GenomeNet

Database: Pfam
Entry: Tlr3_TMD
LinkDB: Tlr3_TMD
Original site: Tlr3_TMD 
#=GF ID   Tlr3_TMD
#=GF AC   PF17968.2
#=GF DE   Toll-like receptor 3 trans-membrane domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF00255
#=GF GA   25.00 25.00;
#=GF TC   29.00 27.70;
#=GF NC   23.70 23.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   22611194
#=GF RT   Cleavage of Toll-like receptor 3 by cathepsins B and H is
#=GF RT   essential for signaling.
#=GF RA   Garcia-Cattaneo A, Gobert FX, Muller M, Toscano F, Flores M,
#=GF RA   Lescure A, Del Nery E, Benaroch P;
#=GF RL   Proc Natl Acad Sci U S A. 2012;109:9053-9058.
#=GF RN   [2]
#=GF RM   25217833
#=GF RT   Toll-like receptor 3 transmembrane domain is able to perform
#=GF RT   various homotypic interactions: an NMR structural study.
#=GF RA   Mineev KS, Goncharuk SA, Arseniev AS;
#=GF RL   FEBS Lett. 2014;588:3802-3807.
#=GF DR   INTERPRO; IPR041015;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Toll-like receptor (TLR) 3 is an endosomal TLR that mediates
#=GF CC   immune responses against viral infections upon activation by its
#=GF CC   ligand double-stranded RNA, a replication intermediate of most
#=GF CC   viruses. TLR3 is expressed widely in the body and activates both
#=GF CC   the innate and adaptive immune systems [1]. This entry
#=GF CC   represents the Toll-like receptor 3 trans-membrane domain which
#=GF CC   has been shown to form dimers and trimers with different
#=GF CC   surfaces for helix-helix interaction [2].
#=GF SQ   192
#=GS A0A1V4JG84_PATFA/711-743  AC A0A1V4JG84.1
#=GS A0A1S3G098_DIPOR/693-725  AC A0A1S3G098.1
#=GS A0A1U8D761_ALLSI/687-719  AC A0A1U8D761.1
#=GS A0A3B3X4N4_9TELE/720-752  AC A0A3B3X4N4.1
#=GS A0A151PAN3_ALLMI/741-773  AC A0A151PAN3.1
#=GS W5LLV4_ASTMX/702-730      AC W5LLV4.2
#=GS A0A3B5K0I8_TAKRU/692-724  AC A0A3B5K0I8.1
#=GS A0A2I2U8P0_FELCA/698-730  AC A0A2I2U8P0.1
#=GS A0A3Q1BCR0_AMPOC/706-738  AC A0A3Q1BCR0.1
#=GS A0A3B3QR36_9TELE/689-721  AC A0A3B3QR36.1
#=GS A0A091X5I6_NIPNI/692-724  AC A0A091X5I6.1
#=GS F6TNZ8_MONDO/699-731      AC F6TNZ8.1
#=GS A0A3B4V526_SERDU/708-740  AC A0A3B4V526.1
#=GS A0A096MRL8_PAPAN/698-730  AC A0A096MRL8.2
#=GS A0A383ZGP4_BALAS/699-731  AC A0A383ZGP4.1
#=GS G3W1A7_SARHA/488-520      AC G3W1A7.1
#=GS A0A498NLM7_LABRO/657-689  AC A0A498NLM7.1
#=GS A0A3P8WBG4_CYNSE/709-741  AC A0A3P8WBG4.1
#=GS A0A3L8SVB5_CHLGU/688-720  AC A0A3L8SVB5.1
#=GS A0A3B4CRH7_PYGNA/703-733  AC A0A3B4CRH7.1
#=GS A0A3P9MS72_POERE/701-733  AC A0A3P9MS72.1
#=GS A0A1U8DIS6_ALLSI/698-730  AC A0A1U8DIS6.1
#=GS A0A2K6BS81_MACNE/698-730  AC A0A2K6BS81.1
#=GS A0A1U7T2I6_TARSY/699-731  AC A0A1U7T2I6.1
#=GS A0A3Q2CYC8_CYPVA/699-731  AC A0A3Q2CYC8.1
#=GS A3QRJ8_CAVPO/699-731      AC A3QRJ8.1
#=GS A0A3B1IJC0_ASTMX/697-725  AC A0A3B1IJC0.1
#=GS A0A452I7M1_9SAUR/689-721  AC A0A452I7M1.1
#=GS A0A401S9G2_CHIPU/692-724  AC A0A401S9G2.1
#=GS A0A226PDG8_COLVI/715-747  AC A0A226PDG8.1
#=GS A0A4D9FE74_9SAUR/688-720  AC A0A4D9FE74.1
#=GS F7E2D3_ORNAN/565-597      AC F7E2D3.1
#=GS A0A2Y9DYK3_TRIMA/717-749  AC A0A2Y9DYK3.1
#=GS A0A3Q1F0G8_9TELE/713-745  AC A0A3Q1F0G8.1
#=GS G1NFY1_MELGA/690-722      AC G1NFY1.2
#=GS A0A3B5AZZ4_9TELE/704-736  AC A0A3B5AZZ4.1
#=GS A0A498MXK7_LABRO/561-593  AC A0A498MXK7.1
#=GS A0A226MN15_CALSU/689-721  AC A0A226MN15.1
#=GS A0A3B3QSK0_9TELE/709-741  AC A0A3B3QSK0.1
#=GS M7BVR6_CHEMY/753-785      AC M7BVR6.1
#=GS A0A3Q3LK40_9TELE/720-752  AC A0A3Q3LK40.1
#=GS A0A384DNP2_URSMA/699-731  AC A0A384DNP2.1
#=GS G1K9T8_ANOCA/684-716      AC G1K9T8.2
#=GS A0A3P8RHC1_ASTCA/704-736  AC A0A3P8RHC1.1
#=GS M3YII7_MUSPF/558-590      AC M3YII7.1
#=GS L9JDM1_TUPCH/433-465      AC L9JDM1.1
#=GS K7FVS4_PELSI/689-721      AC K7FVS4.1
#=GS A0A2R8RPU1_DANRE/698-730  AC A0A2R8RPU1.1
#=GS A0A3Q3W8P1_MOLML/714-746  AC A0A3Q3W8P1.1
#=GS F7DWP4_MACMU/698-730      AC F7DWP4.1
#=GS F7I1W0_CALJA/698-730      AC F7I1W0.2
#=GS A0A3Q3CYC1_HAPBU/767-799  AC A0A3Q3CYC1.1
#=GS A0A383ZFV5_BALAS/751-783  AC A0A383ZFV5.1
#=GS A0A401NSL9_SCYTO/695-727  AC A0A401NSL9.1
#=GS A0A3P9MRV2_POERE/675-707  AC A0A3P9MRV2.1
#=GS A0A3Q2HFC7_HORSE/702-734  AC A0A3Q2HFC7.1
#=GS A0A3Q3F428_KRYMA/712-744  AC A0A3Q3F428.1
#=GS A0A2Y9RHI0_TRIMA/699-731  AC A0A2Y9RHI0.1
#=GS A0A3Q3W8N7_MOLML/709-741  AC A0A3Q3W8N7.1
#=GS A0A2I4BGS2_9TELE/711-743  AC A0A2I4BGS2.1
#=GS A0A2I0MMS5_COLLI/688-720  AC A0A2I0MMS5.1
#=GS A0A0P7UXN1_SCLFO/775-807  AC A0A0P7UXN1.1
#=GS A0A093PY65_9PASS/692-724  AC A0A093PY65.1
#=GS A0A493T7B3_ANAPP/688-720  AC A0A493T7B3.1
#=GS A0A2K5ZLK5_MANLE/698-730  AC A0A2K5ZLK5.1
#=GS B3Y621_PANPA/698-730      AC B3Y621.1
#=GS A0A3Q1I4M8_ANATE/711-743  AC A0A3Q1I4M8.1
#=GS A0A0Q3M4S4_AMAAE/704-736  AC A0A0Q3M4S4.1
#=GS A0A3Q3W0K1_MOLML/693-725  AC A0A3Q3W0K1.1
#=GS H2LVZ0_ORYLA/711-743      AC H2LVZ0.2
#=GS A0A2K6NBK5_RHIRO/698-730  AC A0A2K6NBK5.1
#=GS W5PDY1_SHEEP/699-731      AC W5PDY1.1
#=GS A0A452ESC2_CAPHI/699-731  AC A0A452ESC2.1
#=GS A0A2K5LDS9_CERAT/698-730  AC A0A2K5LDS9.1
#=GS W5N8T7_LEPOC/699-731      AC W5N8T7.1
#=GS A0A099ZFZ8_TINGU/693-725  AC A0A099ZFZ8.1
#=GS A0A1S2ZDK1_ERIEU/699-731  AC A0A1S2ZDK1.1
#=GS A0A3Q4GPR4_NEOBR/706-738  AC A0A3Q4GPR4.1
#=GS A0A498L999_LABRO/657-689  AC A0A498L999.1
#=GS A0A3B4YSH9_SERLL/705-737  AC A0A3B4YSH9.1
#=GS A0A3P8RHB6_ASTCA/704-736  AC A0A3P8RHB6.1
#=GS A0A3B3ZSP5_9GOBI/704-736  AC A0A3B3ZSP5.1
#=GS A0A3P9MS69_POERE/718-750  AC A0A3P9MS69.1
#=GS A0A2U3YDS3_LEPWE/699-731  AC A0A2U3YDS3.1
#=GS A0A452ESD4_CAPHI/699-731  AC A0A452ESD4.1
#=GS A0A1L8HTX4_XENLA/691-721  AC A0A1L8HTX4.1
#=GS A0A3B3ZRM0_9GOBI/684-716  AC A0A3B3ZRM0.1
#=GS A0A2U4A859_TURTR/720-752  AC A0A2U4A859.1
#=GS Q3KUR8_ONCMY/707-739      AC Q3KUR8.1
#=GS A0A3B4G4J0_9CICH/706-738  AC A0A3B4G4J0.1
#=GS A0A384DNW8_URSMA/635-667  AC A0A384DNW8.1
#=GS A0A1S3FY67_DIPOR/557-589  AC A0A1S3FY67.1
#=GS R0M8K4_ANAPL/692-724      AC R0M8K4.1
#=GS A0A3B3ZRP3_9GOBI/704-736  AC A0A3B3ZRP3.1
#=GS A0A2K5WT39_MACFA/698-730  AC A0A2K5WT39.1
#=GS B3Y620_PANTR/698-730      AC B3Y620.1
#=GS TLR3_BOVIN/699-731        AC Q5TJ59.1
#=GS A0A3P9MS90_POERE/718-750  AC A0A3P9MS90.1
#=GS A0A3P8RRB2_AMPPE/706-738  AC A0A3P8RRB2.1
#=GS A0A3B3ZRK5_9GOBI/704-736  AC A0A3B3ZRK5.1
#=GS A0A2Y9N0N8_DELLE/699-731  AC A0A2Y9N0N8.1
#=GS A0A3Q1EXE2_9TELE/706-738  AC A0A3Q1EXE2.1
#=GS F7CCY6_HORSE/698-730      AC F7CCY6.2
#=GS A0A3Q2GZW1_HORSE/698-730  AC A0A3Q2GZW1.1
#=GS A0A3Q3E9U2_9LABR/708-740  AC A0A3Q3E9U2.1
#=GS A0A1S3RFT8_SALSA/707-739  AC A0A1S3RFT8.1
#=GS A0A3Q7VTD8_URSAR/699-731  AC A0A3Q7VTD8.1
#=GS A0A091FV07_CORBR/692-724  AC A0A091FV07.1
#=GS A0A3P9MRY3_POERE/704-736  AC A0A3P9MRY3.1
#=GS A0A091K5F1_EGRGA/692-724  AC A0A091K5F1.1
#=GS H0XRB8_OTOGA/699-731      AC H0XRB8.1
#=GS A0A3B4V521_SERDU/716-748  AC A0A3B4V521.1
#=GS A0A093HRS4_STRCA/692-724  AC A0A093HRS4.1
#=GS A0A2U3WU34_ODORO/704-736  AC A0A2U3WU34.1
#=GS F1LN63_RAT/699-731        AC F1LN63.1
#=GS H2SIG3_TAKRU/679-711      AC H2SIG3.2
#=GS A0A3S5ZPK8_BOVIN/699-731  AC A0A3S5ZPK8.1
#=GS A0A091WJS5_OPIHO/692-724  AC A0A091WJS5.1
#=GS A0A2K5K048_COLAP/698-730  AC A0A2K5K048.1
#=GS G3TJ47_LOXAF/699-731      AC G3TJ47.1
#=GS H3CNU2_TETNG/706-738      AC H3CNU2.1
#=GS U3KBQ5_FICAL/689-721      AC U3KBQ5.1
#=GS A0A3B5R7K0_XIPMA/673-705  AC A0A3B5R7K0.1
#=GS A0A3B3ZS33_9GOBI/701-733  AC A0A3B3ZS33.1
#=GS F6YQH2_XENTR/695-725      AC F6YQH2.1
#=GS G3PXE9_GASAC/705-737      AC G3PXE9.1
#=GS G1TED9_RABIT/699-731      AC G1TED9.1
#=GS A0A3B4V5I7_SERDU/716-748  AC A0A3B4V5I7.1
#=GS M3X2Z3_FELCA/698-730      AC M3X2Z3.1
#=GS A0A402ES77_9SAUR/712-744  AC A0A402ES77.1
#=GS H0Z936_TAEGU/681-713      AC H0Z936.1
#=GS A0A3P9MRX7_POERE/704-736  AC A0A3P9MRX7.1
#=GS G3UR58_MELGA/634-666      AC G3UR58.1
#=GS A0A0D9S2K8_CHLSB/698-730  AC A0A0D9S2K8.1
#=GS U3IN40_ANAPP/688-720      AC U3IN40.2
#=GS A0A3Q1IAP2_ANATE/720-752  AC A0A3Q1IAP2.1
#=GS A0A091DSL2_FUKDA/213-245  AC A0A091DSL2.1
#=GS F1RZN4_PIG/697-729        AC F1RZN4.3
#=GS A0A3B3B8M9_ORYME/707-739  AC A0A3B3B8M9.1
#=GS A0A2K6F645_PROCO/699-731  AC A0A2K6F645.1
#=GS H2PEX1_PONAB/698-730      AC H2PEX1.1
#=GS A0A3B4V6Q7_SERDU/716-748  AC A0A3B4V6Q7.1
#=GS A0A2U9BPS5_SCOMX/709-741  AC A0A2U9BPS5.1
#=GS A0A2U4A8B1_TURTR/699-731  AC A0A2U4A8B1.1
#=GS A0A3P8RFA1_ASTCA/757-789  AC A0A3P8RFA1.1
#=GS A0A340XZ05_LIPVE/750-782  AC A0A340XZ05.1
#=GS A0A3P9BI49_9CICH/706-738  AC A0A3P9BI49.1
#=GS TLR3_MOUSE/699-731        AC Q99MB1.2
#=GS A0A3B3ZRL4_9GOBI/697-729  AC A0A3B3ZRL4.1
#=GS I3NCY9_ICTTR/699-731      AC I3NCY9.1
#=GS A0A3Q7ULL1_VULVU/699-731  AC A0A3Q7ULL1.1
#=GS A0A1A6GIZ9_NEOLE/483-515  AC A0A1A6GIZ9.1
#=GS G1PKT6_MYOLU/699-731      AC G1PKT6.1
#=GS A0A3Q0T2H1_AMPCI/715-747  AC A0A3Q0T2H1.1
#=GS A0A2K5QK98_CEBCA/698-730  AC A0A2K5QK98.1
#=GS A0A2Y9FMG0_PHYMC/781-813  AC A0A2Y9FMG0.2
#=GS A0A2K5CME7_AOTNA/698-730  AC A0A2K5CME7.1
#=GS H3ATI5_LATCH/558-589      AC H3ATI5.1
#=GS A0A1S3W4P8_ERIEU/707-739  AC A0A1S3W4P8.1
#=GS A0A1U7QIC2_MESAU/699-731  AC A0A1U7QIC2.1
#=GS A0A2K6TZX6_SAIBB/698-730  AC A0A2K6TZX6.1
#=GS G3SGL1_GORGO/698-730      AC G3SGL1.2
#=GS A0A093IPK7_DRYPU/692-724  AC A0A093IPK7.1
#=GS A0A3Q2CY54_CYPVA/705-737  AC A0A3Q2CY54.1
#=GS TLR3_HUMAN/698-730        AC O15455.1
#=GS TLR3_HUMAN/698-730        DR PDB; 2MK9 A; 2-34;
#=GS TLR3_HUMAN/698-730        DR PDB; 2MK9 B; 102-134;
#=GS TLR3_HUMAN/698-730        DR PDB; 2MKA C; 202-234;
#=GS TLR3_HUMAN/698-730        DR PDB; 2MKA A; 2-34;
#=GS TLR3_HUMAN/698-730        DR PDB; 2MKA B; 102-134;
#=GS A0A2Y9FLX4_PHYMC/699-731  AC A0A2Y9FLX4.1
#=GS A0A218VFJ9_9PASE/689-721  AC A0A218VFJ9.1
#=GS A0A2K6K9A3_RHIBE/698-729  AC A0A2K6K9A3.1
#=GS B8JIL3_DANRE/698-730      AC B8JIL3.1
#=GS E2RIV9_CANLF/699-731      AC E2RIV9.2
#=GS A0A3P9AIV7_ESOLU/705-737  AC A0A3P9AIV7.1
#=GS Q00L02_ICTPU/698-730      AC Q00L02.1
#=GS A0A3Q0T2H8_AMPCI/715-747  AC A0A3Q0T2H8.1
#=GS A0A1L4FLT3_CHICK/689-721  AC A0A1L4FLT3.1
#=GS A0A1B0GS40_MOUSE/175-207  AC A0A1B0GS40.1
#=GS A0A3Q3E9V8_9LABR/715-747  AC A0A3Q3E9V8.1
#=GS A0A3M0KLV2_HIRRU/689-721  AC A0A3M0KLV2.1
#=GS G1RKY9_NOMLE/698-730      AC G1RKY9.1
#=GS G5BNV5_HETGA/699-731      AC G5BNV5.1
#=GS A0A3B3W012_9TELE/707-739  AC A0A3B3W012.1
#=GS M4AWR4_XIPMA/707-739      AC M4AWR4.1
#=GS M1ZMQ4_SALSA/707-739      AC M1ZMQ4.1
#=GS A0A3B3ZRL9_9GOBI/707-739  AC A0A3B3ZRL9.1
#=GS D2HM22_AILME/699-731      AC D2HM22.1
#=GS A0A3Q7TAC3_VULVU/568-600  AC A0A3Q7TAC3.1
#=GS A0A087XJ58_POEFO/710-742  AC A0A087XJ58.1
#=GS S4R995_PETMA/707-739      AC S4R995.1
#=GS I3JV98_ORENI/706-738      AC I3JV98.1
#=GS A0A3Q7TW86_VULVU/699-731  AC A0A3Q7TW86.1
#=GS A0A452RKA0_URSAM/699-731  AC A0A452RKA0.1
#=GS H2SIG4_TAKRU/684-716      AC H2SIG4.2
#=GS A0A2Y9J4G3_ENHLU/699-731  AC A0A2Y9J4G3.1
A0A1V4JG84_PATFA/711-743             ..DSAPFKLLFVVTTTTVMLIIFMVLIIHFEGWRI..
A0A1S3G098_DIPOR/693-725             ..DSAPFKLLFMINTSVLLIFILVVLLIHFEGWRL..
A0A1U8D761_ALLSI/687-719             ..DSAPFKLLYIISTTVVLLLIIIATLIQFEGWRI..
A0A3B3X4N4_9TELE/720-752             ..DMAPFQAFYVLNSTIVLMLILTALIYRFHGWRI..
A0A151PAN3_ALLMI/741-773             ..DSAPFKLLYIISTTVVLLLIIIATLIQFEGWRI..
W5LLV4_ASTMX/702-730                 ..----FQGLYTFSSTMVLGLMAIAFLVHFQGWRI..
A0A3B5K0I8_TAKRU/692-724             ..DMTPFRALYVVSSTTVILLLTVALFMRFHGWRI..
A0A2I2U8P0_FELCA/698-730             ..DSAPFELFFIINTSILLIFIFTVLLIHFEGWRI..
A0A3Q1BCR0_AMPOC/706-738             ..DMTPFQALYILSSTAVISLIVMALLVRFHGWRI..
A0A3B3QR36_9TELE/689-721             ..DMTPFQTLFVLSSTTVLVLMGTALLLRFQGWRI..
A0A091X5I6_NIPNI/692-724             ..DSAPFKLLFVITTSVVLLVIFIVLIIHFEGWRI..
F6TNZ8_MONDO/699-731                 ..DSAPFKMFFIINASFLCTLIFVVLLVHFQGWRI..
A0A3B4V526_SERDU/708-740             ..DMTPFQALYVLSSTVVLMLMVTALVVRFHGWRI..
A0A096MRL8_PAPAN/698-730             ..DSAPFELLFMINTSILLIFIFVVLLIHFEGWRI..
A0A383ZGP4_BALAS/699-731             ..DSAPFELLFMINTSILLIFIFIVLLIHFEGWKI..
G3W1A7_SARHA/488-520                 ..DSAPFKILFMINTSFLFILIFVVMLVHFQGWRI..
A0A498NLM7_LABRO/657-689             ..DMTPFKALYILSSTAVLMLLFSAFLVHFQGWRI..
A0A3P8WBG4_CYNSE/709-741             ..DMVPFQALYIFSSTAVLLLMATAFLVRFQGWRI..
A0A3L8SVB5_CHLGU/688-720             ..DSAPFKLLFMISTTIVMLFIFIVLTIHFEGWRI..
A0A3B4CRH7_PYGNA/703-733             tl----FQALYVLSSTLVLGLMVIAFLVHFQGWRI..
A0A3P9MS72_POERE/701-733             ..DMTPFQAFYVLNSTAVLMLILTALIYRFHGWRI..
A0A1U8DIS6_ALLSI/698-730             ..DSAPFKLLYIISTTVVLLLIIIATLIQFEGWRI..
A0A2K6BS81_MACNE/698-730             ..DSAPFELFFMINTSILLIFIFVVLLIHFEGWRI..
A0A1U7T2I6_TARSY/699-731             ..DSAPFELLFTVNTTILLSFIFIVLLIHFESWRI..
A0A3Q2CYC8_CYPVA/699-731             ..DMTPFQVLYILTSTAVLLLMCSAFIYRFHGWRI..
A3QRJ8_CAVPO/699-731                 ..DSAPFELFFMISTSVLLIFIFIVLLIHFEGWRI..
A0A3B1IJC0_ASTMX/697-725             ..----FQGLYTFSSTMVLGLMAIAFLVHFQGWRI..
A0A452I7M1_9SAUR/689-721             ..DSAPFKLLYIISTTVIMLLIFIVVLIHFEGWRI..
A0A401S9G2_CHIPU/692-724             ..DVAPFKDAFVISSSIILLLIFTVFLIHFRGW--wl
A0A226PDG8_COLVI/715-747             ..DSAPFKLLFVITTTVVLQVIIIVLLIHFEGWRI..
A0A4D9FE74_9SAUR/688-720             ..DSAPFKLLYIISATVIMLLIFIVILIHFEGWRI..
F7E2D3_ORNAN/565-597                 ..DSAPFDMFFMVSASALFLFTSGVLLARFQGWRL..
A0A2Y9DYK3_TRIMA/717-749             ..DSAPFELLFVINTSTLLFFIFIVLLVHFEGWRI..
A0A3Q1F0G8_9TELE/713-745             ..DMTPFQALFILSSTAVISLIVTALLVRFHGWRI..
G1NFY1_MELGA/690-722                 ..DSAPFKLLFVITTTVVMQFIFIVLLIHFEGWRI..
A0A3B5AZZ4_9TELE/704-736             ..DMTPFQALYILSSTAVITLIVIALLVRFHGWRI..
A0A498MXK7_LABRO/561-593             ..DMTPFKALYILSSTAVLMLLFSAFLVHFQGWRI..
A0A226MN15_CALSU/689-721             ..DSAPFKLLFVITTTVVLQVIMIVLLIHFEGWRI..
A0A3B3QSK0_9TELE/709-741             ..DMTPFQTLFVLSSTTVLVLMGTALLLRFQGWRI..
M7BVR6_CHEMY/753-785                 ..DSAPFQLLYIISTTVIMLFIFIVILIHFEGWRI..
A0A3Q3LK40_9TELE/720-752             ..DLTPFQALYIMSSTAVMMLLVTALLVRFHGWQI..
A0A384DNP2_URSMA/699-731             ..DSAPFELFFIINTSVSLIFIFIVLLIHFEGWRI..
G1K9T8_ANOCA/684-716                 ..DSAPFLLFFTVSISILLIFISVVLLIHFQGWRI..
A0A3P8RHC1_ASTCA/704-736             ..DMTPFQTLYIVSSTAVILLIVTALTVRFHDWRI..
M3YII7_MUSPF/558-590                 ..DSAPFELFFIINTSFSLIFIFLVLLIHFEGWRI..
L9JDM1_TUPCH/433-465                 ..DSAPFELLFMISTSMLSIFIFVILLIHFEGWRI..
K7FVS4_PELSI/689-721                 ..DSAPFKLLYIISTTLIMLLIFIVILIHFEGWRI..
A0A2R8RPU1_DANRE/698-730             ..DMTPFKALYILSSTAVLMLLFISFLVHFQGWRI..
A0A3Q3W8P1_MOLML/714-746             ..DMTPFQALYIVSSTAIIMLIVSALLVRFHGWRI..
F7DWP4_MACMU/698-730                 ..DSAPFELFFIINTSILLIFIFVVLLIHFEGWRI..
F7I1W0_CALJA/698-730                 ..DSAPFELFFMISTSILLTFIFIVLLIHFEGWRI..
A0A3Q3CYC1_HAPBU/767-799             ..DMTPFQTLYIVSSTAVILLIVTALTVRFHDWRI..
A0A383ZFV5_BALAS/751-783             ..DSAPFELLFMINTSILLIFIFIVLLIHFEGWKI..
A0A401NSL9_SCYTO/695-727             ..DVAPFAGAFIISSSFILGIIFTVFLIQFQGWRL..
A0A3P9MRV2_POERE/675-707             ..DMTPFQAFYVLNSTAVLMLILTALIYRFHGWRI..
A0A3Q2HFC7_HORSE/702-734             ..DSAPFELLFMINTSFLLIFIFIVLLIHFEGWRI..
A0A3Q3F428_KRYMA/712-744             ..DMTPFQALYILSSTAVLMLITGALLARFHGWRI..
A0A2Y9RHI0_TRIMA/699-731             ..DSAPFELLFVINTSTLLFFIFIVLLVHFEGWRI..
A0A3Q3W8N7_MOLML/709-741             ..DMTPFQALYIVSSTAIIMLIVSALLVRFHGWRI..
A0A2I4BGS2_9TELE/711-743             ..DMTPFQALFILSSTVVLMLIIGAFLVRFQGWRI..
A0A2I0MMS5_COLLI/688-720             ..DGAPFKLLFVVTTTTVMLIIFMVLIIHFEGWRI..
A0A0P7UXN1_SCLFO/775-807             ..DTTPFQALYVFTSTTVLIVMATALVFHFQGWRI..
A0A093PY65_9PASS/692-724             ..DSAPFKLLFVISTTVVMVLIFIVLTIHFEGWRI..
A0A493T7B3_ANAPP/688-720             ..DSAPFKLLFMITTTAVMLLIFIVLLIHFEGWRI..
A0A2K5ZLK5_MANLE/698-730             ..DSAPFELLFMINTSILLLFIFVVLLIHFEGWRI..
B3Y621_PANPA/698-730                 ..DSAPFELFFMINTSILLIFIFIVLLIHFQGWRI..
A0A3Q1I4M8_ANATE/711-743             ..DMTPFQALYILSSTVVIMLMVTALLVRFHGWRI..
A0A0Q3M4S4_AMAAE/704-736             ..DSAPFKLLFVITATAVTLFIFIVLIIHFEGWRI..
A0A3Q3W0K1_MOLML/693-725             ..DMTPFQALYIVSSTAIIMLIVSALLVRFHGWRI..
H2LVZ0_ORYLA/711-743                 ..DKTPFQALYMLSSTAVLIMMVSALLVRFQGWRI..
A0A2K6NBK5_RHIRO/698-730             ..DSAPFELFFMISTSILLIFIFVVLLIHFEGWRI..
W5PDY1_SHEEP/699-731                 ..DSAPFELLFMINTNILLIFIFIVLLIHFEGWRI..
A0A452ESC2_CAPHI/699-731             ..DSAPFELLFMINTNILLIFIFIVLLIHFEGWRI..
A0A2K5LDS9_CERAT/698-730             ..DSAPFELLFMINTSILLLFIFVVLLIHFEGWRI..
W5N8T7_LEPOC/699-731                 ..DQAPFKPMFVTTSSFLLTFMAMALLIHFQGWRI..
A0A099ZFZ8_TINGU/693-725             ..DSAPFQLLFVITTTAVMLLIFIVFLTHFEGWRI..
A0A1S2ZDK1_ERIEU/699-731             ..DSAPFELLFMINTSFLLIFIFNVLLIHFEGWRI..
A0A3Q4GPR4_NEOBR/706-738             ..DMTPFQTLYIVSSTAVILLIVTALTVRFHDWRI..
A0A498L999_LABRO/657-689             ..DMTPFKALYILSSTAVLMLLFSAFLVHFQGWRI..
A0A3B4YSH9_SERLL/705-737             ..DMTPFQALYVLSSTAVLMLMVTALVVRFHGWRI..
A0A3P8RHB6_ASTCA/704-736             ..DMTPFQTLYIVSSTAVILLIVTALTVRFHDWRI..
A0A3B3ZSP5_9GOBI/704-736             ..DTTPFQALYILSSTTVLLLMVTALVVRFQGWRI..
A0A3P9MS69_POERE/718-750             ..DMTPFQAFYVLNSTAVLMLILTALIYRFHGWRI..
A0A2U3YDS3_LEPWE/699-731             ..DSAPFKLFFIINTSVSLIFIVIVLLIHFEGWRI..
A0A452ESD4_CAPHI/699-731             ..DSAPFELLFMINTNILLIFIFIVLLIHFEGWRI..
A0A1L8HTX4_XENLA/691-721             .l--APFR-LFVSTFSLTLVFILLVLLIQFQGWRI..
A0A3B3ZRM0_9GOBI/684-716             ..DTTPFQALYILSSTTVLLLMVTALVVRFQGWRI..
A0A2U4A859_TURTR/720-752             ..DSAPFELLFMINTSILLIFILIVLLIHFEGWKI..
Q3KUR8_ONCMY/707-739                 ..DMTPFQALYVLTSTAVLTLMVTSLLVRFQGWRI..
A0A3B4G4J0_9CICH/706-738             ..DMTPFQTLYIVSSTAVILLIVTALTVRFHDWRI..
A0A384DNW8_URSMA/635-667             ..DSAPFELFFIINTSVSLIFIFIVLLIHFEGWRI..
A0A1S3FY67_DIPOR/557-589             ..DSAPFKLLFMINTSVLLIFILVVLLIHFEGWRL..
R0M8K4_ANAPL/692-724                 ..DSAPFKLLFMITTTAVMLLIFIVLLIHFEGWRI..
A0A3B3ZRP3_9GOBI/704-736             ..DTTPFQALYILSSTTVLLLMVTALVVRFQGWRI..
A0A2K5WT39_MACFA/698-730             ..DSAPFELFFMINTSILLIFIFVVLLIHFEGWRI..
B3Y620_PANTR/698-730                 ..DSAPFELFFMINTSILLIFIFIVLLIHFQGWRI..
TLR3_BOVIN/699-731                   ..DSAPFELLFMININILLIFIFIVLLIHFEGWRI..
A0A3P9MS90_POERE/718-750             ..DMTPFQAFYVLNSTAVLMLILTALIYRFHGWRI..
A0A3P8RRB2_AMPPE/706-738             ..DMTPFQALYILSSTAVISLIVMALLVRFHGWRI..
A0A3B3ZRK5_9GOBI/704-736             ..DTTPFQALYILSSTTVLLLMVTALVVRFQGWRI..
A0A2Y9N0N8_DELLE/699-731             ..DSAPFELLFMINTSILLIFILLVLLIHFEGWKI..
A0A3Q1EXE2_9TELE/706-738             ..DMTPFQALFILSSTAVISLIVTALLVRFHGWRI..
F7CCY6_HORSE/698-730                 ..DSAPFELLFMINTSFLLIFIFIVLLIHFEGWRI..
A0A3Q2GZW1_HORSE/698-730             ..DSAPFELLFMINTSFLLIFIFIVLLIHFEGWRI..
A0A3Q3E9U2_9LABR/708-740             ..DMTPFQALYILSSTAVLMLMVTALLVRFHGWRI..
A0A1S3RFT8_SALSA/707-739             ..DMTPFQALYVLTSTAVLTLMVTSLLVRFQGWRI..
A0A3Q7VTD8_URSAR/699-731             ..DSAPFELFFIINTSVSLIFIFIVLLIHFEGWRI..
A0A091FV07_CORBR/692-724             ..DSAPFKLLFVISATIVTLLIFIVLTIHFEGWRI..
A0A3P9MRY3_POERE/704-736             ..DMTPFQAFYVLNSTAVLMLILTALIYRFHGWRI..
A0A091K5F1_EGRGA/692-724             ..DSAPFKLLFVITSTVVMLVIFIVLIIHFEGWRI..
H0XRB8_OTOGA/699-731                 ..DSAPFELLFMINTSILLFFIFIILLVHFEGWRI..
A0A3B4V521_SERDU/716-748             ..DMTPFQALYVLSSTVVLMLMVTALVVRFHGWRI..
A0A093HRS4_STRCA/692-724             ..DSAPFKLLFVITTTVVMLLIFIVLLAHFEGWRI..
A0A2U3WU34_ODORO/704-736             ..DSAPFKLFFIINTSVSLIFIVIVLLIHFEGWRI..
F1LN63_RAT/699-731                   ..DSAPFQLLFIINTSTLLTFILAVLLIHFEGWRI..
H2SIG3_TAKRU/679-711                 ..DMTPFRALYVVSSTTVILLLTVALFMRFHGWRI..
A0A3S5ZPK8_BOVIN/699-731             ..DSAPFELLFMININILLIFIFIVLLIHFEGWRI..
A0A091WJS5_OPIHO/692-724             ..DSAPFKLLFVISTTIVTLVIFTVLTIHFEGWRI..
A0A2K5K048_COLAP/698-730             ..DSAPFELFFMINTSILLIFIFVVLLIHFEGWRI..
G3TJ47_LOXAF/699-731                 ..DSAPFELLFVINTSTLLFFIFIVLLVHFEGWRI..
H3CNU2_TETNG/706-738                 ..DSTPFQALFVLSSASVILLLVVALFVRFQGWRI..
U3KBQ5_FICAL/689-721                 ..DSAPFQLLFVISSTIVTLLIFVVLTIHFEGWRI..
A0A3B5R7K0_XIPMA/673-705             ..DMAPFQAFYVLNSTAVLMLILTALIYRFHGWRI..
A0A3B3ZS33_9GOBI/701-733             ..DTTPFQALYILSSTTVLLLMVTALVVRFQGWRI..
F6YQH2_XENTR/695-725                 .l--APFR-LFVSTFSLMLVFILSVLLIQFQGWRI..
G3PXE9_GASAC/705-737                 ..DMTPFQALYILSSTVVITLMVSALLVRFQGWRI..
G1TED9_RABIT/699-731                 ..DSAPFELLFMINTSFLLLFIFIVLLIHFEGWRI..
A0A3B4V5I7_SERDU/716-748             ..DMTPFQALYVLSSTVVLMLMVTALVVRFHGWRI..
M3X2Z3_FELCA/698-730                 ..DSAPFELFFIINTSILLIFIFTVLLIHFEGWRI..
A0A402ES77_9SAUR/712-744             ..DNAPFKLFFIVSTTVILLLIFVVLLIHFLGWKI..
H0Z936_TAEGU/681-713                 ..DSAPFKLLFVISTTIVMVFIFVVLTIHFEGWRI..
A0A3P9MRX7_POERE/704-736             ..DMTPFQAFYVLNSTAVLMLILTALIYRFHGWRI..
G3UR58_MELGA/634-666                 ..DSAPFKLLFVITTTVVMQFIFIVLLIHFEGWRI..
A0A0D9S2K8_CHLSB/698-730             ..DSAPFELFFMINTSILLIFILVVLLIHFEGWRI..
U3IN40_ANAPP/688-720                 ..DSAPFKLLFMITTTAVMLLIFIVLLIHFEGWRI..
A0A3Q1IAP2_ANATE/720-752             ..DMTPFQALYILSSTVVIMLMVTALLVRFHGWRI..
A0A091DSL2_FUKDA/213-245             ..DSAPFELFFVVSTSLLFTFIFIVFLIRFEGWRI..
F1RZN4_PIG/697-729                   ..DSAPFELFFMITASMLLIFIFIILLIHFEGWRI..
A0A3B3B8M9_ORYME/707-739             ..DTTPFQALYMLSSTVVLIMMVSAFLIRFQGWRI..
A0A2K6F645_PROCO/699-731             ..DSAPFELLFMINTGILLIFIFIILLIHFEGWRI..
H2PEX1_PONAB/698-730                 ..DSAPFELFFMINTSILLIFIFIVLLIHFEGWRI..
A0A3B4V6Q7_SERDU/716-748             ..DMTPFQALYVLSSTVVLMLMVTALVVRFHGWRI..
A0A2U9BPS5_SCOMX/709-741             ..DMTPFQALYILTSTTVMAVIVTALLVRFQGWRI..
A0A2U4A8B1_TURTR/699-731             ..DSAPFELLFMINTSILLIFILIVLLIHFEGWKI..
A0A3P8RFA1_ASTCA/757-789             ..DMTPFQTLYIVSSTAVILLIVTALTVRFHDWRI..
A0A340XZ05_LIPVE/750-782             ..DSAPFELLFMINTSILLIFILIVLLIHFEGWKI..
A0A3P9BI49_9CICH/706-738             ..DMTPFQTLYIVSSTAVILLIVTALTVRFHDWRI..
TLR3_MOUSE/699-731                   ..DSAPFELLFIISTSMLLVFILVVLLIHIEGWRI..
A0A3B3ZRL4_9GOBI/697-729             ..DTTPFQALYILSSTTVLLLMVTALVVRFQGWRI..
I3NCY9_ICTTR/699-731                 ..DSAPFELLFMISTSMILIFIIVVLLIHLEGWRI..
A0A3Q7ULL1_VULVU/699-731             ..DSAPFEIFFIINTSVLLTFIFIVLLIHFEGWRI..
A0A1A6GIZ9_NEOLE/483-515             ..DSAPFELLFMINTSVLMIFILMALLIHFEGWRI..
G1PKT6_MYOLU/699-731                 ..DSAPFKLLFMINTSILLSFIFIVLFIHFEGWRI..
A0A3Q0T2H1_AMPCI/715-747             ..DMTPFQALYILSSTVVILLLVTALTLRFHGWRI..
A0A2K5QK98_CEBCA/698-730             ..DSAPFELFFMISTSILSIFIFMVLLIHFEGWRI..
A0A2Y9FMG0_PHYMC/781-813             ..DSAPFELLFMINTSILLIFNLIVLLIHFEGWKI..
A0A2K5CME7_AOTNA/698-730             ..DSAPFELFFTISTSILLIFIFIVLLIHFEGWRI..
H3ATI5_LATCH/558-589                 .c--APFIILFKISTSFILIFLFAVVFIQFQGWRI..
A0A1S3W4P8_ERIEU/707-739             ..DSAPFELLFMINTSFLLIFIFNVLLIHFEGWRI..
A0A1U7QIC2_MESAU/699-731             ..DSAPFELLFMINTTVLLVFILMSLLIHFEGWRI..
A0A2K6TZX6_SAIBB/698-730             ..DSAPFELFFIISTSILLIFIFMVLVIHFEGWRI..
G3SGL1_GORGO/698-730                 ..DSAPFELFFMINTSILLIFIFIVLLIHFEGWRI..
A0A093IPK7_DRYPU/692-724             ..DSAPFKLMFVITTAAVMLLIFIVLSIHFEGWRI..
A0A3Q2CY54_CYPVA/705-737             ..DMTPFQVLYILTSTAVLLLMCSAFIYRFHGWRI..
TLR3_HUMAN/698-730                   ..DSAPFELFFMINTSILLIFIFIVLLIHFEGWRI..
#=GR TLR3_HUMAN/698-730        SS    ..--HHHHHHHHHHHHHHHHHHHHHHHHHHHH---..
A0A2Y9FLX4_PHYMC/699-731             ..DSAPFELLFMINTSILLIFNLIVLLIHFEGWKI..
A0A218VFJ9_9PASE/689-721             ..DSAPFKLLFVISTTIVMLFIFIVLTIHFEGWRI..
A0A2K6K9A3_RHIBE/698-729             ..DSAPFE-LFMISTSILLIFIFVVLLIHFEGWRI..
B8JIL3_DANRE/698-730                 ..DMTPFKALYILSSTAVLMLLFISFLVHFQGWRI..
E2RIV9_CANLF/699-731                 ..DSAPFEIFFIINTSVLLTFIFIVLLIHFEGWRI..
A0A3P9AIV7_ESOLU/705-737             ..DMTPFQALYVLTTTAVLILMVTSFLVRFHGWRI..
Q00L02_ICTPU/698-730                 ..DLVPFQALYVITSSLVLGLMVLAFLVHFQGWRI..
A0A3Q0T2H8_AMPCI/715-747             ..DMTPFQALYILSSTVVILLLVTALTLRFHGWRI..
A0A1L4FLT3_CHICK/689-721             ..DSAPFKLLFLITTTAVMQFMFIVLLIHFEGWRI..
A0A1B0GS40_MOUSE/175-207             ..DSAPFELLFIISTSMLLVFILVVLLIHIEGWRI..
A0A3Q3E9V8_9LABR/715-747             ..DMTPFQALYILSSTAVLMLMVTALLVRFHGWRI..
A0A3M0KLV2_HIRRU/689-721             ..DSAPFKLLFVISATIVTLLIFIVLTIHFEGWRI..
G1RKY9_NOMLE/698-730                 ..DSAPFELFFMINTSILLIFIFIVLLIHFEGWRI..
G5BNV5_HETGA/699-731                 ..DSAPFELFFVISTSLLLSFIFIVLLIHFEGWRI..
A0A3B3W012_9TELE/707-739             ..DMAPFQAFYVLNSTIVLMLILTALIYRFHGWRI..
M4AWR4_XIPMA/707-739                 ..DMAPFQAFYVLNSTAVLMLILTALIYRFHGWRI..
M1ZMQ4_SALSA/707-739                 ..DMTPFQALYVLTSTAVLTLMVTSLLVRFQGWRI..
A0A3B3ZRL9_9GOBI/707-739             ..DTTPFQALYILSSTTVLLLMVTALVVRFQGWRI..
D2HM22_AILME/699-731                 ..DSAPFELFFIINTSVSLIFIFIVLLIHFEGWRI..
A0A3Q7TAC3_VULVU/568-600             ..DSAPFEIFFIINTSVLLTFIFIVLLIHFEGWRI..
A0A087XJ58_POEFO/710-742             ..DMAPFQAFYVLNSTIVLMLILTALIYRFHGWRI..
S4R995_PETMA/707-739                 ..DHAPFFVMYVVSQSALLSVVVVALFVHFQGWRL..
I3JV98_ORENI/706-738                 ..DMTPFQTLYIVSSTAVIMLIVTALTVRFHGWRI..
A0A3Q7TW86_VULVU/699-731             ..DSAPFEIFFIINTSVLLTFIFIVLLIHFEGWRI..
A0A452RKA0_URSAM/699-731             ..DSAPFELFFIINTSVSLIFIFIVLLIHFEGWRI..
H2SIG4_TAKRU/684-716                 ..DMTPFRALYVVSSTTVILLLTVALFMRFHGWRI..
A0A2Y9J4G3_ENHLU/699-731             ..DSAPFELFFIINTSVSLIFIFIVLLIHFEGWRI..
#=GC SS_cons                         ..--HHHHHHHHHHHHHHHHHHHHHHHHHHHH---..
#=GC seq_cons                        ..DoAPFchLallooohlLlhIhhsLLlHFcGWRI..
//
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