#=GF ID TTc_toxin_rep
#=GF AC PF18807.2
#=GF DE Tripartite Tc toxins repeat
#=GF AU Paladin L;0000-0003-0011-9397
#=GF AU Piovesan D;0000-0001-8210-2390
#=GF SE RepeatsDB
#=GF GA 29.00 25.00;
#=GF TC 29.90 27.20;
#=GF NC 28.80 23.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 24572368
#=GF RT Mechanism of Tc toxin action revealed in molecular detail.
#=GF RA Meusch D, Gatsogiannis C, Efremov RG, Lang AE, Hofnagel O,
#=GF RA Vetter IR, Aktories K, Raunser S;
#=GF RL Nature. 2014;508:61-65.
#=GF DR INTERPRO; IPR041508;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Tripartite Tc toxin complexes of bacterial pathogens perforate
#=GF CC the host membrane and translocate toxic enzymes into the host
#=GF CC cell. These structures undergo a transition between a prepore to
#=GF CC a pore state [1] and they are mainly constituted by closed
#=GF CC beta-layer repeats. This Pfam entry includes a single repeat
#=GF CC unit.
#=GF SQ 60
#=GS Q7N7Y4_PHOLL/424-468 AC Q7N7Y4.1
#=GS L1M7U2_PSEPU/425-469 AC L1M7U2.1
#=GS T0PBV8_PHOTE/412-456 AC T0PBV8.1
#=GS A0A3N1J6A9_9ENTR/414-458 AC A0A3N1J6A9.1
#=GS T0P160_PHOTE/425-469 AC T0P160.1
#=GS Q0WAX9_YERPE/411-455 AC Q0WAX9.1
#=GS D3VFD3_XENNA/420-464 AC D3VFD3.1
#=GS W1J3J6_9GAMM/422-466 AC W1J3J6.1
#=GS A0A2X4TMW6_SALER/422-466 AC A0A2X4TMW6.1
#=GS W1J412_9GAMM/431-475 AC W1J412.1
#=GS Q7MZ20_PHOLL/416-460 AC Q7MZ20.1
#=GS A0A0L0M000_9BURK/375-419 AC A0A0L0M000.1
#=GS M1SJJ1_MORMO/70-114 AC M1SJJ1.1
#=GS T0NYT3_PHOTE/425-468 AC T0NYT3.1
#=GS M1SR07_MORMO/421-465 AC M1SR07.1
#=GS D3VGF9_XENNA/433-482 AC D3VGF9.1
#=GS H2J1R8_RAHAC/432-476 AC H2J1R8.1
#=GS A0A2S0PAL3_9NEIS/425-470 AC A0A2S0PAL3.1
#=GS C7BMY6_PHOAA/412-456 AC C7BMY6.1
#=GS D3V0Q1_XENBS/423-467 AC D3V0Q1.1
#=GS A0A089YU68_9PSED/417-461 AC A0A089YU68.1
#=GS C7BMQ9_PHOAA/420-464 AC C7BMQ9.1
#=GS E5AU94_PARRH/1847-1891 AC E5AU94.1
#=GS A0A014NAG0_9GAMM/431-475 AC A0A014NAG0.1
#=GS A0A0T9KXI6_9GAMM/422-466 AC A0A0T9KXI6.1
#=GS T0QFH4_PHOTE/416-460 AC T0QFH4.1
#=GS A0A3N1I575_9ENTR/413-457 AC A0A3N1I575.1
#=GS Q7N7Z1_PHOLL/412-456 AC Q7N7Z1.1
#=GS C7BJB9_PHOAA/426-470 AC C7BJB9.1
#=GS A0A2S0P8T4_9NEIS/420-464 AC A0A2S0P8T4.1
#=GS A0A2V2YWD9_9BACL/1659-1697 AC A0A2V2YWD9.1
#=GS W1IQG7_9GAMM/426-470 AC W1IQG7.1
#=GS Q7N7Y7_PHOLL/417-461 AC Q7N7Y7.1
#=GS T0NXK1_PHOTE/420-464 AC T0NXK1.1
#=GS A0A0T9LI51_9GAMM/431-475 AC A0A0T9LI51.1
#=GS A0A2S0PDD9_9NEIS/395-439 AC A0A2S0PDD9.1
#=GS A0A089YQU6_9PSED/422-466 AC A0A089YQU6.1
#=GS A0A2D0KBY3_9GAMM/434-478 AC A0A2D0KBY3.1
#=GS A0A2Z6EY43_9BURK/426-470 AC A0A2Z6EY43.1
#=GS A9MLT1_SALAR/422-466 AC A9MLT1.1
#=GS W1J1L4_9GAMM/432-476 AC W1J1L4.1
#=GS A0A0T9KX35_9GAMM/432-476 AC A0A0T9KX35.1
#=GS Q7MZV7_PHOLL/425-469 AC Q7MZV7.1
#=GS Q0WAX8_YERPE/479-523 AC Q0WAX8.1
#=GS A0A1X1DCG1_9GAMM/362-406 AC A0A1X1DCG1.1
#=GS A0A2A2HMI0_9GAMM/48-92 AC A0A2A2HMI0.1
#=GS A0A2Z6EY71_9BURK/428-472 AC A0A2Z6EY71.1
#=GS A0A1X1DDL8_9GAMM/432-476 AC A0A1X1DDL8.1
#=GS Q0WEK9_YERPE/432-476 AC Q0WEK9.1
#=GS A0A2S0PD28_9NEIS/420-464 AC A0A2S0PD28.1
#=GS A0A103EJW6_9BURK/239-287 AC A0A103EJW6.1
#=GS L1M7J5_PSEPU/427-471 AC L1M7J5.1
#=GS Q7MZU2_PHOLL/419-463 AC Q7MZU2.1
#=GS H2ISD9_RAHAC/432-476 AC H2ISD9.1
#=GS D3V3H9_XENBS/414-458 AC D3V3H9.1
#=GS A0A0H2W6I4_YERPE/429-473 AC A0A0H2W6I4.1
#=GS H2IRT0_RAHAC/405-449 AC H2IRT0.1
#=GS A0A2Z6EYD0_9BURK/428-472 AC A0A2Z6EYD0.1
#=GS Q7N7X5_PHOLL/420-464 AC Q7N7X5.1
#=GS D3VHI0_XENNA/422-466 AC D3VHI0.1
Q7N7Y4_PHOLL/424-468 ...QNNYTTNITVSHQSNRAVLSTLTE.....DPTQVDA..LFDAGGHQNTLIAG..
L1M7U2_PSEPU/425-469 ..a-SSHSVEITVSERSNRALLASLAG.....NPQEVEA..LFSAAGAQRCLQPG..
T0PBV8_PHOTE/412-456 ...QNNYTTDITISNRSNRGVLSTLTT.....DPSKVDA..LFDAGGHQTSLLPG..
A0A3N1J6A9_9ENTR/414-458 ..g-SGYTTDITVSDRSNKAVLSTLTT.....KPAEVDA..LFTAGGQQKQLLQG..
T0P160_PHOTE/425-469 ...QNNYTTDMTVSSRSNRAVLSTLTT.....DPTQVDA..LFDSGGHQKTLMPG..
Q0WAX9_YERPE/411-455 ..a-SQYSTHITVSDSSNHGIQQQDGI.....IARDIRS..QFDAAGNQQQLQPG..
D3VFD3_XENNA/420-464 ...QNNHTINITVSNRTNRGVLSSLTD.....DPNKVDA..LFNAGGQQINLLPG..
W1J3J6_9GAMM/422-466 ...GNNYTTNMTVSDYSNRAVLEALAE.....DPAKVDM..LFTPGGHQTRLVPG..
A0A2X4TMW6_SALER/422-466 ...GNCHTTYITVSDSSNRAVLRSLAA.....TPAEVEM..HFGPSGEQLQLQPG..
W1J412_9GAMM/431-475 ...GNSYTTQITVSDRSNRAVLNLLAE.....DTTKVDA..LFDAGGHQSQLLPG..
Q7MZ20_PHOLL/416-460 ...NNNYTTNITISNRNNRGVLSTLTN.....DPNLVDT..FFDAGGHQTSLFSG..
A0A0L0M000_9BURK/375-419 ...NNRYTTDITVSDRSNRGVLSTLTE.....NRSAVDG..LFTASGQQKQLQPG..
M1SJJ1_MORMO/70-114 ...GNNHTTDITVSQRSNRAVLKTLAD.....TPEKAEA..LFTPGGQQTQLQPG..
T0NYT3_PHOTE/425-468 ...QNNHTRGITVSNRSNRAVLSMLTD.....KPEEVDS..WFDAGGHQKTLH--r.
M1SR07_MORMO/421-465 ...NNNYTTDITVSQRSNRAVLKTLAD.....TPEKAEA..LFTPGGQQTQLQPG..
D3VGF9_XENNA/433-482 ...GNNWTTDIAISTTANRGVSTALFTditpqNPEQVDT..LFDRAGNQLQLQPG..
H2J1R8_RAHAC/432-476 ...NNNYTQAITVSDRSNRGVSGTLAE.....IPSQVDA..SFTAGGQQKYLQPG..
A0A2S0PAL3_9NEIS/425-470 .av--SFTQDFVVSARSNRSVLQTATG....iDPGAVDA..LFDAQGNPATLSTG..
C7BMY6_PHOAA/412-456 ...QNSYTKDITVSNRSNRGVLSTLTT.....DRNKVDT..LFDAGGHQTSLLPG..
D3V0Q1_XENBS/423-467 ..d-NSYTTKMTVSDRSNRAVLSTLTE.....NPAEVDA..LFTTGGQQNQLLPG..
A0A089YU68_9PSED/417-461 ..g-AGFITELTTSTRSNRTLPSSLCD.....DPSQIDD..HFDAAGQQRALDH-s.
C7BMQ9_PHOAA/420-464 ..k-GSYTKRITVSNRSNRAVPSELTD.....NPMQVDT..LFDAGGNQNTLTPG..
E5AU94_PARRH/1847-1891 .aq--HYTLRMVVAAGSNRAVPEAWDA.....APEQVDR..YFDANGNLTQLQPG..
A0A014NAG0_9GAMM/431-475 ...GNNYTTKITVSDRSNRAVLSSLVA.....RAEEVDA..LFTNRGCQTELVSG..
A0A0T9KXI6_9GAMM/422-466 ...NNSYTTNITVSKYSNRAVLSSLTD.....DADKVEG..FFDAAGRQNQLLPG..
T0QFH4_PHOTE/416-460 ...QNDYTTNITVSNRSNHAVLNLLTT.....DPTQVDT..LFDAGGHQKKLLPG..
A0A3N1I575_9ENTR/413-457 ...GNNYTADITVSNRSNRAVLSTLTK.....NPAEVDV..LFTAGGQQKQLSPG..
Q7N7Z1_PHOLL/412-456 ...QNNYTTAITISNRSNRGVLSTLTT.....DPNQVDT..LFDAGGHQTSLLPG..
C7BJB9_PHOAA/426-470 ...HNIYTTEITVSNRSNRAVLSHNGL.....TPREVDA..QFDASGHQISLPTG..
A0A2S0P8T4_9NEIS/420-464 ..a-SAYTLAMIVAQTSNRAVRQTGDL.....TPADIDG..LFDACGNLLQLQPG..
A0A2V2YWD9_9BACL/1659-1697 .tr----TLSLTVSSCSNRAVPSSQTM.....DAAQVDA..LFDASGCL------kq
W1IQG7_9GAMM/426-470 ...RNNHATSLTVSSRNNRAVLSAFTT.....DPEQVDT..WFDAGGHQTSLLPG..
Q7N7Y7_PHOLL/417-461 ...QNNYTTNITVSNYSNRAVLSTLTE.....DPTQVDA..LFDSGGHQTNLLSG..
T0NXK1_PHOTE/420-464 ...QGSYTTQITVSNRSNRAVWSTLTD.....NPMLVDD..LFDAGGHQNTLVQG..
A0A0T9LI51_9GAMM/431-475 ..r-SGYTTNITVSNRSNRAVLSTLTE.....NAADVDA..LFTVGGQQAQLQPG..
A0A2S0PDD9_9NEIS/395-439 sqp---YTLAMVVSSTSNRTLQQSDGL.....TPADVDA..GFDAAGQLLALAAG..
A0A089YQU6_9PSED/422-466 ...GNDFTLDMTVARTSNRAVISDMCA.....DPEQVDD..CFLAAGQQKRLPEG..
A0A2D0KBY3_9GAMM/434-478 ...NNCYTTNFTVSNRSNRSVLNTLTK.....EISEVDA..LFDGSGHQKQMQPG..
A0A2Z6EY43_9BURK/426-470 ...GNNYTTEITVSDRSNRAVLSQPGL.....TPGEVDV..LFDAGGHQKSLQPG..
A9MLT1_SALAR/422-466 ...GNCHTTYITVSDSSNRAVLRSLAA.....TPAEVEM..HFGPSGEQLQLQPG..
W1J1L4_9GAMM/432-476 ...GNNYTTTVTVSNRSNRAVLSTLTE.....NPADVDM..LFNANGSQRQLQPG..
A0A0T9KX35_9GAMM/432-476 ...NNNYTLNITLSERSNRGVISSLTE.....NPADVDA..LFSASGNPKWLQHG..
Q7MZV7_PHOLL/425-469 ...QNSYTTEMTVSSRSNRTVLSTLTT.....DPTQVDG..LFDAGGHQKTLIPG..
Q0WAX8_YERPE/479-523 ..a-SQYSTHITVSDSSNHGIQQQEGI.....TARDIRS..QFDAAGNQQQLQPG..
A0A1X1DCG1_9GAMM/362-406 ...NNCYTKNFTISNHSNRGVLSTLTE.....NPEEVDA..LFTAGGQQSWLMPG..
A0A2A2HMI0_9GAMM/48-92 ...NNNYTVNITVSDRTNRAVLSSLTE.....DPTMVDR..LFTSGGQQQQLLSG..
A0A2Z6EY71_9BURK/428-472 ...NNNYTTDITVSDRSNRAVLSQPGL.....TPGGVDA..LFDAGGNQKSLLPG..
A0A1X1DDL8_9GAMM/432-476 ...GNSYTTDITISNRSNRGVLSTLTK.....NPSDVDT..LFTVSGQQKQLQPG..
Q0WEK9_YERPE/432-476 ...NNSYTTKITVSDRSNRGVLSTLTE.....NAADVDA..LFTAGGQQTKLQPG..
A0A2S0PD28_9NEIS/420-464 .nq--PYTLAMVVSSTSNRTLQQSDGL.....TPADVDA..GFDAAGQLLALAAG..
A0A103EJW6_9BURK/239-287 .av--NYTQEIVVSDRSNHALQQNATGt...lTPAGVDDgsWFDASGNQRMLLP-d.
L1M7J5_PSEPU/427-471 ...GNNYTLEHTLSERSCRGVPNALAS.....DPAQVEA..LFTPGGQQRLLQPG..
Q7MZU2_PHOLL/419-463 ...QNNYTTDITVSNRSNRAVLSTLTT.....DPTKVDA..LFQAGGHQETLLPG..
H2ISD9_RAHAC/432-476 ...NNNYTTSITISDRTNRGVLSTLTG.....ESSEVDA..LFTARGVQKQLQPG..
D3V3H9_XENBS/414-458 ...NNNYTLNITVSNRNNHAVSQDLAE.....KPEQVDA..QFDAGGHQMNLIPG..
A0A0H2W6I4_YERPE/429-473 ..g-SGHTTDITVSDRSNQGVLSTLTT.....NPAEVDA..LFTAGGQQKQLQPG..
H2IRT0_RAHAC/405-449 .eq--NFTQQTVIATNNNRALLQTGDV.....KPEDVDD..SFDATGNILMLQPG..
A0A2Z6EYD0_9BURK/428-472 ...NNNYTTDITVSNRSNRAVLSQPGL.....MPDGVDA..LFDAGGHQKSLLPG..
Q7N7X5_PHOLL/420-464 ...QNNYTTDITVSNRSNHAVLNSLTT.....DPTQVDT..LFDAGGHQKKLLPG..
D3VHI0_XENNA/422-466 ...GNNYTTNMTVSDHSNRAVLEELAQ.....DPTQVDM..LFTPGGHQTRLVPG..
#=GC seq_cons ...tNsYTTsITVSsRSNRAVLSoLsp.....sPspVDu..LFsAuGpQppL.PG..
//
