#=GF ID TTc_toxin_rep
#=GF AC PF18807.6
#=GF DE Tripartite Tc toxins repeat
#=GF AU Paladin L;0000-0003-0011-9397
#=GF AU Piovesan D;0000-0001-8210-2390
#=GF SE RepeatsDB
#=GF GA 29.00 25.00;
#=GF TC 29.30 27.60;
#=GF NC 28.70 23.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 81514348 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 24572368
#=GF RT Mechanism of Tc toxin action revealed in molecular detail.
#=GF RA Meusch D, Gatsogiannis C, Efremov RG, Lang AE, Hofnagel O,
#=GF RA Vetter IR, Aktories K, Raunser S;
#=GF RL Nature. 2014;508:61-65.
#=GF DR INTERPRO; IPR041508;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Tripartite Tc toxin complexes of bacterial pathogens perforate
#=GF CC the host membrane and translocate toxic enzymes into the host
#=GF CC cell. These structures undergo a transition between a prepore to
#=GF CC a pore state [1] and they are mainly constituted by closed
#=GF CC beta-layer repeats. This Pfam entry includes a single repeat
#=GF CC unit.
#=GF SQ 47
#=GS A0A2S0PAL3_9NEIS/426-470 AC A0A2S0PAL3.1
#=GS A0A089YQU6_9PSED/422-466 AC A0A089YQU6.1
#=GS A0A2S0PD28_9NEIS/419-464 AC A0A2S0PD28.1
#=GS A0A2S0P8T4_9NEIS/420-464 AC A0A2S0P8T4.1
#=GS A0A077PQ26_XENBV/422-466 AC A0A077PQ26.1
#=GS M1SR07_MORMO/421-465 AC M1SR07.1
#=GS A0A2U8I357_9GAMM/416-460 AC A0A2U8I357.1
#=GS M1SJJ1_MORMO/70-114 AC M1SJJ1.1
#=GS A0A1D8TQN2_9CYAN/1862-1902 AC A0A1D8TQN2.1
#=GS H2ISD9_RAHAC/432-476 AC H2ISD9.1
#=GS Q7N7Y4_PHOLL/424-468 AC Q7N7Y4.1
#=GS A0A077PFE7_XENBV/425-467 AC A0A077PFE7.1
#=GS W1J1L4_9GAMM/432-476 AC W1J1L4.1
#=GS Q7N7Y7_PHOLL/417-461 AC Q7N7Y7.1
#=GS Q7N7X5_PHOLL/420-464 AC Q7N7X5.1
#=GS A0A089Q1C3_9ENTR/428-472 AC A0A089Q1C3.1
#=GS D3VHI0_XENNA/422-466 AC D3VHI0.1
#=GS A0A2Z6EYD0_9BURK/428-472 AC A0A2Z6EYD0.1
#=GS Q0WEK9_YERPE/432-476 AC Q0WEK9.1
#=GS A0A380SCC3_YERPE/429-473 AC A0A380SCC3.1
#=GS A0A4P7KQ39_9GAMM/432-468 AC A0A4P7KQ39.1
#=GS A0A2Z6EY71_9BURK/428-472 AC A0A2Z6EY71.1
#=GS A0A2A2HMI0_9GAMM/48-92 AC A0A2A2HMI0.1
#=GS W1J412_9GAMM/431-475 AC W1J412.1
#=GS W1J3J6_9GAMM/422-466 AC W1J3J6.1
#=GS D3VFD3_XENNA/420-464 AC D3VFD3.1
#=GS Q7N7Z1_PHOLL/412-456 AC Q7N7Z1.1
#=GS Q0WAX8_YERPE/479-523 AC Q0WAX8.1
#=GS A0A3B0J4V9_9GAMM/172-216 AC A0A3B0J4V9.1
#=GS A0A2X4TMW6_SALER/422-466 AC A0A2X4TMW6.1
#=GS A0A3D9UFP2_9GAMM/426-470 AC A0A3D9UFP2.1
#=GS H2J1R8_RAHAC/432-476 AC H2J1R8.1
#=GS A0A014NAG0_9GAMM/431-475 AC A0A014NAG0.1
#=GS A0A077PIY4_XENBV/414-458 AC A0A077PIY4.1
#=GS A9MLT1_SALAR/422-466 AC A9MLT1.1
#=GS Q7MZV7_PHOLL/425-469 AC Q7MZV7.1
#=GS Q7MZ20_PHOLL/416-460 AC Q7MZ20.1
#=GS A0A2V2YWD9_9BACL/1659-1699 AC A0A2V2YWD9.1
#=GS A0A947DCR3_9CYAN/1823-1873 AC A0A947DCR3.1
#=GS A0A089YU68_9PSED/417-461 AC A0A089YU68.1
#=GS A0A2Z6EY43_9BURK/426-470 AC A0A2Z6EY43.1
#=GS Q7MZU2_PHOLL/419-463 AC Q7MZU2.1
#=GS W1IQG7_9GAMM/426-470 AC W1IQG7.1
#=GS A0A077PIS5_XENBV/423-467 AC A0A077PIS5.1
#=GS D3VGF9_XENNA/433-482 AC D3VGF9.1
#=GS A0A239EU47_9PSED/408-452 AC A0A239EU47.1
#=GS A0A239HPP9_9PSED/429-473 AC A0A239HPP9.1
A0A2S0PAL3_9NEIS/426-470 ..v--SFTQDFVVSARSNRSVLQTATGiD.....PG......AVDALFDAQGNPATLSTG...
A0A089YQU6_9PSED/422-466 ...GNDFTLDMTVARTSNRAVISDMCA.D.....PE......QVDDCFLAAGQQKRLPEG...
A0A2S0PD28_9NEIS/419-464 gnq--PYTLAMVVSSTSNRTLQQSDGL.T.....PA......DVDAGFDAAGQLLALAAG...
A0A2S0P8T4_9NEIS/420-464 .as--AYTLAMIVAQTSNRAVRQTGDL.T.....PA......DIDGLFDACGNLLQLQPG...
A0A077PQ26_XENBV/422-466 ...GNNHVTSLTVSSRNNRAVLSTFTH.D.....PD......KVDHWFDAGGHQTALLPG...
M1SR07_MORMO/421-465 ...NNNYTTDITVSQRSNRAVLKTLAD.T.....PE......KAEALFTPGGQQTQLQPG...
A0A2U8I357_9GAMM/416-460 ..a-NRYTTHINVSQQSNHALFQDGDE.R....qSH......QIESLFDAAGNQQQLQ--y..
M1SJJ1_MORMO/70-114 ...GNNHTTDITVSQRSNRAVLKTLAD.T.....PE......KAEALFTPGGQQTQLQPG...
A0A1D8TQN2_9CYAN/1862-1902 ..r----TRNLTVSETSNRAVDSELLE.G.....NR......DIDQFFDANGNQIQM---sg.
H2ISD9_RAHAC/432-476 ...NNNYTTSITISDRTNRGVLSTLTG.E.....SS......EVDALFTARGVQKQLQPG...
Q7N7Y4_PHOLL/424-468 ...QNNYTTNITVSHQSNRAVLSTLTE.D.....PT......QVDALFDAGGHQNTLIAG...
A0A077PFE7_XENBV/425-467 ...GNNYT--ITVSERNNHAVLSTLTD.I.....PS......TVDTFFDKAGSQLQLMPG...
W1J1L4_9GAMM/432-476 ...GNNYTTTVTVSNRSNRAVLSTLTE.N.....PA......DVDMLFNANGSQRQLQPG...
Q7N7Y7_PHOLL/417-461 ...QNNYTTNITVSNYSNRAVLSTLTE.D.....PT......QVDALFDSGGHQTNLLSG...
Q7N7X5_PHOLL/420-464 ...QNNYTTDITVSNRSNHAVLNSLTT.D.....PT......QVDTLFDAGGHQKKLLPG...
A0A089Q1C3_9ENTR/428-472 ...NNRYTTDITISDRSNRGVLSTLAK.S.....PS......DVDGLFTPGGQQKQLQPG...
D3VHI0_XENNA/422-466 ...GNNYTTNMTVSDHSNRAVLEELAQ.D.....PT......QVDMLFTPGGHQTRLVPG...
A0A2Z6EYD0_9BURK/428-472 ...NNNYTTDITVSNRSNRAVLSQPGL.M.....PD......GVDALFDAGGHQKSLLPG...
Q0WEK9_YERPE/432-476 ...NNSYTTKITVSDRSNRGVLSTLTE.N.....AA......DVDALFTAGGQQTKLQPG...
A0A380SCC3_YERPE/429-473 ...GSGHTTDITVSDRSNQGVLSTLTT.N.....PA......EVDALFTAGGQQKQLQPG...
A0A4P7KQ39_9GAMM/432-468 ...NNNYTINITISDRSNRGVLSTLTE.D.....PT......EVDALFTAA---------v..
A0A2Z6EY71_9BURK/428-472 ...NNNYTTDITVSDRSNRAVLSQPGL.T.....PG......GVDALFDAGGNQKSLLPG...
A0A2A2HMI0_9GAMM/48-92 ...NNNYTVNITVSDRTNRAVLSSLTE.D.....PT......MVDRLFTSGGQQQQLLSG...
W1J412_9GAMM/431-475 ...GNSYTTQITVSDRSNRAVLNLLAE.D.....TT......KVDALFDAGGHQSQLLPG...
W1J3J6_9GAMM/422-466 ...GNNYTTNMTVSDYSNRAVLEALAE.D.....PA......KVDMLFTPGGHQTRLVPG...
D3VFD3_XENNA/420-464 ...QNNHTINITVSNRTNRGVLSSLTD.D.....PN......KVDALFNAGGQQINLLPG...
Q7N7Z1_PHOLL/412-456 ...QNNYTTAITISNRSNRGVLSTLTT.D.....PN......QVDTLFDAGGHQTSLLPG...
Q0WAX8_YERPE/479-523 .as--QYSTHITVSDSSNHGIQQQEGI.T.....AR......DIRSQFDAAGNQQQLQPG...
A0A3B0J4V9_9GAMM/172-216 ...NNSYTTNITVSNRSNRAVLSNLTT.D.....PL......QVDELIDAGGHQSELQP-a..
A0A2X4TMW6_SALER/422-466 ...GNCHTTYITVSDSSNRAVLRSLAA.T.....PA......EVEMHFGPSGEQLQLQPG...
A0A3D9UFP2_9GAMM/426-470 ..r-NNHATSLTVSSRNNRAVLSAFTT.D.....PE......QVDTWFDAGGHQTSLLPG...
H2J1R8_RAHAC/432-476 ...NNNYTQAITVSDRSNRGVSGTLAE.I.....PS......QVDASFTAGGQQKYLQPG...
A0A014NAG0_9GAMM/431-475 ...GNNYTTKITVSDRSNRAVLSSLVA.R.....AE......EVDALFTNRGCQTELVSG...
A0A077PIY4_XENBV/414-458 ...NNNYTLNITVSNRSNHAVSQDLAE.K.....PE......QVDTQFDAGGHQMNLIQG...
A9MLT1_SALAR/422-466 ...GNCHTTYITVSDSSNRAVLRSLAA.T.....PA......EVEMHFGPSGEQLQLQPG...
Q7MZV7_PHOLL/425-469 ...QNSYTTEMTVSSRSNRTVLSTLTT.D.....PT......QVDGLFDAGGHQKTLIPG...
Q7MZ20_PHOLL/416-460 ...NNNYTTNITISNRNNRGVLSTLTN.D.....PN......LVDTFFDAGGHQTSLFSG...
A0A2V2YWD9_9BACL/1659-1699 .tr----TLSLTVSSCSNRAVPSSQTM.D.....AA......QVDALFDASGCLK-----qde
A0A947DCR3_9CYAN/1823-1873 .hg--NHTQRLTVSDRSNRAVESDLLT.At...qPQpmaaavEIDRFFDANGNQTR----tk.
A0A089YU68_9PSED/417-461 ...GAGFITELTTSTRSNRTLPSSLCD.D.....PS......QIDDHFDAAGQQRALDHS...
A0A2Z6EY43_9BURK/426-470 ...GNNYTTEITVSDRSNRAVLSQPGL.T.....PG......EVDVLFDAGGHQKSLQPG...
Q7MZU2_PHOLL/419-463 ...QNNYTTDITVSNRSNRAVLSTLTT.D.....PT......KVDALFQAGGHQETLLPG...
W1IQG7_9GAMM/426-470 ..r-NNHATSLTVSSRNNRAVLSAFTT.D.....PE......QVDTWFDAGGHQTSLLPG...
A0A077PIS5_XENBV/423-467 ...GNSYTTDITVSDHSNRAVLSTLTE.N.....SA......EVDVLFTAGGQQIQLQP-r..
D3VGF9_XENNA/433-482 ...GNNWTTDIAISTTANRGVSTALFT.DitpqnPE......QVDTLFDRAGNQLQLQPG...
A0A239EU47_9PSED/408-452 .nh--SFTRDMTVSQYSNRAVIAALTD.D.....PE......HVDALFSPQGQQRYLQPG...
A0A239HPP9_9PSED/429-473 ..a-SSHTVDITVSDRSCRAVLSSLAA.T.....PE......EVDALFSGAGGQRSLQPG...
#=GC seq_cons ...tNsYTTsITVSsRSNRAVLSoLsp.s.....Ps......pVDsLFsAuGpQppL.PG...
//
