GenomeNet

Database: Pfam
Entry: zf-C2H2
LinkDB: zf-C2H2
Original site: zf-C2H2 
#=GF ID   zf-C2H2
#=GF AC   PF00096.28
#=GF DE   Zinc finger, C2H2 type
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Boehm S;0000-0002-9538-9279
#=GF AU   Sonnhammer ELL;0000-0002-9015-5588
#=GF AU   Gago F;0000-0002-3071-4878
#=GF SE   Boehm S
#=GF GA   25.20 15.80;
#=GF TC   25.20 15.80;
#=GF NC   25.10 15.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Zinc_finger
#=GF CL   CL0361
#=GF RN   [1]
#=GF RM   9171100
#=GF RT   Variations of the C2H2 zinc finger motif in the yeast genome and
#=GF RT   classification of yeast zinc finger proteins. 
#=GF RA   Boehm S, Frishman D, Mewes HW; 
#=GF RL   Nucleic Acids Res 1997;25:2464-2469.
#=GF RN   [2]
#=GF RM   12683994
#=GF RT   Assessment by molecular dynamics simulations of the structural
#=GF RT   determinants of DNA-binding specificity for transcription factor
#=GF RT   Sp1. 
#=GF RA   Marco E, Garcia-Nieto R, Gago F; 
#=GF RL   J Mol Biol 2003;328:9-32.
#=GF DR   INTERPRO; IPR013087;
#=GF DR   PROSITE; PDOC00028;
#=GF DR   PRINTS; PR00048;
#=GF DR   SCOP; 1zaa; fa;
#=GF DR   HOMSTRAD; zf-CCHH;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The C2H2 zinc finger is the classical zinc finger domain. The
#=GF CC   two conserved cysteines and histidines co-ordinate a zinc ion.
#=GF CC   The following pattern describes the zinc finger.
#=GF CC   #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any
#=GF CC   amino acid, and numbers in brackets indicate the number of
#=GF CC   residues. The positions marked # are those that are important
#=GF CC   for the stable fold of the zinc finger. The final position can
#=GF CC   be either his or cys. The C2H2 zinc finger is composed of two
#=GF CC   short beta strands followed by an alpha helix. The amino
#=GF CC   terminal part of the helix binds the major groove in DNA binding
#=GF CC   zinc fingers. The accepted consensus binding sequence for Sp1 is
#=GF CC   usually defined by the asymmetric hexanucleotide core GGGCGG but
#=GF CC   this sequence does not include, among others, the GAG (=CTC)
#=GF CC   repeat that constitutes a high-affinity  site for Sp1 binding to
#=GF CC   the wt1 promoter [2].
#=GF SQ   896125
#=GS F7EWL9_MONDO/496-518        AC F7EWL9.2
#=GS A0A2J7Q2M3_9NEOP/99-121     AC A0A2J7Q2M3.1
#=GS A0A2Y9R9J0_TRIMA/520-542    AC A0A2Y9R9J0.1
#=GS A0A091CPK1_FUKDA/475-497    AC A0A091CPK1.1
#=GS A0A5F7ZDX8_MACMU/635-657    AC A0A5F7ZDX8.1
#=GS A0A4W6F6D6_LATCA/192-214    AC A0A4W6F6D6.1
#=GS A0A0L7R670_9HYME/476-499    AC A0A0L7R670.1
#=GS A0A455AT52_PHYMC/258-280    AC A0A455AT52.1
#=GS A0A2K5SI22_CEBCA/447-469    AC A0A2K5SI22.1
#=GS A0A484BFN4_DRONA/424-446    AC A0A484BFN4.1
#=GS A0A3P8YAJ1_ESOLU/468-490    AC A0A3P8YAJ1.2
#=GS K7JH19_NASVI/444-466        AC K7JH19.1
#=GS A0A2R9A6K6_PANPA/323-345    AC A0A2R9A6K6.1
#=GS A0A3Q2DZ36_CYPVA/375-397    AC A0A3Q2DZ36.1
#=GS ZNF22_MOUSE/139-161         AC Q9ERU3.2
#=GS A0A3Q0DW92_CARSF/525-547    AC A0A3Q0DW92.1
#=GS A0A091NHX0_APAVI/94-116     AC A0A091NHX0.1
#=GS F1SN91_PIG/392-414          AC F1SN91.3
#=GS A0A2Y9S107_TRIMA/333-355    AC A0A2Y9S107.1
#=GS A0A2G5B1Q5_COERN/22-46      AC A0A2G5B1Q5.1
#=GS A0A2G9QC09_LITCT/217-239    AC A0A2G9QC09.1
#=GS A0A670HRV0_PODMU/821-843    AC A0A670HRV0.1
#=GS A0A673ZDG2_SALTR/428-450    AC A0A673ZDG2.1
#=GS A0A1S3JPN1_LINUN/535-560    AC A0A1S3JPN1.1
#=GS A0A6G0IGP2_LARCR/380-402    AC A0A6G0IGP2.1
#=GS K7ETV8_PONAB/308-330        AC K7ETV8.1
#=GS A0A673W1D1_SALTR/258-280    AC A0A673W1D1.1
#=GS A0A2I3G259_NOMLE/917-940    AC A0A2I3G259.1
#=GS G3I726_CRIGR/500-522        AC G3I726.1
#=GS A0A093RRB2_PYGAD/117-139    AC A0A093RRB2.1
#=GS B3MKK8_DROAN/981-1003       AC B3MKK8.2
#=GS E1BHF3_BOVIN/380-402        AC E1BHF3.3
#=GS C3XWU1_BRAFL/10-32          AC C3XWU1.1
#=GS A0A2Y9I4L2_NEOSC/440-462    AC A0A2Y9I4L2.1
#=GS A0A2K5RL34_CEBCA/603-625    AC A0A2K5RL34.1
#=GS A0A3Q3AJ21_KRYMA/372-394    AC A0A3Q3AJ21.1
#=GS A0A2Y9PTL2_DELLE/822-846    AC A0A2Y9PTL2.1
#=GS A0A087YBN1_POEFO/276-298    AC A0A087YBN1.2
#=GS A0A6I8V1T3_DROPS/696-719    AC A0A6I8V1T3.1
#=GS A0A3Q7SIS9_VULVU/413-436    AC A0A3Q7SIS9.1
#=GS A0A452SBN5_URSAM/329-351    AC A0A452SBN5.1
#=GS A0A452SEE8_URSAM/87-109     AC A0A452SEE8.1
#=GS A0A4W5LWQ3_9TELE/564-586    AC A0A4W5LWQ3.1
#=GS A0A498M6J8_LABRO/622-644    AC A0A498M6J8.1
#=GS A0A1S3RXB5_SALSA/269-291    AC A0A1S3RXB5.1
#=GS A0A384BKE1_URSMA/466-488    AC A0A384BKE1.1
#=GS A0A2P8ZF57_BLAGE/135-157    AC A0A2P8ZF57.1
#=GS A2A799_MOUSE/285-307        AC A2A799.1
#=GS A0A218UUQ2_9PASE/206-229    AC A0A218UUQ2.1
#=GS A0A084WPS3_ANOSI/71-93      AC A0A084WPS3.1
#=GS A0A1B7TE53_9ASCO/119-141    AC A0A1B7TE53.1
#=GS A0A485PM37_LYNPA/510-532    AC A0A485PM37.1
#=GS A0A3B3ID19_ORYLA/112-134    AC A0A3B3ID19.1
#=GS A0A452GMG8_9SAUR/130-152    AC A0A452GMG8.1
#=GS A0A3B5R8N2_XIPMA/106-128    AC A0A3B5R8N2.1
#=GS A0A5N4A8W0_PHOPY/471-493    AC A0A5N4A8W0.1
#=GS A0A2K5EC50_AOTNA/449-470    AC A0A2K5EC50.1
#=GS A0A673A6J6_9TELE/117-139    AC A0A673A6J6.1
#=GS A0A673STN3_SURSU/231-253    AC A0A673STN3.1
#=GS A5DUH2_LODEL/139-162        AC A5DUH2.1
#=GS A0A2K6QC09_RHIRO/793-815    AC A0A2K6QC09.1
#=GS M3Y3Q5_MUSPF/503-525        AC M3Y3Q5.1
#=GS A0A4W2E2W3_BOBOX/653-675    AC A0A4W2E2W3.1
#=GS A0A2G9RV89_LITCT/190-212    AC A0A2G9RV89.1
#=GS A0A199UJ12_ANACO/265-290    AC A0A199UJ12.1
#=GS X1WDK1_DANRE/294-316        AC X1WDK1.1
#=GS A0A0L8G402_OCTBM/248-270    AC A0A0L8G402.1
#=GS A0A653C6Q1_CALMS/433-455    AC A0A653C6Q1.1
#=GS J9LQQ8_ACYPI/31-53          AC J9LQQ8.2
#=GS A0A3Q2ZZZ1_KRYMA/235-257    AC A0A3Q2ZZZ1.1
#=GS A0A6G1B518_CROCR/241-265    AC A0A6G1B518.1
#=GS A0A4W2DV82_BOBOX/655-677    AC A0A4W2DV82.1
#=GS A0A340Y7P2_LIPVE/604-626    AC A0A340Y7P2.1
#=GS A0A0L8FV23_OCTBM/59-81      AC A0A0L8FV23.1
#=GS A0A673U096_SURSU/456-478    AC A0A673U096.1
#=GS A0A0L8HSF2_OCTBM/510-532    AC A0A0L8HSF2.1
#=GS A0A674DKT2_SALTR/209-231    AC A0A674DKT2.1
#=GS A0A2G8LIM9_STIJA/66-88      AC A0A2G8LIM9.1
#=GS F7B6R4_MONDO/435-457        AC F7B6R4.2
#=GS A0A096NWH9_PAPAN/487-509    AC A0A096NWH9.2
#=GS A0A4W6F0V1_LATCA/657-679    AC A0A4W6F0V1.1
#=GS A0A0G2KC95_DANRE/120-142    AC A0A0G2KC95.1
#=GS A0A369JNC6_HYPMA/463-485    AC A0A369JNC6.1
#=GS G7MIW1_MACMU/594-616        AC G7MIW1.1
#=GS H2R1B3_PANTR/431-453        AC H2R1B3.1
#=GS A0A674DET4_SALTR/81-103     AC A0A674DET4.1
#=GS L8HW44_9CETA/362-384        AC L8HW44.1
#=GS A0A2R2MMH6_LINUN/212-234    AC A0A2R2MMH6.1
#=GS V4BAL9_LOTGI/51-73          AC V4BAL9.1
#=GS A0A670KCC4_PODMU/417-439    AC A0A670KCC4.1
#=GS A0A2K5LW78_CERAT/656-678    AC A0A2K5LW78.1
#=GS A6QQT2_BOVIN/579-601        AC A6QQT2.1
#=GS H0WE53_DANRE/150-172        AC H0WE53.1
#=GS U3KNC1_RABIT/301-323        AC U3KNC1.2
#=GS A0A315W6V4_GAMAF/243-267    AC A0A315W6V4.1
#=GS H0VB87_CAVPO/321-343        AC H0VB87.2
#=GS F7GMR6_CALJA/346-368        AC F7GMR6.3
#=GS A0A3Q1EMJ6_9TELE/245-267    AC A0A3Q1EMJ6.1
#=GS A0A1U7SVX9_ALLSI/240-262    AC A0A1U7SVX9.2
#=GS A0A3P9D408_9CICH/463-485    AC A0A3P9D408.1
#=GS S7PCI1_MYOBR/512-534        AC S7PCI1.1
#=GS A0A6A5FQ94_PERFL/312-335    AC A0A6A5FQ94.1
#=GS K8F4A0_9CHLO/146-168        AC K8F4A0.1
#=GS B4GST2_DROPE/452-472        AC B4GST2.1
#=GS A0A5J5N0B3_MUNRE/421-443    AC A0A5J5N0B3.1
#=GS F6YDZ6_MONDO/475-497        AC F6YDZ6.3
#=GS A0A2G9QJL0_LITCT/160-182    AC A0A2G9QJL0.1
#=GS A0A672HYN3_SALFA/204-226    AC A0A672HYN3.1
#=GS A0A0L8FSH2_OCTBM/198-220    AC A0A0L8FSH2.1
#=GS A0A2K5HUZ4_COLAP/308-330    AC A0A2K5HUZ4.1
#=GS E0VCZ9_PEDHC/725-747        AC E0VCZ9.1
#=GS A0A2K6LPH2_RHIBE/277-299    AC A0A2K6LPH2.1
#=GS A0A5N5NYL7_9PEZI/79-101     AC A0A5N5NYL7.1
#=GS A0A4W6FAN9_LATCA/916-938    AC A0A4W6FAN9.1
#=GS ZNF43_HUMAN/734-756         AC P17038.4
#=GS A0A3Q7VC04_URSAR/425-447    AC A0A3Q7VC04.1
#=GS J9JWR5_ACYPI/521-543        AC J9JWR5.2
#=GS A0A1L1RMB1_CHICK/334-356    AC A0A1L1RMB1.2
#=GS A0A2G9Q9V7_LITCT/131-153    AC A0A2G9Q9V7.1
#=GS A0A3Q7XD35_URSAR/367-389    AC A0A3Q7XD35.1
#=GS I3N8Y0_ICTTR/499-521        AC I3N8Y0.2
#=GS A0A671F1R9_RHIFE/427-449    AC A0A671F1R9.1
#=GS A0A2I4BU78_9TELE/243-265    AC A0A2I4BU78.1
#=GS A0A667XED1_9TELE/149-171    AC A0A667XED1.1
#=GS A0A3Q7TBD8_VULVU/207-229    AC A0A3Q7TBD8.1
#=GS A0A286ZK54_PIG/474-496      AC A0A286ZK54.2
#=GS A0A096NPT9_PAPAN/494-516    AC A0A096NPT9.2
#=GS A0A2U4AU31_TURTR/482-504    AC A0A2U4AU31.1
#=GS A0A2A2M0C6_9BILA/37-59      AC A0A2A2M0C6.1
#=GS A0A2I3LGC3_PAPAN/455-477    AC A0A2I3LGC3.1
#=GS A0A674F465_SALTR/571-593    AC A0A674F465.1
#=GS A0A2K6Q4Y2_RHIRO/268-290    AC A0A2K6Q4Y2.1
#=GS A0A1X6P9B5_PORUM/481-503    AC A0A1X6P9B5.1
#=GS A0A3M0JSA4_HIRRU/357-379    AC A0A3M0JSA4.1
#=GS A0A087XP33_POEFO/393-415    AC A0A087XP33.2
#=GS A0A074SAN8_9AGAM/235-259    AC A0A074SAN8.1
#=GS A0A5A9NAD2_9TELE/443-465    AC A0A5A9NAD2.1
#=GS A0A452FUM3_CAPHI/514-536    AC A0A452FUM3.1
#=GS A0A0L8I5E4_OCTBM/240-262    AC A0A0L8I5E4.1
#=GS A0A340XCK9_LIPVE/633-655    AC A0A340XCK9.1
#=GS A0A096P473_PAPAN/495-517    AC A0A096P473.2
#=GS A0A3N0XQY7_ANAGA/405-427    AC A0A3N0XQY7.1
#=GS I3K1T0_ORENI/175-197        AC I3K1T0.2
#=GS A0A0L8I5G5_OCTBM/263-285    AC A0A0L8I5G5.1
#=GS A0A2I0MG85_COLLI/128-150    AC A0A2I0MG85.1
#=GS A0A2Y9J5V4_ENHLU/330-352    AC A0A2Y9J5V4.1
#=GS A0A2U3ZCM5_ODORO/229-251    AC A0A2U3ZCM5.1
#=GS A0A067QUM5_ZOONE/554-576    AC A0A067QUM5.1
#=GS A0A0L0HEL5_SPIPD/35-58      AC A0A0L0HEL5.1
#=GS R4GCZ1_ANOCA/507-529        AC R4GCZ1.1
#=GS L5LIQ2_MYODS/253-275        AC L5LIQ2.1
#=GS A0A2K5D386_AOTNA/265-287    AC A0A2K5D386.1
#=GS A0A674CPF5_SALTR/250-270    AC A0A674CPF5.1
#=GS W4Y8Y7_STRPU/493-515        AC W4Y8Y7.1
#=GS A0A1U8CNE6_MESAU/510-532    AC A0A1U8CNE6.2
#=GS A0A1D1USA7_RAMVA/354-377    AC A0A1D1USA7.1
#=GS K7F348_PELSI/375-397        AC K7F348.1
#=GS G5B7L3_HETGA/51-73          AC G5B7L3.1
#=GS A0A674DF04_SALTR/7-30       AC A0A674DF04.1
#=GS A0A653BJK7_CALMS/543-565    AC A0A653BJK7.1
#=GS G3RDY2_GORGO/356-378        AC G3RDY2.2
#=GS L5KV85_PTEAL/168-190        AC L5KV85.1
#=GS A0A093NGY3_PYGAD/530-552    AC A0A093NGY3.1
#=GS Q6WGJ9_NEMVE/208-230        AC Q6WGJ9.1
#=GS A0A2I2YX66_GORGO/291-313    AC A0A2I2YX66.1
#=GS D2HRB7_AILME/393-415        AC D2HRB7.1
#=GS A0A673A1B1_9TELE/1466-1489  AC A0A673A1B1.1
#=GS A0A670KFA5_PODMU/173-195    AC A0A670KFA5.1
#=GS F6SQ90_HORSE/376-398        AC F6SQ90.2
#=GS A0A6G0U7D5_APHGL/313-335    AC A0A6G0U7D5.1
#=GS A0A2K5IHV4_COLAP/595-617    AC A0A2K5IHV4.1
#=GS F6VH92_MONDO/501-523        AC F6VH92.2
#=GS A0A2K5MHN8_CERAT/307-329    AC A0A2K5MHN8.1
#=GS A0A0L8FFJ0_OCTBM/82-104     AC A0A0L8FFJ0.1
#=GS A0A674AEM7_SALTR/157-179    AC A0A674AEM7.1
#=GS A0A2I3T9V9_PANTR/544-566    AC A0A2I3T9V9.1
#=GS A0A3Q3FLH9_9LABR/279-301    AC A0A3Q3FLH9.1
#=GS H2Y5B4_CIOSA/453-475        AC H2Y5B4.1
#=GS A0A0N4STU4_DANRE/80-102     AC A0A0N4STU4.2
#=GS A0A2I3LEQ1_PAPAN/273-295    AC A0A2I3LEQ1.1
#=GS A0A0L8FIX9_OCTBM/396-418    AC A0A0L8FIX9.1
#=GS L8Y7X3_TUPCH/325-347        AC L8Y7X3.1
#=GS A0A2R8Q568_DANRE/101-123    AC A0A2R8Q568.1
#=GS A0A3S2NL31_CHISP/290-312    AC A0A3S2NL31.1
#=GS A0A2K6UID7_SAIBB/265-287    AC A0A2K6UID7.1
#=GS T1GC17_MEGSC/351-373        AC T1GC17.1
#=GS A0A4W5PKC2_9TELE/1084-1105  AC A0A4W5PKC2.1
#=GS A0A341DDS4_NEOAA/232-254    AC A0A341DDS4.1
#=GS A0A672ZJW6_9TELE/77-99      AC A0A672ZJW6.1
#=GS A0A3B1JFW3_ASTMX/370-394    AC A0A3B1JFW3.1
#=GS A0A2J7R2P7_9NEOP/300-322    AC A0A2J7R2P7.1
#=GS A0A6A4JJ25_APOLU/122-144    AC A0A6A4JJ25.1
#=GS F1PQQ8_CANLF/281-303        AC F1PQQ8.3
#=GS A0A2G9RU94_LITCT/777-799    AC A0A2G9RU94.1
#=GS H2PRD8_PONAB/235-257        AC H2PRD8.1
#=GS V2XBU2_MONRO/48-73          AC V2XBU2.1
#=GS A0A3Q3KF40_9TELE/356-378    AC A0A3Q3KF40.1
#=GS A0A2K6NB98_RHIRO/528-550    AC A0A2K6NB98.1
#=GS A0A482V7K5_9CUCU/443-466    AC A0A482V7K5.1
#=GS A0A5F8H8E6_MONDO/151-173    AC A0A5F8H8E6.1
#=GS A0A2K6P273_RHIRO/351-373    AC A0A2K6P273.1
#=GS A0A177WKD4_BATDL/214-236    AC A0A177WKD4.1
#=GS A0A667W8X8_9TELE/176-198    AC A0A667W8X8.1
#=GS A0A2K6MGT1_RHIBE/312-334    AC A0A2K6MGT1.1
#=GS A0A452QHN3_URSAM/460-482    AC A0A452QHN3.1
#=GS A0A1U8CY88_MESAU/427-449    AC A0A1U8CY88.1
#=GS A0A437BYH7_ORYJA/422-444    AC A0A437BYH7.1
#=GS A0A4W6F0V1_LATCA/296-318    AC A0A4W6F0V1.1
#=GS OSR1_XENTR/196-218          AC Q66JF8.1
#=GS J9L823_ACYPI/482-504        AC J9L823.2
#=GS A0A0L8HVK7_OCTBM/119-141    AC A0A0L8HVK7.1
#=GS A0A6A5DIE6_SCHHA/594-616    AC A0A6A5DIE6.1
#=GS A0A340X0P3_LIPVE/400-422    AC A0A340X0P3.1
#=GS A0A673V4S4_SURSU/383-405    AC A0A673V4S4.1
#=GS S7PB44_MYOBR/380-402        AC S7PB44.1
#=GS A0A671XR24_SPAAU/662-684    AC A0A671XR24.1
#=GS A0A2K5TV88_MACFA/228-250    AC A0A2K5TV88.1
#=GS A0A672ZXC4_9TELE/394-416    AC A0A672ZXC4.1
#=GS F1SH30_PIG/232-254          AC F1SH30.3
#=GS G1QLB7_NOMLE/132-154        AC G1QLB7.2
#=GS A0A5F5XVK6_FELCA/222-244    AC A0A5F5XVK6.1
#=GS A0A3Q3MD40_9TELE/881-902    AC A0A3Q3MD40.1
#=GS A0A3Q7SMC3_VULVU/939-961    AC A0A3Q7SMC3.1
#=GS A0A2I3TR30_PANTR/136-158    AC A0A2I3TR30.1
#=GS F0ZPG0_DICPU/119-141        AC F0ZPG0.1
#=GS A0A1L8FUS0_XENLA/530-552    AC A0A1L8FUS0.1
#=GS A0A5F4VRS2_CALJA/162-184    AC A0A5F4VRS2.1
#=GS A0A673YQ68_SALTR/236-258    AC A0A673YQ68.1
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#=GS C3ZDJ9_BRAFL/10-32          AC C3ZDJ9.1
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#=GS KLF8_HUMAN/304-328          AC O95600.2
#=GS H2QH86_PANTR/138-160        AC H2QH86.2
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#=GS W5P3F1_SHEEP/320-342        AC W5P3F1.1
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#=GS A0A0Q9WZM2_DROMO/363-385    AC A0A0Q9WZM2.1
#=GS A0A0L8GAL4_OCTBM/308-330    AC A0A0L8GAL4.1
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#=GS A0A2K6PPH5_RHIRO/469-491    AC A0A2K6PPH5.1
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#=GS A0A2R8ZUC4_PANPA/511-533    AC A0A2R8ZUC4.1
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