GenomeNet

Database: Pfam
Entry: UBZ_FAAP20
LinkDB: UBZ_FAAP20
Original site: UBZ_FAAP20 
#=GF ID   UBZ_FAAP20
#=GF AC   PF15750.6
#=GF DE   Ubiquitin-binding zinc-finger
#=GF AU   Eberhardt R;0000-0001-6152-1369
#=GF SE   Jackhmmer:Q6NZ36
#=GF GA   25.00 25.00;
#=GF TC   25.10 38.60;
#=GF NC   24.80 24.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   22343915
#=GF RT   FAAP20: a novel ubiquitin-binding FA nuclear core-complex
#=GF RT   protein required for functional integrity of the FA-BRCA DNA
#=GF RT   repair pathway.
#=GF RA   Ali AM, Pradhan A, Singh TR, Du C, Li J, Wahengbam K, Grassman
#=GF RA   E, Auerbach AD, Pang Q, Meetei AR;
#=GF RL   Blood. 2012;119:3285-3294.
#=GF RN   [2]
#=GF RM   22266823
#=GF RT   Regulation of Rev1 by the Fanconi anemia core complex.
#=GF RA   Kim H, Yang K, Dejsuphong D, D'Andrea AD;
#=GF RL   Nat Struct Mol Biol. 2012;19:164-170.
#=GF RN   [3]
#=GF RM   22396592
#=GF RT   Fanconi anemia (FA) binding protein FAAP20 stabilizes FA
#=GF RT   complementation group A  (FANCA) and participates in interstrand
#=GF RT   cross-link repair.
#=GF RA   Leung JW, Wang Y, Fong KW, Huen MS, Li L, Chen J;
#=GF RL   Proc Natl Acad Sci U S A. 2012;109:4491-4496.
#=GF RN   [4]
#=GF RM   22705371
#=GF RT   A ubiquitin-binding protein, FAAP20, links RNF8-mediated
#=GF RT   ubiquitination to the Fanconi anemia DNA repair network.
#=GF RA   Yan Z, Guo R, Paramasivam M, Shen W, Ling C, Fox D 3rd, Wang Y,
#=GF RA   Oostra AB, Kuehl J, Lee DY, Takata M, Hoatlin ME, Schindler D,
#=GF RA   Joenje H, de Winter JP, Li L, Seidman MM, Wang W;
#=GF RL   Mol Cell. 2012;47:61-75.
#=GF DR   INTERPRO; IPR031490;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This domain is the ubiquitin-binding zinc-finger of the Fanconi
#=GF CC   anaemia-associated protein of 20 kDa [1-4].
#=GF SQ   86
#=GS F6QQ55_MOUSE/124-158      AC F6QQ55.1
#=GS A0A151N3T5_ALLMI/111-138  AC A0A151N3T5.1
#=GS A0A2K6QH89_RHIRO/142-176  AC A0A2K6QH89.1
#=GS G3TKV8_LOXAF/151-185      AC G3TKV8.1
#=GS FAP20_HUMAN/144-178       AC Q6NZ36.2
#=GS FAP20_HUMAN/144-178       DR PDB; 3WWQ L; 144-178;
#=GS FAP20_HUMAN/144-178       DR PDB; 3WWQ I; 144-178;
#=GS FAP20_HUMAN/144-178       DR PDB; 3WWQ F; 144-178;
#=GS FAP20_HUMAN/144-178       DR PDB; 3WWQ C; 144-178;
#=GS FAP20_HUMAN/144-178       DR PDB; 2MUR A; 8-42;
#=GS FAP20_HUMAN/144-178       DR PDB; 2MUQ A; 8-42;
#=GS A0A3Q2H8Q7_HORSE/226-253  AC A0A3Q2H8Q7.1
#=GS A0A1S3A5A4_ERIEU/150-184  AC A0A1S3A5A4.1
#=GS A0A2Y9K9U7_ENHLU/188-219  AC A0A2Y9K9U7.1
#=GS G1QH38_NOMLE/144-178      AC G1QH38.3
#=GS G3PHY0_GASAC/111-145      AC G3PHY0.1
#=GS A0A4D9F2N1_9SAUR/402-436  AC A0A4D9F2N1.1
#=GS A0A337S339_FELCA/147-181  AC A0A337S339.1
#=GS A0A1V4KNP9_PATFA/251-285  AC A0A1V4KNP9.1
#=GS A0A2Y9FZG6_TRIMA/184-218  AC A0A2Y9FZG6.1
#=GS A0A3B3BYI5_ORYME/101-135  AC A0A3B3BYI5.1
#=GS A0A493TN83_ANAPP/281-315  AC A0A493TN83.1
#=GS A0A452FG58_CAPHI/156-190  AC A0A452FG58.1
#=GS A0A383YU36_BALAS/44-78    AC A0A383YU36.1
#=GS A0A3Q2IB29_HORSE/177-211  AC A0A3Q2IB29.1
#=GS C3ZVQ8_BRAFL/547-581      AC C3ZVQ8.1
#=GS H2N9F2_PONAB/247-281      AC H2N9F2.1
#=GS G5ATI2_HETGA/221-255      AC G5ATI2.1
#=GS A0A452STU4_URSAM/146-180  AC A0A452STU4.1
#=GS A0A2U3XM09_LEPWE/123-157  AC A0A2U3XM09.1
#=GS A0A1S3IBR2_LINUN/287-321  AC A0A1S3IBR2.1
#=GS A0A2K5D5S1_AOTNA/117-131  AC A0A2K5D5S1.1
#=GS A0A2U9BZK9_SCOMX/249-283  AC A0A2U9BZK9.1
#=GS A0A2U3ZNV5_ODORO/155-189  AC A0A2U3ZNV5.1
#=GS A0A1S3HZR9_LINUN/324-358  AC A0A1S3HZR9.1
#=GS A0A060W5A5_ONCMY/365-399  AC A0A060W5A5.1
#=GS A0A1U7R4J7_MESAU/151-185  AC A0A1U7R4J7.1
#=GS M7AN64_CHEMY/281-315      AC M7AN64.1
#=GS A0A2U9C071_SCOMX/249-283  AC A0A2U9C071.1
#=GS A0A2K5YEI5_MANLE/122-156  AC A0A2K5YEI5.1
#=GS G3I1X2_CRIGR/230-264      AC G3I1X2.1
#=GS A0A2D0QXQ2_ICTPU/238-272  AC A0A2D0QXQ2.1
#=GS A0A3Q7WSW5_URSAR/289-313  AC A0A3Q7WSW5.1
#=GS A0A2U4CN70_TURTR/149-183  AC A0A2U4CN70.1
#=GS G3VZL7_SARHA/116-150      AC G3VZL7.1
#=GS A0A1U7RNS6_ALLSI/234-268  AC A0A1U7RNS6.1
#=GS A0A3Q3AEL4_CHICK/273-307  AC A0A3Q3AEL4.1
#=GS L5L954_PTEAL/171-205      AC L5L954.1
#=GS H0XP13_OTOGA/148-182      AC H0XP13.1
#=GS A0A340WMZ8_LIPVE/154-188  AC A0A340WMZ8.1
#=GS G1M497_AILME/26-59        AC G1M497.1
#=GS K6ZMW6_PANTR/144-178      AC K6ZMW6.1
#=GS A0A1A6HRI9_NEOLE/251-285  AC A0A1A6HRI9.1
#=GS W5NQ76_SHEEP/261-295      AC W5NQ76.1
#=GS FAP20_BOVIN/156-190       AC A5PKK9.2
#=GS A0A2K5W9N9_MACFA/143-177  AC A0A2K5W9N9.1
#=GS V4BM53_LOTGI/241-274      AC V4BM53.1
#=GS A0A096MRM1_PAPAN/122-156  AC A0A096MRM1.2
#=GS A0A1L8FG45_XENLA/261-295  AC A0A1L8FG45.1
#=GS K1PXK9_CRAGI/261-295      AC K1PXK9.1
#=GS A0A452STP7_URSAM/142-176  AC A0A452STP7.1
#=GS A0A2K6T0E4_SAIBB/128-162  AC A0A2K6T0E4.1
#=GS A0A2I4C704_9TELE/308-342  AC A0A2I4C704.1
#=GS A0A2Y9F0N8_PHYMC/149-183  AC A0A2Y9F0N8.1
#=GS R7VB13_CAPTE/129-163      AC R7VB13.1
#=GS A0A3Q1FJE5_9TELE/169-203  AC A0A3Q1FJE5.1
#=GS A0A1V4KNN4_PATFA/251-285  AC A0A1V4KNN4.1
#=GS FAP20_MOUSE/150-184       AC Q3UN58.2
#=GS A0A1S3LLY5_SALSA/336-370  AC A0A1S3LLY5.1
#=GS A0A401RZJ5_CHIPU/348-382  AC A0A401RZJ5.1
#=GS A0A096LQT8_POEFO/111-145  AC A0A096LQT8.1
#=GS U3BJM7_CALJA/144-178      AC U3BJM7.1
#=GS A0A0D9S8W0_CHLSB/143-177  AC A0A0D9S8W0.1
#=GS FAP20_RAT/148-182         AC D4AAA5.1
#=GS G3RB78_GORGO/232-266      AC G3RB78.2
#=GS A0A2D0QZY5_ICTPU/192-226  AC A0A2D0QZY5.1
#=GS A0A402EY79_9SAUR/383-417  AC A0A402EY79.1
#=GS A0A286ZSU9_PIG/159-192    AC A0A286ZSU9.1
#=GS A0A452DIP1_BOVIN/156-190  AC A0A452DIP1.1
#=GS F6ZY17_HORSE/201-228      AC F6ZY17.2
#=GS A0A401NMS3_SCYTO/337-371  AC A0A401NMS3.1
#=GS A0A3Q7T001_VULVU/86-120   AC A0A3Q7T001.1
#=GS A0A2Y9QGM3_DELLE/149-183  AC A0A2Y9QGM3.1
#=GS A0A2I0M397_COLLI/230-264  AC A0A2I0M397.1
#=GS A0A2K5Q8P1_CEBCA/144-178  AC A0A2K5Q8P1.1
#=GS T1FI40_HELRO/207-240      AC T1FI40.1
#=GS A0A2K6F2F8_PROCO/141-175  AC A0A2K6F2F8.1
#=GS A0A2K5N9H9_CERAT/143-177  AC A0A2K5N9H9.1
#=GS A0A2Y9QA54_DELLE/149-183  AC A0A2Y9QA54.1
#=GS A0A210PL42_MIZYE/454-488  AC A0A210PL42.1
#=GS A0A3L8S3H4_CHLGU/274-308  AC A0A3L8S3H4.1
#=GS L8YCL4_TUPCH/122-156      AC L8YCL4.1
F6QQ55_MOUSE/124-158                 ....LLSC...PLCQKAFDPKLTQLDVDSHLAQCLAECTEDV..
A0A151N3T5_ALLMI/111-138             ...h----...----HQFSGMLSQLDIDGHLAKCLSESADDV..
A0A2K6QH89_RHIRO/142-176             ....LRSC...PMCQKEFGLRLTQLDVDSHLAQCLAESTEDV..
G3TKV8_LOXAF/151-185                 ....LVCC...PMCQAEFSPRLSQLDIDAHLAQCLAESTDDM..
FAP20_HUMAN/144-178                  ....LRSC...PMCQKEFAPRLTQLDVDSHLAQCLAESTEDV..
#=GR FAP20_HUMAN/144-178       SS    ....-SBE...TTTTEB--TT--HHHHHHHHHHHHHHSSS--..
A0A3Q2H8Q7_HORSE/226-253             ahtw----...-------DCRLAQLDVDSHLAQCLAESTDDV..
A0A1S3A5A4_ERIEU/150-184             ....LRSC...PMCQVDFRPTLTQLDIDSHLAQCLAESTEDI..
A0A2Y9K9U7_ENHLU/188-219             ....LRSC...PMCQANFAP---GLDVDRHLAQCLAESAEDV..
G1QH38_NOMLE/144-178                 ....LRSC...PMCQKEFAPRLTQLDVDSHLAQCLAESTEDV..
G3PHY0_GASAC/111-145                 ....LQSC...PMCLVVFPDGFTQMDCDGHLAQCLSEVNVDV..
A0A4D9F2N1_9SAUR/402-436             ....LDSC...PMCLIQFTGTLSQLDIDSHLAKCLSESADDV..
A0A337S339_FELCA/147-181             ....LRTC...PMCQTDFAPGLAQLDIDNHLAQCLEGSAEDV..
A0A1V4KNP9_PATFA/251-285             ....LSSC...PMCLMRFSGTLSQLDIDGHLARCLSESADDV..
A0A2Y9FZG6_TRIMA/184-218             ....LVCC...PMCQAEFSTKLSQLDIDAHLAQCLAESTADV..
A0A3B3BYI5_ORYME/101-135             ....LQSC...PMCLQEFPSGFSQMDCDSHLAQCLSDMNVDV..
A0A493TN83_ANAPP/281-315             ....LSSC...PMCQIQFSGMMSQLDIDSHLARCLSESADDI..
A0A452FG58_CAPHI/156-190             ....LQSC...PMCQVDFVPGLAQLDIDSHLAQCLADSTDDI..
A0A383YU36_BALAS/44-78               ....LQSC...PMCQADFAPRLTQLDVDSHLARCLAESADD-a.
A0A3Q2IB29_HORSE/177-211             ....LRSC...PMCQADFDPGLAQLDVDSHLAQCLAESTDDV..
C3ZVQ8_BRAFL/547-581                 ....LRSC...PMCQEEFPPGMSQLETDGHIAACLSASSEDI..
H2N9F2_PONAB/247-281                 ....LRSC...PMCQKEFAPRLSQLDVDSHLAQCLAESTED-a.
G5ATI2_HETGA/221-255                 ....LQSC...PMCQKEFTAELTQLDVDGHLAQCLAESTEDV..
A0A452STU4_URSAM/146-180             ....LRSC...PMCAADFAPSLAPLDIDSHLAQCLAGSTEDV..
A0A2U3XM09_LEPWE/123-157             ....LRSC...PMCQADFAPSLAPLDIDGHLAQCLAESTEDV..
A0A1S3IBR2_LINUN/287-321             ....LDAC...PLCQMEFETSWSQMDIDGHIAACLASSEDDV..
A0A2K5D5S1_AOTNA/117-131             ....----...----------------DSHLAECLAESTEDV..
A0A2U9BZK9_SCOMX/249-283             ....LQSC...PMCLLVFPVGFTQMDCDGHLAQCLSQRNVDV..
A0A2U3ZNV5_ODORO/155-189             ....LRSC...PMCQANFAPSLTPLDIDGHLAQCLAESTEDV..
A0A1S3HZR9_LINUN/324-358             ....LDAC...PLCQMKFETSWSQMDIDGHIAACLASSEDDV..
A0A060W5A5_ONCMY/365-399             ...m-QSC...PMCLVPFPAGFTQMDCDSHLAKCLSEMTLDM..
A0A1U7R4J7_MESAU/151-185             ....LLSC...PLCQKAFDPTLTQLDVDSHLAQCLAESTEDV..
M7AN64_CHEMY/281-315                 ....LDSC...PMCLIQFTGTLSQLDIDSHLAKCLSESADDV..
A0A2U9C071_SCOMX/249-283             ....LQSC...PMCLLVFPVGFTQMDCDGHLAQCLSQRNVDM..
A0A2K5YEI5_MANLE/122-156             ....LRHC...PMCQKEFGPRLTQLDVDSHLAQCLAESTEDV..
G3I1X2_CRIGR/230-264                 ....LLSC...PLCQKAFDPTLAQMDVDSHLAQCLAESTEDV..
A0A2D0QXQ2_ICTPU/238-272             ....LECC...PMCLTLFPAGFSQMECDAHLAQCLSEMNVDV..
A0A3Q7WSW5_URSAR/289-313             .nsl----...---------GLAPLDIDSHLAQCLAGSTEDV..
A0A2U4CN70_TURTR/149-183             ....LQSC...PMCQAVFAPRLTQLDIESHLAQCLAESTDDV..
G3VZL7_SARHA/116-150                 ....LNGC...PMCQQQFTGKLSQLDIDSHLAKCLSESIEDV..
A0A1U7RNS6_ALLSI/234-268             ....LDSC...PMCQIQFSGMLSQLDIDGHLAKCLSESADDV..
A0A3Q3AEL4_CHICK/273-307             ....LDSC...PMCLIRFSETLSQLDIDGHLARCLSESTDDI..
L5L954_PTEAL/171-205                 ....LRSC...PLCQADFAPGLAQLDIDSHLAQCLADSTEDV..
H0XP13_OTOGA/148-182                 ....LQSC...PMCQKDFAPELTQLDIDVHLAQCLAESTEDV..
A0A340WMZ8_LIPVE/154-188             ....LQSC...PMCQAVFAPRLTQLDIESHLAQCLAESTDD-a.
G1M497_AILME/26-59                   ....LRGCvpqQFCAPHLAP----LDIDSHLAQCLAGSAEEV..
K6ZMW6_PANTR/144-178                 ....LRSC...PMCQKEFAPRLTQLDVDSHLAQCLAESTEDV..
A0A1A6HRI9_NEOLE/251-285             ....LLSC...PLCQKAFEPTLAKPDVDSHLAQCLAESTEDV..
W5NQ76_SHEEP/261-295                 ....LQSC...PMCQVDFVPGLAQLDIDSHLAQCLADSTDDI..
FAP20_BOVIN/156-190                  ....LQSC...PMCQVDFAPGLAQLDIDGHLAQCLADSTDDI..
A0A2K5W9N9_MACFA/143-177             ....LRSC...PMCQKEFGPRLTQLDVDSHLAQCLAESTEDV..
V4BM53_LOTGI/241-274                 ..tl---C...PICLLTFPSSVYQIEIDSHIASCLSLADDDV..
A0A096MRM1_PAPAN/122-156             ....LRRC...PMCQKEFGPRLTQLDVDSHLAQCLAESTEDV..
A0A1L8FG45_XENLA/261-295             ....LESC...PMCLMQFSKRLSQLDIDSHLAQCLSETTVDM..
K1PXK9_CRAGI/261-295                 .vsq---C...PMCGKSFGPSFTMLDVDSHLANCLSATDDDV..
A0A452STP7_URSAM/142-176             ....LRSC...PMCAADFAPSLAPLDIDSHLAQCLAGSTEDV..
A0A2K6T0E4_SAIBB/128-162             ....LRSC...PMCQKEFAPRLTQLDVDSHLAQCLAESTEDV..
A0A2I4C704_9TELE/308-342             ....LQSC...PMCLQPFPAGSTQMDRDGHLAQCLSEMNVD-l.
A0A2Y9F0N8_PHYMC/149-183             ....LQSC...PMCQADFAPRLTQLDVESHLARCLAESTGD-a.
R7VB13_CAPTE/129-163                 ...v-ACC...PLCQVAFLPGQDQMSRDSHIAVCLSETDD--vv
A0A3Q1FJE5_9TELE/169-203             ....LQSC...PMCLQQFPAGFTQMDCDGHLAQCLSEMNVDM..
A0A1V4KNN4_PATFA/251-285             ....LSSC...PMCLMRFSGTLSQLDIDGHLARCLSESADDV..
FAP20_MOUSE/150-184                  ....LLSC...PLCQKAFDPKLTQLDVDSHLAQCLAECTEDV..
A0A1S3LLY5_SALSA/336-370             ...m-QSC...PMCLVPFPAGFTQMDCDSHLAKCLSEMTVDM..
A0A401RZJ5_CHIPU/348-382             ....LESC...PMCLMQFPAGFSVLEVDNHLAKCLSESTEDV..
A0A096LQT8_POEFO/111-145             ....LQSC...PMCLHVFPSGFTQMERDGHLAQCLSELSVDM..
U3BJM7_CALJA/144-178                 ....LHSC...PMCQKEFAPGLTQLDVDSHLAQCLAESTEDV..
A0A0D9S8W0_CHLSB/143-177             ....LHRC...PMCQKEFGPRLTQLDVDSHLAQCLAESTED-l.
FAP20_RAT/148-182                    ....LLNC...PLCQKAFDPKLTQLDVDSHLAQCLAESTEDV..
G3RB78_GORGO/232-266                 ....LRSC...PMCQKEFAPRLTQLDVDSHLAQCLAESTEDV..
A0A2D0QZY5_ICTPU/192-226             ....LECC...PMCLTLFPAGFSQMECDAHLAQCLSEMNVDV..
A0A402EY79_9SAUR/383-417             ....LDCC...PMCQFRFAGTLSQLDRDGHLAKCLSESTEDV..
A0A286ZSU9_PIG/159-192               ....LQSC...PMCQADFTRGLAPLDIDGHLARCLAENAGD-..
A0A452DIP1_BOVIN/156-190             ....LQSC...PMCQVDFAPGLAQLDIDGHLAQCLADSTDDI..
F6ZY17_HORSE/201-228                 ahtw----...-------DCRLAQLDVDSHLAQCLAESTDDV..
A0A401NMS3_SCYTO/337-371             ....LESC...PMCLVPFPAGFTVLEVDSHLAKCLSESTEDV..
A0A3Q7T001_VULVU/86-120              ....LRSC...PMCQVDFAPRLAQLDIDSHLAQCLAESTEDV..
A0A2Y9QGM3_DELLE/149-183             ....LQSC...PMCQAVFAPRLTQLDIESHLAQCLAESTDDV..
A0A2I0M397_COLLI/230-264             ....LDSC...PMCLIRFSGTLSQLDIDGHLARCLSESADDV..
A0A2K5Q8P1_CEBCA/144-178             ....LRSC...PMCQKEFAPRLTQLDVDSHLAQCLADSTEDV..
T1FI40_HELRO/207-240                 ..eq---C...PICLKEFELNFSQIEKDGHLARCLSGVTDDV..
A0A2K6F2F8_PROCO/141-175             ....LQSC...PMCQQEFASGLTQLDIDSHLAQCLAESTEDM..
A0A2K5N9H9_CERAT/143-177             ....LRRC...PMCQKEFGPRLTQLDVDSHLAQCLAESTEDV..
A0A2Y9QA54_DELLE/149-183             ....LQSC...PMCQAVFAPRLTQLDIESHLAQCLAESTDDV..
A0A210PL42_MIZYE/454-488             ...v-QCC...PLCQTTFEKGTTQMDIDGHIAVCLSMSGDDI..
A0A3L8S3H4_CHLGU/274-308             ....LDSC...PMCLMQFSGRLSQLDIDGHLARCLSESADDI..
L8YCL4_TUPCH/122-156                 ....LQSC...PMCQKEFHPGLAQLDMDSHLAQCLAESTED-l.
#=GC SS_cons                         ....-SBE...TTTTEB--TT--HHHHHHHHHHHHHHSSS--..
#=GC seq_cons                        ....LpSC...PMCQtpFsspLoQLDlDSHLAQCLAEST-DV..
//
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