GenomeNet

Database: Pfam
Entry: Tcell_CD4_C
LinkDB: Tcell_CD4_C
Original site: Tcell_CD4_C 
#=GF ID   Tcell_CD4_C
#=GF AC   PF12104.10
#=GF DE   T cell CD4 receptor C terminal region
#=GF PI   Tcell_CD4_Cterm;
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Gavin OL;
#=GF SE   pdb_1q68
#=GF GA   20.60 20.60;
#=GF TC   20.60 20.60;
#=GF NC   20.50 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   14500983
#=GF RT   A zinc clasp structure tethers Lck to T cell coreceptors CD4 and
#=GF RT   CD8.
#=GF RA   Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ;
#=GF RL   Science. 2003;301:1725-1728.
#=GF DR   INTERPRO; IPR021963;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is the C terminal domain of the CD4 T cell receptor.
#=GF CC   The C terminal domain is the cytoplasmic domain which relays the
#=GF CC   signal for T cell activation. This process involves co-receptor
#=GF CC   internalisation. This domain is involved in binding to the N
#=GF CC   terminal of Lck co-receptor in a Zn2+ clasp structure.
#=GF SQ   135
#=GS A0A091H214_BUCRH/375-398  AC A0A091H214.1
#=GS A0A1U7Q3K5_MESAU/424-451  AC A0A1U7Q3K5.2
#=GS A0A093HUX7_STRCA/376-399  AC A0A093HUX7.1
#=GS A0A2K6U8E4_SAIBB/424-452  AC A0A2K6U8E4.1
#=GS A0A493TGC3_ANAPP/232-255  AC A0A493TGC3.1
#=GS A0A2Y9NP79_DELLE/423-450  AC A0A2Y9NP79.1
#=GS CD4_CANLF/429-458         AC P33705.1
#=GS M3W1W4_FELCA/454-482      AC M3W1W4.3
#=GS A0A091PV80_LEPDC/375-398  AC A0A091PV80.1
#=GS A0A096MWA4_PAPAN/425-453  AC A0A096MWA4.1
#=GS A0A3Q7W019_URSAR/429-457  AC A0A3Q7W019.1
#=GS A0A091EII6_CORBR/372-397  AC A0A091EII6.1
#=GS F1MJK4_BOVIN/423-446      AC F1MJK4.3
#=GS CD4_DELLE/423-450         AC Q9XS78.1
#=GS G3WTA4_SARHA/459-484      AC G3WTA4.1
#=GS A0A1A6HFA7_NEOLE/369-392  AC A0A1A6HFA7.1
#=GS A0A673U8S3_SURSU/438-466  AC A0A673U8S3.1
#=GS H9GAP5_ANOCA/1-24         AC H9GAP5.1
#=GS A0A091SDT1_9GRUI/375-398  AC A0A091SDT1.1
#=GS A0A3Q7RWR8_VULVU/428-457  AC A0A3Q7RWR8.1
#=GS A0A091GEQ9_9AVES/374-397  AC A0A091GEQ9.1
#=GS A0A670JWW5_PODMU/343-369  AC A0A670JWW5.1
#=GS A0A093IJ13_DRYPU/375-398  AC A0A093IJ13.1
#=GS Q71QE2_TURTR/423-450      AC Q71QE2.1
#=GS A0A672U131_STRHB/418-443  AC A0A672U131.1
#=GS A0A2U3WWZ7_ODORO/429-457  AC A0A2U3WWZ7.1
#=GS A0A093C2M2_9AVES/375-398  AC A0A093C2M2.1
#=GS A0A671DTY9_RHIFE/430-458  AC A0A671DTY9.1
#=GS A0A093FFP9_GAVST/374-397  AC A0A093FFP9.1
#=GS A0A0G3FB31_CERAT/425-453  AC A0A0G3FB31.1
#=GS A0A402FAI3_9SAUR/229-256  AC A0A402FAI3.1
#=GS I3NES8_ICTTR/418-446      AC I3NES8.1
#=GS F6Y6X8_HORSE/427-455      AC F6Y6X8.3
#=GS G3U7C0_LOXAF/417-445      AC G3U7C0.1
#=GS A0A093INP9_FULGA/375-398  AC A0A093INP9.1
#=GS A0A2Y9H3X9_NEOSC/429-457  AC A0A2Y9H3X9.1
#=GS A0A093N9B7_PYGAD/375-398  AC A0A093N9B7.1
#=GS A0A2K5YPB8_MANLE/425-453  AC A0A2K5YPB8.1
#=GS CD4_MACMU/425-453         AC P16003.2
#=GS A0A5F4D9E1_CANLF/428-457  AC A0A5F4D9E1.1
#=GS A0A093JFH7_EURHL/373-396  AC A0A093JFH7.1
#=GS A0A091SDM9_PELCR/372-395  AC A0A091SDM9.1
#=GS A0A2K5YP95_MANLE/152-182  AC A0A2K5YP95.1
#=GS A0A093F2M0_TYTAL/375-398  AC A0A093F2M0.1
#=GS CD4_PANTR/425-453         AC P16004.1
#=GS A0A5E4B7B3_MARMO/393-421  AC A0A5E4B7B3.1
#=GS M7B2Z9_CHEMY/377-400      AC M7B2Z9.1
#=GS A0A091J8V4_EGRGA/374-397  AC A0A091J8V4.1
#=GS A0A2R9B4G7_PANPA/425-453  AC A0A2R9B4G7.1
#=GS A6MAP0_MONDO/435-461      AC A6MAP0.1
#=GS A0A2K6DWJ0_MACNE/425-453  AC A0A2K6DWJ0.1
#=GS A0A212CD61_CEREH/375-398  AC A0A212CD61.1
#=GS A0A663F402_AQUCH/441-464  AC A0A663F402.1
#=GS A0A1D5PK32_CHICK/412-439  AC A0A1D5PK32.2
#=GS F6XGD3_MACMU/422-453      AC F6XGD3.3
#=GS A0A093S7H6_PHACA/372-395  AC A0A093S7H6.1
#=GS A0A383Z543_BALAS/422-450  AC A0A383Z543.1
#=GS A0A672U0G2_STRHB/415-440  AC A0A672U0G2.1
#=GS A0A2U3Y2Q1_LEPWE/429-457  AC A0A2U3Y2Q1.1
#=GS A0A341AHR6_NEOAA/423-450  AC A0A341AHR6.1
#=GS A0A2K5K7H1_COLAP/425-453  AC A0A2K5K7H1.1
#=GS L8HVB0_9CETA/423-446      AC L8HVB0.1
#=GS CD4_MACFA/425-453         AC P79185.1
#=GS U3JQ50_FICAL/460-487      AC U3JQ50.1
#=GS CD4_RABIT/427-454         AC P46630.1
#=GS A0A099Z1Z0_TINGU/377-400  AC A0A099Z1Z0.1
#=GS G3QL31_GORGO/425-453      AC G3QL31.1
#=GS A0A452IQE6_9SAUR/449-475  AC A0A452IQE6.1
#=GS G1QXL1_NOMLE/425-453      AC G1QXL1.1
#=GS A0A091KB69_COLST/375-398  AC A0A091KB69.1
#=GS A0A093CSY3_TAUER/375-398  AC A0A093CSY3.1
#=GS A0A2Y9E6V4_TRIMA/434-461  AC A0A2Y9E6V4.1
#=GS A0A2Y9KWP3_ENHLU/430-458  AC A0A2Y9KWP3.1
#=GS H0ZSV2_TAEGU/369-396      AC H0ZSV2.2
#=GS A0A452E3R1_CAPHI/422-450  AC A0A452E3R1.1
#=GS A0A091LFM8_CATAU/376-399  AC A0A091LFM8.1
#=GS CD4_MOUSE/425-452         AC P06332.1
#=GS A0A2K6NUB6_RHIRO/425-453  AC A0A2K6NUB6.1
#=GS A0A091UPT0_NIPNI/375-398  AC A0A091UPT0.1
#=GS F7ILX9_CALJA/424-452      AC F7ILX9.2
#=GS A0A2K5E3A9_AOTNA/424-452  AC A0A2K5E3A9.1
#=GS V8PDS0_OPHHA/367-392      AC V8PDS0.1
#=GS G1QAX4_MYOLU/425-447      AC G1QAX4.1
#=GS A0A672TZQ4_STRHB/443-467  AC A0A672TZQ4.1
#=GS A0A2Y9RYS9_TRIMA/434-458  AC A0A2Y9RYS9.1
#=GS S7N841_MYOBR/430-454      AC S7N841.1
#=GS A0A099ZZE9_CHAVO/375-398  AC A0A099ZZE9.1
#=GS L5M931_MYODS/427-455      AC L5M931.1
#=GS A0A2I0MLQ8_COLLI/448-475  AC A0A2I0MLQ8.1
#=GS A0A1S3WTS2_ERIEU/421-449  AC A0A1S3WTS2.1
#=GS G7PJN3_MACFA/425-453      AC G7PJN3.1
#=GS A0A4W2CPG8_BOBOX/423-450  AC A0A4W2CPG8.1
#=GS A0A663F4F2_AQUCH/432-455  AC A0A663F4F2.1
#=GS A0A2I0U4I8_LIMLA/453-478  AC A0A2I0U4I8.1
#=GS A0A091S3U4_NESNO/375-398  AC A0A091S3U4.1
#=GS A0A1V4JB63_PATFA/454-481  AC A0A1V4JB63.1
#=GS A0A3L8S9T8_CHLGU/460-487  AC A0A3L8S9T8.1
#=GS G5CAQ9_HETGA/410-433      AC G5CAQ9.1
#=GS A0A087RHA1_APTFO/375-398  AC A0A087RHA1.1
#=GS A0A2Y9RUH9_TRIMA/434-459  AC A0A2Y9RUH9.1
#=GS A0A663F3B4_AQUCH/453-476  AC A0A663F3B4.1
#=GS A0A2K5E3B4_AOTNA/371-399  AC A0A2K5E3B4.1
#=GS A0A0D9RD08_CHLSB/527-555  AC A0A0D9RD08.1
#=GS A0A091VVS5_OPIHO/375-398  AC A0A091VVS5.1
#=GS A0A340Y8J8_LIPVE/422-449  AC A0A340Y8J8.1
#=GS G1M645_AILME/380-408      AC G1M645.1
#=GS A0A485MFW6_LYNPA/437-465  AC A0A485MFW6.1
#=GS L5KFG2_PTEAL/351-375      AC L5KFG2.1
#=GS I6LI22_MUSPF/429-457      AC I6LI22.1
#=GS A0A093RTI8_9PASS/366-389  AC A0A093RTI8.1
#=GS A0A091MUG6_CARIC/375-398  AC A0A091MUG6.1
#=GS K7G8F0_PELSI/431-457      AC K7G8F0.1
#=GS A0A091L1Z6_9GRUI/374-397  AC A0A091L1Z6.1
#=GS A0A4X2JRA7_VOMUR/440-466  AC A0A4X2JRA7.1
#=GS CD4_MACNE/425-453         AC Q08340.2
#=GS H0VL66_CAVPO/440-465      AC H0VL66.2
#=GS A0A5E4B698_MARMO/420-448  AC A0A5E4B698.1
#=GS A0A2K6M3L9_RHIBE/425-453  AC A0A2K6M3L9.1
#=GS A0A091UGP9_PHORB/375-398  AC A0A091UGP9.1
#=GS CD4_HUMAN/425-453         AC P01730.1
#=GS CD4_HUMAN/425-453         DR PDB; 3B71 E; 406-416;
#=GS CD4_HUMAN/425-453         DR PDB; 2JKT Q; 2-10;
#=GS CD4_HUMAN/425-453         DR PDB; 1WBR A; 403-419;
#=GS CD4_HUMAN/425-453         DR PDB; 2JKR Q; 2-10;
#=GS CD4_HUMAN/425-453         DR PDB; 3B71 D; 406-416;
#=GS CD4_HUMAN/425-453         DR PDB; 2JKR P; 2-10;
#=GS CD4_HUMAN/425-453         DR PDB; 2KLU A; 400-428;
#=GS CD4_HUMAN/425-453         DR PDB; 6QH6 Q; 2-10;
#=GS CD4_HUMAN/425-453         DR PDB; 6QH7 Q; 2-10;
#=GS CD4_HUMAN/425-453         DR PDB; 3B71 F; 408-416;
#=GS CD4_HUMAN/425-453         DR PDB; 1Q68 A; 400-428;
#=GS CD4_HUMAN/425-453         DR PDB; 2JKT P; 2-10;
#=GS A0A6J3S3P7_TURTR/423-450  AC A0A6J3S3P7.1
#=GS CD4_RAT/425-452           AC P05540.1
#=GS G1NMU4_MELGA/461-488      AC G1NMU4.2
#=GS A0A670JTE6_PODMU/284-310  AC A0A670JTE6.1
#=GS F1NGI9_CHICK/460-487      AC F1NGI9.1
#=GS G3GUN9_CRIGR/424-447      AC G3GUN9.1
#=GS A0A091PM83_HALAL/372-395  AC A0A091PM83.1
#=GS A0A5F8A870_MACMU/246-274  AC A0A5F8A870.1
#=GS A0A091RAA2_MERNU/375-398  AC A0A091RAA2.1
#=GS A0A2K5RGR6_CEBCA/424-452  AC A0A2K5RGR6.1
#=GS I3L556_PIG/462-489        AC I3L556.2
#=GS H2NG98_PONAB/381-409      AC H2NG98.1
#=GS A0A091MIH9_9PASS/370-393  AC A0A091MIH9.1
#=GS G1T4B9_RABIT/427-454      AC G1T4B9.1
#=GS A0A091I8Q3_CALAN/373-396  AC A0A091I8Q3.1
A0A091H214_BUCRH/375-398             ....RQQ.AKKMARARRYLLENKTCQCQ-----q......
A0A1U7Q3K5_MESAU/424-451             ....RRQ.AERMSQIKRLLSEKKTCQCSHRMQK.......
A0A093HUX7_STRCA/376-399             ....RQR.AKRMALARQHLLENRTCQCQ-----q......
A0A2K6U8E4_SAIBB/424-452             ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A493TGC3_ANAPP/232-255             ....RQR.AKRMARARQYLLEKKTCQCQ-----q......
A0A2Y9NP79_DELLE/423-450             ....RRR.AERTSQIKRLLSEKKTCHCSHRLQK.......
CD4_CANLF/429-458                    ..rrRRQ.AERMSQIKRLLSEKKTCQCSHRIQK.......
M3W1W4_FELCA/454-482                 ...rRRQ.AARMSHIKRLLSEKKTCQCSHRLQK.......
A0A091PV80_LEPDC/375-398             ....RQR.AKKMARARQYLLENKTCQCQ-----q......
A0A096MWA4_PAPAN/425-453             ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A3Q7W019_URSAR/429-457             ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A091EII6_CORBR/372-397             .rrm-QR.RKRMAQARQYLLENKTCQCQ-----q......
F1MJK4_BOVIN/423-446                 ....RRR.AERMSQIKRLLSEKKTCQC------pq.....
CD4_DELLE/423-450                    ....RRR.AERTSQIKRLLSEKKTCHCSHRLQK.......
G3WTA4_SARHA/459-484                 ..rl-RR.AERMSQIRRLLSEKKTCQC------phh....
A0A1A6HFA7_NEOLE/369-392             ...q-RQ.AERMSQIKRLLSEKKTCQCS-----q......
A0A673U8S3_SURSU/438-466             ...rRRQ.AERMSQIKRLLSEKKTCQCPHRLQK.......
H9GAP5_ANOCA/1-24                    ...q-QR.ARRMAQAKQHLLEKKTCQCER----.......
A0A091SDT1_9GRUI/375-398             ....RQQ.AKRMIRARQHLLENKTCQCQ-----q......
A0A3Q7RWR8_VULVU/428-457             ..rrRRQ.AERMSQIKRLLSEKKTCQCSHRIQK.......
A0A091GEQ9_9AVES/374-397             ....RQR.ARRMARARQYLLENKTCQCR-----q......
A0A670JWW5_PODMU/343-369             ....RQR.ARRMAQARQHLLEKKTCQCHR----dlt....
A0A093IJ13_DRYPU/375-398             ....RQR.ARKMAQARQYLLENKTCQCH-----q......
Q71QE2_TURTR/423-450                 ....RRR.AQRTSQIKRLLSEKKTCHCSHRLQK.......
A0A672U131_STRHB/418-443             .rrq-QR.RKRMAQARQYLLENKTCQCQR----.......
A0A2U3WWZ7_ODORO/429-457             ...rRRQ.AERMSQIKRLLSENKTCQCSHRLQK.......
A0A093C2M2_9AVES/375-398             ....RQR.AKRMARARQYLLENKTCQCQ-----q......
A0A671DTY9_RHIFE/430-458             ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A093FFP9_GAVST/374-397             ....RQR.AKRMARARQYLLENKTCQCQ-----q......
A0A0G3FB31_CERAT/425-453             ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A402FAI3_9SAUR/229-256             .rkk-RR.SERMTQAKQHLLAKRICQCQR----dk.....
I3NES8_ICTTR/418-446                 ...rRRQ.AERMSQIKRLLSEKKTCQCSHRLQK.......
F6Y6X8_HORSE/427-455                 ...rRRQ.AERMSQIKRLLSEKKTCQCHHRFQK.......
G3U7C0_LOXAF/417-445                 ....RHQ.RRRMSQIKRLLSEKKTCQC------psnrlqk
A0A093INP9_FULGA/375-398             ....RQR.AKRMAQARQYLLENKTCQCQ-----q......
A0A2Y9H3X9_NEOSC/429-457             ...rRRQ.AERMSQIKRLLSEKKTCQCSHRFQK.......
A0A093N9B7_PYGAD/375-398             ....RQR.AKRMARARQYLLENKTCQCQ-----q......
A0A2K5YPB8_MANLE/425-453             ...rRRQ.AQRMSQIKRLLSEKKTCQCPHRFQK.......
CD4_MACMU/425-453                    ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A5F4D9E1_CANLF/428-457             ..rrRRQ.AERMSQIKRLLSEKKTCQCSHRIQK.......
A0A093JFH7_EURHL/373-396             ....RQR.AKRMARARQYLLENKTCQCQ-----q......
A0A091SDM9_PELCR/372-395             ....RQR.VKRMARARQLLLEKKTCQCQ-----q......
A0A2K5YP95_MANLE/152-182             ...rRRQ.AQRMSQIKRLLSEKKTCQCPHRFQKtc.....
A0A093F2M0_TYTAL/375-398             ....RQQ.AKRMARARRYLMENKTCQCQ-----q......
CD4_PANTR/425-453                    ...rRRQ.AQRMSQIKRLLSEKKTCQCPHRFQK.......
A0A5E4B7B3_MARMO/393-421             ...rRRQ.AERMSQIKRLLSEKKTCQCSHRLQK.......
M7B2Z9_CHEMY/377-400                 ....RQR.AEKMAQARRDLFERRTCQCQR----.......
A0A091J8V4_EGRGA/374-397             ....RQR.ARRMARARQYLLENKTCQCQ-----q......
A0A2R9B4G7_PANPA/425-453             ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A6MAP0_MONDO/435-461                 ..rl-RR.AERMSQIRRLLSEKKTCQCPHR---f......
A0A2K6DWJ0_MACNE/425-453             ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A212CD61_CEREH/375-398             ....RRQ.AQRMSQIKRLLSEKKTCQC------pq.....
A0A663F402_AQUCH/441-464             ....RQR.AKRMARARQYLLENKTCQCQ-----q......
A0A1D5PK32_CHICK/412-439             ....RKR.ARRMAQAKQYLLEKKTCQCQRRMYK.......
F6XGD3_MACMU/422-453                 cqhrRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A093S7H6_PHACA/372-395             ....RQR.AKRMAQARQYLLENKTCQCQ-----q......
A0A383Z543_BALAS/422-450             ...rRRQ.AERMSQIKTLLSEKKTCHCSHRLQK.......
A0A672U0G2_STRHB/415-440             .rrq-QR.RKRMAQARQYLLENKTCQCQR----.......
A0A2U3Y2Q1_LEPWE/429-457             ...rRRQ.AERMSQIKRLLSEKKTCQCSHRFQK.......
A0A341AHR6_NEOAA/423-450             ....RRR.AERTSQIKRLLSEKKTCHCSHRLQK.......
A0A2K5K7H1_COLAP/425-453             ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
L8HVB0_9CETA/423-446                 ....RRR.AERMSQIKRLLSEKKPCQC------pq.....
CD4_MACFA/425-453                    ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
U3JQ50_FICAL/460-487                 ....RQR.AKRMAQARQYLLENKTCQCQHRLKK.......
CD4_RABIT/427-454                    ....RHQ.AQRMSQIKKLLSEKKTCQCPHRLQK.......
A0A099Z1Z0_TINGU/377-400             ....RQR.AKRMALARQHLLENRTCQCK-----q......
G3QL31_GORGO/425-453                 ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A452IQE6_9SAUR/449-475             ....RRR.AEKMAQARRDLIERRICQCQRQ---lk.....
G1QXL1_NOMLE/425-453                 ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A091KB69_COLST/375-398             ....RQR.AKRMARARQHLLENKTCQCQ-----q......
A0A093CSY3_TAUER/375-398             ....RQR.AKKMARARQYLLENKTCQCQ-----q......
A0A2Y9E6V4_TRIMA/434-461             ....RRQ.AERMSQIKKLLSEKKTCQCSHRLQK.......
A0A2Y9KWP3_ENHLU/430-458             ...rRRQ.AARMSQIKRLLSEKKTCQCPHRLQK.......
H0ZSV2_TAEGU/369-396                 ....RQR.AKRMAQARQYLLENKTCQCQHRLKK.......
A0A452E3R1_CAPHI/422-450             ...rRRQ.AERMSQIKRLLSEKKTCQCPHRLQK.......
A0A091LFM8_CATAU/376-399             ....RQR.AKRMARARQHLLENKTCQCQ-----q......
CD4_MOUSE/425-452                    ...q-RQ.AARMSQIKRLLSEKKTCQCPHRMQK.......
A0A2K6NUB6_RHIRO/425-453             ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A091UPT0_NIPNI/375-398             ....RQR.AKRMARARQYLLENKTCQCQ-----q......
F7ILX9_CALJA/424-452                 ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A2K5E3A9_AOTNA/424-452             ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
V8PDS0_OPHHA/367-392                 ..qq--Q.AKRMAQIKQHLLAKRTCQCQR----dl.....
G1QAX4_MYOLU/425-447                 ...rRRQ.AVRMSQIKRLLSEKKTCQC------.......
A0A672TZQ4_STRHB/443-467             .rrq-QR.RKRMAQARQYLLENKT---------sprm...
A0A2Y9RYS9_TRIMA/434-458             ....RRQ.AERMSQIKKLLSEKKTCQCS-----ql.....
S7N841_MYOBR/430-454                 ...rRRQ.AVRMSQIKRLLSEKKTCQC------pq.....
A0A099ZZE9_CHAVO/375-398             ....RQR.AKRMVRARQYLLENKTCQCQ-----q......
L5M931_MYODS/427-455                 ...rRRQ.AVRMSQIKRLLSEKKTCQCPHRFQK.......
A0A2I0MLQ8_COLLI/448-475             ....RQR.AKRMVQARQYLLENKTCQCQHRLNK.......
A0A1S3WTS2_ERIEU/421-449             ...rRRQ.AERMSQIKRLLREKKTCQCSHRLQK.......
G7PJN3_MACFA/425-453                 ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A4W2CPG8_BOBOX/423-450             ....RRR.AERMSQIKRLLSEKKTCQCPHRLQK.......
A0A663F4F2_AQUCH/432-455             ....RQR.AKRMARARQYLLENKTCQCQ-----q......
A0A2I0U4I8_LIMLA/453-478             ....RQR.AKRMTQARQYLLENKTCQCQH----ll.....
A0A091S3U4_NESNO/375-398             ....RQR.RKRMAQARQYLLENKTCQCQR----.......
A0A1V4JB63_PATFA/454-481             ....RQR.AKRMVQARQYLLENKTCQCQHRLNK.......
A0A3L8S9T8_CHLGU/460-487             ....RQR.AKRMAQARQYLLENKTCQCQHRLKK.......
G5CAQ9_HETGA/410-433                 ..rq-RR.AARMSQIKRLLSEKKTCQC------p......
A0A087RHA1_APTFO/375-398             ....RQR.AKRMARARQYLLENKTCQCQ-----q......
A0A2Y9RUH9_TRIMA/434-459             ....RRQ.AERMSQIKKLLSEKKTCQCS-----qnl....
A0A663F3B4_AQUCH/453-476             ....RQR.AKRMARARQYLLENKTCQCQ-----q......
A0A2K5E3B4_AOTNA/371-399             ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A0D9RD08_CHLSB/527-555             ...rRRQ.AQRMSQIKRLLSEKKTCQCPHRFQK.......
A0A091VVS5_OPIHO/375-398             ....RQR.AKTMARARQYLLENKTCQCQ-----q......
A0A340Y8J8_LIPVE/422-449             ....RRR.AERTSQIKRLLSEKKTCHCSHRLQK.......
G1M645_AILME/380-408                 ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A485MFW6_LYNPA/437-465             ...rRRQ.AARMSHIKRLLSEKKTCQCSHRLQK.......
L5KFG2_PTEAL/351-375                 ....RKRqAERMSQIKRLLSEKKTCQC------pq.....
I6LI22_MUSPF/429-457                 ...rRRQ.AARMSQIKRLLSEKKTCQCPHRLQK.......
A0A093RTI8_9PASS/366-389             ....RQR.AKRMAQARQYLLENKTCQCQ-----q......
A0A091MUG6_CARIC/375-398             ....RQR.AKRMARARQYLLENKTCQCQ-----q......
K7G8F0_PELSI/431-457                 ....RRR.AERMVRARRDLIERRTCQCQFFM--v......
A0A091L1Z6_9GRUI/374-397             ....RQR.AKRMVRARQYLLENKTCQCQ-----q......
A0A4X2JRA7_VOMUR/440-466             ..rl-RR.AERMSQIRRLLSEKKTCQCPHR---f......
CD4_MACNE/425-453                    ...rRRQ.AERMSQIKRLLSEKKTCQCP-----hwfqk..
H0VL66_CAVPO/440-465                 ....RRQ.AARMSQIKRLLSEKKTCQCHR----ps.....
A0A5E4B698_MARMO/420-448             ...rRRQ.AERMSQIKRLLSEKKTCQCSHRLQK.......
A0A2K6M3L9_RHIBE/425-453             ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A091UGP9_PHORB/375-398             ....RQR.AKRMAQARQYLLENKTCQCQ-----q......
CD4_HUMAN/425-453                    ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
#=GR CD4_HUMAN/425-453         SS    ...XSSS.XTTHHTTSCSHHSSSSXXXXXSXXX.......
A0A6J3S3P7_TURTR/423-450             ....RRR.AQRTSQIKRLLSEKKTCHCSHRLQK.......
CD4_RAT/425-452                      ...q-RQ.AARMSQIKRLLSEKKTCQCSHRMQK.......
G1NMU4_MELGA/461-488                 ....RKR.AKRIAQAKQYLLEKKTCQCQRRMYK.......
A0A670JTE6_PODMU/284-310             ....RQR.ARRMAQARQHLLEKKTCQCHR----dlt....
F1NGI9_CHICK/460-487                 ....RKR.ARRMAQAKQYLLEKKTCQCQRRMYK.......
G3GUN9_CRIGR/424-447                 ....RRQ.AERMSQIKRLLSEKKTCQCS-----q......
A0A091PM83_HALAL/372-395             ....RQR.AKRMARARQYLLENKTCQCQ-----q......
A0A5F8A870_MACMU/246-274             ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A091RAA2_MERNU/375-398             ....RQR.AKRMAQARQYLLENKTCQCR-----q......
A0A2K5RGR6_CEBCA/424-452             ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
I3L556_PIG/462-489                   ....RRR.AERMSQIKRLLSEKKTCQCAHRQ--qk.....
H2NG98_PONAB/381-409                 ...rRRQ.AERMSQIKRLLSEKKTCQCPHRFQK.......
A0A091MIH9_9PASS/370-393             ....RQR.AKRMALAREYLLENKTCQCQ-----q......
G1T4B9_RABIT/427-454                 ....RHQ.AQRMSQIKKLLSEKKTCQCPHRLQK.......
A0A091I8Q3_CALAN/373-396             ....RQR.AKRMAQARQYLRENKRCQCQ-----q......
#=GC SS_cons                         ...XSSS.XTTHHTTSCSHHSSSSXXXXXSXXX.......
#=GC seq_cons                        ....R+p.AcRMuQhK+hL.EKKTCQCp+...........
//
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