GenomeNet

Database: Pfam
Entry: TetR_C_15
LinkDB: TetR_C_15
Original site: TetR_C_15 
#=GF ID   TetR_C_15
#=GF AC   PF17918.2
#=GF DE   Tetracyclin repressor-like, C-terminal domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF03130
#=GF GA   26.80 26.80;
#=GF TC   26.80 26.80;
#=GF NC   26.70 26.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   15944459
#=GF RT   The TetR family of transcriptional repressors.
#=GF RA   Ramos JL, Martinez-Bueno M, Molina-Henares AJ, Teran W, Watanabe
#=GF RA   K, Zhang X, Gallegos MT, Brennan R, Tobes R;
#=GF RL   Microbiol Mol Biol Rev. 2005;69:326-356. 
#=GF RN   [2]
#=GF RM   27091999
#=GF RT   Structures of the nucleoid occlusion protein SlmA bound to DNA
#=GF RT   and the C-terminal domain of the cytoskeletal protein FtsZ.
#=GF RA   Schumacher MA, Zeng W;
#=GF RL   Proc Natl Acad Sci U S A. 2016;113:4988-4993.
#=GF RN   [3]
#=GF RM   7707374
#=GF RT   The complex formed between Tet repressor and tetracycline-Mg2+
#=GF RT   reveals mechanism        of antibiotic resistance.
#=GF RA   Kisker C, Hinrichs W, Tovar K, Hillen W, Saenger W;
#=GF RL   J Mol Biol. 1995;247:260-280.
#=GF DR   INTERPRO; IPR041669;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   TetR family regulators are involved in the transcriptional
#=GF CC   control of multidrug efflux pumps, pathways for the biosynthesis
#=GF CC   of antibiotics, response to osmotic stress and toxic chemicals,
#=GF CC   control of catabolic pathways, differentiation processes, and
#=GF CC   pathogenicity [1]. The TetR proteins identified in overm ultiple
#=GF CC   genera of bacteria and archaea share a common helix-turn-helix
#=GF CC   (HTH) structure in their DNA-binding domain. However, TetR
#=GF CC   proteins can work in different ways: they can bind a target
#=GF CC   operator directly to exert their effect (e.g. TetR binds Tet(A)
#=GF CC   gene to repress it in the absence of tetracycline), or they can
#=GF CC   be involved in complex regulatory cascades in which the TetR
#=GF CC   protein can either be modulated by another regulator or TetR can
#=GF CC   trigger the cellular response. This entry represents the
#=GF CC   C-terminal domain found in a number of different TetR
#=GF CC   transcription regulator proteins including SlmA proteins found
#=GF CC   in E. coli. Unlike other TetR proteins, SlmA functions not as a
#=GF CC   transcription regulator but rather as an NO (nucleoid occlusion)
#=GF CC   factor [2]. TetR regulates the expression of the
#=GF CC   membrane-associated tetracycline resistance protein, TetA, which
#=GF CC   exports the tetracycline antibiotic out of the cell before it
#=GF CC   can attach to the ribosomes and inhibit protein synthesis [3].
#=GF CC   TetR blocks transcription from the genes encoding both TetA and
#=GF CC   TetR in the absence of antibiotic. The C-terminal domain is
#=GF CC   multi-helical and is interlocked in the homodimer with the
#=GF CC   helix-turn-helix (HTH) DNA-binding domain [3].
#=GF SQ   1011
#=GS Q89MG3_BRADU/95-204       AC Q89MG3.1
#=GS A0A0B5DZC5_9RHOB/76-184   AC A0A0B5DZC5.1
#=GS K9U816_CHRTP/105-212      AC K9U816.1
#=GS A0A2W7FPM4_9BURK/92-195   AC A0A2W7FPM4.1
#=GS A0A370B5A8_9ACTN/99-206   AC A0A370B5A8.1
#=GS A0A1A1YD08_9MYCO/84-184   AC A0A1A1YD08.1
#=GS A0A2G5PGR7_9MYCO/84-187   AC A0A2G5PGR7.1
#=GS A0A2S5TH13_9GAMM/99-207   AC A0A2S5TH13.1
#=GS Q82CL2_STRAW/116-223      AC Q82CL2.1
#=GS W5W0H2_9PSEU/92-196       AC W5W0H2.1
#=GS A5V7D9_SPHWW/126-235      AC A5V7D9.1
#=GS A0A1E8Q3J4_9MYCO/84-186   AC A0A1E8Q3J4.1
#=GS A0A0C4Y8W3_9BURK/91-201   AC A0A0C4Y8W3.1
#=GS A0A261GS31_9GAMM/90-191   AC A0A261GS31.1
#=GS A0A0C2QDU1_9CYAN/94-203   AC A0A0C2QDU1.1
#=GS Q1IUZ5_KORVE/97-204       AC Q1IUZ5.1
#=GS A0A139XCI7_9CYAN/87-194   AC A0A139XCI7.1
#=GS A0A1G6W9R9_9PSEU/101-205  AC A0A1G6W9R9.1
#=GS K9RLN1_9CYAN/98-203       AC K9RLN1.1
#=GS A0A1L6LKD3_9DELT/90-199   AC A0A1L6LKD3.1
#=GS V9XQB4_9NOCA/2-57         AC V9XQB4.1
#=GS A0A1H6DH98_9ACTN/89-205   AC A0A1H6DH98.1
#=GS G7CDB6_MYCT3/68-170       AC G7CDB6.1
#=GS A0A2L0W5P0_9RHIZ/49-157   AC A0A2L0W5P0.1
#=GS A0A157SF51_9BORD/96-204   AC A0A157SF51.1
#=GS W9AX75_9MYCO/95-200       AC W9AX75.1
#=GS A0A0N0NFZ6_9ACTN/74-183   AC A0A0N0NFZ6.1
#=GS A0A0K1PW94_9DELT/127-233  AC A0A0K1PW94.1
#=GS A0A1U9Z4R1_9RHIZ/97-204   AC A0A1U9Z4R1.1
#=GS A0A401ZMA0_9CHLR/104-211  AC A0A401ZMA0.1
#=GS A0A2T1DJ30_9CYAN/97-206   AC A0A2T1DJ30.1
#=GS A0A0B8NEW8_9NOCA/74-181   AC A0A0B8NEW8.1
#=GS A0A3P1SW31_9GAMM/109-216  AC A0A3P1SW31.1
#=GS A0A1Q4VMU4_9ACTN/96-201   AC A0A1Q4VMU4.1
#=GS A0A3M0IAR5_9ACTN/98-205   AC A0A3M0IAR5.1
#=GS A0A0F0HI73_NOCAE/87-194   AC A0A0F0HI73.1
#=GS A0A263DQH3_9PSEU/94-202   AC A0A263DQH3.1
#=GS A0A1I5SHJ5_9BURK/94-206   AC A0A1I5SHJ5.1
#=GS A0A120MW98_9CYAN/104-213  AC A0A120MW98.1
#=GS A0A0F5JXJ0_9BURK/96-204   AC A0A0F5JXJ0.1
#=GS A0A323V1M8_9RHOO/106-219  AC A0A323V1M8.1
#=GS A0A0Q8QF81_9SPHN/96-204   AC A0A0Q8QF81.1
#=GS U5RR00_9CLOT/92-201       AC U5RR00.1
#=GS A0A3N0GP93_9ACTN/98-204   AC A0A3N0GP93.1
#=GS K9QSS8_NOSS7/95-202       AC K9QSS8.1
#=GS F2LNY1_BURGS/94-200       AC F2LNY1.1
#=GS A0A0K1QDE2_9DELT/74-183   AC A0A0K1QDE2.1
#=GS A0A495RC12_SPHMI/95-204   AC A0A495RC12.1
#=GS A0A1Q4YSH8_9PSEU/1-100    AC A0A1Q4YSH8.1
#=GS A0A1I0IV08_9BACL/94-203   AC A0A1I0IV08.1
#=GS A0A2P2DJU0_9LEPT/100-208  AC A0A2P2DJU0.1
#=GS A0A0Q9AL55_9ACTN/95-200   AC A0A0Q9AL55.1
#=GS A0A1H3N7Z3_9RHOB/95-198   AC A0A1H3N7Z3.1
#=GS B7JYP1_RIPO1/99-207       AC B7JYP1.1
#=GS A0A429GBU2_9ACTN/94-203   AC A0A429GBU2.1
#=GS A0A2Z5G0K5_9BACT/81-189   AC A0A2Z5G0K5.1
#=GS A0A0P4V5N8_9CYAN/102-209  AC A0A0P4V5N8.1
#=GS A0A132T3Z2_9MYCO/100-202  AC A0A132T3Z2.1
#=GS A0A0Q8DK32_9ACTN/76-183   AC A0A0Q8DK32.1
#=GS A0A2T6E967_9GAMM/95-203   AC A0A2T6E967.1
#=GS A0A3N0VFZ9_9GAMM/102-211  AC A0A3N0VFZ9.1
#=GS A0A2I5T989_SERS3/96-204   AC A0A2I5T989.1
#=GS A0A0Q8PRI9_9ACTN/107-218  AC A0A0Q8PRI9.1
#=GS A0A1H8IGX0_9ACTN/91-199   AC A0A1H8IGX0.1
#=GS A0A162JX45_9ACTN/96-202   AC A0A162JX45.1
#=GS G7GQK2_9ACTN/97-203       AC G7GQK2.1
#=GS A0A3N0DRK7_9ACTN/102-208  AC A0A3N0DRK7.1
#=GS A0A1Z4K9Z8_9CYAN/98-206   AC A0A1Z4K9Z8.1
#=GS A0A0G3AJX8_9ACTN/95-200   AC A0A0G3AJX8.1
#=GS D2B6E5_STRRD/114-221      AC D2B6E5.1
#=GS A0A1E3RVK7_9MYCO/84-186   AC A0A1E3RVK7.1
#=GS A0A1H9M179_9GAMM/104-212  AC A0A1H9M179.1
#=GS A0A2T5MIP4_9GAMM/74-183   AC A0A2T5MIP4.1
#=GS A0A494XRS5_9BURK/86-192   AC A0A494XRS5.1
#=GS A0A089JVD6_9BACL/96-203   AC A0A089JVD6.1
#=GS A0A1X0Y5U9_9DELT/94-204   AC A0A1X0Y5U9.1
#=GS X7Y937_MYCKA/73-179       AC X7Y937.1
#=GS J3HI42_9BURK/96-199       AC J3HI42.1
#=GS G2IRL5_SPHSK/105-213      AC G2IRL5.1
#=GS A0A2M9JII9_9ACTN/95-199   AC A0A2M9JII9.1
#=GS A0A3D9FGW1_9SPHN/95-204   AC A0A3D9FGW1.1
#=GS A0A0N9I1Q5_9PSEU/95-203   AC A0A0N9I1Q5.1
#=GS A0A1Z2KUR8_9ACTN/101-209  AC A0A1Z2KUR8.1
#=GS A0A2S2FHA5_9GAMM/86-195   AC A0A2S2FHA5.1
#=GS A0A1Z2LEE1_9ACTN/101-207  AC A0A1Z2LEE1.1
#=GS A0A0A0DSS4_9BURK/62-171   AC A0A0A0DSS4.1
#=GS K5BCY9_MYCHD/68-171       AC K5BCY9.1
#=GS A0A1Q4VSS9_9ACTN/95-203   AC A0A1Q4VSS9.1
#=GS A0A0N0L449_9MICO/102-208  AC A0A0N0L449.1
#=GS A0A3A9YTX5_9ACTN/93-199   AC A0A3A9YTX5.1
#=GS A0A3N1DC37_9ACTN/101-210  AC A0A3N1DC37.1
#=GS N8XHS7_9GAMM/85-195       AC N8XHS7.1
#=GS A0A418KIZ3_9ACTN/70-177   AC A0A418KIZ3.1
#=GS D6U1M0_9CHLR/93-191       AC D6U1M0.1
#=GS A0A418UQR6_9ACTO/102-207  AC A0A418UQR6.1
#=GS A0A1B1PNG7_9RHOB/70-173   AC A0A1B1PNG7.1
#=GS A0A1M5KYE4_STRHI/74-181   AC A0A1M5KYE4.1
#=GS A0A089LP41_9BACL/98-206   AC A0A089LP41.1
#=GS A0A3P0X7J4_9BACT/97-204   AC A0A3P0X7J4.1
#=GS A0A132PP87_9MYCO/84-186   AC A0A132PP87.1
#=GS A0A3S8X078_9ACTN/94-202   AC A0A3S8X078.1
#=GS A1SNW1_NOCSJ/132-238      AC A1SNW1.1
#=GS A0A139VQU5_MYCPH/84-185   AC A0A139VQU5.1
#=GS A0A3N1MD10_9PROT/93-201   AC A0A3N1MD10.1
#=GS A0A1U7J7M8_9CYAN/97-205   AC A0A1U7J7M8.1
#=GS A0A2T4VV91_9DELT/127-234  AC A0A2T4VV91.1
#=GS A0A1W2DIP9_9DELT/94-202   AC A0A1W2DIP9.1
#=GS A0A031LNB0_9GAMM/86-195   AC A0A031LNB0.1
#=GS K9UFF7_CHAP6/94-202       AC K9UFF7.1
#=GS E0UMZ9_CYAP2/97-205       AC E0UMZ9.1
#=GS G0AEZ5_COLFT/150-251      AC G0AEZ5.1
#=GS A0A1C3MZB5_9ACTN/102-210  AC A0A1C3MZB5.1
#=GS A0A1M7RN09_9ACTN/91-197   AC A0A1M7RN09.1
#=GS A0A372FV56_9ACTN/75-182   AC A0A372FV56.1
#=GS A0A3N1QIZ4_9MICO/102-209  AC A0A3N1QIZ4.1
#=GS A0A3R7FZ18_9ACTN/134-241  AC A0A3R7FZ18.1
#=GS K0EV10_9NOCA/74-182       AC K0EV10.1
#=GS A0A365T411_9PSED/84-188   AC A0A365T411.1
#=GS A0A1H1KD49_9RHIZ/92-197   AC A0A1H1KD49.1
#=GS A0A1G9GA63_9ACTN/97-203   AC A0A1G9GA63.1
#=GS A0A1T4T4A2_9ACTN/92-199   AC A0A1T4T4A2.1
#=GS A0A386Z755_9NOCA/94-202   AC A0A386Z755.1
#=GS A0A2P7SAY0_9RHIZ/96-204   AC A0A2P7SAY0.1
#=GS A0A1I6MA24_9BACT/96-204   AC A0A1I6MA24.1
#=GS A0A2N5EJ59_9GAMM/95-201   AC A0A2N5EJ59.1
#=GS A0A0J7Y3A7_9SPHN/83-191   AC A0A0J7Y3A7.1
#=GS A0A1I5DNW7_9MICO/105-211  AC A0A1I5DNW7.1
#=GS A0A369WCV7_9GAMM/107-214  AC A0A369WCV7.1
#=GS C1AA70_GEMAT/124-236      AC C1AA70.1
#=GS A0A1C5FAK4_9ACTN/92-204   AC A0A1C5FAK4.1
#=GS A0A1I6AED7_9PSEU/93-201   AC A0A1I6AED7.1
#=GS A0A443YIX8_9DELT/95-202   AC A0A443YIX8.1
#=GS A0A0T2IHI8_9MICO/105-206  AC A0A0T2IHI8.1
#=GS A0A162SUY0_9BURK/96-204   AC A0A162SUY0.1
#=GS G6YAU7_9RHIZ/1-61         AC G6YAU7.1
#=GS A0A2T5G240_9SPHN/94-201   AC A0A2T5G240.1
#=GS A0A3S4SBK6_MYCCI/118-215  AC A0A3S4SBK6.1
#=GS A0A1V0A3W7_9ACTN/89-196   AC A0A1V0A3W7.1
#=GS A0A1D8T2H0_9NOCA/102-214  AC A0A1D8T2H0.1
#=GS A0A0C2MDM9_9CYAN/94-161   AC A0A0C2MDM9.1
#=GS A0A0D1PDA7_BRAEL/86-192   AC A0A0D1PDA7.1
#=GS A0A2S5TFG5_9GAMM/101-210  AC A0A2S5TFG5.1
#=GS A0A221W528_9PSEU/94-201   AC A0A221W528.1
#=GS A0A132PUY8_9MYCO/96-201   AC A0A132PUY8.1
#=GS A0A1V0B7Q8_9PSED/90-201   AC A0A1V0B7Q8.1
#=GS A0A0M8XBJ1_9ACTN/97-206   AC A0A0M8XBJ1.1
#=GS A0A0T7BT00_9CYAN/97-205   AC A0A0T7BT00.1
#=GS A0A1I2J272_9ACTN/92-199   AC A0A1I2J272.1
#=GS A0A1C4RB61_9ACTN/101-206  AC A0A1C4RB61.1
#=GS A0A022MJ43_9ACTN/94-202   AC A0A022MJ43.1
#=GS L8LUJ0_9CYAN/94-201       AC L8LUJ0.1
#=GS A0A0T1W5S9_9MYCO/84-201   AC A0A0T1W5S9.1
#=GS A0A147H3N0_9BURK/84-191   AC A0A147H3N0.1
#=GS A0A3B7D8N6_9ACTN/74-181   AC A0A3B7D8N6.1
#=GS G8RHV6_MYCRN/84-186       AC G8RHV6.1
#=GS A0A2N3UGJ4_9ACTN/98-205   AC A0A2N3UGJ4.1
#=GS A0A166L6U2_9GAMM/73-181   AC A0A166L6U2.1
#=GS A0A132T3R9_9MYCO/84-201   AC A0A132T3R9.1
#=GS A0A1X9YKX8_9SPHN/75-184   AC A0A1X9YKX8.1
#=GS A0A085WEV8_9DELT/95-203   AC A0A085WEV8.1
#=GS A0A2L0EI09_SORCE/94-204   AC A0A2L0EI09.1
#=GS A0A0N9HZS4_9PSEU/89-188   AC A0A0N9HZS4.1
#=GS A0A385C8U6_9GAMM/86-195   AC A0A385C8U6.1
#=GS A0A256BGB8_9CYAN/97-204   AC A0A256BGB8.1
#=GS A0A1V4ADC7_9ACTN/95-203   AC A0A1V4ADC7.1
#=GS A0A0J6VSI0_9MYCO/84-186   AC A0A0J6VSI0.1
#=GS A0A1H0S0P2_9BRAD/94-206   AC A0A1H0S0P2.1
#=GS I4BCP6_MYCCN/84-186       AC I4BCP6.1
#=GS A0A495ALE0_9ENTR/92-200   AC A0A495ALE0.1
#=GS B9JP64_AGRRK/84-192       AC B9JP64.1
#=GS A0A428YRL4_9ACTN/93-201   AC A0A428YRL4.1
#=GS A0A1B1WPH2_9MYCO/84-185   AC A0A1B1WPH2.1
#=GS A0A1M5F9X1_STRHI/88-197   AC A0A1M5F9X1.1
#=GS A0A426VC27_9BURK/124-230  AC A0A426VC27.1
#=GS A0A239EPH4_9BACT/89-196   AC A0A239EPH4.1
#=GS Q8YTB0_NOSS1/116-225      AC Q8YTB0.1
#=GS A0A0F6W5I0_9DELT/96-203   AC A0A0F6W5I0.1
#=GS A0A1C0UUU4_9CYAN/99-206   AC A0A1C0UUU4.1
#=GS A0A1H3NVJ8_9PSEU/95-203   AC A0A1H3NVJ8.1
#=GS B9TM16_RICCO/95-196       AC B9TM16.1
#=GS A0A2S9H2V1_9BURK/86-192   AC A0A2S9H2V1.1
#=GS A0A1X9YKZ4_9SPHN/112-221  AC A0A1X9YKZ4.1
#=GS A0A117QMW6_9ACTN/95-200   AC A0A117QMW6.1
#=GS A0A429Z277_9RHIZ/96-204   AC A0A429Z277.1
#=GS A0A2C8F5B8_9DELT/97-207   AC A0A2C8F5B8.1
#=GS A0A399EVB2_9DEIN/95-202   AC A0A399EVB2.1
#=GS A0A0Q2X9R8_MYCGO/95-200   AC A0A0Q2X9R8.1
#=GS I3TPU2_TISMK/95-202       AC I3TPU2.1
#=GS Q4FS29_PSYA2/126-233      AC Q4FS29.1
#=GS A0A1Y0RJH9_9CYAN/87-194   AC A0A1Y0RJH9.1
#=GS A5VEI0_SPHWW/89-196       AC A5VEI0.1
#=GS A0A1I6FU74_9RHOB/90-192   AC A0A1I6FU74.1
#=GS W3RGD1_9BRAD/86-192       AC W3RGD1.1
#=GS A0A1C4M8H3_9ACTN/94-202   AC A0A1C4M8H3.1
#=GS A0A1I3DGZ6_9BURK/93-199   AC A0A1I3DGZ6.1
#=GS Q1YTL2_9GAMM/95-202       AC Q1YTL2.1
#=GS A0A1X0DEP5_9MYCO/84-184   AC A0A1X0DEP5.1
#=GS J2LPY3_9BURK/91-199       AC J2LPY3.1
#=GS A0A1X1SXR5_9MYCO/86-187   AC A0A1X1SXR5.1
#=GS A5V7C0_SPHWW/87-196       AC A5V7C0.1
#=GS A0A2N7VIV4_9BURK/94-197   AC A0A2N7VIV4.1
#=GS A0A145WKT0_9GAMM/87-195   AC A0A145WKT0.1
#=GS A0A1V8RV80_9RHIZ/103-210  AC A0A1V8RV80.1
#=GS D7DHK9_METV0/96-201       AC D7DHK9.1
#=GS C6WK99_ACTMD/94-202       AC C6WK99.1
#=GS A0A081XJ31_STRTO/96-204   AC A0A081XJ31.1
#=GS A0A1G8H5S3_9ACTN/89-196   AC A0A1G8H5S3.1
#=GS W0RUQ1_9BACT/120-228      AC W0RUQ1.1
#=GS A0A2T4V284_9DELT/124-232  AC A0A2T4V284.1
#=GS A0A0D5LQQ1_9RHIZ/96-204   AC A0A0D5LQQ1.1
#=GS A7HS18_PARL1/94-201       AC A7HS18.1
#=GS A0A1C0BIK4_9CLOT/88-196   AC A0A1C0BIK4.1
#=GS B8HSG2_CYAP4/113-225      AC B8HSG2.1
#=GS A0A1W2AJ43_KIBAR/89-188   AC A0A1W2AJ43.1
#=GS A0A161I8B8_9BURK/115-222  AC A0A161I8B8.1
#=GS A0A3N1CYA9_9ACTN/93-201   AC A0A3N1CYA9.1
#=GS A6FYT8_9DELT/87-190       AC A6FYT8.1
#=GS K9QFH9_9NOSO/97-204       AC K9QFH9.1
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A0A286H6M1_9ACTN/113-218             ..................................................--RAALRAVIAAFVSLI..ED.E....P.ELYRFAY.....AH........T.....G.........R.......S.........G.........R.........A.....DL.......V...A...........AT......EH..R...I...A..D...A.LA.A.L.......F...A..E.............R.....M......E.....A......A....G..Q..P....S........G.....AA..AtwAYG..L.VGM..V.Q.LTSHWWAT..TRS.........VPST...ELVEQ.LVAL-----adg......................
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A0A1Q5PXQ1_9ACTO/86-192              ................................................pr--PEMIAALLVPLAEFK..RA.N....A.TFAMVYA.....HP........N.....L.........P.......A.........E.........L.........R.....QE.......V...D...........GV......NQ..A...F...T..T...R.LV.A.L.......L...A..A.............R.....N......P.....A......T....P..R..E....T........L.....EL..A..ARQ..A.ACL..F.R.GSLPLLGS..VTG.........DEQR...D-TQE.LCTVIDAYL.........................
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A0A1G8D1I0_9MICO/111-213             ................................................dd-----LTALFHAYVELY..RD.L....P.GYRSVRT.....GE........T.....-.........L.......P.........T.........S.........M.....RP.......K...G...........AV......VV..E...L...V..E...R.VA.A.A.......I...G..P.............R.....Y......G.....I......A....V..D..A....E........Y.....RE..R..FVD..C.FHV..V.D.AVVGAAFV..DDP.........RGDD...HLIA-.---------layevarav................
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