GenomeNet

Database: Pfam
Entry: VasL
LinkDB: VasL
Original site: VasL 
#=GF ID   VasL
#=GF AC   PF12486.9
#=GF DE   Type VI secretion system, EvfB, or VasL
#=GF PI   DUF3702;
#=GF AU   Gavin OL;
#=GF SE   Prosite
#=GF GA   27.30 27.30;
#=GF TC   28.70 35.60;
#=GF NC   26.30 27.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   16826484
#=GF RT   Identification and characterization of Escherichia coli
#=GF RT   RS218-derived islands in  the pathogenesis of E. coli
#=GF RT   meningitis.
#=GF RA   Xie Y, Kolisnychenko V, Paul-Satyaseela M, Elliott S,
#=GF RA   Parthasarathy G, Yao Y, Plunkett G 3rd, Blattner FR, Kim KS;
#=GF RL   J Infect Dis. 2006;194:358-364.
#=GF RN   [2]
#=GF RM   22184413
#=GF RT   Hcp family proteins secreted via the type VI secretion system
#=GF RT   coordinately regulate Escherichia coli K1 interaction with human
#=GF RT   brain microvascular endothelial cells.
#=GF RA   Zhou Y, Tao J, Yu H, Ni J, Zeng L, Teng Q, Kim KS, Zhao GP, Guo
#=GF RA   X, Yao Y;
#=GF RL   Infect Immun. 2012;80:1243-1251.
#=GF DR   INTERPRO; IPR021069;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   EvfB or VasL is a domain found on many Gram-negative proteins
#=GF CC   with an ImpA_N domain at the N-terminus. These proteins are
#=GF CC   expressed from the pathogenicity locus that forms the bacterial
#=GF CC   type VI secretion system. The exact function of VasL is not
#=GF CC   known. One E.coli member is annotated as being EvfB, though the
#=GF CC   E.coli equivalent of ImpA would be expected to be EvfG. It is
#=GF CC   possible that in many bacteria what is a single protein in one
#=GF CC   species, eg E.coli, is a fusion of two genes in others, which
#=GF CC   would explain an ImpA at the N-terminus and a VasL at the
#=GF CC   C-terminus.
#=GF SQ   116
#=GS B6VLC8_PHOAA/309-455      AC B6VLC8.1
#=GS A0A0H5LZB1_YERIN/293-437  AC A0A0H5LZB1.1
#=GS D3VFA3_XENNA/291-437      AC D3VFA3.1
#=GS A0A0H5M0P2_YERIN/313-460  AC A0A0H5M0P2.1
#=GS A0A084A531_9GAMM/296-442  AC A0A084A531.1
#=GS A0A0U5L5U0_9GAMM/299-443  AC A0A0U5L5U0.1
#=GS W0LAX3_9GAMM/291-437      AC W0LAX3.1
#=GS A0A2D0KKX1_9GAMM/304-450  AC A0A2D0KKX1.1
#=GS A0KJC9_AERHH/324-470      AC A0KJC9.1
#=GS A0A1H3WJY1_9GAMM/299-445  AC A0A1H3WJY1.1
#=GS A0A0H3GRI9_KLEPH/303-447  AC A0A0H3GRI9.1
#=GS I3DDE7_9PAST/1-75         AC I3DDE7.1
#=GS A0A0G3CLS1_9GAMM/306-448  AC A0A0G3CLS1.1
#=GS I2B705_SHIBC/314-458      AC I2B705.1
#=GS A0A2X4TI68_SALER/288-431  AC A0A2X4TI68.1
#=GS A0A090VWU3_ESCVU/241-340  AC A0A090VWU3.1
#=GS A0A443IEX9_9GAMM/297-440  AC A0A443IEX9.1
#=GS A0A085GBD0_9GAMM/298-445  AC A0A085GBD0.1
#=GS A0A2V1H1Z9_9GAMM/300-366  AC A0A2V1H1Z9.1
#=GS W1ISR5_9GAMM/1-93         AC W1ISR5.1
#=GS A0A3R8Z4X8_9GAMM/251-376  AC A0A3R8Z4X8.1
#=GS A0A1B7K3I3_9GAMM/309-455  AC A0A1B7K3I3.1
#=GS Q7MZS6_PHOLL/309-455      AC Q7MZS6.1
#=GS K8WVF1_9GAMM/287-433      AC K8WVF1.1
#=GS A0A240BSU2_SERFI/314-458  AC A0A240BSU2.1
#=GS A0A068QX89_9GAMM/1-43     AC A0A068QX89.1
#=GS A0A0Q4NK83_9GAMM/306-447  AC A0A0Q4NK83.1
#=GS A0A1C4FGE2_9ENTR/313-457  AC A0A1C4FGE2.1
#=GS A0A0J5KX77_PLUGE/1-78     AC A0A0J5KX77.1
#=GS A0A0H2W2K9_YERPE/302-449  AC A0A0H2W2K9.1
#=GS A0A2X4THZ1_SALER/313-457  AC A0A2X4THZ1.1
#=GS A0A0A7S407_FRIPE/295-437  AC A0A0A7S407.1
#=GS A0A1I0FSU5_9GAMM/1-48     AC A0A1I0FSU5.1
#=GS A6TAQ2_KLEP7/303-447      AC A6TAQ2.1
#=GS A0A068QYM4_9GAMM/289-435  AC A0A068QYM4.1
#=GS A0A097QZE2_HAFAL/290-433  AC A0A097QZE2.1
#=GS A0A0J9BBC6_9GAMM/301-442  AC A0A0J9BBC6.1
#=GS A0A2V1HBP4_9GAMM/296-442  AC A0A2V1HBP4.1
#=GS A0A370QHB9_9ENTR/301-447  AC A0A370QHB9.1
#=GS A0A140NNL1_PROSM/284-430  AC A0A140NNL1.1
#=GS A0A1U6IPV0_9ENTR/245-351  AC A0A1U6IPV0.1
#=GS A0A2I0FQB4_9GAMM/242-369  AC A0A2I0FQB4.1
#=GS A0A2P8VKC6_9ENTR/299-444  AC A0A2P8VKC6.1
#=GS R8AU66_PLESH/318-464      AC R8AU66.1
#=GS U2LZ23_SERFO/309-455      AC U2LZ23.1
#=GS A0A0M2K8G8_9GAMM/253-381  AC A0A0M2K8G8.1
#=GS A0A097R172_HAFAL/303-449  AC A0A097R172.1
#=GS A0A0Q4MGY6_9GAMM/277-380  AC A0A0Q4MGY6.1
#=GS U3U0S2_9ENTR/1-122        AC U3U0S2.1
#=GS A0A084A4T9_9GAMM/35-184   AC A0A084A4T9.1
#=GS A0A0T9LTI6_9GAMM/288-434  AC A0A0T9LTI6.1
#=GS Q6D1L5_PECAS/326-472      AC Q6D1L5.1
#=GS A0A0H3JBT0_ECO57/292-435  AC A0A0H3JBT0.1
#=GS G7LR82_9GAMM/325-471      AC G7LR82.1
#=GS E0SGP2_DICD3/324-471      AC E0SGP2.1
#=GS S3IUU6_9ENTR/304-450      AC S3IUU6.1
#=GS D4GFH7_PANAM/314-458      AC D4GFH7.1
#=GS H2J1Z8_RAHAC/302-443      AC H2J1Z8.1
#=GS A0A084ZP41_9ENTR/288-433  AC A0A084ZP41.1
#=GS A0A2P8VK83_9ENTR/322-468  AC A0A2P8VK83.1
#=GS A0A318W0T5_9ENTR/308-454  AC A0A318W0T5.1
#=GS A0A014PUH3_9GAMM/262-384  AC A0A014PUH3.1
#=GS W1DE60_KLEPN/3-52         AC W1DE60.1
#=GS D8MM70_ERWBE/313-457      AC D8MM70.1
#=GS A0A2N5EJ98_9GAMM/260-401  AC A0A2N5EJ98.1
#=GS A0A380U3U7_9PAST/283-391  AC A0A380U3U7.1
#=GS B4ET47_PROMH/284-430      AC B4ET47.1
#=GS A0A0A2VYW3_BEABA/314-458  AC A0A0A2VYW3.1
#=GS A0A2C6CYG8_9GAMM/301-447  AC A0A2C6CYG8.1
#=GS A0A2D0KNJ1_9GAMM/292-438  AC A0A2D0KNJ1.1
#=GS B6VM74_PHOAA/285-431      AC B6VM74.1
#=GS A0A378BEC3_KLEPO/49-193   AC A0A378BEC3.1
#=GS A0A2V1HB20_9GAMM/73-219   AC A0A2V1HB20.1
#=GS A0A085JHR4_9GAMM/230-367  AC A0A085JHR4.1
#=GS A0A3N1IUL0_9ENTR/322-468  AC A0A3N1IUL0.1
#=GS A0A014PTP3_9GAMM/308-452  AC A0A014PTP3.1
#=GS A9MNT3_SALAR/313-457      AC A9MNT3.1
#=GS W1JA45_9GAMM/290-436      AC W1JA45.1
#=GS A0A3N1I3J8_9ENTR/295-441  AC A0A3N1I3J8.1
#=GS A0A2V1H631_9GAMM/207-273  AC A0A2V1H631.1
#=GS Q74PG2_YERPE/24-170       AC Q74PG2.1
#=GS A0A1T4JKU7_ENTAG/288-428  AC A0A1T4JKU7.1
#=GS A0A1I0FQJ7_9GAMM/1-108    AC A0A1I0FQJ7.1
#=GS A0A0J8VSI2_9ENTR/295-441  AC A0A0J8VSI2.1
#=GS A0A2H9U7F5_9GAMM/326-472  AC A0A2H9U7F5.1
#=GS A0A2M8S2N8_9PAST/272-404  AC A0A2M8S2N8.1
#=GS A0A2X2GGD9_RAOPL/315-459  AC A0A2X2GGD9.1
#=GS A0A378EG98_KLEPR/38-182   AC A0A378EG98.1
#=GS W1DGF5_KLEPN/1-38         AC W1DGF5.1
#=GS W1J249_9GAMM/312-458      AC W1J249.1
#=GS A0A0V9JWH5_9ENTR/299-452  AC A0A0V9JWH5.1
#=GS A0A2G0QFH5_9GAMM/292-438  AC A0A2G0QFH5.1
#=GS H5UZ69_ATLHE/268-409      AC H5UZ69.1
#=GS W1EEH0_KLEPN/3-52         AC W1EEH0.1
#=GS A0A0N0IAM1_9GAMM/305-451  AC A0A0N0IAM1.1
#=GS A0A1T4PCT5_ENTAG/314-458  AC A0A1T4PCT5.1
#=GS W1EGH7_KLEPN/1-38         AC W1EGH7.1
#=GS D1P5G4_9GAMM/298-444      AC D1P5G4.1
#=GS A0A411WLP4_9GAMM/304-446  AC A0A411WLP4.1
#=GS A0A085GIU5_9ENTR/28-173   AC A0A085GIU5.1
#=GS A0A495ANM6_9ENTR/314-458  AC A0A495ANM6.1
#=GS A0A085APM4_9ENTR/1-124    AC A0A085APM4.1
#=GS W1GYK0_KLEPN/1-60         AC W1GYK0.1
#=GS L0M6L8_ENTBF/285-428      AC L0M6L8.1
#=GS T0PFE4_PHOTE/280-412      AC T0PFE4.1
#=GS A0A250B571_9ENTR/294-439  AC A0A250B571.1
#=GS A0A084A3E1_9GAMM/6-89     AC A0A084A3E1.1
#=GS A0A068QXN9_9GAMM/288-434  AC A0A068QXN9.1
#=GS A0A2C6C5R8_9GAMM/314-460  AC A0A2C6C5R8.1
#=GS A0A0W7U744_9GAMM/318-464  AC A0A0W7U744.1
#=GS D3UYQ0_XENBS/289-435      AC D3UYQ0.1
#=GS A0A2X5B9E2_SERRU/297-438  AC A0A2X5B9E2.1
#=GS A0A318VVX5_9ENTR/285-430  AC A0A318VVX5.1
#=GS A0A1H4F4G8_9GAMM/319-465  AC A0A1H4F4G8.1
#=GS H2J179_RAHAC/303-450      AC H2J179.1
#=GS A4WCZ1_ENT38/310-454      AC A4WCZ1.1
B6VLC8_PHOAA/309-455                 ............................................s-RKQLTNLDALPPLWRLSHGSQLLQQLRTLWPASQTVQDMEKQWLQQREATALPM.SELENY..HLAQSRLQQLTARLDALDEKRGRyLTGSELKSMVFGIRQPLS.S.T.PPLEELLRQLAE...QQKNG-....AV..SPALRQQINTRFSQLLNRYYLLQ......
A0A0H5LZB1_YERIN/293-437             ............................................a-EQQLNWLSALPPQFPWEQGEQISRQLNKVYPD----NPASQLWQRRMQEKTGDA.LPLGRW..LKLNADIDHLEQRLLNSEKNRNQfMTVSELKTAVYQLRRDLY.SgG.LPAEALLGKLEQ...HATAGE....AI..SPALVKQIEQSLSALIARYVSL-l.....
D3VFA3_XENNA/291-437                 .............................................YAQQLERLAETGPLATWEAARTLTDTAEQLWPSAPAQRQATRQWEQAMTARIDSA.PLKGSW..NTTRDQLQQLADKILLQERTRGS.FTLSYLKTAIYDIQRSHG.S.D.VPLEEQLRQLSV...YAAKGD....SA..PPVLLKGIDDRFNALLGRYDRLR......
A0A0H5M0P2_YERIN/313-460             ...........................................tv--SQLDQLAVLPPLWAQTRGDAVLAQAQQVWPASHEVKQLSTLWQQQRESGAAPL.AELKHY..ALAQERLRQLAERLNGLDEKKGRyMTVSELKSVVFAIQQPLT.Q.A.LPLEELLHQYQV...QSDAGK....TP..PSVLRQQIDSRFTQLLNRYALL-s.....
A0A084A531_9GAMM/296-442             ...........................................nt--TQLNWLMALPPAWALQYGQQLIAQSQTLWPSNPEAEQMQKAWQQQLEANALPL.AALDNW..HQGMVKLQQLTDRLNALDERKGKyMTGSELKTMVFAITQEFG.K.T.VPMEEQLRQLAT...-ASTDN....SL..SGNVQSQAELRLAQLLNRYMLI-k.....
A0A0U5L5U0_9GAMM/299-443             .............................................TRQQLMRLHQLPPHWTINHSRQLLEQAQVLWPQ--QADALAVEWQQQRNAMALPI.ESLEGW..HQGMTTLQTLSDRLSQLDERKGKyITVSELKSVVFSAIQSFN.H.S.IPAEEQLRVLSH...-YPTEQ....PL..PAAARAQLEMHLKQLIAGYALLT......
W0LAX3_9GAMM/291-437                 .............................................YSEQLGTLENLSPLAGLRTAELSVAMARQLWPSNPNQVAESQRWERLLQARMGNN.AAGSGY..FQLQRRLQALSEKLLEQEQVRGS.LTISYLKTAVYQMQTELN.R.E.IPLEELLRQLSV...ARESHQ....PV..SPVLLKQIDERWNALLSRYHQLT......
A0A2D0KKX1_9GAMM/304-450             ............................................t-KRQLKMLESLSPVWQQDYGFSLVHQSKILWPQSPLSAELSAQWNKQVTMNAASI.DSLGHW..HSGMDQLAELTRRLNWLDEKRGRyITGSELKSIVFSLTQTFN.K.N.PPLEEKLRQLEE...-TAIKE....EL..SPALIQQTDMHFIQLLNRYALI-k.....
A0KJC9_AERHH/324-470                 .............................................YQNQLTRLEQTSPLYWYRYGEGLRNSLQMLYPDSLAVKALDKQWQAQLGGLQGDV.ISVPTY..LDARAGVDALLDQLLELERQRKT.VTISYLKSQLYEVQKNLM.Q.N.IPFSLRLGELEA...RKASQE....PI..TAAELKSLENDLKALNIRLYQLQ......
A0A1H3WJY1_9GAMM/299-445             .............................................TQQQLEQLAAMPPDWPLAHGTALVRQVRVLWPDTEVADAVSRQWQQQLVASATPP.DSLGGW..QQGMAQLQRLTDRLNQLDGQRGKyMTVSELKSQVFTITQAFN.Q.T.VPVEEQLRQMAQ...-QPTDQ....PA..PAALRSQTALHLKQLLARYALL-g.....
A0A0H3GRI9_KLEPH/303-447             .............................................TQRQLGELARLAPDWAVSYGDQLVHQALIRWPD--QAQPLAQQWRQQLSAGALPA.ENLTGW..SEGMQQLQRLADQLNALDEQKGKyLTVSELKTAVFAITQSFN.R.A.VPLEEQLRQLAA...-LPVDQ....PW..PAARGSLAELHLQQLIVEYALLK......
I3DDE7_9PAST/1-75                    ............................................m-------------------------------------------------------.------..-------ENLQNELLFAEKNKQG.LTISYLKTALYNMEKELD.K.I.DSLEKNLSDLSE...NKD---....--..DLLLRQKIEQQFLSLLAYYNKL-i.....
A0A0G3CLS1_9GAMM/306-448             .............................................YQQQLTSLANQSPLASHFYADNLSTLITQLWPDSKKAAALKQEWQQHQNSLRSEN.PLSDGY..SQAQKRITGLIRQINQAEAQGRT.LSLAQLKSSLNAIQRQLN.D.S.PPVEELLRQQAD...----QP....SP..TAAQTKQIEQRLNGLLSHYHEL-i.....
I2B705_SHIBC/314-458                 ............................................t-GQQLAWLDKLPPDWRLARSQQLVDQAQILWPE--QAKPLIQKWQQQLNAATLPP.EYLNGW..HQGMTTLQQLSDKLNRLDVQKGKyITVSELKSSVFSMMTAFG.Q.S.IPLEEQLRQMNQ...-LPIDS....PQ..RQRLSRDIEQHLRSQIYTL----gqmk..
A0A2X4TI68_SALER/288-431             .............................................YGRNLHQLLDASSMQPLETGMQMVRTADSRWPESLQQQQATALWHETLKERAQRS.PQLKGW..QQTRQDLRAFADLIMQ--REKEG.LTLSYIKNVIWQAERTLN.E.E.TPLESLLTQYQT...ARSQGQ....-N..TQAQEKEINERLNDVLSRWLLI-k.....
A0A090VWU3_ESCVU/241-340             .......................................ralsrt-----------------------------------------------------PD.ASLTGW..HQGMLTLQNLSERLNALDGQKGKyLTVSELKSQVFAATLAFN.K.T.VPVEEQLRLMSE...-QQTPE....TI..PEAQKRQARQHLQQLITDYFAL-t.....
A0A443IEX9_9GAMM/297-440             ............................................v-KRQLKWLTTLPPDWPQQYGFHLLSQATILWPDNPVVRQMQQGWQRQTEANALPL.TVLNSW..HEGMAKLQQLTDRLNALDEKRGKyMTVSELKSEVFAITQAFN.Q.A.PPAEELLRQYAA...DPHD--....--..--IQQKQAVMALEQLHKRYFL--lqqe..
A0A085GBD0_9GAMM/298-445             .............................................TQQQSEQLASLSPRWALDSGTHLVAQAQALWPADPATIALSQDWSRQLNANAAPL.DSLNGW..HSASAQLQQLADKLNGLDEQRGKyMTVSQLKSSVFSIQQALN.A.A.PPVEESLRKLAA...ARQQND....QI..SQQLVKQLDNQFVQLLSRYVLL-a.....
A0A2V1H1Z9_9GAMM/300-366             ............................................t-TAQLDGLLALPPGWSQQYGQQLIAQSQTLWPGNPAVTEMHKAWQQQLEANALPL.AALDNW..HQGM-------------------.------------------.-.-.------------...------....--..-----------------------vk....
W1ISR5_9GAMM/1-93                    ............................................m-------------------------------------------------------.PLKGSW..HTTRDQLQQLADKILLQERSRGS.FTLSYLKTAIYDIQRSHG.S.E.VPLEELLRQLST...HAAKGE....NA..PPVLLKTIDDRFNALLGRYDRLR......
A0A3R8Z4X8_9GAMM/251-376             .......................................pepdka--------------------QRIAQLARQVTPE---LGGQDKNWQEAVMLAALPR.EQLVLW..HTARLRLKKMLALAKVPEEQRAGcLTYAELEAQLVALRQPLE.A.M.QPAEELLRQLES...-----N....PL..SPVLRGKIENRLKQLLARYAL--il....
A0A1B7K3I3_9GAMM/309-455             .........................................idgy----LGELESLSPIWSQEYAFDMVSFLKKQFNNNSDINKLNEQWQQNIQVNALPE.DRLNQW..SEGMAKLNALSLRLDSLDGKPRSyMTGSELKTIIFNARENFN.R.S.IPLEEELRQLEA...-LQKKG....TV..AESEYQRIDTHFKQLLNRYTL--il....
Q7MZS6_PHOLL/309-455                 ............................................s-RAQLTNLTTLPAFWPLSYGSQLLQQLRTLWPASQAVQDMQNQWLHQREAAALPM.QSLENY..HLAQLRLQHLTERLDALDEKRGRyLTGSELKSMVFGIRQPLA.N.T.PPLEELLRQLAE...QKKSG-....TV..SLALLMQINTRFNQLLNRYYLL-l.....
K8WVF1_9GAMM/287-433                 .............................................YADNLNLLEKQSPIFNLKLSDSLVDKAKKLWPNNADQTYASRNWHNLITTRLENT.PINDSW..SETASLLQQLSDKIVMQERNRGS.FTLSYLKTSIYDIQKQHN.K.N.IPIEEKLREFSV...QIDNGQ....PI..SPTLINNIDAQIHGLLARYYDLQ......
A0A240BSU2_SERFI/314-458             .............................................TQRQLARLSQLPPDWALDYGNQLIEQARMLWPE--QAKPLAQQWLRQLNAASIPT.ENLNGW..HQGMTKLQQLSDRLSGLDEQKGKyMTVSELKSVVFSTMQSFN.Q.S.IPAEEQLRALSE...-NPAGE....PL..PAAAKAQLEMHLKQLIARYARL-v.....
A0A068QX89_9GAMM/1-43                .............................................-------------------------------------------------------.------..-----------------------.------------------.-.-.MPLEELLRQLGV...HAANGE....AA..PPVLLKGIDDRFNALLGRYDRLR......
A0A0Q4NK83_9GAMM/306-447             .............................................TEQQLARLTALPPDGALEFAQRLIRQARALNPGDAAVNTIATEWQQQLKAAALPE.EALDGW..QQGMAQLQQLTAKLNALDGQRGKyMTVSELKSVVYNATQAFN.R.S.VPAEEQLRLFSL...------....SP..SDFQRRQVELALEQLQKRYFLLK......
A0A1C4FGE2_9ENTR/313-457             .............................................TQQQLARLDKLPPDWNIAYSKKLTEQVQSLWPE--QAKPLVQQWQQQINVSVLPV.DTMNGW..HEGMTQLQALADKLNALDGQKGKyITVSELKSQIFGMLTSFR.Q.T.VPVEEQLRQLKL...-LPEGS....PL..RQQQIQQAEQHLRAQISTLAQ--ek....
A0A0J5KX77_PLUGE/1-78                ............................................d-------------------------------------------------------.------..---------LTRRLNALDERKGKyLTGSELKSMVFAITQDFE.R.S.VPVEARLYQLSR...-TSAGE....PL..PAAQVAQTDLYLNQLLNRYALI-r.....
A0A0H2W2K9_YERPE/302-449             ...........................................sa--MQLDQLTQLPPLWAQARGDALLSQAQQLWPTNQEVKRLNALWQQQRAAGAAPL.VELKHY..ALAQDRLRQLAERLNSLDEKKRGyMTVSELKSAVFAIQQPLA.Q.A.VPLEELLRQYQE...QLESGQ....TP..SSALRQQIDSRFSQLLNRYALL-v.....
A0A2X4THZ1_SALER/313-457             .............................................TQQQLAWLDKLPPDWNITYARKLTEQVQSLWPE--QAKPLVQQWQQQINISVLPV.DTMNGW..HEGMTQLRALADKLNALDGQRGKyITVSELKSQVFGMLTSFR.Q.T.VPVEEQLRQLKL...-LPEDS....LQ..RQQQVQQAEQRLRAQISTLAQ--ek....
A0A0A7S407_FRIPE/295-437             ............................................f-QQQLQQLYTLSPLATRYYGDNLVYITQNLWPKNKISQDMAQDWQKWLDIQRQDR.FMRDGY..YKAKRQLQKLEDTLTKAEEQNQT.LTISQVRSAIYDIKTQLD.R.E.VPLEELLRQLSV...----TK....NA..SPILIKNIDDRFNTLLSHYHELR......
A0A1I0FSU5_9GAMM/1-48                ............................................m-----------------------------------------QTWKTEREENAVSL.SELNGY..YHAQLQLQDLANKLNELDTKKGKyLT----------------.-.-.------------...------....--..-----------------------g.....
A6TAQ2_KLEP7/303-447                 .............................................TQRQLGELARLAPDWAVSYGDQLVHQALIRWPD--QAQPLAQQWRQQLSAGALPA.ENLTGW..SEGMQQLQRLADQLNALDEQKGKyLTVSELKTAVFAITQSFN.R.A.VPLEEQLRQLAA...-LPVDQ....PW..PAARGSLAELHLQQLIVEYALLK......
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A0A2N5EJ98_9GAMM/260-401             ............................................s-EQALVELGRQSPLWLQYYGFALAAQA---LPS--ETGALNAQWQQHIAANALPL.EALSGW..HQGMAGLRALTARLDALDERKGKyLTGSELKSMVFAITQHFA.R.A.VPVEEQLYNLAQ...-TPPGD....PL..PAIQASQTDMHLHQLLNRYMLLK......
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A0A0N0IAM1_9GAMM/305-451             ...........................................id--NYLSELDAISPIWAQQYGLETINYLSTQFSESPEIRLFNDKWQQNMQINAVSE.KQLTQW..NQGMEQLNNLSIRLDNLDGKPRSyITGSELKTIIFNARQHFN.Q.G.LPLEEELRRLEA...-LQLNG....IV..PESEYLRIDNHFKQLLNRYALI-k.....
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A0A085GIU5_9ENTR/28-173              ............................................y-PQNLNRLLYASPLQTLETGEQLTKTANSIWLNSEQQQKATASWNNALKLRAANS.PQLRGY..LQVQQDLHQFSALLVEREKNKEG.LTLSYLKTVAYQAETQLN.K.E.IPLEALLTQLED...DRKQN-....QN..TQTLEKQINERIDALSSRYFSI-r.....
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A0A085APM4_9ENTR/1-124               ............................................m------------------------EQTRHLYPDSELSEKISARWQSKLIANSLPD.TSLTGW..HKGFTELQKLQDRLNQLDEQKGKyLTVSELKTTVFSISKAFN.D.G.VPAEELIRQLRT...-TSQNQ....PL..SQDLLNRTALKLRQLNNSYMM--vt....
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L0M6L8_ENTBF/285-428                 .............................................YERRLQQLFDTSPIQPLETGMQMIRVADSRWPESLQQQQATAQWNETLKTRAQSS.PQLRGW..LQTRQDLHAFADLVMQ--REKEG.LTLSYIKNVIWQAERGLG.Q.E.TPLESLLTQYQD...TRAQGQ....N-..TDTLEKQINERMDGVLSRWLLL-k.....
T0PFE4_PHOTE/280-412                 .............................................YEQQLTRLADTSPLVVLQHAEQLTGLAQKTWPQDREQQRETARWQQLQAVRLDNA.PLPGSW..HQTRNQLQQLADKILEQERNRGS.FTLSYLKTAIYQIQTRHN.R.D.VPLEELLRQFSA...AVEQGH....PV..SPTLRK-----------------kdr...
A0A250B571_9ENTR/294-439             ............................................a-QRQLELLPTLSPAWLWDYGSGLVHQAQRLWPNQPETAALTRQWQQQLAVAAALP.ASLDGW..HQGMAQLQQLAHRLNGLDEKKGKyMTVSELKSQVFSITQALN.R.T.VPAEEQLRQLAA...-QPANS....PE..SAALRAQTELHLKQLMAGF----tlq...
A0A084A3E1_9GAMM/6-89                ..........................................plp-------------------------------------------------------.------..-----ELQQLTDSLNALDERKGKyMTGSELKTMVFAITQEFG.K.T.VPMEEQQRQLAA...-ASADN....RL..SANAQPQAELRLVQRLKRYILI-t.....
A0A068QXN9_9GAMM/288-434             .............................................YARQLERLAETPPLVTWEAARALTAVAEQHWPDSPVQRQATRAWEQAMTARIDSV.PLKGGW..HTTHDRLTQLADKILLQERTRGS.FTLSYLKTAVYDIQRSHG.S.E.VPLEELLRQLGV...HAANGE....AA..PPVLLKGIDDRFNALLGRYDRLR......
A0A2C6C5R8_9GAMM/314-460             .............................................YQKQLDTLKQLSPLAPYYYGNHLVATSQKIWPDSDKQKPLEQAWREWLQPSSFPL.SGINGY..HDTERGLNALLGELDEAQRQNKF.ITITRLRTVVKNIKAVMA.Q.S.EPLEERLRKLEA...QSKDGR....HI..TLAEQKAFDAYFNEVLKRYYLL-s.....
A0A0W7U744_9GAMM/318-464             .............................................YQRQLERVEQASPLALIRYGDGLRDSLQLLYPDSLAVKAMDRQWQESLQRYLGQS.AQGEAY..LYAQDGVADLLDRLQELERQRKT.VTISYLKGALYEIQKNLT.A.G.EPFSQRLDALER...RKAASD....PL..SPAEIKGMEDELKGLGIRLYNLQ......
D3UYQ0_XENBS/289-435                 .............................................YQGQLDRLAETPLLATWDAARTLTGTAAQQWPDSAEQKNATHQWTQAMTARIDSI.PLKGSW..HTTRDQLQQLADKILLQERTRGS.FTLSYLKTAVYDLQRSHG.S.E.VPLEELLRQLNG...RVVNGE....PV..PPVLLKGIDDRFNALLGRYDRLR......
A0A2X5B9E2_SERRU/297-438             .............................................TRQQLQWLMALPPDWPLRYGQQLIEQAQALWPDNPEVAEMQQAWRQHLEANALPA.TSLLGW..RDGMQKLQQLTSRLNGLDEKHGKyMTVSELKSSVFAITQAFN.R.Q.PPAEERLRRYSA...GR----....--..SEVQRKQAAMALEQLQTRY----flqq..
A0A318VVX5_9ENTR/285-430             .............................................YPEQLSVLEDLSPLAALQTADRVVAKASSLWLKDPLQIAQTQRWQQLQKARADNA.E-EDSY..FQLRLQLKALSDKLVEQEKAHGS.LTISYLKTAVYQMQNELN.R.A.TPLEELLRQMAV...SVEANQ....PP..SPLLINQTDERWNALLSRYHQL-l.....
A0A1H4F4G8_9GAMM/319-465             .............................................YQAQLDQVKHASPLAVYQYGEDLKNSLQMLYPDSLAVKEMGRQWQESLSLRQDVP.TSSPAY..LEAQARVDGMLRQLQELEQQRKT.VSISYLKSQFYEIQKSLL.S.G.TPFTQRLKQLET...QKAERG....SV..NPGELERMENELDALSIRLFKLK......
H2J179_RAHAC/303-450                 .............................................MQQQTRQLATLSPRWAQDTGSHLVSQALILWPDNPATAALAKSWTQQLNANAVPL.ENLSGW..QQANTQLQQLADKLNGLDEQRGKyMTVSQLKSSVFAIQQALN.G.S.PPVEESLRKLAQ...DKQQNK....DV..SPQLMMQLDNQFTQLLNRYVLLT......
A4WCZ1_ENT38/310-454                 .............................................TQQQIARLDKLPPDWNIARSRQLVDQAQVLWPE--QAKLLAQQWQQQLNAAALPT.EHLDGW..HLGMTKLQQLSDRLNGLDEQKGKyMTVSELKSVVFSAMQSFN.Q.S.MPAEERLRVLSQ...-IPAGQ....PL..PSAAKAQAEMHLKQLIARYAL--va....
#=GC seq_cons                        ..............................................ttQLttLtphsP.hshphuppLhppspthWPp..t.pthsppWppphpspshsh.sthsuW..ppuhppLppLsc+LstL-cp+Gp.hTlSpLKoslaslppshs.p.s.lPlEE.LRpLst....httsp....sh..ssshhpph-p+lptLlsRYhhl.......
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