GenomeNet

Database: Pfam
Entry: Uroplakin_II
LinkDB: Uroplakin_II
Original site: Uroplakin_II 
#=GF ID   Uroplakin_II
#=GF AC   PF07353.13
#=GF DE   Uroplakin II
#=GF AU   Vella Briffa B;0000-0003-4380-1783
#=GF SE   Pfam-B_19993 (release 10.0)
#=GF GA   20.40 21.30;
#=GF TC   20.40 21.50;
#=GF NC   20.20 20.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   8175808
#=GF RT   Mammalian uroplakins. A group of highly conserved urothelial
#=GF RT   differentiation-related membrane proteins. 
#=GF RA   Wu XR, Lin JH, Walz T, Haner M, Yu J, Aebi U, Sun TT; 
#=GF RL   J Biol Chem 1994;269:13716-13724.
#=GF DR   INTERPRO; IPR009952;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family contains uroplakin II, which is approximately 180
#=GF CC   residues long and seems to be restricted to mammals. Uroplakin
#=GF CC   II is an integral membrane protein, and is one of the components
#=GF CC   of the apical plaques of mammalian urothelium formed by the
#=GF CC   asymmetric unit membrane - this is believed to play a role in
#=GF CC   strengthening the urothelial apical surface to prevent the cells
#=GF CC   from rupturing during bladder distension [1].
#=GF SQ   111
#=GS A0A2K6P7V1_RHIRO/6-184    AC A0A2K6P7V1.1
#=GS A0A2K5LNW4_CERAT/6-184    AC A0A2K5LNW4.1
#=GS A0A3Q0FRA6_ALLSI/39-219   AC A0A3Q0FRA6.1
#=GS F7GA53_MONDO/6-184        AC F7GA53.1
#=GS A0A151P6U3_ALLMI/161-237  AC A0A151P6U3.1
#=GS A0A1S2ZS34_ERIEU/3-181    AC A0A1S2ZS34.1
#=GS A0A151P6V4_ALLMI/75-231   AC A0A151P6V4.1
#=GS A0A1U7SJL9_ALLSI/161-236  AC A0A1U7SJL9.1
#=GS A0A2R9BQ09_PANPA/6-184    AC A0A2R9BQ09.1
#=GS A0A3Q7THK3_VULVU/6-184    AC A0A3Q7THK3.1
#=GS A0A384C028_URSMA/6-185    AC A0A384C028.1
#=GS A0A2U3WTP8_ODORO/6-184    AC A0A2U3WTP8.1
#=GS A0A3Q7W947_URSAR/6-185    AC A0A3Q7W947.1
#=GS A0A384C046_URSMA/6-80     AC A0A384C046.1
#=GS F7APY6_HORSE/6-185        AC F7APY6.1
#=GS H0UY15_CAVPO/6-184        AC H0UY15.1
#=GS G3SVK2_LOXAF/6-184        AC G3SVK2.1
#=GS L5KKH5_PTEAL/6-173        AC L5KKH5.1
#=GS A0A1L8FLH9_XENLA/1-148    AC A0A1L8FLH9.1
#=GS A0A3Q0FQ87_ALLSI/71-250   AC A0A3Q0FQ87.1
#=GS A0A3B3TFM2_9TELE/3-172    AC A0A3B3TFM2.1
#=GS A0A384C041_URSMA/114-247  AC A0A384C041.1
#=GS A0A2U3ZT64_ODORO/6-185    AC A0A2U3ZT64.1
#=GS A0A096MPN2_PAPAN/6-184    AC A0A096MPN2.1
#=GS G3VC76_SARHA/7-142        AC G3VC76.1
#=GS A0A402E7V3_9SAUR/8-151    AC A0A402E7V3.1
#=GS A0A2Y9M9Z1_DELLE/6-185    AC A0A2Y9M9Z1.1
#=GS W5M5V0_LEPOC/9-187        AC W5M5V0.1
#=GS J9P8M3_CANLF/6-184        AC J9P8M3.1
#=GS B3DIH0_DANRE/36-115       AC B3DIH0.1
#=GS A0A2U3YZR5_LEPWE/6-184    AC A0A2U3YZR5.1
#=GS A0A2Y9KI65_ENHLU/6-185    AC A0A2Y9KI65.1
#=GS A0A340X8K7_LIPVE/6-185    AC A0A340X8K7.1
#=GS A0A2Y9E230_TRIMA/6-184    AC A0A2Y9E230.1
#=GS A0A1U7QAC9_MESAU/6-184    AC A0A1U7QAC9.1
#=GS UPK2_PIG/6-184            AC Q95L04.3
#=GS A0A3Q0FVR3_ALLSI/3-178    AC A0A3Q0FVR3.1
#=GS H0WVX2_OTOGA/6-185        AC H0WVX2.1
#=GS M3Y0J1_MUSPF/13-191       AC M3Y0J1.1
#=GS A0A1S3EMA2_DIPOR/6-184    AC A0A1S3EMA2.1
#=GS K7GHJ0_PELSI/166-245      AC K7GHJ0.1
#=GS A0A2K6V6S0_SAIBB/6-184    AC A0A2K6V6S0.1
#=GS A0A384C046_URSMA/112-178  AC A0A384C046.1
#=GS G5BHM8_HETGA/6-184        AC G5BHM8.1
#=GS A0A2K5ZRA9_MANLE/6-184    AC A0A2K5ZRA9.1
#=GS A0A384C1D2_URSMA/6-79     AC A0A384C1D2.1
#=GS A0A2K5I966_COLAP/6-184    AC A0A2K5I966.1
#=GS A0A2I3RKC4_PANTR/6-184    AC A0A2I3RKC4.1
#=GS A0A452SUX8_URSAM/6-184    AC A0A452SUX8.1
#=GS A0A384BAI4_BALAS/6-185    AC A0A384BAI4.1
#=GS A0A384C055_URSMA/6-184    AC A0A384C055.1
#=GS D4A0E6_RAT/6-184          AC D4A0E6.1
#=GS G1R726_NOMLE/2-149        AC G1R726.3
#=GS W5KJB5_ASTMX/126-224      AC W5KJB5.1
#=GS A0A310U5D5_XENLA/1-167    AC A0A310U5D5.1
#=GS UPK2_HUMAN/6-184          AC O00526.2
#=GS L9KJU9_TUPCH/6-184        AC L9KJU9.1
#=GS G1U4T8_RABIT/6-184        AC G1U4T8.1
#=GS M7B8E2_CHEMY/61-193       AC M7B8E2.1
#=GS A0A452GGE4_9SAUR/162-238  AC A0A452GGE4.1
#=GS A0A091E7E5_FUKDA/1-50     AC A0A091E7E5.1
#=GS G1P329_MYOLU/6-184        AC G1P329.1
#=GS A0A452DY99_CAPHI/6-185    AC A0A452DY99.1
#=GS Q3SXK0_MOUSE/6-184        AC Q3SXK0.1
#=GS F6VJ87_CALJA/6-184        AC F6VJ87.2
#=GS G3I984_CRIGR/5-182        AC G3I984.1
#=GS UPK2_BOVIN/6-185          AC Q08537.1
#=GS B5X967_SALSA/2-177        AC B5X967.1
#=GS A0A3B4CEV2_PYGNA/4-173    AC A0A3B4CEV2.1
#=GS A0A3B4CEI1_PYGNA/149-224  AC A0A3B4CEI1.1
#=GS I3MMP2_ICTTR/6-184        AC I3MMP2.1
#=GS A0A401QFY7_SCYTO/1-60     AC A0A401QFY7.1
#=GS A0A2U4BWH9_TURTR/93-167   AC A0A2U4BWH9.1
#=GS A0A151MWJ2_ALLMI/3-178    AC A0A151MWJ2.1
#=GS A0A401RFE4_CHIPU/5-180    AC A0A401RFE4.1
#=GS W5NIF2_LEPOC/135-227      AC W5NIF2.1
#=GS A0A2K6GGF8_PROCO/6-184    AC A0A2K6GGF8.1
#=GS A0A1U7UC84_TARSY/6-184    AC A0A1U7UC84.1
#=GS F1SAJ2_PIG/6-185          AC F1SAJ2.3
#=GS M7B7Q3_CHEMY/209-283      AC M7B7Q3.1
#=GS A0A2K6DID8_MACNE/6-184    AC A0A2K6DID8.1
#=GS A0A2K5CRI5_AOTNA/6-183    AC A0A2K5CRI5.1
#=GS UPK2_MOUSE/6-184          AC P38575.1
#=GS W5PQE8_SHEEP/6-185        AC W5PQE8.1
#=GS A0A2K5QJX1_CEBCA/6-184    AC A0A2K5QJX1.1
#=GS A0A1A6FY52_NEOLE/5-135    AC A0A1A6FY52.1
#=GS A0A2R8M6K7_CALJA/1-166    AC A0A2R8M6K7.1
#=GS A0A3Q7X4B3_URSAR/51-186   AC A0A3Q7X4B3.1
#=GS A0A1U8DD29_ALLSI/147-222  AC A0A1U8DD29.1
#=GS A0A3Q0HAK6_ALLSI/17-231   AC A0A3Q0HAK6.1
#=GS A0A060X7C0_ONCMY/76-254   AC A0A060X7C0.1
#=GS A0A2K5WC61_MACFA/6-184    AC A0A2K5WC61.1
#=GS A0A2K6L6F3_RHIBE/6-184    AC A0A2K6L6F3.1
#=GS G3R130_GORGO/6-184        AC G3R130.1
#=GS A0A384C041_URSMA/6-80     AC A0A384C041.1
#=GS A0A151P7Q7_ALLMI/18-231   AC A0A151P7Q7.1
#=GS M3WUK1_FELCA/6-184        AC M3WUK1.3
#=GS A0A455AYP5_PHYMC/49-177   AC A0A455AYP5.1
#=GS A0A0D9S3P7_CHLSB/6-184    AC A0A0D9S3P7.1
#=GS A0A1S3WC28_ERIEU/3-157    AC A0A1S3WC28.1
#=GS E2RQ03_CANLF/11-177       AC E2RQ03.2
#=GS A0A498NNM2_LABRO/314-394  AC A0A498NNM2.1
#=GS A0A401SEI5_CHIPU/143-225  AC A0A401SEI5.1
#=GS A0A3B1JTZ7_ASTMX/2-170    AC A0A3B1JTZ7.1
#=GS A0A2U4BWH9_TURTR/6-85     AC A0A2U4BWH9.1
#=GS A0A384C1D2_URSMA/113-246  AC A0A384C1D2.1
#=GS G1KZK6_AILME/6-184        AC G1KZK6.1
#=GS A0A452GGC5_9SAUR/160-230  AC A0A452GGC5.1
#=GS A0A2D0QCX5_ICTPU/2-170    AC A0A2D0QCX5.1
#=GS H2NFI6_PONAB/6-184        AC H2NFI6.1
#=GS A0A1L8GW18_XENLA/10-221   AC A0A1L8GW18.1
A0A2K6P7V1_RHIRO/6-184               .......................................................................................PIQTLPLILILLAVLSPG.T....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSSFVMPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.KK.GTATESSR...EI..PMSTLPRNNM..ESI....GLG.M...A...HTGGMVVITVLLSVSMFLLVLGFIIALALGARK................
A0A2K5LNW4_CERAT/6-184               .......................................................................................PIQTLPLILILLAVLSPG.I....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLTVRR..A..NDSKV...VKSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TQYYISYLV.KK.GTVTESSR...EI..PMSTFPRSNM..ESI....GLG.M...A...HTGGMVVITVLLSVTMFLLVLGFIIALALGAHK................
A0A3Q0FRA6_ALLSI/39-219              .....................................................................alamqalavltfcaffgg----------------TK.M....A.DFNIS....SV...S...GVLSPALAESLLMAVPPCQFTGANA.SIHIIH..P..NGTTD...VRH-FTVPLCRGRRELVSVVDSTG...GFTVTRLDAYQIT......R..............LTP.G.HTYTISYSVfNK.DRSVSKSN...SI..AMGTLNRVDY..RSI....PAD.M...S...RSGGMVVITVLLSIAMFVLVAGLIAMLAI----trck............
F7GA53_MONDO/6-184                   .......................................................................................PFPEKPFSLMLSVSLSCL.S....S.EFNIS....SL...S...GLLSPALAESLLVALPPCHLTGGKA.SLTVRR..V..NESAG...MTHNFTVPPCRARRDLVSVVYNSG...SFSITRLSAYQVT......N..............LIP.G.TKYFVYYSV.EK.GTAVESSN...KV..QMATLPRRKV..ETL....GLG.M...A...RTGGMIVITVLLSVAMFLLVVGLIVALALGVHK................
A0A151P6U3_ALLMI/161-237             ............................................ttyrfkyilvdetlgimkdetlwsdpiktnsvkksstidtwpg------------------.-....-.-----....--...-...-------------------------.------..-..-----...------------------------...-------------......-..............---.-.---------.--.--------...--..----------..---....---.-...R...RSGGMIVITSILSVLIFLLLAGLFASVFFA---vme.............
A0A1S2ZS34_ERIEU/3-181               ....................................................................................pll----LPLILILLAVLAPG.T...aA.DFNIS....SV...P...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VRSSFVVPPCRGRRDLVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYIV.MK.GASTESSR...EI..PMSTLPRRKV..DSI....GLG.M...A...RTGGMVVITVLLSVAMFVLVLGFIITLALGVRK................
A0A151P6V4_ALLMI/75-231              ............................................................tvglpavtdtnqirslrnftdapiyya------------------.-....-.-----....--...-...-------------------------.------..-..-----...--GEFASVSCRMARALVKMDIDDE...NYKLTTIVGYQVG......AevcentkgpfcnrvLKP.S.SFYRVNFFV.LD.ENAVVRAH...TD..WSDPIQTNNV..TSFsaydGSF.E...G...RAGGMIVITVLLSVGMFLVVVGLIVAAALG---dkt.............
A0A1U7SJL9_ALLSI/161-236             ............................................ttyrfkyilvdetlgimkdetlwsdpiktnsvkksstidtwpg------------------.-....-.-----....--...-...-------------------------.------..-..-----...------------------------...-------------......-..............---.-.---------.--.--------...--..----------..---....---.-...R...RSGGMIVITSILSVLIFLLLAGLFASVF-----fait............
A0A2R9BQ09_PANPA/6-184               .......................................................................................PIWTLPLILILLAVLSPG.A....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VTSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKFYISYLV.KK.GTATESSR...EI..PMSTLPRRKV..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGSRK................
A0A3Q7THK3_VULVU/6-184               .......................................................................................PVRTLPLILILLTVLALG.A....A.DFNIS....SV...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSSFVVPSCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.RK.GSSTESSR...EI..PMSTLPRRQA..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGLIIALALGARK................
A0A384C028_URSMA/6-185               .......................................................................................PVRTLRLILILLTVLALGaA....A.DFNIS....SI...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSQV...VKFSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......D..............LVP.G.TKYYISYLV.TK.GTSTESSR...EI..PMSTLPRRKV..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGARK................
A0A2U3WTP8_ODORO/6-184               .......................................................................................PVRTLTLILILLTVLALG.A....S.DFNIS....SV...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSQV...VKSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......D..............LVP.G.TKYYVSYLV.TK.GTSTESSR...EI..PMSTLPRRKV..ESI....GLG.M...A...RTGGMVVITVLLSVAMLLLVLGFIIALALGAQK................
A0A3Q7W947_URSAR/6-185               .......................................................................................PVRTLRLILILLTVLALGaA....A.DFNIS....SI...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSQV...VKFSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......D..............LVP.G.TKYYISYLV.TK.GTSTESSR...EI..PMSTLPRRKV..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGARK................
A0A384C046_URSMA/6-80                .......................................................................................PVRTLRLILILLTVLALGaA....A.DFNIS....SI...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSQG...L-----------------------...-------------......-..............---.-.---------.--.--------...--..----------..---....---.-...-...---------------------------------lpppkmap........
F7APY6_HORSE/6-185                   .......................................................................................PIRTLPLILILLAVMAPG.A....AvDFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.TK.GASTESSR...EI..PMSTLPRRKL..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVIGFIIALALGARK................
H0UY15_CAVPO/6-184                   .......................................................................................PVHTLPLTLILLALLAPG.A....T.EFNIS....SL...S...GVLSPALAESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VNSSFVVPPCRGRRDLVSVVDSGA...GFTVTRLSAYQVM......N..............LTP.G.TKYYISYRV.QK.GTSTESSR...EI..TMSTLPRRTV..ESI....RVG.M...A...RTGGMVVITVLLSVGMFILVLGLIITLALGAQK................
G3SVK2_LOXAF/6-184                   .......................................................................................PVWTLPLILILLAVLAPV.A....A.DFHIS....SL...S...GVLSPALTESLLVALAPCRLTGGNA.TLMVRR..A..NDSKV...VKSSFMVPPCRGHRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.KK.GTSTESSK...ES..AMSTLPRRKM..EST....GLG.M...A...RTGGMVVITVLLSVAMFLLVVGFITALALGAQK................
L5KKH5_PTEAL/6-173                   ................................................................................dlkeden------------------.Q....A.DFNIS....SL...S...GLLFPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSSFLVPPCRGRRELVSVVDSGA...SFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.TK.GTSTESSR...EI..PMSTLPRRKV..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLSFIIALALGAQK................
A0A1L8FLH9_XENLA/1-148               .....................................................................................nt------------------.-....-.----S....LA...D...GVLTP-LSTSVIIAFPGCKDSGKTV.NLIVAN..G..-TTTV...QNISLQVPQCRLKRDVVVINNSQS...GNVQTVNVGYQIQ......N..............LQP.G.AIYTTYYAV.D-.GSNI---P...SI..TFS--TRSVS..QTV....PDI.M...A...RSGGMVVITVLLSIAMFVLLVGLIAVLVIG---rk..............
A0A3Q0FQ87_ALLSI/71-250              ......................................................................lamqalavltfcaffgg----------------TK.M....A.DFNIS....SV...S...GVLSPALAESLLMAVPPCQFTGANA.SIHIIH..P..NGTTD...VRH-FTVPLCRGRRELVSVVDSTG...GFTVTRLDAYQIT......R..............LTP.G.HTYTISYSVfNK.DRSVSKSN...SI..AMGTLNRVDY..RSI....PAD.M...S...RSGGMVVITVLLSIAMFVLVAGLIAMLAI----trck............
A0A3B3TFM2_9TELE/3-172               ..........................................................................tlritafgvlltl-----------------A.Y....A.NFPLQ....LLd.sS...SVVTATFTDSVLLNVPPCSLAGQKV.SLTYQN.mA..NKSTV..tLQNVFAVPSCRNRRDLLDVTQSNG...QN-----LGYQVT......N..............LVS.G.TQYSFQYNV.GS.----NMSD...SL..QASTAQAVPY..STI....YDG.L..pA...RSGAMVVVTVILVILVFLLIVGLVLTVIY----ghc.............
A0A384C041_URSMA/114-247             .....................................................................lllgasgntpltsppisc------------------.-....-.-----....--...-...-------------------------.------..-..---PV...VKFSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......D..............LVP.G.TKYYISYLV.TK.GTSTESSR...EI..PMSTLPRRKV..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGARK................
A0A2U3ZT64_ODORO/6-185               .......................................................................................PVRTLTLILILLTVLALGaS....A.DFNIS....SV...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSQV...VKSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......D..............LVP.G.TKYYVSYLV.TK.GTSTESSR...EI..PMSTLPRRKV..ESI....GLG.M...A...RTGGMVVITVLLSVAMLLLVLGFIIALALGAQK................
A0A096MPN2_PAPAN/6-184               .......................................................................................PIQTLPLILILLAVLSPG.I....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLTVRR..A..NDSKV...VKSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.KK.GTATESSR...EI..PMSTLPRSNM..ESI....GLG.M...A...HTGGMVVITVLLSVTMFLLVLGFIIALALGAHK................
G3VC76_SARHA/7-142                   ..................................................................................afltp-----TLLLLVLLDLGAA.G....P.EFNIS....SI...S...GLLSPALAESFLVALPPCHLTGGKA.TLTVRR..T..NESTG...LTHNFMVPPCRGQRDLVNVVYSGG...SFTVTRLDAYQVT......N..............LVP.G.TSYYVSYSV.VK.GNAVESSN...RV..QMATLPR---..---....---.-...-...---------------------------------e...............
A0A402E7V3_9SAUR/8-151               .......................qnlrktpqatiyfagefksvscgvardlvlmetdngqyelftvlgfqvgaefcrqtkgpfcnqa------------------.-....-.-----....--...-...-------------------------.------..-..-----...------------------------...-------------......-..............LKP.S.TFYRVNFFLlDE.KSEIRGHT...DWspAIQTRNVTNY..DSV....DVA.Y...A..gRAGGMIVITILVSIGGLVLGIALIAAVVLSNKK................
A0A2Y9M9Z1_DELLE/6-185               .......................................................................................PVRTLSLILILLAVLAPG.A...aA.DFNVS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSSFVVPPCRGRRELVSVVDSGS...GFTVTRLSAYQMT......N..............LVP.G.TKYYISYVV.TK.GVSTESSR...EV..PMSTLPRRKA..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGAQK................
W5M5V0_LEPOC/9-187                   ...............................................................................mgalllaa----------LGLLLAAA.D....A.DFTVN....VLgesD...GLVTGQLSDSVILSLPPCSLAGNTV.NMVYQQ..GgtQNKVN...LTGIFKVPVCRFKRDLITVIANSG...QFTVTRNIGYQVK......N..............LSP.A.TNYTFQYFV.--.--GSEKSN...AV..QAATRTVSNY..QDI....DDG.L..pA...RSGAMVVITVLLSVAMFILIVGLIVTLVL----ahcr............
J9P8M3_CANLF/6-184                   .......................................................................................PVRTLPLILILLTVLALG.A....A.DFNIS....SV...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSSFVVPSCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.RK.GSSTESSR...EI..PMSTLPRRQA..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGLIIALALGARK................
B3DIH0_DANRE/36-115                  ....................................................................................vsq------------------.-....-.-----....--...-...-------------------------.------..-..-----...------------------------...-------SWYLLG......N..............LKN.G.TTYSMSYKI.GN.DTSSVLTN...TT..----TNVNDY..QQI....DTG.L..rA...RSGAMVVITVILSLAMVFLLVGIILV-------ffff............
A0A2U3YZR5_LEPWE/6-184               .......................................................................................PTRTLPLILILLTVLAPG.A....S.DFNIS....SV...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSQV...VKSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......D..............LVP.G.TKYYISYLV.TK.GTSTESSR...ET..PMSTLPRRKV..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIITLALGTRK................
A0A2Y9KI65_ENHLU/6-185               .......................................................................................PVQTWPLILILLTVLALGaA....A.DFNIS....SI...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSQV...VKSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.TK.GTSTESSR...EI..PMFTLPRRKV..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVVGFIIALALGARK................
A0A340X8K7_LIPVE/6-185               .......................................................................................PVLTLSLILILLAVLAPG.A...aA.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMARR..A..NDSKV...VKSSFVVPPCRGRRELVSVVDSGS...GFTVTRLSAYQMT......N..............LVP.G.TKYYISYLV.TK.GASTESSR...EV..PMSTLPRRKA..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIVLALGTQK................
A0A2Y9E230_TRIMA/6-184               .......................................................................................PVRTLPSILILLAVLAPA.A....V.DFNIS....SV...S...GVLSPALTESLLVALPSCHFTGGNA.TLMVRR..A..NDSKV...VKSSFVVPPCRGRRGLVTVVDSGA...GFTVTRLRAYQVT......N..............LVP.G.TKYYISYLV.KK.RTSTEYSK...EI..PMSTLSRRKM..ESI....GLG.M...A...RTGGMVVITVLLSIAMFLLVVGFIISLALGAQK................
A0A1U7QAC9_MESAU/6-184               .......................................................................................PVQTLPLFLILLAVLAPG.T....A.DFNIS....SL...S...GVLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSVFMVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LTP.G.TKYYISYRV.QK.GTFTESSP...ET..PMSTLPRRNM..ESI....SLG.M...A...RTGGMVVITVLLSVAMFLLVVGLIVALALGARK................
UPK2_PIG/6-184                       .......................................................................................PVRTLPLILILLAVLAPG.A....S.DFNIS....SL...S...GPLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSSFMVPPCRGRRELVSVVDSGS...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.TK.GASTESSR...EI..PMSTLPRKNM..EGI....GLG.M...A...RTGGMVVITVLLSVAMFLLVVGFITALALGARK................
A0A3Q0FVR3_ALLSI/3-178               .........................................................................alavltfcaffggt-----------------K.M....A.DFNIS....SV...S...GVLSPALAESLLMAVPPCQFTGANA.SIHIIH..P..NGTTD...VRH-FTVPLCRGRRELVSVVDSTG...GFTVTRLDAYQIT......R..............LTP.G.HTYTISYSVfNK.DRSVSKSN...SI..AMGTLNRVDY..RSI....PAD.M...S...RSGGMVVITVLLSIAMFVLVAGLIAMLAI----trck............
H0WVX2_OTOGA/6-185                   .......................................................................................PIRTMPLILILLAVLAPG.AaglpA.EFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VNSSFVVPPCRGRRELVSVVDSGA...GFTVTRLNAYQVT......N..............LVP.E.TKYYISYLV.KK.GPSTESSR...EI..SMS---RRNM..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGLIISLALGARK................
M3Y0J1_MUSPF/13-191                  .......................................................................................PVRTWPLILILLTVLALG.A....S.DFNIS....SI...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSQV...VKSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......D..............LVP.G.TKYYISYLV.TK.GTSTESSR...EI..PMSTLPRRKV..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVVGFIIALALGARK................
A0A1S3EMA2_DIPOR/6-184               .......................................................................................PIQTLPSILILLAILAPG.A....A.EFNIS....SL...S...GLLSPALAESLLVALPPCHLTGGNA.TLMVRR..A..NDSQV...VKSSFVVPPCRGRRDLVSVVDSGA...GFTVTRLSAYQVT......D..............LVP.G.TKYYISYQV.QK.GTTTESSR...EI..PMSTLPRKSM..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVVGLIIALALGVHK................
K7GHJ0_PELSI/166-245                 ...........................................................laqdttyrfkyllvdvnagvvkdqtlws------------------.-....-.-----....--...-...-------------------------.------..-..-----...------------------------...-------------......-..............---.-.---------.--.--------...-D..PMKTRRVKQS..STI....DTWpG...R...RSGGMIVITSILSTLMFILVAGFLASLYF----ivm.............
A0A2K6V6S0_SAIBB/6-184               .......................................................................................PIRTLPLILILLVVLSPG.V....A.EFNIS....SL...S...GLLSPVLSESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.KK.GTATESSR...EI..PMSTLPRSNM..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGARK................
A0A384C046_URSMA/112-178             ...................................................................aalllgasgntpltsppisc------------------.-....-.-----....--...-...-------------------------.------..-..---PV...VKFSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......D..............LVP.G.TKY------.--.--------...--..----------..---....---.-...-...---------------------------------................
G5BHM8_HETGA/6-184                   .......................................................................................PVHTLPLMLILLAILAPG.A....A.EFNIS....NL...S...GLLSPALAESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VNSSFVVPPCRGRRELVSVMDSGA...GFTVTRLSAYQVT......N..............LHP.G.TKYYISYQV.QK.GSSTESSQ...EI..PMSTLPQRNM..ESI....GLG.M...A...RTGGMVVITVLLSISMFVLVVGLIITLALGTRK................
A0A2K5ZRA9_MANLE/6-184               .......................................................................................PIQTLPLILILLAVLSPG.I....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLTVRR..A..NDSKV...VKSSFVVPPCHGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.KK.GTATESSR...EI..PMSTLPRSNM..ESI....GLG.M...A...HTGGMVVITVLLSVTMFLLVLGFIIALALGAHK................
A0A384C1D2_URSMA/6-79                .......................................................................................PVRTLRLILILLTVLALG.A....A.DFNIS....SI...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSQG...L-----------------------...-------------......-..............---.-.---------.--.--------...--..----------..---....---.-...-...---------------------------------lpppkmap........
A0A2K5I966_COLAP/6-184               .......................................................................................PIQTLPLILILLAVLSPG.T....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLTVRR..A..NDSKV...VKSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.KK.ETATESSR...EI..PMSTLPRSNM..ESI....GLG.M...A...HTGGMVVITVLLSVAMFLLVLGFIIALALGARK................
A0A2I3RKC4_PANTR/6-184               .......................................................................................PIRTLPLILILLAVLSPG.A....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VTSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKFYISYLV.KK.GTATESSR...EI..PMSTLPRRNV..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGSRK................
A0A452SUX8_URSAM/6-184               .......................................................................................PVRTLRLILILLTVLALG.A....A.DFNIS....SI...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSQV...VKFSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......D..............LVP.G.TKYYISYLV.TK.GTSTESSR...EI..PMSTLPRRKV..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGARK................
A0A384BAI4_BALAS/6-185               .......................................................................................PVRTLSLILILLAVLAPG.A...aA.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLIVRR..A..NDSKV...VKSSFVVPPCRGRRELVSVVDSGS...GFTVTRLSAYQMT......N..............LVP.G.TKYYISYLV.TK.GASTESSR...EV..PMSTLPRRKA..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGAQK................
A0A384C055_URSMA/6-184               .......................................................................................PVRTLRLILILLTVLALG.A....A.DFNIS....SI...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSQV...VKFSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......D..............LVP.G.TKYYISYLV.TK.GTSTESSR...EI..PMSTLPRRKV..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGARK................
D4A0E6_RAT/6-184                     .......................................................................................PVQTLRLFLILLAVLAPG.A....A.DFNIS....SL...S...GLLSPALTESLLIALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSGFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LTP.G.TKYYISYRV.QK.GMSTESSP...ET..PMSTLPRRNM..ESI....RLG.M...A...RTGGMVVITVLLSVAMFLLVVGLIIALALGAHK................
G1R726_NOMLE/2-149                   ..................................................................................csakt-------VILLLLSPSCL.P....S.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VTSSFVVPPCRGRRELVSVVDSGA...GFTVTRLGAYQVT......N..............LVP.G.TKYYISYLV.KK.GTATESSR...EI..PMSTLPR-NV..EGL....G--.Q...T...RMR------------------------------kmvw............
W5KJB5_ASTMX/126-224                 ...................................................................gyfrvgadgacsttncngfl------------------.-....-.-----....--...-...-------------------------.------..-..-----...------------------------...-----------PQ......G..............SSP.S.FKYLLVDSV.NK.TVLAETKW...SD..SIALYTLKDP..GTL....GDG.F...A..gRSGAMVVITTLLSVAAAVLLLFLIVVLAL----ccc.............
A0A310U5D5_XENLA/1-167               ............................................................................mqllgisvvll--------------LISG.A....I.AQNTS....LA...D...GVLTP-LSTSAIIAFPACNYSGLSV.FLIVKN..S..-TVTV...QNVSFQVPQCRLKRDVVVVNNLQS...GNVQTVNVGYQLQ......N..............LQP.G.TIYTAYYSY.GE.NT----IP...ST..QFST--RTVS..QTV....PDI.M...A...RSGGMVVITVLLSIAMFVLVVGLIAVIV-----tgrk............
UPK2_HUMAN/6-184                     .......................................................................................PIRTLPLILILLALLSPG.A....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VTSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKFYISYLV.KK.GTATESSR...EI..PMSTLPRRNM..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGSRK................
L9KJU9_TUPCH/6-184                   .....................................................................................pg--RTSPRILILLALLAPG.A....A.DFNIS....SL...S...GLLSPVLTESLLVALPPCHLTGGNA.TLTVRR..A..NDSKV...VKSSFEVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LAP.G.TKYYISYMV.KK.GSATESSR...EV..PMSTLPRNSV..ESI....SLG.M...A...RTGGMVVITVLLSVAMFVLILGFIIALALGARK................
G1U4T8_RABIT/6-184                   .......................................................................................PVWTLPSILVLLAALAPG.A....A.DFNIS....GL...T...GLLSPALTESLLVALPPCHLTGGNA.TLRVRR..A..NDSQV...VKSSFVVPPCRGRRELVSVVDSGA...GFVVTRLSAYQVT......N..............LVP.G.TKYYVSYLV.AK.GTSAESSR...EV..PMSTLPRRNV..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVVGFITALVLGARK................
M7B8E2_CHEMY/61-193                  ...................................................................................srvs---------------SIV.L....S.DFNIS....SF...S...SVLFLAFAESFLMAVPLCQFTGAHA.SIHITH..L..DGTTD...IRH-FTVPPCCGRHDLVNLMDSNG...GFTLTRLDAYQVT......N..............LVLtGsLALSISYSI.PKkDPSRSTSN...TV..TTVTLER---..---....---.-...-...---------------------------------yaagvgy.........
A0A452GGE4_9SAUR/162-238             ..............................................................ttyrfkyllvdlvagvvkdqtlwsd------------------.-....-.-----....--...-...-------------------------.------..-..-----...------------------------...-------------......-..............---.-.---------.--.--------...--..PMKTRRVKQT..STI....DTWpG...R...RSGGMIVITSILSTLIFLLVVGFLASIF-----ffvma...........
A0A091E7E5_FUKDA/1-50                .......................................................................................------------------.-....-.-----....--...-...-------------------------.------..-..-----...------------------------...-------------......-..............---.-.---------.--.--------...--..-MSTLPRRNM..ESI....GLG.M...A...RTGGMVVITVLLSVSMFVLVVGLIVTLILGAQK................
G1P329_MYOLU/6-184                   .......................................................................................PSRTLPLTLVLMVVLDPG.A....A.VFNIS....SL...S...GLLSPALAESLLVALPPCHLTGGNA.TLMVRR..A..NDSTV...VTAGFVVPPCRGRRELVSVVDSGA...GFTVTRLRAYQVT......N..............LAP.G.TKYYVSYRV.QK.GTATESSR...EV..PMSTLPRRKG..ASI....GLG.M...A...RTGGMVVITVLLSVAMFLLVVGFIVALALGARK................
A0A452DY99_CAPHI/6-185               .......................................................................................PVRTLSWILILLAVLAPG.A...aA.DFNIS....SL...S...GLLSPVMTESLLVALPPCHLTGGNA.TLTVRR..A..NDSKV...VRSSFVVPLCRGRRELVSVVDSGS...GFTVTQLSAYQVT......N..............LAP.G.TKYYVSYLV.TK.GASTESSR...EI..PMSTLPRRKA..ESI....GLA.M...A...RTGGMVVITVLLSVAMFLLVLVLIIALVLGARK................
Q3SXK0_MOUSE/6-184                   .......................................................................................PVQTLPLILILLAVLAPG.T....A.DFNIS....SL...S...GLLSPALTESLLIALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSDFVVPPCRGRRELVSVVDSGS...GYTVTRLSAYQVT......N..............LTP.G.TKYYISYRV.QK.GTSTESSP...ET..PMSTLPRKNM..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVVGLIVALALGARK................
F6VJ87_CALJA/6-184                   .......................................................................................PIRTLPLILILLAVLSPG.V....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLTVRR..A..NDSKV...VKSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.KK.GTATESSR...EV..PMSTLPRRNM..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGARK................
G3I984_CRIGR/5-182                   ......................................................................................lPVQTLPL--ILLAVLAPG.A....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSVFMVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LTP.G.TKYYISYRV.QK.GTSTESSP...ET..PMSTLPRRNM..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVVGLIVALALGARK................
UPK2_BOVIN/6-185                     .......................................................................................PVWTLSWILILLAVLVPG.A...aA.DFNIS....SL...S...GLLSPVMTESLLVALPPCHLTGGNA.TLTVRR..A..NDSKV...VRSSFVVPPCRGRRELVSVVDSGS...GFTVTRLSAYQVT......N..............LAP.G.TKYYISYLV.TK.GASTESSR...EI..PMSTFPRRKA..ESI....GLA.M...A...RTGGMVVITVLLSVAMFLLVLGLIIALALGARK................
B5X967_SALSA/2-177                   ..............................................................................rtmfiffgi-------------LFTLS.N....A.EFQVS....LLkesD...GVVTGRFADSLLLSLPPCALATQSV.TLEYNNtdT..NESKT...LVNIFKVLPCRFRRDIISTIENNA...QFTTSRNLGYQVT......N..............LTT.G.STYRFQYVV.--.--GAEKSN...IL..EVSTRQVKDH..NQI....DSG.L..pA...CSGAMMVTTVILSVSMFILLVALIFTVA-----hslg............
A0A3B4CEV2_PYGNA/4-173               ........................................................................emlavlfilggfvpl-----------------I.D....A.DFVLR....VL...TtedGVLTGRFPDSLLLSLPPCNYSGQSV.DLEYLN..VntNEYKT...LSNIFTVNCTNG-------ISTAG...SAALSRNLGYQVT......N..............LTN.G.TEYKFHYKI.G-.--ATNSSY...-V..LATTRRVFDY..NGI....DEG.L..pA...RSGAMVVITVILSLAMFFLLICLILS-------tvmst...........
A0A3B4CEI1_PYGNA/149-224             .......................................................stasfkyllvdpasktllaetkwsdnitlyts------------------.-....-.-----....--...-...-------------------------.------..-..-----...------------------------...-------------......-..............---.-.---------.--.--------...--..-------KDP..GSI....SDS.F...A..gRSGAMVVITAILSVAMALLLLLLIIAVAL----ccc.............
I3MMP2_ICTTR/6-184                   .......................................................................................PVQTLPLILILLAILAPG.A....A.EFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLTVRR..A..NDSKV...EKSSFIVPPCRGRRELVSVVDSGN...GFTVTRLRAYQVT......N..............LLP.G.TKYYISYRV.EK.GTSTESSR...EI..PMSTLPRRNM..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVVGFIIALALGARK................
A0A401QFY7_SCYTO/1-60                .........................................................................aftvivtnssggpg------------------.-....-.-----....--...-...-------------------------.------..-..----P...VQSGFTRPICRFRRGLINLISNAN...GISTTLNLGYRVT......N..............LKP.A.TGY------.--.--------...--..----------..---....---.-...-...---------------------------------................
A0A2U4BWH9_TURTR/93-167              .......................................................................tqemlrkcvfdgcldp------------------.-....-.-----....--...-...-------------------------.------..-..-----...------------------------...-------------......-..............---.-.---------.--.--SNESLQ...RP..PSSLLTGRKA..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGAQK................
A0A151MWJ2_ALLMI/3-178               .........................................................................alavltfcaffggt-----------------K.M....A.DFNIS....SV...S...GVLSPALAESLLMAVPPCQFTGANA.SIHIIH..P..NGTTD...VRH-FTVPLCRGRRELVSVVDSTG...GFTVTRLDAYQIT......R..............LTP.G.HTYTISYSVfNK.DRSVSKSN...SI..AMGTLNRVDY..RSI....PAD.T...S...RSGGMVVITVLLSIAMFVLVAGLIAMLAI----trck............
A0A401RFE4_CHIPU/5-180               ...........................................................................fvtviplrlnrl---------------DTP.I....A.AFNISlankAD...N...GIVGSVRSMSAIVNLPQCRFSNQEV.--MVNV..T..NNTGGpgpEQKSFDNPICRFKRGLISIVSNAN...DVRQTLNLGYKLT......N..............LQP.N.TEYDVVYRI.G-.--S-EESN...PL..RIMTSSPMDF..NNI....DVG.F...S..gRSGAMVVITVLLSIAMVVLIIILIVSV------fvrt............
W5NIF2_LEPOC/135-227                 ....................................................................eylvrigsnptcvgepeae------------------.-....-.-----....--...-...-------------------------.------..-..-----...------------------------...--------AFCNA......P..............LSD.G.TSYRFKYLL.VN.GTTTIAET...EW..SESILTRKALspDEI....DTW.I..gK...RSGGGIVVTVILSLLLFLLL-------------ga..............
A0A2K6GGF8_PROCO/6-184               .......................................................................................PIHTMPLILILLAVLAPG.A....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSSFVVPPCRGRRELVSVVDSGA...GFTVTRLGAYQVT......N..............LVP.G.TKYYVSYLV.KK.GTSTESSG...EV..PMSTLPRRNM..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGLIIALALGARK................
A0A1U7UC84_TARSY/6-184               .....................................................................................sv--CSLPSILILLAVLAPG.A....A.EFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSSFVVPPCRGRRELVSVVDSGA...GFTVSRLSAYQVT......N..............LVP.G.TKYYISYLV.KK.GASTESSR...EV..PMSTLPRKNM..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVVGFIVALALGARK................
F1SAJ2_PIG/6-185                     .......................................................................................PVRTLPLILILLAVLAPGaS....A.NFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSSFMVPPCRGRRELVSVVDSGS...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.TK.GASTESSR...EI..PMSTLPRRKA..EAI....GLG.M...A...RTGGMVVITVLLSVAMFLLVVGFITALALGARK................
M7B7Q3_CHEMY/209-283                 .............................................tyrfkyllvdvvagvvkdqtlwsdpmktsrvkqpstidtwpg------------------.-....-.-----....--...-...-------------------------.------..-..-----...------------------------...-------------......-..............---.-.---------.--.--------...--..----------..---....---.-...R...RSGGMIVITSVLSTLMFLLVVGFLASI------fffvi...........
A0A2K6DID8_MACNE/6-184               .......................................................................................PIQTLPLILILLAVLSPG.T....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLTVRR..A..NDSKV...VKSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.KK.GTATESSR...EI..PMSTLPRSNM..ESI....GLG.M...A...HTGGMVVITVLLSVTMFLLVLGFIIALALGAHK................
A0A2K5CRI5_AOTNA/6-183               .......................................................................................PIQTLPLILILLAVLSPG.V....A.DFNIS....SL...S...GLLSPALTESLLIALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.KK.GTATESSR...EI..PMSTLPRRNM..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIISLALGAR-................
UPK2_MOUSE/6-184                     .......................................................................................PVQTLPLILILLAVLAPG.T....A.DFNIS....SL...S...GLLSPALTESLLIALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSDFVVPPCRGRRELVSVVDSGS...GYTVTRLSAYQVT......N..............LTP.G.TKYYISYRV.QK.GTSTESSP...ET..PMSTLPRKNM..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVVGLIVALHWDARK................
W5PQE8_SHEEP/6-185                   .......................................................................................PVRTLSWILILLAVLAPG.A...aA.DFNIS....SL...S...GLLSPVMTESLLVALPPCHLTGGNA.TLTVRR..A..NDSKV...VRSSFVVPPCRGRRELVSVVDSGS...GFTATRLSAYQVT......N..............LAP.G.TKYYISYLV.TK.GASTESSR...EI..PMSTLPRRKA..ESI....GLA.M...A...RTGGMVVITVLLSVAMFLLVLGLIIAVVLGTRK................
A0A2K5QJX1_CEBCA/6-184               .......................................................................................PIRTLPMILILLVVLSPG.V....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...MKSSFVVPSCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.KK.GTATESSR...EI..PMSTLPRRNM..ESI....GLA.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGARK................
A0A1A6FY52_NEOLE/5-135               .......................................................................dlrvrltpsafppdfl------------------.-....T.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSVFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LTP.G.TKYYISYRV.QK.GTSTESSP...ET..PMSTLP----..---....---.-...-...---------------------------------................
A0A2R8M6K7_CALJA/1-166               .....................................................................................ap---------------SCL.P....S.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLTVRR..A..NDSKV...VKSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.KK.GTATESSR...EV..PMSTLPRRNM..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGARK................
A0A3Q7X4B3_URSAR/51-186              ...................................................................aalllgasgntpltsppisc------------------.-....-.-----....--...-...-------------------------.------..-..---PV...VKFSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......D..............LVP.G.TKYYISYLV.TK.GTSTESSR...EI..PMSTLPRRKV..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGARK................
A0A1U8DD29_ALLSI/147-222             ............................................ttyrfkyilvdetlgimkdetlwsdpiktnsvkksstidtwpg------------------.-....-.-----....--...-...-------------------------.------..-..-----...------------------------...-------------......-..............---.-.---------.--.--------...--..----------..---....---.-...R...RSGGMIVITSILSVLIFLLLAGLFASVF-----fait............
A0A3Q0HAK6_ALLSI/17-231              ...wavqlssldkislnffpnmsnilaarlsssfivnipkcissshytpttirpaiavlgetvglpavtdtnqirslrnftdapiyy------------------.-....-.-----....--...-...-------------------------.------..-..-----...-AGEFASVSCRMARALVKMDIDDE...NYKLTTIVGYQVG......AevcentkgpfcnrvLKP.S.SFYRVNFFV.LD.ENAVVRAH...TD..WSDPIQTNNV..TSFsaydGSF.E...G...RAGGMIVITVLLSVGMFLVVVGLIVAAALGGRK................
A0A060X7C0_ONCMY/76-254              ...........................................................................tamrtmfiffgm-------------LFTLS.N....A.EFQVS....LLkesD...GVVTGRFADSLLLSLPPCALATQSV.TLEYNNtdT..NESKT...LVNIFKVLPCRFRRDIISNIENNG...QFTTSRNLGYQVT......N..............LTT.G.STYRLQYVV.--.--GAEKSN...IL..EVSTRQVKDP..NQI....DSG.L..pA...RSGAMVVITVILSVSMFILLVALIVTVAH----slg.............
A0A2K5WC61_MACFA/6-184               .......................................................................................PIQTLPLILILLVVLSPG.T....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLTVRR..A..NDSKV...VKSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.KK.GTATESSR...EI..PMSTLPRSNM..ESI....GLG.M...A...HTGGMVVITVLLSVTMFLLVLGFIIALALGAHK................
A0A2K6L6F3_RHIBE/6-184               .......................................................................................PIQTLPLILILLAVLSPG.T....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSSFVMPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.KK.GTATESSR...EI..PMSTLPRNNM..ESI....GLG.M...A...HTGGMVVITVLLSVSMFLLVLGFIIALALGARK................
G3R130_GORGO/6-184                   .......................................................................................PIRILPLILILLAVLSPG.A....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VTSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKFYISYLV.KK.GTATESSR...EI..PMSTLPRRNM..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGSRK................
A0A384C041_URSMA/6-80                .......................................................................................PVRTLRLILILLTVLALGaA....A.DFNIS....SI...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSQG...L-----------------------...-------------......-..............---.-.---------.--.--------...--..----------..---....---.-...-...---------------------------------lpppkmap........
A0A151P7Q7_ALLMI/18-231              ....avqfssldkislnffpnmsnilaarlsssfivnipkcissshytpttirpaiavlgetvglpavtdtnqirslrnftdapiyy------------------.-....-.-----....--...-...-------------------------.------..-..-----...-AGEFASVSCRMARALVKMDIDDE...NYKLTTIVGYQVG......AevcentkgpfcnrvLKP.S.SFYRVNFFV.LD.ENAVVRAH...TD..WSDPIQTNNV..TSFsaydGSF.E...G...RAGGMIVITVLLSVGMFLVVVGLIVAAALG---dkt.............
M3WUK1_FELCA/6-184                   .......................................................................................PFRTLPLNLILLTVLALG.A....A.DFNIS....SV...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSSFMVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LAP.G.TKYYVSYLV.TK.GASTESSR...EI..PMSTLPRRKM..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVVGFIIALALGARK................
A0A455AYP5_PHYMC/49-177              ........................................................................tdgairevvsllhfl-----------------L.P....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSSFVVPPCRGRRELVSVVDSGS...GFTVTRLSAYQMT......N..............LVP.G.TKYYISYLV.TK.GASTESSR...EV..PMS-------..---....---.-...-...---------------------------------................
A0A0D9S3P7_CHLSB/6-184               .......................................................................................PIQTLPLILILLAVLSPG.T....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLTVRR..A..NDSKV...VKSSFVVPPCRGRRELVSVVHSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.KK.GTATESSR...EI..PMSTLPRSNM..ESI....GLG.M...A...HTGGMVVITVLLSVTMFLLVLGFIIALALGAHK................
A0A1S3WC28_ERIEU/3-157               ....................................................................................pll----LPLILILLAVLAPG.T...aA.DFNIS....SV...P...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VRSSFVVPPCRGRRDLVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYIV.MK.GASTESSR...EI..PMSTLPRKKK..G--....---.-...-...---------------------------------glhwtgngpdrrhggy
E2RQ03_CANLF/11-177                  ..................................................................................pelpl-----------------G.P....P.DFNIS....SV...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKV...VKSSFVVPSCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.RK.GSSTESSR...EI..PMSTLPRRQA..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGLIIALALGARK................
A0A498NNM2_LABRO/314-394             .......................................................................tqiftvpsctaslpgl------------------.-....-.-----....--...-...-------------------------.------..-..-----...------------------------...----------LLQ......N..............LKN.G.TTYIMEYKI.E-.GTNQTSAN...LT..A-TTTNALAY..EQI....DSG.L...E..rRSGAMVVITVILSLAML----------------td..............
A0A401SEI5_CHIPU/143-225             ...........................................................................aplkanatyrfk------------------.-....-.-----....--...-...-------------------------.------..-..-----...------------------------...-------------......-..............---.-.--YAVRNKS.TN.VIETETNW...SE..PISLL--RVF..EPT....GLN.A...SpggRTGGMVVITTILSILLFLLLCAFAIILTY----kfwg............
A0A3B1JTZ7_ASTMX/2-170               .........................................................................lsmlfilggfipli------------------.Y....A.DFSAT....VL...TmddGVITGRFSDSVLLSLPPCDQYAGKSvDLEYLN..VntNQTTT...LNSIFTVANCS------SGINTVG...STAISRNIGYQLK......N..............LSN.G.TQYRIHYQI.GS.N---KSAP...T-..-MAT--TRSV..PDF....GND.LslpA...RSGAMVVITVILSLAMFFLLICLILS-------tvmss...........
A0A2U4BWH9_TURTR/6-85                .......................................................................................PVRTLSLILILLAVLAPRaA....A.DFNIS....SL...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSKG...L-----------------------...-------------......-..............---.-.---------.--.--------...--..----------..---....---.-...-...---------------------------------lptprhtlvprds...
A0A384C1D2_URSMA/113-246             .....................................................................lllgasgntpltsppisc------------------.-....-.-----....--...-...-------------------------.------..-..---PV...VKFSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......D..............LVP.G.TKYYISYLV.TK.GTSTESSR...EI..PMSTLPRRKV..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGARK................
G1KZK6_AILME/6-184                   .......................................................................................PVRTLPLILILLTVLALG.A....A.DFNIS....SI...S...GLLSPALTESLLVALPPCHLTGGNA.TLMVRR..A..NDSQA...VKFSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......D..............LIP.G.TKYYISYLV.TK.GTSTESSR...EI..PMSTLPRRKV..ESI....ELG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGARK................
A0A452GGC5_9SAUR/160-230             .................................................rfkyllvdlvagvvkdqtlwsdpmktlkqtstidtwpg------------------.-....-.-----....--...-...-------------------------.------..-..-----...------------------------...-------------......-..............---.-.---------.--.--------...--..----------..---....---.-...R...RSGGMIVITSILSTLIFLLVVGFLASI------fffts...........
A0A2D0QCX5_ICTPU/2-170               ........................................................................lvvllimggllplih------------------.A....D.DFPLS....ML...SvedRVITGRFINSLLLSLPPCTYAGQSV.DLEYLNcyT..NKSYT...LHNIFTV------RNYKSIGDLTG...PTAFSRNIGYQLM......N..............LTN.G.TQYRISYKI.GM.YRSTPLMA...T-..---TRTVSSY..TEI....EVG.F..pG...RSAAMVVITVILSVAAFILLIGISI--------stlvs...........
H2NFI6_PONAB/6-184                   .......................................................................................PIRTLPLILILLAVLSPG.T....A.DFNIS....SL...S...GLLSPALTERLLVALPPCHLTGGNA.TLIVRR..A..NDSKV...VTSSFVVPPCRGRRELVSVVDSGA...GFTVTRLSAYQVT......N..............LVP.G.TKYYISYLV.KK.GTATESSR...EI..PMSTLPRRTM..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVLGFIIALALGSHK................
A0A1L8GW18_XENLA/10-221              lvslqrghalrfsdlnqsnfqfftntddvlgavlsqsfmvnvpscinavgyvpstlkvavanrnptcmvdtdsikslktdptapvyy------------------.-....-.-----....--...-...-------------------------.------..-..-----...-TGQMKVPQCRLRRDLEPVKMNSMrdlGYQVGTENCTEVSgpfcnqF..............LQP.G.TSYWVNFII.LD.ETDTPRAYtgwSE..PRTTRQVRCL..DAV....DLG.L...S..gHSGGMVIITVLLSVSVFLLLLGFMAV-------vvvsra..........
#=GC seq_cons                        .................................................................................................l.h.hu.u.s....A.DFNIS....Sl...S...GLLSPALoESLLVALPPCHLTGGNA.TLhVRR..A..NDSpV...VpuuFsVPPCRGRRELVSVVDSGu...GFTVTRLuAYQVT......N..............LsP.G.TKYYISYhV.pK.GsuTESSp...El..PMSTLPR+ph..ESI....GLG.M...A...RTGGMVVITVLLSVAMFLLVlGhIluLALGspK................
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