GenomeNet

Database: Pfam
Entry: Tox-GHH2
LinkDB: Tox-GHH2
Original site: Tox-GHH2 
#=GF ID   Tox-GHH2
#=GF AC   PF15635.7
#=GF DE   GHH signature containing HNH/Endo VII superfamily nuclease toxin  2
#=GF AU   Zhang D;0000-0001-8535-7620
#=GF AU   de Souza RF;0000-0002-5284-4630
#=GF AU   Anantharaman V;0000-0001-8395-0009
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   [1]
#=GF GA   25.00 25.00;
#=GF TC   26.60 26.10;
#=GF NC   24.30 23.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   22731697
#=GF RT   Polymorphic toxin systems: comprehensive characterization of
#=GF RT   trafficking modes, processing, mechanisms of action, immunity
#=GF RT   and ecology using comparative genomics.
#=GF RA   Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL   Biol Direct. 2012;7:18.
#=GF DR   INTERPRO; IPR028917;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   A predicted toxin of the HNH/Endonuclease VII fold present in
#=GF CC   bacterial polymorphic toxin systems with a characteristic
#=GF CC   s[AGP]HH signature motif. In bacterial polymorphic toxin
#=GF CC   systems, the toxin is exported by the type 2 or type secretion
#=GF CC   system [1].
#=GF SQ   45
#=GS A0A2T5PDI2_9PSED/200-314  AC A0A2T5PDI2.1
#=GS A0A0S4NWM1_9BURK/227-342  AC A0A0S4NWM1.1
#=GS A0A2N7TFR7_9GAMM/242-337  AC A0A2N7TFR7.1
#=GS G4T2Y2_META2/232-336      AC G4T2Y2.1
#=GS A0A369TG54_9RHOB/254-392  AC A0A369TG54.1
#=GS A4XUS8_PSEMY/216-332      AC A4XUS8.1
#=GS A0A2T5P5Y8_9PSED/246-378  AC A0A2T5P5Y8.1
#=GS A0A0Q6X7V8_9BURK/241-346  AC A0A0Q6X7V8.1
#=GS Q4KCC7_PSEF5/221-326      AC Q4KCC7.1
#=GS A0A1R4HAP7_9GAMM/236-329  AC A0A1R4HAP7.1
#=GS F6AA97_PSEF1/216-332      AC F6AA97.1
#=GS A0A090AFP7_9GAMM/210-310  AC A0A090AFP7.1
#=GS A0A1E2V1J2_9GAMM/253-371  AC A0A1E2V1J2.1
#=GS A0A158FVS7_9BURK/201-309  AC A0A158FVS7.1
#=GS A0A1W6L8K3_9BURK/248-381  AC A0A1W6L8K3.1
#=GS A0A0Q6XBZ8_9BURK/283-390  AC A0A0Q6XBZ8.1
#=GS A0A090ALE4_9GAMM/207-311  AC A0A090ALE4.1
#=GS A0A0J5T5I7_9RHOB/275-398  AC A0A0J5T5I7.1
#=GS A0A2A3C9B6_9RHIZ/177-303  AC A0A2A3C9B6.1
#=GS A4BPI5_9GAMM/176-287      AC A4BPI5.1
#=GS A0A2V3VPA1_9PROT/201-327  AC A0A2V3VPA1.1
#=GS Q9I733_PSEAE/226-343      AC Q9I733.1
#=GS V5DTA7_9GAMM/200-311      AC V5DTA7.1
#=GS B4EVA8_PROMH/400-498      AC B4EVA8.1
#=GS X7FDX3_9RHOB/258-386      AC X7FDX3.1
#=GS A0A0Q6X808_9BURK/155-271  AC A0A0Q6X808.1
#=GS A0A1P8WJX3_9PLAN/208-315  AC A0A1P8WJX3.1
#=GS A0A0Q6M085_9BURK/242-343  AC A0A0Q6M085.1
#=GS A0A2T5HQ52_9PSED/227-344  AC A0A2T5HQ52.1
#=GS A0A0B4XBQ1_9RHIZ/179-285  AC A0A0B4XBQ1.1
#=GS A0A370QLX3_9ENTR/232-343  AC A0A370QLX3.1
#=GS A0A085WIT7_9DELT/405-503  AC A0A085WIT7.1
#=GS A0A196Q376_9RHOB/305-398  AC A0A196Q376.1
#=GS A0A0H2LT51_VARPD/239-342  AC A0A0H2LT51.1
#=GS A0A0U3M9Q9_9BURK/317-430  AC A0A0U3M9Q9.1
#=GS A0A323USJ7_9RHOO/277-378  AC A0A323USJ7.1
#=GS A0A1M6AG73_9VIBR/408-508  AC A0A1M6AG73.1
#=GS A0A0D6SM11_9PSED/179-312  AC A0A0D6SM11.1
#=GS A0A0S2DJS3_LYSEN/402-497  AC A0A0S2DJS3.1
#=GS A0A369CBP1_9GAMM/224-329  AC A0A369CBP1.1
#=GS A0A0G3BJQ2_9BURK/248-377  AC A0A0G3BJQ2.1
#=GS A0A1G9A7F3_9PSED/247-348  AC A0A1G9A7F3.1
#=GS A0A1I7AAH0_9RHIZ/185-303  AC A0A1I7AAH0.1
#=GS A0A1I6JM43_9BURK/261-359  AC A0A1I6JM43.1
#=GS A0A370R2U3_9ENTR/272-378  AC A0A370R2U3.1
A0A2T5PDI2_9PSED/200-314             ..........KTPHHPIPVGEL...SESR.......KKGE...A--RGQ...........SRY.PK...YSDGAAPCICVEGKDH.......DsrnpV....S......T.ELDEH................GRVGAKFA..QLRNDKL..--...P...K.GTKL.............GAEYDFSIA.LD...CGAQA.VSSa.tgCDE...ACVRKQLEVAH................................................
A0A0S4NWM1_9BURK/227-342             ..........QTGHHLLPSAMF...DQYApelsgdkKTYK...AKMKNDg........rrPCW.KD...YDHNAALTICLEGTTN.......R....Sa..nG......S.HGHAH................--------..-EETGKI..VA...P...F.RKSA.............DMPYTSARD.EV...ADMFS.TMF...gCDS...KCLSEQLDDS-l...............................................
A0A2N7TFR7_9GAMM/242-337             ..........QTGDHLIEGASF...V--G.......L---...------...........PEW.GA...YSYSAAPTVCAEGPSW.......H....T....G......S.HRDLS................LYRHAATT..NLSKGGK..WS...R...-.----.............KKATRVGAK.SL...RMAFP.RSG....CSQ...KCIEAQLNNYH................................................
G4T2Y2_META2/232-336                 ..........QTPDHLIDVKSF...VEAG.......QDR-...TTGKRK...........PGW.DK...YNDKDAPSMCVEGGAA.......T....C....S......T.HGVLS................--------..--TKRKA..FV...N...Q.MGGK.............GAETDLETL.AI...VGAVT.ASDtfkgCSV...ECLEAQLLDYH................................................
A0A369TG54_9RHOB/254-392             ..........QTGHHVVPASSF...FNKG.......RGENpkpGELPLVihtp..pekppAGY.KKpppYDPKKAPVVCAEGCSN.......T....T....G......S.HGMMHtemka......aimarGHSIENVP..LQVQGQS..KP...Q...K.KTSMt...........yGEQKKEAIK.AM...EKTFP.LSK....CDP...ACIEAQLDDYH................................................
A4XUS8_PSEMY/216-332                 ..........KTPHHIVPKSQF...KERG.......KGGK...ALLLDS...........NGD.NK...YDPDKAPCICEDGHSH.......S....T....G......T.HGDIHeet..........nllTVTHPKVS..PHVTGKT..ID...P...-.----.............NARWDVADA.EA...VGAKA.TKKggsqCDE...ECTKSQVRAGH................................................
A0A2T5P5Y8_9PSED/246-378             ..........KTPHHVIPAHCF...MPAG.......ERKT...GDGGRY...........PGA.EK...YDDTKAPCICLEGATK.......S....D....TgpgglkE.HGRVHaiidv......kedefMSSSP---..-------..VM...G...K.TGQRtkkgqpmvkkeagTWTFKQAND.EG...SKAVT.EVKq..dCST...ACMAAQSESAH................................................
A0A0Q6X7V8_9BURK/241-346             kdmnkmkckkQTGEHLIE----...----.......----...-----Ka........scKGV.GG...YNENDAPTAFTEGPSN.......H....L....G......E.HGIVS................LDRKEFMA..DWLKTNP..PS...A...-.-WTM.............GEAADLGAD.VF...HEQNT.EPR....CNR...ECLKKQIIAGH................................................
Q4KCC7_PSEF5/221-326                 ..........QTPDHVIPKSSF...S---.......---V...GAFSNNk........rqPGW.EE...YSKDTAPCMCVEGWGN.......T....H....G......S.HGVRH................--------..--SEHKA..LG...V...I.AGVKkgd......mrefGKEASMAAQ.ST...RGAFP.ESN....CSE...RCLTAQLADGH................................................
A0A1R4HAP7_9GAMM/236-329             ..........QTGNHVIPASYF...D---.......----...------...........-GI.TG...YNHNDAPTMCVEGTSW.......H....S....G......N.HGYLH................--TAQSIL..DDFYKDS..SG...Q...-.-LSI.............QQAAKNGGQ.AQ...KEIFK.EQS....CDE...KCIKAQVIDGH................................................
F6AA97_PSEF1/216-332                 ..........KTPHHIVPKSQF...KELG.......KAGK...ALLLDK...........AGE.NK...YDPDKAPCICEDGHSH.......S....T....G......T.HGDIHeet..........nllTVGHPKVA..PHVTGKS..IS...P...-.----.............NARWDVADA.EA...VGAKA.TKKggaqCNE...ECTQKQVRASH................................................
A0A090AFP7_9GAMM/210-310             ..........QVAHHVIPQSAF...I---.......KNE-...---ENI...........PGW.CG...YNENEAPCICTEGHSY.......Y....D....D......K.HGDLH................--TLYGVI..AKEEKDE..--...Q...G.MWTQ.............QRATQTGAK.SI...TKVYP.NSK....CNP...ACLEAQLNKYH................................................
A0A1E2V1J2_9GAMM/253-371             ..........QTGHHLVEAAAC...FDTG.......RGGS...GSDAFV...........-DC.GT...YDQGKAPSICAEGTDH.......G....T....G......T.HGLMHtfqs........dsaiGCDAGEVT..CTSGKKV..QV...D...H.KTNY.............KDARDSGVD.AV...AEVFP.EAN....CSK...ACLTAQMDAYH................................................
A0A158FVS7_9BURK/201-309             .........t-TGHHAIPKQEM...CEEG.......SAGK...RPL--K...........-GN.EG...YKHEDAPCVCAEGGSPgkrdgdgM....V....G......S.HGLFH................NAYKQGRT..LHLEQSQ..--...-...-.---P.............WDYPSAKTV.AA...QSVSK.ETQ....CPV...DCIEKQIAVYH................................................
A0A1W6L8K3_9BURK/248-381             ..........KTPHHIVPAHCF...LPSG.......ERKS...GSGDRY...........PGT.DN...YDDMKAPCICVSGGTK.......S....EkqadGq...lmQ.HGRIHaivdv......lednkMDKSPALT..PGGKQKM..--...-...-.---Kagvp....vekksAGSWSFEEA.ND...AGSEA.VSQv.tqCDK...GCLKAQSEAAH................................................
A0A0Q6XBZ8_9BURK/283-390             ..........QTGHHLIEASAF...LEPG.......TRGK...GDVPRE..........qFKN.SK...YDINKAPCICAEGQNN.......T....A....A......S.HGLMH................------TY..QGVRAEK..IA...V...KgEWTL.............KQATDTAGQ.AT...KMVFP.NSD....CSP...GCISAQLKAYH................................................
A0A090ALE4_9GAMM/207-311             ..........KTGHHILPNSLL...Q--G.......TRG-...NSATNV...........PGLsDA...YTVNDGACVCVSGDDH.......S....S....G......D.HGELH................DRTKDKLR..TILQ---..-S...G...E.TLTY.............KQAKTEVTK.AH...AETFP.Q-Q....CNP...KCIEAQIDAS-l...............................................
A0A0J5T5I7_9RHOB/275-398             ..........QTPHHVVPKSSF...VDTN.......DSGK...AL----...........AGC.AN...YNGNDAPCICAEGASS.......T....K....G......S.HGRMHaflllaihkatslkgtFKPDTKTL..ALDKGGS..VQ...G...R.EMSY.............KQQREAGVA.SV...MKVFP.RSK....CSA...ACLAAQLDGYH................................................
A0A2A3C9B6_9RHIZ/177-303             .......kes---EHMLGNALM...QNKR.......GSRA...QSIPGF...........NGS.NG...YSASTAPCLCMDGPSS.......D....N....S......TeHGKKTrd............qeA----FKE..SLAIKDA..NG...N...P.TGRYrqptak.eaidaeLKSVRENHN.QI...KNAKP.KKKq..dEIM...ECLEAVI----ydhl............................................
A4BPI5_9GAMM/176-287                 .........g-TGHHLIPGRCM...RTRT.......TSLS...GESLAN..........pAYP.EG...CSHDKAPCVCVDNENQ.......Y....S....G......T.HRDCH................AIFDPVEF..ECA----..ES...G...K.PFTY.............GKARDTAAK.SA...AGINN.GKE....PSEnqlDCLKLQLDNYY................................................
A0A2V3VPA1_9PROT/201-327             .........m-TPHHVVLKSQF...YESG.......FAGL...SSKAAQdaga..llkddKGK.NK...YSINKAPCICEEGTSQ.......T....E....G......D.HGEIH................TETNIATL..EHESVKP..YL...TesgK.SIKK.............DAEWKVGES.EA...VGAQA.VEDv.tgCDK...DCIEAQVRQGH................................................
Q9I733_PSEAE/226-343                 ..........QTAHHLIEASAL...HDKG.......RGGK...GSVPLK...........-GI.SN...YSENKAPCVCAEGVNQ.......N....V....G......T.HGLMHtfq.........saaaAKSRSGTL..QLSNGSS..IS...A...K.KTTY.............GTAKRQSMA.AM...GKVFP.QSK....CSK...ECLSAQLDNYH................................................
V5DTA7_9GAMM/200-311                 .........m-TGHHLLPSKEF...VAHE.......--SR...GSADP-...........--A.TN...YVSNKAPTICLEGHDH.......N....K...kK......E.HGKVG................CNYTVEKN..KWVKNPL..NK...N...K.KYSL.............KNGCGVAAQ.SAigkVKVPA.GSK...gCDK...ACLAKQLEEGH................................................
B4EVA8_PROMH/400-498                 ..........QTGHHLIYSHLL...RETC.......K---...------...........---.-N...YEESIAPTVCVEGTSW.......H....S....G......S.HGRIH................MAMDDEIT..YLVENNR..LN...N...N.TMSM.............QQAIDAAVN.AH...KKTFP.YAD....CSN...RCIRAQLESYY................................................
X7FDX3_9RHOB/258-386                 ..........QTGHHLIPEFSF...A-TG.......THGD...GD-PLK...........-GC.KG...YDPQEAPTICVEGCCH.......T....K....G......S.HGLMHgeyyigfmsaaddgkgG------K..THKPKKK..LS...I...A.GKTKktgds...ynlthAEARKIATE.SV...AKVFP.VSD....CNP...DCIEAQLKEYH................................................
A0A0Q6X808_9BURK/155-271             .........t-TGHHVIPLGEFclpRSQS.......GGRR...GQAPLN...........DDV.SG...YDGNLAPTICVEGSDH.......K....P....G......P.DGQLK................--EHGLVG..SAYIRER..LK...K...G.IKNK.............QTGVKYSDL.RD...CGTAS.VSKifgqCSE...GCTKAQLDNYH................................................
A0A1P8WJX3_9PLAN/208-315             ........eq--PHHLVEAHCF...YEVGs....rgKPGK...RVVKAP...........RGK.RA...YNDGDSPCVCAKGPRH.......E....-....K......E.HGQYH................--------..--AFQQK..LE...A...A.HHSK.............NGSWTYKDA.RN...TGVKA.HKAvngqCSE...ECTTAQLDAYH................................................
A0A0Q6M085_9BURK/242-343             ..........QTADHLVPKASF...FVKG.......YED-...G--VKL...........PDW.QN...YDDSKAPCMCAEGGSN.......T....A....G......S.HGLRH................--------..--SHHKA..NG...P...G.KGVYh..........pfEAEVTLAAA.GA...AEVFK.GSG....CSQ...SCIEDQLRQGH................................................
A0A2T5HQ52_9PSED/227-344             ..........QTAHHLVEASAL...HDVG.......RGGK...GSTPLK...........-GI.SN...YNENKAPCVCAEGVNQ.......N....V....G......T.HGLMHtfq.........sassSRARKGEL..TTSKGAK..FT...A...K.KTTY.............KTAKTQAMT.AM...AKVFP.QSK....CSK...ACTEAQLDHYH................................................
A0A0B4XBQ1_9RHIZ/179-285             .......qqs---DHLLQNACV...N---.......--QK...RRGPAA...........PGF.GG...YDLDDAPCICLNDGTK.......T....R....T......Q.HGIKS................ALQNDWAT..KLRGDGK..VK...V...SyKEAR.............DENLKFTAA.GH...EGIR-.NSP....EAL...KCLKAIIDEY-f...............................................
A0A370QLX3_9ENTR/232-343             ..........QTPHHLLADSMF...KPCG.......VKR-...--TQSS...........PFS.SK...YSIGAAPNICMEGKRQ.......H....M....G......S.HQEIH................HDIAKEFL..NYMTDNMdpMG...S...P.KYPT.............KIPLDKSIElSS...RFVAA.EYG....CEP...DCIQQQLKSYY................................................
A0A085WIT7_9DELT/405-503             ..........QTGHHVLPHSMT...EGNC.......----...------...........---.PG...YKEDEAPTLCVEGVNW.......S....H....G......S.HGMMH................RALKARMD..DYKNGWF..GS...K...T.EISY.............EKARDLGIK.SI...TDTFP.ESK....CSE...DCLKAQLDKYY................................................
A0A196Q376_9RHOB/305-398             .........q-TKHHLIPEAMM...A---.......----...------...........-NC.PN...YNHSAAPTVCVEGVNS.......S....Q....G......S.HGAIH................----SALN..GILTRRH..PP...G...Q.PMTM.............QDGVNAAAD.SL...SDSGV.GDH....CRE...DCIKEQLERYY................................................
A0A0H2LT51_VARPD/239-342             ..........QTPDHVIPKSSF...YEAS.......VSK-...---GKK..........lPGW.KK...YKMSAAPCMCAEGPSN.......T....E....G......S.HGLRH................-ASHK---..-FMGRKV..GA...G...T.TQSF.............AKEMNLCLK.SV...QKVFK.SSN....CSN...KCLKAQLNEGH................................................
A0A0U3M9Q9_9BURK/317-430             ..........QTGHHVLPDAMF...YNYAp....atHPKT...GQVSMKka......gqrDCW.KK...YKHGDAPTMCLEGTTNr.....aT....N....G......S.HGLAH................AATNEFIE..DLRSSQD..IS...Y...-.----.............ETASSEIAQ.RL...GKPF-.--G....CNP...ACIKAQLDAYY................................................
A0A323USJ7_9RHOO/277-378             ..........QTGHHVIPDEAA...KDAC.......S---...------...........---.-N...YSHGGAPTICVEGANN.......S....N....G......T.HGKIH................TALDRSVQ..DHKDGGA..FGigaS...E.TISY.............GKMRDLGIK.SV...QATFP.ESK....CDT...KCLRAQLDAYY................................................
A0A1M6AG73_9VIBR/408-508             ..........QTGHHLVPDAWA...KNGC.......D---...------...........--A.SK...YNENAAPVVCVEGVSH.......S....I....G......S.HGTIH................DALDDIVI..DFYEKNK..EE...A...-.TVSI.............NKAINMASD.AH...RNSFGlISD....CNE...QCIKAQLRSYY................................................
A0A0D6SM11_9PSED/179-312             ..........KTPHHVVPAHCF...LPSG.......ERKS...GSGDRY...........PGT.DS...YDDTKAPCICLEGATK.......S....D....S......A.DGKLKehgqvhaivdvaedkfMKSEKQFT..PTGKPKM..KK...G...E.EVIKk...........tAGSWSFEQA.ND...AGCDA.VSKvkqkCDK...ECMKAQSEAAH................................................
A0A0S2DJS3_LYSEN/402-497             ..........QTGHHVIPGAAF...K--G.......N---...ACYTGK...........---.--...--HTRAPTICVEGVNN.......S....H....G......S.HGAAH................-SALGRIL..TDA-GKS..-N...G...D.PISY.............EDMRNHAVR.AI...RESG-.AHH....CNE...DCLKSQLDAYY................................................
A0A369CBP1_9GAMM/224-329             .........m-TPHHVIPAHCF...MPPG.......ERSS...GGSARY...........AGC.DG...YSVADAPCICVEGAGK.......E....K....-......D.HGKIH................--------..DLVDDLE..DS...N...L.DGGQ.............AGSWDYDDA.AT...AGVMA.VGEi.thCDE...DCLRAQVDAYH................................................
A0A0G3BJQ2_9BURK/248-377             ..........QTPHHLVEAGAF...HDQG.......RGGK...TWKDLEeggfkyqgrsiAGT.EK...YDANKAPCICVEGESQ.......H....Q....A......S.HKLMHeaq.........ndltNDSPAGPL..ALCGSSF..LS...E...K.TVTL.............GRAQSNGAQ.AV...VTVFP.DSG....CDP...GCIEAQLKNYH................................................
A0A1G9A7F3_9PSED/247-348             ..........QTGDHLVDAASF...G--P.......RNG-...---AKI...........EGW.SK...YKTNKAPVMCAEGPNQ.......T....T....A......T.HGQMH................--TRRGVV..ALHEADA..KG...E...-.-WPR.............SKATQTGAK.AA...RKTFP.DSN....CSQ...ECLEAQLNKYH................................................
A0A1I7AAH0_9RHIZ/185-303             ........eq--SDHIVQTACF...T-EG.......RDG-...PPIPTA...........GPK.AK...YDINKAPCVCLKDASK.......R....E....T......Q.HGEKS................ATQRQSKR..DWVAKKK..ND...-...-.----.............---------.--...-----.---....---...-----------aswqptykdarednldamkdaldpqindgpngeehpavgclrtacddy
A0A1I6JM43_9BURK/261-359             ..........QTGHHLIPDAAV...KDAG.......C---...------...........---.PG...YDYEAAPTVCAEGTGN.......S....H...gG......S.HQRLH................DVLDRRMR..EHKERRG..TN...Q...-.-ISY.............ADYRTQAMM.AF...YETFP.ESG....CSR...KCLQAQLDAHY................................................
A0A370R2U3_9ENTR/272-378             ..........QTGHHVVPHAMA...K---.......----...-----T...........AEC.KK...YGYGSAPCICVEGTTH.......S....R....G......S.HKEMHea............fgSRMREAVVdkMLATGKD..LD...L...I.TLSM.............DEAIDVGAQ.SV...IDTFS.SNS...gCSK...SCIQEQLKSYY................................................
#=GC seq_cons                        ..........QTuHHllPsutF...t.tu.......ptt....s.................sh.ss...YstscAPslCsEGssp.......s....p....G......o.HGthH...................ptthh..thtptpt..hs...s...t.thsh.............ppshshusp.uh...tpshs.pup....Csp...cClcAQLcsYH................................................
//
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