GenomeNet

Database: Pfam
Entry: TetR_C_17
LinkDB: TetR_C_17
Original site: TetR_C_17 
#=GF ID   TetR_C_17
#=GF AC   PF17922.2
#=GF DE   Tetracyclin repressor-like, C-terminal domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF00742
#=GF GA   26.10 26.10;
#=GF TC   26.10 26.10;
#=GF NC   26.00 26.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   15944459
#=GF RT   The TetR family of transcriptional repressors.
#=GF RA   Ramos JL, Martinez-Bueno M, Molina-Henares AJ, Teran W, Watanabe
#=GF RA   K, Zhang X, Gallegos MT, Brennan R, Tobes R;
#=GF RL   Microbiol Mol Biol Rev. 2005;69:326-356. 
#=GF RN   [2]
#=GF RM   16862575
#=GF RT   Crystal structure of YfiR, an unusual TetR/CamR-type putative
#=GF RT   transcriptional regulator from Bacillus subtilis.
#=GF RA   Rajan SS, Yang X, Shuvalova L, Collart F, Anderson WF;
#=GF RL   Proteins. 2006;65:255-257.
#=GF RN   [3]
#=GF RM   7707374
#=GF RT   The complex formed between Tet repressor and tetracycline-Mg2+
#=GF RT   reveals mechanism        of antibiotic resistance.
#=GF RA   Kisker C, Hinrichs W, Tovar K, Hillen W, Saenger W;
#=GF RL   J Mol Biol. 1995;247:260-280.
#=GF DR   INTERPRO; IPR041612;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   TetR family regulators are involved in the transcriptional
#=GF CC   control of multidrug efflux pumps, pathways for the biosynthesis
#=GF CC   of antibiotics, response to osmotic stress and toxic chemicals,
#=GF CC   control of catabolic pathways, differentiation processes, and
#=GF CC   pathogenicity [1]. The TetR proteins identified in overm ultiple
#=GF CC   genera of bacteria and archaea share a common helix-turn-helix
#=GF CC   (HTH) structure in their DNA-binding domain. However, TetR
#=GF CC   proteins can work in different ways: they can bind a target
#=GF CC   operator directly to exert their effect (e.g. TetR binds Tet(A)
#=GF CC   gene to repress it in the absence of tetracycline), or they can
#=GF CC   be involved in complex regulatory cascades in which the TetR
#=GF CC   protein can either be modulated by another regulator or TetR can
#=GF CC   trigger the cellular response [1]. This entry represents the
#=GF CC   C-terminal domain present in Yfir transcription regulator
#=GF CC   proteins found in Bacillus subtilus [2]. TetR regulates the
#=GF CC   expression of the membrane-associated tetracycline resistance
#=GF CC   protein, TetA, which exports the tetracycline antibiotic out of
#=GF CC   the cell before it can attach to the ribosomes and inhibit
#=GF CC   protein synthesis [3]. TetR blocks transcription from the genes
#=GF CC   encoding both TetA and TetR in the absence of antibiotic. The
#=GF CC   C-terminal domain is multi-helical and is interlocked in the
#=GF CC   homodimer with the helix-turn-helix (HTH) DNA-binding domain
#=GF CC   [3].
#=GF SQ   230
#=GS A0A1D9P388_9FIRM/84-181   AC A0A1D9P388.1
#=GS A0A430JK60_9BACL/109-181  AC A0A430JK60.1
#=GS A0A373VG70_9FIRM/83-171   AC A0A373VG70.1
#=GS A0A1Z4R9C8_9CYAN/82-181   AC A0A1Z4R9C8.1
#=GS R9K9T8_9FIRM/83-178       AC R9K9T8.1
#=GS A0A3G3JVY5_9BACL/109-181  AC A0A3G3JVY5.1
#=GS A0A285RYD8_9BACI/86-185   AC A0A285RYD8.1
#=GS A0A1X7H844_9BACL/103-182  AC A0A1X7H844.1
#=GS A0A0Q7J3R7_9BACL/104-182  AC A0A0Q7J3R7.1
#=GS A0A0C2XXT3_BACBA/86-187   AC A0A0C2XXT3.1
#=GS A0A2V3W8R1_9BACI/86-183   AC A0A2V3W8R1.1
#=GS G8QX46_SPHPG/83-178       AC G8QX46.1
#=GS A0A3A8WM28_9BACT/109-202  AC A0A3A8WM28.1
#=GS R5C0H4_9FIRM/83-177       AC R5C0H4.1
#=GS A0A0A2TFN5_9BACI/97-188   AC A0A0A2TFN5.1
#=GS A0A429X7G0_9BACI/86-187   AC A0A429X7G0.1
#=GS A0A0U1NRS8_9BACI/89-187   AC A0A0U1NRS8.1
#=GS D3E5L5_GEOS4/86-186       AC D3E5L5.1
#=GS A0A0Q5M9D7_9MICO/85-175   AC A0A0Q5M9D7.1
#=GS A0A401HWP3_9BACL/84-180   AC A0A401HWP3.1
#=GS A0A037Z469_CLOTT/86-187   AC A0A037Z469.1
#=GS A0A229URJ0_9BACL/107-181  AC A0A229URJ0.1
#=GS A0A1M7QGL4_9BACI/117-183  AC A0A1M7QGL4.1
#=GS A0A1I6BSK0_9BACI/88-187   AC A0A1I6BSK0.1
#=GS A0A1H7XTU8_9BACT/108-183  AC A0A1H7XTU8.1
#=GS A0A417PE87_9CLOT/83-173   AC A0A417PE87.1
#=GS R7N4W8_9FIRM/80-177       AC R7N4W8.1
#=GS A0A1I1IWS6_9FIRM/84-181   AC A0A1I1IWS6.1
#=GS A0A417VT98_9FIRM/83-172   AC A0A417VT98.1
#=GS A0A3N9UI39_9BACI/86-185   AC A0A3N9UI39.1
#=GS R9JR76_9FIRM/83-180       AC R9JR76.1
#=GS Q4KCK0_PSEF5/101-182      AC Q4KCK0.1
#=GS A0A3A9ESK3_9BACT/83-178   AC A0A3A9ESK3.1
#=GS A0A3L7JR40_9BACI/90-183   AC A0A3L7JR40.1
#=GS A0A239IBI3_9FIRM/83-177   AC A0A239IBI3.1
#=GS R6QP33_9FIRM/108-201      AC R6QP33.1
#=GS N2A285_9FIRM/83-177       AC N2A285.1
#=GS A0A3A9CY24_9BACT/83-180   AC A0A3A9CY24.1
#=GS A0A0M4LAK4_9MICC/88-183   AC A0A0M4LAK4.1
#=GS R9MYU5_9FIRM/83-180       AC R9MYU5.1
#=GS R6ZHB8_9FIRM/83-180       AC R6ZHB8.1
#=GS A0A1H8XRT5_9SPHI/112-184  AC A0A1H8XRT5.1
#=GS A0A1B1YZJ3_9BACI/88-188   AC A0A1B1YZJ3.1
#=GS A0A1H0XWG9_9BACI/99-187   AC A0A1H0XWG9.1
#=GS V6M697_9BACL/86-185       AC V6M697.1
#=GS A0A3Q9BK31_9LACT/86-185   AC A0A3Q9BK31.1
#=GS W1SR32_9BACI/89-190       AC W1SR32.1
#=GS A0A1G6HLE0_9LACT/88-188   AC A0A1G6HLE0.1
#=GS B1CC44_9FIRM/80-176       AC B1CC44.1
#=GS S2KRI3_9FIRM/83-180       AC S2KRI3.1
#=GS A0A075R0H2_BRELA/86-187   AC A0A075R0H2.1
#=GS A0A370GIL6_9BACI/88-186   AC A0A370GIL6.1
#=GS A0A2V5KBX3_9BACL/79-179   AC A0A2V5KBX3.1
#=GS H3SGS0_9BACL/105-182      AC H3SGS0.1
#=GS A0A1K1R3Z2_9BACT/124-182  AC A0A1K1R3Z2.1
#=GS A0A3G9IXN7_9BACL/106-180  AC A0A3G9IXN7.1
#=GS A0A1H3XUR6_9FIRM/83-177   AC A0A1H3XUR6.1
#=GS A0A0M0X8M0_9BACI/80-178   AC A0A0M0X8M0.1
#=GS A0A0F5R0J0_9BACL/91-187   AC A0A0F5R0J0.1
#=GS A0A2V3VYX6_9BACI/86-185   AC A0A2V3VYX6.1
#=GS A0A0C1R2M3_9CLOT/86-181   AC A0A0C1R2M3.1
#=GS A0A2W1LC98_9BACL/105-182  AC A0A2W1LC98.1
#=GS A0A369BDB1_9BACL/85-184   AC A0A369BDB1.1
#=GS A0A1H7QLR6_9FIRM/84-181   AC A0A1H7QLR6.1
#=GS K0AXQ3_CLOA9/86-177       AC K0AXQ3.1
#=GS A0A1G8RU15_9BACI/108-182  AC A0A1G8RU15.1
#=GS A0A3A9A452_9BACT/83-178   AC A0A3A9A452.1
#=GS I8UFF6_9BACI/98-187       AC I8UFF6.1
#=GS A0A3M8DN46_9BACL/114-180  AC A0A3M8DN46.1
#=GS A0A1G7EKM1_9BACL/83-180   AC A0A1G7EKM1.1
#=GS A0A265Q6B4_9FIRM/86-187   AC A0A265Q6B4.1
#=GS A0A2H5XMQ8_9BACT/93-187   AC A0A2H5XMQ8.1
#=GS A0A417U6X2_9FIRM/83-180   AC A0A417U6X2.1
#=GS G8PA84_PEDCP/88-186       AC G8PA84.1
#=GS A0A3B0BZ12_9BACL/112-182  AC A0A3B0BZ12.1
#=GS A0A1I5GZ60_9FIRM/86-183   AC A0A1I5GZ60.1
#=GS A0A1C1A5P7_9BACL/106-179  AC A0A1C1A5P7.1
#=GS A0A1S2R8K4_9BACI/96-188   AC A0A1S2R8K4.1
#=GS A0A0Q3WBD0_9BACI/91-188   AC A0A0Q3WBD0.1
#=GS A0A0A8X4Q1_9BACI/92-189   AC A0A0A8X4Q1.1
#=GS A0A1I5RRH1_9FIRM/84-181   AC A0A1I5RRH1.1
#=GS A0A1E5LG53_9BACI/100-188  AC A0A1E5LG53.1
#=GS A0A1I7K3W8_9FIRM/84-181   AC A0A1I7K3W8.1
#=GS A0A0R2B718_LACCL/88-186   AC A0A0R2B718.1
#=GS A9B5Y1_HERA2/82-194       AC A9B5Y1.1
#=GS H6NIV2_9BACL/105-181      AC H6NIV2.1
#=GS E0S1A0_BUTPB/89-188       AC E0S1A0.1
#=GS A0A1C7I9K2_9FIRM/83-177   AC A0A1C7I9K2.1
#=GS A0A3S3ZMF9_9BACI/97-188   AC A0A3S3ZMF9.1
#=GS E3GL92_9FIRM/84-173       AC E3GL92.1
#=GS A0A1X7JNQ4_9BACL/85-186   AC A0A1X7JNQ4.1
#=GS C0D9U7_9FIRM/83-177       AC C0D9U7.1
#=GS A0A0Q3TA52_9BACI/91-187   AC A0A0Q3TA52.1
#=GS W1SG42_9BACI/85-184       AC W1SG42.1
#=GS K6CI36_9BACI/96-190       AC K6CI36.1
#=GS A0A2Y9BE56_9FIRM/83-177   AC A0A2Y9BE56.1
#=GS A0A1V4HNM2_9BACL/104-183  AC A0A1V4HNM2.1
#=GS A0A3A1R0V8_9BACI/91-188   AC A0A3A1R0V8.1
#=GS A0A401UID7_9CLOT/83-186   AC A0A401UID7.1
#=GS S0K2J5_9ENTE/88-186       AC S0K2J5.1
#=GS A0A081P1Y3_9BACL/112-182  AC A0A081P1Y3.1
#=GS A0A1H0EHA2_9RHIZ/122-193  AC A0A1H0EHA2.1
#=GS R9JBL3_9FIRM/83-180       AC R9JBL3.1
#=GS A0A385NPC9_9BACI/89-187   AC A0A385NPC9.1
#=GS E0IFV7_9BACL/120-183      AC E0IFV7.1
#=GS A0A430B6U6_9ENTE/87-187   AC A0A430B6U6.1
#=GS A5HZG4_CLOBH/86-187       AC A5HZG4.1
#=GS A0A0A1MBX9_9BACI/85-184   AC A0A0A1MBX9.1
#=GS A0A2K4ZJB4_9FIRM/83-180   AC A0A2K4ZJB4.1
#=GS A8MG79_ALKOO/86-187       AC A8MG79.1
#=GS A0A059NXE5_9BACI/101-187  AC A0A059NXE5.1
#=GS A0A3G3K6I3_9BACL/147-246  AC A0A3G3K6I3.1
#=GS A0A265Q4V1_9FIRM/127-225  AC A0A265Q4V1.1
#=GS I4D6T6_DESAJ/83-178       AC I4D6T6.1
#=GS A0A0P6WDX2_9BACI/90-188   AC A0A0P6WDX2.1
#=GS R6CDX1_9CLOT/83-180       AC R6CDX1.1
#=GS A0A1G7KQG6_9SPHI/113-184  AC A0A1G7KQG6.1
#=GS A0A143XVJ9_9FIRM/83-177   AC A0A143XVJ9.1
#=GS A0A0R2FWU6_9LACO/88-187   AC A0A0R2FWU6.1
#=GS A0A2I0CRX2_9PSED/111-181  AC A0A2I0CRX2.1
#=GS A0A3A9GPA3_9FIRM/83-179   AC A0A3A9GPA3.1
#=GS A0A0D1W3Z6_ANEMI/86-187   AC A0A0D1W3Z6.1
#=GS A0A2V5K8L1_9BACL/91-190   AC A0A2V5K8L1.1
#=GS F5LH15_9BACL/83-184       AC F5LH15.1
#=GS A0A0R1VYQ8_9LACO/92-194   AC A0A0R1VYQ8.1
#=GS A0A1H9G1P7_9FIRM/97-194   AC A0A1H9G1P7.1
#=GS A0A1N6YMW7_9BACT/115-188  AC A0A1N6YMW7.1
#=GS A0A2S5TSX2_9RHIZ/119-212  AC A0A2S5TSX2.1
#=GS A0A0A5GE56_9BACI/87-186   AC A0A0A5GE56.1
#=GS A0A371AUN1_9FIRM/101-193  AC A0A371AUN1.1
#=GS M8DBB2_9BACL/86-187       AC M8DBB2.1
#=GS A0A3S1DKG4_9BACL/82-180   AC A0A3S1DKG4.1
#=GS G8LZZ5_CLOCD/87-187       AC G8LZZ5.1
#=GS I8AN16_9BACI/96-187       AC I8AN16.1
#=GS U2EHX6_9FIRM/87-182       AC U2EHX6.1
#=GS G2TPV5_BACCO/88-184       AC G2TPV5.1
#=GS A0A1R3TKQ2_9RHIZ/91-196   AC A0A1R3TKQ2.1
#=GS A0A1G5XP32_9FIRM/83-180   AC A0A1G5XP32.1
#=GS A0A1T5M8N6_9CLOT/86-182   AC A0A1T5M8N6.1
#=GS A0A235F516_9BACI/88-187   AC A0A235F516.1
#=GS A0A3A8ZKA3_9BACT/83-180   AC A0A3A8ZKA3.1
#=GS I0JTB1_HALH3/102-188      AC I0JTB1.1
#=GS A0A398CKI4_9BACL/120-183  AC A0A398CKI4.1
#=GS A0A3A8Y5A8_9BACT/83-179   AC A0A3A8Y5A8.1
#=GS A0A3S9UZS2_9BACL/86-187   AC A0A3S9UZS2.1
#=GS A0A2Y9BJW2_9FIRM/83-179   AC A0A2Y9BJW2.1
#=GS A0A0Q5UX48_9FLAO/109-182  AC A0A0Q5UX48.1
#=GS A0A037Z5V2_CLOTT/90-189   AC A0A037Z5V2.1
#=GS A0A3L7JZ83_9BACI/111-205  AC A0A3L7JZ83.1
#=GS V6J017_9BACL/86-183       AC V6J017.1
#=GS C6CYI0_PAESJ/91-191       AC C6CYI0.1
#=GS A0A1A5YMR8_9BACL/99-198   AC A0A1A5YMR8.1
#=GS A0A168Q2Y5_9BACL/107-182  AC A0A168Q2Y5.1
#=GS A0A1X7HN65_9BACL/87-188   AC A0A1X7HN65.1
#=GS A0A2P8HDA5_9BACT/120-193  AC A0A2P8HDA5.1
#=GS A1BFU6_CHLPD/110-185      AC A1BFU6.1
#=GS A0A0C2QLT3_9BACL/105-182  AC A0A0C2QLT3.1
#=GS A0A0V8IRQ9_9BACI/96-186   AC A0A0V8IRQ9.1
#=GS A0A3A9FMK2_9BACT/83-179   AC A0A3A9FMK2.1
#=GS R9GUW9_9SPHI/110-185      AC R9GUW9.1
#=GS A0A0A8X897_9BACI/99-188   AC A0A0A8X897.1
#=GS A0A3Q9I766_9BACL/85-184   AC A0A3Q9I766.1
#=GS A0A2Z2KR59_9BACL/83-180   AC A0A2Z2KR59.1
#=GS A0A1H8IZS7_9BACI/97-188   AC A0A1H8IZS7.1
#=GS A0A3P1V4R2_9ACTO/67-160   AC A0A3P1V4R2.1
#=GS A0A1V4IWE2_9CLOT/90-189   AC A0A1V4IWE2.1
#=GS A0A1C0ZT58_9BACL/105-182  AC A0A1C0ZT58.1
#=GS A0A3A9B1H1_9BACT/83-180   AC A0A3A9B1H1.1
#=GS A0A2N5M8Z4_9BACI/90-205   AC A0A2N5M8Z4.1
#=GS A0A2D1SXY9_9BACL/504-604  AC A0A2D1SXY9.1
#=GS K6DT59_9BACI/88-187       AC K6DT59.1
#=GS A0A1X7GXG4_9BACL/83-180   AC A0A1X7GXG4.1
#=GS A0A2T4VTJ2_9DELT/110-181  AC A0A2T4VTJ2.1
#=GS A0A1M4WB52_9CLOT/83-173   AC A0A1M4WB52.1
#=GS A0A231R6M3_9BACL/85-184   AC A0A231R6M3.1
#=GS T0MXM1_9CLOT/86-185       AC T0MXM1.1
#=GS A0A3A9F116_9BACT/82-176   AC A0A3A9F116.1
#=GS A0A0M0WBJ8_9BACI/100-188  AC A0A0M0WBJ8.1
#=GS I4AG32_BERLS/107-183      AC I4AG32.1
#=GS C0Z4K7_BREBN/86-187       AC C0Z4K7.1
#=GS A0A1S2R458_9BACI/97-188   AC A0A1S2R458.1
#=GS A0A1Y4F097_9FIRM/83-186   AC A0A1Y4F097.1
#=GS A0A0J1F610_9FIRM/83-178   AC A0A0J1F610.1
#=GS A0A0Q3WY30_9BACI/93-188   AC A0A0Q3WY30.1
#=GS A0A081P5G1_9BACL/86-187   AC A0A081P5G1.1
#=GS A0A1G4VF23_9FIRM/78-176   AC A0A1G4VF23.1
#=GS A0A3D9IUF9_9BACL/105-179  AC A0A3D9IUF9.1
#=GS A0A1I7G8U0_9FIRM/84-181   AC A0A1I7G8U0.1
#=GS A0A1G5HQA8_9FIRM/84-182   AC A0A1G5HQA8.1
#=GS A0A1I0CU66_9BACL/88-187   AC A0A1I0CU66.1
#=GS A0A0J6D1C7_9BACI/94-187   AC A0A0J6D1C7.1
#=GS A0A1I7KVY2_9BACL/88-187   AC A0A1I7KVY2.1
#=GS A6CHJ4_9BACI/91-188       AC A6CHJ4.1
#=GS A0A1I6BTF7_9BACI/95-189   AC A0A1I6BTF7.1
#=GS A0A0Q3SAZ6_9BACI/99-188   AC A0A0Q3SAZ6.1
#=GS A0A3S1JQD6_9BACL/129-228  AC A0A3S1JQD6.1
#=GS A0A024QGS0_9BACI/83-184   AC A0A024QGS0.1
#=GS W1I2K5_KLEPN/6-72         AC W1I2K5.1
#=GS U5L516_9BACI/100-189      AC U5L516.1
#=GS A0A084GK41_BACID/88-186   AC A0A084GK41.1
#=GS A0A370G2B2_9BACI/91-188   AC A0A370G2B2.1
#=GS A0A0R1MAA2_9LACO/88-188   AC A0A0R1MAA2.1
#=GS A0A3A8Y8R5_9BACT/83-179   AC A0A3A8Y8R5.1
#=GS A0A0E4HAH3_9BACL/110-181  AC A0A0E4HAH3.1
#=GS A0A1C3RGR6_9RHIZ/116-183  AC A0A1C3RGR6.1
#=GS A0A235FBX5_9BACI/88-184   AC A0A235FBX5.1
#=GS A0A2D2MDE2_9PSED/111-181  AC A0A2D2MDE2.1
#=GS A0A0B0D3F8_9BACI/97-188   AC A0A0B0D3F8.1
#=GS R2TCT2_9ENTE/88-186       AC R2TCT2.1
#=GS A0A0K8PAT3_9CHLR/83-177   AC A0A0K8PAT3.1
#=GS A0A3A9C7C0_9BACT/83-180   AC A0A3A9C7C0.1
#=GS A0A0M2VWB6_9BACL/1-91     AC A0A0M2VWB6.1
#=GS I3EAW1_BACMM/88-187       AC I3EAW1.1
#=GS A0A242L6T5_9ENTE/86-185   AC A0A242L6T5.1
#=GS R6EE48_9FIRM/83-180       AC R6EE48.1
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A0A3N9UI39_9BACI/86-185              ...............................................i-IRDFLESYYD.I.FP...TIEDSIYPAIYEFW..IS..G..WR..EP..R.....AKA...F...FIN.R....Y....E....K.....I....R....E....L....L.S.NL....IQEGIEQGEFQ..P..TIP..AEDISKIMMSTVDG.ILIH.SLAFGAQTI---dan......................
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R6ZHB8_9FIRM/83-180                  ............................................ilal----LLKEQKK.E.LL...GKEASLTKAIYEYY..FA..N..QI..T-..G.....KDN...L...LRK.Q....F....D....Q.....A....V....H....V....L.E.KL....IDAGCQSGEFY..C..EDP..RG-AARNIMYVLEG.LKIA.ACTRGVSE----amvd.....................
A0A1H8XRT5_9SPHI/112-184             ...........................tavdaddtnpllkdkaaqavl-----------.-.--...--------------..--..-..--..--..-.....---...-...---.-....-....-....R.....W....K....K....S....I.E.NL....IQAGIDAGEFK..P..DAD..LSGTALSMIALIEGgIMIA.K-----------vtntptsl.................
A0A1B1YZJ3_9BACI/88-188              .......................................klanlfkrf--------KKQ.E.LK...EDDQQTMRVYIEFW..LF..G..SR..QE..D.....LRK...I...LAE.R....Y....N....R.....F....I....D....Y....I.V.NI....IVEGQQSGEIK..K..EID..PQNISRIFWAIRDG.NVLH.YSFLGEEE----qyri.....................
A0A1H0XWG9_9BACI/99-187              ..........................................tpdakm-----------.-.--...---DPLAPSKLEFF..IT..G..RN..DE..R.....RRE...Y...GKK.R....Y....N....L.....G....V....R....L....Y.A.DV....IKAGQDSGEFS..D..RFD..SELLSRSIITFIDG.LALD.DAILAESDVQ--le.......................
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A0A1G6HLE0_9LACT/88-188              ..............................................if--KNYLAEQKK.R.LLnydNNDDSLLRAMYEYS..FT..H..HA..DR..D.....K-K...L...KQK.Q....M....N....A.....T....K....A....T....V.R.SL....LALGVKQGVLS..G..-QN..IKVIADNFMLLIEG.MNIM.ALTGELKAQ---qid......................
B1CC44_9FIRM/80-176                  ...............................................i-IKYFLEEVKK.E.LL...NKNNNLIVATYEYI..FY..K..FN..NK..E.....NLN...-...LSK.K....Y....S....I.....A....Y....E....T....L.Y.KI....IQNGIKNKEFK..V..--E..INKTINHIIFLLEG.LRIS.SLVI--------plnekiid.................
S2KRI3_9FIRM/83-180                  ...............................................i-LLVFLKEQKK.E.IL...LKKNSITVAAYEYF..FA..N..KP..A-..K.....KDN...L...LRR.K....F....L....E.....S....V....D....I....L.K.GL....IEAGVENGEFV..C..EDP..EST-AQDIMFVLEG.LRVC.SQTMGLSESRV-d........................
A0A075R0H2_BRELA/86-187              ................................................QITKWVNRQQQ.E.MQ...RLDQSLLLANSEFF..LS..T.nYR.kNR..D.....SYP...Y...VTA.R....Y....Q....R.....L....T....E....V....I.I.AF....FRKGIEQGDIC..P..RIP..VESISLYLISFMDG.LMLD.TAHLGPEKTKVK.........................
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A0A2V5KBX3_9BACL/79-179              ...............................................q-VVKFVKLAEH.Q.IE..iVNEKSLLPALMEFN..MT..S..WR..QK..K.....NQD...F...IQW.R....Y....D....V.....G....T....E....E....M.I.QF....FKKGIDSGEFR..P..KQP..IEAIVGFFGSQVNG.LAIA.VQWAGKEKI---dyk......................
H3SGS0_9BACL/105-182                 ...........................flntaiesdhsfpilrdqale-----------.-.--...--------------..--..-..--..--..-.....---...-...---.A....Y....G....Q.....M....L....S....F....I.Q.GI....LQQGIADGEFQ..P..DMD..TEAAASFIFSSIEGgIMAS.RLTR--------dnrhvhh..................
A0A1K1R3Z2_9BACT/124-182             ...........................................aeaig-----------.-.--...--------------..--..-..--..--..-.....---...-...---.-....-....-....N.....W....K....N....K....I.A.GI....LNKGIEAGEFK..P..GLD..VEQTALTFIATIEG.AIMI.TKATG-------klnyrta..................
A0A3G9IXN7_9BACL/106-180             .........................................fltiyvq-----------.-.--...--------------..-T..S..HE..SD..S.....VRE...V...IGR.F....F....Q....N.....Q....I....I....T....L.E.NL....LQEGIAKKEFN..A..HLP..VSQIAALIVSTIEGgLFLQ.HT----------iedstl...................
A0A1H3XUR6_9FIRM/83-177              ...............................................i-LQLFLEEQKK.E.LL...AEDDTLSVATYEYG..FL..K..--..--..K.....DES...F...LRA.K....F....N....E.....A....T....R....V....I.E.YL....IRLGCHQKKFH..C..RNA..H-KMAVNVMFLIEG.LKIS.ART---------irvtgeevd................
A0A0M0X8M0_9BACI/80-178              ............................mkfvdqlntliykevvdllr-----------.-.--...--QPSLVQARAEYF..FS..L..--..--..E.....DTT...F...FEQ.R....H....K....R.....V....I....E....G....I.T.NF....LQQGVESGEFA..P..QKD..VRSIAHFMLSFVDG.LMLN.TSQLGET-----snfv.....................
A0A0F5R0J0_9BACL/91-187              .....................................asysmrlnewa-----------.-.-S...SSDRGLMPAFYEYF..LV..G..WR..DE..A.....RRE...L...LRR.R....Y....E....K.....G....I....V....Q....F.A.EL....LQTGIDRGEFN..P..VLG..VLDISRLAASFQEG.IVTH.TYAVGAAKA---ns.......................
A0A2V3VYX6_9BACI/86-185              .........................................eklryii-------KFQK.N.LEf.tEEEQKFIILQIETN..MY..L..LR..KG..D.....SEQ...V...MIE.R....L....G....R.....I....S....T....F....L.E.EI....LNEGISNGEFK..K..EIN..ATVFSKMFWSIQDG.LLVR.TAS---------kelanhh..................
A0A0C1R2M3_9CLOT/86-181              ................................................QLKDWIQKTVL.S.IQ...NSETNLVRAKSEFF..LS..H..--..DV..S.....EIP...Y...LRE.R....H....E....K.....L....A....N....A....I.Q.LF....INMGIETGEFR..D..KTD..VNSFSELLIAMIDG.IMLQ.QY----------nqfcpsik.................
A0A2W1LC98_9BACL/105-182             ............................fvtlytqaaqeavmirakig-----------.-.--...--------------..--..-..--..--..-.....---...-...--D.F....F....Q....S.....Q....M....T....L....V.E.KL....LQEGVNKRELD..P..QLP..VKEAAAMIIATIEGgLFLQ.HTDQDND-----vvsq.....................
A0A369BDB1_9BACL/85-184              .............................................afv---QFIRGQEK.R.VR...EANAGLAPCLYEYF..IV..G..RR..ED..H.....RRK...L...IEE.R....S....Q....A.....V....Y....G....T....L.F.DL....IHNGVQRGEFH..P..AQP..LDIFVHWLISLLEG.LYIE.SIINGFENIQ--la.......................
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A0A370G2B2_9BACI/91-188              ..................................latflgdkklpndk-----------.-.--...--MDPLAPSKLEYF..IT..G..RN..EK..R.....RQD...H...AKK.R....F....Q....K.....G....Y....M....I....T.Q.RI....IEEGVKAGEFT..P..KFD..PGVIAKSIISHIDG.MAID.HAILGSETIQL-k........................
A0A0R1MAA2_9LACO/88-188              ...............................................v-LDKYLELQKE.R.LL...NISKSLLMSGYEYY..SE..-..-N..SE..E.....ATQ...F...LGK.N....L....D....E.....M....R....R....T....I.L.GV....LNLGVEQKKIH..-..QED..LPTIGDHFILTIEG.LSV-.------------fcylhqasekyideqla........
A0A3A8Y8R5_9BACT/83-179              ..............................................il--DEILNKYEN.E.ML...DSQSSLSIAIYEYF..SI..R.dIA..NQ..S.....N--...T...LYE.Q....Y....L....I.....S....A....N....T....W.K.KL....LQYGMDRHEFN..-..EVD..ISAVFDLVVFSYQG.VRMY.SKLMPM------dketp....................
A0A0E4HAH3_9BACL/110-181             ...........................................vgmds-----------.-.--...--------------..--..-..-P..DE..Q.....LNA...L...IRE.R....F....D....E.....L....E....K....S....F.Y.EL....LRKGQKTGEIM..P..EKD..IKTLSYLLSNLNHS.INIV.S-----------kvqgdrskmq...............
A0A1C3RGR6_9RHIZ/116-183             ....................................hdavikaqvqdn-----------.-.--...--------------..--..-..--..--..-.....---...-...---.-....L....V....E.....I....A....E....T....F.C.GV....IEEGIANGEFK..T..TEP..AENIARFLTSTVQG.LRVM.AKSSTT------ketltt...................
A0A235FBX5_9BACI/88-184              ......................................ikmivldfkn-----------.-.AE...HSDNQFAAAQVEFN..IL..S..RN..SS..N.....AKE...F...LQR.R....Y....Q....W.....A....S....D....F....L.C.SL....INEGIKRGEFS..P..NAP..VHHIARYYITFFDG.LSIE.SIFLKSQE----lns......................
A0A2D2MDE2_9PSED/111-181             ....................................fgelqraestpa-----------.-.--...--------------..--..-..--..--..-.....-KR...M...VQT.L....I....Q....R.....Y....G....E....R....L.H.RL....IEKGKTSGELS..P..SLD..NEAAATLFIGTIQG.LVMQ.SLLA--------gdvg.....................
A0A0B0D3F8_9BACI/97-188              .......................................engepddem-----------.-.--...---DPMAPSNLEFF..IT..G..RN..DH..R.....RRE...Y...GQK.R....Y....K....L.....G....L....K....L....Y.A.NV....IEAGQRSGEFS..Q..KYD..SGLIARSIISYIDG.LSLD.GAILPKEEIQ--lk.......................
R2TCT2_9ENTE/88-186                  ..............................................ll--DTYFNSHKE.R.LL..nSINDSILRAMYEYY..FT..H..KS..EE..D.....-RE...F...QQA.Q....M....A....A.....T....K....Q....T....I.Y.EI....LELGVQQGVLT..-..DQP..LDTLAENFMFVIEG.LSVL.ALIGDITE----aqid.....................
A0A0K8PAT3_9CHLR/83-177              .............................................lfq---FFIEQQKS.A.IL...NHKGKFNVAVYEFF..Q-..-..-T..EP..E.....MME...L...MND.R....F....S....A.....A....V....R....M....L.K.TL....IEYGNRDYGFS..-..VQN..TQETARFAVLYLEG.IINA.SAL---------mpmsekml.................
A0A3A9C7C0_9BACT/83-180              ..............................................il--RFFLKEQKK.E.IL...SQTNTLTVATYEFF..FA..N..KV..S-..K.....KEN...I...IKH.T....F....E....T.....A....V....K....V....L.A.DL....LLAGTESEELY..C..ENP..VGT-ARNIMLVLEG.MKVA.SHTMGV------sekfvd...................
A0A0M2VWB6_9BACL/1-91                ...............................................m---NFFEKQKT.E.MV...NMQGSIRIAVYEYF..LS..Q..K-..ND..L.....AAD...L...LKD.Y....F....N....G.....A....V....A....L....V.S.QT....LAYGIDRGEIV..P..L-D..TEQTARHIVLVLEG.LNTL.A-----------mgtsvp...................
I3EAW1_BACMM/88-187                  ...............................................g-VLQFLESQEQ.E.IM...EVDESLIPVILEYY..MI..D..LR..EK..T.....KDA...F...LFN.R....Y....Q....K.....A....V....K....V....V.E.LL....FQKGVVHGEFK..P..VIP..ISEVARFVVAFLDG.LIME.AIYLGTEEVKIK.........................
A0A242L6T5_9ENTE/86-185              ...............................................r-LEEWLRDVFK.E.IN...EPNKNLVRARSEFF..LR..F..SA..--..E.....EVP...Y...ISD.R....R....R....E.....L....Q....D....V....L.V.TF....LEEGIKKKELN..K..TLN..SVIFADLLISMVDG.LMLS.EAK---------nhsskeilqkk..............
R6EE48_9FIRM/83-180                  .............................................ill---LFLKEQKK.E.LL...RKKNTLTQATYEFY..FE..N..-D..LP..K.....RDN...I...LKK.Q....F....D....S.....A....V....K....I....I.E.KL....IEAGVDNGEFL..C..EDC..-EGTARNIMFVLEG.LKIS.AQTIGVTAE---avd......................
A0A209DD48_9BACL/88-187              ...............................................v-IQQIYDRQLH.D.LE...NYGGGIVPAFYEYF..LV..G..WR..DA..P.....RSE...L...LHQ.R....Y....E....K.....G....I....K....L....F.E.QL....LQAGVERGEFT..P..SLP..LSDIAKLISSFQEG.IVTH.AITIGLEKANT-h........................
A0A1B1Z7A7_9BACI/88-185              ....................................lvkdfedyksad-----------.-.--...DTEDLFGAVQIEYF..LI..N..RL..LP..E.....KKI...Y...MKE.R....Y....E....F.....A....I....E....H....L.M.NL....FDEGVKKGEFN..P..KYP..LDTIARYFITFNDG.INIA.TIFLNKKD----lnfn.....................
A0A1M6K4Z2_9FIRM/83-179              ...............................................i-LNQLLEKYRL.E.ML...DARNSLSLAICEYF..-S..K..KR..IE..E.....NDN...L...LSQ.Q....Y....Q....M.....S....F....S....S....W.D.RL....IQYGILRGDFR..-..QVD..SRTIFDLILFSYQG.VRMY.SLLM--------nisedip..................
F7KGR0_9FIRM/83-177                  ...............................................l-LKDYLLSELG.E.VQ...DRKPGLCGAIYEYC..LE..N..-R..ET..Q.....SPS...F...MSA.Q....Y....E....R.....G....K....E....L....L.L.KL....LAYGIRTGEFH..L..EEP..GEAAS-AVLFMVEG.VK--.------------mcsevmpitee..............
A0A3A9STN6_9FIRM/84-181              ..............................................ml--ALFLKEQKK.E.IL...RKKNNLTVATYEYF..TL..H..KA..A-..V.....SDN...P...LKR.Q....F....D....T.....A....V....R....I....V.E.KL....IETGAQSGEFY..C..ENP..LG-CARNLMYVVEG.LKIT.AGTIGVTE----eaid.....................
A0A0M2VPG1_9BACL/86-186              ...............................................r-LTRWVDVQRK.S.IE...GINDSLVRAKAEFF..LT..S.kYV..RQ..H.....HVP...F...LEQ.R....Y....N....N.....L....K....D....T....I.K.GF....IEKGVERGEFR..P..RLP..ADHISLYFISFIDG.LMLN.TFQLKTETTNV-d........................
A0A385NJK0_9BACI/106-181             ...........................................lntai-----------.-.--...--------------..--..-..-E..SD..D.....GHP...L...LKE.R....S....Q....Q.....A....M....KflidR....L.S.MI....IVEGIENKEFR..S..DIN..PDEVSSYFIAVIEGgLMLS.KLFDD-------skyir....................
A0A285TP75_9BACI/6-115               inkvnqnliiinsisewrkiesfldeqkkfffelieensncsayiids-----------.-.--...--------------..--..-..--..--..-.....--K...T...LQT.R....Y....E....I.....N....S....N....S....L.K.NY....IETGIETGEFA..P..QYP..VSTCVEMLITTLEG.LHFN.SRFI--------yshqkivs.................
A0A1H0WNY6_9BACI/87-186              ...............................................g-LDTYLNEVEK.A.LI...NSSTSFASVNLEYF..II..G..RH..AE..G.....RRD...F...ISE.R....Y....K....Q.....A....I....G....H....F.T.KL....LGKGVEQGEFK..P..IQP..VDAIANYLINIVDS.MHIQ.LLVIDKEQSYI-s........................
A0A178A2Z2_9BACI/86-187              ................................................QLKNWVEEQRL.Y.IE...RIDQTLLYARAEFF..LS..S.nYA.nDK..D.....NFP...Y...ISE.R....Y....N....R.....I....I....E....A....I.E.EV....LNEGKRKGEFR..P..QQS..TRSIARYLISFIDG.LMLD.TFQLGDEQTKVK.........................
A0A0L0W839_CLOPU/86-185              .............................................kli---NYIHWTLT.GlFE...EKIQKMSRFTFEFW..SV..L..AR..NP..N.....MSD...K...AKE.R....Y....K....L.....F....Y....D....D....L.A.EI....LQQGIDCGEFE..K..DID..ISSMVYIILSTMDG.IGYM.NSV---------mkitithd.................
A0A3A9A846_9BACT/83-180              ...............................................i-LTLFLKEQKK.E.LL...QNKDNLTVAVYEYF..FA..H..K-..ST..D.....KNN...M...LRK.Q....F....D....A.....G....V....R....V....I.E.KL....IEAGIASGEFY..C..ENP..KGAAANI-MYVLEG.LKIN.AQTFGITEK---mvd......................
C0Z945_BREBN/111-182                 ......................................esdhsfpvlr-----------.-.--...--------------..--..-..--..--..-.....--D...Y...AVA.A....Y....Q....E.....T....I....S....F....M.Q.GL....LEEGISQGEFR..S..EMD..AEAVASVIFSSIEG.AIMA.SR----------lthdnkhvhf...............
A0A0L0WC38_CLOPU/86-187              ................................................QLTNWVESQQR.N.IE...TINESLLICKTEFF..LT..T..YYlgNR..G.....NHS...Y...VTE.R....Y....Q....K.....L....V....N....S....I.K.KF....IQKGSERGEFQ..P..RLS..SESIALYLISFLDG.LMLD.TFHLGIERTKV-n........................
YFIR_BACSU/87-186                    ...............................................s-ISSYLDELTE.G.LR...DVADTLAPVQFEYL..VT..A..WR..NE..E.....RRQ...Y...LEK.R....Y....D....L.....F....V....E....R....F.S.RL....LQKGIDQGEFQ..P..VQP..LATIAKFFLNMNDG.IIQN.ALYFDEEKADVS.........................
#=GR YFIR_BACSU/87-186         SS    ...............................................H-HHHHHHCHHH.H.TT...TGGGSSHHHHHHHH..HG..G..GG..-H..H.....HHH...H...HHH.H....H....H....H.....H....H....H....H....H.H.HH....HHHHHHTTS--..-..SS-..HHHHHHHHHHHHHH.HHHH.HHHS-HHHH-HH.........................
#=GC SS_cons                         ...............................................H-HHHHHHCHHH.H.TT...TGGGSSHHHHHHHH..HG..G..GG..-H..H.....HHH...H...HHH.H....H....H....H.....H....H....H....H....H.H.HH....HHHHHHTTS--..-..SS-..HHHHHHHHHHHHHH.HHHH.HHHS-HHHH-HH.........................
#=GC seq_cons                        ...............................................h..............h....t.ppslhhshhEaa..h...t...t..pt..p.....ppt...h...lpc.p....a....p....p.....h....h....p....h....l.p.pl....lppGlcpGEFp..s..phs..hpslAphllshl-G.lhlp.shhht.......t........................
//
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