GenomeNet

Database: Pfam
Entry: zf_C2H2_10
LinkDB: zf_C2H2_10
Original site: zf_C2H2_10 
#=GF ID   zf_C2H2_10
#=GF AC   PF18414.1
#=GF DE   C2H2 type zinc-finger 
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF02232
#=GF GA   25.60 25.60;
#=GF TC   25.60 25.70;
#=GF NC   25.40 25.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   18313693
#=GF RT   Solution structure of NEMO zinc finger and impact of an
#=GF RT   anhidrotic ectodermal dysplasia with immunodeficiency-related
#=GF RT   point mutation.
#=GF RA   Cordier F, Vinolo E, Veron M, Delepierre M, Agou F;
#=GF RL   J Mol Biol. 2008;377:1419-1432.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a zinc finger domain C2H2 which can be found in
#=GF CC   optineurin (optic neuropathy inducing protein) and NF-kappa-B
#=GF CC   essential modulator (NEMO) furthermore, it can be found in
#=GF CC   kinase TBK1, a member of the IKK (inhibitor of nuclear factor
#=GF CC   kappa-B kinase) family. The C-terminal region, which carries the
#=GF CC   zinc finger domain, constitutes the regulatory domain of NEMO,
#=GF CC   as it receives the activation signal from upstream molecules,
#=GF CC   and subsequently transmits this activation to the kinases bound
#=GF CC   to the N-terminal domain. The isolated NEMO zinc finger is
#=GF CC   thought to be involved in protein-protein rather than
#=GF CC   protein-DNA interaction [1].
#=GF SQ   242
#=GS F7DVK0_XENTR/481-506      AC F7DVK0.1
#=GS A0A2I2YWZ1_GORGO/294-319  AC A0A2I2YWZ1.1
#=GS A0A1U8DAI4_ALLSI/520-545  AC A0A1U8DAI4.1
#=GS A0A0D9RL63_CHLSB/551-576  AC A0A0D9RL63.1
#=GS G3IBL5_CRIGR/374-399      AC G3IBL5.1
#=GS OPTN_CHICK/530-555        AC Q90Z16.1
#=GS A9QT41_PIG/393-418        AC A9QT41.1
#=GS A0A0G2JT32_RAT/483-508    AC A0A0G2JT32.1
#=GS A0A1U7TFB0_TARSY/393-418  AC A0A1U7TFB0.1
#=GS H2N2R3_ORYLA/532-557      AC H2N2R3.1
#=GS A0A2K5LJN5_CERAT/393-418  AC A0A2K5LJN5.1
#=GS A0A091V7N1_NIPNI/505-529  AC A0A091V7N1.1
#=GS A0A0P7UM68_9TELE/550-575  AC A0A0P7UM68.1
#=GS OPTN_MACMU/545-570        AC Q861Q8.1
#=GS A0A2K5K9R9_COLAP/545-570  AC A0A2K5K9R9.1
#=GS A0A091HVK6_CALAN/515-539  AC A0A091HVK6.1
#=GS A0A1S3F1X8_DIPOR/548-573  AC A0A1S3F1X8.1
#=GS L8GHL1_ACACA/1134-1156    AC L8GHL1.1
#=GS I3K179_ORENI/495-520      AC I3K179.1
#=GS W5NAA1_LEPOC/627-652      AC W5NAA1.1
#=GS Q8VC91_MOUSE/385-410      AC Q8VC91.1
#=GS A0A1A6H1X9_NEOLE/513-538  AC A0A1A6H1X9.1
#=GS A0A091D930_FUKDA/354-379  AC A0A091D930.1
#=GS G3TTB2_LOXAF/393-418      AC G3TTB2.1
#=GS A0A1L8GZE4_XENLA/545-569  AC A0A1L8GZE4.1
#=GS I3N9M0_ICTTR/479-504      AC I3N9M0.2
#=GS A0A0P7XFN4_9TELE/472-497  AC A0A0P7XFN4.1
#=GS A0A1U7RGP0_MESAU/385-410  AC A0A1U7RGP0.1
#=GS J9P891_CANLF/393-418      AC J9P891.1
#=GS G3QQD5_GORGO/461-486      AC G3QQD5.1
#=GS NEMO_MOUSE/386-411        AC O88522.2
#=GS H2N9S6_PONAB/506-531      AC H2N9S6.1
#=GS E2RBP8_CANLF/556-581      AC E2RBP8.2
#=GS A0A2I4CLD8_9TELE/568-593  AC A0A2I4CLD8.1
#=GS H0VAE0_CAVPO/550-575      AC H0VAE0.1
#=GS G3VKD7_SARHA/400-425      AC G3VKD7.1
#=GS A0A091S452_NESNO/507-532  AC A0A091S452.1
#=GS A0A0A0ABW7_CHAVO/527-551  AC A0A0A0ABW7.1
#=GS F6UET8_ORNAN/549-574      AC F6UET8.2
#=GS OPTN_RAT/559-584          AC Q8R5M4.3
#=GS Q3ZC32_BOVIN/547-572      AC Q3ZC32.1
#=GS H2RZL2_TAKRU/549-574      AC H2RZL2.1
#=GS F6WK94_MACMU/583-608      AC F6WK94.2
#=GS A0A1U8CS87_MESAU/386-411  AC A0A1U8CS87.1
#=GS A0A2I2YLQ3_GORGO/374-399  AC A0A2I2YLQ3.1
#=GS U3JGS6_FICAL/530-555      AC U3JGS6.1
#=GS A0A093K0J4_STRCA/417-441  AC A0A093K0J4.1
#=GS A0A2I4BVH6_9TELE/566-591  AC A0A2I4BVH6.1
#=GS A0A1U7S552_ALLSI/508-533  AC A0A1U7S552.1
#=GS F7GMH1_MACMU/461-486      AC F7GMH1.1
#=GS L5L5S8_PTEAL/368-393      AC L5L5S8.1
#=GS W4XXF6_STRPU/636-660      AC W4XXF6.1
#=GS G1P540_MYOLU/549-573      AC G1P540.1
#=GS A0A0G2K3Z1_RAT/396-421    AC A0A0G2K3Z1.1
#=GS A0A2K5NAV8_CERAT/545-570  AC A0A2K5NAV8.1
#=GS G3PIJ0_GASAC/544-569      AC G3PIJ0.1
#=GS F7GML8_MACMU/294-319      AC F7GML8.2
#=GS B0KWU0_CALJA/393-418      AC B0KWU0.1
#=GS A0A091DTV9_FUKDA/597-622  AC A0A091DTV9.1
#=GS A0A1S3GQ65_DIPOR/383-408  AC A0A1S3GQ65.1
#=GS H3CN64_TETNG/499-524      AC H3CN64.1
#=GS S7Q9Q8_MYOBR/375-400      AC S7Q9Q8.1
#=GS A0A2C9LNT8_BIOGL/539-563  AC A0A2C9LNT8.1
#=GS A0A093Q2G1_9PASS/520-545  AC A0A093Q2G1.1
#=GS F6T3V5_CALJA/294-319      AC F6T3V5.1
#=GS A0A287DAI3_ICTTR/393-418  AC A0A287DAI3.1
#=GS A0A1U8K2T8_GOSHI/45-66    AC A0A1U8K2T8.1
#=GS M3XPH7_MUSPF/560-585      AC M3XPH7.1
#=GS A0A2I3TAI0_PANTR/393-418  AC A0A2I3TAI0.1
#=GS F6UWH6_HORSE/559-584      AC F6UWH6.1
#=GS G5BFL6_HETGA/313-338      AC G5BFL6.1
#=GS K7GC11_PELSI/534-559      AC K7GC11.1
#=GS F6Z6G3_XENTR/506-530      AC F6Z6G3.1
#=GS A0A1S3GS96_DIPOR/391-416  AC A0A1S3GS96.1
#=GS H2L9T8_ORYLA/519-544      AC H2L9T8.1
#=GS A1L2U3_XENLA/501-525      AC A1L2U3.1
#=GS M3YEK4_MUSPF/386-411      AC M3YEK4.1
#=GS H2RI27_PANTR/392-417      AC H2RI27.2
#=GS H3A533_LATCH/370-395      AC H3A533.1
#=GS A0A099Z945_TINGU/259-283  AC A0A099Z945.1
#=GS W5LAG8_ASTMX/544-569      AC W5LAG8.1
#=GS F1Q438_CANLF/406-431      AC F1Q438.2
#=GS A0A2I4BVK8_9TELE/550-575  AC A0A2I4BVK8.1
#=GS OPTN_DANRE/491-516        AC Q5RI56.2
#=GS G3Q620_GASAC/532-557      AC G3Q620.1
#=GS A0A091UFN0_PHORB/506-530  AC A0A091UFN0.1
#=GS A0A0Q3PMM7_AMAAE/531-556  AC A0A0Q3PMM7.1
#=GS D2I3B5_AILME/397-422      AC D2I3B5.1
#=GS A0A226PDE8_COLVI/539-564  AC A0A226PDE8.1
#=GS A0A2I3MF75_PAPAN/495-520  AC A0A2I3MF75.1
#=GS F6UWD8_HORSE/548-573      AC F6UWD8.1
#=GS M3X2Y1_FELCA/393-418      AC M3X2Y1.2
#=GS F7HCS8_MACMU/495-520      AC F7HCS8.1
#=GS B5X3H2_SALSA/545-570      AC B5X3H2.1
#=GS A0A151NPP5_ALLMI/520-545  AC A0A151NPP5.1
#=GS G1MZZ3_MELGA/532-557      AC G1MZZ3.1
#=GS G8JLS4_RAT/557-582        AC G8JLS4.1
#=GS A0A2I3SEM3_PANTR/545-570  AC A0A2I3SEM3.1
#=GS A0A2I3H5E5_NOMLE/551-576  AC A0A2I3H5E5.1
#=GS A0A2I4BVJ1_9TELE/557-582  AC A0A2I4BVJ1.1
#=GS A0A091GM26_BUCRH/523-548  AC A0A091GM26.1
#=GS G3UCW2_LOXAF/562-587      AC G3UCW2.1
#=GS A0A1A6HPM0_NEOLE/386-411  AC A0A1A6HPM0.1
#=GS F7I7M0_CALJA/551-576      AC F7I7M0.1
#=GS G3RVA2_GORGO/393-418      AC G3RVA2.2
#=GS F7GWR3_MACMU/393-418      AC F7GWR3.1
#=GS A0A1S3QBY8_SALSA/204-229  AC A0A1S3QBY8.1
#=GS A0A287D0D9_ICTTR/466-491  AC A0A287D0D9.1
#=GS A0A087Y6I8_POEFO/498-523  AC A0A087Y6I8.2
#=GS A0A1S2ZUB9_ERIEU/550-575  AC A0A1S2ZUB9.1
#=GS H2RZL4_TAKRU/363-388      AC H2RZL4.1
#=GS G3Q622_GASAC/500-525      AC G3Q622.1
#=GS F7DZC7_ORNAN/400-425      AC F7DZC7.1
#=GS A0A218VA29_9PASE/529-554  AC A0A218VA29.1
#=GS A0A2I3RXW1_PANTR/501-526  AC A0A2I3RXW1.1
#=GS H0YVJ9_TAEGU/519-544      AC H0YVJ9.1
#=GS A0A093NZT9_PYGAD/506-530  AC A0A093NZT9.1
#=GS A0A151MPX7_ALLMI/516-541  AC A0A151MPX7.1
#=GS H2TNH3_TAKRU/536-561      AC H2TNH3.1
#=GS A0A2G9RG32_LITCT/44-69    AC A0A2G9RG32.1
#=GS A5WUQ0_DANRE/491-516      AC A5WUQ0.1
#=GS L5L0Z9_PTEAL/548-573      AC L5L0Z9.1
#=GS H3A532_LATCH/409-434      AC H3A532.1
#=GS A0A0G2JUB3_RAT/559-584    AC A0A0G2JUB3.1
#=GS S9XNV7_CAMFR/185-210      AC S9XNV7.1
#=GS G1STZ8_RABIT/394-419      AC G1STZ8.1
#=GS A0A1U8D091_ALLSI/530-555  AC A0A1U8D091.1
#=GS G1KMI1_ANOCA/369-394      AC G1KMI1.1
#=GS A0A087X1B1_HUMAN/392-417  AC A0A087X1B1.1
#=GS A0A091F0H7_CORBR/494-518  AC A0A091F0H7.1
#=GS A0A1U7USZ3_TARSY/546-571  AC A0A1U7USZ3.1
#=GS G3WPC5_SARHA/348-373      AC G3WPC5.1
#=GS K7FYA9_PELSI/559-584      AC K7FYA9.1
#=GS A0A2K5K9S8_COLAP/495-520  AC A0A2K5K9S8.1
#=GS A0A1S3JF70_LINUN/841-865  AC A0A1S3JF70.1
#=GS F1M9C4_RAT/621-646        AC F1M9C4.2
#=GS F1QHG7_DANRE/576-601      AC F1QHG7.1
#=GS Q7TSS3_MOUSE/404-429      AC Q7TSS3.1
#=GS A0A091K0C2_COLST/501-525  AC A0A091K0C2.1
#=GS A0A1U7T5K9_TARSY/294-319  AC A0A1U7T5K9.1
#=GS I3MGM9_ICTTR/405-430      AC I3MGM9.2
#=GS E9Q2Y3_MOUSE/398-423      AC E9Q2Y3.1
#=GS K7GBZ3_PELSI/527-552      AC K7GBZ3.1
#=GS OPTN_PIG/548-573          AC Q7YS99.1
#=GS A0A1S3AP33_ERIEU/519-544  AC A0A1S3AP33.1
#=GS A0A091QA59_LEPDC/505-529  AC A0A091QA59.1
#=GS A5WUP9_DANRE/288-313      AC A5WUP9.1
#=GS G1RNU9_NOMLE/501-526      AC G1RNU9.2
#=GS A0A091R889_MERNU/507-532  AC A0A091R889.1
#=GS A0A2I0MHD3_COLLI/512-536  AC A0A2I0MHD3.1
#=GS A0A1S3SG67_SALSA/538-563  AC A0A1S3SG67.1
#=GS C3YPU4_BRAFL/847-871      AC C3YPU4.1
#=GS F1QHM5_DANRE/560-585      AC F1QHM5.1
#=GS A0A087YE77_POEFO/557-582  AC A0A087YE77.2
#=GS G3RQC2_GORGO/342-367      AC G3RQC2.2
#=GS NEMO_RAT/386-411          AC Q6TMG5.1
#=GS A0A0D2V7B6_GOSRA/45-66    AC A0A0D2V7B6.1
#=GS M3ZQ85_XIPMA/557-582      AC M3ZQ85.1
#=GS A0A0P7UL25_9TELE/488-513  AC A0A0P7UL25.1
#=GS H2TNH4_TAKRU/498-523      AC H2TNH4.1
#=GS I3IVM4_ORENI/571-596      AC I3IVM4.1
#=GS H2ZSA1_LATCH/132-157      AC H2ZSA1.1
#=GS A0A1U7UIE5_TARSY/545-570  AC A0A1U7UIE5.1
#=GS A0A1U8KRP5_GOSHI/45-66    AC A0A1U8KRP5.1
#=GS W5LEZ0_ASTMX/565-590      AC W5LEZ0.1
#=GS A0A1V4K0E9_PATFA/576-601  AC A0A1V4K0E9.1
#=GS A0A093DP72_9AVES/257-282  AC A0A093DP72.1
#=GS A0A091IVP6_EGRGA/497-522  AC A0A091IVP6.1
#=GS U3IAG4_ANAPL/551-575      AC U3IAG4.1
#=GS A0A2I3SZL4_PANTR/461-486  AC A0A2I3SZL4.1
#=GS A0A087WUW6_HUMAN/386-411  AC A0A087WUW6.1
#=GS F6TK31_HORSE/392-417      AC F6TK31.1
#=GS A0A1S3WVG6_ERIEU/518-543  AC A0A1S3WVG6.1
#=GS W5P590_SHEEP/547-572      AC W5P590.1
#=GS OPTN_MOUSE/558-583        AC Q8K3K8.1
#=GS H0WGU6_OTOGA/555-580      AC H0WGU6.1
#=GS H2PXA1_PONAB/461-486      AC H2PXA1.2
#=GS G3RFJ6_GORGO/501-526      AC G3RFJ6.2
#=GS S7NAS1_MYOBR/548-573      AC S7NAS1.1
#=GS M0RAB4_RAT/329-354        AC M0RAB4.2
#=GS K1Q2D0_CRAGI/657-681      AC K1Q2D0.1
#=GS A0A087VLF1_BALRE/500-524  AC A0A087VLF1.1
#=GS G7PED9_MACFA/551-576      AC G7PED9.1
#=GS W5NAA3_LEPOC/583-608      AC W5NAA3.1
#=GS A0A091RD94_9GRUI/502-526  AC A0A091RD94.1
#=GS A0A2I3RH48_PANTR/348-373  AC A0A2I3RH48.1
#=GS F6R1Z3_MONDO/618-643      AC F6R1Z3.2
#=GS A0A2I2ZAB4_GORGO/369-394  AC A0A2I2ZAB4.1
#=GS H0WAZ4_CAVPO/390-415      AC H0WAZ4.2
#=GS F7ADE2_MONDO/423-448      AC F7ADE2.2
#=GS NEMO_HUMAN/393-418        AC Q9Y6K9.2
#=GS NEMO_HUMAN/393-418        DR PDB; 5AAY A; 393-418;
#=GS NEMO_HUMAN/393-418        DR PDB; 2JVY A; 3-27;
#=GS NEMO_HUMAN/393-418        DR PDB; 2JVX A; 3-27;
#=GS K7CAG5_PANTR/551-576      AC K7CAG5.1
#=GS A0A1S3F0L2_DIPOR/547-572  AC A0A1S3F0L2.1
#=GS A0A087RE44_APTFO/509-533  AC A0A087RE44.1
#=GS K7GQV6_PIG/342-367        AC K7GQV6.2
#=GS A0A093GMZ7_TYTAL/502-526  AC A0A093GMZ7.1
#=GS A0A2I2ZQA1_GORGO/551-576  AC A0A2I2ZQA1.1
#=GS G1SRQ8_RABIT/459-484      AC G1SRQ8.2
#=GS A0A091KNN6_9GRUI/258-282  AC A0A091KNN6.1
#=GS A0A1V4K088_PATFA/577-602  AC A0A1V4K088.1
#=GS A0A1U8D0B9_ALLSI/540-565  AC A0A1U8D0B9.1
#=GS F7ASB3_CALJA/398-423      AC F7ASB3.1
#=GS A0A1S3GRC3_DIPOR/384-409  AC A0A1S3GRC3.1
#=GS F7AMM1_CALJA/403-428      AC F7AMM1.1
#=GS A0A2I3SHW7_PANTR/375-400  AC A0A2I3SHW7.1
#=GS V8NHC0_OPHHA/440-465      AC V8NHC0.1
#=GS NEMO_BOVIN/393-418        AC Q95KU9.1
#=GS A0A096P3F9_PAPAN/551-576  AC A0A096P3F9.2
#=GS G3TB30_LOXAF/548-573      AC G3TB30.1
#=GS A0A1S3GPS8_DIPOR/340-365  AC A0A1S3GPS8.1
#=GS M4A2F1_XIPMA/499-524      AC M4A2F1.1
#=GS A0A1U7RXW7_ALLSI/181-206  AC A0A1U7RXW7.1
#=GS A0A1S3GPL5_DIPOR/390-415  AC A0A1S3GPL5.1
#=GS H2RZL3_TAKRU/364-389      AC H2RZL3.1
#=GS A0A2I2YCG4_GORGO/391-416  AC A0A2I2YCG4.1
#=GS A0A2K5K5P6_COLAP/343-368  AC A0A2K5K5P6.1
#=GS H0XPP3_OTOGA/394-419      AC H0XPP3.1
#=GS W5P1P1_SHEEP/387-412      AC W5P1P1.1
#=GS G3GVQ4_CRIGR/597-622      AC G3GVQ4.1
#=GS A0A2I3RAD7_PANTR/369-394  AC A0A2I3RAD7.1
#=GS A0A2I3TJY3_PANTR/294-319  AC A0A2I3TJY3.1
#=GS H2RZL1_TAKRU/565-590      AC H2RZL1.1
#=GS A0A1U7QL97_MESAU/487-512  AC A0A1U7QL97.1
#=GS L8YA06_TUPCH/394-419      AC L8YA06.1
#=GS A0A1S3MIN7_SALSA/549-574  AC A0A1S3MIN7.1
#=GS G1M4E5_AILME/565-590      AC G1M4E5.1
#=GS K7GSZ7_PIG/425-450        AC K7GSZ7.1
#=GS M3W172_FELCA/548-573      AC M3W172.2
#=GS A0A2D0T5F4_ICTPU/524-549  AC A0A2D0T5F4.1
#=GS A0A087X0G7_HUMAN/385-410  AC A0A087X0G7.1
#=GS G5BE21_HETGA/548-573      AC G5BE21.1
#=GS W5NFE0_LEPOC/556-581      AC W5NFE0.1
#=GS A0A2K5LJP9_CERAT/294-319  AC A0A2K5LJP9.1
#=GS OPTN_PONAB/501-526        AC Q5R923.1
#=GS G1QA20_MYOLU/399-424      AC G1QA20.1
#=GS OPTN_HUMAN/551-576        AC Q96CV9.3
#=GS OPTN_HUMAN/551-576        DR PDB; 2LO4 A; 25-50;
#=GS OPTN_HUMAN/551-576        DR PDB; 5AAZ A; 494-519;
#=GS A0A093ID25_FULGA/505-529  AC A0A093ID25.1
#=GS W5UL35_ICTPU/542-567      AC W5UL35.1
#=GS A0A093Q9X9_PHACA/503-527  AC A0A093Q9X9.1
#=GS G1K9C2_ANOCA/522-547      AC G1K9C2.2
#=GS M7BNP1_CHEMY/520-545      AC M7BNP1.1
#=GS M7AGA5_CHEMY/452-477      AC M7AGA5.1
F7DVK0_XENTR/481-506                 ...PDFSCPKCFYKAPDMDTLQIHVMDCI.
A0A2I2YWZ1_GORGO/294-319             ...PDFCCPKCQYQAPDMDTLQIHVMECI.
A0A1U8DAI4_ALLSI/520-545             ...PMHSCPKCGEILPDIDTLQIHVMDCI.
A0A0D9RL63_CHLSB/551-576             ...PIHSCPKCGEVLPDIDTLQIHVMDCI.
G3IBL5_CRIGR/374-399                 ...PDFCCPKCQYQAPDMDTLQIHVMECI.
OPTN_CHICK/530-555                   ..s-IYSCPKCEEILPDLDTLQIHVMDCI.
A9QT41_PIG/393-418                   ...PNFCCPKCQYQAPDMDTLQIHVMECI.
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A0A093ID25_FULGA/505-529             ..m--YSCPKCEEILPDLDTLQIHVMDCI.
W5UL35_ICTPU/542-567                 ...PEYQCPKCQYNAPDMDTLQIHVMDCI.
A0A093Q9X9_PHACA/503-527             ..m--YSCPKCEEILPDLDTLQIHVMDCI.
G1K9C2_ANOCA/522-547                 ...PAQSCPKCGMILPDIDTLQIHVMDCI.
M7BNP1_CHEMY/520-545                 ...PVHSCPKCGEILPDMDTLQIHVMDCI.
M7AGA5_CHEMY/452-477                 ...PDFCCPKCQYQAPDMDTLQIHVMDCI.
#=GC SS_cons                         ...-SEE-TTTTTCESSCHHHHHHHHCCT.
#=GC seq_cons                        ...P.asCPKCp.hhPDhDTLQIHVMDCI.
//
DBGET integrated database retrieval system