GenomeNet

Database: Pfam
Entry: hNIFK_binding
LinkDB: hNIFK_binding
Original site: hNIFK_binding 
#=GF ID   hNIFK_binding
#=GF AC   PF12196.9
#=GF DE   FHA Ki67 binding domain of hNIFK
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Gavin OL;
#=GF SE   pdb_2aff
#=GF GA   25.00 25.00;
#=GF TC   27.80 27.00;
#=GF NC   22.20 21.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   MKI67IP
#=GF RN   [1]
#=GF RM   16244663
#=GF RT   Sequential phosphorylation and multisite interactions
#=GF RT   characterize specific target recognition by the FHA domain of
#=GF RT   Ki67.
#=GF RA   Byeon IJ, Li H, Song H, Gronenborn AM, Tsai MD;
#=GF RL   Nat Struct Mol Biol. 2005;12:987-993.
#=GF DR   INTERPRO; IPR021043;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain family is found in eukaryotes, and is approximately
#=GF CC   40 amino acids in length. The family is found in association
#=GF CC   with Pfam:PF00076. There are two conserved sequence motifs:
#=GF CC   TPVCTP and LERRKS. This domain is found on the human nucleolar
#=GF CC   protein hNIFK. It binds to the fork-head-associated domain of
#=GF CC   human Ki67. High-affinity binding requires sequential
#=GF CC   phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238,
#=GF CC   pThr234 and pSer230. This interaction is involved in cell cycle
#=GF CC   regulation.
#=GF SQ   187
#=GS A0A401P516_SCYTO/202-238  AC A0A401P516.1
#=GS A0A2R9A149_PANPA/172-211  AC A0A2R9A149.1
#=GS A0A2K5E9E1_AOTNA/211-238  AC A0A2K5E9E1.1
#=GS A0A3Q3LGE4_9TELE/208-244  AC A0A3Q3LGE4.1
#=GS A0A1S3AL27_ERIEU/242-281  AC A0A1S3AL27.1
#=GS H7BZL0_HUMAN/36-75        AC H7BZL0.1
#=GS A0A218VBF7_9PASE/220-257  AC A0A218VBF7.1
#=GS A0A091E432_FUKDA/237-275  AC A0A091E432.1
#=GS A0A3B5BIQ8_9TELE/192-228  AC A0A3B5BIQ8.1
#=GS A0A1D5R5K8_MACMU/210-249  AC A0A1D5R5K8.1
#=GS A0A2I3RBH0_PANTR/185-224  AC A0A2I3RBH0.1
#=GS F1NT45_CHICK/210-247      AC F1NT45.2
#=GS A0A093G9B4_DRYPU/129-166  AC A0A093G9B4.1
#=GS G3N9P4_GASAC/227-263      AC G3N9P4.1
#=GS M7AHE7_CHEMY/114-145      AC M7AHE7.1
#=GS A0A087QTW9_APTFO/139-176  AC A0A087QTW9.1
#=GS A0A2K5UUR2_MACFA/215-254  AC A0A2K5UUR2.1
#=GS A0A2K6LFI2_RHIBE/227-266  AC A0A2K6LFI2.1
#=GS I3MSC9_ICTTR/232-270      AC I3MSC9.2
#=GS A0A2Y9G2S3_TRIMA/195-234  AC A0A2Y9G2S3.1
#=GS A0A3B3CG88_ORYME/191-226  AC A0A3B3CG88.1
#=GS A0A1L8EV96_XENLA/62-101   AC A0A1L8EV96.1
#=GS A0A2I4CNE9_9TELE/209-245  AC A0A2I4CNE9.1
#=GS A0A2Y9RZZ4_PHYMC/228-267  AC A0A2Y9RZZ4.1
#=GS A0A091FPH6_9AVES/143-180  AC A0A091FPH6.1
#=GS G1ST34_RABIT/229-268      AC G1ST34.1
#=GS G3N9P2_GASAC/100-136      AC G3N9P2.1
#=GS A0A2K6CMG7_MACNE/227-266  AC A0A2K6CMG7.1
#=GS A0A3B4TPK7_SERDU/208-244  AC A0A3B4TPK7.1
#=GS A0A1S3WTD6_ERIEU/240-279  AC A0A1S3WTD6.1
#=GS A0A2I3M8U8_PAPAN/170-209  AC A0A2I3M8U8.1
#=GS G1NH99_MELGA/230-267      AC G1NH99.2
#=GS A0A3Q4HDG9_NEOBR/208-244  AC A0A3Q4HDG9.1
#=GS A0A3P8XQZ9_ESOLU/207-244  AC A0A3P8XQZ9.1
#=GS H0Z1Z6_TAEGU/143-180      AC H0Z1Z6.1
#=GS G5AS30_HETGA/163-201      AC G5AS30.1
#=GS U3KFL7_FICAL/208-245      AC U3KFL7.1
#=GS A0A2I3GEL4_NOMLE/194-233  AC A0A2I3GEL4.1
#=GS A0A2R9AVC8_PANPA/199-238  AC A0A2R9AVC8.1
#=GS L9JRU4_TUPCH/188-227      AC L9JRU4.1
#=GS A0A091UP79_NIPNI/134-171  AC A0A091UP79.1
#=GS A0A1U7UKR4_TARSY/228-267  AC A0A1U7UKR4.1
#=GS A0A452S716_URSAM/231-270  AC A0A452S716.1
#=GS L9L012_TUPCH/128-159      AC L9L012.1
#=GS G3RQP7_GORGO/227-266      AC G3RQP7.1
#=GS A0A1S3FI33_DIPOR/215-252  AC A0A1S3FI33.1
#=GS E2RHG8_CANLF/234-272      AC E2RHG8.2
#=GS H0VA71_CAVPO/232-270      AC H0VA71.1
#=GS M3XPP4_MUSPF/234-273      AC M3XPP4.1
#=GS A0A2K6USJ0_SAIBB/232-271  AC A0A2K6USJ0.1
#=GS A0A1L8ENK8_XENLA/201-242  AC A0A1L8ENK8.1
#=GS A0A4D9ENY9_9SAUR/207-242  AC A0A4D9ENY9.1
#=GS G7NB31_MACMU/227-266      AC G7NB31.1
#=GS A0A383Z359_BALAS/235-274  AC A0A383Z359.1
#=GS A0A226NE41_CALSU/215-252  AC A0A226NE41.1
#=GS G1QKG8_NOMLE/227-266      AC G1QKG8.1
#=GS A0A3Q3A9W1_KRYMA/203-239  AC A0A3Q3A9W1.1
#=GS A0A099ZIV1_TINGU/130-167  AC A0A099ZIV1.1
#=GS A0A0D9RVW7_CHLSB/227-266  AC A0A0D9RVW7.1
#=GS A0A1U7QLV3_MESAU/254-292  AC A0A1U7QLV3.1
#=GS A0A3Q0H084_ALLSI/211-248  AC A0A3Q0H084.1
#=GS A0A3B4WK45_SERLL/209-245  AC A0A3B4WK45.1
#=GS H2QIN2_PANTR/227-266      AC H2QIN2.1
#=GS A0A1V4K644_PATFA/217-254  AC A0A1V4K644.1
#=GS A0A3P8N6B4_ASTCA/208-244  AC A0A3P8N6B4.1
#=GS G5AWW6_HETGA/162-200      AC G5AWW6.1
#=GS A0A493T5F0_ANAPP/225-260  AC A0A493T5F0.1
#=GS A0A3B4GF06_9CICH/208-244  AC A0A3B4GF06.1
#=GS A0A3Q1H3M4_9TELE/208-244  AC A0A3Q1H3M4.1
#=GS A0A3P9C560_9CICH/208-244  AC A0A3P9C560.1
#=GS A0A2K6CMI0_MACNE/216-255  AC A0A2K6CMI0.1
#=GS W5U6P2_ICTPU/198-235      AC W5U6P2.1
#=GS A0A0D9RXC7_CHLSB/218-257  AC A0A0D9RXC7.1
#=GS A0A2K5KUB5_CERAT/227-266  AC A0A2K5KUB5.1
#=GS MK67I_MOUSE/250-288       AC Q91VE6.1
#=GS A0A3Q3XAH9_MOLML/178-215  AC A0A3Q3XAH9.1
#=GS A0A3B3UGK1_9TELE/205-242  AC A0A3B3UGK1.1
#=GS A0A2K5J9K4_COLAP/227-266  AC A0A2K5J9K4.1
#=GS G5BKC7_HETGA/237-275      AC G5BKC7.1
#=GS A0A2K5KUC2_CERAT/215-254  AC A0A2K5KUC2.1
#=GS A0A091I578_CALAN/144-181  AC A0A091I578.1
#=GS A0A226PNF8_COLVI/215-252  AC A0A226PNF8.1
#=GS A0A2U3ZK04_ODORO/233-272  AC A0A2U3ZK04.1
#=GS K7FEZ0_PELSI/102-137      AC K7FEZ0.1
#=GS G3WEC9_SARHA/256-295      AC G3WEC9.1
#=GS A0A2Y9PH87_DELLE/229-268  AC A0A2Y9PH87.1
#=GS A0A2I3SSA8_PANTR/204-243  AC A0A2I3SSA8.1
#=GS W5M2A4_LEPOC/207-244      AC W5M2A4.1
#=GS A0A3B5BCN1_9TELE/171-207  AC A0A3B5BCN1.1
#=GS A0A2U3W928_ODORO/231-270  AC A0A2U3W928.1
#=GS A0A3Q0SM20_AMPCI/209-244  AC A0A3Q0SM20.1
#=GS A0A452E456_CAPHI/240-279  AC A0A452E456.1
#=GS MK67I_RAT/206-242         AC Q5RJM0.1
#=GS A0A087X3X3_POEFO/206-243  AC A0A087X3X3.1
#=GS G1KD10_ANOCA/215-250      AC G1KD10.2
#=GS R0JZP1_ANAPL/138-175      AC R0JZP1.1
#=GS G3N9N6_GASAC/244-280      AC G3N9N6.1
#=GS A0A2K6AFT0_MANLE/107-146  AC A0A2K6AFT0.1
#=GS A0A452E467_CAPHI/230-269  AC A0A452E467.1
#=GS A0A3B4CLD2_PYGNA/205-241  AC A0A3B4CLD2.1
#=GS A0A3L8SMR1_CHLGU/220-257  AC A0A3L8SMR1.1
#=GS A0A3Q7VY80_URSAR/231-270  AC A0A3Q7VY80.1
#=GS H2PXL1_PONAB/192-231      AC H2PXL1.1
#=GS MK67I_XENTR/200-240       AC Q6GL69.1
#=GS A0A2U3XX29_LEPWE/231-270  AC A0A2U3XX29.1
#=GS A0A401SLV2_CHIPU/174-210  AC A0A401SLV2.1
#=GS A0A091FMX9_CORBR/136-173  AC A0A091FMX9.1
#=GS F7CHW8_ORNAN/209-246      AC F7CHW8.1
#=GS A0A060WVC6_ONCMY/207-244  AC A0A060WVC6.1
#=GS F6ZLL0_CALJA/227-266      AC F6ZLL0.2
#=GS F7ASK0_HORSE/224-263      AC F7ASK0.2
#=GS A0A2R9C2V1_PANPA/185-224  AC A0A2R9C2V1.1
#=GS A0A1S3FIL8_DIPOR/216-253  AC A0A1S3FIL8.1
#=GS F7FU02_MACMU/36-75        AC F7FU02.2
#=GS A0A3B1J8Q1_ASTMX/202-239  AC A0A3B1J8Q1.1
#=GS A0A2I3SZ62_PANTR/199-238  AC A0A2I3SZ62.1
#=GS G3N9N9_GASAC/208-244      AC G3N9N9.1
#=GS A0A0A0AQ16_CHAVO/143-180  AC A0A0A0AQ16.1
#=GS I3JM67_ORENI/208-244      AC I3JM67.1
#=GS H2PQ78_PONAB/225-264      AC H2PQ78.1
#=GS H0XGI4_OTOGA/174-212      AC H0XGI4.1
#=GS A0A2I3GD13_NOMLE/93-132   AC A0A2I3GD13.1
#=GS A0A3B3Q7V1_9TELE/207-244  AC A0A3B3Q7V1.1
#=GS A0A0Q3MN13_AMAAE/166-203  AC A0A0Q3MN13.1
#=GS A0A1A6GEY0_NEOLE/84-108   AC A0A1A6GEY0.1
#=GS A0A2R9A6I2_PANPA/187-226  AC A0A2R9A6I2.1
#=GS A0A402EV35_9SAUR/210-245  AC A0A402EV35.1
#=GS A0A3P8RTQ1_AMPPE/208-244  AC A0A3P8RTQ1.1
#=GS A0A2K6QS39_RHIRO/227-266  AC A0A2K6QS39.1
#=GS A0A2K6G8J1_PROCO/120-158  AC A0A2K6G8J1.1
#=GS A0A3P9NSE8_POERE/205-241  AC A0A3P9NSE8.1
#=GS G3H134_CRIGR/254-292      AC G3H134.1
#=GS A0A2I2Y6F9_GORGO/91-130   AC A0A2I2Y6F9.1
#=GS A0A3B5QW40_XIPMA/206-243  AC A0A3B5QW40.1
#=GS H2SJC6_TAKRU/208-244      AC H2SJC6.2
#=GS G5APY2_HETGA/132-170      AC G5APY2.1
#=GS G3WED0_SARHA/245-284      AC G3WED0.1
#=GS MK67I_HUMAN/227-266       AC Q9BYG3.1
#=GS MK67I_HUMAN/227-266       DR PDB; 2AFF B; 228-266;
#=GS M3WDX8_FELCA/226-265      AC M3WDX8.3
#=GS A0A2Y9S0S9_TRIMA/189-228  AC A0A2Y9S0S9.1
#=GS H3DKE3_TETNG/208-241      AC H3DKE3.1
#=GS A0A2Y9KVC4_ENHLU/234-273  AC A0A2Y9KVC4.1
#=GS MK67I_BOVIN/230-269       AC Q3SZM1.1
#=GS A0A2U3V9D8_TURTR/229-268  AC A0A2U3V9D8.1
#=GS A0A2U9C881_SCOMX/210-247  AC A0A2U9C881.1
#=GS A0A3Q2GNA2_CYPVA/247-284  AC A0A3Q2GNA2.1
#=GS A0A2I3GCX0_NOMLE/194-233  AC A0A2I3GCX0.1
#=GS A0A3B3CH06_ORYME/198-233  AC A0A3B3CH06.1
#=GS A0A091VF83_OPIHO/131-168  AC A0A091VF83.1
#=GS G1P747_MYOLU/231-269      AC G1P747.1
#=GS C9J808_HUMAN/122-161      AC C9J808.8
#=GS A0A3Q7UK52_VULVU/244-283  AC A0A3Q7UK52.1
#=GS A0A2K5DTL3_AOTNA/233-272  AC A0A2K5DTL3.1
#=GS A0A093HE61_STRCA/130-167  AC A0A093HE61.1
#=GS F6XSZ6_MONDO/246-285      AC F6XSZ6.2
#=GS A0A340X524_LIPVE/229-268  AC A0A340X524.1
#=GS A0A2Y9KVJ4_ENHLU/235-274  AC A0A2Y9KVJ4.1
#=GS A0A093SBK2_9PASS/136-173  AC A0A093SBK2.1
#=GS L5JYK5_PTEAL/232-271      AC L5JYK5.1
#=GS F7GF12_MONDO/195-220      AC F7GF12.1
#=GS W5PV04_SHEEP/230-269      AC W5PV04.1
#=GS MK67I_DANRE/204-241       AC Q8JIY8.2
#=GS G1LEM7_AILME/231-270      AC G1LEM7.1
#=GS A0A3P8WEU9_CYNSE/209-244  AC A0A3P8WEU9.1
#=GS A0A3B4AV46_9GOBI/202-239  AC A0A3B4AV46.1
#=GS G5B456_HETGA/169-207      AC G5B456.1
#=GS A0A384BQ11_URSMA/215-254  AC A0A384BQ11.1
#=GS A0A3B3WWS7_9TELE/205-242  AC A0A3B3WWS7.1
#=GS A0A091J9F9_EGRGA/134-171  AC A0A091J9F9.1
#=GS A0A3Q2UZF2_HAPBU/208-244  AC A0A3Q2UZF2.1
#=GS G3UGN5_LOXAF/250-289      AC G3UGN5.1
#=GS A0A096NAZ1_PAPAN/227-266  AC A0A096NAZ1.2
#=GS A0A3B5BDZ3_9TELE/186-222  AC A0A3B5BDZ3.1
#=GS A0A3Q3EDP8_9LABR/208-245  AC A0A3Q3EDP8.1
#=GS J9NXM6_CANLF/231-270      AC J9NXM6.1
#=GS A0A2K5UUL6_MACFA/227-266  AC A0A2K5UUL6.1
#=GS G3TVD0_LOXAF/205-244      AC G3TVD0.1
#=GS A0A3Q1HN75_ANATE/208-244  AC A0A3Q1HN75.1
#=GS A0A1A6HZ73_NEOLE/198-236  AC A0A1A6HZ73.1
#=GS A0A2R9B3P2_PANPA/227-266  AC A0A2R9B3P2.1
#=GS A0A096MEC0_POEFO/206-243  AC A0A096MEC0.1
#=GS A0A2I2YMA4_GORGO/187-226  AC A0A2I2YMA4.1
#=GS A0A2I0MG96_COLLI/150-187  AC A0A2I0MG96.1
#=GS F1RXX7_PIG/229-268        AC F1RXX7.2
#=GS A0A2K5QJS3_CEBCA/192-231  AC A0A2K5QJS3.1
#=GS A0A3Q1CEA7_AMPOC/208-244  AC A0A3Q1CEA7.1
#=GS B5X6J4_SALSA/207-244      AC B5X6J4.1
A0A401P516_SCYTO/202-238             ....TVNSQDVTPECTPTVLKRRQS.--LKML-DD.TDDEITFKV-k......
A0A2R9A149_PANPA/172-211             ....TVDTQGPTPVCTSTFLERQKS.EVAEMNDDD.EDNEIVFEKP.......
A0A2K5E9E1_AOTNA/211-238             .kkv-----GPTPVCTPTFLERRKS.EV-------.----------piscvke
A0A3Q3LGE4_9TELE/208-244             ....SSCSDDVTPICTPSVLERRKS.--MAIE-DD.ADDEIVIKRP.......
A0A1S3AL27_ERIEU/242-281             ....TVDSQSSTPVCTPTFLEKRKS.EVAEMNDDD.DDNEIVFKQP.......
H7BZL0_HUMAN/36-75                   ....TVDSQGPTPVCTPTFLERRKS.QVAELNDDD.KDDEIVFKQP.......
A0A218VBF7_9PASE/220-257             ....SLSSQGPTPVCTPAVLERRKA.--AQMDDDT.EDDEVTVRLP.......
A0A091E432_FUKDA/237-275             ...t-GDSQSTTPVCTPTFLEKRKS.EVAGMN-DD.KDDEIVFKQP.......
A0A3B5BIQ8_9TELE/192-228             ....SVSLQDTTPVCTPSLLERRKS.---MVVDDD.ADDEIVVKMP.......
A0A1D5R5K8_MACMU/210-249             ....TVDIQGLTPVCTPIFLERQKS.EVAEMNDDD.EDNEIVFKQP.......
A0A2I3RBH0_PANTR/185-224             ....TVDIQGLTPVCTPTFLERRKS.EVAEMNDDD.EANEIVFKQP.......
F1NT45_CHICK/210-247                 ....SLTSQDPTPVCTPTVLERRKA.--QQADDDP.DDNEIIIKLP.......
A0A093G9B4_DRYPU/129-166             ....SVSSQDPTPVCTPTVLERRKA.--AQVDDDA.EDNEITLRLP.......
G3N9P4_GASAC/227-263                 ....SMCSDDVTPICTPSVLERRKS.---TVVDDD.GDDEIILRMP.......
M7AHE7_CHEMY/114-145                 ...f-----DPTPVCTPTALERRKS.QPAEAD---.-EDEITIKLP.......
A0A087QTW9_APTFO/139-176             ....SLSSQDPTPVCTPAVLERRKA.--SQVDDDT.EDNEITLRLP.......
A0A2K5UUR2_MACFA/215-254             ....TVDSQGPTPVCTPTFLERRKS.EVAELNDDD.KDNEIVFKQP.......
A0A2K6LFI2_RHIBE/227-266             ....TVDSQGPTPVCTPTFLERRKS.EVAELNDDD.KDNEIVFKQP.......
I3MSC9_ICTTR/232-270                 ....SIDSQGPTPVCTPTFLEKRKS.EVVGMD-DD.EDDEIVFKLP.......
A0A2Y9G2S3_TRIMA/195-234             ....STNSQGSTPVCTPTFLEKRKS.EVAKMNDDD.EDNEITFKQP.......
A0A3B3CG88_ORYME/191-226             ....SSCSDDVTPVCTPSFTERRKS.---AVS-DD.TDDEIILKIP.......
A0A1L8EV96_XENLA/62-101              ....SVSSRDPNPVCTSTVLERRKSlRLEQID-DQ.EEDEVVLKLP.......
A0A2I4CNE9_9TELE/209-245             ....STCSEDPTPVCTPTFLERRKS.---TAANDE.DDNEIIINMP.......
A0A2Y9RZZ4_PHYMC/228-267             ....TVDSQGPTPVCTPTFLEKRKS.EVAKMNDDD.KDNEIVFKQP.......
A0A091FPH6_9AVES/143-180             ....SLSSQDPTPVCTPTVLERRKA.--SQADDDT.EDSEITLKLP.......
G1ST34_RABIT/229-268                 ....TVDSQGPTPVCTPSYLERRKS.EAAEMKDDE.KDDEIVFRQP.......
G3N9P2_GASAC/100-136                 ....SMCSDDVTPICTPSVLERRKS.---TVVDDD.GDDEIILRMP.......
A0A2K6CMG7_MACNE/227-266             ....TVDSQGPTPVCTPTFLERRKS.EVAELNDDD.KDNEIVFKQP.......
A0A3B4TPK7_SERDU/208-244             ....STCSDDITPVCTPSLLERRKS.---MVVDDD.ADDEIVIKIP.......
A0A1S3WTD6_ERIEU/240-279             ....TVDSQSSTPVCTPTFLEKRKS.EVAEMNDDD.DDNEIVFKQP.......
A0A2I3M8U8_PAPAN/170-209             ....TVDSQGPTPVFTPTFLERQKF.EVAEMNDDD.KDNEIVFKQP.......
G1NH99_MELGA/230-267                 ...c-LNSQDPTPVCTPTVLERRKA.--QQADDDT.DDNEIMIKLP.......
A0A3Q4HDG9_NEOBR/208-244             ....SSCTDDSTPVCTPSFLERRKS.---TAAEND.ADDEIIIKMP.......
A0A3P8XQZ9_ESOLU/207-244             ....STCSEDITPVCTPSVLERRKS.--MKTNDDD.SDSEIIIK--nt.....
H0Z1Z6_TAEGU/143-180                 ....SLSSQDPTPVCTPAVLERRKA.--AQMDGDT.EDDEITLKLP.......
G5AS30_HETGA/163-201                 ....TVDSQSATPACAPTLLEKRKS.EVAEMK-GD.KDDEIVFKQP.......
U3KFL7_FICAL/208-245                 ....SLSSQDPTPVCTPAVLERRKV.--ARMDDDT.EDDEVILRLP.......
A0A2I3GEL4_NOMLE/194-233             ....TVDSQGPTPVCTSTFLERRKS.EVAEMNDDD.EDNKIVFKQP.......
A0A2R9AVC8_PANPA/199-238             ....TVDSQGPTPVCTSTFLERRKS.EVAEMNDDD.EDNKIVFKQK.......
L9JRU4_TUPCH/188-227                 ....TVDSQGPTPVCTPTVLEKRKS.EVTEMNDDD.NDNEIVFKQP.......
A0A091UP79_NIPNI/134-171             ....SLSSQDPTPVCTPTVLERRKA.--AQVDDDG.EDNEITLRLP.......
A0A1U7UKR4_TARSY/228-267             ....TVDSQGPTPVCTPTFLERRKS.EVTEMSDDD.KDNEIVFKQP.......
A0A452S716_URSAM/231-270             ....TVDSQGPTPVCTPTFLEKRKS.EVAKMNVDD.KDNEIVFKQP.......
L9L012_TUPCH/128-159                 ...r-LDSQGPTPVRTPTFLEEQKS.EVAEIKDDD.K---------e......
G3RQP7_GORGO/227-266                 ....TVDSQGPTPVCTPTFLERRKS.QVAELNDDD.KDDEIVFKQP.......
A0A1S3FI33_DIPOR/215-252             ....SVDSQGPTPVCTPTFLEKRKS.EVAELS--D.KDDEILFKQP.......
E2RHG8_CANLF/234-272                 .vfi----NGSTPVCTPAFLEKRKS.EAAKINVDD.EDNEIVFKQP.......
H0VA71_CAVPO/232-270                 ....TVDSQSATPVCTPTFLEKRKS.EVAGVN-DD.KDDEIVFRQP.......
M3XPP4_MUSPF/234-273                 ....TVDSQGPTPVCTPTFLEKRKS.EVAKMNVDD.KDNEIIFKQP.......
A0A2K6USJ0_SAIBB/232-271             ....TVDSQGPTPVCTPAFLERRKS.EVAEMNDDD.EDNEIVFKQP.......
A0A1L8ENK8_XENLA/201-242             ....SVSSQDPTPVCTPTVLERRKSvRLEQIEDEEeDDDEVVLKLP.......
A0A4D9ENY9_9SAUR/207-242             ....SVNSQDRTPVCTPTALERRKS.---QSAEGD.-EDEITIKLP.......
G7NB31_MACMU/227-266                 ....TVDSQGPTPVCTPTFLERRKS.EVAELNDDD.KDNEIVFKQP.......
A0A383Z359_BALAS/235-274             ....TVDSQGPTPVCTPTFLEKRKS.EVAKMNDDD.KDNEIVFKQP.......
A0A226NE41_CALSU/215-252             ....SLTSQDPTPVCTPTVLERRKA.--QQGDDDT.DDNEITIKLP.......
G1QKG8_NOMLE/227-266                 ....TVDSQGPTPVCTPTFLERRKS.EVAELNDDD.KDDEIIFKQP.......
A0A3Q3A9W1_KRYMA/203-239             ....SSCSNDPTPVCTPSFLERRKA.---TAADDE.EDDEVIVNMP.......
A0A099ZIV1_TINGU/130-167             ....SLNSQDPTPVCTPTVLERRKA.--HEADDDT.EDNEITVKLP.......
A0A0D9RVW7_CHLSB/227-266             ....TVDSQGPTPVCTPTFLERRKS.EVAELNDDD.KDNEIVFKQP.......
A0A1U7QLV3_MESAU/254-292             ....SVDSQGPTPVCTPTFLERRKS.EVIEVN-DS.KDNEIIFKQP.......
A0A3Q0H084_ALLSI/211-248             ....SVNSQDPTPVCTPTVLSRRKS.--QSQESDL.DDSEITIKLP.......
A0A3B4WK45_SERLL/209-245             ....STCSDDITPVCTPSVLERRKS.---MVVDDD.ADDEIVIKIP.......
H2QIN2_PANTR/227-266                 ....TVDSQGPTPVCTPTFLERRKS.QVAELNDDD.KDDEIVFKQP.......
A0A1V4K644_PATFA/217-254             ....SLSSQDPTPVCTPAVLERRKA.--AQVDDDT.EDNEITLRL-a......
A0A3P8N6B4_ASTCA/208-244             ....SSCTDDSTPVCTPSFLERRKS.---TAAEND.ADDEIIIKMP.......
G5AWW6_HETGA/162-200                 ....TVDSQSATPVCTPTFLEKRKS.EVAEMN-DD.KDDEIVFKQP.......
A0A493T5F0_ANAPP/225-260             .pag-----DPTPVCTPTVLERRQA.--HQADDDA.EDKEITLKLP.......
A0A3B4GF06_9CICH/208-244             ....SSCTDDSTPVCTPSFLERRKS.---TAAEND.ADDEIIIKMP.......
A0A3Q1H3M4_9TELE/208-244             ....SACSEDATPVCTPSLLERRKS.---MVVDDD.ADDEIVVKMP.......
A0A3P9C560_9CICH/208-244             ....SSCTDDSTPVCTPSFLERRKS.---TAAEND.ADDEIIIKMP.......
A0A2K6CMI0_MACNE/216-255             ....TVDSQGPTPVCTPTFLERRKS.EVAELNDDD.KDNEIVFKQP.......
W5U6P2_ICTPU/198-235                 ....SVCSEDTTPVCTPSVLERRRS.--IKITDDD.VDDEIVLKVP.......
A0A0D9RXC7_CHLSB/218-257             ....TADTQGPTPVCTSMFLERGKS.EVAVMNNDD.EDNERVFKKP.......
A0A2K5KUB5_CERAT/227-266             ....TVDSQGPTPVCTPTFLERRKS.EVAELNDDD.KDNEIVFKQP.......
MK67I_MOUSE/250-288                  ....SVDSQGPTPVCTPTFLERRKS.QVMEVG-GD.KDDEIILKLP.......
A0A3Q3XAH9_MOLML/178-215             ..sl--PPQDATPVCTPSLLERRKS.--AVVNEDD.EDDEIVIKMP.......
A0A3B3UGK1_9TELE/205-242             ..as-SC-SDTTPVCTPSFLERRKS.--TVVLDDE.EDSEIILKMP.......
A0A2K5J9K4_COLAP/227-266             ....TVDSQGPTPVCTPTFLERRKS.EVAELNDDD.KDNEIVFKQP.......
G5BKC7_HETGA/237-275                 ....TVDSQSATAVCTPVFLEKRKS.EVAEMN-DD.KDDETAFKQP.......
A0A2K5KUC2_CERAT/215-254             ....TVDSQGPTPVCTPTFLERRKS.EVAELNDDD.KDNEIVFKQP.......
A0A091I578_CALAN/144-181             ....SLNSQDPTPVCTPTVLERRKA.--SQVDDDP.EDKEITLRLP.......
A0A226PNF8_COLVI/215-252             ....SLTSQDPTPVCTPTVLERRKA.--QQGDDDT.DDNEITIKLP.......
A0A2U3ZK04_ODORO/233-272             ....TVESQGPTPVCTPTFLEKRKS.EVAKMNADD.QDNEIVFKQP.......
K7FEZ0_PELSI/102-137                 ....SVDSQAPTPACTPTTLERRKS.QTAESD---.-EEEITIKLP.......
G3WEC9_SARHA/256-295                 ....SMDSQGPTPICSPTFLERRKA.QAAEMNDDD.EDNEIVLKLP.......
A0A2Y9PH87_DELLE/229-268             ....TVDSQGPTPVCTPTFLEKRKS.EVAKMNDDD.KDNEIVFKQP.......
A0A2I3SSA8_PANTR/204-243             ....STKGQGPTPVCTPTFLERRKS.QVAELNDDD.KDDEIVFKQP.......
W5M2A4_LEPOC/207-244                 ....TTDSLDVTPVCTPTVLEKRKS.--MKVEDSD.GDDEIIIK--at.....
A0A3B5BCN1_9TELE/171-207             ....STCSEDTTPVCTPSLLERRKS.---MVVDDD.ADDEIVVKMP.......
A0A2U3W928_ODORO/231-270             ....TVESQGPTPVCTPTFLEKRKS.EVAKMNADD.QDNEIVFKQP.......
A0A3Q0SM20_AMPCI/209-244             ....SSCTDDSTPVCTPSFLEKRKS.---TAA-DD.ADDEIIIKMP.......
A0A452E456_CAPHI/240-279             ...a-VDSQGPTPVCTPTFLEKRKS.EVAKMNDDD.KDNEIVFKHP.......
MK67I_RAT/206-242                    ....SEANQDPTPVCTPTFLERRKS.QLMEIN---.DDDEIILKLP.......
A0A087X3X3_POEFO/206-243             ....SSCSDQTTPVCTPSFLERRKS.--TVVLDDE.EDSEIILKMP.......
G1KD10_ANOCA/215-250                 ....SVNSEDPTPVCTPTFFERRKS.---QPE-DS.EDTEIILKSP.......
R0JZP1_ANAPL/138-175                 ....SLSSQDPTPVCTPTVLERRQA.--HQADDDA.EDKEITLKLP.......
G3N9N6_GASAC/244-280                 ..nl--SSIDVTPICTPSVLERRKS.---TVVDDD.GDDEIILRMP.......
A0A2K6AFT0_MANLE/107-146             ....TVDSQGPTPVCTPTFLERRKS.EVAELNDDD.KDNEIVFKQP.......
A0A452E467_CAPHI/230-269             ...a-VDSQGPTPVCTPTFLEKRKS.EVAKMNDDD.KDNEIVFKHP.......
A0A3B4CLD2_PYGNA/205-241             ....SVCSEDTTPVCTPSVLEKRRS.----MKVDD.DDDEVIIKM-qp.....
A0A3L8SMR1_CHLGU/220-257             ....SLRSQDPTPVCTPAVLERRKA.--AQVDDDT.EDNEITLKLP.......
A0A3Q7VY80_URSAR/231-270             ....TVDSQGPTPVCTPTFLEKRKS.EVAKMNVDD.KDNEIVFKQP.......
H2PXL1_PONAB/192-231                 ....TVDSQGPTPVCTPTFLERRKS.EVAELNDDD.KDDEIVFKQP.......
MK67I_XENTR/200-240                  ....SVSSQDPTPVCTPTVLERRKSvRLEQNDEDD.DDGEVVLKLP.......
A0A2U3XX29_LEPWE/231-270             ....TVDSQGPTPVCTPTFLEKRKS.EVAKMNVDD.QDKEIVFKQP.......
A0A401SLV2_CHIPU/174-210             ....TVNSQDVTPVCTPTTLKQRES.--LKTV-DD.TDDEITFKV-q......
A0A091FMX9_CORBR/136-173             ....SLSSQDPTPVCTPAVLERRKA.--AQVDDDT.EDDEITLRLP.......
F7CHW8_ORNAN/209-246                 ....TVDSQAPTPVCTPTFLERRKS.VALGMS--E.EDNEIILKLP.......
A0A060WVC6_ONCMY/207-244             ....STCSEDVTPVCTPSVLERRRS.--MKINEDD.SDGEIIIK--nt.....
F6ZLL0_CALJA/227-266                 ....TVDSQGPTPVCTPAFLERRKS.EVTGMDEDD.KDNEIVFKQP.......
F7ASK0_HORSE/224-263                 ....TADSQGPTPVCTPTFLEKRKS.EVATMKDDD.KDNEIVFKQP.......
A0A2R9C2V1_PANPA/185-224             ....TVDIQGLTPVCTPTFLERRKS.EVAEMNDDD.EANEIVFKQP.......
A0A1S3FIL8_DIPOR/216-253             ....SVDSQGPTPVCTPTFLEKRKS.EVAELS--D.KDDEILFKQP.......
F7FU02_MACMU/36-75                   ....TVDSQGPTPVCTPTFLERRKS.EVAELNDDD.KDNEIVFKQP.......
A0A3B1J8Q1_ASTMX/202-239             ....SVCSEDATPVCTPSILERRKS.--IRVEDDD.VDDEIVLK--tq.....
A0A2I3SZ62_PANTR/199-238             ....TVDSQGPTPVCTSTFLERRKS.EVAEMNDDD.EDNKIVFKQK.......
G3N9N9_GASAC/208-244                 ....SMCSDDVTPICTPSVLERRKS.---TVVDDD.GDDEIILRMP.......
A0A0A0AQ16_CHAVO/143-180             ....SLSSQDPTPVCTPTVLERRKA.--SQVDDDA.EDNEITVRLP.......
I3JM67_ORENI/208-244                 ....SSCTDDSTPVCTPSFLERRKS.---TAAEND.ADDEIIIKMP.......
H2PQ78_PONAB/225-264                 ....TVDSQGPTPVCTPTFLERRKS.EVAELNDDD.KDDEIVFKQP.......
H0XGI4_OTOGA/174-212                 ....TVDSQGPTPVCTPAFLEKRKS.EVAAMN-DD.EDNEIVFKQP.......
A0A2I3GD13_NOMLE/93-132              ....TVDIQGLTPVCTPPFLERRKS.EVAEINDHD.EANETVFKQP.......
A0A3B3Q7V1_9TELE/207-244             ....SVCSQADTPVCTPSVLEKRKS.--LKIDDDE.EDDEVIIK--at.....
A0A0Q3MN13_AMAAE/166-203             ....SLSSQDPTPVCTPTVLEHRRA.--AQMDGDA.EDNEITLKLP.......
A0A1A6GEY0_NEOLE/84-108              fwkd------------------RKS.EVVEMN-DD.KDNGIIFKQP.......
A0A2R9A6I2_PANPA/187-226             ....TVDTQGPTPVCTSTFLERQKS.EVAEMNDDD.EDNEIVFEKP.......
A0A402EV35_9SAUR/210-245             ....SESNELPTPACTPTVLERRKD.---QPE-DA.DEKEIVLRLP.......
A0A3P8RTQ1_AMPPE/208-244             ....SVCSEDSTPVCTPSLLERRKS.---MVVDDD.ADDEIVVKMP.......
A0A2K6QS39_RHIRO/227-266             ....TVDSQGPTPVCTPTFLERRKS.EVAELNDDD.KDNEIVFKQP.......
A0A2K6G8J1_PROCO/120-158             ..fp---SLGPTPVCTPTFLEKRKS.EVAEMNDDD.KDNEIVFKQP.......
A0A3P9NSE8_POERE/205-241             ..as-SC-SDTTPVCTPSFLDRRKS.---TVVLDD.EDSEIILKMP.......
G3H134_CRIGR/254-292                 ....SVDSQGPTPVCTPTFLERRKS.EVTEIN-DS.KDDEVIFKQP.......
A0A2I2Y6F9_GORGO/91-130              ....TVDTQDPTPVCTSTFLERQKS.EVAEMNDDD.EDNEIVFEKP.......
A0A3B5QW40_XIPMA/206-243             ....SSCSDQTTPVCTPSFLERRKS.--TVVLDDE.EDSEIILKMP.......
H2SJC6_TAKRU/208-244                 ....SSCSEDATPVCTPSVLEKRKS.---MVVDDN.ADDEVVVKMP.......
G5APY2_HETGA/132-170                 ....TVDSQSATPVYTPTFLEKRKS.EVAEMN-DD.KDDEIVFKQP.......
G3WED0_SARHA/245-284                 ....SMDSQGPTPICSPTFLERRKA.QAAEMNDDD.EDNEIVLKLP.......
MK67I_HUMAN/227-266                  ....TVDSQGPTPVCTPTFLERRKS.QVAELNDDD.KDDEIVFKQP.......
#=GR MK67I_HUMAN/227-266       SS    ....X--TTS------HHHHHHHHH.HHHH--GGG.GS-SEEESS-.......
M3WDX8_FELCA/226-265                 ....TVDSQGPTPVCTPTFLEKRKS.EVAKMNVDD.KDNEIVFKQP.......
A0A2Y9S0S9_TRIMA/189-228             ....STNSQGSTPVCTPTFLEKRKS.EVAKMNDDD.EDNEITFKQP.......
H3DKE3_TETNG/208-241                 ....STCSEDATPVCTPSVLERRKS.MSEEPSEEE.E---------enk....
A0A2Y9KVC4_ENHLU/234-273             ....TVDSQGPTPVCTPTFLEKRKS.EVAKMNVDD.KDNEIVFKQP.......
MK67I_BOVIN/230-269                  ...a-VDSQGPTPVCTPAFLEKRKS.EVAKMNDDD.KDNEIVFKQP.......
A0A2U3V9D8_TURTR/229-268             ....TVDSQDPTPVCTPTFLEKRKS.EVAKMNDDD.KDNEIVFKQP.......
A0A2U9C881_SCOMX/210-247             ....STCSDDTTPFCTPSLLERRKS.--MVIGDDD.VDDEIVIKIP.......
A0A3Q2GNA2_CYPVA/247-284             ....SSCSEDATPVCTPSFLERRKS.--TIVIEDD.DDEEIVINMP.......
A0A2I3GCX0_NOMLE/194-233             ....TVDSQGPTPVCTSTFLERRKS.EVAEMNDDD.EDNKIVFKQP.......
A0A3B3CH06_ORYME/198-233             ....SSERNDVTPVCTPSFTERRKS.---AVS-DD.TDDEIILKIP.......
A0A091VF83_OPIHO/131-168             ....SLSSQDPTPLCTPTVLECRKA.--SQADGDA.EDNEITLRL-a......
G1P747_MYOLU/231-269                 ....TVDSQGPTPVCTPTFLDKRKS.EVAEMN-DD.EDNEIVFKQP.......
C9J808_HUMAN/122-161                 ....TVDSQGPTPVCTPTFLERRKS.QVAELNDDD.KDDEIVFKQP.......
A0A3Q7UK52_VULVU/244-283             ....TVDSQGSTPVCTPAFLEKRKS.EAAKINVDD.EDNEIVFKQP.......
A0A2K5DTL3_AOTNA/233-272             ...n-VDSQGPTPVCTPTFLEKRKS.EVTEMNDDD.KDNEIVFKQP.......
A0A093HE61_STRCA/130-167             ....SLNSQDPTPVCTPTVLERRKA.--HEADDDT.EDNEITIRLP.......
F6XSZ6_MONDO/246-285                 ....TVDSQGATPICSPTFLERRKA.QAAEMNDDD.DDNEIIFKLP.......
A0A340X524_LIPVE/229-268             ....TVDSQDPTPVCTPTFLEKRKS.EVAKMNDDD.KDNEIVFKQP.......
A0A2Y9KVJ4_ENHLU/235-274             ....TVDSQGPTPVCTPTFLEKRKS.EVAKMNVDD.KDNEIVFKQP.......
A0A093SBK2_9PASS/136-173             ....SLTSQDPTPVCTPAVLERRKA.--AQVDDDA.EDDEVTLRLP.......
L5JYK5_PTEAL/232-271                 ....TVDSQGPTPVCTPTFLEKRKS.EAAEMNDDD.KDNEIVFKQP.......
F7GF12_MONDO/195-220                 ....TVASQGATPICSPTFLERRKA.QAVEM----.----------.......
W5PV04_SHEEP/230-269                 ...a-VDSQGPTPVCTPTFLEKRKS.EVAKMNDDD.KDNEIVFKHP.......
MK67I_DANRE/204-241                  ....SVCSEDVTPVCTPSLLERRKS.--LRVEDDD.VDDEIVIKV-k......
G1LEM7_AILME/231-270                 ....TVDSQGPTPVCTPTFLEKRKS.EVAKMNVDD.KDNEIVFKQP.......
A0A3P8WEU9_CYNSE/209-244             ....STCSEDATPVCTPSVLERRKS.---TVV-GD.GDEEIVLRIP.......
A0A3B4AV46_9GOBI/202-239             ....STVSDDTTPLCTPSLLERRKS.--MVVDDDE.EDNEIIVKMP.......
G5B456_HETGA/169-207                 ....TVDSQSATPVCTPTLLETRKS.EVAEMN-DD.KDDEIVFKQP.......
A0A384BQ11_URSMA/215-254             ....TVDSQGPTPVCTPTFLEKRKS.EVAKMNVDD.KDNEIVFKQP.......
A0A3B3WWS7_9TELE/205-242             ..as-SC-SDTTPVCTPSFLERRKS.--TVVLDDE.EDSEIILKMP.......
A0A091J9F9_EGRGA/134-171             ....SLSSQDPTPVCTPTVLERRKA.--AQGDDDA.EDNEITLRLP.......
A0A3Q2UZF2_HAPBU/208-244             ....SSCTDDSTPVCTPSFLERRKS.---TAAEND.ADDEIIIKMP.......
G3UGN5_LOXAF/250-289                 ....STNSQGSTPVCTPTFLERRKC.EVAEMNDDE.EDKEIIFKQP.......
A0A096NAZ1_PAPAN/227-266             ....TADSQGPTPVCTPTFLERRKS.EVAELNDDD.KDNEIVFKQP.......
A0A3B5BDZ3_9TELE/186-222             ....STCSEDTTPVCTPSLLERRKS.---MVVDDD.ADDEIVVKMP.......
A0A3Q3EDP8_9LABR/208-245             ....STCSTDTTPVCTPSVLERRKS.--MVVDDDD.ADDEIVIKLP.......
J9NXM6_CANLF/231-270                 ....TVDSQGSTPVCTPAFLEKRKS.EAAKINVDD.EDNEIVFKQP.......
A0A2K5UUL6_MACFA/227-266             ....TVDSQGPTPVCTPTFLERRKS.EVAELNDDD.KDNEIVFKQP.......
G3TVD0_LOXAF/205-244                 ....STNSQGSTPVCTPTFLERRKC.EVAEMNDDE.EDKEIIFKQP.......
A0A3Q1HN75_ANATE/208-244             ....SSCSDDTTPVCTPSLLERRKS.---MVVDDD.ADDEIVVKLP.......
A0A1A6HZ73_NEOLE/198-236             ....SVDSEGPTPICTPTFLERRKS.QVTEIN-DX.KDNEIIFKQP.......
A0A2R9B3P2_PANPA/227-266             ....TVDSQGPTPVCTPTFLERRKS.QVAELNDDD.KDDEIVFKQP.......
A0A096MEC0_POEFO/206-243             ....SSCSDQTTPVCTPSFLERRKS.--TVVLDDE.EDSEIILKMP.......
A0A2I2YMA4_GORGO/187-226             ....TVDTQDPTPVCTSTFLERQKS.EVAEMNDDD.EDNEIVFEKP.......
A0A2I0MG96_COLLI/150-187             ....SLSSQDPTPVCTPAVLERRKA.--AQVDDDA.EDNEITLRL-a......
F1RXX7_PIG/229-268                   ....TVDSQGPTPVCTPTFLEKRKS.EVAKMNDDD.KDHEIVFKQP.......
A0A2K5QJS3_CEBCA/192-231             ....TVDSQGPTPVCTPTFLERGKS.EVTEMNEDD.TDNEIVSKQP.......
A0A3Q1CEA7_AMPOC/208-244             ....SMCSEDSTPVCTPSLLERRKS.---MVVDDD.ADDEIVVKMP.......
B5X6J4_SALSA/207-244                 ....STCSEDVTPVCTPSVLERRRS.--MKINEDD.SDCEIIIK--nt.....
#=GC SS_cons                         ....X--TTS------HHHHHHHHH.HHHH--GGG.GS-SEEESS-.......
#=GC seq_cons                        ....olsSQsPTPVCTPTFLERRKS...sphsDDD.cDsEIlhK.P.......
//
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