KEGG   Panthera pardus (leopard): 109268745
Entry
109268745         CDS       T06062                                 
Symbol
KRAS
Name
(RefSeq) GTPase KRas isoform X1
  KO
K07827  GTPase KRas
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad01521  EGFR tyrosine kinase inhibitor resistance
ppad01522  Endocrine resistance
ppad04010  MAPK signaling pathway
ppad04012  ErbB signaling pathway
ppad04014  Ras signaling pathway
ppad04015  Rap1 signaling pathway
ppad04062  Chemokine signaling pathway
ppad04068  FoxO signaling pathway
ppad04071  Sphingolipid signaling pathway
ppad04072  Phospholipase D signaling pathway
ppad04137  Mitophagy - animal
ppad04140  Autophagy - animal
ppad04150  mTOR signaling pathway
ppad04151  PI3K-Akt signaling pathway
ppad04210  Apoptosis
ppad04211  Longevity regulating pathway
ppad04213  Longevity regulating pathway - multiple species
ppad04218  Cellular senescence
ppad04360  Axon guidance
ppad04370  VEGF signaling pathway
ppad04371  Apelin signaling pathway
ppad04540  Gap junction
ppad04550  Signaling pathways regulating pluripotency of stem cells
ppad04625  C-type lectin receptor signaling pathway
ppad04650  Natural killer cell mediated cytotoxicity
ppad04660  T cell receptor signaling pathway
ppad04662  B cell receptor signaling pathway
ppad04664  Fc epsilon RI signaling pathway
ppad04714  Thermogenesis
ppad04720  Long-term potentiation
ppad04722  Neurotrophin signaling pathway
ppad04725  Cholinergic synapse
ppad04726  Serotonergic synapse
ppad04730  Long-term depression
ppad04810  Regulation of actin cytoskeleton
ppad04910  Insulin signaling pathway
ppad04912  GnRH signaling pathway
ppad04914  Progesterone-mediated oocyte maturation
ppad04915  Estrogen signaling pathway
ppad04916  Melanogenesis
ppad04917  Prolactin signaling pathway
ppad04919  Thyroid hormone signaling pathway
ppad04921  Oxytocin signaling pathway
ppad04926  Relaxin signaling pathway
ppad04929  GnRH secretion
ppad04933  AGE-RAGE signaling pathway in diabetic complications
ppad04935  Growth hormone synthesis, secretion and action
ppad04960  Aldosterone-regulated sodium reabsorption
ppad05010  Alzheimer disease
ppad05022  Pathways of neurodegeneration - multiple diseases
ppad05034  Alcoholism
ppad05160  Hepatitis C
ppad05161  Hepatitis B
ppad05163  Human cytomegalovirus infection
ppad05165  Human papillomavirus infection
ppad05166  Human T-cell leukemia virus 1 infection
ppad05167  Kaposi sarcoma-associated herpesvirus infection
ppad05170  Human immunodeficiency virus 1 infection
ppad05200  Pathways in cancer
ppad05203  Viral carcinogenesis
ppad05205  Proteoglycans in cancer
ppad05206  MicroRNAs in cancer
ppad05207  Chemical carcinogenesis - receptor activation
ppad05208  Chemical carcinogenesis - reactive oxygen species
ppad05210  Colorectal cancer
ppad05211  Renal cell carcinoma
ppad05212  Pancreatic cancer
ppad05213  Endometrial cancer
ppad05214  Glioma
ppad05215  Prostate cancer
ppad05216  Thyroid cancer
ppad05218  Melanoma
ppad05219  Bladder cancer
ppad05220  Chronic myeloid leukemia
ppad05221  Acute myeloid leukemia
ppad05223  Non-small cell lung cancer
ppad05224  Breast cancer
ppad05225  Hepatocellular carcinoma
ppad05226  Gastric cancer
ppad05230  Central carbon metabolism in cancer
ppad05231  Choline metabolism in cancer
ppad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ppad05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    109268745 (KRAS)
   04012 ErbB signaling pathway
    109268745 (KRAS)
   04014 Ras signaling pathway
    109268745 (KRAS)
   04015 Rap1 signaling pathway
    109268745 (KRAS)
   04370 VEGF signaling pathway
    109268745 (KRAS)
   04371 Apelin signaling pathway
    109268745 (KRAS)
   04068 FoxO signaling pathway
    109268745 (KRAS)
   04072 Phospholipase D signaling pathway
    109268745 (KRAS)
   04071 Sphingolipid signaling pathway
    109268745 (KRAS)
   04151 PI3K-Akt signaling pathway
    109268745 (KRAS)
   04150 mTOR signaling pathway
    109268745 (KRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    109268745 (KRAS)
   04137 Mitophagy - animal
    109268745 (KRAS)
  09143 Cell growth and death
   04210 Apoptosis
    109268745 (KRAS)
   04218 Cellular senescence
    109268745 (KRAS)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    109268745 (KRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    109268745 (KRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109268745 (KRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    109268745 (KRAS)
   04650 Natural killer cell mediated cytotoxicity
    109268745 (KRAS)
   04660 T cell receptor signaling pathway
    109268745 (KRAS)
   04662 B cell receptor signaling pathway
    109268745 (KRAS)
   04664 Fc epsilon RI signaling pathway
    109268745 (KRAS)
   04062 Chemokine signaling pathway
    109268745 (KRAS)
  09152 Endocrine system
   04910 Insulin signaling pathway
    109268745 (KRAS)
   04929 GnRH secretion
    109268745 (KRAS)
   04912 GnRH signaling pathway
    109268745 (KRAS)
   04915 Estrogen signaling pathway
    109268745 (KRAS)
   04914 Progesterone-mediated oocyte maturation
    109268745 (KRAS)
   04917 Prolactin signaling pathway
    109268745 (KRAS)
   04921 Oxytocin signaling pathway
    109268745 (KRAS)
   04926 Relaxin signaling pathway
    109268745 (KRAS)
   04935 Growth hormone synthesis, secretion and action
    109268745 (KRAS)
   04919 Thyroid hormone signaling pathway
    109268745 (KRAS)
   04916 Melanogenesis
    109268745 (KRAS)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    109268745 (KRAS)
  09156 Nervous system
   04725 Cholinergic synapse
    109268745 (KRAS)
   04726 Serotonergic synapse
    109268745 (KRAS)
   04720 Long-term potentiation
    109268745 (KRAS)
   04730 Long-term depression
    109268745 (KRAS)
   04722 Neurotrophin signaling pathway
    109268745 (KRAS)
  09158 Development and regeneration
   04360 Axon guidance
    109268745 (KRAS)
  09149 Aging
   04211 Longevity regulating pathway
    109268745 (KRAS)
   04213 Longevity regulating pathway - multiple species
    109268745 (KRAS)
  09159 Environmental adaptation
   04714 Thermogenesis
    109268745 (KRAS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109268745 (KRAS)
   05206 MicroRNAs in cancer
    109268745 (KRAS)
   05205 Proteoglycans in cancer
    109268745 (KRAS)
   05207 Chemical carcinogenesis - receptor activation
    109268745 (KRAS)
   05208 Chemical carcinogenesis - reactive oxygen species
    109268745 (KRAS)
   05203 Viral carcinogenesis
    109268745 (KRAS)
   05230 Central carbon metabolism in cancer
    109268745 (KRAS)
   05231 Choline metabolism in cancer
    109268745 (KRAS)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109268745 (KRAS)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109268745 (KRAS)
   05212 Pancreatic cancer
    109268745 (KRAS)
   05225 Hepatocellular carcinoma
    109268745 (KRAS)
   05226 Gastric cancer
    109268745 (KRAS)
   05214 Glioma
    109268745 (KRAS)
   05216 Thyroid cancer
    109268745 (KRAS)
   05221 Acute myeloid leukemia
    109268745 (KRAS)
   05220 Chronic myeloid leukemia
    109268745 (KRAS)
   05218 Melanoma
    109268745 (KRAS)
   05211 Renal cell carcinoma
    109268745 (KRAS)
   05219 Bladder cancer
    109268745 (KRAS)
   05215 Prostate cancer
    109268745 (KRAS)
   05213 Endometrial cancer
    109268745 (KRAS)
   05224 Breast cancer
    109268745 (KRAS)
   05223 Non-small cell lung cancer
    109268745 (KRAS)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109268745 (KRAS)
   05170 Human immunodeficiency virus 1 infection
    109268745 (KRAS)
   05161 Hepatitis B
    109268745 (KRAS)
   05160 Hepatitis C
    109268745 (KRAS)
   05163 Human cytomegalovirus infection
    109268745 (KRAS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109268745 (KRAS)
   05165 Human papillomavirus infection
    109268745 (KRAS)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109268745 (KRAS)
   05022 Pathways of neurodegeneration - multiple diseases
    109268745 (KRAS)
  09165 Substance dependence
   05034 Alcoholism
    109268745 (KRAS)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109268745 (KRAS)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    109268745 (KRAS)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109268745 (KRAS)
   01522 Endocrine resistance
    109268745 (KRAS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ppad04131]
    109268745 (KRAS)
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins [BR:ppad04031]
    109268745 (KRAS)
Membrane trafficking [BR:ppad04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    109268745 (KRAS)
GTP-binding proteins [BR:ppad04031]
 Small (monomeric) G-proteins
  Ras Family
   Ras [OT]
    109268745 (KRAS)
SSDB
Motif
Pfam: Ras Roc Arf GTP_EFTU MMR_HSR1 RsgA_GTPase G-alpha ATP_bind_1 FeoB_N Septin
Other DBs
NCBI-GeneID: 109268745
NCBI-ProteinID: XP_019307790
Ensembl: ENSPPRG00000007389
UniProt: A0A9V1FRI6
Position
Unknown
AA seq 189 aa
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKINKEEKTPGC
VKIKKCIVM
NT seq 570 nt   +upstreamnt  +downstreamnt
atgactgaatataaacttgtggtagttggagctggtggcgtaggcaagagtgccttgacg
atacagctaattcagaatcactttgtggatgaatatgatcctacaatagaggattcctac
aggaaacaagtagtaattgatggagaaacctgtctcttggatattctcgacacagcaggt
caagaggagtacagtgcaatgagggaccagtacatgaggactggggagggctttctttgt
gtatttgccataaataatactaaatcatttgaagatattcaccactatagagaacaaata
aaaagagttaaagactctgaagatgtacctatggtcctagtaggaaataaatgtgatttg
ccttctagaacagtagatacgaaacaggctcaggacttagcaagaagttatggaattcct
tttattgaaacatcagcaaagacaagacagagagtggaggatgctttttatacattggtg
agagagatccgacagtacagattgaaaaaaatcaacaaagaagaaaagactcctggctgt
gtgaaaattaaaaaatgcattgtaatgtaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (83)   
   KEGG PATHWAY (83)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (4)   
DNA sequence (4)   
   RefSeq(nuc) (4)   
Protein domain (10)   
   Pfam (10)   
All databases (110)   

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