#=GF ID Tsi6
#=GF AC PF18660.2
#=GF DE Tsi6
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF08152
#=GF GA 26.90 26.90;
#=GF TC 28.60 28.30;
#=GF NC 26.40 26.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 29237732
#=GF RT Diverse NADase effector families mediate interbacterial
#=GF RT antagonism via the type VI secretion system.
#=GF RA Tang JY, Bullen NP, Ahmad S, Whitney JC;
#=GF RL J Biol Chem. 2018;293:1504-1514.
#=GF DR INTERPRO; IPR040818;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Tsi6 inhibits the NADase activity of Tse6, an integral membrane
#=GF CC toxin from Pseudomonas aeruginosa. The Tsi6 immunity protein
#=GF CC adopts an all-alpha-helical fold that binds to a surface of Tse6
#=GF CC [1].
#=GF SQ 30
#=GS G7Z743_AZOL4/9-89 AC G7Z743.1
#=GS A0A090VWM0_ESCVU/7-89 AC A0A090VWM0.1
#=GS A0A2N0ZX98_9GAMM/2-84 AC A0A2N0ZX98.1
#=GS Q88I97_PSEPK/5-87 AC Q88I97.1
#=GS A0A1H4FNW7_ALKAM/2-84 AC A0A1H4FNW7.1
#=GS A0A1N7SFE0_9BURK/5-83 AC A0A1N7SFE0.1
#=GS A0A0D6SLL5_9PSED/2-84 AC A0A0D6SLL5.1
#=GS X1XQC4_ACYPI/122-211 AC X1XQC4.1
#=GS S6V7Z9_PSESF/5-87 AC S6V7Z9.1
#=GS A0A1I3K1B5_9PSED/1-59 AC A0A1I3K1B5.1
#=GS A0A014MH20_9GAMM/9-91 AC A0A014MH20.1
#=GS A9BU08_DELAS/2-84 AC A9BU08.1
#=GS A0A1L6LD84_9DELT/11-93 AC A0A1L6LD84.1
#=GS A0A1T5LW87_9GAMM/2-85 AC A0A1T5LW87.1
#=GS M5DP83_9GAMM/4-88 AC M5DP83.1
#=GS A0A248JLL4_9PROT/13-93 AC A0A248JLL4.1
#=GS D3IMR9_9BACT/12-91 AC D3IMR9.1
#=GS A0A433SD84_9BURK/3-84 AC A0A433SD84.1
#=GS Q9I740_PSEAE/2-84 AC Q9I740.1
#=GS Q9I740_PSEAE/2-84 DR PDB; 4ZUY B; 2-84;
#=GS Q9I740_PSEAE/2-84 DR PDB; 4ZUY A; 2-84;
#=GS Q9I740_PSEAE/2-84 DR PDB; 5JTK A; 2-84;
#=GS Q9I740_PSEAE/2-84 DR PDB; 4ZV0 B; 2-84;
#=GS F8F4A3_TRECH/9-90 AC F8F4A3.1
#=GS A0A090UZA0_ESCVU/5-95 AC A0A090UZA0.1
#=GS F9D911_9BACT/15-93 AC F9D911.1
#=GS A0A1I1UAD5_9DELT/11-93 AC A0A1I1UAD5.1
#=GS A0A248JNA0_9PROT/59-139 AC A0A248JNA0.1
#=GS W0P9E0_9BURK/8-100 AC W0P9E0.1
#=GS A0A384KD88_YERPE/10-100 AC A0A384KD88.1
#=GS D4E4Q0_SEROD/4-86 AC D4E4Q0.1
#=GS A5G1B6_ACICJ/8-86 AC A5G1B6.1
#=GS Q2SFS3_HAHCH/4-83 AC Q2SFS3.1
#=GS A0A0J1GL55_9GAMM/6-87 AC A0A0J1GL55.1
G7Z743_AZOL4/9-89 .........elrrriarasa-----------GIAALA......GRE..PDNS.........WLTSIQRQLDYVDGAAR.DGA.KRLDRAA...DLNFGLLASHYVD..DIDPALAAELHAI------saat.........
A0A090VWM0_ESCVU/7-89 ....................TALDYINDAIHAVSKRI......SSN..SEFP.........LYTLAKEQLEYIKSILI.GTE.SDKSKLH...TLNLGALASKEFE..TTDEELAGHLSNANYIASQ.............
A0A2N0ZX98_9GAMM/2-84 ....................TSIETVQHGISLTTKRL......SDI..PDYD.........IYQSILKQLNYLLSVVD.GSE.ADSSMLD...KINVGHFAVREFE..ESDPEFSSILKKCQNIA--fk...........
Q88I97_PSEPK/5-87 ....................TPLGYVQKAIDITAQRN......KAC..PAYP.........IYGMLLNQLDYVKAVFE.GRE.QDKSKLH...QLSIGAIASKDFE..ENDPELARALKDAYYVAIQ.............
A0A1H4FNW7_ALKAM/2-84 ....................TPIEIVRKGISLTEKRL......KDI..PDFD.........IYQSIIKQLQYLLSIID.GSE.LDRSKLD...KIIVGHFAVREFE..ESDPELAEILKNCQSIA--fk...........
A0A1N7SFE0_9BURK/5-83 ................elly----KIDEALSVVEPM-......-LA..PTWP.........NVQSIHRQLMWCRAQIS.GET.SE-SKQG...PLTMGLIATREFEmwGDNPELAALINQI------qra..........
A0A0D6SLL5_9PSED/2-84 ...................s-VLEPLDHALVLVRERK......QRL..PGFA.........PYAQAEAELVYLRRAVQ.DPT.LDRTPLH...QGSLGALAVKEFE..ETDPELARALKDAHWIAAQ.............
X1XQC4_ACYPI/122-211 ....................STLDYVEKTLSLSQKRYae..vrKSN..PQSPl......lqMYDSTVQQLLFLRDLIE.GKE.KDKAKLW...KMTFGMYAAKEFD..NSDELFFERLSDAWFIVDQ.............
S6V7Z9_PSESF/5-87 ....................SALEYINHALLLAEERY......ARN..PQFS.........VYISLINQLLYVKSVFE.GVE.KDKSRLH...DLSLGALGAKEFE..DTDYELVRAIMDVSYIASQ.............
A0A1I3K1B5_9PSED/1-59 ....................-----------------......---..----.........MYSSLLNQLQYVKHCIE.DAG.IDRSRLH...DISVGHIAIREFE..ESDPEFAATLNRAYFIC--yy...........
A0A014MH20_9GAMM/9-91 ...................a-TLNYVTDAISIVELRL......KKN..PDFN.........LYVMALNQLRYVQAVLT.GAE.KDKSKLH...TMNLGVLASKEFD..TSDPDLAKNLSNVNYIASQ.............
A9BU08_DELAS/2-84 ....................TPLEYIDRALALVAQRA......LAL..PGHV.........FFQHLAQQLQYVRAVLL.DRG.LDRSRLH...QITIGSVAVKEFD..ETDPELARALKDAHYVAVQ.............
A0A1L6LD84_9DELT/11-93 ...............ldrrl------ESARKGVRDAI......ARH..PEID.........VLPEIGAQLDALHDETR.DGA.RPSHALR..dRLDFGQLASRHLH..AAEPALARDLYEIAS----wvay.........
A0A1T5LW87_9GAMM/2-85 ...................k-SIDAVQRALALARTRA......GKT..PGFP.........LYASCVAQLEYLLSNLD.GSVpVDRPKLR...TFTIGHYAVREFE..ESDEELARALKDAYLIASK.............
M5DP83_9GAMM/4-88 ...................k-IVDMIDEVLPEIQLKE......KTS..EDSN.........IYASIARQLEFLKNCYE.NGL.DYRVKLNg.kKLNFGIIASRNFA..GPEEELEEKISRINSYIIH.............
A0A248JLL4_9PROT/13-93 ..................vp---DLIRDALARCRRLR......EQW..PDIA.........TFASVHRQLDYLLKVAT.DPV.ADRSRLT...DIVIGVQAAREVE..TIDPDLADLLHTIN-----awan.........
D3IMR9_9BACT/12-91 ..................dq----LCDETMAYFKKIM......NDY..PQIT.........MYKSIYVQIWMIKKDLSeNVR.LDRVKDF..qKYSLGAIAAKNFD..EGD----------------vygdaigtidama
A0A433SD84_9BURK/3-84 erielllraqnqcgklmvmy-----------------......---..PENI.........TLQSIDSQIQYLIDLEN.GVT.NDRSKLS...QIIIGVQTAREIE..GLDENAADIFYKV------aseak........
Q9I740_PSEAE/2-84 ....................TPIEYIDRALALVVDRL......ARY..PGYE.........VLLSAEKQLQYIRSVLL.DRS.LDRSALH...RLTLGSIAVKEFD..ETDPELSRALKDAYYVGI-r............
#=GR Q9I740_PSEAE/2-84 SS ....................-HHHHHHHHHHHHHHHH......HHS..TT-H.........HHHHHHHHHHHHHHHHH.-TT.S-SCGGG...G--HHHHHHHHHT..TT-HHHHHHHHHHHHHHH-C............
F8F4A3_TRECH/9-90 .................sgl-----LDSASKMVNDRL......AHA..PGWQ.........VLQVIQTQLQAMQDDVN.HER.VPTAEAK..kRINIGVLAVREFE..ANDPEFADILIKAAYLYKK.............
A0A090UZA0_ESCVU/5-95 ....................TALDYVDRALRLAKKRH......HHI..K-YNviggdtlepMYNSIVQQLIFLHNIIT.GQE.TDKAKLW...KLTFGMYATKEFE..VTDPIFEDRLGDAFYIASQ.............
F9D911_9BACT/15-93 ...................k---EIVDLAIEETKNLM......EMS..PKVA.........IYASIYNQLVDIKQNII.GEN.KVFSRFElykRYSLGAVAVKNFD..ENADEYAQKLIDS------y............
A0A1I1UAD5_9DELT/11-93 ................dafa-------QVLAEARART......QALdpSQWP.........LLRRIADQLELMARATA.RGR.VPHEEDR..aRVDVGLIAAREFE..QTDPEYADQLQELEYT---frr..........
A0A248JNA0_9PROT/59-139 ...................t-SIQVSERALALAEARL......AAA..PEFS.........TYASLVAQLRYVLMALK.GGE.--RARLK...EIIVGHYAVREFA..ESDPELAEALMAAQAIAT-r............
W0P9E0_9BURK/8-100 ....................TAIEYVDRALIMANRRYeanrskQEL..ESISsl.....evMYDSIVQQLTFVRRILT.GEE.KDKARLW...ELTFGTYSAKEFD..ASDPVFFDRLGDAFFIASQ.............
A0A384KD88_YERPE/10-100 ....................TALDYVDRALRLAQKRHhh..ikYNV..IGGEtl.....epMYNSIVQQLIYLHNVIT.GEE.KDKTKLW...KLTFGMYATKEFE..ATDPIFEDRLGDAFYIASQ.............
D4E4Q0_SEROD/4-86 ....................TAIDYVNAALAVVKERQ......NTL..PSFP.........LYQSALNQIQYIKDILE.GNN.NDKSKLH...TITLGAYASKEFA..TTDPELAQHLSNVNYIASQ.............
A5G1B6_ACICJ/8-86 ..................pf-----LNEALRKVETLL......AAR..PGLP.........PLVSIRNQLIYLKQVCA.GT-.VGSERLP...ETILGIHAVRDIE..SWDIKLAYQIHRIDTV---vdr..........
Q2SFS3_HAHCH/4-83 ................ketl------CEAIAINEERL......KLT..PDFE.........IYHSIARQLNYLLAIVD.GKE.KDESKLD...KIILGHFAVREFE..ESDPELSQILKKCQNI---af...........
A0A0J1GL55_9GAMM/6-87 ...................l-KLAVCERALLLLQAQP......NAF..I-VP.........IYTSVEAQLHWLIDYFS.GKE.TDMKRLH...TLTFGHYAVRELS..PRYGELYAGLNAAFYVAEK.............
#=GC SS_cons ....................-HHHHHHHHHHHHHHHH......HHS..TT-H.........HHHHHHHHHHHHHHHHH.-TT.S-SCGGG...G--HHHHHHHHHT..TT-HHHHHHHHHHHHHHH-C............
#=GC seq_cons ......................lphlpcAlthsppRh......tph..Pshs.........hYsSlhpQLpYl+sslp.Gsp.tD+u+Lc...clslGthAs+EF-..poDPELActLpcs.hls...............
//
