GenomeNet

Database: Pfam
Entry: Tox-HNH-HHH
LinkDB: Tox-HNH-HHH
Original site: Tox-HNH-HHH 
#=GF ID   Tox-HNH-HHH
#=GF AC   PF15637.7
#=GF DE   HNH/Endo VII superfamily nuclease toxin with a HHH motif
#=GF AU   Zhang D;0000-0001-8535-7620
#=GF AU   de Souza RF;0000-0002-5284-4630
#=GF AU   Anantharaman V;0000-0001-8395-0009
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   [1]
#=GF GA   26.10 26.10;
#=GF TC   26.10 28.80;
#=GF NC   26.00 20.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   22731697
#=GF RT   Polymorphic toxin systems: comprehensive characterization of
#=GF RT   trafficking modes, processing, mechanisms of action, immunity
#=GF RT   and ecology using comparative genomics.
#=GF RA   Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL   Biol Direct. 2012;7:18.
#=GF DR   INTERPRO; IPR028915;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   A predicted toxin of the HNH/Endonuclease VII fold present in
#=GF CC   bacterial polymorphic toxin systems with characteristic
#=GF CC   conserved s[GD]xxR and HHH motifs. In bacterial polymorphic
#=GF CC   toxin systems, the toxin is exported by the type 2, type 5, type
#=GF CC   6, type 7 or Photorhabdus virulence cassette (PVC)-type
#=GF CC   secretion system [1].
#=GF SQ   25
#=GS D3IMT1_9BACT/162-263        AC D3IMT1.1
#=GS A0A0V8JGY4_9BACI/493-557    AC A0A0V8JGY4.1
#=GS A0A0V2FHW2_CAUVI/4324-4426  AC A0A0V2FHW2.1
#=GS A0A1S8TNU6_9CLOT/513-615    AC A0A1S8TNU6.1
#=GS A0A3M6QXU4_9BURK/1-103      AC A0A3M6QXU4.1
#=GS A0A368L1I9_9BURK/305-407    AC A0A368L1I9.1
#=GS C3KCX5_PSEFS/3937-4033      AC C3KCX5.1
#=GS A0A368KNI6_9PLAN/11-85      AC A0A368KNI6.1
#=GS A7GQ42_BACCN/1-99           AC A7GQ42.1
#=GS Q82QU7_STRAW/252-355        AC Q82QU7.1
#=GS A0A0S7BTQ1_9CHLR/32-134     AC A0A0S7BTQ1.1
#=GS A0A0V8JI47_9BACI/1-103      AC A0A0V8JI47.1
#=GS H3SNR9_9BACL/51-153         AC H3SNR9.1
#=GS A0A1G9EWG2_9ACTN/624-715    AC A0A1G9EWG2.1
#=GS A0A222FAL7_9RHOB/2689-2791  AC A0A222FAL7.1
#=GS C7BSW2_PHOAA/31-133         AC C7BSW2.1
#=GS A0A3S3UQS2_9SPHI/2612-2716  AC A0A3S3UQS2.1
#=GS L1P5K4_9FLAO/5-65           AC L1P5K4.1
#=GS A0A368KMR0_9PLAN/100-196    AC A0A368KMR0.1
#=GS A0A2R7SB70_9PSED/2094-2190  AC A0A2R7SB70.1
#=GS I8J343_9BACI/546-650        AC I8J343.1
#=GS A0A1T4PPQ7_9BACT/2614-2713  AC A0A1T4PPQ7.1
#=GS D7VR58_9SPHI/1-48           AC D7VR58.1
#=GS A0A2A8SHW7_9BACI/71-134     AC A0A2A8SHW7.1
#=GS C7BNN3_PHOAA/1-89           AC C7BNN3.1
D3IMT1_9BACT/162-263                   ......................PRYSIDTTTFESGKPTANGG.--..LRDNKQFWQKWEKLNPSSISKNNRWRIEH....GLSPTIDNVWIKEFPEH....GG.YKGEILIHHHVDQGKYAVPVPASTHVGSGGVwHC.........
A0A0V8JGY4_9BACI/493-557               ....................kn--LIVEMPFVGKGKSSTNSE.GW..LRDHKYYFKELYKQHPEYFSKANIENLEN....GWAIKNDAVFRR-----....--.-------------------------------.--yl.......
A0A0V2FHW2_CAUVI/4324-4426             ......................PGVEIDMR-LAPANSGLNAA.GF..PRNGPWFWREMAKSSPQYFDATNRALIRA....GRSPIVNKAWADEFPSH....AG.FSGDKLVHHHIDQGPIATPIPEKVHRAWYKAlH-p........
A0A1S8TNU6_9CLOT/513-615               ......................PKYIVEMPYVGKNKKNSNSQ.GW..KRDSKFFFKELQSKHPEIFGKKNTSLIKK....GSIPIVDEKFIEHFPQY....AD.NLDEVIRHHHIGGGGQAMPIPDTLHPGYGGI.HN.........
A0A3M6QXU4_9BURK/1-103                 ....................mk--YAIDMQSIGTG-SGVNAF.GF..RRDSVAFFRGLLRINPELFSSSNQKLINN....RLSPVVDAQWVQHNPTH....QS.YQGAKIVHHHWMQGPVAIPIPEPLHVQWNSTlH-p........
A0A368L1I9_9BURK/305-407               ......................PGATIDMR-KAPESSGTNAA.GF..PRNGPWFWRQMAETNPEYFDAANLAKIRA....GRSPVVNDTWIENFPQH....QG.FSRDKLVHHHIDQGPIATPLPETIHQKWYKAlH-p........
C3KCX5_PSEFS/3937-4033                 ......................PAPVVTSGTTRTGVVRTNAA.DWrvLRDN---WDDL--GYGQILSTENRAAIAK....GKTPKVDDAWVKVFPED....AG.LKGERIPMHHVQGSPLTVPLPDTRHLDA---.--hm.......
A0A368KNI6_9PLAN/11-85                 kkrvltpfrppnrylienydkl--------------------.--..-----------------------------....KVSPRIDDEWIKVFPEH....AP.FKGDVIIHHHVDFGRYAIPVPRKTHVGSSGIwH-t........
A7GQ42_BACCN/1-99                      ......................------MPYVGKGQKNTNAE.GW..LRDKDFYWKEMLEKYPEAFNRSNRQKIEL....GFAPINNPTFRKHFPQYd..lKE.LYNDTLIHHHIGGGGQAVAVPSKLHPGLGGI.HN.........
Q82QU7_STRAW/252-355                   ......................PAEGVDMPWVGRGKGISSSElGY..LRDSKYFWPRFQQSYGSAISLANAQLIAS....GQAPRVDATWIEHFPGH....AA.YVNDTLEHHHVGQGSRAVPLPSRLHDAYTVF.HP.........
A0A0S7BTQ1_9CHLR/32-134                .....................d-DLLVSMRYNGDYHSSSNSQ.GW..DRNSSYYFENLLHNHPEYFSKKNMIRINN....NQSPKVDSQFVKNFPQY....KG.YENELLVHHHIGKDGQAVAIPASIHKGSGEI.HR.........
A0A0V8JI47_9BACI/1-103                 ......................------MPFGGKGEKYTNAE.GW..RRDLKYFWSELLDRHPEAFSPNNRAIIEGrnpfTDSPVNDKVFREYFSQYd..fKG.VKGDKLIHHHIGGGGQAFPVPQKLHPGSGGI.HN.........
H3SNR9_9BACL/51-153                    ......................PRLMVEMNYKGKGASGTNSA.GW..ERNSKKFFKELLKRNPEFWSEKNTSEIRR....GRAPEVDEHFVKYFPQY....MD.YLEDPLRHHHIGEGGQAAALPVTLHPGYGGV.HN.........
A0A1G9EWG2_9ACTN/624-715               ..................lrnk---------AGKTRPISTSM.GF..LRSESRFWRKF----EELFSE-DFKLIGK....GR--RVTKELAAKYGWD....PK.YVGDKLVHHHVENGQLVAAIPEGLHHELSGTiH-a........
A0A222FAL7_9RHOB/2689-2791             ......................PSFSVDTSAFTSGSATANGG.--..IRNSRQFWTAWLSMPNNGLSLANQAAVAS....KRAPIVDDDWLKVFPEH....KD.FRGQQLVHHHMDYGKYAIPVPRGAHNNSP--.--gfaywh...
C7BSW2_PHOAA/31-133                    ......................PKYSIDTSTFTSGKMTANGG.--..IRNNKEFWQQWSNLQPDSLSKSNMYRIKE...lGLSPKIDNQWIKAFPEH....VN.YKGETLIHHHVDFGRYAIPVPSSTHVGSGGIwH-t........
A0A3S3UQS2_9SPHI/2612-2716             ......vpanyksvsgrivktt----------------YTIH.GY..PRNYLYFWDKIIENNPKALDASNIYRVQR...lGLAPKVTPALREHLRSNgfdvTGlVDGEPLIHHHINGQSNAVVIGEANHR-----.--lip......
L1P5K4_9FLAO/5-65                      ...........elvslsyspak-----------------YKQ.EW..DKARKSYWLEQLERNPNRFSPKNKERIEK....GLSPQIE----------....--.-------------------------------.--ieiehkatg
A0A368KMR0_9PLAN/100-196               ......................PAPSASSNTTRLGVVRNNPR.DW..-RNLRDVWDQT--GVGDILSTRNRQRIAD....GLVPEVDDNWIRWFPGD....EA.LRGESIPMHHIQGTPLTVPLPASRHLDA---.--hm.......
A0A2R7SB70_9PSED/2094-2190             ......................PAPVVTSGTTRTGVVRTNAA.DWraLRDN---WDDL--GYSQILSTENRAAIAK....GKTPKVDDAWVKVFPED....AG.LKGERIPMHHVQGSPLTVPLPDTRHLDA---.--hm.......
I8J343_9BACI/546-650                   ......................PRLTVEMPYVGKGQKNTNAE.GW..LRDKDFYWKEMLKKYPEAFSKSNRQKIEL....GFSPINNTKFRKHFPQYd..lKE.LYNDTLIHHHIGGGGQAVAVPSKLHPGLGGI.HN.........
A0A1T4PPQ7_9BACT/2614-2713             .............plinmtpap-------------ARGTNAA.GV..PRNANWFFKQQLAANPEMFSEANKIKIKI....NRNPVVDAQWIKHNPAA....TK.YLGERLIHHHIEGGELAAAIPEKLHRDAF--.--selhp....
D7VR58_9SPHI/1-48                      .....................m--------------------.--..-----------------------------....------NDKWIQYNKTA....KA.YKGEKLVHHHHSQGRFAYAIPNKVHLKWNRVlH-v........
A0A2A8SHW7_9BACI/71-134                ......................PRLIVEIPYVGKGQKNTNAE.DC..LSDKDLYWKEMLEKHPEAFNKSNKQKMEL....GFSPINNPTFRK-----....--.-------------------------------.--y........
C7BNN3_PHOAA/1-89                      ....................mt------------------AN.GG..IRNNKEFWQQWSNLQPDSLSKSNMYRIKE...lGLSPKIDNQWIKAFPEH....VN.YKGETLIHHHVDFGRYAIPVPSSTHVGSGGIwH-t........
#=GC seq_cons                          ..........................lph.hhsput.tsNut.Ga..hRspphaWcch.ptpP-hhSpsNpttIpp....GhuPhlDspal+hFPpa....ts.hpG-pLlHHHlstGthAhslPpphH.s.sth.H..........
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