#=GF ID   Vpu
#=GF AC   PF00558.20
#=GF DE   Vpu protein
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Swiss-Prot
#=GF GA   24.00 24.00;
#=GF TC   24.00 24.30;
#=GF NC   23.90 23.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Vpu
#=GF RN   [1]
#=GF RM   9338017
#=GF RT   Enhancement of retroviral production from packaging cell lines
#=GF RT   expressing the human immunodeficiency type 1 VPU gene. 
#=GF RA   Kobinger GP, Mouland AJ, Lalonde JP, Forget J, Cohen EA; 
#=GF RL   Gene Ther 1997;4:868-874.
#=GF RN   [2]
#=GF RM   7853484
#=GF RT   The human immunodeficiency virus type 1 Vpu protein specifically
#=GF RT   binds to the cytoplasmic domain of CD4: implications for the
#=GF RT   mechanism of degradation. 
#=GF RA   Bour S, Schubert U, Strebel K; 
#=GF RL   J Virol 1995;69:1510-1520.
#=GF RN   [3]
#=GF RM   9182993
#=GF RT   Secondary structure and tertiary fold of the human
#=GF RT   immunodeficiency virus protein U (Vpu) cytoplasmic domain in
#=GF RT   solution. 
#=GF RA   Willbold D, Hoffmann S, Rosch P; 
#=GF RL   Eur J Biochem 1997;245:581-588.
#=GF DR   INTERPRO; IPR008187;
#=GF DR   SCOP; 1vpu; fa;
#=GF DR   TC; 1.A.40;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The Vpu protein contains an N-terminal transmembrane spanning
#=GF CC   region and a C-terminal cytoplasmic region. The HIV-1 Vpu
#=GF CC   protein stimulates virus production by enhancing  the release of
#=GF CC   viral particles from infected cells. The VPU protein binds
#=GF CC   specifically to CD4.
#=GF SQ   16
#=GS VPU_SIVEK/1-76            AC Q1A244.1
#=GS Q9YX50_9HIV1/1-78         AC Q9YX50.1
#=GS C7TQ72_9HIV1/1-79         AC C7TQ72.1
#=GS C7TQ90_9HIV1/1-78         AC C7TQ90.1
#=GS A0A1I7FJF7_9CLOT/5-86     AC A0A1I7FJF7.1
#=GS VPU_HV1ET/1-84            AC Q75007.1
#=GS VPU_HV1B1/1-81            AC P69699.1
#=GS VPU_HV1B1/1-81            DR PDB; 2JPX A; 5-27;
#=GS VPU_HV1B1/1-81            DR PDB; 2N28 A; 1-81;
#=GS VPU_SIVMB/1-80            AC Q1A262.1
#=GS K1QEQ8_CRAGI/25-101       AC K1QEQ8.1
#=GS VPU_HV1H2/1-81            AC P05919.1
#=GS VPU_HV1H2/1-81            DR PDB; 2N29 A; 1-54;
#=GS W8EB84_9PLVG/4-84         AC W8EB84.1
#=GS VPU_HV1AN/1-85            AC Q77376.1
#=GS A0A430A1H8_9ENTE/1-79     AC A0A430A1H8.1
#=GS Q77Y20_9PLVG/1-81         AC Q77Y20.1
#=GS A0A1S3HY80_LINUN/236-299  AC A0A1S3HY80.1
#=GS VPU_HV1EL/1-80            AC P05925.1
VPU_SIVEK/1-76                       ...........MLLLIKLG.FIGLAIETLIVIVVWAI..VYRIYREVKVE....EKISQLRQRIRDRAE..DSGNESDGDAEE-LANLL------------ppdridqd...
Q9YX50_9HIV1/1-78                    ...........MLFWEIWA.IVGLVVALIIVIVVWTL..VFIEYKKLRRQ....RRIDSLYNRIRERAE..DSGNESDGDAEE-LSTLVG-MGNFDPW---vg.........
C7TQ72_9HIV1/1-79                    ...........MSPLEISA.ITGLVVALIIAIVVWSI..VIIEYRKILKQ....RKIDRLLDRIRDRAE..DSGNESDGDAEE-LSALVE-MGDHNPW---gyn........
C7TQ90_9HIV1/1-78                    ...........MPPLDIAA.IVGLIVALILAIIVWSI..VLIEYRKILKQ....KKIDRLLDRIRDRAE..DSGNESDGDTEE-LSALVE-MGNHNPW---gy.........
A0A1I7FJF7_9CLOT/5-86                ......fgatc-----IVG.IICMIVFMFIGIWLFIV..ALKAYNQFKYKnyilEKINQNLSKLSKNND..DSIDDFDFEYDEMLNK--------------kgdlassledi
VPU_HV1ET/1-84                       mvdllakvdyr------IV.IVAFIVALIIAIVVWTI..AYIEYRKLLRQ....RRIDRLIKRTRERAE..DSGNESDGDTEE-LSTMVD-MGNLRLLD--vn.........
VPU_HV1B1/1-81                       .........mq--PI-QIA.IVALVVAIIIAIVVWSI..VIIEYRKILRQ....RKIDRLIDRLIERAE..DSGNESEGEISA-LVEMGVEMGHHAPWD--vddl.......
#=GR VPU_HV1B1/1-81            SS    .........--------SH.CHHHHHHHHHHHHHHHH..HHHS-SS---H....HHHHTHHHHHHHH-S..S--S---SHHHH-HHHHHHHHSS--SS---S---.......
VPU_SIVMB/1-80                       .......mdiv----QQVGlLVVLIIELVIVIVIWVK..VYKLCKEDRRQ....KKIDRLIARIRERAE..DSGNESDGDTEE-LQDLIT--EGDNLM---higi.......
K1QEQ8_CRAGI/25-101                  .......ntav-----IVG.VVAAVVLAI-LVVVFII..VFKRTRTTKPK....DEMQGSEKRIQEREE..NAH-LRNGSENTGLTNIYENKE--------tddkpvl....
VPU_HV1H2/1-81                       .......qpip-----IVA.IVALVVAIIIAIVVWSI..VIIEYRKILRQ....RKIDRLIDRLIERAE..DSGNESEGEISA-LVEMGVEMGHHAPWD--vddl.......
#=GR VPU_HV1H2/1-81            SS    .......XXXX-----XXX.XXXXXXXXXXXXXXXXX..XXX-TTSS-SS....GGGGGHHHHHHHHHH..TTSS--HHHHHH-HHHHHHHTT-TTTTS--SS--.......
W8EB84_9PLVG/4-84                    .....lqlsai----QIGA.IVGLIVALILAIVVWTI..VAIEVKKILKQ....RKIDKLVDRIRQRAE..DSGNESEGDTDE-LAKLVE-MGGFDPW---vad........
VPU_HV1AN/1-85                       ...........MHHRDLLA.IIIISALLFINVILWGF..ILRKYLEQKEQdrkeREILERLRRIREIRD..DSDYESNGEEEQEVMDLVLSHGFDNPMFE-p..........
A0A430A1H8_9ENTE/1-79                .......mtpq-------I.MITFVVLLIIIYIIWKI..YTIFTENKKIN....DNINQLKQRNKERRElfSPINEVDGLELDTINQLFHFKGQFEL----fef........
Q77Y20_9PLVG/1-81                    .........mq--PI-QIA.IVALVVAIIIAIVVWSI..VIIEYRKILRQ....RKIDRLIDRLIERAE..DSGNESEGEISA-LVEMGVEMGHHAPWD--vddl.......
A0A1S3HY80_LINUN/236-299             .....vvavti------TL.AVAVVVLLVVIVVVWRRaaRIKETLQEKLQ....QEISQLQEQIANIEP..AT-HNSDGDS--------------------si.........
VPU_HV1EL/1-80                       ...........MQPLGIIA.IAALVVAIILAIVVWTI..VFIEYRRIKKQ....RRIDCLLDRITERAE..DSGNESEGDREK-LSKLVE-MGHHAPWD--idd........
#=GC SS_cons                         .......XXXX-----XSH.CHHHHHHHHHHHHHHHH..HHHSTTSS-SC....HHHHCHHHHHHHHHC..TTSS--HCHHHH-HHHHHHHCTSTTTTS--SS--.......
#=GC seq_cons                        ................hlu.IVuLlVtlIIsIVVWsI..VhIEY+clh+Q....++IDpLlcRIpERAE..DSGNES-G-t-c.Lspls..hGths.h...sss........
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