KEGG   Panthera pardus (leopard): 109256394
Entry
109256394         CDS       T06062                                 
Symbol
PDHA1
Name
(RefSeq) pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
  KO
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad00010  Glycolysis / Gluconeogenesis
ppad00020  Citrate cycle (TCA cycle)
ppad00620  Pyruvate metabolism
ppad00785  Lipoic acid metabolism
ppad01100  Metabolic pathways
ppad01200  Carbon metabolism
ppad01210  2-Oxocarboxylic acid metabolism
ppad04066  HIF-1 signaling pathway
ppad04922  Glucagon signaling pathway
ppad05230  Central carbon metabolism in cancer
ppad05415  Diabetic cardiomyopathy
Module
ppad_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    109256394 (PDHA1)
   00020 Citrate cycle (TCA cycle)
    109256394 (PDHA1)
   00620 Pyruvate metabolism
    109256394 (PDHA1)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    109256394 (PDHA1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    109256394 (PDHA1)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    109256394 (PDHA1)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    109256394 (PDHA1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    109256394 (PDHA1)
Enzymes [BR:ppad01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.1  pyruvate dehydrogenase (acetyl-transferring)
     109256394 (PDHA1)
SSDB
Motif
Pfam: E1_dh DXP_synthase_N TPP_enzyme_C
Other DBs
NCBI-GeneID: 109256394
NCBI-ProteinID: XP_019287205
Ensembl: ENSPPRG00000008782
UniProt: A0A9V1ERR1
Position
Unknown
AA seq 390 aa
MRKMLAAVSRVLSGVAQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
HGFTFTRGLSVREILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
LEELGYHIYSSDPPFEVRGANQWIKFKSIS
NT seq 1173 nt   +upstreamnt  +downstreamnt
atgaggaaaatgctcgcagctgtctcccgcgtgttgtcgggcgtcgcccagaagccggca
agcagagtgctggtggcatcccgtaattttgcaaatgatgctacatttgaaattaagaaa
tgtgatcttcaccgactggaagagggccctcctgtcaccacggtactcaccagggaggat
gggctcaaatactataggatgatgcagactgttcgccgaatggaattaaaggcagatcag
ctgtataaacagaaaattattcgtggtttttgtcacttgtgtgatggtcaggaagcttgt
tgtgtgggcctggaggccggcataaatcccacagaccatcttatcacagcctatcgggct
catggcttcacctttactcgtggactttctgtccgagaaattcttgcagagcttacagga
cgaagaggaggttgcgctaaagggaaaggcggatcgatgcatatgtatgccaaaaacttc
tacgggggcaacggcatcgtcggagctcaggtgcccctgggagcagggattgctctggcc
tgtaagtataacggaaaggatgaggtctgtttgactttatatggcgatggtgctgctaac
caaggtcagatattcgaagcttacaatatggcagctttgtggaaattgccatgtattttc
atctgtgaaaataaccgctatggaatgggaacatctgttgagagagcagcggccagcacg
gattactacaagagaggtgacttcattcctgggctgagggtagatggaatggatatcctg
tgtgtccgggaggcgacgaggtttgcagccgcctactgtagatctggaaaggggcccata
ctgatggagctacagacttaccgctaccacggacatagcatgagtgaccctggtgtcagt
taccgtacacgagaggagattcaggaagtaagaagtaagagtgaccctattatgcttctc
aaggatagaatggtgaacagcaacctggccagtgttgaagaattaaaggaaattgatgtt
gaagtgaggaaagaaattgaggatgctgcccagtttgccaccgctgatcctgaaccgcct
ttggaagaactaggctatcacatttacagcagcgacccaccttttgaagttcggggtgca
aatcagtggatcaagtttaagtccatcagttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (12)   
   KEGG PATHWAY (11)   
   KEGG MODULE (1)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (3)   
   Pfam (3)   
All databases (41)   

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