GenomeNet

Database: Pfam
Entry: zf-RAG1
LinkDB: zf-RAG1
Original site: zf-RAG1 
#=GF ID   zf-RAG1
#=GF AC   PF10426.10
#=GF DE   Recombination-activating protein 1 zinc-finger domain
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Gene3D, pdb_1rmd
#=GF GA   22.00 22.00;
#=GF TC   22.30 22.60;
#=GF NC   21.80 21.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   9228952
#=GF RT   Crystal structure of the RAG1 dimerization domain reveals
#=GF RT   multiple zinc-binding motifs including a novel zinc binuclear
#=GF RT   cluster. 
#=GF RA   Bellon SF, Rodgers KK, Schatz DG, Coleman JE, Steitz TA; 
#=GF RL   Nat Struct Biol. 1997;4:586-591.
#=GF DR   INTERPRO; IPR019485;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a C2-H2 zinc-finger domain closely resembling the
#=GF CC   classical TFIIIA-type zinc-finger, CX3FX5LX2-3H, despite having
#=GF CC   a valine and a tyrosine at the core instead of a phenylalanine
#=GF CC   and a leucine, hence CX3VX1LX2YX2H.  The structure,
#=GF CC   nevertheless, contains the characteristic two-stranded
#=GF CC   beta-sheet and alpha-helix of a classical zinc-finger. The
#=GF CC   domain binds one zinc and, in complex with the zinc-RING-finger
#=GF CC   domain, helps to stabilise the whole of the dimerisation region
#=GF CC   of recombination activating protein 1 (RAG1) [1]. The function
#=GF CC   of the whole is to bind double-stranded DNA.
#=GF SQ   104
#=GS A0A384A1T6_BALAS/354-383  AC A0A384A1T6.1
#=GS R0LZS8_ANAPL/350-379      AC R0LZS8.1
#=GS A0A2I0MPH0_COLLI/344-373  AC A0A2I0MPH0.1
#=GS H0W9U1_CAVPO/354-383      AC H0W9U1.1
#=GS G1NTJ5_MYOLU/354-383      AC G1NTJ5.1
#=GS G1TU62_RABIT/353-382      AC G1TU62.1
#=GS Q28463_MONDO/358-387      AC Q28463.1
#=GS M3Z8B8_MUSPF/354-383      AC M3Z8B8.1
#=GS U3IW73_ANAPP/350-379      AC U3IW73.1
#=GS H2M917_ORYLA/323-351      AC H2M917.2
#=GS A0A1L8GIM4_XENLA/355-384  AC A0A1L8GIM4.1
#=GS A0A1S3FEP4_DIPOR/354-383  AC A0A1S3FEP4.1
#=GS A0A452EFW4_CAPHI/354-383  AC A0A452EFW4.1
#=GS A0A401S7R4_CHIPU/360-389  AC A0A401S7R4.1
#=GS A0A2I3RIF0_PANTR/354-383  AC A0A2I3RIF0.1
#=GS RAG1_RABIT/353-382        AC P34088.1
#=GS A0A099Z620_TINGU/351-380  AC A0A099Z620.1
#=GS A0A2K6NRR9_RHIRO/354-383  AC A0A2K6NRR9.1
#=GS G5B131_HETGA/355-384      AC G5B131.1
#=GS A0A2R9CSL6_PANPA/354-383  AC A0A2R9CSL6.1
#=GS A0A3B3C101_ORYME/309-336  AC A0A3B3C101.1
#=GS A0A2U3WKH9_ODORO/354-383  AC A0A2U3WKH9.1
#=GS RAG1_CHICK/350-379        AC P24271.1
#=GS A0A091I8R8_CALAN/340-369  AC A0A091I8R8.1
#=GS A0A096N450_PAPAN/354-383  AC A0A096N450.1
#=GS A0A0D9QZL1_CHLSB/354-383  AC A0A0D9QZL1.1
#=GS A0A2K5HAC0_COLAP/354-383  AC A0A2K5HAC0.1
#=GS A0A2K6K332_RHIBE/354-383  AC A0A2K6K332.1
#=GS A0A2R8MLP7_CALJA/354-383  AC A0A2R8MLP7.1
#=GS A0A2Y9EQ27_PHYMC/354-383  AC A0A2Y9EQ27.1
#=GS W5PL78_SHEEP/354-383      AC W5PL78.1
#=GS A0A2K6S7R8_SAIBB/354-383  AC A0A2K6S7R8.1
#=GS A0A3M0JHE5_HIRRU/369-398  AC A0A3M0JHE5.1
#=GS H3A5N4_LATCH/353-382      AC H3A5N4.1
#=GS A0A2U3XZ32_LEPWE/354-383  AC A0A2U3XZ32.1
#=GS A0A226MQZ7_CALSU/389-418  AC A0A226MQZ7.1
#=GS A0A091CM61_FUKDA/126-155  AC A0A091CM61.1
#=GS A0A384BR25_URSMA/354-383  AC A0A384BR25.1
#=GS A0A2K5UF18_MACFA/354-383  AC A0A2K5UF18.1
#=GS G3V6K9_RAT/351-380        AC G3V6K9.1
#=GS L8YCQ6_TUPCH/153-182      AC L8YCQ6.1
#=GS A0A1U7SPR9_TARSY/354-383  AC A0A1U7SPR9.1
#=GS G3WMA4_SARHA/358-387      AC G3WMA4.1
#=GS A0A1U7THL9_TARSY/354-383  AC A0A1U7THL9.1
#=GS A0A1D5PU72_CHICK/350-379  AC A0A1D5PU72.1
#=GS A0A3Q7SXG0_VULVU/354-383  AC A0A3Q7SXG0.1
#=GS A0A2K5C5Z1_AOTNA/354-383  AC A0A2K5C5Z1.1
#=GS A0A452S6I0_URSAM/354-383  AC A0A452S6I0.1
#=GS A0A091W6F9_OPIHO/346-375  AC A0A091W6F9.1
#=GS A0A2Y9P7L1_DELLE/354-383  AC A0A2Y9P7L1.1
#=GS A0A2K5PMU9_CEBCA/354-383  AC A0A2K5PMU9.1
#=GS RAG1_MOUSE/351-380        AC P15919.2
#=GS RAG1_MOUSE/351-380        DR PDB; 1RMD A; 87-116;
#=GS A0A093I8M0_STRCA/351-380  AC A0A093I8M0.1
#=GS A0A1S2ZN11_ERIEU/353-382  AC A0A1S2ZN11.1
#=GS A0A091FX46_9AVES/346-375  AC A0A091FX46.1
#=GS A0A0A0A5Z8_CHAVO/346-375  AC A0A0A0A5Z8.1
#=GS G3UKA0_LOXAF/354-383      AC G3UKA0.1
#=GS G1NRN5_MELGA/351-380      AC G1NRN5.1
#=GS A0A091JRA9_EGRGA/346-375  AC A0A091JRA9.1
#=GS K7F194_PELSI/348-377      AC K7F194.1
#=GS A0A1V4KEB9_PATFA/344-373  AC A0A1V4KEB9.1
#=GS A0A1U8C9P5_MESAU/352-381  AC A0A1U8C9P5.1
#=GS I3MY25_ICTTR/354-383      AC I3MY25.1
#=GS G1S8G7_NOMLE/354-383      AC G1S8G7.1
#=GS A0A3Q7X0C1_URSAR/354-383  AC A0A3Q7X0C1.1
#=GS RAG1_PIG/354-383          AC Q867B5.1
#=GS A0A340Y5B9_LIPVE/354-383  AC A0A340Y5B9.1
#=GS A0A0P7YW53_SCLFO/480-509  AC A0A0P7YW53.1
#=GS F1MG60_BOVIN/354-383      AC F1MG60.2
#=GS M3VZD3_FELCA/354-383      AC M3VZD3.1
#=GS A0A401P966_SCYTO/352-381  AC A0A401P966.1
#=GS I3L7X1_PIG/354-383        AC I3L7X1.1
#=GS A0A2Y9JV89_ENHLU/354-383  AC A0A2Y9JV89.1
#=GS L5KYG5_PTEAL/397-426      AC L5KYG5.1
#=GS A0A1L8GE69_XENLA/355-384  AC A0A1L8GE69.1
#=GS A0A2I3T8S9_PANTR/354-383  AC A0A2I3T8S9.1
#=GS A0A1A6HQ99_NEOLE/400-429  AC A0A1A6HQ99.1
#=GS RAG1_HUMAN/354-383        AC P15918.2
#=GS E2RDF6_CANLF/354-383      AC E2RDF6.1
#=GS A0A151MBE1_ALLMI/345-374  AC A0A151MBE1.1
#=GS G7NDK1_MACMU/354-383      AC G7NDK1.1
#=GS H0ZIP6_TAEGU/350-379      AC H0ZIP6.1
#=GS D2HV49_AILME/354-383      AC D2HV49.1
#=GS U3KIY3_FICAL/350-379      AC U3KIY3.1
#=GS W5LZ93_LEPOC/356-385      AC W5LZ93.1
#=GS A0A2K6ARB2_MACNE/354-383  AC A0A2K6ARB2.1
#=GS A0A452H4I7_9SAUR/358-387  AC A0A452H4I7.1
#=GS A0A226PQ49_COLVI/351-380  AC A0A226PQ49.1
#=GS A0A2K5XFH0_MANLE/354-383  AC A0A2K5XFH0.1
#=GS A0A091F4N0_CORBR/365-394  AC A0A091F4N0.1
#=GS A0A093IWW8_DRYPU/346-375  AC A0A093IWW8.1
#=GS A0A2U3V9Q8_TURTR/354-383  AC A0A2U3V9Q8.1
#=GS A0A087R843_APTFO/346-375  AC A0A087R843.1
#=GS A0A2K5LZS8_CERAT/376-405  AC A0A2K5LZS8.1
#=GS A0A2I2ZGP8_GORGO/354-383  AC A0A2I2ZGP8.1
#=GS A0A2Y9D8H7_TRIMA/354-383  AC A0A2Y9D8H7.1
#=GS A0A0Q3LSI9_AMAAE/332-361  AC A0A0Q3LSI9.1
#=GS H2M914_ORYLA/394-422      AC H2M914.2
#=GS A0A218UYR9_9PASE/362-391  AC A0A218UYR9.1
#=GS F6WSB4_HORSE/353-382      AC F6WSB4.1
#=GS G1KDK1_ANOCA/355-384      AC G1KDK1.2
#=GS A0A402EZ55_9SAUR/366-395  AC A0A402EZ55.1
#=GS A0A091UWK0_NIPNI/346-375  AC A0A091UWK0.1
#=GS A0A093PU14_9PASS/346-375  AC A0A093PU14.1
A0A384A1T6_BALAS/354-383             ....LMVKCPAKECNEEVSLEKYNHHVSSHKESK..
R0LZS8_ANAPL/350-379                 ....LSIRCPVKECDEEILHGKYGQHLSSHKEMK..
A0A2I0MPH0_COLLI/344-373             ....LGIRCPVKECDEEILHGKYSQHLSSHKEMK..
H0W9U1_CAVPO/354-383                 ....LMVKCPAKECNEEVSLEKYNQHVLSHKESK..
G1NTJ5_MYOLU/354-383                 ....LMVKCPAQECNEEVSLEKYNHHVASHKDSK..
G1TU62_RABIT/353-382                 ....LIVKCSAPECNEEVSLEKYNHHVSSHKES-r.
Q28463_MONDO/358-387                 ....LVVRCPVKDCDKDVSLEKYNQHISSHKEPK..
M3Z8B8_MUSPF/354-383                 ....LMVKCPAKECNEEISLEKYNHHVSSHKESK..
U3IW73_ANAPP/350-379                 ....LSIRCPVKECDEEILHGKYGQHLSSHKEMK..
H2M917_ORYLA/323-351                 llll----CPSDGCDEEVRLDSIKAHCLSHK---le
A0A1L8GIM4_XENLA/355-384             ....LLLKCTVSGCDEEIPLGKYSHHISKHKETK..
A0A1S3FEP4_DIPOR/354-383             ....LLVKCPAKECNEEVSLEKYNHHVSSHKESK..
A0A452EFW4_CAPHI/354-383             ....LMVKCPAEECDEEVTLEKYNHHVSSHKESK..
A0A401S7R4_CHIPU/360-389             ....LVLKCPATDCEMEVRLGEYSNHAQNHKET-r.
A0A2I3RIF0_PANTR/354-383             ....LMVKCPAKECNEEVSLEKYNHHISSHKESK..
RAG1_RABIT/353-382                   ....LIVKCSAPECNEEVSLEKYNHHVSSHKES-r.
A0A099Z620_TINGU/351-380             ....LGIRCPVKECDEEIMLGKYGQHLSSHKLMK..
A0A2K6NRR9_RHIRO/354-383             ....LMVKCPAKECNQEISLEKYNHHVSSHKESK..
G5B131_HETGA/355-384                 ....LMVKCPAKECSEEVSLEKYNQHVSSHKESK..
A0A2R9CSL6_PANPA/354-383             ....LMVKCPAKECNEEVSLEKYNHHISSHKESK..
A0A3B3C101_ORYME/309-336             .lll---LCPSDGCDEEVRLDSIKAHCLSHK---l.
A0A2U3WKH9_ODORO/354-383             ....LMVKCPAKECNEEVSLEKYNHHVSSHKESK..
RAG1_CHICK/350-379                   ....LSIRCPVPECDEEILHGKYGQHFSNHKEMK..
A0A091I8R8_CALAN/340-369             ....LRVRCPVKECDEEILHGKYGQHLSNHKEMK..
A0A096N450_PAPAN/354-383             ....LKVKCPAKECNQEVSLEKYNHHISSHKESK..
A0A0D9QZL1_CHLSB/354-383             ....LMVKCPAKECNQEVSLEKYNHHVSSHKESK..
A0A2K5HAC0_COLAP/354-383             ....LMVKCPAKECNQEISLEKYNHHVSSHKESK..
A0A2K6K332_RHIBE/354-383             ....LMVKCPAKECNQEISLEKYNHHVSSHKESK..
A0A2R8MLP7_CALJA/354-383             ....LMVKCPAQECNEVVSLEKYNHHISSHKESK..
A0A2Y9EQ27_PHYMC/354-383             ....LTVKCPAKECNEEVSLEKYNHHVSSHKESK..
W5PL78_SHEEP/354-383                 ....LMVKCPAEECDEEVTLEKYNHHVSSHKESK..
A0A2K6S7R8_SAIBB/354-383             ....LMVRCPAKECNEVVSLEKYNHHISSHKESK..
A0A3M0JHE5_HIRRU/369-398             ....LSIRCPVKECDEEILHGKYGQHLSSHKEMK..
H3A5N4_LATCH/353-382                 ....LMVKCPAKECDEQVRLEEYSSHSQSHKEVK..
A0A2U3XZ32_LEPWE/354-383             ....LMVKCPAKECNEEVSLEKYNHHVSSHKESK..
A0A226MQZ7_CALSU/389-418             ....LSIRCPVPECDEEILHGKYSQHFSNHKEMK..
A0A091CM61_FUKDA/126-155             ....LMVKCPAKECSEEVSLEKYNQHISSHKES-r.
A0A384BR25_URSMA/354-383             ....LMVKCPAKECNEEVSLEKYNHHVSSHKESK..
A0A2K5UF18_MACFA/354-383             ....LMVKCPAKECNQEVSLEKYNHHISSHKESK..
G3V6K9_RAT/351-380                   ....LMVKCPAQECNEEVSLEKYNHHVSSHKESK..
L8YCQ6_TUPCH/153-182                 ....LVVRCPAKECSEEVSLEKYNHHVSSHKESK..
A0A1U7SPR9_TARSY/354-383             ....LIVKCPAKECNEEISLEKYNHHVSSHKDSK..
G3WMA4_SARHA/358-387                 ....LLVKCPVNDCDKEVSFEKYNQHISSHKEPK..
A0A1U7THL9_TARSY/354-383             ....LIVKCPAKECNEEISLEKYNHHVSSHKDSK..
A0A1D5PU72_CHICK/350-379             ....LSIRCPVPECDEEILHGKYGQHFSNHKEMK..
A0A3Q7SXG0_VULVU/354-383             ....LMVKCPAKGCDEEVSLERYNQHVAGHKD--sd
A0A2K5C5Z1_AOTNA/354-383             ....LMVKCPAQECNEVVSLEKYNHHISSHKESK..
A0A452S6I0_URSAM/354-383             ....LMVKCPAKECNEEVSLEKYNHHVSSHKESK..
A0A091W6F9_OPIHO/346-375             ....LGIRCPIKECDEEILYGKYSQHLSSHKEMK..
A0A2Y9P7L1_DELLE/354-383             ....LMVKCPAKECNEEVSLEKYNHHVSSHKESK..
A0A2K5PMU9_CEBCA/354-383             ....LMVKCPAKECNEVVSLEKYNHHISSHKESK..
RAG1_MOUSE/351-380                   ....LMVKCPAQDCNEEVSLEKYNHHVSSHKESK..
#=GR RAG1_MOUSE/351-380        SS    ....-EEE--STT---EEEHHHHHHHHHTS----..
A0A093I8M0_STRCA/351-380             ....LGIRCSVKECDEEILLGKYSQHLSSHKEMK..
A0A1S2ZN11_ERIEU/353-382             ....LLVKCPAKGCNEEVSLEKYNHHVSSHKESK..
A0A091FX46_9AVES/346-375             ....LAVRCPVKECDEEILHGKYGQHLSSHKETK..
A0A0A0A5Z8_CHAVO/346-375             ....LGIRCPVKECDEEILHGKYGQHLSSHKEMK..
G3UKA0_LOXAF/354-383                 ....LMVKCPAKECSEEVSLEKYNHHVSSHKESK..
G1NRN5_MELGA/351-380                 ....LSIRCPVPECDEEILYGKYGQHFSNHKEMK..
A0A091JRA9_EGRGA/346-375             ....LGIRCPVKECDEEVLHGKYGQHLSSHKEMK..
K7F194_PELSI/348-377                 ....LAVRCPVKECDEEVLLGKYCHHLSSHKELK..
A0A1V4KEB9_PATFA/344-373             ....LSIRCPVKECDEEILYGKYSQHLSSHKEMK..
A0A1U8C9P5_MESAU/352-381             ....LVVKCPAQECNEEVSLEKYNHHVSSHKESK..
I3MY25_ICTTR/354-383                 ....LVVKCPAEECNEEISLEKYNHHVSSHKESK..
G1S8G7_NOMLE/354-383                 ....LTVKCPAKECNEEVSLEKYNHHISSHKESK..
A0A3Q7X0C1_URSAR/354-383             ....LMVKCPAKECNEEVSLEKYNHHVSSHKESK..
RAG1_PIG/354-383                     ....LMVKCPAKECNEEISLEKYNHHISSHKESK..
A0A340Y5B9_LIPVE/354-383             ....LMVKCPAKECNEEVSLEKYNHHVSSHKDSK..
A0A0P7YW53_SCLFO/480-509             ....LLLRCPREDCREAVRLESFGSHCRGHQE--ad
F1MG60_BOVIN/354-383                 ....LMVKCPAEECDEEVSLEKYNHHVSSHKESK..
M3VZD3_FELCA/354-383                 ....LMVRCPAKECNEEVSLEKYNHHVSSHKESK..
A0A401P966_SCYTO/352-381             ....LVLRCPVTDCEVEVRLGEYSTHALDHKE--rr
I3L7X1_PIG/354-383                   ....LMVKCPAKECNEEISLEKYNHHISSHKESK..
A0A2Y9JV89_ENHLU/354-383             ....LMVKCPAKECNKEISLEKYNHHVSSHKESK..
L5KYG5_PTEAL/397-426                 ....LMVKCPAQECNEEVSLEKYNHHVSSHKDSK..
A0A1L8GE69_XENLA/355-384             ....LLLKCTVSGCDEEISLGKYSHHISKHKETK..
A0A2I3T8S9_PANTR/354-383             ....LMVKCPAKECNEEVSLEKYNHHISSHKESK..
A0A1A6HQ99_NEOLE/400-429             ....LTVKCPAQECNEEVSLEKYNHHVSSHKESK..
RAG1_HUMAN/354-383                   ....LMVKCPAKECNEEVSLEKYNHHISSHKESK..
E2RDF6_CANLF/354-383                 ....LMVRCPAKGCDEEVSLERYNQHVAGHKD--sd
A0A151MBE1_ALLMI/345-374             ....LTLRCPVKECDEEILLGKYGQHLPSHKELK..
G7NDK1_MACMU/354-383                 ....LMVKCPAKECNQEVSLEKYNHHISSHKESK..
H0ZIP6_TAEGU/350-379                 ....LNIRCPVKECDEEISHGKYGQHLSGHKEMK..
D2HV49_AILME/354-383                 ....LMVKCPAKECNEEVSLEKYNRHVSSHKESK..
U3KIY3_FICAL/350-379                 ....LGIRCPVKECDEEIMHGKYGQHLSGHKEMK..
W5LZ93_LEPOC/356-385                 ....LVIRCPAQDCDEHVRLEDYGAHTLSHQE--gq
A0A2K6ARB2_MACNE/354-383             ....LMVKCPAKECNQEVSLEKYNHHILSHKESK..
A0A452H4I7_9SAUR/358-387             ....LAVRCPVKECDEEVLLGKYCHHLSSHKEVK..
A0A226PQ49_COLVI/351-380             ....LSIRCPVPECDEEILHGKYSQHFSNHKEMK..
A0A2K5XFH0_MANLE/354-383             ....LMVKCPAKECNQEVSLEKYNHHISSHKESK..
A0A091F4N0_CORBR/365-394             ....LSIRCPVKECDEEILHGKYGQHLSSHKEMK..
A0A093IWW8_DRYPU/346-375             ....LSIRCPVKECDEEISHGKYGQHLSSHKEMK..
A0A2U3V9Q8_TURTR/354-383             ....LMVKCPAKECNEEVSLEKYNHHVSSHKESK..
A0A087R843_APTFO/346-375             ....LGIRCPVKECDEEILHGKYGQHLSSHKEMK..
A0A2K5LZS8_CERAT/376-405             ....LMVKCPAKECNQEVSLEKYNHHISSHKESK..
A0A2I2ZGP8_GORGO/354-383             ....LMVKCPAKECNEEVSLEKYNHHISSHKESK..
A0A2Y9D8H7_TRIMA/354-383             ....LMVKCPSKECNEEVSLEKYNHHVASHKESK..
A0A0Q3LSI9_AMAAE/332-361             ....LGIRCTVKECDEEILHEKYGQHLSSHKEMK..
H2M914_ORYLA/394-422                 llll----CPSDGCDEEVRLDSIKAHCLSHK---le
A0A218UYR9_9PASE/362-391             ....LNIRCPVKECDEEISHGKYGQHLSGHKEMK..
F6WSB4_HORSE/353-382                 ....LMVKCPAEECNEEVSLEKYNHHVSSHKESK..
G1KDK1_ANOCA/355-384                 ...lPVI-CPVKDCQEEICLGKYCHHLSIHKEIK..
A0A402EZ55_9SAUR/366-395             ....LGVKCPVKDCHEEVTLGKYSHHLSSHKEKK..
A0A091UWK0_NIPNI/346-375             ....LGIRCPVKECDEEILHGKYGQHLSSHKEMK..
A0A093PU14_9PASS/346-375             ....LGIRCPVKECDEEILHGKYGQHLSSHKEMK..
#=GC SS_cons                         ....-EEE--STT---EEEHHHHHHHHHTS----..
#=GC seq_cons                        ....LhVKCPAKECsEEVSLEKYNpHlSSHKEoK..
//
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