#=GF ID   Tk-SP_N-pro
#=GF AC   PF18237.5
#=GF DE   Tk-SP N-propeptide domain
#=GF AU   Smart A;0000-0002-6965-5633
#=GF SE   ECOD:EUF04991
#=GF GA   26.50 26.50;
#=GF TC   26.60 27.90;
#=GF NC   24.20 25.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0570
#=GF RN   [1]
#=GF RM   20595040
#=GF RT   Crystal structure of a subtilisin homologue, Tk-SP, from
#=GF RT   Thermococcus kodakaraensis: requirement of a C-terminal
#=GF RT   beta-jelly roll domain for hyperstability.
#=GF RA   Foophow T, Tanaka S, Angkawidjaja C, Koga Y, Takano K, Kanaya S;
#=GF RL   J Mol Biol. 2010;400:865-877.
#=GF DR   INTERPRO; IPR041326;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the N-propeptide domain found in Tk-SP, a
#=GF CC   subtilisin-like serine protease from Thermococcus kodakaraensis.
#=GF CC   The beta sheet of this domain packs tightly to the two nearly
#=GF CC   parallel alpha helices 2 and 3 located at the surface of the
#=GF CC   subtilisin domain. Gln105 and Asp107 of the N-propeptide domain
#=GF CC   also bind to the N-termini of these two alpha-helices to form
#=GF CC   helix caps [1].
#=GF SQ   22
#=GS S0FME8_RUMCE/47-114      AC S0FME8.1
#=GS L0L2B9_METHD/27-74       AC L0L2B9.1
#=GS A0A0A5I207_9BACI/56-128  AC A0A0A5I207.1
#=GS A0A8J3FD06_9BACI/43-110  AC A0A8J3FD06.1
#=GS A0A1I3U5D7_9BACL/47-113  AC A0A1I3U5D7.1
#=GS A0A235FFX0_9BACI/33-101  AC A0A235FFX0.1
#=GS A0A3Q9HPY2_9FIRM/41-105  AC A0A3Q9HPY2.1
#=GS Q8U0C9_PYRFU/37-103      AC Q8U0C9.1
#=GS A0A4E0Q582_9EURY/23-73   AC A0A4E0Q582.1
#=GS A0A4R3NCZ8_9BACI/52-120  AC A0A4R3NCZ8.1
#=GS TKSP_THEKO/37-103        AC Q5JIZ5.1
#=GS R7RSJ3_9CLOT/2-65        AC R7RSJ3.1
#=GS R1AR17_9FIRM/54-118      AC R1AR17.1
#=GS Q8RBJ2_CALS4/57-124      AC Q8RBJ2.1
#=GS A0A140KZU6_9CLOT/54-121  AC A0A140KZU6.1
#=GS A0A1B1Z1J5_9BACI/27-95   AC A0A1B1Z1J5.1
#=GS A0A1T5M656_9CLOT/54-119  AC A0A1T5M656.1
#=GS A0A7M1Q2N4_9CLOT/52-117  AC A0A7M1Q2N4.1
#=GS A0A1M6R337_9CLOT/54-121  AC A0A1M6R337.1
#=GS A0A4R3L6S8_9BACL/49-115  AC A0A4R3L6S8.1
#=GS A0A096BK00_9FIRM/54-121  AC A0A096BK00.1
#=GS A0A1C0A7K6_9FIRM/33-97   AC A0A1C0A7K6.1
S0FME8_RUMCE/47-114                 ....sp--NSKLFVNLEKKINE.......AKDSDEVPVTVVFN..K...KLTDDEFA.SIEKLLGNpEIKHKFEIIPGAALNLTKNQ...
L0L2B9_METHD/27-74                  ..aaqe----------------.......--KQEKVPVLINFK..E...KTDTE---.-LVKAHGG.NVKHEYTIIPAVAAEL----ppq
A0A0A5I207_9BACI/56-128             ......KDQNKLYDNLEQKLKE.......MQQNEKLPVIIQFDtsNmpgKSSKALDK.KLKNQVGKySTKHTYSVVKGVAATLNKKQ...
A0A8J3FD06_9BACI/43-110             .....h-NKNKLFDNLEQRLQA.......ARDDERLPVIVLFG..E...ADTARHLE.ELKRHVGPfSVKHAYGALSGFAAELTKRQ...
A0A1I3U5D7_9BACL/47-113             ...kgt----KYMSNLKNKMDQ.......ASDSENIPVIVTFK..T...KDQSSNLK.KAKSAVPNfSPKHVYKNIPAMSAKLTKSQ...
A0A235FFX0_9BACI/33-101             .....s-NSNKMLDNLEQKIKG.......LKNEEKVPVIIQFN..E...EFAGGKAYeKLAQKLGAfKKNFDYKVFNGMAATMTVKQ...
A0A3Q9HPY2_9FIRM/41-105             ......KDNDKIFDDLALKLKD.......ASDSDEFKVIAVFN..E...SYNLQ---.GIKNAIGHfATSYEYININAFAATLNKGQ...
Q8U0C9_PYRFU/37-103                 ......KNYGLLTPGLFRKIQK.......LNPNEEISTVIVFE..N...HREKEIAV.RVLELMGA.KVRYVYHIIPAIAADLKVRD...
A0A4E0Q582_9EURY/23-73              ...asa---------------K.......TNENEKVPVLITFK..G...TTDAD---.-LVKAHGG.NVKYEYTIIPSIAAELPQ--ka.
A0A4R3NCZ8_9BACI/52-120             ......KNGNKFFDNLEQKLDQ.......AKNDEKLPVIIQFD..T..sKVNSNAAN.ALQKRIGKfDVKYKYEIIDGVAATLTKKQ...
TKSP_THEKO/37-103                   ......KNYGLLTPGLFKKVQR.......MSWDQEVSTIIMFD..N...QADKEKAV.EILDFLGA.KIKYNYHIIPALAVKIKVKD...
R7RSJ3_9CLOT/2-65                   fwflnk------------KIDKklkeymnINSKRKIPVIVTYK..N...NLKSSKNS.IVYN--GG.KIKYEYKIINAIACEL----sp.
R1AR17_9FIRM/54-118                 ......KNNNKIFENLEKKLEK.......ASDKENLPVIVVFK..N...KPDKN---.NLKNILGNyKTKHEYKNIPAIAMELNKGQ...
Q8RBJ2_CALS4/57-124                 .....s-NKNKIFDDLEQRLLN.......KPDSEEFPVIITFN..K...PVSDADIF.TIAKNIGKfNIKHRYKIIPSIAANLTKSQ...
A0A140KZU6_9CLOT/54-121             ......ENKDKLFENLSKKMDK.......ANDDEEISVIVVFK..D...KLDTEKKG.KVKEVLGEyMAKHEYENIPAMAMKLKKGQ...
A0A1B1Z1J5_9BACI/27-95              .....l-NKNKLFDNLESKLQQ.......LTDEEKVPVIIQFN..E...EFAGGKAFeKLASKVGVfKKSFEYKVINGMAATMTKKQ...
A0A1T5M656_9CLOT/54-119             ......KNKDKIFESLSKEMKK.......TE--DELPVIIVFN..E...KSDKVKSN.NIKSLLGKyKVKHEYKNIPAAAMKLNKE-e..
A0A7M1Q2N4_9CLOT/52-117             .....t-NGDKVFENLQVQMDL.......AKEGVKIPVMVMFN..K...QVNTK--S.ELNTFMQGyEVKYQFQNIPAAVMELTKT-e..
A0A1M6R337_9CLOT/54-121             ......KDKDKLFENLSEKMNK.......AKDDEEISVIVVFE..E...KMNKVRNN.DMKMLLGSyKIKHEYKNIPAVAMKLNKGQ...
A0A4R3L6S8_9BACL/49-115             ...qgs----KLLSNLQNKISK.......VNHSEKLPVIITFK..N...LQQTSNLQ.ASKAKVPSlKAKHLYKNIPAIATELTKS-e..
A0A096BK00_9FIRM/54-121             .....s-NKDKLFENLSKKMDK.......VTDNEEIPVIVVFK..E...KLDSKRKI.FVNKLIGNyKIKHEYKNIPAIAMKLKKDQ...
A0A1C0A7K6_9FIRM/33-97              ......KNGNKIFEDLEEKLAE.......IKGNYKLDIIVVFN..K...NFTKK---.AIEAKIGAfDLKYNYKNINAFAGKLNKGQ...
#=GC seq_cons                       .......stsKla-sLppKlpc.......hpcsEclPVIlsFp..p...phsspt...plpphlGsaclKacYcsIPAhAscLsKpQ...
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