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Database: Pfam
Entry: Vif
LinkDB: Vif
Original site: Vif 
#=GF ID   Vif
#=GF AC   PF00559.18
#=GF DE   Retroviral Vif (Viral infectivity) protein
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Swiss-Prot
#=GF GA   25.00 25.00;
#=GF TC   25.10 83.00;
#=GF NC   24.90 19.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Viral_infectivity_factor
#=GF RN   [1]
#=GF RM   7769728
#=GF RT   Aberrant Gag protein composition of a human immunodeficiency
#=GF RT   virus type 1 vif mutant produced in primary lymphocytes. 
#=GF RA   Simm M, Shahabuddin M, Chao W, Allan JS, Volsky DJ; 
#=GF RL   J Virol 1995;69:4582-4586.
#=GF DR   INTERPRO; IPR000475;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Human immunodeficiency virus type 1 (HIV-1) Vif is required for 
#=GF CC   productive infection of T lymphocytes and macrophages. Virions 
#=GF CC   produced in the absence of Vif have abnormal core morphology and
#=GF CC    those produced in primary T cells carry immature core proteins 
#=GF CC   and low levels of mature capsid.
#=GF SQ   25
#=GS Q87109_SIVSA/1-194    AC Q87109.1
#=GS Q8AII8_SIV/1-182      AC Q8AII8.1
#=GS VIF_HV1ET/1-192       AC Q75003.1
#=GS VIF_HV2BE/4-195       AC P18097.1
#=GS C7TQ88_9HIV1/1-192    AC C7TQ88.1
#=GS VIF_HV1EL/1-192       AC P04597.1
#=GS B3CKG9_SIV/1-183      AC B3CKG9.1
#=GS W8E994_9PLVG/1-192    AC W8E994.1
#=GS VIF_SIVSP/3-194       AC P19506.1
#=GS VIF_HV2UC/4-196       AC Q76635.1
#=GS VIF_HV2ST/3-195       AC P20878.1
#=GS VIF_SIVTN/1-198       AC Q8AII0.1
#=GS Q6R792_9HIV2/3-195    AC Q6R792.1
#=GS VIF_HV1B1/1-192       AC P69720.1
#=GS VIF_SIVEK/1-192       AC Q1A248.1
#=GS VIF_HV1AN/1-192       AC Q77374.1
#=GS VIF_HV2SB/3-195       AC P12452.1
#=GS A0A1B4WRJ9_SIV/3-198  AC A0A1B4WRJ9.1
#=GS C7TQ70_9HIV1/1-192    AC C7TQ70.1
#=GS Q89490_SIV/3-194      AC Q89490.1
#=GS Q89490_SIV/3-194      DR PDB; 3RWJ C; 1-8;
#=GS Q89490_SIV/3-194      DR PDB; 3RWI C; 1-10;
#=GS VIF_SIVMB/1-192       AC Q1A266.1
#=GS VIF_HV1H2/1-192       AC P69723.1
#=GS A8E114_9HIV1/1-192    AC A8E114.1
#=GS VIF_HV2G1/3-195       AC P18043.1
#=GS Q77Y25_9PLVG/3-194    AC Q77Y25.1
Q87109_SIVSA/1-194               ...MEKHWIVRPLWKVTGGQQERWTSLVKYHMHVS.KQCVHWRY-----TPHTKIRWNWYSYQEWVIPLKDGALIKVTNYWHL-TPEKGWL..ETYATGIGY..SKGEWFTELDPWTADHIIHWSYFPCFTDRAVQQAIRGEKYLW..-CKH-QVGHQptgQVPSLQYLALRVYT.....NGL.RR---------------------------------vaptsrrgssqgspqesqrrdtrmarnmgfaq
Q8AII8_SIV/1-182                 ...MEKQWIVIPTWKLDRHAVERWNSLVKYHKYKGeKHLDKWDL-----KAHFQCS-GWWTHSQKYIPLEEDEQIIITILWNL-TPEKGWL..STYAMTIEY..KFTNYYTHIDPQTADRMIHWKYLPCFTEQAIRQALLGKRLT-..VCYFHWGHKG...KVGSLQYLALLSYT.....---.-----------------------------------aycnngrrgprdprrsrrggskylvgk.....
VIF_HV1ET/1-192                  ...MENRWQVLIVWQVDRMKIRTWNSLVKHHMHIS.RRANGWVYRHHYDSRHPKVS------SEVHIPL-GEARLIIKTYWGLQTGERDWH..LGHGVSIEW..RLRSYNTQVDPGLADHLIHMHYFDCFAESAIRKAILGYRVSP..RCDY-QAGHN...KVGSLQYLALTALI.....KPK.KAKPPLPSVSKLVEDKWNKPQKTRGRRGNHTMNGH................................
VIF_HV2BE/4-195                  ...DRN-WIVVPTWRVPG-RMEKWHALVKYLKYRT.KDLEEVRY-----VPHHKVGWAWWTCSRVIFPLQGKSHLEIQAYWNL-TPEKGWL..SSHAVRLTW..YTEKFWTDVTPDCADILIHSTYFSCFTAGEVRRAIRGEKLLS..CCNYPQAHKA...QVPSLQYLALVVVQ.....QND.RPQRKGTARKQWRRDHWRGLRVAREDHRSLKQGGS................................
C7TQ88_9HIV1/1-192               ...MENRWQVMIVWQVDRMRIRAWHSLVKHHMYIS.KKAQGWFYRHHYESRHPKVS------SEVHIPI-QDGRLIVRTYWGLQPGEKEWQ..LGHGVAIEW..RQRKYSTQVDPDLADQLIHLQYFDCFSESAIRKAILGQNIKH..RCEY-QTGHN...KVGSLQYLALKALV.....EPR.RVKPPLPSVRKLTEDRWNKPQRTKGHRESHSMNG-c...............................
VIF_HV1EL/1-192                  ...MENRWQVMIVWQVDRMRIKTWKSLVKHHMYVS.KKANRWFYRHHYESPHPKIS------SEVHIPL-GEARLVIKTYWGLHTGEREWH..LGQGVSIEW..RKRRYSTQVDPGLADQLIHMYYFDCFSESAIRKAILGDIVSP..RCEY-QAGHN...KVGSLQYLALTALI.....APK.QIKPPLPSVRKLTEDRWNKPQQTRGHRGSHTMNGH................................
B3CKG9_SIV/1-183                 ...MEKEWIAVPLIKISKGRFRRWSYWIAELI-QE.KQAR-----FLFGSWHVHAE--CFTRHIVRIPLQGHWEMQIRCYWNL-APEIGWIdtLGFNIRMVW..E-NKWETFITVKLADVLIHSQHFECWTQSAVKNTIRQGYLHPidSCKYH-QGHL...GVLTLQALCLQALQ.....HEQ.LRKRKAPNRR-------------------------tpgntrgssryarav.................
W8E994_9PLVG/1-192               ...MENRWQVMIVWQVDRMRIRTWNSLVKHHMYVS.RKAKKWVYRHHYESQHPKVS------SEVHIPL-GDAKIVIRTYWGLQTGERDWH..LGHGVSIEW..RQRKYSTQIDPELADRLIHLHYFDCFSDSAIRKAILGQVVRS..RCDYP-SGHN...KVGSLQYLALKALT.....TQK.RIKPPLPSVKKLTEDRWNKPQKIRGHREDSTMSGH................................
VIF_SIVSP/3-194                  .ee-KN-WIVVPTWRIPG-RLEKWHSLIKHLKYNT.KDLQKACY-----VPHHKVGWAWWTCSRVIFPLKDEAHLEVQGYWNL-TPEKGWL..STYAVRITW..YSRNFWTDVTPDYADTLLHGTYFPCFSEGEVRRAIRGEKLLS..CCKFPKAHKN...QVPSLQYLALTVVS.....-HV.RSQGENPTWKQWRRNNRRGLRLARQNSRRNKQGS-s...............................
VIF_HV2UC/4-196                  ..e-KN-WIVVPTWRIPG-RLEKWHSLVKYLKHRT.KELQQVSY-----VPHHKVGWAWWTCSRVIFPLKEEAYLEVQGYWNL-TPERGFL..SSYAVRLTW..YKRSFYTDVTPDVADQLLHGSYFSCFTANEVRRAIRGEKILS..YCNYPSAHEG...QVPSLQFLALRVIQ.....EGKdGSQGESATRKQRRRNNRRSIRLARKNNNRAQQG--ss..............................
VIF_HV2ST/3-195                  .eg--KRWIAVPTWRVPG-RMERWHSLIKYLKYRT.GDLEKVCY-----VPHHKVGWAWWTCSRVIFPLKGESHLEIQAYWNL-TPEKGWL..SSYSVRLTW..YTEKFWTDVTPDCADSLIHSTYFSCFTAGEVRRAIRGEKLLS..CCNYPQAHKY...QVPSLQFLALVVVQ.....QNG.RPQRDNTTRKQWRRNYRRGLRVARQDGRSHKQRGS................................
VIF_SIVTN/1-198                  ...MENRWQVQVVWMIDRMRLRTWTSLVKHHIFTT.KCCKDWKYRHHYETDTPKRA------GEIHIPLTERSKLVVLHYWGLACGERPWH..LGHGIGLEW..RQGKYSTQIDPETADQLIHTRYFTCFAAGAVRQAILGERILT..FCHF-QSGHR...QVGTLQFLAFRKVVesqdkQPK.GPRRPLPSVTKLTEDRWNKHRTTTGRRENHTLSG-c...............................
Q6R792_9HIV2/3-195               .eg-KN-WIVVPTWRVPG-RMEKWHSLVKYLKYRT.KDLEDVCY-----VPHHKVGWAWWTCSRVIFPLKGNSHLEIQAYWNL-TPEKGWL..SSYSVRMTW..YTERFWTDVTPDCADSLIHSTYFSCFTAGEVRRAIRGEKLLS..CCNYPQAHRA...QVPSLQFLALVVVQ.....QND.RPQRNGTPRKQWRRDYRRGLQLARQDGRSHKQRGS................................
VIF_HV1B1/1-192                  ...MENRWQVMIVWQVDRMRIRTWKSLVKHHMYVS.GKARGWFYRHHYESPHPRIS------SEVHIPL-GDARLVITTYWGLHTGERDWH..LGQGVSIEW..RKKRYSTQVDPELADQLIHLYYFDCFSDSAIRKALLGHIVSP..RCEY-QAGHN...KVGSLQYLALAALI.....TPK.KIKPPLPSVTKLTEDRWNKPQKTKGHRGSHTMNGH................................
VIF_SIVEK/1-192                  ...MENRWQVMVVWQVDRMRVRTWNSLVKHHMYVS.KKARGWFYRHHYETDNPKIS------SEIHIPL-GEAKLVIVTYWGLMPGERPWH..LGHGVSIEW..RQGIYRTQIDPELADKLIHLYYFDCFTASAIRQAVLGRPVIP..KCEY-PAGHK...QVGSLQYLALIAWV.....GVQ.KRRPPLPSVTKLTEDRWNRHQKIKDHRGSHTTNG-l...............................
VIF_HV1AN/1-192                  ...MENRWQVLIVWQVDRQKVKAWNSLVKYHKYRS.RKTENWWYRHHYESRNPRVS------SSVYIPV-GVAHVVVTTYWGLMPGERDEH..LGHGVSIEW..RYKKYKTQIDPETADRMIHLHYFTCFTASAVRKAILGQRVLT..KCEYP-TGHS...QVGTLQLLALRAVV.....KAR.SRKPPLPSVQKLTEDRWNKHLRIRDQLKSPSMNGH................................
VIF_HV2SB/3-195                  .qg--KRWIAVPTWRVPG-RMEKWHSLIKYLKYRT.KDLEQVRY-----VPHHKVGWAWWTCSRVIFPLKGNSHLEIQAYWNL-TPEKGWL..SSYSVRMTW..YSEGFWTDVTPDCADTLIHSTYFSCFTAGEVRRAIRGEKSLS..CCNYPQAHKS...KVPSLQFLALVVVQ.....QND.KPQRDNTTRKQWRRNYRRGLRLARQDGRSHKQRGS................................
A0A1B4WRJ9_SIV/3-198             .re--KEWVMRITWRVDSEHISRWQGIVRYWMEK-.-RGIQWEY-----KMHYKIHWAWYTMCQYIIPL-ETGDIYVDMFWHL-TPQTGWL..STYAVGIQYlsYQGNYRTELDPGTADSMIHLHYFNCFTERAIQKAIRGERFV-..FCNYPEGHKQt.gQVQTLQFLALQAVQ.....DGF.RRKRKQGKEARVARN--------------------lgfkqrtlgrvakryahrsqpr..........
C7TQ70_9HIV1/1-192               ...MENRWQVMIVWQVDRMRIRTWHSLVKYHMYVS.RKAKGWFYRHHYESRHPKVS------SEVHIPI-EEARLIIRTYWGLQTEEKDWQ..LGHGVSVEW..SQGRYRTQIDPDLADQLIHLQYFDCFSESAIRKAILGQIIYH..KCEY-QAGHK...QVGSLQYLALRALV.....APK.RRKPPLPSVKKLTEDRWNKPQKTKGHRENHTMNG-c...............................
Q89490_SIV/3-194                 ..e-EKRWIAVPTWRIPE-RLERWHSLIKYLKYKT.KDLQKVCY-----VPHFKVGWAWWTCSRVIFPLQEGSHLEVQGYWHL-TPEKGWL..STYAVRITW..YSKNFWTDVTPNYADILLHSTYFPCFTAGEVRRAIRGEQLLS..CCRFPRAHKY...QVPSLQYLALKVVS.....-DV.RSQGENPTWKQWRRDNRRGLRMAKQNSRGDKQRG-g...............................
#=GR Q89490_SIV/3-194      SS    ..X-XXXXXXXXXXXXXX-XXXXXXXXXXXXXXXX.XXXXXXXX-----XXXXXXXXXXXXXXXXXXXXXX--S--S----XX-XXXXXXX..XXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXX...XXXXXXXXXXXXXX.....-XX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-X...............................
VIF_SIVMB/1-192                  ...MENRWQVMIVWQVDRMRIKTWNSLVKHHMYVS.RKARNWFYRHHYESNNPKIS------SEVHIPL-GEAKLVITTYWGLTTGERAWH..LGHGVSIEW..RQRSYRTQIDPDLADQLIHLYYFDCFAESAIRKAILGQIVSP..RCEYP-TGHN...KVGSLQYLALSTLI.....KSK.PRRPPLPSVRKLAEDRWNNSQKTRDHKGNHIMNGH................................
VIF_HV1H2/1-192                  ...MENRWQVMIVWQVDRMRIRTWKSLVKHHMYVS.GKARGWFYRHHYESPHPRIS------SEVHIPL-GDARLVITTYWGLHTGERDWH..LGQGVSIEW..RKKRYSTQVDPELADQLIHLYYFDCFSDSAIRKALLGHIVSP..RCEY-QAGHN...KVGSLQYLALAALI.....TPK.KIKPPLPSVTKLTEDRWNKPQKTKGHRGSHTMNGH................................
A8E114_9HIV1/1-192               ...MENRWQVMIVWQVDRMRINTWKSLVKYHMYIS.KKTRRWAYRHHYDSNHPRIS------SEVHIPL-GDAELVVTTYWGLHTGERKWH..LGQGVSIEW..RLKRYRTQVDPGLADQLIHMHYFDCFSESAIRNAILGHRVIP..RCEY-QAGHS...QVGTLQFLALAALV.....NPK.KTKPPLPSVKKLVEDRWNQPQKTKGHRENQPMNGH................................
VIF_HV2G1/3-195                  egk--N-WI-VPTWRVPGRRMERWHSLVKYLKYRT.RDLEEVRY-----VPHHKVGWAWWTCSRVIFPLKGESHLEIQAYWNL-TPEKGWL..SSHSVRITW..YTERFWTDVTPDYADILIHSTYFSCFTAGEVRRAIRGEKLLS..CCNYPQAHKV...QVPSLQYLALVVVQ.....QND.RPQRKGTARKQWRRDHWRGLRVARQDYRSLKQRGS................................
Q77Y25_9PLVG/3-194               ..e-EKRWIAVPTWRIPE-RLERWHSLIKYLKYKT.KDLQKVCY-----VPHFKVGWAWWTCSRVIFPLQEGSHLEVQGYWHL-TPEKGWL..STYAVRITW..YSKNFWTDVTPNYADILLHSTYFPCFTAGEVRRAIRGEQLLS..CCRFPRAHKY...QVPSLQYLALKVVS.....-DV.RSQGENPTWKQWRRDNRRGLRMAKQNSRGDKQRG-g...............................
#=GC SS_cons                     ..X-XXXXXXXXXXXXXX-XXXXXXXXXXXXXXXX.XXXXXXXX-----XXXXXXXXXXXXXXXXXXXXXX--S--S----XX-XXXXXXX..XXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXX...XXXXXXXXXXXXXX.....-XX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-X...............................
#=GC seq_cons                    ...MENRW.Vh.sWpVschRlcpW+SLVKaahYho.KcscpWhY.....ssH.Klu......ScVhIPL.G-u+LhIpsYWsL.TsE+sWh...uauVsIpW..ppccahTpVDP-hADpLIHhpYFsCFosuAlR+AIhGcplls..pCcY.pAt+s...QVsSLQYLALpsl......psc.+.psshPoh+phpcDphpt.phs+tcppspp.sG.................................
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