KEGG   Panthera pardus (leopard): 109273067
Entry
109273067         CDS       T06062                                 
Symbol
PTK2
Name
(RefSeq) focal adhesion kinase 1 isoform X1
  KO
K05725  focal adhesion kinase 1 [EC:2.7.10.2]
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad01522  Endocrine resistance
ppad04012  ErbB signaling pathway
ppad04062  Chemokine signaling pathway
ppad04148  Efferocytosis
ppad04151  PI3K-Akt signaling pathway
ppad04360  Axon guidance
ppad04370  VEGF signaling pathway
ppad04510  Focal adhesion
ppad04670  Leukocyte transendothelial migration
ppad04810  Regulation of actin cytoskeleton
ppad04935  Growth hormone synthesis, secretion and action
ppad05100  Bacterial invasion of epithelial cells
ppad05135  Yersinia infection
ppad05146  Amoebiasis
ppad05163  Human cytomegalovirus infection
ppad05165  Human papillomavirus infection
ppad05170  Human immunodeficiency virus 1 infection
ppad05200  Pathways in cancer
ppad05202  Transcriptional misregulation in cancer
ppad05205  Proteoglycans in cancer
ppad05208  Chemical carcinogenesis - reactive oxygen species
ppad05222  Small cell lung cancer
ppad05417  Lipid and atherosclerosis
ppad05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    109273067 (PTK2)
   04370 VEGF signaling pathway
    109273067 (PTK2)
   04151 PI3K-Akt signaling pathway
    109273067 (PTK2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    109273067 (PTK2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    109273067 (PTK2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109273067 (PTK2)
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    109273067 (PTK2)
   04062 Chemokine signaling pathway
    109273067 (PTK2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    109273067 (PTK2)
  09158 Development and regeneration
   04360 Axon guidance
    109273067 (PTK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109273067 (PTK2)
   05202 Transcriptional misregulation in cancer
    109273067 (PTK2)
   05205 Proteoglycans in cancer
    109273067 (PTK2)
   05208 Chemical carcinogenesis - reactive oxygen species
    109273067 (PTK2)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    109273067 (PTK2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    109273067 (PTK2)
   05163 Human cytomegalovirus infection
    109273067 (PTK2)
   05165 Human papillomavirus infection
    109273067 (PTK2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    109273067 (PTK2)
   05100 Bacterial invasion of epithelial cells
    109273067 (PTK2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    109273067 (PTK2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109273067 (PTK2)
   05418 Fluid shear stress and atherosclerosis
    109273067 (PTK2)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    109273067 (PTK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ppad01001]
    109273067 (PTK2)
   01009 Protein phosphatases and associated proteins [BR:ppad01009]
    109273067 (PTK2)
Enzymes [BR:ppad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     109273067 (PTK2)
Protein kinases [BR:ppad01001]
 Non-receptor tyrosine kinases
  FAK family
   109273067 (PTK2)
Protein phosphatases and associated proteins [BR:ppad01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     109273067 (PTK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Focal_AT Pkinase FERM_C_FAK1 FERM_N_2 FERM_M Kinase-like Haspin_kinase FERM_F2 GIT1_C ABC1
Other DBs
NCBI-GeneID: 109273067
NCBI-ProteinID: XP_019315277
Ensembl: ENSPPRG00000003723
Position
Unknown
AA seq 1155 aa
MLVELAGREALRPAGAVCMEKSGCGPFPVCWAKDYDRYIAPSKIMAAAYLDPNLNHTPNS
STKTHLGTGVERSPGAMERVLKVFHYFENSSEPATWASIIRHGDATDVRGIIQKIVDSHK
VKHVACYGFRLSHLRSEEVHWLHLDMGVSNVREKYELAHPPEEWKYELRIRYLPKGFLNQ
FTEDKPTLNFFYQQVKSDYMSEIADRVDQDIALKLGCLEIRRSYWEMRGNALEKKSNYEV
LEKDVGLKRFFPRSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKE
CFKCALGSSWIISVELAIGPEEGISYLTDKGCSPTHLADFNQVQTIQYSNSEDKDRKGTL
QLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFIIRPQKEGERALPSIPKL
ANSEKQGVRTHAVSVSGIYPDITHSAARALTWASRSVPSLGALATSPSPLTLLSPCPTSL
LLETDDYAEIIDEEDTYTMPSKSYGIDEARDYEIQRERIELGRCIGEGQFGDVHQGVYMS
PENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLVGVITENPVWIIMELCT
LGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLG
DFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPF
QGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEE
KVQQEERMRMESRRQVTVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQ
VSGYPGSHGVTATAGSIYPGQASLLDQTDSWNHRPQEISMWQPNVEDSAALDLRGIGQVL
PTQLVEERLIRQQQEMEEDQRWLEKEERFLVILKPDVRLSRGSIDREDGSLQGPTGNQHI
YQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPGDSYNEGVKPWRLQPQEISPPPTANL
DRSNDRVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETLPVLPA
STHREIEMAQKLLNSDLGELINKMKLAQRCAMTSLQQDHKKQMLTAAHALAVDAKNLLDV
IDQARLRALGHARPR
NT seq 3468 nt   +upstreamnt  +downstreamnt
atgttggtggaactggcgggccgagaggccctgagaccagcaggtgccgtctgtatggag
aagagcggctgtggtccatttccagtgtgttgggctaaagattatgacagatacatagca
ccaagcaaaataatggcagctgcttaccttgacccaaacttgaatcacaccccgaattcg
agtaccaagacccatctgggtaccggagtggaacgttcccccggggcaatggagcgagtg
ttgaaggtctttcattattttgagaacagcagtgagccagccacttgggccagtattatc
aggcacggagatgctactgatgtcaggggcatcattcagaagatagtggacagtcacaaa
gtaaagcacgtggcctgctatggatttcgcctcagtcacctgcggtcagaggaggttcac
tggctccatttggatatgggtgtctccaatgtgagggagaagtatgaacttgcacaccca
ccagaggagtggaaatatgaattgagaattcgttatttgccaaaaggatttctaaaccag
tttactgaagacaagccaactctgaatttcttctatcaacaggtgaaaagtgactacatg
tcggagatagctgaccgggtggaccaggacatcgctttgaagctgggctgcctagaaata
cggcgctcgtattgggagatgcgaggcaacgcgctagagaagaagtccaactatgaggtg
ttagaaaaagatgttggtttgaagcgattttttcctaggagtttactggattctgtcaag
gccaaaacactaagaaaactgatccagcagacatttagacagttcgccaacctgaacaga
gaagagagcattctgaaattctttgagatcctctccccagtgtaccgatttgataaagag
tgcttcaagtgtgccctcggttcaagctggattatttcagtggaactggcgatcggccca
gaagaaggaatcagttacctcacggacaagggctgcagccccacacatctggccgacttc
aatcaagtgcagaccattcagtattccaacagcgaagacaaggacaggaaaggaacgctg
cagctgaaaatcgcgggcgcccccgagcctctgacagtgacagcaccgtccctgaccatc
gccgagaatatggctgacctgatagatgggtactgccggctggtgaacggagccacgcag
tcctttatcatcaggccccagaaagaaggtgaacgggctttgccatcaataccaaagctg
gccaacagcgagaagcaaggcgtgcggacacacgcggtctccgtgtcaggcatctaccct
gacatcactcacagcgcagccagagccctgacgtgggcttctaggtctgtgccatcactg
ggagcactggccacctctccctcacccctcactcttttgtcaccctgcccaacctcattg
ctcctcgaaaccgacgactatgctgagattatagacgaagaagatacctacaccatgccc
tcaaaaagctatggaatagacgaagccagggactacgagattcaaagagaaaggatcgag
cttggacggtgcatcggggaaggccagtttggggacgtccaccaaggcgtctacatgagt
ccagagaatccggctttggcggtcgcaattaaaacatgtaaaaactgtacttcggacagc
gtgcgagagaaattccttcaagaagccttaacgatgcgccagtttgaccacccccacatc
gtgaagctggtcggtgtcatcacggagaaccccgtctggataatcatggagttgtgcacg
cttggagagctgaggtcgtttctgcaagtgaggaagtacagtttggatctcgcgtctttg
atcctgtatgcctatcagcttagtacagctctggcgtatctggagagcaaaagattcgtg
cacagggacattgctgctcggaatgttctggtgtcctcaaacgattgcgtaaaattagga
gactttggattatcccggtatatggaagacagtacttactacaaagcttccaaaggaaag
ttgcctattaaatggatggctccagagtccatcaactttcgacgttttacctcagccagt
gacgtgtggatgtttggtgtgtgtatgtgggagatactgatgcatggtgtgaagccgttt
caaggagtgaagaacaatgatgtgatcggtcgaatcgagaacggggagagattaccaatg
cctccaaattgccctcccaccctctacagccttatgacgaaatgctgggcctatgacccc
agcaggcggccccggttcactgagctcaaagctcagctcagcaccatcctggaggaggag
aaggttcagcaagaagaacgaatgaggatggaatcccgaagacaggtcacagtgtcctgg
gactccggagggtccgacgaagcgccacccaagcccagcagacctggttaccccagtccg
cggtccagcgaaggattttatcccagtccccagcacatggtacagaccaatcattaccag
gtgtctggctatcctggttcacatggggtcacagccacggctggcagcatctacccgggt
caggcatctcttttggaccagacggactcatggaatcacagaccacaggagatatcgatg
tggcagcccaacgtggaggactctgcggccctggacctgcgcgggatcgggcaggtgctg
cccacccagctggtggaagagcggctgatccggcagcagcaggaaatggaggaggaccag
cgctggctcgagaaagaggagagattcctggtcatcctgaaacccgacgtgcggctctct
cgaggcagcatcgacagggaggacgggagtcttcagggcccgacgggaaaccaacacatc
tatcagcctgtgggtaaaccagatcccgcagctccgccaaagaaaccgccgcggcctgga
gcccccggtcacctgggcagcctcgccagcctcagcagccccggggacagttacaacgag
ggcgtcaagccatggaggcttcagccccaggaaatcagccccccgcccactgccaacctg
gaccggtccaacgacagggtgtacgagaatgtgacgggcctggtgaaggctgtcatcgaa
atgtccagcaagatccagccagcccccccggaggagtacgttcccatggtgaaggaagtc
ggcctggccctgcggacattactggccaccgtggacgagacccttccagtcctgccagcc
agcactcaccgagagatcgagatggcccagaagctgttgaactccgacctgggcgagctc
atcaacaagatgaagctggcccagcggtgcgccatgaccagcctacagcaggaccacaag
aagcagatgctgaccgccgcccacgccctggccgtggacgccaagaacttactcgacgtc
atcgaccaggccagactgagggcactcggacacgcgaggccgcgctga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (24)   
   KEGG PATHWAY (24)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (18)   
   RefSeq(pep) (18)   
DNA sequence (18)   
   RefSeq(nuc) (18)   
Protein domain (11)   
   Pfam (11)   
All databases (81)   

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