSSA.CVNLGQPIPEANENGERS......HLDDI..LQRAES.IILRSILKKAEEEEET.NKEPSA...sQ............PGWFSKRQHPGKRFLTD.LEKRQH.PGKR..E.EDD....D........-----------.-------...........................--.SDL.ELQ..KRQHP.GRRS....LW.DQ.YMDIPsTQLAYLHELSKRQHPGKRYL.....IYTKRQH.PGKRSWDD--....................EL..DL.RD...-QDMEKRQHPGKRYVDSESTDY..DAPCDFQESF.NCSKGS..................
K7E2N6_MONDO/6-157                   ................................llp--LLLSLTLSSV.SVNLGHSAAAEVDSEEQS......HLEEI..LQRAEH.LLLQSNLQKLEEDGEN.DSELQA...pQ............LNWLVKRQHPGKRFSEA.FEKRQH.PGKR..E.EED....EveegmedgGATMEAHKRQH.PGKREEE..........................aWE.ADG.EKP..KRQHP.GRRA....SW.VK.DSE--.--------------------.....-------.----------....................--..--.--...----------------------..----------.------edv...............
A0A093FXE0_GAVST/7-227               ..................................p-LLLLCLTLCGV.CLNGRQPLPEGSENMGRS......PLDDI..LQRSES.RILQSVLKKAEKEEDM.NKESNT...pL............PEWLSKRRHPGKRYLSD.LKKRQH.PGKR..D.VEE....D........TSYGDIQKRQH.PGKREIEd.........................dLD.GYL.ELK..KRQHP.GRRS....LS.DQ.YVDIPsAQLTYLNELSKRQHPGRRYL.....-MYTRQY.PSKRGWND--....................EV..DL.ND...-QYGEKRQHPGKRHWNSHSPDD..AGPCNFQESF.TCNKGS..................
A0A093ITK7_DRYPU/7-223               ..................................p-LLLLCLTLSGV.CLNGGQPLPEESENMVKP......PLGDI..LQRSES.R-LKSALKNAEEMNKE.P---NA...lL............PEWLSKRQHSGKKYLSD.LVKRQH.PGKR..D.AEE....D........TSYGDAQKRQY.PGKGETQd.........................dLD.SYL.ELK..KRQHP.GRRW....LS.DQ.DADTPaAQPTYFNQLPKRQHPGKRYL.....-MSKWQH.PSRRGWND--....................EV..EV.NK...-QYGEERQHAGKSPWNSDSPED..AGPCSFQEPF.TCSKGS..................
M3Z0M6_MUSPF/10-211                  ...................................LLLAVALTLTVA.GFPGGRAQPEVAQQEAAMaa.ehaGVDDL..LRQAERlLLLREDVQRLRGNQDD.RESESQi..iQ............PDWLSKRQHPGKR-EGD.AEE---.-GVE..E.EEE....E........GGAVGPHKRQH.PGRREDV..........................aAW.SDV.TQQ..KRQHP.GRHP....--.--.-----.SWLGY--TFTKRQHPGRRLV.....-----DS.KAQGSWEAEEe..................eEE..EE.EG...EPIPEKRQHPGKRAL-------..GGPCGPGGD-.-CGQAS..................
I3NCI2_ICTTR/6-204                   ...................................LLLTLALTLTLT.GSPGGRAQPQAAQQEAEMaa.ehpALDDL..LRQAEGfLLLQDDIQRLRGDLGQ.P-SESL....Q............PDSLSKRQHPGKR-EEE.AEE---.-GVE..E.EEE....E........GGAVGPHKRQH.PGRREDEa.........................aWSlDRT.QQR..KRQHP.GRRS....--.--.----P.-WLGP--ADTKRQHPGRRLV.....-----DA.QVQGSWREEQ....................EE..DAgEG...TPRVERRQHPGKRAL-------..GGPCAPQGA-.-C----aps...............
L9JDC1_TUPCH/126-198                 ............................appdrrw------------.------------------......-----..------.----------------.------....-............-----------------.------.----..-.---....-........-----------.-------...........................--.---.---..-----.----....--.--.-----.----LESAVAKRQHPGRRLV.....-----DP.KTHRSWEEEE....................ET..EE.EEgdgGLLPEKRQHPGKRAP-------..GVPCGPQGA-.-CGQA-g.................
A0A226MKF2_CALSU/22-239              ..................................p-VLLLCLTLSGV.CLNGRQPPPEASENMRS-......SLDDI..SQRSGS.HMLQSVLKKVEKKEEM.NKELNA...pL............PQWLYKRQHPGKRYVSD.LEKRQH.PGKR..D.AEE....E........TSYADIQKIQH.LGKTEDY...........................LA.NYP.ELK..KRQHP.GRRS....LW.DQ.STGIPsSQLTYLNELSKTQHPGRRYL.....-MYKHQH.PSKRGWND--....................EL..DL.SG...-QNWEKHQHSRKRHRDSDSLDY..AGPCDLQQSA.ICNKGS..................
A0A091U5R6_PHALP/8-227               ..................................r--LLLCLTLCGV.CLNGGQPLPEGRETMRRS......PLDDI..LQRSES.LILQSVLKKAEKGEEM.NKESNA...pL............PEWLCKRQHPGKKYLSD.LEKRQH.PGKR..D.VEK....D........TSYGDIQKRQH.PGKREIEd.........................dLD.SSL.ELR..KQQHP.GRRS....LL.DQ.FADIPsTQLTYLNELSKRQHPGRRYL.....-MYKHQH.LRRRGWND--....................EV..DL.ND...-QYGEKRQQPGKTHWNSDSPDD..VGPCNFQESF.ACNKGS..................
A0A091QB96_MERNU/7-227               ..................................p-LLLLCLTWPGV.CLSGGQSLPEGSENTGRS......LLDDI..LPRSES.LILQSLLKKAEKEEEM.NKESSA...pL............PEWLSERQHPGKKYLSV.LEKRQH.PGKR..D.VME....G........TSYGDIQKRQH.PGKRETEn.........................sLD.YYL.ELK..KRQHP.GRRS....LP.NQ.YPDIPsPQLTYLNESPKRQHPSRRYL.....-IYKYQH.PSKRGWSD--....................EV..DL.SD...-QFGEKRQHPGKRHWSSDSPAD..AGPCSLQEPF.PCNKGS..................
A0A093ILQ3_FULGA/7-227               ..................................p-LLLLCLTLCGV.CLNGGQPLPEGSENMGRS......PLDDI..LQRSES.LILQSVLKKAEKEEEM.NKESNA...pL............PEWLSKRQHPGKKYLSD.LEKRQH.PGRR..D.VEE....D........ASYEDIQKRQH.PGKREIEd.........................dLY.GYL.ELK..KQQHP.GRSS....LS.DQ.YADIPrAQLTYVNDLSKRQHPGRRYL.....-MYKRQH.PSKRGWND--....................EV..DL.ND...-QYGEKRQHPGKRHWNPDSPDD..AGPCNFQESF.TCNKGS..................
A0A099YTJ5_TINGU/7-226               ..................................p-LLLLCLSLCTH.CLRRGQPLPGGGTNVEKR......PLDDN..MREAES.LILQSVLKKSEEEKIN.KESNTP....L............PEWLSKRQHPGKRYISD.LEKRQH.PGKR..E.DAE....E........SSYGDIQKRQH.PGKREEEg.........................sLA.RYL.ELK..KRQHP.GRRS....LW.DQ.HADTPsAQLTYLNELSKRQHPGKRYL.....-PYKLQH.PGSRGWND--....................EQ..DL.RD...-QHVEKRQHPGKRYLDTKNPEY..AAPCDFQESS.SCNEGS..................
G3WTB0_SARHA/6-156                   ................................llp--LLLSLALSSF.SINLGQPAAAEADSEEKG......RLEEI..LQRAEN.LFLQSNLQKLEEEGEN.NSDLQA...pP............LDWLVKRQHPGKREEED.EGE---.--EE..E.AGD....E........GTTIEIHRRQH.PGKREEE..........................tWE.EDG.KEQ..KRQHP.GRRA....SW.LK.DSE--.------GDISKRQHPGRRSL.....-------.----------....................--..--.--...----------------------..----------.------g.................
W5MZE0_LEPOC/6-119                   ...................................LILLVSLTVCNL.TVNLGQNIPDESDKEERV......PLDDI..LQRAQN.IIFRSLLKKIEDEDKL.NDQVSS....Q............QEWLSKRQHPGKRYQED.IEKRQH.PGRR..E.EDE....D........LRYPDFEKRQH.PGRREE-...........................--.---.---..-----.----....--.--.-----.--------------------.....-------.----------....................--..--.--...----------------------..----------.------d.................
A0A2I2UZ94_FELCA/6-202               ...................................LLLALALTLTVA.GIPGGRAQLEVAQHEAGEh....aGLDDL..LRQAERlLLLQEDLLRLRGNQDD.GESESQi..iQ............PDWLSKRQHPGKREEEE.AED---.-GVE..E.EEE....-........GGAMGPHKRQH.PGRREDV..........................aAW.SEV.TQQ..KRQHP.GRRS....--.--.-----.SWLGY--TFTKRQHPGRRLV.....-----DP.KAQRSWEEEE....................EE..VE.EG...ELMPEKRQHPGKRAL-------..GGPCEPQGA-.-CGQAS..................
TRH_MOUSE/140-224                    ...............................flds------------.------------------......-----..------.----------------.------....-............-----------------.------.----..-.---....-........-----------.-------...........................WF.SDA.PQV..KRQHP.GRRS....--.--.---FP.-WM--ESDVTKRQHPGRRFI.....-----DP.ELQRSWEE--....................TE..GE.EG...GLMPEKRQHPGKRAV-------..GHPCGPQGI-.-CGQT-g.................
S7PNX2_MYOBR/6-207                   ...................................LLLALALTLTLT.GVPGGRAQPEVDQQEAAMaa.ehpALRDL..LRQAGHlLLLREDLQRLQGDQGN.RESESQi..fQ............SNGLSKRQHPGKR-EEE.AEE---.-GVE..D.EEE....E........GGAVGPHKRQH.PGPWENAa.........................aWS.VDV.TPQ..KRQHP.GRRS....--.--.-----.FWLGY--TFTKRQHPGRRLV.....-----DP.KAQRSWEEEE...................eEE..EE.DG...ELMPEKRQHPGKRAL-------..GGPCGLQGD-.-CGQAS..................
A0A2G8L3S2_STIJA/164-319             ..........................dalddkrqy------------.------------------......-----..------.----------------.------....-............--FAGKRQLPGGLEIDD.--KRQYfAGKR..D.FED....E........---VDEAKRQYfAGKRQLPg.........................gDL.DGL.EEE..KRQHFlGKRQ....LL.DG.WIDVE.DKRQY--FAGKRQLPGGLAT.....-DDKREYfTGDRED---G....................FE..DI.KR...QYFAGKRQLPGGLELDNPAEKR..----------.------qlpgspwkfwegk.....
G3R1J0_GORGO/4-197                   .............................svglic----LCLALTHT.EPPG-----ARVQXXXXP......GLDDF..LRQVERlLFLRENIQRLQGDQGE.HSASQI...fQ............SDWLSKRQHPGKREEKE.-EE---.-GVE.eE.EEE....E........GGAVGPHKRQH.PGRREDEa.........................sWS.VDV.TQY..KRQHP.GRRS....--.--.----P.-WLAY--AVPKRQHPGRRLA.....-----DP.KSQRSWEEEE...................eEE..ER.EE...DLMPEKRQHPGKRAL-------..GGPCGPQGA-.-CGQA-g.................
A0A087QJF5_APTFO/7-227               ..................................p-LLLLCLTLCGV.CLNDGQPLPEGSENMGRS......TLDDI..LQRSES.IILQSVLKKAEKEDEM.NKESNA...pL............PEWLSKRQHPGKKYLSD.LEKRQH.PGRR..H.VEE....D........TSYGDIQKRQH.PGKREIEd.........................dLD.GYV.QLK..KQQHP.GRRS....LS.DQ.YADIPnAQLAYLNELSKRQHPGRRYL.....-MYKRQH.PSKRGWND--....................EV..DL.ND...-RYGEKRQHPGKRHWNSDSPDD..AGPCNFQESF.TCNKGS..................
A0A1A6HWM7_NEOLE/6-216               ...................................LLLALALIFSLT.GIRESCALLEEAAQEEGAv...tlGLGNV..QMRPEH.RLLRKDLQRVRGDLGA.A-----....L............DSWITKRQHPGKREEEEeIEA---.-EER..G.DWG....E........GGAWSPHKRQH.PGRRANQ...........................-D.KYS.WLD..SDWLP.PSRL....-P.DF.LLDSW.-SLGI--PQVKRQHPGRRSFpwlesDVTKRQH.PGRRFMDPKFqg...............sweEK..EG.EG...VPMPEKRQHPGKRAV-------..GHPCGPQGT-.-C----gll...............
F7HLL2_CALJA/6-207                   ...................................LLLALALTLNLI.GVPGGRAQPEAAQQEAVTaa.erpGLNDL..LRQAERlLFLRENILRLQGDQGE.HSASQI...lQ............PDWLSKRQHPGKR-EEE.EEV---.-GVE..EeEEE....E........EGAVGPHKRQH.PGRREDEv.........................sWS.VDA.TQH..KRQHP.GRRS....--.--.----P.-WLGY--AVTRRQHPGRRLA.....-----DP.KAQRSWEEEE...................eEE..ER.KE...ELMPEKRQHPGKRAV-------..GSSCEPQGA-.-CG---qav...............
A0A0P7X5Y1_9TELE/5-216               ..................................c-LILLALAVCDL.NVNQGQKILGEEEDGGA-......-----..LRRAES.LLLRSILKEMGDADTD.HDQAF-....L............QEWISKRQHPGKRYEDD.IEKRQH.PGKR..E.EEE....D........MDYSDLQKRQH.PGKREDG...........................--.--V.ELQ..RRQHP.GKRS....VL.EL.LTDSPsAQVPYVGDLSKRQHPGKRYL.....VYNKRQH.PGRRELEDEV....................DT..AI.-D...QVEVEKRQHPGKRYWENTDPNLgpDNPCDVQDPT.GCSKA-m.................
A0A2I4BUQ6_9TELE/6-233               ...................................LLIVASLALCYL.TVSHGQGISAEDEADRGT......TIDDI.iLQRAES.LLLRSILKKLQDGNGP.SEGLFS....Q............PEWVTKRQHPGKRFS--.-EKRQH.PGRR..E.EEEe..eD........EQFLEVQRRQH.PGKREDE...........................VR.AFVaGLQ..KRQHP.GKRA....AAgGQ.LSDSP.--LSLLSELSKRQHPGKRYL....vMHSKRQH.PGKRYLEDGDsd................wnAD..AD.ED...FAELEKRQHPGKRLWDNGSPELstGSPCDVLDPD.SCSKTS..................
W5PU12_SHEEP/45-246                  ...................................FLLAMALTLTLT.SVPGGRAQLDVVQQDVDLse..qqGLEDL..LRQAERlLLLREDLQRLREDQDD.SASESQi..fQ............PDWFSKRQHPGKREEEE.ADE---.-GVE..G.EEE....E........GGAVGLRKRQH.PGRRDDVa.........................aWA.VDA.GQQ..KRQHP.GRRA....--.--.-----.SWLGY--AVTKRQHPGRRLV.....-----DP.RPQRSWEEAG...................eDE..DE.GG...ELMSEKRQHPGKRAL-------..GSPCGPRGP-.-CGQAS..................
A0A093HSA7_STRCA/7-227               ..................................p-LLLLCLTLRGA.CLKEGQPLPEGSDHMERS......PLDDN..LQRAES.LILQSVLQKSEEEEKI.NKESNA...pL............PEWLSKRQHPGKRYVSD.LEQTEH.PGKG..E.DEE....E........SSYGDIQKRQH.PGKREEDd.........................nLD.SYQ.ELK..KRQHP.GRRS....LW.DQ.HAAIPsAQLVYLNELSKRQHPGKRYS.....-MYKLQH.LGSRGWND--....................EL..DL.RD...-QHVEKHQHPGKRYWDSKSPDY..AAPCDLQESL.SCNKGS..................
A0A1U8BQT8_MESAU/6-125               lllplaliftltgipefcalpvadqeegvvqmlpe------------.------------------......-----..-----R.RFLQKDLQRVRGDLGA.-----A....L............DSWITKRQHPGKREEEEeIEA-EE.G--G..D.LGE....-........EGAWSPHKRQH.PGRRANQ..........................dKY.---.---..-----.----....--.--.-----.--------------------.....-------.----------....................--..--.--...----------------------..----------.------swveaedsnwvpttrl..
W5MZE8_LEPOC/6-228                   ...................................LILLVSLTVCNL.TVNLGQNIPDESDKEERV......PLDDI..LQRAQN.IIFRSLLKKIEDEDKL.NDQVSS....Q............QEWLSKRQHPGKRYQED.IEKRQH.PGRR..E.EDE...dD........DDYFEEQKRQH.PGKREDE...........................TD.DYV.ELQ..RRQHP.GKRS....LM.DQ.YSDATdSQMGYQSDMSKRQHPGKRYL.....SYNKRQH.PGRRELEN--....................EL..DA.GD...LQDLEKRQHPGKRYWDIKSPDYinNLPCDIKDPV.KCNKAS..................
L5M7T1_MYODS/6-207                   ...................................LLLALALTLTLT.GVPGGRAQPEVDQQEAAMaa.ehpALRDL..LRQAGHlLLLPEDLQRLQGDQGN.HESESQi..fQ............SNGLSKRQHPGKR-EEE.AEE---.-GVE..E.EEE....E........GGVVGPHKRQH.PGPWENAa.........................aWS.VDV.TPQ..KRQHP.GRRS....--.--.-----.FWLGY--TFTKRQHPGRRLV.....-----DP.KAQRSWEEEE...................eEE..EE.EG...ELMPEKRQHPGKRAL-------..GGPCGLQGD-.-CGQAS..................
Q4RJV2_TETNG/1-226                   ..............................mirqi------TMVCNL.IVCGGQGMPDEDELERM-......TIDDI.iLQRAEG.LLLQSILRKMQSENGR.S-GESS....Q............IEW-TKRQHPGKRYVED.VEKRQH.PGRR..E.MED....D........---LDVQKRQH.PGKRDDE...........................MH.SFV.EIQ..KRQHP.GKRT....AM.GH.DTENP.--VLLLSELSKRQHPGRRYL....vLHAKRQH.PGKRHFEEEDidgdw..........dsdanAD..DV.ED...IAELEKRQHPGKRFWDNSNPDLgaDNPCDVLDPT.SCSKTS..................
A0A093TKE2_PHACA/7-227               ..................................p-LLLLCLTLCGV.CRNGGQPLPVGSETMGRS......PLDDI..LQRSES.LILQSVLKKAEKDEEM.NKESNA...pL............AEWLSKRQHPGKKYLSD.LEKRQH.PGKR..D.AEE....D........TPYGDIQKRQH.PGKREIKd.........................dLD.GYL.ELK..KQQYP.GRRS....LL.DQ.YADIPsAQLTYLNELSKRQHPGRRYP.....-MYKRQH.PSKGGWND--....................EV..DL.ND...-QYGEKRQHPGKRHWNSDSPDD..AGPCNFQEPF.TCNKG-g.................
A0A1V4JIY5_PATFA/7-225               ..................................p---LLLLTLAAV.CLHAGLLLPEGREKAGTS......PLDDI..LQRSES.LLLQSVLKRAEKEEET.KKEANA...pL............PEWLSKRQHPGKKYLSD.LEKRQH.PGKR..D.VGG....D........TFDGDIQKRQH.PGKREIEd.........................dLD.GYL.ELR..KRQHP.GRRS....LS.DQ.LDDIPsAQLTHLNELSKRQHPGRRYL.....-MYKRQH.PSKRGWND--....................EV..DL.DD...-QVGEKRQHPGKRLWNSGGPDD..AGPCDVQEPF.TCNKGS..................
D2HGM5_AILME/6-207                   .................................lq--LAMALTLTVA.GIPGGRAQPEVAQQEAAMap.eraGLDDL..LRQAQRlLFLREDLQRLRGNQGD.LESEAQi..lQ............PDWLSKRQHPGKR-EGE.AEE---.-GVE..E.EEE....E........GGAVGPHKRQH.PGRQEDV..........................aAW.SDV.TLQ..KRQHP.GRRA....--.--.----P.-LLGY--AFTKRQHPGRRLV.....-----DS.KAQRSWEAEEe..................dGE..EE.GG...EPMPEKRQHPGKRAL-------..GSPCGPGAA-.-CGQAS..................
C3ZWL4_BRAFL/145-309                 ............................ltdsfll------------.------------------......-----..------.----------------.------....-............-QSTDKRQSPGKR--QS.PGKRQS.PGKR..Q.SPG....K........--RQSPGKRQS.PGKRGDD...........................-E.ITL.PMG..LRFEP.LFSS....AL.SEsSTDKR.QSAGKRQSPGKRQSPGKRQS.....-PGKRQS.PGKRTFPFPGtpqmethdatdaranlltllDL..VE.QK...RQSPGKRQHPGKRA--------..----------.------dwlrpspeepw.......
E2RHA2_CANLF/6-205                   ...................................LLLAMALTLTVA.GIPGGSAQPEVAQQEAAMaa.ehaDLDDL..LRQAERlLLLREDLQRLRGNQGN.PESESQt..vQ............TNWLSKRQHPGKR-EGE.AEE---.-GVE..E.EEE....E........GLAVGPHKRQH.PGRREDA..........................aAW.SDG.TQQ..KRQHP.GRRS....--.--.-----.SWLEY--AVTKRQHPGRRLV.....-----DP.KAQMSWEAEE....................EE..GE.EG...ELMPEKRQHPGKRAL-------..GGPCGTGGA-.-CGQA-r.................
A0A091GN18_BUCRH/7-227               ..................................p-LLILCLTLSGV.CLSGGQPLPEGSENIGRS......PLGDV..LQRTES.LILQSLLKKAEKGEEM.NKELNA...pL............PEWLSKRKHPGEKYLSD.LEKRQH.PGKR..G.AEE....D........RSYEDIQKRQH.PGKREIGd.........................dLD.GYL.ELK..ERQHP.GRRS....LL.DQ.YADIPsAQLTYLSELSKRQHPGRRYL.....-MYKRQH.PSKRGWND--....................EA..DL.ND...-QYGEKRQHPGKRHWNSDSPDD..AGPCNVPESF.ACNKGS..................
A0A2I2U1H2_FELCA/34-230              ...................................LLLALALTLTVA.GIPGGRAQLEVAQHEAGEh....aGLDDL..LRQAERlLLLQEDLLRLRGNQDD.GESESQi..iQ............PDWLSKRQHPGKREEEE.AED---.-GVE..E.EEE....-........GGAMGPHKRQH.PGRREDV..........................aAW.SEV.TQQ..KRQHP.GRRS....--.--.-----.SWLGY--TFTKRQHPGRRLV.....-----DP.KAQRSWEEEE....................EE..VE.EG...ELMPEKRQHPGKRAL-------..GGPCEPQGA-.-CGQAS..................
F7B653_HORSE/6-206                   ..................................s-LLAMALTLTLT.GVPGGRSQPEAAQQEAAMga.ehpGLDDL..LRQAERlLLLREDLQRLREDQGE.RESESQi..fQ............PNWLSKRQHPGKR-EEE.AEE---.-RVE..E.EEA....E........EGAVGRHKRQH.PGRREDEa.........................aWS.ADA.TQQ..KRQHP.GRRS....--.--.-----.SWLGY--TFTKRQHPGRRLV.....-----DP.QAQRSWEDEE....................EE..RE.EG...ELMPEKRQHPGKRAL-------..GSPCGPRGA-.-CGQAS..................
U3KGX4_FICAL/7-224                   ..................................p-LLLLCLTLCGV.CFNGGHLLPEESKNMGKS......PLDDI..LQRSES.FILQSVLKKAEKEEEI.NKESNA...pL............LQWLSKRQHPGKKYLSN.LEKRQH.PGKR..D.VEE....E........TSYGDIQKRQH.PGKREMEd.........................dPD.VYL.ELI..RQQPP.RRKS....LL.DQ.FANSPrAQLTYANKLSTREHPGRRYP.....-MYKHQR.PSKRGWNY--....................EV..DL.YS...----EKLQHPGKRHWNSGSSGD..TGPCNFQESF.TCHKGS..................
F7AY27_XENTR/6-214                   ...................................WLLLLATTLSQM.VHTQEQPLLEEDSA----......PADNLdvLEKAKG.ILIRSILEGFQEGQQN.KRAFPD....E............MEMISKRQHPGKRFQEE.LEKRQH.PGKR..D.LGD....-........-LNLELSKRQH.PGRRFLE...........................--.---.EIE..KRQHP.GKREegewSR.GY.RSDDS.SYLDLLSDVSKRQHPGKRIPd...pLFTKRQH.PGKREAEEED....................DT..EF.EI...SKEVAKRQHPGKRF--------..-DPCEGPNAY.NCNSG-n.................
A0A093GNR6_TYTAL/7-225               ..................................p-LLLLCLTLCGV.YLNTGQPLPERSENMRRG......PLDDI..LQRSES.LILQSVFKKAEKEKEM.NKESNA...pL............QERLSKRQHPWKKYLSD.LEKRQH.PGKR..D.VEE....D........ASFGDIQKRQH.PGKREIEd.........................dLG.NYL.ELK..KQQHP.GRRS....LS.DQ.YADIPnAQLTYLKELSKRQHPGRRYL.....-MYK--H.PSKRGWND--....................EV..DL.ND...-QHGEKRQHPGKRHLNSDSTDD..AGLCNFQESF.PCNKGS..................
H0XH21_OTOGA/6-206                   ...................................LLLALALTLTLT.GVPSGRAQLEEAQQEAVTaa.ehpGLDNL..LRQAERlLFLRENFRRLQGDQNE.PSESQI...iQ............PNWLSKRQHPGKR-EEE.AEE--G.VEEE..E.EEE....E........GGAVGPHKRQH.PGRRADEa.........................sWS.ADG.SQH..KRQHP.GRRS....--.--.----P.-WPGY--AVTKRQHPGRRLV.....-----DP.KAQRNWEEEG....................LE..GE.-E...ELMPEKRQHPGKRGL-------..GGPCGPQGA-.-CDQAS..................
A0A091DAC2_FUKDA/113-180             ................................rsp------------.------------------......-----..------.----------------.------....-............-----------------.------.----..-.---....-........-----------.-------...........................--.---.---..-----.----....--.--.-----.-WLEY--VITKRQHPGRRLV.....-----DP.HSQRSWEEED...................tEE..DR.EG...APIPKKRQHPGKRAL-------..GRPCGPQGA-.-CGQAS..................
L5K895_PTEAL/6-209                   ...................................LLLAMALTLTLT.DVPRGSAQPEVAQQEAAMat.eypGLDDL..LRQAERlLLLREDLQRLRGDQGD.RESESQi..fQ............PDWLSKRQHPGKR-EEE.AEE---.-RVE..E.EEE....E........EGAVGPHKRQH.PGRREDAa.........................vWS.LEA.TQQ..KRQHP.GRRS....--.--.-----.SWLGY--TFTKRQHPGRRLV.....-----DP.KAQRSWEEEEd.................gkEQ..EE.EG...ELMPEKRQHPGKRAM-------..GGPCRLRGA-.-CGQAS..................
A0A2K5LKS6_CERAT/6-207               ..................................s-LLALALTLNLT.GVPGGRAQPEAAQQEAVTaa.erpGLDDL..LRQVERvLFLRENIQRLQGDQGE.HSASQI...lQ............SDWLSKRQHPGKREEEE.EEG---.-VEE..E.EEE....E........AGAVGPHKRQH.PGRREDEa.........................sWS.VDV.TQH..KRQHP.GRRS....--.--.----P.-WLGY--AVTKRQHPGRRLA.....-----DP.KAQRSWEEEE...................eEE..ER.EE...ELMPEKRQHPGKRAL-------..GGPCGPQGA-.-CGQA-g.................
G3TEL3_LOXAF/88-184                  ..................................t------------.------------------......-----..------.----------------.------....-............-----------------.------.----..-.---....-........---VGPQKRQH.PGRREDEv.........................sWS.VDV.IQQ..KRQHP.GRRS....--.--.----P.-WLGY--TITKRQHPGRRLV.....-----DS.KAQRSWEE--....................-E..EE.EG...AVMPEKRQHPGKRAL-------..EGPCGPWGA-.-CDQA-a.................
W5KBK9_ASTMX/6-205                   ...................................LILLSFLALCNL.SGTQCQNIPAAEEEPGER.....pSLEEI..LQRAQT.LLMRAIIKKMEEEGNA.EETFAP....Q............SEWLEKRQHPGKR----.----QH.PGRR..E.EEE....E........ED---------.-------...........................-G.DYP.ELQ..KRQHP.GKRW....ML.EQ.MMETPgAQNALLNELAKRQHPGKLLV.....LYSKRQH.PGRREAGA-E....................EP..DS.GD...LWEMDKRQHPGKRFWDASPSDAsaGTPCDLLASSpGCSKA-g.................
A0A096MUB8_PAPAN/6-207               ...................................LLLALALTLNLT.GVPGGRAQPEAAQQEAVTaa.erpGLDDL..LRQVERvLFLRENIQRLQGDQGE.DSASQI...lQ............SDWLSKRQHPGKREEEE.EEG---.-VEE..E.EEE....E........AGAVGPHKRQH.PGRREDEa.........................sWS.VDA.TQH..KRQHP.GRRS....--.--.----P.-WLGY--AVTKRQHPGRRLA.....-----DP.KAQRSWEEEE...................eEE..ER.EE...ELMPEKRQHPGKRAL-------..GGPCGPQGA-.-CGQA-g.................
F1SPI7_PIG/6-206                     ...................................FLLAMALTLTLT.SVPGGHAQLEVAQQEGAIaa.ehpGLDDL..LRQAEH.LLLREELQRLREDQGD.SESESQt..fQ............PNWLSKRQHPGKR-EEE.AEG---.-RVE..E.EEE....E........GGAVEPHKRQH.PGRREDAa.........................pWP.VEV.AQQ..KRQHP.GRRS....--.--.----P.-WLRY--TFTKRQHPGRRLV.....-----DP.KAQRSLEEEE...................eEV..EE.DG...ELMPEKRQHPGKRAL-------..RSPCGPWGS-.-CGQAS..................
A0A091EPA8_CORBR/7-223               ..................................s-LLLLCLTLCGV.CFNGGHLLPEESENMGRS......PLDDI..LQRSES.LILQSVLKKAEKEEEI.NKESNA...pL............LQWLSKRQHPGKKYLSN.LEKRQH.PGKR..D.VEK....D........TSYGDIQKRQH.PGKRDID..........................dLG.IYL.ELK..RQQPP.GRKS....LL.DQ.FANSPrAQLTYMNELTQREHRGRRYP.....-MYKHQH.PSERGWNY--....................EV..DL.YG...----EKHQHPGKRHWNSDSSDD..TGPCNLQGSF.TCHKGS..................
A0A1L8GPJ3_XENLA/6-214               ...................................WLLLLGTTVSHM.VHTQEQPLLEEDTA----......PLDDLdvLEKAKG.ILIRSILEGFQEGQQN.NRDLPD....A............MEIISKRQHPGKRFQEE.IEKRQH.PGKR..D.LED....-........-LNLELSKRQH.PGRRFVD...........................--.---.DVE..KRQHP.GKREegdwSR.RY.LTDDS.RYLDLLSDVSKRQHPGKRVPa...pLFTKRQH.PGKRETEEEG....................DT..EF.EN...SKEVGKRQHPGKRY--------..-DPCEGPNAY.NCNSG-n.................
A0A2I2YGS0_GORGO/9-199               .............tlsllgpagsagpsplattxxx------------.----------------XP......GLDDF..LRQVERlLFLRENIQRLQGDQGE.HSASQI...fQ............SDWLSKRQHPGKREEKE.-EE---.-GVE.eE.EEE....E........GGAVGPHKRQH.PGRREDEa.........................sWS.VDV.TQY..KRQHP.GRRS....--.--.----P.-WLAY--AVPKRQHPGRRLA.....-----DP.KSQRSWEEEE...................eEE..ER.EE...DLMPEKRQHPGKRAL-------..GGPCGPQGA-.-CGQA-g.................
A0A1L8GHM5_XENLA/6-212               ...................................WLLLLGTAISHK.VHSQEQPLLEEDTA----......PADNLdvLEKAKG.ILIRSILEGFQEGQQI.NRDLPD....A............MEMIYKRQHPGKRFQEE.IEKRQH.PGKR..D.LED....-........---LQLSKRQH.PGRRYLE...........................--.---.DME..KRQHP.GKREegdwSR.GY.LTDDS.GYLDLFSDVSKRQHPGKRVPd...pLFIKRQH.PGKRGIEEED....................DT..EF.EN...SKEVGKRQHPGKRY--------..-DPCEGPNAY.NCNSG-n.................
A0A2G9RV07_LITCT/6-117               ...................................WLLLLGAALSHV.TVAQEQPLPDDEDSFPDD.....gDVSST..LKKTHG.ALIRSILRRIEEEQTE.KDSDSP....A............LEWISKRQHPGKRFLEE.VEKRQH.PGKR..E.EGD....-........-LYLELPKRQH.PGRRS--...........................--.---.---..-----.----....--.--.-----.--------------------.....-------.----------....................--..--.--...----------------------..----------.------f.................
A0A0D9R9X9_CHLSB/2-203               ...................................LLLALALTLNLT.GVPGGRAQPEAAQQEAVTaa.erpGLDDL..LRQVERvLFLRENIQRLQGDQGE.HSASQI...lQ............SDWLSKRQHPGKREEEE.EEG---.-VEE..E.EEE....E........AGAVGPHKRQH.PGRREDEa.........................sWS.VDV.TQH..KRQHP.GRRS....--.--.----P.-WLGY--AVTKRQHPGRRLA.....-----GP.KAQRSWEEEE...................eEE..ER.EE...ELMPEKRQHPGKRAL-------..GGPCGPQGA-.-CGQA-g.................
A0A091GBU8_9AVES/7-227               ..................................p-LLLLCLTSCGV.CLNGRQPIPERSENMGRS......PLDDI..LQTSES.LILQSVLKNAKKEEEM.LKDSNS...pL............PEWLSKRQHPGKKYLND.LEKRQH.PGKR..D.VEE....D........VSYGDIQKRQH.PGKREIEa.........................dLD.SYL.ELK..KRQHP.GRRS....LS.DQ.YTDIPsAQLTYLDELSKRQHPGRRYL.....-MDKHQY.PSKRGWND--....................EV..DL.ND...-QYNEKQHHSGKRHWNSDSPDN..AGPCSFQESF.TCNKGS..................
A0A091DAC2_FUKDA/6-120               .................................wp--LTLALALILT.NVLGGHAQPEAVMVAEGP......GLDDL..LQQAERlLLLQEDLQGLPGVPVE.HESQVL....Q............PDWLSKRQHPGKR-EED.TKE--G.P-EE..E.EEE....E........GGAAGPQKRQH.PGRRS--...........................--.---.---..-----.----....--.--.-----.--------------------.....-------.----------....................--..--.--...----------------------..----------.------pwleyv............
H3C5L3_TETNG/6-81                    ...................................LLIVASVMVCNL.IVCGGQGMPDEDELERM-......TIDDI.iLQRAEG.LLLQSILRKMQSENGR.S-GESS....Q............IEW-TKRQHPGKR----.------.----..-.---....-........-----------.-------...........................--.---.---..-----.----....--.--.-----.--------------------.....-------.----------....................--..--.--...----------------------..----------.------q.................
A0A091W0N2_NIPNI/7-227               ..................................p-LLLLCLTLCGV.CLNGGQPLPEGSENKGRS......PLDDI..LQRSKS.LILQSVLKKAEKEEEM.NKESNA...pL............PEWLSKRQHPGKKYLSD.LEKRQH.PGKR..D.IEE....D........TSYGDIQKRQH.PGKREIEd.........................dLD.GYL.ELK..KQQHP.GRRS....LS.DQ.YADTAsAQLNYLNKLSKRQHPGRRYL.....-MYRRQY.PSKRGWND--....................EL..DL.ND...-QYGEKRQHPGKRHWNSDSPDD..AGPCNFQESF.TCNKGS..................
H3C5L3_TETNG/78-197                  ..................................g------------.------------------......-----..------.----------------.------....-............-----------------.------.----..-.---....-........-------KRQH.PGKRDDE...........................MH.SFV.EIQ..KRQHP.GKRT....AM.GH.DTENP.--VLLLSELSKRQHPGRRYL....vLHAKRQH.PGKRHFEEEDidgdw..........dsdanAD..DV.ED...IAELEKRQHPGKRFWDNSNPDL..----------.------dfldnisk..........
A0A091KUK0_9GRUI/7-227               ..................................p-LLLLCLTLCGV.CLNGGQPLLEASENMGRS......PLDNI..LQRSES.LILQSVLKKAEKEEEM.NKESNA...pL............PEWLSKRQHSGKKYLSD.LEKRQH.PGKR..D.VEE....D........TSYGGIQKRQH.PGKREIEd.........................nLD.GYL.ELK..NQQHP.GRRS....WL.DQ.YADIPtARLTYLNELSKRQHPGRRYL.....-MYKHQN.SRKRGWND--....................EV..EL.NG...-QYGEKRQQPRKRHWNSDSPDD..ASPCSFQESF.ICNKGS..................
R4GCM4_ANOCA/7-107                   ...................................LLLLFSLAFTSV.CGNLGQSFPEEDENEEKA......HLDDI..FQRAES.IILRSVFRKMEEDEEDpNKDLDT...pQ............LDQITKRQHPGKRDLYS.LEKRQH.PGKR..D.QGD....-........-----------.-------...........................--.---.---..-----.----....--.--.-----.--------------------.....-------.----------....................--..--.--...----------------------..----------.------gfnl..............
G3WTB1_SARHA/6-157                   ................................llp--LLLSLALSSF.SINLGQPAAAEADSEEKG......RLEEI..LQRAEN.LFLQSNLQKLEEEVGD.SFQLNHf.fwV............IQIFEKRQHPGKREEED.EGE---.--EE..E.AGD....E........GTTIEIHRRQH.PGKREEE..........................tWE.EDG.KEQ..KRQHP.GRRA....SW.LK.DSE--.------GDISKRQHPGRRSL.....-------.----------....................--..--.--...----------------------..----------.------..................
TRH_DANRE/3-70                       ...............avcvfvlacvavsgapgvrg------------.-------------QDGP-......AEEEL..FQRAED.LLLRSILTQMEEQNSE.N----D....Q............PEWMEKRQHPGKR----.------.----..-.---....-........-----------.-------...........................--.---.---..-----.----....--.--.-----.--------------------.....-------.----------....................--..--.--...----------------------..----------.------q.................
G1ND92_MELGA/7-225                   ..................................p-VLLLCLTLSGV.CLNGRQSPPEVREKMGRS......SLDDI..LQRSGS.HMLQSAVKKLEKKEEM.NKELNV...pL............PQWLSKRQHPGKRYISD.LEKRQH.PGRR..D.VEE....A........ASFGDIQKRQN.LGKTEGY...........................LA.NYL.ELK..KRQHP.GRRS....LW.DQ.STDISnSQLTYLNELSKRQHPGRRYL.....-MYKHQH.PSKRSWND--....................EL..DL.GD...-QNWEKHQNFGKRNRDSDSPDY..AGPCDLQQSA.ICNKGS..................
A0A2I0LUB3_COLLI/6-225               .................................lp---LLLLTLAGV.GLHAGLLLPEGREKAGTS......PLDDI..LQRSES.LLLQSVLKRAEKEGET.KKEANA...pL............PEWLSKRQHPGKKYLSD.LEKRQH.PGKR..D.VEG....D........TFDGDIQKRQH.PGKREIEd.........................dLE.GYL.ELK..KRQHP.GRRS....LS.DQ.LDDIPsVQLTYLNELSKRQHPGRRYL.....-TYKRQH.PSKRGWND--....................EV..EL.DD...-QHGEKRQHPGKRLWNSGGPDD..AGPCNFQEPF.TCNKGS..................
A0A091Q0D0_LEPDC/7-227               ..................................p-LLLLCLTLSGV.CLNGGQSLPEGSENMGRS......PLDDI..LQRSKS.LILRSVLKKAEKEEEM.NKESNA...hL............PEWLFKRQHPGKKYLSD.LEKRQH.PGKR..D.VEE....D........TSYGDTQKRQH.PGKRETEd.........................dLD.SYL.ELK..KRQHP.GRRS....LS.DQ.YADTPrAQLTYLNELSKRQHPGRRYL.....-TYKHQH.PSKRGWND--....................EV..DL.ID...-QYGEKHQHLGKRHWDSDSPGD..AGPCNFQESF.TCNKGS..................
G5C711_HETGA/6-115                   .................................wp--LALALALILT.GVPGGHAQHEPVMVAEGP......GLDDL..LQQAERlLLLQGDLRGLPGAALE.HESQVL....Q............PAWLSKRQHPGKR-EED.TEE---.-GPE..E.EEE....E........GGAMGPQKRQH.PGRRS--...........................--.---.---..-----.----....--.--.-----.--------------------.....-------.----------....................--..--.--...----------------------..----------.------pw................
A0A094L2W6_ANTCR/7-227               ...................................LLLLLCLTLCGV.CLNRGQPLPEGSEDRGRN......PLDDI..LQRSES.LILQSVLKKAEKGEAM.NKESNA...pL............PEWLSKRQHRGKKFLSD.LEKRQH.PGKR..D.VEE....D........TPYGNIQKRQH.PGKREIEd.........................dLD.GYM.ELK..KRQHP.GRRS....LP.DE.YADIPsAQLTYLNEISKRQHPGRRYL.....-MYKWQQ.PSKRGWND--....................EV..DL.ND...-QYGEKRQHSGKRHWNSDSLDD..AGPCNFQESF.TCNKGS..................
G1P8T9_MYOLU/6-207                   ...................................LLLALALTLTLT.GVPGGRAQLEVDQQEAAMaa.ehpALRDL..LRQAGHlLLLREDLQRLQGDQGN.RESESQi..fQ............SNGLSKRQHPGKR-EEE.AEE---.-GVE..D.EEE....E........GGAVGPHKRQH.PGPWENAa.........................aWS.VDV.TPQ..KRQHP.GRRS....--.--.-----.FWLGY--TFTKRQHPGRRLV.....-----DP.KAQRSWEEEE...................eEE..EE.EG...ELMPEKRQHPGKRAL-------..GGPCGLQGD-.-CGQAS..................
TRH_RAT/6-223                        ...................................LLLALALIFTLT.GIPESCALPEAAQEEGAVtp.dlpGLENV..QVRPER.RFLWKDLQRVRGDLGA.A-----....L............DSWITKRQHPGKREEEE.KD--IE.AEER..G.DLG....E........GGAWRLHKRQH.PGRRANQdkyswadeedsdw.mprswlpdffldsWF.SDV.PQV..KRQHP.GRRS....--.--.---FP.-W--MESDVTKRQHPGRRFI.....-----DP.ELQRSWEE--....................-K..EG.EG...VLMPEKRQHPGKRAL-------..GHPCGPQGT-.-CGQT-g.................
G1Q2W0_MYOLU/6-202                   ...................................LLLALALTLTLT.GVPGGRAQLEVDQQEAAMaa.ehpALRDL..LRQAGHlLLLREDLQRLQGDQGN.RESGS-....-............-NGLSKRQHPGKR-EEE.AEE---.-GVE..D.EEE....E........GGAVGPHKRQH.PGPWENAa.........................aWS.VDV.TPQ..KRQHP.GRRS....--.--.-----.FWLGY--TFTKRQHPGRRLV.....-----DP.KAQRSWEEEE...................eEE..EE.EG...ELMPEKRQHPGKRAL-------..GGPCGLQGD-.-CGQAS..................
G7PIM4_MACFA/6-207                   ...................................LLLALALTLNLT.GVPGGRAQPEAAQQEAVTaa.erpGLDDL..LRQVERvLFLRENIQRLQGDQGE.HSASQI...lQ............SDWLAKRQHPGKREEEE.EEG---.-VEE..E.EEE....E........AGAVGPHKRQH.PGRREDEa.........................sWS.VDV.TQH..KRQHP.GRRS....--.--.----P.-WLGY--AVTKRQHPGRRLT.....-----DP.KAQRSWEEEE...................eEE..ER.EE...ELMPEKRQHPGKRAL-------..GGPCGPQGA-.-CGQA-g.................
A6QM11_BOVIN/6-207                   ...................................FLLAMALTLTLT.GVPGGRAQLDVAQQEADLse..qqGLEDL..LRQAERlLLLREDLQRLREDQDD.SVSESQi..fQ............PDWFSKRQHPGKREEEE.ADE---.--AV..E.GEE....E........GGAAGLHKRQH.PGRRGDVa.........................aWA.VDA.GQQ..KRQHP.GRRA....--.--.-----.SWLGY--AVTKRQHPGRRLV.....-----DP.RAQRSWEEAG...................eDE..DE.GG...ELMSEKRQHPGKRAL-GSLCGP..RGPCG-----.------qasl..............
A0A093NQW3_PYGAD/7-227               ..................................p-LLLLCLTLCGV.CLNDGQPLPEGSENMGRS......TLDDI..LQRSES.IILQSVLKRAEKEDEM.DKESNA...pL............PEWLSKRQHPGKKYLSD.LEKRQH.PGKR..H.VEE....D........TSYGDIQKRQH.PGKREIEd.........................dLD.SYV.QLK..KQQHP.GRRS....LS.DQ.YADIPsAQLAYLNELSKRQHPGRRYL.....-MYKHQH.PSKRGWND--....................EV..DL.NN...-RYGEKRQHPGKRHWNSDSPDD..AGPCNFQDSF.TCNEGS..................
A0A1S3ENE1_DIPOR/6-122               ...................................LLLVLALTLTLT.SVPGGRAQPEAAQEEAALe...hpGLDAL..QRQAERlLLLREDLHRLRGDLGE.LSKSLVl..rR............LDRLSKRQHPGKRT-AA.VGG---.-GLEeaE.EEA....E........GGPVAPHKRQH.PGRRS--...........................--.---.---..-----.----....--.--.-----.--------------------.....-------.----------....................--..--.--...----------------------..----------.------pw................
A0A1B8XSL2_XENTR/6-214               ...................................WLLLLSTTLSQM.VHTQEQPLLEEDSA----......PADNLdvLEKAKG.ILIRSILEGFQEGQQN.KRAFPD....E............MEMISKRQHPGKRFQEE.LEKRQH.PGKR..D.LGD....-........-LNLELSKRQH.PGRRFLE...........................--.---.EIE..KRQHP.GKREegewSR.GY.RSDDS.SYLDLLSDVSKRQHPGKRIPd...pLFTKRQH.PGKREAEEED....................DT..EF.EI...SKEVAKRQHPGKRF--------..-DPCEGPNAY.NCNSG-n.................
A0A1D5R2T3_MACMU/1-164               ...................................------------.------------------......---DL..LRQVERvLFLRENIQRLQGDQGE.HSASQI...lQ............SDWLAKRQHPGKREEEE.EEG---.-VEE..E.EEE....E........AGAVGPHKRQH.PGRREDEa.........................sWS.VDV.TQH..KRQHP.GRRS....--.--.----P.-WLGY--AVTKRQHPGRRLA.....-----DP.KAQRSWEEEE...................eEE..ER.EE...ELMPEKRQHPGKRAL-------..GGPCGPQGA-.-CGQA-g.................
H2TW65_TAKRU/6-234                   ...................................LLILASVVVCNL.IVCGGQGIPDEDELDRM-......AIDDI.iLQRAEG.LLLQSILRKMQSEDGR.S-GESS....Q............IDWVTKRQHPGKRYMED.LEKRQH.PGRR..E.ESE....D........D--LDVQKRQH.PGKRDDE...........................MH.SLV.EIQ..RRQHP.GKRT....MM.GH.VTENP.--VLLFSELSKRQHPGKRYL....vLHTKRQH.PGKRHFEEEDidgew..........dadanAD..DV.ED...LAEPEKRQHPGKRFWDNSNPDLgtNNPCDVLDHT.SCSKTS..................
G3GS26_CRIGR/6-214                   ...................................LLLSLALIFTLT.GIPESCALPEAAQEEGAV......Q----..-MQPER.RFLRKDLQRVRGDLGA.A-----....L............DSWITKRQHPGKREEEE.ETE---.AEER..G.DLG....E........GGAWSPHKRQH.PGRRANQdkyswveaedsdwvsptrlphffleswYL.DQL.DQV..KRQHP.GRRS....--.--.---FP.---WMESDVTKRQHPGRRFI.....-----DP.NFQRSWED--....................KE..EG.EG...VPMPEKRQHPGKRAL-------..GQPCGPRGA-.-CGQT-d.................
A0A091WIM9_OPIHO/7-227               ..................................q-LLLLCLTLCGV.CLNGGQLLPEGSENMGRS......PFNDI..LQRSES.LILQSVLTKAEKEEEM.NKESNA...pL............PEWLSKRQHPGKKYLSD.LQKRQH.PGKR..D.VEE....D........PSYGGIQKRQH.PGKREIEd.........................nLD.GYL.ELK..KRQHP.GRRS....LT.DQ.YADVPsAQLTYLNDFSKRQHPGRRYL.....-MYKRQH.PSKRGWND--....................EV..DL.NP...-QYGEKHQHPGKRQWNSDSPDG..AGPCNFQESF.TCNKGS..................
H0ZJX5_TAEGU/7-224                   ..................................p-LLLLCLTSCGV.CFNGGHLLPEESENMGKV......PLDDT..LQRSES.LILQSVLKKAEKEEEI.NKELNA...pL............LQRLSKRQHPGEKYLNN.LKKRQH.PGKR..D.VEE....E........TFYGDIQKRQH.PGKREMEd.........................dLD.VYL.ELK..RQQPP.GIKS....LL.DQ.FAYSPrAQLTYMNELSKREHLGRRYL.....-MFKHQH.PSKRGWNY--....................EV..DV.YG...----EKRQHPGKRHWNFDRSDD..TGPCNFQESF.TCHKGS..................
R4GCM4_ANOCA/102-208                 ...............................gdgf------------.------------------......-----..------.----------------.------....-............-----------------.------.----..-.---....-........-----------.-------...........................-N.LYS.ELQ..KRQHP.GRRS....LW.EQ.YLNTPnSQLAYLNELSKRQHPGKRYL.....AYSKRQH.PGKRSWDE--....................--..ET.EE...VENLEKRQHPGKRYLSSESPDY..TAPCDLQDSL.ECSKGS..................
A0A218UDP5_9PASE/7-224               ..................................p-LLLLCLTLCGV.CFNGGHLLPEESENMGKI......PLDDI..LQRSES.LILQSVLKKAEKEEEI.NKESNA...pL............LQQLSKRQHPGKKYLNN.LEKRQH.PGKR..D.VEE....E........TFYGDIQKRQH.PGKREMEd.........................dLD.VYL.ELK..RQLPP.GRKS....LL.DQ.FAYSPrAQITYMNKLSKREHLGRRYL.....-MFKHQH.PSKRGWNY--....................EV..DV.YS...----EKRQHPGKRHWNFDRSDD..TGPCNFQESF.TCHKGS..................
T0M605_CAMFR/6-209                   ...................................FLLAMALTLTLT.GVPSGHAQPEMAQQEAAMaa.ehlDLDNL..LRQAERfLFLQEDLQRLREDQDQ.GDSDSEsqifQ............PDWFSKRQHPGKR-EEE.AED---.-GVE..E.EEE....E........GGAAGPHKRQH.PGRREDAa.........................aWL.VDV.TEQ..KRQHP.GRRS....--.--.-----.SWLGY--TFTKRQHPGRRLV.....-----DP.KAQRSWEEEE...................eEE..EE.AG...ELMPEKRQHPGKRAP-------..GGPCGPQGS-.-CGQTS..................
M7C513_CHEMY/5-225                   ..................................r-LLLLSLTFSSV.CVSLGQPIPEANENGDRS......HLDDI..LQRAES.IILRSILKTAEEGEET.NKETSA...pQ............PDWFSKRQHPGKRFPSD.LEKRQH.PGKR..E.DEE....E........VSYGETQKRQH.PGKREEDd.........................dLD.SDM.ELQ..KRQHP.GRRS....LW.DQ.YVDIPhTQLAYLNELSKRQHPGKRSL.....IYNKRQH.PGKRSWDD--....................GL..DL.GN...-QDLEKRQHPGRRYMDSESPDY..DAPCDRLDSF.NCSS--f.................
W5MZE0_LEPOC/103-245                 ................................ryp------------.------------------......-----..------.----------------.------....-............----------------D.FEKRQH.PGRR..E.EDD....-........-DYFEEQKRQH.PGKREDE...........................TD.DYV.ELQ..RRQHP.GKRS....LM.DQ.YSDATdSQMGYQSDMSKRQHPGKRYL.....SYNKRQH.PGRRELEN--....................EL..DA.GD...LQDLEKRQHPGKRYWDIKSPDYinNLPCDIKDPV.KCNKAS..................
F6QAC6_ORNAN/1-82                    .................................dd------------.------------------......-----..------.----------------.------....-............---LVKRQHPGKREEEE.EEE---.-GEE..S.DSE....E........ELLLEAQKRQH.PGRRDED..........................dSE.AFG.EWQ..KRQHP.GRRS....P-.--.-----.-WDRY--NVEKRQHPGKRYL.....-------.----------....................--..--.--...----------------------..----------.------d.................
A0A1S2ZCD1_ERIEU/6-148               ..................................w--LLLLVALDLM.GVPGVLAQPNMAQQEASMvadrpgVLNDL..LHQAER.LLLQADPQELQAEMDG.QWSDPQa..dQ............PHWLTKRQHPGRREEKE.VEE-VE.EEEE..E.TAA....A........GGAVGPHKRQH.PGRREQG...........................--.-DH.TPQ..KRQHP.GRRL....--.--.-----.--------------------.....-------.----------....................--..--.--...----------------------..----------.------anpeslgwg.........
A0A093IMU8_EURHL/7-227               ..................................p-LLLLCLTLCGT.CLSGGQPLPEGSENMGRS......PLDDI..LQRSES.LILQSVLKKAEKEEEM.NKESNV...pL............LEWLSKRQHPGKKYPSD.LEKRQH.PGKR..D.VEE....D........TFYGDIQKRQH.PGKREIEd.........................dLD.SYL.ELK..KRQHP.GRRS....LS.DQ.YADNPsAQLTYLNELSKRQHPGRRFL.....-MYNRQH.PSKRGWNE--....................EI..DL.ND...-QYYEKRQHPGKRYWNSDSPDD..GGPCNLQESI.TCNKGS..................
A0A094LDL2_9AVES/8-228               ...................................LLLLCCLTLCGV.CLNEGQPLLEGSENMGRS......PLDDI..LQRPES.LILQSVLKKAEKEEEM.NKESNA...pL............PKWLSKRQHPGKKYLSD.LEKRQH.PGKR..D.AEE....D........TSYGDIQKRQH.PGKRETEe.........................dLD.SYL.ELK..KRQHP.GRRS....LL.DQ.YADISnAKLTYLSELSKRHHPGRRYL.....-MYKHQH.PSKRGWDD--....................EV..DL.ND...-QHGEKRQHPGKRHGNSDTPND..TVPCNFQESL.ICNKGS..................
A0A093Q948_9PASS/7-227               ..................................p-LLLLCLTLWGV.CLNGRQPLPEESETTRRS......PLDDI..LQRSES.LIFQSVLKKAEKDEET.NKESKA...pL............SEWLSKRQHPGEKYLSK.LEKRQH.PGKR..D.VEK....D........TSYGDIQKRQH.PGKRETEd.........................nLD.VYL.ELK..KQQPP.GRRS....LL.DQ.IADSPrAQLTYMNELSKRQHPGRRYL.....-MYKHQQ.PSKRSWNY--....................EV..DL.ND...-QYGEKGQHPGKRHWNSDSSDD..TGPCNFLEFF.TCNKGS..................
Q1T735_ORYLA/6-232                   ...................................LLILASLAICNF.TVSDAQSISAEDETDRTT......TTDDI.iLRRAES.LLLRSLLKKMQDEDDI.NDGVYA....Q............QDWMAKRQHPGKRYRED.LEKRQH.PGRR..E.EDE....D........EEYLNAQKRQH.PGKREDE...........................IQ.SSM.GLQ..KRQHP.GKRF....LT.GH.ISDNP.--IIMLGELSKRQHPGKRYL....vLQSKRQH.PGKRYQDDEDsdg..............dweAA..EE.VD...LPELEKRQHPGKRFWDNSNPEL..GNPCDALEPD.NCSKTN..................
A0A091IU67_EGRGA/7-227               ..................................p-LLLLCLTLSAL.CLNGGQPLPEGSENMGRS......PLDDV..LKRSES.LILQPVLQKAEKEEEM.NKESNA...pL............PEWLSKRQHPGKKYLSD.LEKRQH.PGKR..N.TEE....D........TSYGDVQKRQH.PGKREIEd.........................dLD.GYL.ELK..KQQYP.GRRP....LL.DR.YAEIPsAQLAYLNELSKRQHPGRRYL.....-MYKRQH.PSKRGWNG--....................EV..DL.ND...-QYGEKRQHPGKRHWNSNSPDG..AGPCNFQESF.TCNKGS..................
A0A1S3MD66_SALSA/6-221               ...................................LIILASLAVCNL.TVARGQSIPAEEKTGDR-......QIDDI.iLQRAES.ILLRSILKMT--EDGV.NEALSS....Q............PEWLVKRQHPGKGYQEE.LEKRQH.PGKR..E.EDE....D........EDSREVQKRQH.PGKREDE...........................ID.SFV.ELQ..KRQHP.GKRS....ML.EQ.ITENS.---AFLSELSKRQHPGKRYL....mRYSKRQH.PGRRDVDD--....................ES..DA.GD...LQELEKRQHPGKRYWDNMSPDLgaNSPCDVLDP-.GCSKAN..................
K7E2N6_MONDO/150-189                 ................................vkd------------.------------------......-----..------.----------------.------....-............-----------------.------.----..-.---....-........-----------.-------...........................--.---.---..-----.----....--.--.-----.--------------------.....-------.----------....................--..--.-S...EEDVSKRQHPGKRNLDLDSQGS..AFPCSPRESS.HCS---l.................
A0A1U7V194_TARSY/33-178              ............................gvgaeps------------.------------------......-----..------.---------------T.DESQTL....Q............PDWLSKRQHPGRR-EEE.AEE---.-GVE..E.EEE...eE........GGAVGPRKRQH.PGRREDEa.........................sWL.VNA.TQH..KWQHP.GRHS....--.--.-----.SWLGY--AVTKRQHPGRRLV.....-----DP.KFQRSWEEEE...................eEE..ER.EE...ELVPEKRQHPGKRAL-------..GGPCGPQGT-.-CG---las...............
A0A091U920_PHORB/7-227               ..................................p-LLLLCLTLCGV.CLNEGQPLPEGRENMGSS......PLDDI..LQRSES.LILQSVLNKAEKEEEM.NKESNA...pL............PEWLSKRQHPGKKYLSD.LEKRQH.PGKR..E.VEE....D........TSYGDIQKRQH.PGKRETEe.........................dLD.GYL.ELK..KRQHP.GRRS....LS.DQ.YADIPsAKLTYLNELSKRQHPGRRYL.....-MYKHQH.PSKRGWNE--....................QV..DL.ND...-QYGEKRQHPGKRHWNSDSPDD..AGPCNFQESF.TCNKGS..................
G1SQS8_RABIT/7-210                   ...................................LLLALAWTLTLTgGVPGGRAQPESVHQEGATap.erpGLEEL..LRQAERlLLLREDLQRLRGDQGE.LPESQI...lQ............LDRLPKRQHPGKR-EEE.AEE---.-GVE..E.EEE...eE........GGAAGPHKRQH.PGRREDEa.........................sWA.ADG.TQH..KWQHP.GPRS....--.--.----P.-WLEY--AATKRQHPGRRMV.....-----DP.KVPRSWEEEEe..................eEE..EG.EG...ALMPEKRQHPGKRAL-------..GGPCGPRGA-.-CGE--ag................
H2QNC9_PANTR/6-205                   ...................................LLLALALTLNLT.GVPGGRAQPEAAQQEAVTav.ehpGLDDF..LRQVERlLFLRENIQRLQGDQGE.HSASQI...fQ............SDWLSKRQHPGKR-EEE.EEE---.-GVE..E.EEE....-........GGAGGPHKRQH.PGRREDEa.........................sWS.VDV.TQH..KRQHP.GRRS....--.--.----P.-WLAY--AVPKRQHPGRRLA.....-----DP.KAQRSWEEEE...................eEE..ER.EE...DLMAEKRQHPGKRAL-------..GGPCGPQGA-.-CGQA-g.................
A0A0A0ACE4_CHAVO/7-227               ..................................p-LLLLCLTLCSV.CLNGGQPLPEGNENLGRS......PLDDI..LQRSES.LILQSVLNKAEKEEEM.NKESNA...pL............PEWLSKRQHPGKKYLND.MEKRQH.PGKR..Y.VEE....D........TSYGDIQKRQH.PGKREIEd.........................dFD.GYL.ELK..KRQHP.GRRS....LS.DQ.YADIPgAQLTYLNELSKRQHPGRRYL.....-MYKRQH.PSKRGWND--....................EA..DL.ND...-QYGEKRQQPGKRHWSSDSPDD..AGPCNFHESF.TCNKGS..................
B5XBV3_SALSA/6-224                   ...................................LIILASLVVCNL.TLARGQGIPAEEETGDRQ......TIDDI.iLQRAES.LLLRSILKNIEDEDGA.NEGLTS....Q............PEWLVKRQHPGKRYQEE.LEKRQH.PGKR..E.EDE....D........EDYGVVQKRQH.PGKREDE...........................FD.SFV.ELQ..RRQHP.GKRL....ML.EQ.ITENP.---AFLSELSKRQHPGKRYM....mYYSKRQH.PGRREVDE--....................ES..DA.GD...LKELEKRQHPGKRYLDNTSPDLgaNSPCDVLDP-.GCSKAN..................
A0A1S2ZCD1_ERIEU/131-188             ...................................------------.------------------......-----..------.----------------.------....-............-----------------.------.----..-.---....-........-----------.-------...........................--.---.---..-----.----....--.--.-----.----------KRQHPGRRLA.....---NPES.LGWGVAE--E....................EG..RE.EG...EQEPEKRQHPGRRAL----GAL..DAPCGSRSA-.------cil...............
H2TW66_TAKRU/79-187                  ..................................g------------.------------------......-----..------.----------------.------....-............-----------------.------.----..-.---....-........-------KRQH.PGKRDDE...........................MH.SLV.EIQ..RRQHP.GKRT....MM.GH.VTENP.--VLLFSELSKRQHPGKRYL....vLHTKRQH.PGKRHFEE--....................-E..DI.DD...LAEPEKRQHPGKRFWDNSNPDL..----------.------dfldnisknh........
TRH_HUMAN/6-206                      ...................................LLLALALTLNLT.GVPGGRAQPEAAQQEAVTaa.ehpGLDDF..LRQVERlLFLRENIQRLQGDQGE.HSASQI...fQ............SDWLSKRQHPGKREEEE.EEG---.-VEE..E.EEE....E........GGAVGPHKRQH.PGRREDEa.........................sWS.VDV.TQH..KRQHP.GRRS....--.--.----P.-WLAY--AVPKRQHPGRRLA.....-----DP.KAQRSWEEEE...................eEE..ER.EE...DLMPEKRQHPGKRAL-------..GGPCGPQGA-.------ygqa..............
TRH_MOUSE/6-125                      ..................................l-MMALALIFVLT.GIPKSCALLEAAQEEGAVtp.dlpGLEKV..QVRPER.RFLRKDLQRVRGDLGA.A-----....L............DSWITKRQHPGKRE--E.KEEDVE.AEER..G.DLG....E........VGAWRPHKRQH.PGRRANQ...........................--.---.---..-----.----....--.--.-----.--------------------.....-------.----------....................--..--.--...----------------------..----------.------dkdswsde..........
M4AS06_XIPMA/6-234                   ...................................LLVLASFVICNL.AVCDGQGLPAEDEMDRST......TIDNL.mLQRAQS.LLLRSILKKLQDGDVR.NDGIFS....Q............PEWVTKRQHPGKRHFED.LEKRQH.PGRR..E.VVD....D........EQFWDMQKRQH.PGKREDE...........................MH.SFT.EFQ..KRQHP.GKRS....TT.GH.IPDSP.--VALLSELSKRQHPGKRYL....vLHSKRQH.PGKRLLEDEDdea..............dwtED..GE.ED...MSELEKRQHPGKRFWDNSSPELstSSPCDVLDSD.SCSKTS..................
L9JDC1_TUPCH/6-134                   ...............................llla--LAFALTLTLT.HIPGGRAQPEAAQQEEAMagadrpGLDDL..LRQAERlLFLREDLQRLQGNPGE.SPESPN...lQ............PDWLSKRQHPGKREEEE.EEG---.-AEE..E.EEE....D........RGAVAPHKRQH.PGRREE-...........................--.---.---..-----.----....--.--.-----.--------------------.....-------.----------....................--..--.--...----------------------..----------.------gappdrrwle........
G3NEZ6_GASAC/6-231                   ...................................LLALALLVVCNF.TVSGGQSIPAEDETGGR-......TIDDI.iLQRAES.LLLRSILKKIQDEDGG.DEGFPP....Q............AEWMTKRQHPGKRYGED.LEKRQH.PGRR..E.ADV....D........EPYLDVQRRQH.PGKREDE...........................MR.PFT.ELQ..KRQNP.GKRF....AA.GR.VSENP.--AVL--ELSKRQHPGKRYL....vVQTKRQH.PGKRDGDDDVdwd..............adgEG..GE.ED...LVEMEKRQHPGKRFWDTSSPDLgtNSPCDVLDPT.SCRKTS..................
A0A1S3ENE1_DIPOR/99-190              ..........................aeeeaeggp------------.------------------......-----..------.----------------.------....-............-----------------.------.----..-.---....-........-----------.-------...........................--.--V.APH..KRQHP.GRRS....--.--.----P.-WLSY--AVTKRQHPGRRLA.....--DPKDP.KGQRSWEEEE....................EEggDG.EG...ALVPEKRQHPGKRAL-------..EGPCGPPGA-.-C----rpag..............
F7HLL6_CALJA/6-91                    ...................................LLLALALTLNLI.GVPGGRAQPEAAQQEAVTaa.erpGLNDL..LRQAERlLFLRENILRLQGDQGE.HSASQI...lQ............PDWLSKRQHPGKK----.------.----..-.---....-........-----------.-------...........................--.---.---..-----.----....--.--.-----.--------------------.....-------.----------....................--..--.--...----------------------..----------.------ga................
A0A2D0QYL3_ICTPU/3-212               ...............................avcl-LVLVSLA---V.FSIQCQNVPSDSGGE-NP......TLDEV..LQRAEG.QLLRSFLQNQQDNESS.NDLFPV....P............PDWLVKRQHPGKR----.----QH.PGKR..D.EDDdddeE........EEYAELQKRQH.PGKREDA...........................SD.LFV.ALQ..RRQHP.GRRS....EL.EG.QT--S.VQSDLLSEFSKRQHPGKRYD.....AYDKRQH.PGRRDAEE-G....................AA..SS.VD...LWELDKRQHPGKRSWDPSEVSS..GSPCDVPG--.-CSK--as................
A0A2K5HPM3_COLAP/6-207               ...................................LLLALALTLNLT.GVPGGRAQPEAAQQEAVTaa.erpGLDDL..LHQVERvLFLRENIQRLQGDQGE.HSASQI...lQ............SDWLSKRQHPGKREEEE.EEG---.-VEE..E.EEE....E........GGAVGPHKRQH.PGRREDEa.........................sRS.VDV.TQH..KRQHP.GRRS....--.--.----P.-WLGY--AVAKRQHPGRRLA.....-----DP.KAQRSWEEEE...................eEE..ER.EE...ELMPEKRQHPGKRAL-------..GGPCGPQGA-.-CGQA-g.................
A0A2G9RV07_LITCT/99-208              ................................egd------------.------------------......-----..------.----------------.------....-............-----------------.------.----..-.---....-........-----------.-------...........................--.LYL.ELP..KRQHP.GRRS....FFgDQ.LLDNSnPPLGLLSDISKRQHPGKRGL.....AYAKRQH.PGKRGWDEEE....................DM..DF.GD...FQEVDKRQHPGKRYTEPENVDY..VPPCEGPDPF.NCSKGS..................
TRH_DANRE/68-175                     ...................................------------.------------------......-----..------.----------------.------....-............-----------------.------.----..-.---....-........-------KRQH.PGKREED...........................LE.PEV.EMErwRRQHP.GKRA....PL.DLgMLEDP.---TALSELSKRQHPGKRYL....mLLHKRQH.PGRRELQEA-....................--..-D.GD...SAELEKRQHPGKRRC-------..----------.------egwadagcgllelldt..
H2TW67_TAKRU/6-220                   ...................................LLILASVVVCNL.IVCGGQGIPDEDELDRM-......AIDDI.iLQRAEG.LLLQSILRKMQSEDGR.S-GESS....Q............IDWVTKRQHPGKRYMED.LEKRQH.PGRR..E.ESE....D........D--LDVQKRQH.PGKRDDE...........................MH.SLV.EIQ..RRQHP.GKRT....MM.GH.VTENP.--VLLFSELSKRQHPGKRYL....vLHTKRQH.PGKRHFED--....................--..DV.ED...LAEPEKRQHPGKRFWDNSNPDLgtNNPCDVLDHT.SCSKTS..................
G1QZG4_NOMLE/6-207                   ...................................LLLALALTLNLT.GVPGGRAQPEVAQQEAVTaa.erpGLDDF..LRQVERlLFLRENIQRLQGDQGE.HSASQI...lQ............SDWLSKRQHPGKREEEE.EEG---.-VEE..E.EEE....E........AGAVGPHKRQH.PGRREDEa.........................sWS.VDV.TQH..KRQHP.GWRS....--.--.----P.-WLGY--AVLKRQHPGRRLA.....-----DP.KAQRSWEEEE...................eEE..ER.EE...DLMPEKRQHPGKRAL-------..GGPCGPQGA-.-CGQA-g.................
F1QKW8_DANRE/68-177                  ...................................------------.------------------......-----..------.----------------.------....-............-----------------.------.----..-.---....-........-------KRQH.PGKREED...........................LE.PEV.EMErwRRQHP.GKRA....PL.DLgMLEDP.---TALSELSKRQHPGKRYL....mLLHKRQH.PGRRELQEAD....................--..--.GH...SAELEKRQHPGKRRC-------..----------.------egwadagcgllelldtsg
I3KKT6_ORENI/6-235                   ...................................LLILASLTVCNL.MVSGGQSMSAEDETDRK-......TIDDI.iLERAET.LLLRSILKKLQDEDGR.NDGYYS....Q............PEWVTKRQHPGKRYSDD.LEKRQH.PGRR..E.EDE....D........EQYFDVQKRQH.PGKREDE...........................TH.SFL.EPQ..KRQHP.GKRS....TA.GH.SSDNP.--ILLLSELSKRQHPGKRYL....vLHSKRQH.PGKRLLEDEDgdrd............wdadAD..GE.ED...LAEMEKRQHPGKRFWDNSSADLgtNSPCDVLDPA.SCSKTS..................
H3AN56_LATCH/7-227                   ...................................LLLLVSLGLSSM.TAVLGQHAPEGVESEESV......PMDDL..LQQAES.ILLRSILKKMEEEKDL.HDPTAS....Q............VEWISKRQHPGKRFQAE.LEKRQH.PGKR..D.EDE....E........IAYIEAQKRQH.PGKRGGE..........................gLD.EYT.EVQ..KRQHP.GRRS....TL.DQ.FTDSPnTQLAFLSELSKRQHPGKRYL.....LYNKRQH.PGKRGWDK--....................EL..DY.ED...LQELEKRQHPGKRQLPPESPDY..GLPCDILDPI.NCSKTS..................
A0A1U7RQM3_ALLSI/6-227               ...................................LLLLLSLTLSGI.CLNLGQPTLDGGENGERS......HLDDI..LQRAES.ILLRSILKKVEEEEEL.NKEPDA...sE............PDSLSKRQHPGKRFFNE.LEKRQH.PGKR..E.DGE....E........ALYGDIQKRQH.PGKREEDd.........................dLD.HYL.ELQ..KRQHP.GKRS....LW.DQ.YVDAPgTQLTYLNELSKRQHPGKRYL.....VYAKRQH.PGKRGWED--....................EL..DL.GE...-QDLEKRQHPGKRFSDSESPDY..AAPCDLQDDF.NCSKGS..................
A0A226PNL5_COLVI/13-244              ..................................p-VLLLCLTLSGV.CLNGRQSPPEASENMRS-......SLDDI..SQRSGS.HMLQSVLKKVEKKEEM.NKGIYSt.gdNplyillyslaeiIRWLYKRQHPGKRYVSD.LEKRQH.PGKR..D.AEE....E........TSYADIQKIQH.LGKTEDY...........................LA.NYP.ELK..KRQHP.GRRS....LW.DQ.STGIPsSQLTYLNELSKTQHAGRRYL.....-MYKHQH.PSKRGWND--....................EL..DL.SG...-QNWEKHQHSRKRHRDSGSLDY..AGPCDLQQSA.ICNKSS..................
R0K990_ANAPL/7-227                   ..................................p-LLLLCLTLSGV.CLNGGQPLPEASENMGRR......PLDNI..LQRSES.FILQSVLKKAEKKEEM.NKELNA...pL............PEWLSKRQHPGKRYISD.LEKRQH.PGKR..D.VKE....E........ASYGDIQKRQH.PGKREVEd.........................dLA.SYL.ELK..KRQHP.GRRS....LW.DQ.HVDIPsARLTYLNVLSKRQHPGRGYL.....-MHKHQH.PSKRGWND--....................EL..DI.SD...-HDGEKRQHPGKRHWDTDNPDY..AGPCDLQESS.TCNTGS..................
G5C711_HETGA/112-178                 ................................rsp------------.------------------......-----..------.----------------.------....-............-----------------.------.----..-.---....-........-----------.-------...........................--.---.---..-----.----....--.--.-----.-WLEY--VVTKRQHPGRRLV.....-----DL.RSQRSWQEED...................vEE..DR.EG...-PIPKKRQHPGKRAP-------..GEPCGPQGA-.-CDQAS..................
TRH_CHICK/7-227                      ..................................p-VLLLCLTLSGV.CLNGRQFPPELSENMGRS......SLDDI..LQRSGS.HMLQSVLKKVEKKEEM.NKELNM...pL............PQWLSKRQHPGKRYISD.PEKRQH.PGKR..D.VEE....K........ASFGDIQKRQH.LGKTEVEg.........................yLV.NYL.ELK..KRQHP.GRRS....LW.DQ.STDISsSQLTYLNELSKRQHPGRRYL.....-MYKHQH.PSKRGWND--....................EL..DL.SD...-QNWEKHQQFGNRDRDSDSPDY..TGPCDLQQSA.ICNKD-s.................
A0A2I2YDN3_GORGO/6-207               ...................................LLLALALTLNLT.GVPGGRAQPEAAQQEAVTaa.ehpGLDDF..LRQVERlLFLRENIQRLQGDQGE.HSASQI...fQ............SDWLSKRQHPGKREEKE.-EE---.-GVE.eE.EEE....E........GGAVGPHKRQH.PGRREDEa.........................sWS.VDV.TQY..KRQHP.GRRS....--.--.----P.-WLAY--AVPKRQHPGRRLA.....-----DP.KSQRSWEEEE...................eEE..ER.EE...DLMPEKRQHPGKRAL-------..GGPCGPQGA-.-CGQA-g.................
M3WV29_FELCA/45-241                  ...................................LLLALALTLTVA.GIPGGRAQLEVAQHEAGEh....aGLDDL..LRQAERlLLLQEDLLRLRGNQDD.GESESQi..iQ............PDWLSKRQHPGKREEEE.AED---.-GVE..E.EEE....-........GGAMGPHKRQH.PGRREDV..........................aAW.SEV.TQQ..KRQHP.GRRS....--.--.-----.SWLGY--TFTKRQHPGRRLV.....-----DP.KAQRSWEEEE....................EE..VE.EG...ELMPEKRQHPGKRAL-------..GGPCEPQGA-.-CGQAS..................
A0A087Y6U4_POEFO/6-234               ...................................LLVLASFVICNL.AVCDGQGLPAEDEMDRST......TIDNL.mLQRAQS.LLLRSILKKLQDGDGK.NDGILS....Q............PQWVTKRQHPGKRYFED.LEKRQH.PGRR..E.VVD....D........EQFWDMQKRQH.PGKREDE...........................MH.SFT.EFQ..KRQHP.GKRS....TT.GH.IPDSP.--VVVLSELSKRQHPGKRYL....vLHSKRQH.PGKRLFEDEDgea..............dwtED..GE.ED...MTELEKRQHPGKRFWDNSSPELstSSPCDVLDSD.SCSKTS..................
A0A091IDK5_CALAN/7-227               ..................................p-LLLLCLTLCGV.CLSGEQPLPEASENMKRS......PLDDI..LQRSQS.LFLQSFLKKAEKKEDI.NKESDA...pL............PEWLAKRQHPGRKFLSD.LEKRQH.PGKR..D.AEE....E........KPYGDIHNWQH.PGKREIEd.........................dLN.SYL.ELK..KRQHP.GRRS....VL.EQ.YADISsAQLTYLNEISKRQHPGRRYL.....-MYKHQH.PRKRGWNV--....................EA..DL.ND...-QYGEEHQHAGKRDWNSDSPDD..ASPCHFQDSS.TSSKGS..................
#=GC seq_cons                        ....................................LLhlsLsLshh.slstGps.P-tspp.tt.......sLDDl..LppuEp.LlLppsLp+hpt-pt..ppt.p..................s-WLoKRQHPGKR..p-.hEc.....Gcc..-..-E....-........sshhs.pKRQH.PG+REt-...........................ht.s.h.p.p..KRQHP.GRRS..............s...LsY..ploKRQHPGRRhl..........p...upRuWp-......................E...-h.ps......sEKRQHPGKRth.........suPCs.tts...Csps...................
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