GenomeNet

Database: Pfam
Entry: UL141
LinkDB: UL141
Original site: UL141 
#=GF ID   UL141
#=GF AC   PF16758.6
#=GF DE   Herpes-like virus membrane glycoprotein UL141
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   pdb_4i9x
#=GF GA   35.00 35.00;
#=GF TC   35.30 57.20;
#=GF NC   34.20 30.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Immunoglobulin_V-set_domain
#=GF RN   [1]
#=GF RM   23555243
#=GF RT   Structure of human cytomegalovirus UL141 binding to TRAIL-R2
#=GF RT   reveals novel, non-canonical death receptor interactions.
#=GF RA   Nemcovicova I, Benedict CA, Zajonc DM;
#=GF RL   PLoS Pathog. 2013;9:e1003224.
#=GF DR   INTERPRO; IPR031918;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   UL141 is a family of glycoproteins from herpesvirus species. At
#=GF CC   it N-terminus it carries an Ig-like beta-sandwich domain, which
#=GF CC   binds to the cysteine-rich region of TRAIL-R2, a family of
#=GF CC   tumour necrosis factor receptor proteins. UL141 is both
#=GF CC   necessary and sufficient to retain TRAIL receptors in the ER,
#=GF CC   thereby preventing their cell surface expression and it is also
#=GF CC   necessary and sufficient to inhibit cell surface expression of
#=GF CC   CD155 [1].
#=GF SQ   16
#=GS I3WF45_9BETA/35-227       AC I3WF45.1
#=GS A0A0K1GZN8_9BETA/102-291  AC A0A0K1GZN8.1
#=GS G8XT87_SCMVC/38-231       AC G8XT87.1
#=GS Q7TFU8_RHCM6/35-227       AC Q7TFU8.1
#=GS A0A0K1GZS0_9BETA/35-227   AC A0A0K1GZS0.1
#=GS UL14_HCMVA/48-234         AC P16756.2
#=GS UL14_HCMVM/48-234         AC Q6SWB7.1
#=GS Q8QS73_9BETA/52-238       AC Q8QS73.1
#=GS I3WF29_9BETA/102-291      AC I3WF29.1
#=GS Q8QRX2_9BETA/58-274       AC Q8QRX2.1
#=GS G8XTJ5_SCMVC/38-227       AC G8XTJ5.1
#=GS Q7TFH8_RHCM6/102-291      AC Q7TFH8.1
#=GS UL141_HCMVM/51-241        AC Q6RJQ3.1
#=GS UL141_HCMVM/51-241        DR PDB; 4I9X A; 51-241;
#=GS UL141_HCMVM/51-241        DR PDB; 4JM0 B; 51-241;
#=GS UL141_HCMVM/51-241        DR PDB; 4JM0 A; 51-241;
#=GS UL141_HCMVM/51-241        DR PDB; 4I9X B; 51-241;
#=GS G8XU86_9BETA/44-225       AC G8XU86.1
#=GS A0A0F7CSU8_SCMVC/105-294  AC A0A0F7CSU8.1
#=GS A0A0F7G9E3_SCMVC/39-232   AC A0A0F7G9E3.1
I3WF45_9BETA/35-227                  .v-SAPLMPPYGDRFNLTCDFPTGDWSEAALQIRFCYHP..SCRSFLMVTPKDiNGEFKNKSDNHLP.ELQ......WKLETVGPVQR.LTVSFLVVSSVSGIYRCTILTGINIEVLKTVIIIADVELRRRPDT-YCDIRFSHLSQLQYLWTPNPDKVRLLNCGEVR..ERns.lwQKHVH..YAVGMS..........G.....---LEPSC.T.VNrDMVLCH------ryvaes........
A0A0K1GZN8_9BETA/102-291             ..SPAPLIMPIGSQVTVPCAFLPHSWPMVSIRARFCQSE..YGGYELKINATN.GTAVDDDLTHRLI.NAS......WKFHDLAISHY.VTLTMNISDNTTGMFDCVLRNATHGFLTSRFTIVTQIETLHRPGDPDCAPKLGFHADGKKIWSSEYNEWQRHQCGTFY..GF.....DRLYY..YLAANN..........Q.....-SNTKPPC.P.PS.EPDRCWPVLQQY..............
G8XT87_SCMVC/38-231                  .v-SAPLMPPYGDRFDLTCEFPTGGWQEAALQIRFCHHP..GCRSLLMVNPRDvTGQFQNKNHEYLP.ELQ......WKMETDGPVQR.LTVSFVVTSSVSGVYQCTVANGLTMEVLKTMVIISEVELRRRPHV-YCDIRFGHRSQIRYLWTPDPEKVRLVNCGEVR..GN.....VRNTWhkHLHYAV..........G.....ESGLQPSC.S.MDrDMSLCHR-----yvfes.........
Q7TFU8_RHCM6/35-227                  .v-SAPLMPPYGDRFNLTCDFPTGDWSEAALQIRFCYHP..SCRSFLMVTPKDiNGEFKNKSDNHLP.ELQ......WKLETVGPVQR.LTVSFLVVSSVSGIYRCTILTGINIEVLKTVIIIADVELRRRPDT-YCDIRFSHLSQLQYLWTPNPDKVRLLNCGEVR..ERns.lwQKHVH..YAVGMS..........G.....---LEPSC.T.VNrDMVLCH------ryvaes........
A0A0K1GZS0_9BETA/35-227              .v-SAPLMPPYGDRFNLTCDFPTGDWSEAALQIRFCYHP..SCRSFLMVTPKDiNGEFKNKSDNHLP.ELQ......WKLETVGPVQR.LTVSFLVVSSVSGIYRCTILTGINIEVLKTVIIIADVELRRRPDT-YCDIRFSHLSQLQYLWTPNPDKVRLLNCGEVR..ERns.lwQKHVH..YAVGMS..........G.....---LEPSC.T.VNrDMVLCH------ryvaes........
UL14_HCMVA/48-234                    ..PGSPQLLPYGDRLEVACIFPAHDWPEVSIRVHLCYWP..EIVRSLVVDARS.GQVLHNDASCYIA.GGR......WRFEDGGAAQR.LSLSFRLITETAGTYTCVLGNETHSLATETTALVADVHDLRHSDR-SCDLAFGSRSQTRYLWTPDPSRLRSINCGWEG..ER.....HRVVH..YIPGTS..........G.....---LLPSC.E.ED.ERELCVPFISQS..............
UL14_HCMVM/48-234                    ..PGSPQLLPYGDRLEVACIFPAHDWPEVSIRVHLCYWP..EIVRSLVVDARS.GQVLHNDASCYIA.GGR......WRFEDGGAAQR.LSLSFRLITETAGTYTCVLGNETHSLATETTALVADVHDLRHSDR-SCDLAFGSRSQTRYLWTPDPSRLRSINCGWEG..ER.....HRVVH..YIPGTS..........G.....---LLPSC.E.ED.ERELCVPFISQS..............
Q8QS73_9BETA/52-238                  .l-SSPKMLPYGDRLDVSCIFPSHAWPEVSIHVRLCYWP..EIVRSLVVDAHS.GQLLHNDVTCQIS.SGR......WSFEDGGAAQT.LTLSFRLITQTAGTYHCVLGNETHGVVTESTALVADVHELQKTDR-SCDLAFGSRTQTKYLWTPDPSKLRSRDCGWEG..ER.....HRLVH..YIPGSS..........G.....---EEPSC.E.EN.EHQLCVPFIWK-s.............
I3WF29_9BETA/102-291                 ..SPAPLIMPIGSQVTVPCAFLPHSWPMVSIRARFCQSE..YGGYELKINATN.GTVVDDDLTYRLI.NAS......WKFHDLAISHY.VTLTMNISDNTTGMFDCVLRNATHGFLMTRFTIVTQIETLHRLGDPDCAPKLGFHADGKKIWSAEYNEWQRHQCGTFY..GF.....DRLYY..YLAASN..........Q.....-SNTKPPC.P.PS.EPDRCWPVLQQY..............
Q8QRX2_9BETA/58-274                  ..SPAPMLVAEGERVTVPCTVMIHQWPLAVIRATFCLSPptERSVELVFNLSR.GGEVVVPLEEKLT.ESRlrggvsYNFTDLHVAHL.FSLTFRATASSAGVYECLLRNDSHALVLQRFVVLTHLETLSWADEPCCTPPLGRHSQDRQIWSPTPWRLKHVDCGWSSqmGF.....RRNRF..YIEPASigdgteinidAgegedEECWGPLCqP.EE.QPDRCWPVVRQY..............
G8XTJ5_SCMVC/38-227                  ..SPAPLIMPLGSRITVPCTFLPHSWPMISIRARFCQSE..YAGYELVVNVTN.GTLDTDGLTSLLH.NAS......WKFVDMTLGHS.VSLSFNITDNTTGMFDCLLRNETHGYMTTRFTVITQIETLHRPGEIECVPKLGLRPDGDKIWTTEYNEWQRHNCGTFY..GF.....DRLYY..YLAATN..........K.....-SNTKPPC.P.PN.EPDRCWPVVQRY..............
Q7TFH8_RHCM6/102-291                 ..SPAPLIMPIGSQVTVPCAFLPHSWPMVSIRARFCQSE..YGGYELKINATN.GTVVDDDLTYRLI.NAS......WKFHDLAISHY.VTLTMNISDNTTGMFDCVLRNATHGFLMTRFTIVTQIETLHRPGDPDCAPKLGFHADGKKIWSAEYNEWQRHQCGTFY..GF.....DRLYY..YLAASN..........Q.....-SNTKPPC.P.PS.EPDRCWPVLQQY..............
UL141_HCMVM/51-241                   ..SPAPVLVAEGEQVTIPCTVMTHSWPMVSIRARFCRSH..DGSDELILDAVK.GHRLMNGLQYRLP.YAT......WNFSQLHLGQI.FSLTFNVSTDTAGMYECVLRNYSHGLIMQRFVILTQLETLSRPDEPCCTPALGRYSLGDQIWSPTPWRLRNHDCGMYR..GF.....QRNYF..YIGRAD..........A.....EDCWKPAC.P.DE.EPDRCWTVIQRY..............
#=GR UL141_HCMVM/51-241        SS    ..S---EE--TT-EEEEEEEEES-S-SEEEEEEEESSS-..-S-EEEEEETTT.--EEEECCCTT-T.T-E......EEEEE-SSEEE.EEEEEE--CCC-EEEEEEEE-SSEEEEEEEEEEESSEEE--------------S--SSSB-B-SSGGGEEEESSS---..--.....--EEE..EE----..........-.....--------.-.--.S--TTCCHHCCS..............
G8XU86_9BETA/44-225                  sv--GPLLAGHGEKISIPCFSHTTGQYMTGLYVVFCARH..--IQNAVLLFRN.GTKFLDTLSKHHArHGT......IVYHNSTAGTSfLQFSFTFEEKMAGRYNCLISNLTHTVVTTRFTLLDRVLSHRYRKYDVPNMVLPTHANTTQVWSAYPNKLHHLTCVTSK..HT.....IYDVF..YIYTAM..........S.....--------.-.--.------------tvscqhlskacrhl
A0A0F7CSU8_SCMVC/105-294             ..SPAPLIMPLGSQITIPCTFLPHSWPMVSIRARFCQSE..YAGHELMVNVTN.GTLVRDDLTGRLS.NAS......WSFVDLGLAHY.IALTLNVTNNTTAMFDCVLRNASHGRIEKRFTVITFVETLQRPGEPDCQPKLGFNADGDKIWTAGYNEWQRHTCGTFY..GF.....DRVFY..YLATTN..........R.....-SNHKPPC.P.PS.APDRCWPVVQQY..............
A0A0F7G9E3_SCMVC/39-232              .v-SAPTMPPYGDRFNLTCEFPTGGWTEAAVQIRFCNTP..NCRSLLLVNSKQiTGEFQNKSHEQLQ.GLR......WKLETEGPVQR.LTVSFLVTSNVSGIYQCAIVNNMDVDVLKTTVVISEVELRRRPHV-YCDLQFGEQSQTQYLWTPDPEKVRLVNCGEVG..GLvkntwHKHLH..YAVGNS..........G.....---MQPPC.DlER.DMSLCH------ryvfas........
#=GC SS_cons                         ..S---EE--TT-EEEEEEEEES-S-SEEEEEEEESSS-..-S-EEEEEETTT.--EEEECCCTT-T.T-E......EEEEE-SSEEE.EEEEEE--CCC-EEEEEEEE-SSEEEEEEEEEEESSEEE--------------S--SSSB-B-SSGGGEEEESSS---..--.....--EEE..EE----..........-.....--------.-.--.S--TTCCHHCCS..............
#=GC seq_cons                        ...sAPLlhPhG-RlslsCsF.sHuWP.suI+sRFChp...tssppLhVssps.Gshhcschsp+Ls.pup......W+Fcshusupp.loLSFplsssooGhYcClLtNsoHuhlhpphsllscVEsL+RPcc.sCs.phGp+opschlWTPsPs+l+phsCGpht..th.....cRhha..Ylsuss..........u........hcPsC.s..s.-.shCashl.p...............
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