KEGG   Panthera pardus (leopard): 109254113
Entry
109254113         CDS       T06062                                 
Symbol
TYK2
Name
(RefSeq) non-receptor tyrosine-protein kinase TYK2 isoform X1
  KO
K11219  non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad04217  Necroptosis
ppad04380  Osteoclast differentiation
ppad04620  Toll-like receptor signaling pathway
ppad04621  NOD-like receptor signaling pathway
ppad04630  JAK-STAT signaling pathway
ppad04658  Th1 and Th2 cell differentiation
ppad04659  Th17 cell differentiation
ppad05145  Toxoplasmosis
ppad05160  Hepatitis C
ppad05161  Hepatitis B
ppad05162  Measles
ppad05164  Influenza A
ppad05165  Human papillomavirus infection
ppad05167  Kaposi sarcoma-associated herpesvirus infection
ppad05168  Herpes simplex virus 1 infection
ppad05169  Epstein-Barr virus infection
ppad05171  Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    109254113 (TYK2)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    109254113 (TYK2)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    109254113 (TYK2)
   04621 NOD-like receptor signaling pathway
    109254113 (TYK2)
   04658 Th1 and Th2 cell differentiation
    109254113 (TYK2)
   04659 Th17 cell differentiation
    109254113 (TYK2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    109254113 (TYK2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    109254113 (TYK2)
   05160 Hepatitis C
    109254113 (TYK2)
   05171 Coronavirus disease - COVID-19
    109254113 (TYK2)
   05164 Influenza A
    109254113 (TYK2)
   05162 Measles
    109254113 (TYK2)
   05168 Herpes simplex virus 1 infection
    109254113 (TYK2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109254113 (TYK2)
   05169 Epstein-Barr virus infection
    109254113 (TYK2)
   05165 Human papillomavirus infection
    109254113 (TYK2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    109254113 (TYK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ppad01001]
    109254113 (TYK2)
Enzymes [BR:ppad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     109254113 (TYK2)
Protein kinases [BR:ppad01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   109254113 (TYK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 Kdo Kinase-like FERM_C_FAK1 RIO1 ABC1
Other DBs
NCBI-GeneID: 109254113
NCBI-ProteinID: XP_019283298
Ensembl: ENSPPRG00000012402
UniProt: A0A9V1EK24
Position
Unknown
AA seq 1181 aa
MPLCRWGATTRDSRPDGDEAQPMVSRGGLKVLLHWAGPDGGDPWVTFSEATLTAEEVCIH
IAHKVGITPSCLNLFALFDAQAQVWLPPNHILEVSRDMNLTLYFRMRFYFRNWHSMNPQE
PAVYRCGPTRAKSSSEQAEQGVQLLDPASFEYLFEQGKHEFVNDVAPLWELSSEEEIHHF
KNESLGMAFLHLCHLALCHGIPLEKVAKKISFKDCIPRSFRLQLRRHNALTRLRLRRLFR
RFVRAFQPGHVSQPVIMVKYLATLEQLAPRFGTERVLVCRLEEQARAVGDPCYVQDGGQS
PPEPGPELAPGPPTHEVLVTGTGGIRWRPVQAEGPSGDGCSRNPRAGPSGKKSKAQEVGN
QPVDRPQEAPWAYFCDFQDITHVVLKERHVSIHCQDKCLELTLPSRAVALSLVSLVDGYF
RLTADSSHYLCREVAPPRLVMSIRDGIHGPLLEPFVLAKLRPEDGLYLIHWSTSHLNRLI
LTVAQRDQAPGGQQLHLRKFPIELRAGSFELEGWDRSFPSVRELRTALQGCSLRVGDDCF
SLRRCCLPRPGELSNLIIMRGSRASPGPLNLSQLSFHRVCQDDITQLSHLGQGTRTNVYE
GILRVGERGPKEGTADGGDPPTPSGDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVS
HVHLAFVHGVCVHGSENIMVTEYVEHGPLDVWLRRERGHVPVAWKVAVAQQLASALSYLE
DKSLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWTAPECLSG
GASTLTTAADKWGFGVTLLEICFDGEAPLQGRGPSEKECFYQKQHQLPQPSCPELATLTS
QCLTYEPAQRPSFRTILRDLTQLQPQNLADILAVNPDSPASDPTVFHKRYLKKIRDLGEG
HFGKVSLYCYDPTNDGTGEMVAVKALKAGGGPQLRTGWRREIDILRTLYHKHIVKYKGCC
EDQGEKSVQLVMEYVPLGSLRDYLPRHNVGLAQLLLFAQQICEGMAYLHAQHYVHRDLAA
RNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWS
FGVTMYELLTYCDSSQSPPSKFIELIGLTQGQMTVLRLTELLERGERLPRPEKCPCEIYL
LMKNCWEAEASFRPTFQNLIPILKTVQEKYQGQAASVFNVC
NT seq 3546 nt   +upstreamnt  +downstreamnt
atgcctctgtgccgttggggtgccaccaccagggacagcaggcctgatggggatgaggct
cagcccatggtctccaggggaggcctaaaggtccttctgcactgggctggccctgatggc
ggggacccctgggtcaccttcagcgaggccacactgaccgcagaggaggtctgcatccac
atcgcacacaaagtcggcatcactccatcctgcctcaatctcttcgccctctttgatgcc
caggcccaggtgtggctgcccccaaaccacatcttggaggtctccagagacatgaacctg
acattgtacttccgcatgaggttttatttccggaactggcacagcatgaatcctcaggag
ccggccgtgtaccgctgtgggcccaccagggccaagtcttcctcggaacaggcagagcag
ggcgtgcaactcctggacccagcctcctttgagtacctctttgagcagggcaagcacgag
tttgtgaatgatgtggcaccactgtgggagctgtcgagcgaggaggagatccaccatttt
aagaacgagagcctgggcatggcctttctgcacctctgccacctcgccctttgccatggt
atccccctggagaaggtggccaagaagatcagcttcaaggactgcatcccgcgctccttc
cggctgcagctccggcggcacaacgcgttaacacggctgcgcctacggagactcttccgc
aggtttgtgcgggccttccagccgggccacgtctcccagccggtcatcatggtcaagtac
ctggccacgctggagcagctggcaccccgcttcggcacggagcgcgtgctcgtgtgccgg
ctggaggagcaggcccgggccgtgggggacccctgctacgtccaggacgggggccagtcc
cccccggagcctgggcctgaattggcccccggaccccctactcatgaggtgctggtgaca
ggcacgggtggcatccggtggcggccagtccaggcagagggtcccagtggcgatggttgc
agcaggaacccccgtgctggcccatcagggaagaaaagcaaggcccaggaggtgggcaac
cagccagtggacaggcctcaggaagcgccgtgggcctacttctgtgacttccaggacatc
acccacgttgtgctgaaagagcgccacgtcagcatccactgtcaggacaagtgcctggag
ctcaccctgccttcccgggctgtggccctgtccttggtgtcgctggtggacggctatttc
cgcctgacggccgactcgagccactacctgtgccgggaggtggcccctccgcggctggtg
atgagcatccgggatggcatccacgggcccttgctggagccattcgtgctggccaagctg
cggcccgaagatggcctctacctcatccactggagcaccagccacctcaaccgtctcatc
ctcacggtggcccagcgtgaccaggcacctggcgggcagcagctgcacctccgtaaattc
cccattgagctgcgggccgggagcttcgagctggagggctgggaccgctccttcccgagc
gtgcgggagctgcgcaccgccctgcagggctgctcgctgcgggtcggggacgactgtttc
tccctgcgccgctgctgcctgccacggcccggagagctctccaacctcatcatcatgcgt
gggtctcgggccagccctgggccactcaacctcagccagctcagcttccaccgcgtctgc
caggatgacattactcagctgtctcacttgggccaaggcacgaggaccaatgtgtatgag
ggcatcttacgggtgggggaaagaggccccaaggagggcacggcagatggtggggacccc
cccacgcccagtggggaccgtggacaggagctacgagtggtactcaaggtgctggatccc
agtcaccacgacatcgccctggccttctacgagacagccagcctcatgagccaggtctcc
cacgtgcacctggcctttgtgcacggcgtctgtgtgcacggctctgagaacatcatggtg
acagagtacgtggagcacggacccctggatgtgtggctgcggcgggagaggggccacgtg
cctgtggcctggaaggtggcagtggcccagcagctggccagcgctctcagctacctggaa
gacaagagcctggttcatggtaatgtgtgtggccggaatatcctgctggcacggctggga
ctggcggagggcaccagcccctttatcaagctgagcgatcccggtgtgggcctgggtgcc
ctttccagggaggagcgggtagagaggatcccctggacagcccccgagtgcctgtcaggt
ggggccagcaccctaaccactgcagctgacaaatggggctttggtgtcaccctcctggag
atctgcttcgacggggaggcccctctgcagggccgcggcccttccgagaaagagtgcttc
taccagaagcagcaccagcttcctcagccctcatgcccggagctggccacactcaccagc
cagtgcctgacctatgaaccagctcagcggccctccttccgcaccatcctgcgtgacctc
actcagctgcagccccagaatcttgctgacatcttggctgtgaaccccgactcgcctgcg
tcagaccccaccgttttccacaagcgctatttgaaaaagatccgggatctgggcgagggt
catttcggcaaggtcagtctgtattgctacgacccgactaacgacggcaccggcgagatg
gtggctgtgaaggccctcaaggcgggcgggggcccccagctccgcactggctggcggcgg
gagatcgacatcctgcgcacgctctaccacaagcacatcgtcaaatacaagggatgctgt
gaggaccaaggagagaagtcggtgcagctggttatggagtacgtgcctctgggcagcctc
cgggactaccttccccggcacaacgtcggactggcccaactgctactcttcgcccagcag
atctgtgagggcatggcctaccttcatgcacagcactacgtccaccgagacctggctgcc
cgcaacgtgctgctggacaacgacaggctggtcaaaatcggggactttggcctagccaag
gctgtgcctgaaggccatgagtactaccgcgtgcgcgaagatggggacagccccgtattc
tggtatgctccagagtgcctgaaggagtgtaagttctactatgcatctgacgtctggtcc
ttcggggtcaccatgtatgagctgctgacctactgtgactccagccagagccccccttcg
aaattcatcgagctcataggcctcacccaagggcagatgacggtgctgaggctcactgag
ctgctggaacgaggggagaggctgccgcggccagagaaatgcccttgcgagatctacctc
ctcatgaagaactgctgggaggcagaggcctcattccgccccactttccagaacctcatc
cccattctcaagacggtccaggagaaataccaaggccaggctgcctcagtgttcaatgtg
tgctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (17)   
   KEGG PATHWAY (17)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (10)   
   Pfam (10)   
All databases (40)   

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