LinkDB: Tcell_CD4_C
Original site: Tcell_CD4_C
Gene (366) KEGG GENES (366) Protein sequence (262) UniProt (249) SWISS-PROT (13) 3D Structure (6) PDB (6) Protein domain (2) InterPro (1) NCBI-CDD (1) Literature (1) PubMed (1) All databases (637)
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#=GF ID Tcell_CD4_C #=GF AC PF12104.8 #=GF DE T cell CD4 receptor C terminal region #=GF PI Tcell_CD4_Cterm; #=GF AU Mistry J;0000-0003-2479-5322 #=GF AU Gavin OL; #=GF SE pdb_1q68 #=GF GA 20.60 20.60; #=GF TC 21.30 20.60; #=GF NC 18.20 17.30; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF RN [1] #=GF RM 14500983 #=GF RT A zinc clasp structure tethers Lck to T cell coreceptors CD4 and #=GF RT CD8. #=GF RA Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ; #=GF RL Science. 2003;301:1725-1728. #=GF DR INTERPRO; IPR021963; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC This domain is the C terminal domain of the CD4 T cell receptor. #=GF CC The C terminal domain is the cytoplasmic domain which relays the #=GF CC signal for T cell activation. This process involves co-receptor #=GF CC internalisation. This domain is involved in binding to the N #=GF CC terminal of Lck co-receptor in a Zn2+ clasp structure. #=GF SQ 101 #=GS A0A091H214_BUCRH/375-398 AC A0A091H214.1 #=GS CD4_MACMU/426-453 AC P16003.2 #=GS F7I777_CALJA/153-180 AC F7I777.1 #=GS A0A093HUX7_STRCA/376-399 AC A0A093HUX7.1 #=GS A0A091KB69_COLST/375-398 AC A0A091KB69.1 #=GS A0A0D9RD08_CHLSB/528-555 AC A0A0D9RD08.1 #=GS F7AB77_MONDO/344-369 AC F7AB77.2 #=GS A0A093CSY3_TAUER/375-398 AC A0A093CSY3.1 #=GS L8Y3X9_TUPCH/436-459 AC L8Y3X9.1 #=GS A0A091LFM8_CATAU/376-399 AC A0A091LFM8.1 #=GS CD4_MOUSE/425-452 AC P06332.1 #=GS W5P8J4_SHEEP/513-527 AC W5P8J4.1 #=GS A0A091PV80_LEPDC/375-398 AC A0A091PV80.1 #=GS F6WG07_ORNAN/478-499 AC F6WG07.2 #=GS U3I4I6_ANAPL/455-482 AC U3I4I6.1 #=GS A0A091UPT0_NIPNI/375-398 AC A0A091UPT0.1 #=GS V8PDS0_OPHHA/367-392 AC V8PDS0.1 #=GS A0A091EII6_CORBR/372-397 AC A0A091EII6.1 #=GS G7PJN3_MACFA/426-453 AC G7PJN3.1 #=GS S7N841_MYOBR/431-454 AC S7N841.1 #=GS G3QL31_GORGO/426-453 AC G3QL31.1 #=GS F1SLT5_PIG/425-452 AC F1SLT5.1 #=GS A0A1A6HFA7_NEOLE/369-392 AC A0A1A6HFA7.1 #=GS H9GAP5_ANOCA/1-24 AC H9GAP5.1 #=GS A0A091SDT1_9GRUI/375-398 AC A0A091SDT1.1 #=GS A0A099ZZE9_CHAVO/375-398 AC A0A099ZZE9.1 #=GS A0A091GEQ9_9AVES/374-397 AC A0A091GEQ9.1 #=GS A0A2I0MLQ8_COLLI/448-475 AC A0A2I0MLQ8.1 #=GS A0A1S3WTS2_ERIEU/422-449 AC A0A1S3WTS2.1 #=GS H0VL66_CAVPO/440-464 AC H0VL66.2 #=GS CD4_PANTR/426-453 AC P16004.1 #=GS A0A093IJ13_DRYPU/375-398 AC A0A093IJ13.1 #=GS G1QAX4_MYOLU/426-447 AC G1QAX4.1 #=GS A0A091S3U4_NESNO/375-398 AC A0A091S3U4.1 #=GS A0A093C2M2_9AVES/375-398 AC A0A093C2M2.1 #=GS A0A1V4JB63_PATFA/454-481 AC A0A1V4JB63.1 #=GS G1M645_AILME/381-408 AC G1M645.1 #=GS A0A093FFP9_GAVST/374-397 AC A0A093FFP9.1 #=GS A0A2I2UV30_FELCA/448-475 AC A0A2I2UV30.1 #=GS I6LI22_MUSPF/430-457 AC I6LI22.1 #=GS H0XBR4_OTOGA/343-370 AC H0XBR4.1 #=GS G3UBY8_LOXAF/417-444 AC G3UBY8.1 #=GS A0A087RHA1_APTFO/375-398 AC A0A087RHA1.1 #=GS A0A093INP9_FULGA/375-398 AC A0A093INP9.1 #=GS G3U7C0_LOXAF/417-445 AC G3U7C0.1 #=GS A0A093N9B7_PYGAD/375-398 AC A0A093N9B7.1 #=GS G3UCG3_LOXAF/417-450 AC G3UCG3.1 #=GS CD4_CANLF/431-458 AC P33705.1 #=GS A0A091VVS5_OPIHO/375-398 AC A0A091VVS5.1 #=GS A0A093JFH7_EURHL/373-396 AC A0A093JFH7.1 #=GS G3WTA4_SARHA/460-485 AC G3WTA4.1 #=GS H2NG98_PONAB/382-409 AC H2NG98.1 #=GS A0A091SDM9_9AVES/372-395 AC A0A091SDM9.1 #=GS A0A093F2M0_TYTAL/375-398 AC A0A093F2M0.1 #=GS A0A093RTI8_9PASS/366-389 AC A0A093RTI8.1 #=GS A0A091MUG6_CARIC/375-398 AC A0A091MUG6.1 #=GS A0A091J8V4_EGRGA/374-397 AC A0A091J8V4.1 #=GS I3NES8_ICTTR/419-446 AC I3NES8.1 #=GS M7B2Z9_CHEMY/377-400 AC M7B2Z9.1 #=GS G5CAQ9_HETGA/407-433 AC G5CAQ9.1 #=GS K7G8F0_PELSI/431-457 AC K7G8F0.1 #=GS A0A091L1Z6_9GRUI/374-397 AC A0A091L1Z6.1 #=GS A0A2K5K7H1_COLAP/426-453 AC A0A2K5K7H1.1 #=GS W5P8J5_SHEEP/432-450 AC W5P8J5.1 #=GS A0A151MCU8_ALLMI/518-546 AC A0A151MCU8.1 #=GS A0A096MWA4_PAPAN/426-453 AC A0A096MWA4.1 #=GS L5KFG2_PTEAL/348-375 AC L5KFG2.1 #=GS G1QXL1_NOMLE/426-453 AC G1QXL1.1 #=GS F1SLT4_PIG/401-428 AC F1SLT4.2 #=GS A0A091UGP9_PHORB/375-398 AC A0A091UGP9.1 #=GS G3ULS8_LOXAF/434-467 AC G3ULS8.1 #=GS A0A093S7H6_PHACA/372-395 AC A0A093S7H6.1 #=GS G3TZC2_LOXAF/429-456 AC G3TZC2.1 #=GS A0A091CQ95_FUKDA/850-873 AC A0A091CQ95.1 #=GS F6Y6X8_HORSE/429-456 AC F6Y6X8.1 #=GS CD4_RAT/425-452 AC P05540.1 #=GS G1NMU4_MELGA/461-488 AC G1NMU4.2 #=GS A0A151MBR4_ALLMI/74-95 AC A0A151MBR4.1 #=GS G3GUN9_CRIGR/424-447 AC G3GUN9.1 #=GS F1NGI9_CHICK/460-487 AC F1NGI9.1 #=GS F1MJK4_BOVIN/423-449 AC F1MJK4.2 #=GS F7ILX9_CALJA/358-385 AC F7ILX9.1 #=GS M3W1W4_FELCA/442-469 AC M3W1W4.2 #=GS A0A1D5PK32_CHICK/460-486 AC A0A1D5PK32.1 #=GS A0A091PM83_HALAL/372-395 AC A0A091PM83.1 #=GS A0A0G3FB31_CERAT/426-453 AC A0A0G3FB31.1 #=GS G3TWZ4_LOXAF/426-452 AC G3TWZ4.1 #=GS A0A091RAA2_MERNU/375-398 AC A0A091RAA2.1 #=GS L5M931_MYODS/428-455 AC L5M931.1 #=GS A0A1U8DZG6_ALLSI/458-486 AC A0A1U8DZG6.1 #=GS A0A1U7Q3K5_MESAU/367-394 AC A0A1U7Q3K5.1 #=GS CD4_HUMAN/426-453 AC P01730.1 #=GS CD4_HUMAN/426-453 DR PDB; 3B71 E; 406-416; #=GS CD4_HUMAN/426-453 DR PDB; 2JKT Q; 2-10; #=GS CD4_HUMAN/426-453 DR PDB; 1WBR A; 403-419; #=GS CD4_HUMAN/426-453 DR PDB; 2JKR Q; 2-10; #=GS CD4_HUMAN/426-453 DR PDB; 3B71 D; 406-416; #=GS CD4_HUMAN/426-453 DR PDB; 2JKR P; 2-10; #=GS CD4_HUMAN/426-453 DR PDB; 2KLU A; 401-428; #=GS CD4_HUMAN/426-453 DR PDB; 3B71 F; 408-416; #=GS CD4_HUMAN/426-453 DR PDB; 1Q68 A; 401-428; #=GS CD4_HUMAN/426-453 DR PDB; 2JKT P; 2-10; #=GS I3L556_PIG/462-489 AC I3L556.2 #=GS A0A091I8Q3_CALAN/373-396 AC A0A091I8Q3.1 #=GS G1T4B9_RABIT/427-454 AC G1T4B9.1 #=GS U3JQ50_FICAL/460-487 AC U3JQ50.1 #=GS A0A091MIH9_9PASS/370-393 AC A0A091MIH9.1 #=GS H0ZSV2_TAEGU/374-403 AC H0ZSV2.1 #=GS CD4_RABIT/427-454 AC P46630.1 #=GS F6XGD3_MACMU/426-450 AC F6XGD3.2 #=GS A0A099Z1Z0_TINGU/377-400 AC A0A099Z1Z0.1 A0A091H214_BUCRH/375-398 ...........RQQAKKMARARRYLLENKTCQCQ.-..----q... CD4_MACMU/426-453 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK.... F7I777_CALJA/153-180 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK.... A0A093HUX7_STRCA/376-399 ...........RQRAKRMALARQHLLENRTCQCQ.-..----q... A0A091KB69_COLST/375-398 ...........RQRAKRMARARQHLLENKTCQCQ.-..----q... A0A0D9RD08_CHLSB/528-555 ...........RRQAQRMSQIKRLLSEKKTCQCP.H..RFQK.... F7AB77_MONDO/344-369 ..........l-RRAERMSQIRRLLSEKKTCQCP.H..RF--.... A0A093CSY3_TAUER/375-398 ...........RQRAKKMARARQYLLENKTCQCQ.-..----q... L8Y3X9_TUPCH/436-459 ...........RRQAERMSQIKRLLKEKKPCQCS.-..----q... A0A091LFM8_CATAU/376-399 ...........RQRAKRMARARQHLLENKTCQCQ.-..----q... CD4_MOUSE/425-452 ..........q-RQAARMSQIKRLLSEKKTCQCP.H..RMQK.... W5P8J4_SHEEP/513-527 ..........p----------KRLLSEKKTCQCP.-..----q... A0A091PV80_LEPDC/375-398 ...........RQRAKKMARARQYLLENKTCQCQ.-..----q... F6WG07_ORNAN/478-499 ..........q-QRAERVSQIRRLLKDNKTCQC-.-..----.... U3I4I6_ANAPL/455-482 ...........RQRAKRMARARQYLLEKKTCQCQ.H..RMNK.... A0A091UPT0_NIPNI/375-398 ...........RQRAKRMARARQYLLENKTCQCQ.-..----q... V8PDS0_OPHHA/367-392 ..........q-QQAKRMAQIKQHLLAKRTCQCQ.R..----dl.. A0A091EII6_CORBR/372-397 ........rrm-QRRKRMAQARQYLLENKTCQCQ.-..----q... G7PJN3_MACFA/426-453 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK.... S7N841_MYOBR/431-454 ...........RRQAVRMSQIKRLLSEKKTCQCP.-..----q... G3QL31_GORGO/426-453 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK.... F1SLT5_PIG/425-452 ...........RRRAERMSQIKRLLSEKKTCQCA.H..RQQK.... A0A1A6HFA7_NEOLE/369-392 ..........q-RQAERMSQIKRLLSEKKTCQCS.-..----q... H9GAP5_ANOCA/1-24 ..........q-QRARRMAQAKQHLLEKKTCQCE.R..----.... A0A091SDT1_9GRUI/375-398 ...........RQQAKRMIRARQHLLENKTCQCQ.-..----q... A0A099ZZE9_CHAVO/375-398 ...........RQRAKRMVRARQYLLENKTCQCQ.-..----q... A0A091GEQ9_9AVES/374-397 ...........RQRARRMARARQYLLENKTCQCR.-..----q... A0A2I0MLQ8_COLLI/448-475 ...........RQRAKRMVQARQYLLENKTCQCQ.H..RLNK.... A0A1S3WTS2_ERIEU/422-449 ...........RRQAERMSQIKRLLREKKTCQCS.H..RLQK.... H0VL66_CAVPO/440-464 ...........RRQAARMSQIKRLLSEKKTCQCH.R..----p... CD4_PANTR/426-453 ...........RRQAQRMSQIKRLLSEKKTCQCP.H..RFQK.... A0A093IJ13_DRYPU/375-398 ...........RQRARKMAQARQYLLENKTCQCH.-..----q... G1QAX4_MYOLU/426-447 ...........RRQAVRMSQIKRLLSEKKTCQC-.-..----.... A0A091S3U4_NESNO/375-398 ...........RQRRKRMAQARQYLLENKTCQCQ.R..----.... A0A093C2M2_9AVES/375-398 ...........RQRAKRMARARQYLLENKTCQCQ.-..----q... A0A1V4JB63_PATFA/454-481 ...........RQRAKRMVQARQYLLENKTCQCQ.H..RLNK.... G1M645_AILME/381-408 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK.... A0A093FFP9_GAVST/374-397 ...........RQRAKRMARARQYLLENKTCQCQ.-..----q... A0A2I2UV30_FELCA/448-475 ...........RRQAARMSHIKRLLSEKKTCQCS.H..RLQK.... I6LI22_MUSPF/430-457 ...........RRQAARMSQIKRLLSEKKTCQCP.H..RLQK.... H0XBR4_OTOGA/343-370 ...........RRQTERKSQIKRLLSEKKTCQCV.H..RFQK.... G3UBY8_LOXAF/417-444 ..rrrvseppq------MSQIKRLLSEKKTCQCP.-..----sk.. A0A087RHA1_APTFO/375-398 ...........RQRAKRMARARQYLLENKTCQCQ.-..----q... A0A093INP9_FULGA/375-398 ...........RQRAKRMAQARQYLLENKTCQCQ.-..----q... G3U7C0_LOXAF/417-445 ...........RHQRRRMSQIKRLLSEKKTCQCPsN..RLQK.... A0A093N9B7_PYGAD/375-398 ...........RQRAKRMARARQYLLENKTCQCQ.-..----q... G3UCG3_LOXAF/417-450 rhqrrrvsepp------MSQIKRLLSEKKTCQCPsN..RLQK.... CD4_CANLF/431-458 ...........RRQAERMSQIKRLLSEKKTCQCS.H..RIQK.... A0A091VVS5_OPIHO/375-398 ...........RQRAKTMARARQYLLENKTCQCQ.-..----q... A0A093JFH7_EURHL/373-396 ...........RQRAKRMARARQYLLENKTCQCQ.-..----q... G3WTA4_SARHA/460-485 ..........l-RRAERMSQIRRLLSEKKTCQCP.H..HF--.... H2NG98_PONAB/382-409 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK.... A0A091SDM9_9AVES/372-395 ...........RQRVKRMARARQLLLEKKTCQCQ.-..----q... A0A093F2M0_TYTAL/375-398 ...........RQQAKRMARARRYLMENKTCQCQ.-..----q... A0A093RTI8_9PASS/366-389 ...........RQRAKRMAQARQYLLENKTCQCQ.-..----q... A0A091MUG6_CARIC/375-398 ...........RQRAKRMARARQYLLENKTCQCQ.-..----q... A0A091J8V4_EGRGA/374-397 ...........RQRARRMARARQYLLENKTCQCQ.-..----q... I3NES8_ICTTR/419-446 ...........RRQAERMSQIKRLLSEKKTCQCS.H..RLQK.... M7B2Z9_CHEMY/377-400 ...........RQRAEKMAQARRDLFERRTCQCQ.R..----.... G5CAQ9_HETGA/407-433 ......crhrq-RRAARMSQIKRLLSEKKTCQCP.-..----.... K7G8F0_PELSI/431-457 ...........RRRAERMVRARRDLIERRTCQCQ.-..----ffmv A0A091L1Z6_9GRUI/374-397 ...........RQRAKRMVRARQYLLENKTCQCQ.-..----q... A0A2K5K7H1_COLAP/426-453 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK.... W5P8J5_SHEEP/432-450 ..........p----------KRLLSEKKTCQCP.H..RLQK.... A0A151MCU8_ALLMI/518-546 .........rk-RRAKRMVRVRRDLLENRMCQCQ.H..RL--rn.. A0A096MWA4_PAPAN/426-453 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK.... L5KFG2_PTEAL/348-375 ......crhrk-RQAERMSQIKRLLSEKKTCQCP.-..----q... G1QXL1_NOMLE/426-453 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK.... F1SLT4_PIG/401-428 ..........q-RRAERMSQIKRLLSEKKTCQCA.H..RQQK.... A0A091UGP9_PHORB/375-398 ...........RQRAKRMAQARQYLLENKTCQCQ.-..----q... G3ULS8_LOXAF/434-467 rhqrrrvsepp------MSQIKRLLSEKKTCQCPsN..RLQK.... A0A093S7H6_PHACA/372-395 ...........RQRAKRMAQARQYLLENKTCQCQ.-..----q... G3TZC2_LOXAF/429-456 ..rrrvseppq------MSQIKRLLSEKKTCQCP.-..----sk.. A0A091CQ95_FUKDA/850-873 ..........q-RRAEQMSQIKRLLSEKKTCQCS.-..----q... F6Y6X8_HORSE/429-456 ...........RRQAERMSQIKRLLSEKKTCQCH.H..RFQK.... CD4_RAT/425-452 ..........q-RQAARMSQIKRLLSEKKTCQCS.H..RMQK.... G1NMU4_MELGA/461-488 ...........RKRAKRIAQAKQYLLEKKTCQCQ.R..RMYK.... A0A151MBR4_ALLMI/74-95 .........ss--------YAKNTIQEKQTCQCS.H..RSV-k... G3GUN9_CRIGR/424-447 ...........RRQAERMSQIKRLLSEKKTCQCS.-..----q... F1NGI9_CHICK/460-487 ...........RKRARRMAQAKQYLLEKKTCQCQ.R..RMYK.... F1MJK4_BOVIN/423-449 ...........RRRAERMSQIKRLLSEKKTCQCP.H..----eaq. F7ILX9_CALJA/358-385 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK.... M3W1W4_FELCA/442-469 ...........RRQAARMSHIKRLLSEKKTCQCS.H..RLQK.... A0A1D5PK32_CHICK/460-486 ...........RKRARRMAQAKQYLLEKKTCQCQ.R..----lqq. A0A091PM83_HALAL/372-395 ...........RQRAKRMARARQYLLENKTCQCQ.-..----q... A0A0G3FB31_CERAT/426-453 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK.... G3TWZ4_LOXAF/426-452 .......ppqx------MSQIKRLLSEKKTCQCPsN..RLQK.... A0A091RAA2_MERNU/375-398 ...........RQRAKRMAQARQYLLENKTCQCR.-..----q... L5M931_MYODS/428-455 ...........RRQAVRMSQIKRLLSEKKTCQCP.H..RFQK.... A0A1U8DZG6_ALLSI/458-486 .........rk-RRAKRMVRVRRDLLENRTCQCQ.H..RL--rn.. A0A1U7Q3K5_MESAU/367-394 ...........RRQAERMSQIKRLLSEKKTCQCS.H..RMQK.... CD4_HUMAN/426-453 ...........RRQAERMSQIKRLLSEKKTCQCP.H..RFQK.... #=GR CD4_HUMAN/426-453 SS ...........SSSXTTHHCHHHHHHSSSSXXXX.X..SXXX.... I3L556_PIG/462-489 ...........RRRAERMSQIKRLLSEKKTCQCA.H..RQQK.... A0A091I8Q3_CALAN/373-396 ...........RQRAKRMAQARQYLRENKRCQCQ.-..----q... G1T4B9_RABIT/427-454 ...........RHQAQRMSQIKKLLSEKKTCQCP.H..RLQK.... U3JQ50_FICAL/460-487 ...........RQRAKRMAQARQYLLENKTCQCQ.H..RLKK.... A0A091MIH9_9PASS/370-393 ...........RQRAKRMALAREYLLENKTCQCQ.-..----q... H0ZSV2_TAEGU/374-403 ...........RQRAKRMAQARQYLLENKTCQCQ.QapRMGK.... CD4_RABIT/427-454 ...........RHQAQRMSQIKKLLSEKKTCQCP.H..RLQK.... F6XGD3_MACMU/426-450 ...........RRQAERMSQIKRLLSEKKTCQCP.H..----l... A0A099Z1Z0_TINGU/377-400 ...........RQRAKRMALARQHLLENRTCQCK.-..----q... #=GC SS_cons ...........SSSXTTHHCHHHHHHSSSSXXXX.X..SXXX.... #=GC seq_cons ...........RppAcRMuQh+phL.E+KTCQCp............ //