GenomeNet

Database: Pfam
Entry: Tcell_CD4_C
LinkDB: Tcell_CD4_C
Original site: Tcell_CD4_C 
#=GF ID   Tcell_CD4_C
#=GF AC   PF12104.8
#=GF DE   T cell CD4 receptor C terminal region
#=GF PI   Tcell_CD4_Cterm;
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Gavin OL;
#=GF SE   pdb_1q68
#=GF GA   20.60 20.60;
#=GF TC   21.30 20.60;
#=GF NC   18.20 17.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   14500983
#=GF RT   A zinc clasp structure tethers Lck to T cell coreceptors CD4 and
#=GF RT   CD8.
#=GF RA   Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ;
#=GF RL   Science. 2003;301:1725-1728.
#=GF DR   INTERPRO; IPR021963;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is the C terminal domain of the CD4 T cell receptor.
#=GF CC   The C terminal domain is the cytoplasmic domain which relays the
#=GF CC   signal for T cell activation. This process involves co-receptor
#=GF CC   internalisation. This domain is involved in binding to the N
#=GF CC   terminal of Lck co-receptor in a Zn2+ clasp structure.
#=GF SQ   101
#=GS A0A091H214_BUCRH/375-398  AC A0A091H214.1
#=GS CD4_MACMU/426-453         AC P16003.2
#=GS F7I777_CALJA/153-180      AC F7I777.1
#=GS A0A093HUX7_STRCA/376-399  AC A0A093HUX7.1
#=GS A0A091KB69_COLST/375-398  AC A0A091KB69.1
#=GS A0A0D9RD08_CHLSB/528-555  AC A0A0D9RD08.1
#=GS F7AB77_MONDO/344-369      AC F7AB77.2
#=GS A0A093CSY3_TAUER/375-398  AC A0A093CSY3.1
#=GS L8Y3X9_TUPCH/436-459      AC L8Y3X9.1
#=GS A0A091LFM8_CATAU/376-399  AC A0A091LFM8.1
#=GS CD4_MOUSE/425-452         AC P06332.1
#=GS W5P8J4_SHEEP/513-527      AC W5P8J4.1
#=GS A0A091PV80_LEPDC/375-398  AC A0A091PV80.1
#=GS F6WG07_ORNAN/478-499      AC F6WG07.2
#=GS U3I4I6_ANAPL/455-482      AC U3I4I6.1
#=GS A0A091UPT0_NIPNI/375-398  AC A0A091UPT0.1
#=GS V8PDS0_OPHHA/367-392      AC V8PDS0.1
#=GS A0A091EII6_CORBR/372-397  AC A0A091EII6.1
#=GS G7PJN3_MACFA/426-453      AC G7PJN3.1
#=GS S7N841_MYOBR/431-454      AC S7N841.1
#=GS G3QL31_GORGO/426-453      AC G3QL31.1
#=GS F1SLT5_PIG/425-452        AC F1SLT5.1
#=GS A0A1A6HFA7_NEOLE/369-392  AC A0A1A6HFA7.1
#=GS H9GAP5_ANOCA/1-24         AC H9GAP5.1
#=GS A0A091SDT1_9GRUI/375-398  AC A0A091SDT1.1
#=GS A0A099ZZE9_CHAVO/375-398  AC A0A099ZZE9.1
#=GS A0A091GEQ9_9AVES/374-397  AC A0A091GEQ9.1
#=GS A0A2I0MLQ8_COLLI/448-475  AC A0A2I0MLQ8.1
#=GS A0A1S3WTS2_ERIEU/422-449  AC A0A1S3WTS2.1
#=GS H0VL66_CAVPO/440-464      AC H0VL66.2
#=GS CD4_PANTR/426-453         AC P16004.1
#=GS A0A093IJ13_DRYPU/375-398  AC A0A093IJ13.1
#=GS G1QAX4_MYOLU/426-447      AC G1QAX4.1
#=GS A0A091S3U4_NESNO/375-398  AC A0A091S3U4.1
#=GS A0A093C2M2_9AVES/375-398  AC A0A093C2M2.1
#=GS A0A1V4JB63_PATFA/454-481  AC A0A1V4JB63.1
#=GS G1M645_AILME/381-408      AC G1M645.1
#=GS A0A093FFP9_GAVST/374-397  AC A0A093FFP9.1
#=GS A0A2I2UV30_FELCA/448-475  AC A0A2I2UV30.1
#=GS I6LI22_MUSPF/430-457      AC I6LI22.1
#=GS H0XBR4_OTOGA/343-370      AC H0XBR4.1
#=GS G3UBY8_LOXAF/417-444      AC G3UBY8.1
#=GS A0A087RHA1_APTFO/375-398  AC A0A087RHA1.1
#=GS A0A093INP9_FULGA/375-398  AC A0A093INP9.1
#=GS G3U7C0_LOXAF/417-445      AC G3U7C0.1
#=GS A0A093N9B7_PYGAD/375-398  AC A0A093N9B7.1
#=GS G3UCG3_LOXAF/417-450      AC G3UCG3.1
#=GS CD4_CANLF/431-458         AC P33705.1
#=GS A0A091VVS5_OPIHO/375-398  AC A0A091VVS5.1
#=GS A0A093JFH7_EURHL/373-396  AC A0A093JFH7.1
#=GS G3WTA4_SARHA/460-485      AC G3WTA4.1
#=GS H2NG98_PONAB/382-409      AC H2NG98.1
#=GS A0A091SDM9_9AVES/372-395  AC A0A091SDM9.1
#=GS A0A093F2M0_TYTAL/375-398  AC A0A093F2M0.1
#=GS A0A093RTI8_9PASS/366-389  AC A0A093RTI8.1
#=GS A0A091MUG6_CARIC/375-398  AC A0A091MUG6.1
#=GS A0A091J8V4_EGRGA/374-397  AC A0A091J8V4.1
#=GS I3NES8_ICTTR/419-446      AC I3NES8.1
#=GS M7B2Z9_CHEMY/377-400      AC M7B2Z9.1
#=GS G5CAQ9_HETGA/407-433      AC G5CAQ9.1
#=GS K7G8F0_PELSI/431-457      AC K7G8F0.1
#=GS A0A091L1Z6_9GRUI/374-397  AC A0A091L1Z6.1
#=GS A0A2K5K7H1_COLAP/426-453  AC A0A2K5K7H1.1
#=GS W5P8J5_SHEEP/432-450      AC W5P8J5.1
#=GS A0A151MCU8_ALLMI/518-546  AC A0A151MCU8.1
#=GS A0A096MWA4_PAPAN/426-453  AC A0A096MWA4.1
#=GS L5KFG2_PTEAL/348-375      AC L5KFG2.1
#=GS G1QXL1_NOMLE/426-453      AC G1QXL1.1
#=GS F1SLT4_PIG/401-428        AC F1SLT4.2
#=GS A0A091UGP9_PHORB/375-398  AC A0A091UGP9.1
#=GS G3ULS8_LOXAF/434-467      AC G3ULS8.1
#=GS A0A093S7H6_PHACA/372-395  AC A0A093S7H6.1
#=GS G3TZC2_LOXAF/429-456      AC G3TZC2.1
#=GS A0A091CQ95_FUKDA/850-873  AC A0A091CQ95.1
#=GS F6Y6X8_HORSE/429-456      AC F6Y6X8.1
#=GS CD4_RAT/425-452           AC P05540.1
#=GS G1NMU4_MELGA/461-488      AC G1NMU4.2
#=GS A0A151MBR4_ALLMI/74-95    AC A0A151MBR4.1
#=GS G3GUN9_CRIGR/424-447      AC G3GUN9.1
#=GS F1NGI9_CHICK/460-487      AC F1NGI9.1
#=GS F1MJK4_BOVIN/423-449      AC F1MJK4.2
#=GS F7ILX9_CALJA/358-385      AC F7ILX9.1
#=GS M3W1W4_FELCA/442-469      AC M3W1W4.2
#=GS A0A1D5PK32_CHICK/460-486  AC A0A1D5PK32.1
#=GS A0A091PM83_HALAL/372-395  AC A0A091PM83.1
#=GS A0A0G3FB31_CERAT/426-453  AC A0A0G3FB31.1
#=GS G3TWZ4_LOXAF/426-452      AC G3TWZ4.1
#=GS A0A091RAA2_MERNU/375-398  AC A0A091RAA2.1
#=GS L5M931_MYODS/428-455      AC L5M931.1
#=GS A0A1U8DZG6_ALLSI/458-486  AC A0A1U8DZG6.1
#=GS A0A1U7Q3K5_MESAU/367-394  AC A0A1U7Q3K5.1
#=GS CD4_HUMAN/426-453         AC P01730.1
#=GS CD4_HUMAN/426-453         DR PDB; 3B71 E; 406-416;
#=GS CD4_HUMAN/426-453         DR PDB; 2JKT Q; 2-10;
#=GS CD4_HUMAN/426-453         DR PDB; 1WBR A; 403-419;
#=GS CD4_HUMAN/426-453         DR PDB; 2JKR Q; 2-10;
#=GS CD4_HUMAN/426-453         DR PDB; 3B71 D; 406-416;
#=GS CD4_HUMAN/426-453         DR PDB; 2JKR P; 2-10;
#=GS CD4_HUMAN/426-453         DR PDB; 2KLU A; 401-428;
#=GS CD4_HUMAN/426-453         DR PDB; 3B71 F; 408-416;
#=GS CD4_HUMAN/426-453         DR PDB; 1Q68 A; 401-428;
#=GS CD4_HUMAN/426-453         DR PDB; 2JKT P; 2-10;
#=GS I3L556_PIG/462-489        AC I3L556.2
#=GS A0A091I8Q3_CALAN/373-396  AC A0A091I8Q3.1
#=GS G1T4B9_RABIT/427-454      AC G1T4B9.1
#=GS U3JQ50_FICAL/460-487      AC U3JQ50.1
#=GS A0A091MIH9_9PASS/370-393  AC A0A091MIH9.1
#=GS H0ZSV2_TAEGU/374-403      AC H0ZSV2.1
#=GS CD4_RABIT/427-454         AC P46630.1
#=GS F6XGD3_MACMU/426-450      AC F6XGD3.2
#=GS A0A099Z1Z0_TINGU/377-400  AC A0A099Z1Z0.1
A0A091H214_BUCRH/375-398             ...........RQQAKKMARARRYLLENKTCQCQ.-..----q...
CD4_MACMU/426-453                    ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK....
F7I777_CALJA/153-180                 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK....
A0A093HUX7_STRCA/376-399             ...........RQRAKRMALARQHLLENRTCQCQ.-..----q...
A0A091KB69_COLST/375-398             ...........RQRAKRMARARQHLLENKTCQCQ.-..----q...
A0A0D9RD08_CHLSB/528-555             ...........RRQAQRMSQIKRLLSEKKTCQCP.H..RFQK....
F7AB77_MONDO/344-369                 ..........l-RRAERMSQIRRLLSEKKTCQCP.H..RF--....
A0A093CSY3_TAUER/375-398             ...........RQRAKKMARARQYLLENKTCQCQ.-..----q...
L8Y3X9_TUPCH/436-459                 ...........RRQAERMSQIKRLLKEKKPCQCS.-..----q...
A0A091LFM8_CATAU/376-399             ...........RQRAKRMARARQHLLENKTCQCQ.-..----q...
CD4_MOUSE/425-452                    ..........q-RQAARMSQIKRLLSEKKTCQCP.H..RMQK....
W5P8J4_SHEEP/513-527                 ..........p----------KRLLSEKKTCQCP.-..----q...
A0A091PV80_LEPDC/375-398             ...........RQRAKKMARARQYLLENKTCQCQ.-..----q...
F6WG07_ORNAN/478-499                 ..........q-QRAERVSQIRRLLKDNKTCQC-.-..----....
U3I4I6_ANAPL/455-482                 ...........RQRAKRMARARQYLLEKKTCQCQ.H..RMNK....
A0A091UPT0_NIPNI/375-398             ...........RQRAKRMARARQYLLENKTCQCQ.-..----q...
V8PDS0_OPHHA/367-392                 ..........q-QQAKRMAQIKQHLLAKRTCQCQ.R..----dl..
A0A091EII6_CORBR/372-397             ........rrm-QRRKRMAQARQYLLENKTCQCQ.-..----q...
G7PJN3_MACFA/426-453                 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK....
S7N841_MYOBR/431-454                 ...........RRQAVRMSQIKRLLSEKKTCQCP.-..----q...
G3QL31_GORGO/426-453                 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK....
F1SLT5_PIG/425-452                   ...........RRRAERMSQIKRLLSEKKTCQCA.H..RQQK....
A0A1A6HFA7_NEOLE/369-392             ..........q-RQAERMSQIKRLLSEKKTCQCS.-..----q...
H9GAP5_ANOCA/1-24                    ..........q-QRARRMAQAKQHLLEKKTCQCE.R..----....
A0A091SDT1_9GRUI/375-398             ...........RQQAKRMIRARQHLLENKTCQCQ.-..----q...
A0A099ZZE9_CHAVO/375-398             ...........RQRAKRMVRARQYLLENKTCQCQ.-..----q...
A0A091GEQ9_9AVES/374-397             ...........RQRARRMARARQYLLENKTCQCR.-..----q...
A0A2I0MLQ8_COLLI/448-475             ...........RQRAKRMVQARQYLLENKTCQCQ.H..RLNK....
A0A1S3WTS2_ERIEU/422-449             ...........RRQAERMSQIKRLLREKKTCQCS.H..RLQK....
H0VL66_CAVPO/440-464                 ...........RRQAARMSQIKRLLSEKKTCQCH.R..----p...
CD4_PANTR/426-453                    ...........RRQAQRMSQIKRLLSEKKTCQCP.H..RFQK....
A0A093IJ13_DRYPU/375-398             ...........RQRARKMAQARQYLLENKTCQCH.-..----q...
G1QAX4_MYOLU/426-447                 ...........RRQAVRMSQIKRLLSEKKTCQC-.-..----....
A0A091S3U4_NESNO/375-398             ...........RQRRKRMAQARQYLLENKTCQCQ.R..----....
A0A093C2M2_9AVES/375-398             ...........RQRAKRMARARQYLLENKTCQCQ.-..----q...
A0A1V4JB63_PATFA/454-481             ...........RQRAKRMVQARQYLLENKTCQCQ.H..RLNK....
G1M645_AILME/381-408                 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK....
A0A093FFP9_GAVST/374-397             ...........RQRAKRMARARQYLLENKTCQCQ.-..----q...
A0A2I2UV30_FELCA/448-475             ...........RRQAARMSHIKRLLSEKKTCQCS.H..RLQK....
I6LI22_MUSPF/430-457                 ...........RRQAARMSQIKRLLSEKKTCQCP.H..RLQK....
H0XBR4_OTOGA/343-370                 ...........RRQTERKSQIKRLLSEKKTCQCV.H..RFQK....
G3UBY8_LOXAF/417-444                 ..rrrvseppq------MSQIKRLLSEKKTCQCP.-..----sk..
A0A087RHA1_APTFO/375-398             ...........RQRAKRMARARQYLLENKTCQCQ.-..----q...
A0A093INP9_FULGA/375-398             ...........RQRAKRMAQARQYLLENKTCQCQ.-..----q...
G3U7C0_LOXAF/417-445                 ...........RHQRRRMSQIKRLLSEKKTCQCPsN..RLQK....
A0A093N9B7_PYGAD/375-398             ...........RQRAKRMARARQYLLENKTCQCQ.-..----q...
G3UCG3_LOXAF/417-450                 rhqrrrvsepp------MSQIKRLLSEKKTCQCPsN..RLQK....
CD4_CANLF/431-458                    ...........RRQAERMSQIKRLLSEKKTCQCS.H..RIQK....
A0A091VVS5_OPIHO/375-398             ...........RQRAKTMARARQYLLENKTCQCQ.-..----q...
A0A093JFH7_EURHL/373-396             ...........RQRAKRMARARQYLLENKTCQCQ.-..----q...
G3WTA4_SARHA/460-485                 ..........l-RRAERMSQIRRLLSEKKTCQCP.H..HF--....
H2NG98_PONAB/382-409                 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK....
A0A091SDM9_9AVES/372-395             ...........RQRVKRMARARQLLLEKKTCQCQ.-..----q...
A0A093F2M0_TYTAL/375-398             ...........RQQAKRMARARRYLMENKTCQCQ.-..----q...
A0A093RTI8_9PASS/366-389             ...........RQRAKRMAQARQYLLENKTCQCQ.-..----q...
A0A091MUG6_CARIC/375-398             ...........RQRAKRMARARQYLLENKTCQCQ.-..----q...
A0A091J8V4_EGRGA/374-397             ...........RQRARRMARARQYLLENKTCQCQ.-..----q...
I3NES8_ICTTR/419-446                 ...........RRQAERMSQIKRLLSEKKTCQCS.H..RLQK....
M7B2Z9_CHEMY/377-400                 ...........RQRAEKMAQARRDLFERRTCQCQ.R..----....
G5CAQ9_HETGA/407-433                 ......crhrq-RRAARMSQIKRLLSEKKTCQCP.-..----....
K7G8F0_PELSI/431-457                 ...........RRRAERMVRARRDLIERRTCQCQ.-..----ffmv
A0A091L1Z6_9GRUI/374-397             ...........RQRAKRMVRARQYLLENKTCQCQ.-..----q...
A0A2K5K7H1_COLAP/426-453             ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK....
W5P8J5_SHEEP/432-450                 ..........p----------KRLLSEKKTCQCP.H..RLQK....
A0A151MCU8_ALLMI/518-546             .........rk-RRAKRMVRVRRDLLENRMCQCQ.H..RL--rn..
A0A096MWA4_PAPAN/426-453             ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK....
L5KFG2_PTEAL/348-375                 ......crhrk-RQAERMSQIKRLLSEKKTCQCP.-..----q...
G1QXL1_NOMLE/426-453                 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK....
F1SLT4_PIG/401-428                   ..........q-RRAERMSQIKRLLSEKKTCQCA.H..RQQK....
A0A091UGP9_PHORB/375-398             ...........RQRAKRMAQARQYLLENKTCQCQ.-..----q...
G3ULS8_LOXAF/434-467                 rhqrrrvsepp------MSQIKRLLSEKKTCQCPsN..RLQK....
A0A093S7H6_PHACA/372-395             ...........RQRAKRMAQARQYLLENKTCQCQ.-..----q...
G3TZC2_LOXAF/429-456                 ..rrrvseppq------MSQIKRLLSEKKTCQCP.-..----sk..
A0A091CQ95_FUKDA/850-873             ..........q-RRAEQMSQIKRLLSEKKTCQCS.-..----q...
F6Y6X8_HORSE/429-456                 ...........RRQAERMSQIKRLLSEKKTCQCH.H..RFQK....
CD4_RAT/425-452                      ..........q-RQAARMSQIKRLLSEKKTCQCS.H..RMQK....
G1NMU4_MELGA/461-488                 ...........RKRAKRIAQAKQYLLEKKTCQCQ.R..RMYK....
A0A151MBR4_ALLMI/74-95               .........ss--------YAKNTIQEKQTCQCS.H..RSV-k...
G3GUN9_CRIGR/424-447                 ...........RRQAERMSQIKRLLSEKKTCQCS.-..----q...
F1NGI9_CHICK/460-487                 ...........RKRARRMAQAKQYLLEKKTCQCQ.R..RMYK....
F1MJK4_BOVIN/423-449                 ...........RRRAERMSQIKRLLSEKKTCQCP.H..----eaq.
F7ILX9_CALJA/358-385                 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK....
M3W1W4_FELCA/442-469                 ...........RRQAARMSHIKRLLSEKKTCQCS.H..RLQK....
A0A1D5PK32_CHICK/460-486             ...........RKRARRMAQAKQYLLEKKTCQCQ.R..----lqq.
A0A091PM83_HALAL/372-395             ...........RQRAKRMARARQYLLENKTCQCQ.-..----q...
A0A0G3FB31_CERAT/426-453             ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK....
G3TWZ4_LOXAF/426-452                 .......ppqx------MSQIKRLLSEKKTCQCPsN..RLQK....
A0A091RAA2_MERNU/375-398             ...........RQRAKRMAQARQYLLENKTCQCR.-..----q...
L5M931_MYODS/428-455                 ...........RRQAVRMSQIKRLLSEKKTCQCP.H..RFQK....
A0A1U8DZG6_ALLSI/458-486             .........rk-RRAKRMVRVRRDLLENRTCQCQ.H..RL--rn..
A0A1U7Q3K5_MESAU/367-394             ...........RRQAERMSQIKRLLSEKKTCQCS.H..RMQK....
CD4_HUMAN/426-453                    ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK....
#=GR CD4_HUMAN/426-453         SS    ...........SSSXTTHHCHHHHHHSSSSXXXX.X..SXXX....
I3L556_PIG/462-489                   ...........RRRAERMSQIKRLLSEKKTCQCA.H..RQQK....
A0A091I8Q3_CALAN/373-396             ...........RQRAKRMAQARQYLRENKRCQCQ.-..----q...
G1T4B9_RABIT/427-454                 ...........RHQAQRMSQIKKLLSEKKTCQCP.H..RLQK....
U3JQ50_FICAL/460-487                 ...........RQRAKRMAQARQYLLENKTCQCQ.H..RLKK....
A0A091MIH9_9PASS/370-393             ...........RQRAKRMALAREYLLENKTCQCQ.-..----q...
H0ZSV2_TAEGU/374-403                 ...........RQRAKRMAQARQYLLENKTCQCQ.QapRMGK....
CD4_RABIT/427-454                    ...........RHQAQRMSQIKKLLSEKKTCQCP.H..RLQK....
F6XGD3_MACMU/426-450                 ...........RRQAERMSQIKRLLSEKKTCQCP.H..----l...
A0A099Z1Z0_TINGU/377-400             ...........RQRAKRMALARQHLLENRTCQCK.-..----q...
#=GC SS_cons                         ...........SSSXTTHHCHHHHHHSSSSXXXX.X..SXXX....
#=GC seq_cons                        ...........RppAcRMuQh+phL.E+KTCQCp............
//
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