GenomeNet

Database: Pfam
Entry: Tom37_C
LinkDB: Tom37_C
Original site: Tom37_C 
#=GF ID   Tom37_C
#=GF AC   PF11801.9
#=GF DE   Tom37 C-terminal domain
#=GF AU   Wood V;0000-0001-6330-7526
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Pfam-B_30563 (release 22.0)
#=GF GA   22.50 22.50;
#=GF TC   23.10 24.00;
#=GF NC   21.80 22.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16890951
#=GF RT   TOM20 and the heartbreakers: evidence for the role of
#=GF RT   mitochondrial transport proteins in cardioprotection. 
#=GF RA   Bowers M, Ardehali H; 
#=GF RL   J Mol Cell Cardiol. 2006;41:406-409.
#=GF RN   [2]
#=GF RM   17981999
#=GF RT   Functional definition of outer membrane proteins involved in
#=GF RT   preprotein import into mitochondria. 
#=GF RA   Lister R, Carrie C, Duncan O, Ho LH, Howell KA, Murcha MW,
#=GF RA   Whelan J; 
#=GF RL   Plant Cell. 2007;19:3739-3759.
#=GF DR   INTERPRO; IPR031317;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The TOM37 protein is one of the outer membrane proteins that
#=GF CC   make up the TOM complex for guiding cytosolic mitochondrial
#=GF CC   beta-barrel proteins from the cytosol across the outer
#=GF CC   mitochondrial membrane into the intra-membrane space. In
#=GF CC   conjunction with TOM70 it guides peptides without an MTS into
#=GF CC   TOM40, the protein that forms the passage through the outer
#=GF CC   membrane [1]. It has homology with Metaxin-1, also part of the
#=GF CC   outer mitochondrial membrane beta-barrel protein transport
#=GF CC   complex [2].
#=GF SQ   32
#=GS A7TPA1_VANPO/169-314      AC A7TPA1.1
#=GS SAM37_YEAST/179-326       AC P50110.1
#=GS J7SB06_NAUDC/185-351      AC J7SB06.1
#=GS Q6FU46_CANGA/157-300      AC Q6FU46.1
#=GS C5DCN1_LACTC/147-292      AC C5DCN1.1
#=GS A0A1G4J7E7_9SACH/149-293  AC A0A1G4J7E7.1
#=GS W0TH88_KLUMD/163-307      AC W0TH88.1
#=GS H2AM74_KAZAF/151-302      AC H2AM74.1
#=GS A0A1X7RA97_9SACH/175-321  AC A0A1X7RA97.1
#=GS A0A1E3P7V3_WICAA/155-305  AC A0A1E3P7V3.1
#=GS A0A0X8HSX8_9SACH/147-293  AC A0A0X8HSX8.1
#=GS I2H835_TETBL/161-303      AC I2H835.1
#=GS M3IWA9_CANMX/86-254       AC M3IWA9.1
#=GS A5DPS2_PICGU/167-322      AC A5DPS2.2
#=GS A0A1E4RUE2_CYBJN/156-312  AC A0A1E4RUE2.1
#=GS G8ZQF4_TORDC/164-308      AC G8ZQF4.1
#=GS A0A1V2L0K7_CYBFA/131-283  AC A0A1V2L0K7.1
#=GS Q6CII7_KLULA/155-300      AC Q6CII7.1
#=GS A0A0C7N499_9SACH/149-304  AC A0A0C7N499.1
#=GS Q759Y7_ASHGO/133-281      AC Q759Y7.1
#=GS C5E3Y6_ZYGRC/159-306      AC C5E3Y6.1
#=GS A0A1E4SF29_9ASCO/172-328  AC A0A1E4SF29.1
#=GS G8C1B5_TETPH/170-319      AC G8C1B5.1
#=GS A0A1G4JYW4_9SACH/148-293  AC A0A1G4JYW4.1
#=GS A0A1G4JIC5_9SACH/147-290  AC A0A1G4JIC5.1
#=GS G8JRZ0_ERECY/177-325      AC G8JRZ0.1
#=GS J5PJF5_SACK1/175-322      AC J5PJF5.1
#=GS G3BDQ0_CANTC/172-307      AC G3BDQ0.1
#=GS S6EZT7_ZYGB2/164-309      AC S6EZT7.1
#=GS J7RT35_KAZNA/175-324      AC J7RT35.1
#=GS A0A1G4MJ59_LACFM/146-289  AC A0A1G4MJ59.1
#=GS G0V7C7_NAUCC/174-317      AC G0V7C7.1
A7TPA1_VANPO/169-314                 ............................dy--LDEK....DDLEDVAADMAQ.SKTFKIKNKLKQRKREELKAIGYNLQFNNRLVELLKMWDTVRGN............L..NTEIEITS..DLLFWANMYILF..N..LPTGNNIKTHI..TKSLGESYIDMLNDKISLVS.............TKSN-YKVT.IRDPNFNEQGNIIMTLYNFSKYY....................
SAM37_YEAST/179-326                  ........................eddeef--VE--....SKAMESASQLAQ.SKTFKIAHKNKIKGKQELQQVKYNLQFDNRLQSCVSNWLAARKK............L..DDSVILSS..DLLFLANLYVQL..G..LPDGNRIRSKL..EQTFGSELLNSMSNKIDDFV.............HRPS-NNLE.QRDPQFREQGNVVMSLYNLACKY....................
J7SB06_NAUDC/185-351                 .........................emegf-----EnihiDEKHEHDPSMAH.SKTFKLTKYKKMQNKKTLQNLQDDMNYNKRFVEVLNDWFEVAKDv.........psI.yDGEGSCSSptYLLLLANLYIQM..E..LPNGSKIKEYL..---SSVEHWDKISNDLEYLKtsgygemiiqkdgSIDRNGGLQ.LQPAKFNEQGNIITSLYNYITWY....................
Q6FU46_CANGA/157-300                 ...........................eek--EDED....EDDGPADYELAQ.SKTFALRGLRKRQRAEELKSVRLNRNYMHKLLEFLDQWDSITDD............L..--PKTSPV..PILFYSYMYIQL..V.iLPNNNEICKYL..KEMKSNGYVDTLKETFTKYN.............ALDF--NLN.VREPVFRERGDLISTLLNKIS--v...................
C5DCN1_LACTC/147-292                 ......................hdddpeqv------....EQPNAELDGLVQ.SKAFKLTNASKARGEELLKSARYNLQYMSRLNRHVVSWREARAR............L..-DKDSTAA..DFLLWANLFVQM..E..LPDGQLVKEQL..QTALGPEDYESIIKRLNDCS.............KSTS--TLE.LRGPFFAEKGNVVMSAYHALQ--rl..................
A0A1G4J7E7_9SACH/149-293             ........................ddadha------....EFDADQVDDLVQ.SKAFKLTQASKARKADMLKSARFNLQYMSRLGDQIQSWLDAREK............L..GSTQPIAA..DYLVWANLFVQL..E..LPDGNLVREHL..QHALGDNRYRELTANLQRCS.............LLDS--HLP.YREAVFNERGNLLMSAYHAV---grl.................
W0TH88_KLUMD/163-307                 ........................ldsgak---GSQ....NSHQDKAIEMAQ.SQVFKVARDNKKQQKKRLQDLKNNSRVISNLTQILTHWTTARPA............V..-DAKLIPA..DLLLAAHLKVQM..D..LPQGDIVNTHL..-----LNNFPTLYSTVKEIQ.............QRNSDLQIPnIRDPSFTESGNVVMSTFNLIKTY....................
H2AM74_KAZAF/151-302                 ...........................dne--EESD....KQEDIEEEDLTQ.SKTFKLQKVKRKAQKEQLTDLKNNLKFRERSSSLLKEWKEMRYSe.........alL.sDRSRKIPA..DYLLYANLYIQL..N..LPDGKQIREAM..KLKLESSFCNKIESELNHYN.............KLADENSLK.FRAPTFAEQSNVATSLYYLAKMY....................
A0A1X7RA97_9SACH/175-321             ...........................dyv---SDE....ETSMKEAANVAQ.SRTFKLKAKSLIRNKNELFETKHNLQYLNKMVDILKDWFSIRYM............VlpREHTPIAA..DILLWANIYVQV..S..LPEGTKVLDRI..KEDLGQEQANNIMEMIHKLS.............TKSA--VLK.ERHPTFQEQGNAVMSLYHK----gvsf................
A0A1E3P7V3_WICAA/155-305             ........................tiedkt------....EIEQEMLKNVPTvSKVQQLKHESMIEDKLVLKNSVSNMKCLNYYQNLIETIIKMQKElgnd....akinI..FGDQITTC..DLILVAHLYIQT..HqsLPDQF-ITNYL..-INLSPGFLETKTSNLSKIE.............LKLS--KIK.IESPLFKDSPNLLNSI-------ryll................
A0A0X8HSX8_9SACH/147-293             .......................dtrdeqv------....GPVDEATKHLARdSKTFQMTQERRQKDKEMLEYTKYNMQYTSQLQEVLKSLLDARKN............I..-PDQLIPA..DLLLYANLYVQL..E..LPDGERIQTFL..-QHQFPDFMRSLLETCNKYS.............HLAVAGNVI.LREPTFSESGNLLMTTYNFTR--ni..................
I2H835_TETBL/161-303                 ..........................ncda--DDS-....-DDGDLPPGLIQ.SKTFKMNQDKRKKSKHQLRESSNQLQMTHILKDILNEYQAMRKI............V..-PGESIPV..DLYYLAHLYILV..Q..LPDHNDTSQII..-QQYHYQDYCTLDKYIQTFS.............STKS--TIT.IREPHFTELGNVAMSLYRRVP--yl..................
M3IWA9_CANMX/86-254                  eqqeeevaqteifndeisddededgkvaai------....------------.SSLHEKQLLKKSKTKQVLQESKNSMRCLILINNYINEIVKLYKErnpds.gkefgfI..FGDNSVPSssEVLFYAYIYCLT..NdvLPDR-FIYNYL..-HQKRGTIVEFIDNVTNDFN.............DTIDEESI-.-RDPIDDEIPNLINEV-------kiwanw..............
A5DPS2_PICGU/167-322                 ........................gssgph------....DEVDEETSEVAL.SALHERQMTAKSNKRELLRQSKNSLKCLNYLGEILDDIVKLNHQlnphrpddtfalI.fNESKISVA..ELLLFAYIHSLT..YdgLPDHA-IHDYI..-RLKYSSFADFSQTKINELN.............QLLDDSAI-.-QPPNSSQVPNLINEV-------ryrlg...............
A0A1E4RUE2_CYBJN/156-312             ..........................kved----KS....QVTEEMMKNVPSvSKIHRMKYESMIEDKLLMKNSVTNMSCLRQLNEYVGRVLELQAElnanh.egdtlgL.fGENRLTSG..DLIILAHIYVWT..RaaLPDQ-FIKTFL..-DKSYPHISTQLEHLLQERI.............NPAT-DHVQ.IRLPSFTESPNLFNSIKHL----vi..................
G8ZQF4_TORDC/164-308                 ........................seeeea------....LSGSTEPSELAQ.SKTFKVTQQNKRKGKEELQNAKFNMQYLNKLSEHLKVWIQVRER............A..MSEKVIPA..DLLMWANIYVQL..Q..LPDKDKVATHL..SQTLGSDFFATLQKQLDLCS.............HFEP--IIP.FREPTFQEQGNAIMSIYNKGAKY....................
A0A1V2L0K7_CYBFA/131-283             ...........................kve---DKT....DVEEEMLKNVPTvSKVQQLKHDNMIEEKLVLKNSVTNMKCINQLQESIRVINQLQLElgsh....pvdnI.fSTTTMTSS..DLLLLAHLYIIT..HkdLPDQ-FIRSFL..-QRTSPEILARVDQNLKVVQ.............DAIS--KIQ.RRGPTFWESPNIVNAVRHL----vv..................
Q6CII7_KLULA/155-300                 ........................deenes-----TsnhqDELSEKATELAQ.SKVFKITRDSKRQQTKKLQELKNNSRFTTKLDNVLTNWESARQS............L..-ASAVLPA..DLVLVAHLKVQM..A..LPQGDLLRSHL..-----RNQYPSLYDKVNELI.............EKYDNSPVP.NRDPTFSESGNVVTSTCYFLRT-f...................
A0A0C7N499_9SACH/149-304             .....................ddadhveel------....--GEDDIDDMVQ.SKAYKLTKASKARNQELLKSARFNLQFLNRLSDQLQSWFEARDKmrss....ssssT..AATQIVPA..DFLLWANLLIQL..E..LPDGHLVREHL..NRALGSEKVTEIESECKRRS.............EYQNKIRVN.LRDPSFSERGNAVMSAYYSLC--rl..................
Q759Y7_ASHGO/133-281                 ....................raraqrggtp------....APAHDAEKELAQhSKTLQATRELRERGEKALADAAAEMEYAAALDRALQPWIAVRGA............-..-AATLGPA..ELLFAAHLYVQQ..Q..LPDGARVTAHL..-RAHYPALCDGLLRACELHA.............CAPRAAAVA.VRAPTAAETPSVPRELYRYVTSY....................
C5E3Y6_ZYGRC/159-306                 ......................hdddpdsl------....ESLELESTRLPQ.SKAFQATQDRKMRSKEELQNVKHNLQYLTRLKDYLRTWSQVRNS............I.pHQNDTIPA..DFLLWANLFVQL..N..LPDGEKVGQQV..KDAVNDDFHQLVQSKIDQLS.............SLEP--RVF.QRDPIFQEQGNVIMSIYHYVHKF....................
A0A1E4SF29_9ASCO/172-328             ...................elaqteyindd------....---ADEPDQVAI.STLHERQLITKSKEKMALKESKNSLRCLVLINEYLQHYIRIFAKrnaed.gsdfgpI.fDTTKFSSS..ELLLYAYIYSLTfeE..LPDT-FLQNYL..-HLKHPEVLDFIKVQIGTFN.............KILY-SGEK.IRGPVADEVPSL-----------wneikyls............
G8C1B5_TETPH/170-319                 ............................ie-EVDAK....--QSEAVENMAQ.SKTFAIKNAAARKQREELQNIKHNATFLYRVNAVYKKYTEISSQ............L.kNSDSMHTSvvKLLFLANVFIWS..Q..LPNYKEIKTHLlkDVDVDKNEYEKLFDKIESLN.............SGTK-SGIT.IRKPYFKEQCNIIMTLYNYIASY....................
A0A1G4JYW4_9SACH/148-293             .......................addedhf------....EFDAEQIDELVQ.SKAFKLTKASKARKEDLLKSARFNLQYMNRLGDQIKCWLEAREK............L..EPQPVLAS..DYLVWANLFVQL..E..LPDGNLVREHL..QRTLGKDKYEVLAANLENCS.............QSTS--RLY.QRGPTFEERGNVVMSAYQAMC--rl..................
A0A1G4JIC5_9SACH/147-290             ...........................hpd---DEE....SDENVAVEEMTQ.SSVLKLSSRAKSRGRELLADTRHSVQYLSELGEQLKTWLEARGR............L..-NKEVIAA..DFLLWANLHVQL..T..LPRGQRIGDYL..HEFLGAEAYQEIQEQLRRCD.............KLAC--SLD.QRPPNFAENGNPLMSTYAAVQK-v...................
G8JRZ0_ERECY/177-325                 ....................essddanign------....SITDQAEKELARsSKAFRNIEKQHEKNQQTLNYVKYSMQYMSKLDSSLTPWIEARKE............I..-GKELNVL..DILLYAHIYVQM..I..LPDGARIKEHL..-KKTFPEFFTMLMSTCDICS.............SRKA-DKVT.IRDPTFLESGNIPMTVYRSITSF....................
J5PJF5_SACK1/175-322                 .......................eddedfv---E--....SKALESASQLAQ.SKTFKITHENNVKNKQDLQQVKYNLQFDNRLKTCIKHCLQVRKK............L..DESVVLPP..DILFYANIYVQL..S..LPDGNRVRSKL..EQTFGGEFVNNTLNKIGEFV.............QSSD-NDLE.QRDPRFKEQGNVVMSLYNLACKY....................
G3BDQ0_CANTC/172-307                 .....................dnapvddle------....------DDTMTPiSKLHEKQMMLKNKERMSLRETKNTLKSIALLDGYLSQWEAS--S............I.gNSSQITAA..EVLFLAYLSCIF..HeeLPDSSLTTT-M..--KTHQNLYEWAENWTQTLE.............KLADY----.-----------------------kdivppvgsqipnlyneiky
S6EZT7_ZYGB2/164-309                 .......................dddpdkl------....DDFNIDSANLAQ.SKTFKVSQARKMRSKEELQNAKHNVQFLEELTRHLEIWIQIREH............I..KSDKVITA..DLLMWANVYVQL..N..LPEGDRIGKHI..ASKLGDDFLQTLKVQLKVCS.............SLET--KVP.QRDPTFQEQGNVIMSLCNRVQKF....................
J7RT35_KAZNA/175-324                 ...................eddledtpsel------....QGAMEQPEQLTQ.SKTFRLKQSQNMRRKEELSAKKLELQFFHKLIEVLHHSQVLEDE............L..HTDFEFAY..TNLLQAYVYVLV..N..LPDGDSTRARI..EREFGSEYLQGIEHAIDLKN.............NGAG--LLK.IREAQFQEQGNIIMSVYHKARQ-t...................
A0A1G4MJ59_LACFM/146-289             ............................sh--EDDE....EEHSVEYDDLVQ.SKAIKVTQNSKVENKELLKSTRYNMQFLNRLGEQLKWWLEARKK............V..-PKDKIPA..DYLLWANLFVQQ..E..LPDGRVVREFL..EQNLGSDAYRNIQEHLHECT.............QLES--VVA.IRQPTFTESGNIVTSVYRQAI--ry..................
G0V7C7_NAUCC/174-317                 ..........................rdne-EDEDG....TMGESLGAGLAQ.SKPFKLQQRRQQMNKEQLQELKNNTRYFHKLDKFLTEWFAMRKN............L..AGDDVDAI..MVLFLAHLNVQL..E..LPEGDKVKDIL..ETKFADE-WEWLQPHLGAMK.............RLPN--VVR.VRPAVFREQGNMVMSLYNV----l...................
#=GC seq_cons                        ...........................pph..........p.tpctspplsQ.SKsF+lpppp+t+p+ctLpss+hNhpahscLschLppWhphRpp............l...ssphhsu..DlLlhAplalQh..p..LPDGphlpsaL...pphssphhpplpsplpphs.............phts..plt.hRsPsFpEpGNllhSlYphht......................
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