GenomeNet

Database: Pfam
Entry: Tower
LinkDB: Tower
Original site: Tower 
#=GF ID   Tower
#=GF AC   PF09121.11
#=GF DE   Tower
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1mje
#=GF GA   25.00 25.00;
#=GF TC   26.00 26.80;
#=GF NC   24.30 24.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   BRCA2
#=GF RN   [1]
#=GF RM   12228710
#=GF RT   BRCA2 function in DNA binding and recombination from a
#=GF RT   BRCA2-DSS1-ssDNA structure. 
#=GF RA   Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng
#=GF RA   N, Chen PL, Lee WH, Pavletich NP; 
#=GF RL   Science 2002;297:1837-1848.
#=GF DR   INTERPRO; IPR015205;
#=GF DR   SCOP; 1mje; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Members of this family adopt a secondary structure consisting of
#=GF CC   a pair of long, antiparallel alpha-helices (the stem) that
#=GF CC   support a three-helix bundle (3HB) at their end. The 3HB
#=GF CC   contains a helix-turn-helix motif and is similar to the DNA
#=GF CC   binding domains of the bacterial site-specific recombinases, and
#=GF CC   of eukaryotic Myb and homeodomain transcription factors. The
#=GF CC   Tower domain has an important role in the tumour suppressor
#=GF CC   function of BRCA2, and is essential for appropriate binding of
#=GF CC   BRCA2 to DNA [1].
#=GF SQ   187
#=GS BRCA2_HUMAN/2831-2872       AC P51587.3
#=GS A0A452FHU5_CAPHI/2818-2859  AC A0A452FHU5.1
#=GS K7EF63_ORNAN/1-42           AC K7EF63.1
#=GS L5KEV4_PTEAL/2869-2910      AC L5KEV4.1
#=GS F7B8V0_ORNAN/2832-2873      AC F7B8V0.2
#=GS A0A3B3R4E7_9TELE/2485-2526  AC A0A3B3R4E7.1
#=GS A0A087X722_POEFO/2537-2578  AC A0A087X722.2
#=GS A0A1A6GQQ1_NEOLE/2595-2636  AC A0A1A6GQQ1.1
#=GS A0A2K6F2Q1_PROCO/2838-2879  AC A0A2K6F2Q1.1
#=GS A0A0Q3M8S4_AMAAE/2636-2677  AC A0A0Q3M8S4.1
#=GS F1Q0X3_CANLF/2850-2891      AC F1Q0X3.1
#=GS A0A452FIX7_CAPHI/2758-2799  AC A0A452FIX7.1
#=GS G1NQB1_MELGA/2775-2816      AC G1NQB1.1
#=GS BRCA2_RAT/2761-2802         AC O35923.1
#=GS BRCA2_RAT/2761-2802         DR PDB; 1IYJ D; 2761-2784;
#=GS BRCA2_RAT/2761-2802         DR PDB; 1IYJ B; 2761-2784;
#=GS H3DFR1_TETNG/600-641        AC H3DFR1.1
#=GS A0A1V4K9H1_PATFA/2821-2862  AC A0A1V4K9H1.1
#=GS A0A3M0K236_HIRRU/2659-2700  AC A0A3M0K236.1
#=GS G3SGJ0_GORGO/2830-2871      AC G3SGJ0.2
#=GS A0A2G8LLE5_STIJA/535-576    AC A0A2G8LLE5.1
#=GS A0A3Q3LZH7_9TELE/2383-2424  AC A0A3Q3LZH7.1
#=GS G3HM86_CRIGR/2780-2821      AC G3HM86.1
#=GS A0A2P8YPU6_BLAGE/898-939    AC A0A2P8YPU6.1
#=GS A0A151MPE0_ALLMI/569-610    AC A0A151MPE0.1
#=GS A0A3B1J8R5_ASTMX/2106-2147  AC A0A3B1J8R5.1
#=GS A0A401P8K5_SCYTO/2660-2701  AC A0A401P8K5.1
#=GS A0A3B4UCS1_SERDU/2546-2587  AC A0A3B4UCS1.1
#=GS W4YCF6_STRPU/2982-3023      AC W4YCF6.1
#=GS A0A091EHE3_CORBR/2793-2834  AC A0A091EHE3.1
#=GS I3LVC1_PIG/2641-2682        AC I3LVC1.2
#=GS F1P3B2_CHICK/2776-2817      AC F1P3B2.1
#=GS G1KCX8_ANOCA/679-720        AC G1KCX8.2
#=GS A0A3Q0R566_AMPCI/405-446    AC A0A3Q0R566.1
#=GS A0A452IW50_9SAUR/2965-3006  AC A0A452IW50.1
#=GS A0A3B3I014_ORYLA/2541-2582  AC A0A3B3I014.1
#=GS A0A2K5ZBS6_MANLE/3089-3130  AC A0A2K5ZBS6.1
#=GS A0A096MSF7_PAPAN/2835-2876  AC A0A096MSF7.2
#=GS A0A2U4BGI3_TURTR/2837-2878  AC A0A2U4BGI3.1
#=GS A0A2K5RU73_CEBCA/2486-2527  AC A0A2K5RU73.1
#=GS F1R8E8_DANRE/2376-2417      AC F1R8E8.1
#=GS A0A3Q2CW94_CYPVA/1807-1848  AC A0A3Q2CW94.1
#=GS A0A2U3XC46_LEPWE/2221-2262  AC A0A2U3XC46.1
#=GS G3PC75_GASAC/343-384        AC G3PC75.1
#=GS A0A3Q7RZM0_VULVU/2849-2890  AC A0A3Q7RZM0.1
#=GS A0A2Y9RLS4_TRIMA/537-578    AC A0A2Y9RLS4.1
#=GS A0A2K6QQ81_RHIRO/2833-2874  AC A0A2K6QQ81.1
#=GS A0A1S2ZJK9_ERIEU/2766-2807  AC A0A1S2ZJK9.1
#=GS A0A2I0MCT6_COLLI/2802-2843  AC A0A2I0MCT6.1
#=GS A0A2Y9KYL6_ENHLU/2859-2900  AC A0A2Y9KYL6.1
#=GS G3W9Q7_SARHA/2790-2831      AC G3W9Q7.1
#=GS I3LFN0_PIG/2624-2665        AC I3LFN0.2
#=GS A0A2K5RU94_CEBCA/2538-2579  AC A0A2K5RU94.1
#=GS H2NJK5_PONAB/2828-2869      AC H2NJK5.1
#=GS Q66MH4_RAT/2761-2802        AC Q66MH4.1
#=GS A0A2D0SX90_ICTPU/2134-2175  AC A0A2D0SX90.1
#=GS A0A3Q0DCY9_MESAU/2553-2594  AC A0A3Q0DCY9.1
#=GS W5L0S8_ASTMX/1983-2024      AC W5L0S8.2
#=GS A0A401S853_CHIPU/2819-2860  AC A0A401S853.1
#=GS W4Z4A8_STRPU/147-188        AC W4Z4A8.1
#=GS A0A060Y4H5_ONCMY/1843-1884  AC A0A060Y4H5.1
#=GS A0A452RG86_URSAM/2782-2823  AC A0A452RG86.1
#=GS A0A3Q1IDS8_ANATE/1469-1510  AC A0A3Q1IDS8.1
#=GS A0A3B3R6U5_9TELE/2445-2486  AC A0A3B3R6U5.1
#=GS BRCA2_MOUSE/2752-2793       AC P97929.2
#=GS BRCA2_MOUSE/2752-2793       DR PDB; 1MJE A; 2752-2792;
#=GS BRCA2_MOUSE/2752-2793       DR PDB; 1MIU A; 2752-2793;
#=GS F7BTV7_CALJA/2823-2864      AC F7BTV7.2
#=GS A0A384C7I9_URSMA/2853-2894  AC A0A384C7I9.1
#=GS A0A3Q0GXG7_ALLSI/2728-2769  AC A0A3Q0GXG7.1
#=GS G1QK32_NOMLE/2832-2873      AC G1QK32.1
#=GS A0A1S3JJD8_LINUN/3535-3576  AC A0A1S3JJD8.1
#=GS A0A3B3B7M7_ORYME/2403-2444  AC A0A3B3B7M7.1
#=GS F7ER68_MACMU/2835-2876      AC F7ER68.2
#=GS A0A3B3VP71_9TELE/2537-2578  AC A0A3B3VP71.1
#=GS A0A0L8GLI0_OCTBM/1742-1783  AC A0A0L8GLI0.1
#=GS A0A091INQ8_EGRGA/2785-2826  AC A0A091INQ8.1
#=GS A0A402EBG8_9SAUR/2667-2708  AC A0A402EBG8.1
#=GS A0A2U3WDR6_ODORO/2848-2889  AC A0A2U3WDR6.1
#=GS W5MNK3_LEPOC/357-398        AC W5MNK3.1
#=GS A0A1L8HIX3_XENLA/2648-2689  AC A0A1L8HIX3.1
#=GS A0A1U7U304_TARSY/2844-2885  AC A0A1U7U304.1
#=GS A7SNN6_NEMVE/309-350        AC A7SNN6.1
#=GS A0A3Q7WEX9_URSAR/2866-2907  AC A0A3Q7WEX9.1
#=GS K1RH48_CRAGI/2166-2207      AC K1RH48.1
#=GS A0A2I3RQQ1_PANTR/2799-2840  AC A0A2I3RQQ1.1
#=GS A0A1S3SX37_SALSA/2330-2371  AC A0A1S3SX37.1
#=GS J9K360_ACYPI/1050-1091      AC J9K360.2
#=GS G1LS71_AILME/2863-2904      AC G1LS71.1
#=GS A0A340XSP0_LIPVE/2839-2880  AC A0A340XSP0.1
#=GS A0A3Q0GSV1_ALLSI/2711-2752  AC A0A3Q0GSV1.1
#=GS A0A452C3D5_BALAS/2745-2786  AC A0A452C3D5.1
#=GS A0A2I4BP92_9TELE/2506-2547  AC A0A2I4BP92.1
#=GS F7E9I9_XENTR/2600-2641      AC F7E9I9.1
#=GS W5PNG4_SHEEP/2800-2841      AC W5PNG4.1
#=GS A0A3P8XPR1_ESOLU/2319-2360  AC A0A3P8XPR1.1
#=GS A0A1S3SX34_SALSA/2318-2359  AC A0A1S3SX34.1
#=GS G5E764_LOXAF/2767-2808      AC G5E764.1
#=GS A0A2U9B4U4_SCOMX/2241-2282  AC A0A2U9B4U4.1
#=GS A0A091IID7_CALAN/2792-2833  AC A0A091IID7.1
#=GS M3ZXN9_XIPMA/2555-2596      AC M3ZXN9.1
#=GS U3IJI9_ANAPP/2784-2825      AC U3IJI9.2
#=GS A0A3B3WDX8_9TELE/2184-2225  AC A0A3B3WDX8.1
#=GS A0A087QM77_APTFO/2817-2858  AC A0A087QM77.1
#=GS A0A3B4WQB3_SERLL/2238-2279  AC A0A3B4WQB3.1
#=GS A0A151MPQ2_ALLMI/428-469    AC A0A151MPQ2.1
#=GS W5MNL3_LEPOC/350-391        AC W5MNL3.1
#=GS H0ZNF4_TAEGU/2747-2788      AC H0ZNF4.1
#=GS H3AGP4_LATCH/592-633        AC H3AGP4.2
#=GS A0A3Q1LJN4_BOVIN/2564-2605  AC A0A3Q1LJN4.1
#=GS A0A091WEP0_OPIHO/2816-2857  AC A0A091WEP0.1
#=GS A0A1U8D5M6_ALLSI/2729-2770  AC A0A1U8D5M6.1
#=GS A0A091UQ74_NIPNI/2805-2846  AC A0A091UQ74.1
#=GS G5B7X6_HETGA/2694-2735      AC G5B7X6.1
#=GS A0A099ZWS6_TINGU/2823-2864  AC A0A099ZWS6.1
#=GS H0YD86_HUMAN/1-38           AC H0YD86.1
#=GS A0A3Q4IA78_NEOBR/1895-1936  AC A0A3Q4IA78.1
#=GS K7JTG8_NASVI/1629-1668      AC K7JTG8.1
#=GS G1PNI9_MYOLU/2780-2821      AC G1PNI9.1
#=GS L9JDB5_TUPCH/2707-2748      AC L9JDB5.1
#=GS M3XS78_MUSPF/2857-2898      AC M3XS78.1
#=GS A0A1S3SX55_SALSA/2328-2369  AC A0A1S3SX55.1
#=GS A0A3Q1AWU5_AMPOC/2461-2502  AC A0A3Q1AWU5.1
#=GS A0A091DSV6_FUKDA/2771-2812  AC A0A091DSV6.1
#=GS F6XH22_MONDO/2817-2858      AC F6XH22.2
#=GS A0A2K5RU61_CEBCA/2538-2579  AC A0A2K5RU61.1
#=GS A0A2Y9EMN5_PHYMC/2827-2868  AC A0A2Y9EMN5.1
#=GS A0A093KA59_STRCA/2822-2863  AC A0A093KA59.1
#=GS A0A1V4K9L4_PATFA/2841-2882  AC A0A1V4K9L4.1
#=GS A0A2K6CN06_MACNE/2835-2876  AC A0A2K6CN06.1
#=GS A0A1S3SX28_SALSA/2334-2375  AC A0A1S3SX28.1
#=GS A0A3Q3FAJ5_KRYMA/2172-2213  AC A0A3Q3FAJ5.1
#=GS H0X313_OTOGA/2820-2861      AC H0X313.1
#=GS I3JDK0_ORENI/2327-2368      AC I3JDK0.1
#=GS A0A2K5VXA2_MACFA/2833-2874  AC A0A2K5VXA2.1
#=GS A0A3M6TPC3_9CNID/1907-1948  AC A0A3M6TPC3.1
#=GS H3C2G7_TETNG/602-643        AC H3C2G7.1
#=GS A0A452RG22_URSAM/2861-2902  AC A0A452RG22.1
#=GS A0A2B4S5I5_STYPI/1882-1923  AC A0A2B4S5I5.1
#=GS A0A0D9RZ99_CHLSB/2834-2875  AC A0A0D9RZ99.1
#=GS A0A226MS07_CALSU/2326-2367  AC A0A226MS07.1
#=GS M7BD34_CHEMY/2726-2767      AC M7BD34.1
#=GS F6RE00_XENTR/2624-2665      AC F6RE00.1
#=GS A0A2R8ZDX5_PANPA/2830-2871  AC A0A2R8ZDX5.1
#=GS A0A1V4K9E8_PATFA/2897-2938  AC A0A1V4K9E8.1
#=GS A0A3Q3A225_KRYMA/2049-2090  AC A0A3Q3A225.1
#=GS G3SQY0_LOXAF/2775-2816      AC G3SQY0.1
#=GS R0K5Y4_ANAPL/2763-2804      AC R0K5Y4.1
#=GS A0A2K5I125_COLAP/2832-2873  AC A0A2K5I125.1
#=GS A0A091GDB0_9AVES/2804-2845  AC A0A091GDB0.1
#=GS F7B8W7_ORNAN/2878-2919      AC F7B8W7.2
#=GS F6TTA8_HORSE/2845-2886      AC F6TTA8.2
#=GS A0A3P9P903_POERE/2539-2580  AC A0A3P9P903.1
#=GS H0V4T0_CAVPO/2554-2595      AC H0V4T0.2
#=GS K7FXU8_PELSI/2481-2522      AC K7FXU8.1
#=GS A0A498MF28_LABRO/1788-1829  AC A0A498MF28.1
#=GS E1B8X8_BOVIN/2829-2870      AC E1B8X8.3
#=GS H2SRJ3_TAKRU/2222-2263      AC H2SRJ3.2
#=GS BRCA2_FELCA/2775-2816       AC Q864S8.2
#=GS A0A287B8J8_PIG/2703-2744    AC A0A287B8J8.1
#=GS A0A218V6H1_9PASE/2661-2702  AC A0A218V6H1.1
#=GS A0A3B3I5Q9_ORYLA/2664-2705  AC A0A3B3I5Q9.1
#=GS A0A2K5RU98_CEBCA/2808-2849  AC A0A2K5RU98.1
#=GS A0A3Q2WAQ0_HAPBU/2804-2845  AC A0A3Q2WAQ0.1
#=GS W5PNG2_SHEEP/2829-2870      AC W5PNG2.1
#=GS A0A2K5LR30_CERAT/2834-2875  AC A0A2K5LR30.1
#=GS M3WZI6_FELCA/2778-2819      AC M3WZI6.3
#=GS H2Q7E2_PANTR/2831-2872      AC H2Q7E2.2
#=GS A0A3B4BU74_PYGNA/2253-2293  AC A0A3B4BU74.1
#=GS A0A232EKY0_9HYME/1627-1666  AC A0A232EKY0.1
#=GS A0A2T7NK66_POMCA/1590-1631  AC A0A2T7NK66.1
#=GS A0A2I3LGA1_PAPAN/2835-2876  AC A0A2I3LGA1.1
#=GS A0A2K5D388_AOTNA/2817-2858  AC A0A2K5D388.1
#=GS R7TCX8_CAPTE/163-204        AC R7TCX8.1
#=GS U3K1B7_FICAL/2793-2834      AC U3K1B7.1
#=GS A0A210QDY6_MIZYE/3673-3714  AC A0A210QDY6.1
#=GS A0A151MPT0_ALLMI/429-470    AC A0A151MPT0.1
#=GS A0A2Y9NLY0_DELLE/2837-2878  AC A0A2Y9NLY0.1
#=GS G3UEA2_LOXAF/638-679        AC G3UEA2.1
#=GS A0A096LY08_POEFO/2526-2567  AC A0A096LY08.1
#=GS A0A3Q3E6E1_9LABR/484-525    AC A0A3Q3E6E1.1
#=GS A0A3S0ZXR0_ELYCH/343-384    AC A0A3S0ZXR0.1
#=GS A0A3L8SUZ7_CHLGU/2765-2806  AC A0A3L8SUZ7.1
#=GS A0A3P9BYT6_9CICH/2804-2845  AC A0A3P9BYT6.1
#=GS A0A093S0V4_9PASS/2811-2852  AC A0A093S0V4.1
#=GS A0A0P7TGJ2_SCLFO/2050-2091  AC A0A0P7TGJ2.1
#=GS A0A1S3SX29_SALSA/2334-2375  AC A0A1S3SX29.1
#=GS G1TCK4_RABIT/2813-2854      AC G1TCK4.1
#=GS A0A4D9EIK0_9SAUR/2968-3009  AC A0A4D9EIK0.1
#=GS A0A2D0SXT8_ICTPU/2140-2181  AC A0A2D0SXT8.1
#=GS A0A287AWN0_PIG/2613-2654    AC A0A287AWN0.1
BRCA2_HUMAN/2831-2872                  MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEE....
A0A452FHU5_CAPHI/2818-2859             MEKTSTGLYIFRNEKEEEKEATKYAEAQQKKLEALFTKIQAE....
K7EF63_ORNAN/1-42                      MEKTHTGSYVFRNERAEEKEASKHAESQQKKLEALYAKIQD-d...
L5KEV4_PTEAL/2869-2910                 VEKTSSGLYIFRNEREEEKEAAKYAETQQRKLEALFTKIQAE....
F7B8V0_ORNAN/2832-2873                 MEKTHTGSYVFRNERAEEKEASKHAESQQKKLEALYAKIQD-d...
A0A3B3R4E7_9TELE/2485-2526             MEKKPDGAYVFRSGRAEEREVQRHSASKQKTMETLFAKIQAQ....
A0A087X722_POEFO/2537-2578             MERKSDGGVVFRSVRAEEKEARRFNSHKQKAVELLFAKVQAE....
A0A1A6GQQ1_NEOLE/2595-2636             VEKTASGLYIFRNEREEEKEAVRFAGAQQKKLEALFTKIQAE....
A0A2K6F2Q1_PROCO/2838-2879             MEKTSSGLYIFRNEREEEKEVAKYAEAQQKRLEALFTKIQAE....
A0A0Q3M8S4_AMAAE/2636-2677             MEKTSAGSYVFRNSRAEEREAAKHAEGQQKKLEALFAKIQAE....
F1Q0X3_CANLF/2850-2891                 MERTPSGLCIFRNEREEEKEATKYAEIQQKKLEVLFNKIQAE....
A0A452FIX7_CAPHI/2758-2799             MEKTSTGLYIFRNEKEEEKEATKYAEAQQKKLEALFTKIQAE....
G1NQB1_MELGA/2775-2816                 MEKTSAGSYVFRNSRAEEREAAKHAEDQQKKLEALFAKIQAE....
BRCA2_RAT/2761-2802                    VEKTVSGSYIFRNEREEEKEALRFAEAQQKKLEALFTKVHTE....
#=GR BRCA2_RAT/2761-2802         SS    EEE-SSSSEEEE-HHHHHHHHH--XXXXXXXXXXXXXXXXXX....
H3DFR1_TETNG/600-641                   MERKPEGGTVFRSGRAEEKEARRYNVHKEKAMEILFDKIQAE....
A0A1V4K9H1_PATFA/2821-2862             MEKTSAGSYVFRNNRAEEREAAKHAEDQQKKLEALFAKIQAE....
A0A3M0K236_HIRRU/2659-2700             MEKTSTGSYIFRNSRAEEREAAKHAEDQQKKLEALFAKIQAE....
G3SGJ0_GORGO/2830-2871                 MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEE....
A0A2G8LLE5_STIJA/535-576               MEKYPDGSSVFRSLRAEERAAAEFLKTKQRKMEIIYSQIQK-k...
A0A3Q3LZH7_9TELE/2383-2424             MERKPDGGIVFRSIRAEEKEARRYNSHKQKAIEILFAKIQAE....
G3HM86_CRIGR/2780-2821                 VEKTASGLYIFRNEREEEKEAVRFAAAQQKKLEALFTKIQAE....
A0A2P8YPU6_BLAGE/898-939               VEKLEEGKSIFRSARVEEQVAARWERQRQACVEDVYSQIRKE....
A0A151MPE0_ALLMI/569-610               MEKKPTGSYVFRNNRAEEREAAKHAENQQKHLEALFAKIQAE....
A0A3B1J8R5_ASTMX/2106-2147             MEKRTGGVFVFRNERAEDREARRHSSAKQKTMELLFTRIQAQ....
A0A401P8K5_SCYTO/2660-2701             MEKKSKGMYVFRNERAEEREARIHYENQQQKLEALYAKIET-r...
A0A3B4UCS1_SERDU/2546-2587             MQRKPDGGVVFRSVRAEEKEARRYSSHKQKAMEILFAKIQTE....
W4YCF6_STRPU/2982-3023                 MEKLPEGGSVFRNAKEEAKAAALHAGRKQNKMEQLFTQIQKQ....
A0A091EHE3_CORBR/2793-2834             MEKTSAGSYVFRNSRAEEREAAKHAEDQQKKLETLFAKIQAE....
I3LVC1_PIG/2641-2682                   MEKTSSGLYIFRNEREEEKEATKYAEAQQKNLEALFTKIQAE....
F1P3B2_CHICK/2776-2817                 MEKTSAGSYVFRNSRAEEREAAKHAEDQQKKLEALFAKIQAE....
G1KCX8_ANOCA/679-720                   MEKTSTGSYMFRNCRAEEREAAKHAENKQKTLEALLANIQAE....
A0A3Q0R566_AMPCI/405-446               MERKPDGGVVFRSSRAEEKEARRYSSQKQKAMEILFAKIQAE....
A0A452IW50_9SAUR/2965-3006             VEKISAGSYVFRNGRAEEREAAKHAENRQKHLEALFSQIQVE....
A0A3B3I014_ORYLA/2541-2582             MERKADGGVVFRTTRAEEKEARRFDEMKHKAMEVLFAKVQAE....
A0A2K5ZBS6_MANLE/3089-3130             MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEE....
A0A096MSF7_PAPAN/2835-2876             MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEE....
A0A2U4BGI3_TURTR/2837-2878             MEKTSSGLYIFRNEREEEKEATKYAEAQQKKLEALFTKIQAE....
A0A2K5RU73_CEBCA/2486-2527             MEKTSSGLYIFRKEREEEKEAAKHAEAQQKRLEALFTKIQEE....
F1R8E8_DANRE/2376-2417                 MEKKPNSVFIFRNDRAEDREARKHSNSKHKSLDLLISKIQTQ....
A0A3Q2CW94_CYPVA/1807-1848             MERKSDGGVVFRSDRAEEKEARRFSHHKQKVMEMLFAKIQAE....
A0A2U3XC46_LEPWE/2221-2262             MERTLSGICVFRNEREEEKEATKYAEAQQKKLEVLFNKIQGE....
G3PC75_GASAC/343-384                   MERKPEGGVVFRSVRAEEKEAKRFNGLKQKAMEILFAKIQDE....
A0A3Q7RZM0_VULVU/2849-2890             MERTPSGLCIFRNEREEEKEATKYAETQQKKLEVLFNKIQAE....
A0A2Y9RLS4_TRIMA/537-578               VEKTSSGLYIFRDERAEEKEAAKYAETQQKKLEALLTKIQVE....
A0A2K6QQ81_RHIRO/2833-2874             MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEE....
A0A1S2ZJK9_ERIEU/2766-2807             VEKTSSGLYIFRSEREEEKEAAKFAEAQQKKLEAIFTKIQAE....
A0A2I0MCT6_COLLI/2802-2843             MEKTSAGSYVFRNNRAEEREAAKHAEDQQKKLEALFAKIQAE....
A0A2Y9KYL6_ENHLU/2859-2900             MERTPSGLCIFRNEREEEKEATKYAEAQQKKLEVLFNKIQGE....
G3W9Q7_SARHA/2790-2831                 MEKTLSGLYIFRNERAEEKEALKHAECQQKKLEALLTKIQAE....
I3LFN0_PIG/2624-2665                   MEKTSSGLYIFRNEREEEKEATKYAEAQQKNLEALFTKIQAE....
A0A2K5RU94_CEBCA/2538-2579             MEKTSSGLYIFRKEREEEKEAAKHAEAQQKRLEALFTKIQEE....
H2NJK5_PONAB/2828-2869                 MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKFQEE....
Q66MH4_RAT/2761-2802                   VEKTVSGSYIFRNEREEEKEALRFAEAQQKKLEALFTKVHTE....
A0A2D0SX90_ICTPU/2134-2175             MEKKPGPVFVFRNERAEDREAARYSSTKQKTMEFLFSKIQAQ....
A0A3Q0DCY9_MESAU/2553-2594             VEKTASGLYVFRNEREEEKEAVRFAGAQQKRLEVLFTKIQAE....
W5L0S8_ASTMX/1983-2024                 MEKRTGGVFVFRNERAEDREARRHSSAKQKTMELLFTRIQAQ....
A0A401S853_CHIPU/2819-2860             MEKKSNGTYVFRNERAEEREAQIHYENEQRKLELLYAN----teae
W4Z4A8_STRPU/147-188                   MEKLPEGGSVFRNAKEEAKAAALHASRKQNKMEQLFTQIQKQ....
A0A060Y4H5_ONCMY/1843-1884             MEKKSDGGFVFRAGRAEEREARRHGNAKHRAMEILFAKIQAQ....
A0A452RG86_URSAM/2782-2823             MERTPSGLCIFRNEREEEKEATKYAEAQQKKLEVLFNKIQGE....
A0A3Q1IDS8_ANATE/1469-1510             MERKSDGGIVFRSVRAEEKEARRYNSLQQKAMETLFAKIQAE....
A0A3B3R6U5_9TELE/2445-2486             MEKKPDGAYVFRSGRAEEREVQRHSASKQKTMETLFAKIQAQ....
BRCA2_MOUSE/2752-2793                  VEKTVSGLYIFRSEREEEKEALRFAEAQQKKLEALFTKVHTE....
#=GR BRCA2_MOUSE/2752-2793       SS    EEE-TTS-EEEE-CCHCCHHHHHHHHHCCCHHHHHHHHHHTT....
F7BTV7_CALJA/2823-2864                 MEKTSSGLYIFRNEREEEKEAAKHAEAQQKRLEALFTKIQEE....
A0A384C7I9_URSMA/2853-2894             MERTPSGLCIFRNEREEEKEATKYAEAQQKKLEVLFNKIQGE....
A0A3Q0GXG7_ALLSI/2728-2769             MEKKTTGSYVFRNNRAEEREAAKHAENQQKHLEALFAKIQAE....
G1QK32_NOMLE/2832-2873                 MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEE....
A0A1S3JJD8_LINUN/3535-3576             MEKLPNGSNVFRCGRMEERESKKFEQTRQERMERLLARIQA-d...
A0A3B3B7M7_ORYME/2403-2444             MERKADGGVVFRTTRAEEREARRFSEVKHKAMEVLFAKVQTE....
F7ER68_MACMU/2835-2876                 MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEE....
A0A3B3VP71_9TELE/2537-2578             MERKSDGGVVFRSVRAEEKEARRFNSHKQKAVELLFAKVQAE....
A0A0L8GLI0_OCTBM/1742-1783             MEKVSGSRAVFRSSHNERKAEEQYKRIQQETLERVYNKVQQ-n...
A0A091INQ8_EGRGA/2785-2826             MEKTSAGSYVFRNSRAEEREAAKHAEDQQKKLEALFAKIQAE....
A0A402EBG8_9SAUR/2667-2708             MEKLSTGHYVFRNERAEEREAAKHKENQQKTMQALLAKIQA-k...
A0A2U3WDR6_ODORO/2848-2889             MERTLSGVCIFRNEQEEEKEATKYAEAQQKKLEVLFNKIQGE....
W5MNK3_LEPOC/357-398                   MEKKADGVFVFRGDRAEEREARRHNENKQKTMEALFAKIQSE....
A0A1L8HIX3_XENLA/2648-2689             MEKMASGLYVFRSDRAEEREAEKHSANQQKKLEMLFSKIQAE....
A0A1U7U304_TARSY/2844-2885             MEKTSSGLYLFRNQREEEKEAAKYAEAQQKRLEALFTKVQAE....
A7SNN6_NEMVE/309-350                   MEKLSDGTTVFRCARAEDRESNHYHMEQERAREDLLSRVQRE....
A0A3Q7WEX9_URSAR/2866-2907             MERTPSGLCIFRNEREEEKEATKYAEAQQKKLEVLFNKIQGE....
K1RH48_CRAGI/2166-2207                 MEKLPDGGSVFRTAQAEEKFSQLYQKQQQDAMESLYRKLE--kd..
A0A2I3RQQ1_PANTR/2799-2840             MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEE....
A0A1S3SX37_SALSA/2330-2371             MEKKSDGGFVFRAGRAEEREARRHGDSKHRAMEILFAKIQAQ....
J9K360_ACYPI/1050-1091                 LEKKTNSKSIFRNEKMETIEAEKYKAYQQKSLEIISNKIKTE....
G1LS71_AILME/2863-2904                 MERTPSGLCIFRNEREEEKEATKYAEAQQKKLEVLFNKIQGE....
A0A340XSP0_LIPVE/2839-2880             MEKTSSGLYIFRNEREEEKEARKYAEAQQKKLEALFTKIQAE....
A0A3Q0GSV1_ALLSI/2711-2752             MEKKTTGSYVFRNNRAEEREAAKHAENQQKHLEALFAKIQAE....
A0A452C3D5_BALAS/2745-2786             MEKTSSGLYIFRNEREEEKEATKYAEAQQKKLEALFTKIQAE....
A0A2I4BP92_9TELE/2506-2547             MERKADGGIVFRSSRAEEKEARLFNNHKQTAMETLLAKIQAE....
F7E9I9_XENTR/2600-2641                 MEKMANGLYVFRNDRAEEREAEKHSANQQKKLEMLFSKIQAE....
W5PNG4_SHEEP/2800-2841                 MEKTSTGLYIFRNEREEEKEATKYAEVQQKKLEALFTKIQAE....
A0A3P8XPR1_ESOLU/2319-2360             MEKKLDGGFVFRSQRAEETEQQRHEQAENRAREILCAKIQAQ....
A0A1S3SX34_SALSA/2318-2359             MEKKSDGGFVFRAGRAEEREARRHGDSKHRAMEILFAKIQAQ....
G5E764_LOXAF/2767-2808                 VEKTPSGLYIFRDERAEEKEAAKYAETQQKKLEALLAKIQAE....
A0A2U9B4U4_SCOMX/2241-2282             MERKPDGGVVFRSVRAEEKEARRYSSHQQKAMEILFAKIQTE....
A0A091IID7_CALAN/2792-2833             MEKTSAGSYVFRNSRAEEREAARHEEDQQKKLEALFAKIQAE....
M3ZXN9_XIPMA/2555-2596                 MERKSDGGVVFRSARAEEKEARRFNSHKQKAVELLFAKVQAE....
U3IJI9_ANAPP/2784-2825                 MEKTSAGSYVFRNSRAEEREAVRHAEDQQKKLEALFAKIQAE....
A0A3B3WDX8_9TELE/2184-2225             MERKSDGGVVFRSVRAEEKEARRFNSHKQKAVELLFAKVQAE....
A0A087QM77_APTFO/2817-2858             MEKTSGGSYVFRNSRAEEREAAKHAEDQQKKLEALFAKIQAE....
A0A3B4WQB3_SERLL/2238-2279             MERKPDGGVVFRSVRAEEKEARRYSSHKQKAMEILFAKIQTE....
A0A151MPQ2_ALLMI/428-469               MEKKPTGSYVFRNNRAEEREAAKHAENQQKHLEALFAKIQAE....
W5MNL3_LEPOC/350-391                   MEKKADGVFVFRGDRAEEREARRHNENKQKTMEALFAKIQSE....
H0ZNF4_TAEGU/2747-2788                 MEKTSAGSYVFRNSRAEEREAAKHAEDQQKKLEALFAKIQAE....
H3AGP4_LATCH/592-633                   MEKKSDGIFVFRNDRAEEREAQRQVENQQRKMESLFAKIQTE....
A0A3Q1LJN4_BOVIN/2564-2605             MEKTSTGLYIFRNEREEEKEATKYAEAQQKKLEALFTKIQAE....
A0A091WEP0_OPIHO/2816-2857             VEKTSAGSYVFRNSRAEEREAAKHAEDQQKKLEALFAKIQAE....
A0A1U8D5M6_ALLSI/2729-2770             MEKKTTGSYVFRNNRAEEREAAKHAENQQKHLEALFAKIQAE....
A0A091UQ74_NIPNI/2805-2846             MEKTSAGSYVFRHSRAEEREAAKHAKDQQKKLEALFAKIQAE....
G5B7X6_HETGA/2694-2735                 MEKTSSGLYIFRNEREEEKEAAKHAEAQQKKLEVLFTKIQGQ....
A0A099ZWS6_TINGU/2823-2864             MEKTSSGSYVFRNSRAEEREAAKHAEEQQKKLEALFAKIQEE....
H0YD86_HUMAN/1-38                      ----SSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEE....
A0A3Q4IA78_NEOBR/1895-1936             MERKPDGSVVFRSSRAEEKEARRYNSHKQKAMEILFAKIQSE....
K7JTG8_NASVI/1629-1668                 -EKTPDGQSIYRNARSEEKAAIAYERALEKQVDAMYAQ----aek.
G1PNI9_MYOLU/2780-2821                 MEKTSSGLYIFRNEREEEKEAAKYAEAQQRKLEALFTKIQAE....
L9JDB5_TUPCH/2707-2748                 MEKTSSGSYIFRNEREEEKEAAKYAEAQQKKLEDLLTKIQA-d...
M3XS78_MUSPF/2857-2898                 MERTPSGLCIFRNEREEEKEATKYAEAQQKKLEVLFNKIQGE....
A0A1S3SX55_SALSA/2328-2369             MEKKSDGGFVFRAGRAEEREARRHGDSKHRAMEILFAKIQAQ....
A0A3Q1AWU5_AMPOC/2461-2502             MERKTDGGAVFRSVRAEEKEARRYNNHKQKAMETLFTKIQSE....
A0A091DSV6_FUKDA/2771-2812             MEKTSSGLYIFRNEREEEKEAAKHTEAQQKKLEVLFTKIQAQ....
F6XH22_MONDO/2817-2858                 MEKTLSGSYIFRNERAEEKEALKYAECQQKKLEALLTKIQAE....
A0A2K5RU61_CEBCA/2538-2579             MEKTSSGLYIFRKEREEEKEAAKHAEAQQKRLEALFTKIQEE....
A0A2Y9EMN5_PHYMC/2827-2868             MEKTSSGLYIFRNEREEEKEATKYAEAQQKKLEALFTKIQAE....
A0A093KA59_STRCA/2822-2863             MEKTSTGSYVFRNSRAEEREAAKYAEDQQKKLEALFAKVQAE....
A0A1V4K9L4_PATFA/2841-2882             MEKTSAGSYVFRNNRAEEREAAKHAEDQQKKLEALFAKIQAE....
A0A2K6CN06_MACNE/2835-2876             MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEE....
A0A1S3SX28_SALSA/2334-2375             MEKKSDGGFVFRAGRAEEREARRHGDSKHRAMEILFAKIQAQ....
A0A3Q3FAJ5_KRYMA/2172-2213             MERKADGSVVFRSARAEEKEARRYNHHQQTAMETLFAKIQAE....
H0X313_OTOGA/2820-2861                 MEKTSSGLYIFRNEREEEKEAAKYAEAQQKRLEALFTKIQAE....
I3JDK0_ORENI/2327-2368                 MERKPDGSVVFRSSRAEEKEARRYNSHKQKAMEILFAKIQSQ....
A0A2K5VXA2_MACFA/2833-2874             MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEE....
A0A3M6TPC3_9CNID/1907-1948             MEKMPDGTNVFRNSRLEEREAKKFEADRHQRREKLFIKIQEE....
H3C2G7_TETNG/602-643                   MERKPEGGTVFRSGRAEEKEARRYNVHKEKAMEILFDKIQAE....
A0A452RG22_URSAM/2861-2902             MERTPSGLCIFRNEREEEKEATKYAEAQQKKLEVLFNKIQGE....
A0A2B4S5I5_STYPI/1882-1923             MEKMPDGTNVFRNSRHEEREVKKFETDRHQRREKLFLKIQEE....
A0A0D9RZ99_CHLSB/2834-2875             MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEE....
A0A226MS07_CALSU/2326-2367             MEKTSSGSYVFRNSRAEEREAAKHAEGQQKKLEALFAKIQAE....
M7BD34_CHEMY/2726-2767                 VEKVPTGSYVFRNGRAEEREAAKHAENRQKHLEALFSQIQVE....
F6RE00_XENTR/2624-2665                 MEKMANGLYVFRNDRAEEREAEKHSANQQKKLEMLFSKIQAE....
A0A2R8ZDX5_PANPA/2830-2871             MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEE....
A0A1V4K9E8_PATFA/2897-2938             MEKTSAGSYVFRNNRAEEREAAKHAEDQQKKLEALFAKIQAE....
A0A3Q3A225_KRYMA/2049-2090             MERKADGSVVFRSARAEEKEARRYNHHQQTAMETLFAKIQAE....
G3SQY0_LOXAF/2775-2816                 VEKTPSGLYIFRDERAEEKEAAKYAETQQKKLEALLAKIQAE....
R0K5Y4_ANAPL/2763-2804                 MEKTSAGSYVFRNSRAEEREAARHAEDQQKKLEALFAKIQAE....
A0A2K5I125_COLAP/2832-2873             MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEE....
A0A091GDB0_9AVES/2804-2845             VEKTAAGSYVFRNRRAEEREAAKHAEDQQKKLEALFAKIQAE....
F7B8W7_ORNAN/2878-2919                 MEKTHTGSYVFRNERAEEKEASKHAESQQKKLEALYAKIQD-d...
F6TTA8_HORSE/2845-2886                 VEKTSAGSYIFRNEREEEKEAIKYAEAQQKKLEALFTKIQVE....
A0A3P9P903_POERE/2539-2580             MERKSDGGVVFRSVRAEEKEARQFNSHKQKAVELLFAKVQAE....
H0V4T0_CAVPO/2554-2595                 VEKTSSGLYIFRNEREEEKEAAKHAEAQQKKLEALFSRIQAQ....
K7FXU8_PELSI/2481-2522                 VEKMPTGSYVFRNGRAEEREAAKHAENRQKHLEALFSQIQME....
A0A498MF28_LABRO/1788-1829             MEKKPNGVFIFRNDRAEDREARKHSNSKHKSMDLLISKIQTQ....
E1B8X8_BOVIN/2829-2870                 MEKTSTGLYIFRNEREEEKEATKYAEAQQKKLEALFTKIQAE....
H2SRJ3_TAKRU/2222-2263                 MERKPEGGTVFRSGRAEEKEARRYNIHKEKAMEILFDKIKAE....
BRCA2_FELCA/2775-2816                  MEKTPSGLCIFRNEREEEREATKYAEAQQKKLEVLFNKIQAE....
A0A287B8J8_PIG/2703-2744               MEKTSSGLYIFRNEREEEKEATKYAEAQQKNLEALFTKIQAE....
A0A218V6H1_9PASE/2661-2702             MEKTSAGSYVFRNSRAEEREAAKHAEDQQKKLEALFAKIQAE....
A0A3B3I5Q9_ORYLA/2664-2705             MERKADGGVVFRTTRAEEKEARRFDEMKHKAMEVLFAKVQAE....
A0A2K5RU98_CEBCA/2808-2849             MEKTSSGLYIFRKEREEEKEAAKHAEAQQKRLEALFTKIQEE....
A0A3Q2WAQ0_HAPBU/2804-2845             MERKPDGSVVFRSSRAEEKEARRYNSHKQKAMEILFAKIQSE....
W5PNG2_SHEEP/2829-2870                 MEKTSTGLYIFRNEREEEKEATKYAEVQQKKLEALFTKIQAE....
A0A2K5LR30_CERAT/2834-2875             MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEE....
M3WZI6_FELCA/2778-2819                 MEKTPSGLCIFRNEREEEREATKYAEAQQKKLEVLFNKIQAE....
H2Q7E2_PANTR/2831-2872                 MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEE....
A0A3B4BU74_PYGNA/2253-2293             MEKK-SGVFVFRNDRAEDREARRHSSAKQKTMELLFSKIQAQ....
A0A232EKY0_9HYME/1627-1666             -EKTPDGQSIYRNARSEEKAATAYERALEKQVDAMYAQ----aek.
A0A2T7NK66_POMCA/1590-1631             MEKQADGSCVFRNAEMEDRARRCYEQQKEGAMERLCAKLQVE....
A0A2I3LGA1_PAPAN/2835-2876             MEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEE....
A0A2K5D388_AOTNA/2817-2858             MEKTSSGLYIFRNEREEEREAAKHAEAQQKRLEALFTKIQEE....
R7TCX8_CAPTE/163-204                   LEKLPDGSTCMRNLREEEKMANMHAKERESKIDSLYAKMQTE....
U3K1B7_FICAL/2793-2834                 MEKTTAGSYVFRNSRAEEREAAKHAEDQQKKLEALFAKIQAE....
A0A210QDY6_MIZYE/3673-3714             MEKLSEGGCVFRTGQAEDRFQHQHQRHRQEEMEKLYAKLQTE....
A0A151MPT0_ALLMI/429-470               MEKKPTGSYVFRNNRAEEREAAKHAENQQKHLEALFAKIQAE....
A0A2Y9NLY0_DELLE/2837-2878             MEKTSSGLYIFRNEREEEKEATKYAEAQQKKLEALFTKIQAE....
G3UEA2_LOXAF/638-679                   VEKTPSGLYIFRDERAEEKEAAKYAETQQKKLEALLAKIQAE....
A0A096LY08_POEFO/2526-2567             MERKSDGGVVFRSVRAEEKEARRFNSHKQKAVELLFAKVQAE....
A0A3Q3E6E1_9LABR/484-525               MERKSEGGVVFRSVRAEEKEARRYNSNKQKAMEILFAKIQAE....
A0A3S0ZXR0_ELYCH/343-384               MEKLSDGACIFRTREEEEKANRKHEEKRQDQIEKLYSSLQAE....
A0A3L8SUZ7_CHLGU/2765-2806             MEKTSAGSYVFRNSRAEEREAAKHAEDQQKKLEALFAKIQAE....
A0A3P9BYT6_9CICH/2804-2845             MERKPDGSVVFRSSRAEEKEARRYNSHKQNAMEILFAKIQSE....
A0A093S0V4_9PASS/2811-2852             MEKTSAGSYVFRNSRAEEREAAKHAEDQQKKLEDLFAKIQAE....
A0A0P7TGJ2_SCLFO/2050-2091             MEKLPNGAFVFRNGRAEDREARRHSDTKQKHMEALFNKVQAQ....
A0A1S3SX29_SALSA/2334-2375             MEKKSDGGFVFRAGRAEEREARRHGDSKHRAMEILFAKIQAQ....
G1TCK4_RABIT/2813-2854                 MEKTSSGFYIFRNEREEEKEAAKHAEVQQKKLEALFTKIQAE....
A0A4D9EIK0_9SAUR/2968-3009             VEKIPTGSYVFRNGRAEEREAAKHAENRQKHLEALFSQIQVE....
A0A2D0SXT8_ICTPU/2140-2181             MEKKPGPVFVFRNERAEDREAARYSSTKQKTMEFLFSKIQAQ....
A0A287AWN0_PIG/2613-2654               MEKTSSGLYIFRNEREEEKEATKYAEAQQKNLEALFTKIQAE....
#=GC SS_cons                           EEE-TTSSEEEE-CCHCCHHHHHHHHHCCCHHHHHHHHHHTT....
#=GC seq_cons                          MEKpusGhalFRNpRtEE+EAsKauEsQQK+LEsLFsKIQuE....
//
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